Ces1d (carboxylesterase 1D) - Rat Genome Database

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Gene: Ces1d (carboxylesterase 1D) Rattus norvegicus
Analyze
Symbol: Ces1d
Name: carboxylesterase 1D
RGD ID: 70896
Description: Enables retinyl-palmitate esterase activity. Predicted to be involved in several processes, including cellular response to cholesterol; cholesterol homeostasis; and regulation of steroid metabolic process. Predicted to act upstream of or within several processes, including cellular lipid catabolic process; circadian temperature homeostasis; and cold-induced thermogenesis. Located in intracellular membrane-bounded organelle. Biomarker of liver cancer. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1); PARTICIPATES IN capecitabine pharmacodynamics pathway; capecitabine pharmacokinetics pathway; heroin pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carboxyesterase ES-10; carboxylesterase 3; Ces3; ES-HVEL; FAEE synthase; fatty acid ethyl ester synthase; liver carboxylesterase 10; pI 6.1 esterase
RGD Orthologs
Human
Mouse
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,046,494 - 30,085,039 (+)NCBIGRCr8
mRatBN7.21913,873,490 - 13,912,035 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,796,623 - 13,912,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1915,575,724 - 15,607,760 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01920,770,483 - 20,802,524 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01923,715,935 - 23,748,063 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01915,195,514 - 15,239,827 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1915,033,108 - 15,239,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01926,294,247 - 26,337,106 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41914,928,539 - 14,967,082 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11914,933,410 - 14,971,894 (+)NCBI
Celera1913,805,706 - 13,843,668 (+)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+)-trans-(S)-allethrin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(2-nitrophenyl)acetic acid  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(4-nitrophenyl)acetic acid  (ISO)
1,2-dibromoethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-benzofuran  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2-Bis(bromomethyl)propane-1,3-diol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(chloromethyl)pyridine  (ISO)
2-arachidonoylglycerol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-naphthol  (ISO)
2-nitrophenol  (ISO)
2-tert-butylhydroquinone  (ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylumbelliferyl acetate  (ISO)
4-nitrophenol  (ISO)
4-nitrophenyl acetate  (ISO)
5'-Deoxy-5-fluorocytidine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-Acetylmorphine  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acridines  (ISO)
acrylamide  (EXP)
Actein  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ampicillin  (ISO)
aniracetam  (ISO)
apigenin  (EXP)
arachidonic acid  (EXP,ISO)
aripiprazole  (ISO)
asbestos  (ISO)
atropine  (ISO)
avobenzone  (ISO)
azinphos-methyl  (ISO)
Bavachinin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzylpenicillin  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (ISO)
bioresmethrin  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bis-4-nitrophenyl phosphate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
cantharidin  (ISO)
capecitabine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium trinitrate  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
Cocaethylene  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
corylin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
DDT  (EXP)
Delapril hydrochloride  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextropropoxyphene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP,ISO)
Dihydrocorynantheine  (ISO)
Dihydrokavain  (ISO)
dimethocaine  (ISO)
diosgenin  (EXP)
dioxygen  (ISO)
diuron  (EXP)
ecgonine benzoate  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
everolimus  (ISO)
felbamate  (ISO)
fenofibrate  (EXP)
fenvalerate  (ISO)
flucloxacillin  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
galaxolide  (ISO)
gallocatechin  (EXP)
glafenine  (EXP)
heroin  (ISO)
Homatropine  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
imidapril  (ISO)
inulin  (ISO)
irinotecan  (ISO)
iron trichloride  (EXP,ISO)
isobavachalcone  (ISO)
kojic acid  (EXP)
L-methionine  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
luteolin  (EXP)
Magnolol  (ISO)
malathion  (ISO)
methylphenidate  (ISO)
Methysticin  (ISO)
Mitragynine  (ISO)
monoethylglycinexylidide  (EXP)
N-(1-naphthyl)ethylenediamine  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-Methylolacrylamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
naloxone  (ISO)
naphthalene-1,5-diamine  (ISO)
neobavaisoflavone  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
Octicizer  (ISO)
okadaic acid  (ISO)
oltipraz  (ISO)
oseltamivir  (ISO)
oxazepam  (ISO)
p-nitrophenyl butyrate  (ISO)
palmitoyl-CoA  (EXP)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (EXP)
paricalcitol  (ISO)
pentachloronitrobenzene  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP,ISO)
perphenazine  (ISO)
pethidine  (ISO)
phenobarbital  (ISO)
phenoxymethylpenicillin  (ISO)
phenylmethanesulfonyl fluoride  (ISO)
phosphatidylcholine  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
Propiverine  (EXP)
prostaglandin F2alpha  (ISO)
prostaglandin J2  (ISO)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
ramipril  (ISO)
remdesivir  (ISO)
rifampicin  (ISO)
ritalinic acid  (ISO)
rivastigmine  (ISO)
rotenone  (ISO)
sacubitril  (ISO)
sarin  (ISO)
SB 203580  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium cholate  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (ISO)
sulforaphane  (ISO)
tacrine  (ISO)
tanespimycin  (ISO)
Temocapril hydrochloride  (ISO)
Temocaprilat  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thioridazine  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP)
troglitazone  (EXP)
Tropacocaine  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
Yangonin  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
2. Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma. Capece D, etal., J Clin Invest. 2021 Jun 1;131(11). pii: 137845. doi: 10.1172/JCI137845.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Molecular cloning and expression of rat hepatic neutral cholesteryl ester hydrolase. Ghosh S, etal., Biochim Biophys Acta 1995 Dec 7;1259(3):305-12.
5. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
6. Identification of a prognostic 5-Gene expression signature for gastric cancer. Hou JY, etal., J Cancer Res Clin Oncol. 2017 Apr;143(4):619-629. doi: 10.1007/s00432-016-2324-z. Epub 2016 Dec 29.
7. Carboxylesterase 1 polymorphisms are associated with clinical outcomes in gastroenteric cancer patients treated with capecitabine. Liu D, etal., Cancer Chemother Pharmacol. 2021 May;87(5):681-687. doi: 10.1007/s00280-021-04247-9. Epub 2021 Feb 14.
8. The carboxylesterase family exhibits C-terminal sequence diversity reflecting the presence or absence of endoplasmic-reticulum-retention sequences. Medda S and Proia RL, Eur J Biochem 1992 Jun 15;206(3):801-6.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Human plasma carboxylesterase 1, a novel serologic biomarker candidate for hepatocellular carcinoma. Na K, etal., Proteomics. 2009 Aug;9(16):3989-99. doi: 10.1002/pmic.200900105.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. Proteomic profiling of N-linked glycoproteins identifies ConA-binding procathepsin D as a novel serum biomarker for hepatocellular carcinoma. Qi YJ, etal., Proteomics. 2014 Feb;14(2-3):186-95. doi: 10.1002/pmic.201300226.
15. Hepatic carboxylesterase 3 (Ces3/Tgh) is downregulated in the early stages of liver cancer development in the rat. Quiroga AD, etal., Biochim Biophys Acta. 2016 Nov;1862(11):2043-2053. doi: 10.1016/j.bbadis.2016.08.006. Epub 2016 Aug 12.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Nucleotide sequence of cDNA coding for rat liver pI 6.1 esterase (ES-10), a carboxylesterase located in the lumen of the endoplasmic reticulum. Robbi M, etal., Biochem J 1990 Jul 15;269(2):451-8.
20. Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate. Sanghani SP, etal., Eur J Biochem 2002 Sep;269(18):4387-98.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Mutation of residues 423 (Met/Ile), 444 (Thr/Met), and 506 (Asn/Ser) confer cholesteryl esterase activity on rat lung carboxylesterase. Ser-506 is required for activation by cAMP-dependent protein kinase. Wallace TJ, etal., J Biol Chem 2001 Aug 31;276(35):33165-74.
Additional References at PubMed
PMID:11015575   PMID:11470237   PMID:12947022   PMID:15220344   PMID:15489334   PMID:16024911   PMID:16804080   PMID:16971496   PMID:18599737   PMID:18762277   PMID:20197051   PMID:21492153  


Genomics

Comparative Map Data
Ces1d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,046,494 - 30,085,039 (+)NCBIGRCr8
mRatBN7.21913,873,490 - 13,912,035 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,796,623 - 13,912,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1915,575,724 - 15,607,760 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01920,770,483 - 20,802,524 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01923,715,935 - 23,748,063 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01915,195,514 - 15,239,827 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1915,033,108 - 15,239,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01926,294,247 - 26,337,106 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41914,928,539 - 14,967,082 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11914,933,410 - 14,971,894 (+)NCBI
Celera1913,805,706 - 13,843,668 (+)NCBICelera
Cytogenetic Map19p11NCBI
CES1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381655,802,851 - 55,833,096 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1655,802,851 - 55,833,337 (-)EnsemblGRCh38hg38GRCh38
GRCh371655,836,763 - 55,867,008 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,394,264 - 54,424,576 (-)NCBINCBI36Build 36hg18NCBI36
Build 341654,394,266 - 54,424,494NCBI
Celera1640,340,608 - 40,363,542 (-)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1641,715,157 - 41,738,637 (-)NCBIHuRef
CHM1_11657,243,691 - 57,273,987 (-)NCBICHM1_1
T2T-CHM13v2.01661,597,797 - 61,628,094 (-)NCBIT2T-CHM13v2.0
Ces1d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,892,700 - 93,924,432 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl893,892,696 - 93,924,466 (-)EnsemblGRCm39 Ensembl
GRCm38893,166,072 - 93,197,804 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl893,166,068 - 93,197,838 (-)EnsemblGRCm38mm10GRCm38
MGSCv37895,689,971 - 95,721,703 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36896,055,199 - 96,086,907 (-)NCBIMGSCv36mm8
Celera897,494,847 - 97,526,574 (-)NCBICelera
Cytogenetic Map8C5NCBI
cM Map845.05NCBI
CES1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1260,276,723 - 60,305,970 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl260,236,150 - 60,321,178 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,910,019 - 56,939,263 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0260,821,659 - 60,850,937 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,780,757 - 60,850,933 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,648,966 - 57,678,189 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,666,817 - 58,696,060 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,551,840 - 59,581,084 (+)NCBIUU_Cfam_GSD_1.0
CES1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1629,884,249 - 29,913,330 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2627,276,898 - 27,308,831 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233018
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1541,710,500 - 41,745,483 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604734,632,451 - 34,798,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ces1d
932 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:23
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000021812
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat

Markers in Region
RH133410  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21922,592,007 - 22,592,189 (+)MAPPERmRatBN7.2
mRatBN7.21913,911,691 - 13,911,873 (+)MAPPERmRatBN7.2
Rnor_6.01915,239,484 - 15,239,665NCBIRnor6.0
Rnor_5.01926,336,763 - 26,336,944UniSTSRnor5.0
RGSC_v3.41914,966,739 - 14,966,920UniSTSRGSC3.4
Celera1913,843,325 - 13,843,506UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map19p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 12 28 15 5 15 1 1 21 14 11 1
Low 2 3 9 6 12 6 7 10 10 8 9 7
Below cutoff 8 12 12 2 12 12 4 7

Sequence


RefSeq Acc Id: ENSRNOT00000021812   ⟹   ENSRNOP00000021812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1922,560,770 - 22,592,351 (+)Ensembl
Rnor_6.0 Ensembl1915,033,108 - 15,239,821 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078874   ⟹   ENSRNOP00000072835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1915,195,565 - 15,239,638 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090865   ⟹   ENSRNOP00000070536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1915,195,565 - 15,239,638 (+)Ensembl
RefSeq Acc Id: NM_133295   ⟹   NP_579829
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81930,046,494 - 30,085,039 (+)NCBI
mRatBN7.21913,873,490 - 13,912,035 (+)NCBI
Rnor_6.01915,195,514 - 15,239,827 (+)NCBI
Rnor_5.01926,294,247 - 26,337,106 (+)NCBI
RGSC_v3.41914,928,539 - 14,967,082 (+)RGD
Celera1913,805,706 - 13,843,668 (+)RGD
Sequence:
RefSeq Acc Id: NP_579829   ⟸   NM_133295
- Peptide Label: precursor
- UniProtKB: Q9R135 (UniProtKB/Swiss-Prot),   Q9QUX7 (UniProtKB/Swiss-Prot),   Q91YG2 (UniProtKB/Swiss-Prot),   Q6P785 (UniProtKB/Swiss-Prot),   Q64574 (UniProtKB/Swiss-Prot),   P16303 (UniProtKB/Swiss-Prot),   A0A0G2JY66 (UniProtKB/TrEMBL),   A6KD48 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021812   ⟸   ENSRNOT00000021812
RefSeq Acc Id: ENSRNOP00000070536   ⟸   ENSRNOT00000090865
RefSeq Acc Id: ENSRNOP00000072835   ⟸   ENSRNOT00000078874
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16303-F1-model_v2 AlphaFold P16303 1-565 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700979
Promoter ID:EPDNEW_R11489
Type:initiation region
Name:Ces1d_1
Description:carboxylesterase 1D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01915,195,503 - 15,195,563EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70896 AgrOrtholog
BioCyc Gene G2FUF-6406 BioCyc
Ensembl Genes ENSRNOG00000015438 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000015519 Ensembl
Ensembl Transcript ENSRNOT00000078874.2 UniProtKB/TrEMBL
  ENSRNOT00000083500.2 UniProtKB/TrEMBL
  ENSRNOT00000085762.2 UniProtKB/TrEMBL
  ENSRNOT00000090865 ENTREZGENE
  ENSRNOT00000090865.2 UniProtKB/TrEMBL
  ENSRNOT00000101266.1 UniProtKB/TrEMBL
  ENSRNOT00000110686.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623732 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:113902 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72259 IMAGE-MGC_LOAD
NCBI Gene 113902 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYLESTERASE 1E-RELATED UniProtKB/TrEMBL
  CARBOXYLESTERASE 1F UniProtKB/TrEMBL
  LIVER CARBOXYLESTERASE 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ces1d PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015438 RatGTEx
  ENSRNOG00000015519 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JX75_RAT UniProtKB/TrEMBL
  A0A0G2JY66 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K3Z4_RAT UniProtKB/TrEMBL
  A0A0G2K9Y7_RAT UniProtKB/TrEMBL
  A0A8I5ZUX9_RAT UniProtKB/TrEMBL
  A0A8I6AML8_RAT UniProtKB/TrEMBL
  A6KD48 ENTREZGENE, UniProtKB/TrEMBL
  CES1D_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64574 ENTREZGENE
  Q6P785 ENTREZGENE
  Q91YG2 ENTREZGENE
  Q9QUX7 ENTREZGENE
  Q9R135 ENTREZGENE
UniProt Secondary Q64574 UniProtKB/Swiss-Prot
  Q6P785 UniProtKB/Swiss-Prot
  Q91YG2 UniProtKB/Swiss-Prot
  Q9QUX7 UniProtKB/Swiss-Prot
  Q9R135 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-18 Ces1d  carboxylesterase 1D  Ces3  carboxylesterase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Ces3  carboxylesterase 3      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in liver 632435
gene_protein predicted protein masses 62 kDa 632435
gene_protein mature protein consists of 547 aa residues 70683