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Gene: Appl1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) Rattus norvegicus
Symbol: Appl1
Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
RGD ID: 1309388
Description: Predicted to have several functions, including beta-tubulin binding activity; phospholipid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; regulation of defense response; and regulation of vesicle-mediated transport. Predicted to localize to several cellular components, including cytoplasmic vesicle; ruffle; and vesicle membrane. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 14. Orthologous to human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1); PARTICIPATES IN colorectal cancer pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: MODEL
Also known as: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; DCC-interacting protein 13-alpha; LOC290537; RGD1309388; similar to DIP13 alpha
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0162,560,103 - 2,602,035 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl162,563,520 - 2,602,103 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0162,534,851 - 2,581,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4162,180,613 - 2,227,905 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1162,179,191 - 2,228,173 (-)NCBI
Celera162,089,133 - 2,134,528 (-)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Appl1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309388
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.