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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | affects expression | ISO | RGD:68506 | 6480464 | 1, 2-Dimethylhydrazine affects the expression of PDCD6IP mRNA | CTD | PMID:22206623 | 1,4-dithiothreitol | increases expression | ISO | RGD:68505 | 6480464 | Dithiothreitol results in increased expression of PDCD6IP protein | CTD | PMID:21692457 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | decreases expression | ISO | RGD:68506 | 6480464 | 1-Methyl-4-phenyl-1 more ... | CTD | PMID:15329391 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of PDCD6IP mRNA | CTD | PMID:17557909 | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | decreases expression | ISO | RGD:68505 | 6480464 | Metribolone results in decreased expression of PDCD6IP protein | CTD | PMID:17152098 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:68506 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PDCD6IP mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PDCD6IP mRNA | CTD | PMID:33387578 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2, 4-dinitrotoluene affects the expression of PDCD6IP mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2, 6-dinitrotoluene affects the expression of PDCD6IP mRNA | CTD | PMID:21346803 | 2-hydroxypropanoic acid | decreases expression | ISO | RGD:68505 | 6480464 | Lactic Acid results in decreased expression of PDCD6IP mRNA | CTD | PMID:30851411 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:68506 | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of PDCD6IP mRNA | CTD | PMID:20188158 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:68505 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PDCD6IP mRNA | CTD | PMID:28628672 | 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid | multiple interactions | ISO | RGD:68505 | 6480464 | 4 more ... | CTD | PMID:29421517 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | RGD:68505 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PDCD6IP mRNA | CTD | PMID:28628672 | 5-fluorouracil | decreases expression | ISO | RGD:68505 | 6480464 | Fluorouracil results in decreased expression of PDCD6IP mRNA | CTD | PMID:17039268 | acrolein | multiple interactions | ISO | RGD:68505 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of PDCD6IP mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of PDCD6IP mRNA | CTD | PMID:32699268 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of PDCD6IP mRNA | CTD | PMID:28959563 | aflatoxin B1 | decreases methylation | ISO | RGD:68505 | 6480464 | Aflatoxin B1 results in decreased methylation of PDCD6IP gene | CTD | PMID:27153756 | all-trans-retinoic acid | increases expression | ISO | RGD:68505 | 6480464 | Tretinoin results in increased expression of PDCD6IP mRNA | CTD | PMID:33167477 | alpha-pinene | multiple interactions | ISO | RGD:68505 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of PDCD6IP mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of PDCD6IP mRNA | CTD | PMID:32699268 | antimycin A | decreases expression | ISO | RGD:68505 | 6480464 | Antimycin A results in decreased expression of PDCD6IP mRNA | CTD | PMID:33512557 | aristolochic acid | decreases expression | ISO | RGD:68505 | 6480464 | aristolochic acid I results in decreased expression of PDCD6IP mRNA | CTD | PMID:33212167 | atrazine | decreases expression | ISO | RGD:68505 | 6480464 | Atrazine results in decreased expression of PDCD6IP mRNA | CTD | PMID:22378314 | azoxystrobin | decreases expression | ISO | RGD:68505 | 6480464 | azoxystrobin results in decreased expression of PDCD6IP mRNA | CTD | PMID:33512557 | beauvericin | increases expression | ISO | RGD:68505 | 6480464 | beauvericin results in increased expression of PDCD6IP mRNA | CTD | PMID:29203277 | benzo[a]pyrene | decreases expression | ISO | RGD:68505 | 6480464 | Benzo(a)pyrene results in decreased expression of PDCD6IP mRNA | CTD | PMID:20064835 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of PDCD6IP protein | CTD | PMID:31368503 | benzo[a]pyrene | increases methylation | ISO | RGD:68505 | 6480464 | Benzo(a)pyrene results in increased methylation of PDCD6IP promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | RGD:68506 | 6480464 | Benzo(a)pyrene results in increased expression of PDCD6IP mRNA | CTD | PMID:22228805 | benzo[a]pyrene | multiple interactions | ISO | RGD:68506 | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PDCD6IP mRNA] | CTD | PMID:22228805 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PDCD6IP mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PDCD6IP mRNA | CTD | PMID:30816183 | Brodifacoum | increases expression | EXP | | 6480464 | bromfenacoum results in increased expression of PDCD6IP protein | CTD | PMID:28903499 | calcitriol | increases expression | ISO | RGD:68505 | 6480464 | Calcitriol results in increased expression of PDCD6IP mRNA | CTD | PMID:16002434 | carbon nanotube | increases expression | ISO | RGD:68506 | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | copper(II) sulfate | increases expression | ISO | RGD:68505 | 6480464 | Copper Sulfate results in increased expression of PDCD6IP mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | ISO | RGD:68505 | 6480464 | [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PDCD6IP mRNA | CTD | PMID:19167446 | coumestrol | decreases expression | ISO | RGD:68505 | 6480464 | Coumestrol results in decreased expression of PDCD6IP mRNA | CTD | PMID:19167446 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of PDCD6IP mRNA | CTD | PMID:27523638 | dexamethasone | multiple interactions | ISO | RGD:68505 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PDCD6IP mRNA | CTD | PMID:28628672 | dibenz[a,h]anthracene | increases expression | EXP | | 6480464 | 1 more ... | CTD | PMID:31368503 | dibutyl phthalate | increases expression | ISO | RGD:68506 | 6480464 | Dibutyl Phthalate results in increased expression of PDCD6IP mRNA | CTD | PMID:21266533 | dioxygen | increases expression | ISO | RGD:68506 | 6480464 | Oxygen deficiency results in increased expression of PDCD6IP mRNA | CTD | PMID:24205000 | Enterolactone | multiple interactions | ISO | RGD:68505 | 6480464 | [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PDCD6IP mRNA | CTD | PMID:19167446 | enzyme inhibitor | multiple interactions | ISO | RGD:68505 | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PDCD6IP protein | CTD | PMID:23301498 | ethanol | affects splicing | ISO | RGD:68506 | 6480464 | Ethanol affects the splicing of PDCD6IP mRNA | CTD | PMID:30319688 | flavonoids | decreases expression | EXP | | 6480464 | Flavonoids results in decreased expression of PDCD6IP mRNA | CTD | PMID:18035473 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of PDCD6IP mRNA | CTD | PMID:24136188 | folic acid | decreases expression | ISO | RGD:68506 | 6480464 | Folic Acid results in decreased expression of PDCD6IP mRNA | CTD | PMID:25629700 | genistein | increases expression | ISO | RGD:68505 | 6480464 | Genistein results in increased expression of PDCD6IP mRNA | CTD | PMID:18847459 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of PDCD6IP mRNA, Gentamicins results in decreased expression of PDCD6IP protein | CTD | PMID:22061828 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PDCD6IP mRNA | CTD | PMID:22061828, PMID:33387578 | gentamycin | increases secretion | EXP | | 6480464 | Gentamicins results in increased secretion of PDCD6IP protein | CTD | PMID:25339697 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of PDCD6IP mRNA | CTD | PMID:24136188 | indometacin | multiple interactions | ISO | RGD:68505 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PDCD6IP mRNA | CTD | PMID:28628672 | ivermectin | decreases expression | ISO | RGD:68505 | 6480464 | Ivermectin results in decreased expression of PDCD6IP protein | CTD | PMID:32959892 | L-1,4-dithiothreitol | increases expression | ISO | RGD:68505 | 6480464 | Dithiothreitol results in increased expression of PDCD6IP protein | CTD | PMID:21692457 | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of PDCD6IP mRNA | CTD | PMID:30467583 | methylmercury chloride | decreases expression | ISO | RGD:68505 | 6480464 | methylmercuric chloride results in decreased expression of PDCD6IP mRNA | CTD | PMID:28001369 | morusin | decreases expression | ISO | RGD:68505 | 6480464 | morusin results in decreased expression of PDCD6IP protein | CTD | PMID:29421517 | morusin | multiple interactions | ISO | RGD:68505 | 6480464 | 4 more ... | CTD | PMID:29421517 | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | increases expression | ISO | RGD:68505 | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PDCD6IP protein | CTD | PMID:21692457 | nitric oxide | decreases expression | ISO | RGD:68506 | 6480464 | Nitric Oxide deficiency results in decreased expression of PDCD6IP mRNA | CTD | PMID:15878706 | oxybenzone | decreases expression | EXP | | 6480464 | oxybenzone results in decreased expression of PDCD6IP mRNA | CTD | PMID:30316929 | ozone | multiple interactions | ISO | RGD:68505 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of PDCD6IP mRNA more ... | CTD | PMID:32699268 | paracetamol | decreases expression | ISO | RGD:68505 | 6480464 | Acetaminophen results in decreased expression of PDCD6IP mRNA | CTD | PMID:21420995 | phenobarbital | decreases expression | ISO | RGD:68506 | 6480464 | Phenobarbital results in decreased expression of PDCD6IP mRNA | CTD | PMID:23091169 | picoxystrobin | decreases expression | ISO | RGD:68505 | 6480464 | picoxystrobin results in decreased expression of PDCD6IP mRNA | CTD | PMID:33512557 | poly(I:C) | multiple interactions | EXP | | 6480464 | [Poly I-C co-treated with HU 211] results in decreased expression of PDCD6IP mRNA | CTD | PMID:26923065 | pyrene | increases expression | EXP | | 6480464 | pyrene results in increased expression of PDCD6IP protein | CTD | PMID:31368503 | rac-lactic acid | decreases expression | ISO | RGD:68505 | 6480464 | Lactic Acid results in decreased expression of PDCD6IP mRNA | CTD | PMID:30851411 | rotenone | increases expression | ISO | RGD:68505 | 6480464 | Rotenone results in increased expression of PDCD6IP protein | CTD | PMID:25682864 | rotenone | decreases expression | ISO | RGD:68505 | 6480464 | Rotenone results in decreased expression of PDCD6IP mRNA | CTD | PMID:33512557 | rotenone | increases oxidation | EXP | | 6480464 | Rotenone results in increased oxidation of PDCD6IP protein | CTD | PMID:30951809 | sodium dichromate | decreases expression | EXP | | 6480464 | sodium bichromate results in decreased expression of PDCD6IP mRNA | CTD | PMID:25993096 | succimer | multiple interactions | ISO | RGD:68506 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PDCD6IP mRNA | CTD | PMID:21641980 | thapsigargin | increases expression | ISO | RGD:68505 | 6480464 | Thapsigargin results in increased expression of PDCD6IP mRNA, Thapsigargin results in increased expression of PDCD6IP protein | CTD | PMID:21692457 | titanium dioxide | increases expression | ISO | RGD:68506 | 6480464 | titanium dioxide results in increased expression of PDCD6IP mRNA | CTD | PMID:29264374 | trichloroethene | decreases expression | ISO | RGD:68506 | 6480464 | Trichloroethylene results in decreased expression of PDCD6IP mRNA | CTD | PMID:19448997 | troglitazone | decreases expression | ISO | RGD:68506 | 6480464 | troglitazone results in decreased expression of PDCD6IP mRNA | CTD | PMID:28973697 | tungsten | decreases expression | ISO | RGD:68506 | 6480464 | Tungsten results in decreased expression of PDCD6IP mRNA | CTD | PMID:30912803 | uranium atom | affects expression | ISO | RGD:68505 | 6480464 | Uranium affects the expression of PDCD6IP mRNA | CTD | PMID:15672453 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of PDCD6IP mRNA | CTD | PMID:19015723 | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of PDCD6IP mRNA | CTD | PMID:23034163 | zearalenone | multiple interactions | ISO | RGD:68506 | 6480464 | [Zearalenone co-treated with CGA protein] results in increased expression of PDCD6IP protein | CTD | PMID:25058043 | |