Symbol:
Appl1
Name:
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
RGD ID:
1309388
Description:
Predicted to enable several functions, including beta-tubulin binding activity; phospholipid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of biosynthetic process; and regulation of endocytosis. Is active in postsynapse and presynapse. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 14. Orthologous to human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1); PARTICIPATES IN colorectal cancer pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; DCC-interacting protein 13-alpha; LOC290537; RGD1309388; similar to DIP13 alpha
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Appl1 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Appl1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Appl1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Appl1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Appl1 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
hesx1 (HESX homeobox 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
appl1
Alliance
DIOPT (Ensembl Compara|OMA|OrthoFinder|PANTHER)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 16 2,125,234 - 2,173,457 (-) NCBI GRCr8 mRatBN7.2 16 2,118,503 - 2,166,741 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 16 2,121,255 - 2,166,692 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 16 2,125,142 - 2,173,305 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 16 3,270,829 - 3,318,993 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 16 2,131,417 - 2,179,844 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 16 2,560,103 - 2,602,035 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 16 2,563,520 - 2,602,103 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 16 2,534,851 - 2,581,754 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 16 2,180,613 - 2,227,905 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 16 2,179,191 - 2,228,173 (-) NCBI Celera 16 2,089,133 - 2,134,528 (-) NCBI Celera Cytogenetic Map 16 p16 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Appl1 Rat (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of APPL1 mRNA] CTD PMID:31150632 Appl1 Rat (1->4)-beta-D-glucan multiple interactions ISO Appl1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of APPL1 mRNA CTD PMID:36331819 Appl1 Rat 1,2-dimethylhydrazine decreases expression ISO Appl1 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of APPL1 mRNA CTD PMID:22206623 Appl1 Rat 1,2-dimethylhydrazine multiple interactions ISO Appl1 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of APPL1 mRNA CTD PMID:22206623 Appl1 Rat 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of APPL1 mRNA CTD PMID:25380136 Appl1 Rat 17alpha-ethynylestradiol increases expression ISO Appl1 (Mus musculus) 6480464 Ethinyl Estradiol results in increased expression of APPL1 mRNA CTD PMID:17555576 Appl1 Rat 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of APPL1 mRNA CTD PMID:29097150 Appl1 Rat 17beta-estradiol increases expression ISO Appl1 (Mus musculus) 6480464 Estradiol results in increased expression of APPL1 mRNA CTD PMID:39298647 Appl1 Rat 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:27291303 Appl1 Rat 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO APPL1 (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 Appl1 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Appl1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of APPL1 mRNA CTD PMID:19770486 Appl1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Appl1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of APPL1 mRNA CTD PMID:21570461 Appl1 Rat 2,4,6-tribromophenol decreases expression ISO APPL1 (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 Appl1 Rat 2-butoxyethanol decreases expression ISO Appl1 (Mus musculus) 6480464 n-butoxyethanol results in decreased expression of APPL1 mRNA CTD PMID:19812364 Appl1 Rat 3,3',5,5'-tetrabromobisphenol A decreases expression ISO APPL1 (Homo sapiens) 6480464 tetrabromobisphenol A results in decreased expression of APPL1 protein CTD PMID:31675489 Appl1 Rat 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO APPL1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of APPL1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of APPL1 mRNA CTD PMID:28628672 Appl1 Rat 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4 and 4'-diaminodiphenylmethane results in increased expression of APPL1 mRNA CTD PMID:25380136 Appl1 Rat 4,4'-sulfonyldiphenol multiple interactions ISO APPL1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of APPL1 mRNA CTD PMID:28628672 Appl1 Rat 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of APPL1 mRNA CTD PMID:36041667 Appl1 Rat 4,4'-sulfonyldiphenol increases expression ISO Appl1 (Mus musculus) 6480464 bisphenol S results in increased expression of APPL1 mRNA CTD PMID:39298647 Appl1 Rat aflatoxin B1 increases expression ISO Appl1 (Mus musculus) 6480464 Aflatoxin B1 results in increased expression of APPL1 mRNA CTD PMID:19770486 Appl1 Rat aristolochic acid A decreases expression ISO APPL1 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of APPL1 mRNA CTD PMID:33212167 Appl1 Rat arsane affects methylation ISO APPL1 (Homo sapiens) 6480464 Arsenic affects the methylation of APPL1 gene CTD PMID:25304211 Appl1 Rat arsenic atom affects methylation ISO APPL1 (Homo sapiens) 6480464 Arsenic affects the methylation of APPL1 gene CTD PMID:25304211 Appl1 Rat atrazine increases expression ISO APPL1 (Homo sapiens) 6480464 Atrazine results in increased expression of APPL1 mRNA CTD PMID:22378314 Appl1 Rat bafilomycin A1 multiple interactions ISO Appl1 (Mus musculus) 6480464 bafilomycin A1 promotes the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein] and bafilomycin A1 promotes the reaction [Poly I-C results in increased degradation of APPL1 protein] CTD PMID:25780039 Appl1 Rat benzo[a]pyrene increases expression ISO APPL1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of APPL1 protein CTD PMID:33278487 Appl1 Rat beta-lapachone increases expression ISO APPL1 (Homo sapiens) 6480464 beta-lapachone results in increased expression of APPL1 mRNA CTD PMID:38218311 Appl1 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of APPL1 mRNA CTD PMID:29097150 Appl1 Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of APPL1 mRNA CTD PMID:36041667 Appl1 Rat bisphenol A decreases methylation ISO APPL1 (Homo sapiens) 6480464 bisphenol A results in decreased methylation of APPL1 gene CTD PMID:31601247 Appl1 Rat bisphenol A decreases expression ISO Appl1 (Mus musculus) 6480464 bisphenol A results in decreased expression of APPL1 mRNA CTD PMID:33221593 Appl1 Rat bisphenol A decreases expression ISO APPL1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of APPL1 protein CTD PMID:31675489 and PMID:33376534 Appl1 Rat bisphenol A multiple interactions ISO APPL1 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of APPL1 gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of APPL1 mRNA CTD PMID:28628672 and PMID:31601247 Appl1 Rat bisphenol F multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of APPL1 mRNA CTD PMID:36041667 Appl1 Rat cadmium dichloride increases expression ISO APPL1 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of APPL1 protein CTD PMID:24527689 Appl1 Rat cadmium dichloride decreases expression ISO APPL1 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of APPL1 mRNA CTD PMID:38568856 Appl1 Rat caffeine affects phosphorylation ISO APPL1 (Homo sapiens) 6480464 Caffeine affects the phosphorylation of APPL1 protein CTD PMID:35688186 Appl1 Rat chloroquine multiple interactions ISO Appl1 (Mus musculus) 6480464 Chloroquine inhibits the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein] and Chloroquine inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein] CTD PMID:25780039 Appl1 Rat cisplatin increases expression ISO Appl1 (Mus musculus) 6480464 Cisplatin results in increased expression of APPL1 mRNA CTD PMID:21151649 Appl1 Rat cisplatin decreases expression ISO APPL1 (Homo sapiens) 6480464 Cisplatin results in decreased expression of APPL1 mRNA CTD PMID:27392435 Appl1 Rat cocaine increases expression EXP 6480464 Cocaine results in increased expression of APPL1 mRNA CTD PMID:17898221 Appl1 Rat copper atom multiple interactions ISO APPL1 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in decreased expression of APPL1 mRNA CTD PMID:20971185 Appl1 Rat copper(0) multiple interactions ISO APPL1 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in decreased expression of APPL1 mRNA CTD PMID:20971185 Appl1 Rat crocidolite asbestos decreases expression ISO Appl1 (Mus musculus) 6480464 Asbestos and Crocidolite results in decreased expression of APPL1 mRNA CTD PMID:29279043 Appl1 Rat Cuprizon multiple interactions ISO APPL1 (Homo sapiens) 6480464 [Cuprizone co-treated with Haloperidol] results in increased expression of APPL1 protein CTD PMID:34122009 Appl1 Rat cyclosporin A increases expression ISO Appl1 (Mus musculus) 6480464 Cyclosporine results in increased expression of APPL1 mRNA CTD PMID:19770486 Appl1 Rat decabromodiphenyl ether decreases expression ISO APPL1 (Homo sapiens) 6480464 decabromobiphenyl ether results in decreased expression of APPL1 protein CTD PMID:31675489 Appl1 Rat dexamethasone multiple interactions ISO APPL1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of APPL1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of APPL1 mRNA CTD PMID:28628672 Appl1 Rat dibenz[a,h]anthracene decreases expression ISO Appl1 (Mus musculus) 6480464 1 more ... CTD PMID:26377693 Appl1 Rat diethylstilbestrol decreases expression ISO APPL1 (Homo sapiens) 6480464 Diethylstilbestrol results in decreased expression of APPL1 mRNA CTD PMID:36621641 Appl1 Rat doxorubicin decreases expression ISO APPL1 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of APPL1 mRNA CTD PMID:29803840 Appl1 Rat epoxiconazole increases expression ISO Appl1 (Mus musculus) 6480464 epoxiconazole results in increased expression of APPL1 mRNA CTD PMID:35436446 Appl1 Rat ethanol affects splicing ISO Appl1 (Mus musculus) 6480464 Ethanol affects the splicing of APPL1 mRNA CTD PMID:30319688 Appl1 Rat folic acid decreases expression ISO Appl1 (Mus musculus) 6480464 Folic Acid results in decreased expression of APPL1 mRNA CTD PMID:25629700 Appl1 Rat folic acid multiple interactions ISO Appl1 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of APPL1 mRNA CTD PMID:22206623 Appl1 Rat FR900359 increases phosphorylation ISO APPL1 (Homo sapiens) 6480464 FR900359 results in increased phosphorylation of APPL1 protein CTD PMID:37730182 Appl1 Rat fulvestrant multiple interactions ISO APPL1 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of APPL1 gene CTD PMID:31601247 Appl1 Rat geraniol decreases expression ISO APPL1 (Homo sapiens) 6480464 geraniol results in decreased expression of APPL1 mRNA CTD PMID:27683099 Appl1 Rat haloperidol multiple interactions ISO APPL1 (Homo sapiens) 6480464 [Cuprizone co-treated with Haloperidol] results in increased expression of APPL1 protein CTD PMID:34122009 Appl1 Rat hydrogen peroxide affects expression ISO APPL1 (Homo sapiens) 6480464 Hydrogen Peroxide affects the expression of APPL mRNA CTD PMID:20044591 Appl1 Rat indometacin multiple interactions ISO APPL1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of APPL1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of APPL1 mRNA CTD PMID:28628672 Appl1 Rat ivermectin decreases expression ISO APPL1 (Homo sapiens) 6480464 Ivermectin results in decreased expression of APPL1 protein CTD PMID:32959892 Appl1 Rat lipopolysaccharide multiple interactions ISO Appl1 (Mus musculus) 6480464 APPL1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] more ... CTD PMID:25780039 Appl1 Rat metformin multiple interactions EXP 6480464 Metformin promotes the reaction [APPL1 protein binds to RAB5A protein] CTD PMID:29991592 Appl1 Rat metformin increases expression EXP 6480464 Metformin results in increased expression of APPL1 protein CTD PMID:29991592 Appl1 Rat methyl methanesulfonate decreases expression ISO APPL1 (Homo sapiens) 6480464 Methyl Methanesulfonate results in decreased expression of APPL1 mRNA CTD PMID:23649840 Appl1 Rat N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO Appl1 (Mus musculus) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein] more ... CTD PMID:25780039 Appl1 Rat N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of APPL1 mRNA CTD PMID:25380136 Appl1 Rat paracetamol affects expression ISO Appl1 (Mus musculus) 6480464 Acetaminophen affects the expression of APPL1 mRNA CTD PMID:17562736 Appl1 Rat parathion decreases expression ISO Appl1 (Mus musculus) 6480464 Parathion results in decreased expression of APPL1 mRNA CTD PMID:34813904 Appl1 Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Appl1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of APPL1 mRNA CTD PMID:36331819 Appl1 Rat phenobarbital affects expression ISO Appl1 (Mus musculus) 6480464 Phenobarbital affects the expression of APPL1 mRNA CTD PMID:23091169 Appl1 Rat pirinixic acid increases expression ISO Appl1 (Mus musculus) 6480464 pirinixic acid results in increased expression of APPL1 mRNA CTD PMID:23811191 Appl1 Rat poly(I:C) increases degradation ISO Appl1 (Mus musculus) 6480464 Poly I-C results in increased degradation of APPL1 protein CTD PMID:25780039 Appl1 Rat poly(I:C) multiple interactions ISO Appl1 (Mus musculus) 6480464 APPL1 protein inhibits the reaction [Poly I-C results in increased expression of IL1B protein] more ... CTD PMID:25780039 Appl1 Rat resiquimod multiple interactions ISO Appl1 (Mus musculus) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resiquimod results in increased degradation of APPL1 protein] CTD PMID:25780039 Appl1 Rat resiquimod increases degradation ISO Appl1 (Mus musculus) 6480464 resiquimod results in increased degradation of APPL1 protein CTD PMID:25780039 Appl1 Rat sodium arsenate increases expression ISO Appl1 (Mus musculus) 6480464 sodium arsenate results in increased expression of APPL1 mRNA CTD PMID:21795629 Appl1 Rat sodium arsenite decreases expression ISO APPL1 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of APPL1 protein CTD PMID:30528433 Appl1 Rat sunitinib increases expression ISO APPL1 (Homo sapiens) 6480464 Sunitinib results in increased expression of APPL1 mRNA CTD PMID:31533062 Appl1 Rat tert-butyl hydroperoxide decreases expression ISO APPL1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in decreased expression of APPL1 mRNA CTD PMID:15336504 Appl1 Rat tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of APPL1 mRNA] CTD PMID:31150632 Appl1 Rat tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of APPL1 mRNA CTD PMID:31150632 Appl1 Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of APPL1 mRNA CTD PMID:34492290 Appl1 Rat titanium dioxide decreases methylation ISO Appl1 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of APPL1 gene and titanium dioxide results in decreased methylation of APPL1 promoter CTD PMID:35295148 Appl1 Rat torcetrapib increases expression ISO APPL1 (Homo sapiens) 6480464 torcetrapib results in increased expression of APPL1 mRNA CTD PMID:23228038 Appl1 Rat trametinib multiple interactions ISO Appl1 (Mus musculus) 6480464 trametinib inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein] CTD PMID:25780039 Appl1 Rat triphenyl phosphate affects expression ISO APPL1 (Homo sapiens) 6480464 triphenyl phosphate affects the expression of APPL1 mRNA CTD PMID:37042841 Appl1 Rat uranium atom affects expression ISO APPL1 (Homo sapiens) 6480464 Uranium affects the expression of APPL1 mRNA CTD PMID:15672453 Appl1 Rat valproic acid affects expression ISO APPL1 (Homo sapiens) 6480464 Valproic Acid affects the expression of APPL1 mRNA CTD PMID:25979313 Appl1 Rat vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of APPL1 mRNA CTD PMID:19015723
Imported Annotations - KEGG (archival)
(+)-schisandrin B (EXP) (1->4)-beta-D-glucan (ISO) 1,2-dimethylhydrazine (ISO) 1-naphthyl isothiocyanate (EXP) 17alpha-ethynylestradiol (EXP,ISO) 17beta-estradiol (ISO) 2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO) 2,3,7,8-tetrachlorodibenzodioxine (ISO) 2,4,6-tribromophenol (ISO) 2-butoxyethanol (ISO) 3,3',5,5'-tetrabromobisphenol A (ISO) 3-isobutyl-1-methyl-7H-xanthine (ISO) 4,4'-diaminodiphenylmethane (EXP) 4,4'-sulfonyldiphenol (EXP,ISO) aflatoxin B1 (ISO) aristolochic acid A (ISO) arsane (ISO) arsenic atom (ISO) atrazine (ISO) bafilomycin A1 (ISO) benzo[a]pyrene (ISO) beta-lapachone (ISO) bisphenol A (EXP,ISO) bisphenol F (EXP) cadmium dichloride (ISO) caffeine (ISO) chloroquine (ISO) cisplatin (ISO) cocaine (EXP) copper atom (ISO) copper(0) (ISO) crocidolite asbestos (ISO) Cuprizon (ISO) cyclosporin A (ISO) decabromodiphenyl ether (ISO) dexamethasone (ISO) dibenz[a,h]anthracene (ISO) diethylstilbestrol (ISO) doxorubicin (ISO) epoxiconazole (ISO) ethanol (ISO) folic acid (ISO) FR900359 (ISO) fulvestrant (ISO) geraniol (ISO) haloperidol (ISO) hydrogen peroxide (ISO) indometacin (ISO) ivermectin (ISO) lipopolysaccharide (ISO) metformin (EXP) methyl methanesulfonate (ISO) N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO) N-nitrosodimethylamine (EXP) paracetamol (ISO) parathion (ISO) perfluorooctane-1-sulfonic acid (ISO) phenobarbital (ISO) pirinixic acid (ISO) poly(I:C) (ISO) resiquimod (ISO) sodium arsenate (ISO) sodium arsenite (ISO) sunitinib (ISO) tert-butyl hydroperoxide (ISO) tetrachloromethane (EXP) thioacetamide (EXP) titanium dioxide (ISO) torcetrapib (ISO) trametinib (ISO) triphenyl phosphate (ISO) uranium atom (ISO) valproic acid (ISO) vinclozolin (EXP)
Appl1 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 16 2,125,234 - 2,173,457 (-) NCBI GRCr8 mRatBN7.2 16 2,118,503 - 2,166,741 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 16 2,121,255 - 2,166,692 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 16 2,125,142 - 2,173,305 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 16 3,270,829 - 3,318,993 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 16 2,131,417 - 2,179,844 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 16 2,560,103 - 2,602,035 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 16 2,563,520 - 2,602,103 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 16 2,534,851 - 2,581,754 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 16 2,180,613 - 2,227,905 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 16 2,179,191 - 2,228,173 (-) NCBI Celera 16 2,089,133 - 2,134,528 (-) NCBI Celera Cytogenetic Map 16 p16 NCBI
APPL1 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 3 57,227,729 - 57,273,471 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 3 57,227,726 - 57,278,105 (+) Ensembl GRCh38 hg38 GRCh38 GRCh37 3 57,261,757 - 57,307,499 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 3 57,236,805 - 57,282,539 (+) NCBI NCBI36 Build 36 hg18 NCBI36 Celera 3 57,227,340 - 57,273,073 (+) NCBI Celera Cytogenetic Map 3 p14.3 NCBI HuRef 3 57,310,967 - 57,356,664 (+) NCBI HuRef CHM1_1 3 57,211,913 - 57,257,646 (+) NCBI CHM1_1 T2T-CHM13v2.0 3 57,267,997 - 57,313,740 (+) NCBI T2T-CHM13v2.0
Appl1 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 14 26,640,943 - 26,692,567 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 14 26,640,945 - 26,693,189 (-) Ensembl GRCm39 Ensembl GRCm38 14 26,918,986 - 26,970,611 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 14 26,918,988 - 26,971,232 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 14 27,732,174 - 27,783,737 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 14 25,745,872 - 25,797,435 (-) NCBI MGSCv36 mm8 Celera 14 23,158,676 - 23,210,368 (-) NCBI Celera Cytogenetic Map 14 A3 NCBI cM Map 14 16.09 NCBI
Appl1 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955430 6,986,759 - 7,018,938 (+) Ensembl ChiLan1.0 ChiLan1.0 NW_004955430 6,986,977 - 7,018,938 (+) NCBI ChiLan1.0 ChiLan1.0
APPL1 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 2 57,196,344 - 57,241,732 (+) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 3 57,201,137 - 57,246,504 (+) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 3 57,161,299 - 57,206,672 (+) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 3 58,370,424 - 58,415,258 (+) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 3 58,370,430 - 58,415,258 (+) Ensembl panpan1.1 panPan2
APPL1 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 20 33,123,577 - 33,166,831 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 20 33,130,723 - 33,166,792 (-) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 20 33,051,161 - 33,094,218 (-) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 20 33,395,990 - 33,439,031 (-) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 20 33,402,695 - 33,439,040 (-) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 20 32,845,010 - 32,887,864 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 20 33,203,498 - 33,246,471 (-) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 20 33,374,797 - 33,418,067 (-) NCBI UU_Cfam_GSD_1.0
Appl1 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024405118 174,441,878 - 174,476,919 (+) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936473 7,579,780 - 7,611,923 (+) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936473 7,580,495 - 7,647,471 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
APPL1
APPL1 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 22 18,546,694 - 18,591,239 (+) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 22 18,546,751 - 18,589,552 (+) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666041 148,278,109 - 148,324,433 (-) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Appl1
.
Predicted Target Of
Count of predictions: 110 Count of miRNA genes: 83 Interacting mature miRNAs: 96 Transcripts: ENSRNOT00000018413 Prediction methods: Miranda, Targetscan Result types: miRGate_prediction
631561 Hcuc2 Hepatic copper content QTL 2 2.8 liver copper amount (VT:0003065) liver total copper weight (CMO:0001507) 16 1 39533949 Rat 1582235 Insul8 Insulin level QTL 8 3.3 0.0063 blood insulin amount (VT:0001560) calculated serum insulin level (CMO:0000359) 16 1 26727669 Rat 1549842 Bp248 Blood pressure QTL 248 0.01 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 16 380245 2995463 Rat 2307172 Activ4 Activity QTL 4 3.71 0.00023 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) 16 1 33418960 Rat 1354584 Despr6 Despair related QTL 6 3.1 0.0067 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) 16 1 39533930 Rat 1357403 Slep4 Serum leptin concentration QTL 4 3.91 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 16 1 9639137 Rat 2302380 Slep6 Serum leptin concentration QTL 6 3.36 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 16 1 32139025 Rat 12903952 Cm117 Cardiac mass QTL 117 0.001 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) 16 832380 2995225 Rat 9590151 Scort8 Serum corticosterone level QTL 8 8.45 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 16 1 30836262 Rat 1354625 Despr7 Despair related QTL 7 3.16 0.016 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) 16 1 44977551 Rat 12903954 Bw186 Body weight QTL 186 0.011 body mass (VT:0001259) body weight (CMO:0000012) 16 832380 2995225 Rat 12903955 Kidm69 Kidney mass QTL 69 0.001 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 16 832380 4227609 Rat 631830 Alc7 Alcohol consumption QTL 7 2.9 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) 16 1 26727669 Rat 7411664 Foco30 Food consumption QTL 30 11 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 16 1 44588133 Rat 1600378 Arunc4 Aerobic running capacity QTL 4 0.03 exercise endurance trait (VT:0002332) maximum distance run on treadmill (CMO:0001406) 16 380245 80345693 Rat 1600369 Hcas8 Hepatocarcinoma susceptibility QTL 8 liver integrity trait (VT:0010547) liver tumorous lesion number (CMO:0001068) 16 1 22477621 Rat 12903278 Am16 Aortic mass QTL 16 0.019 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) 16 832380 2995225 Rat 12903279 Cm115 Cardiac mass QTL 115 0.001 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) 16 832380 2995225 Rat 2325838 Bp347 Blood pressure QTL 347 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 16 1 3080679 Rat 2303566 Bw90 Body weight QTL 90 2 body mass (VT:0001259) body weight (CMO:0000012) 16 1 39533930 Rat 2312663 Slep9 Serum leptin concentration QTL 9 0.001 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 16 832236 59492508 Rat 12903281 Cm116 Cardiac mass QTL 116 0.001 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 16 832380 2995225 Rat 2312660 Bw95 Body weight QTL 95 0.05 inguinal fat pad mass (VT:0010424) inguinal fat pad weight to body weight ratio (CMO:0001253) 16 832236 59492508 Rat 2312666 Insul16 Insulin level QTL 16 0.01 blood insulin amount (VT:0001560) serum insulin level (CMO:0000358) 16 832236 59492508 Rat 634355 Rends4 Renal damage susceptibility QTL 4 0.05 kidney blood vessel morphology trait (VT:0000530) organ lesion measurement (CMO:0000677) 16 1 26727669 Rat 2293343 Glom16 Glomerulus QTL 16 7.4 kidney glomerulus integrity trait (VT:0010546) kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269) 16 832236 46053497 Rat 6903319 Bw114 Body weight QTL 114 2.7 0.0037 body mass (VT:0001259) body weight (CMO:0000012) 16 1 43534949 Rat 2312669 Stl23 Serum triglyceride level QTL 23 0.01 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 16 832236 59492508 Rat 2301404 Bp321 Blood pressure QTL 321 0.05 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 16 832380 2995225 Rat
RH129512
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 16 2,118,669 - 2,118,856 (+) MAPPER mRatBN7.2 Rnor_6.0 16 2,560,270 - 2,560,456 NCBI Rnor6.0 Rnor_5.0 16 2,535,018 - 2,535,204 UniSTS Rnor5.0 RGSC_v3.4 16 2,179,359 - 2,179,545 UniSTS RGSC3.4 Celera 16 2,086,549 - 2,086,735 UniSTS RH 3.4 Map 16 16.3 UniSTS Cytogenetic Map 16 p16 UniSTS
RH139821
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 16 2,121,529 - 2,121,738 (+) MAPPER mRatBN7.2 Rnor_6.0 16 2,563,130 - 2,563,338 NCBI Rnor6.0 Rnor_5.0 16 2,537,878 - 2,538,086 UniSTS Rnor5.0 RGSC_v3.4 16 2,182,219 - 2,182,427 UniSTS RGSC3.4 Celera 16 2,089,409 - 2,089,617 UniSTS RH 3.4 Map 16 1.6 UniSTS Cytogenetic Map 16 p16 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000018413 ⟹ ENSRNOP00000018413
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 16 2,121,255 - 2,166,692 (-) Ensembl Rnor_6.0 Ensembl 16 2,563,520 - 2,602,103 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000094750 ⟹ ENSRNOP00000084269
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 16 2,121,255 - 2,155,942 (-) Ensembl
RefSeq Acc Id:
NM_001399084 ⟹ NP_001386013
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 16 2,125,234 - 2,173,396 (-) NCBI mRatBN7.2 16 2,118,503 - 2,166,667 (-) NCBI
RefSeq Acc Id:
XM_039095136 ⟹ XP_038951064
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 16 2,125,234 - 2,173,457 (-) NCBI mRatBN7.2 16 2,118,503 - 2,166,741 (-) NCBI
Ensembl Acc Id:
ENSRNOP00000018413 ⟸ ENSRNOT00000018413
RefSeq Acc Id:
XP_038951064 ⟸ XM_039095136
- Peptide Label:
isoform X1
- UniProtKB:
A6KMK1 (UniProtKB/TrEMBL)
Ensembl Acc Id:
ENSRNOP00000084269 ⟸ ENSRNOT00000094750
RefSeq Acc Id:
NP_001386013 ⟸ NM_001399084
- UniProtKB:
D3ZWA8 (UniProtKB/TrEMBL), A6KMK1 (UniProtKB/TrEMBL)
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2016-03-22
Appl1
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Appl1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2008-04-30
RGD1309388
similar to DIP13 alpha
RGD1309388_predicted
similar to DIP13 alpha (predicted)
'predicted' is removed
2292626 APPROVED
2005-01-20
RGD1309388_predicted
similar to DIP13 alpha (predicted)
LOC290537_predicted
Symbol and Name status set to approved
1331353 APPROVED
2005-01-12
LOC290537_predicted
similar to DIP13 alpha (predicted)
Symbol and Name status set to provisional
70820 PROVISIONAL
