Appl1 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1) - Rat Genome Database

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Gene: Appl1 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1) Mus musculus
Analyze
Symbol: Appl1
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
RGD ID: 1331963
MGI Page MGI
Description: Predicted to have several functions, including beta-tubulin binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of cytokine production involved in inflammatory response; and regulation of vesicle-mediated transport. Localizes to cytoplasmic vesicle and ruffle. Is expressed in several structures, including liver; muscle tissue; spleen; stomach; and testis. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 14. Orthologous to human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1); PARTICIPATES IN colorectal cancer pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2900057D21Rik; 7330406P05Rik; adapter protein containing PH domain, PTB domain and leucine zipper motif 1; adaptor protein APPL like; AI585782; AW209077; BB022931; C88264; DCC-interacting protein 13-alpha; DIP13; DIP13 alpha; dip13-alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm19227  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391426,640,943 - 26,692,567 (-)NCBIGRCm39mm39
GRCm39 Ensembl1426,640,945 - 26,693,189 (-)Ensembl
GRCm381426,918,986 - 26,970,611 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1426,918,988 - 26,971,232 (-)EnsemblGRCm38mm10GRCm38
MGSCv371427,732,174 - 27,783,737 (-)NCBIGRCm37mm9NCBIm37
MGSCv361425,745,872 - 25,797,435 (-)NCBImm8
Celera1423,158,676 - 23,210,368 (-)NCBICelera
Cytogenetic Map14A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10862698   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15345747   PMID:15368895   PMID:15489334  
PMID:16141072   PMID:16141073   PMID:16622416   PMID:19416712   PMID:19520843   PMID:19661063   PMID:20040596   PMID:20368287   PMID:20484574   PMID:20665729   PMID:20978232   PMID:21267068  
PMID:21300805   PMID:21677750   PMID:21849472   PMID:21873635   PMID:21926268   PMID:21938726   PMID:22566644   PMID:22685329   PMID:22933778   PMID:23046739   PMID:23793716   PMID:23909487  
PMID:23921137   PMID:24813896   PMID:25328665   PMID:25568335   PMID:25780039   PMID:26261560   PMID:26445298   PMID:27219021   PMID:27246173   PMID:27300007   PMID:27478065   PMID:28011992  
PMID:28671696   PMID:28706196   PMID:29406784   PMID:29483192   PMID:29676259   PMID:29705396   PMID:29741772   PMID:30792402   PMID:30991419   PMID:31206806   PMID:31390528   PMID:32045627  
PMID:32325033  


Genomics

Comparative Map Data
Appl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391426,640,943 - 26,692,567 (-)NCBIGRCm39mm39
GRCm39 Ensembl1426,640,945 - 26,693,189 (-)Ensembl
GRCm381426,918,986 - 26,970,611 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1426,918,988 - 26,971,232 (-)EnsemblGRCm38mm10GRCm38
MGSCv371427,732,174 - 27,783,737 (-)NCBIGRCm37mm9NCBIm37
MGSCv361425,745,872 - 25,797,435 (-)NCBImm8
Celera1423,158,676 - 23,210,368 (-)NCBICelera
Cytogenetic Map14A3NCBI
APPL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl357,227,726 - 57,278,105 (+)EnsemblGRCh38hg38GRCh38
GRCh38357,227,729 - 57,273,471 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37357,261,757 - 57,307,499 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36357,236,805 - 57,282,539 (+)NCBINCBI36hg18NCBI36
Celera357,227,340 - 57,273,073 (+)NCBI
Cytogenetic Map3p14.3NCBI
HuRef357,310,967 - 57,356,664 (+)NCBIHuRef
CHM1_1357,211,913 - 57,257,646 (+)NCBICHM1_1
Appl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2162,118,503 - 2,166,741 (-)NCBI
Rnor_6.0 Ensembl162,563,520 - 2,602,103 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0162,560,103 - 2,602,035 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0162,534,851 - 2,581,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4162,180,613 - 2,227,905 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1162,179,191 - 2,228,173 (-)NCBI
Celera162,089,133 - 2,134,528 (-)NCBICelera
Cytogenetic Map16p16NCBI
Appl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554306,986,759 - 7,018,938 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554306,986,977 - 7,018,938 (+)NCBIChiLan1.0ChiLan1.0
APPL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1358,370,424 - 58,415,258 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl358,370,430 - 58,415,258 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0357,161,299 - 57,206,672 (+)NCBIMhudiblu_PPA_v0panPan3
APPL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12033,123,577 - 33,166,831 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2033,130,723 - 33,166,792 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2033,051,161 - 33,094,218 (-)NCBI
ROS_Cfam_1.02033,395,990 - 33,439,031 (-)NCBI
UMICH_Zoey_3.12032,845,010 - 32,887,864 (-)NCBI
UNSW_CanFamBas_1.02033,203,498 - 33,246,471 (-)NCBI
UU_Cfam_GSD_1.02033,374,797 - 33,418,067 (-)NCBI
Appl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118174,441,878 - 174,476,919 (+)NCBI
SpeTri2.0NW_0049364737,580,495 - 7,647,471 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APPL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1339,089,045 - 39,129,781 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11339,089,157 - 39,124,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
APPL1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12218,546,694 - 18,591,239 (+)NCBI
ChlSab1.1 Ensembl2218,546,751 - 18,589,552 (+)Ensembl
Vero_WHO_p1.0NW_023666041148,278,109 - 148,324,433 (-)NCBI
Appl1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462482231,175 - 74,252 (-)NCBI

Position Markers
AW209077  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381426,919,040 - 26,919,120UniSTSGRCm38
MGSCv371427,732,226 - 27,732,306UniSTSGRCm37
Celera1423,158,728 - 23,158,808UniSTS
Cytogenetic Map14BUniSTS
Whitehead/MRC_RH14198.81UniSTS
BB022931  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381426,922,745 - 26,922,827UniSTSGRCm38
MGSCv371427,735,931 - 27,736,013UniSTSGRCm37
Celera1423,162,437 - 23,162,519UniSTS
Cytogenetic Map14BUniSTS
Whitehead/MRC_RH14198.92UniSTS
C88264  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381426,921,645 - 26,921,732UniSTSGRCm38
MGSCv371427,734,831 - 27,734,918UniSTSGRCm37
Celera1423,161,337 - 23,161,424UniSTS
Cytogenetic Map14BUniSTS
Whitehead/MRC_RH14198.92UniSTS
AI585782  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381426,923,111 - 26,923,194UniSTSGRCm38
MGSCv371427,736,297 - 27,736,380UniSTSGRCm37
Celera1423,162,803 - 23,162,886UniSTS
Cytogenetic Map14BUniSTS
Whitehead/MRC_RH14198.76UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11532711Sluc40_msusceptibility to lung cancer 40 (mouse)14129089969Mouse
10412071Ssen3_msuseptibility to Sendai virus 3 (mouse)Not determined14129481959Mouse
1301991Wta3_mweight adult 3 (mouse)Not determined14383740537837582Mouse
4141550Dbm3_mdiabetes modifier 3 (mouse)Not determined509340539093528Mouse
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)14870000046500000Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)14870000047000000Mouse
1300779Dyscalc4_mdystrophic cardiac calcinosis 4 (mouse)Not determined141249091446491050Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined1254601848527625Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141543865949438808Mouse
4141265Appd2_mAPP associated premature death 2 (mouse)Not determined141652371130392905Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141910564753105769Mouse
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420837405121032392Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142101238271648361Mouse
14746973Manh76_mmandible shape 76 (mouse)142256526056565260Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492582457942312Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1602
Count of miRNA genes:757
Interacting mature miRNAs:971
Transcripts:ENSMUST00000036570, ENSMUST00000141599, ENSMUST00000142261, ENSMUST00000142645
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_145221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006519608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017316214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001781159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001781160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003950904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK020179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY113705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU514763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MF113398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000036570   ⟹   ENSMUSP00000042875
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1426,918,988 - 26,971,232 (-)Ensembl
RefSeq Acc Id: ENSMUST00000141599
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1426,951,126 - 26,958,511 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142261
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1426,962,597 - 26,970,463 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142645
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1426,952,419 - 26,970,500 (-)Ensembl
RefSeq Acc Id: ENSMUST00000224406
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1426,958,479 - 26,970,505 (-)Ensembl
RefSeq Acc Id: NM_145221   ⟹   NP_660256
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391426,640,945 - 26,692,508 (-)NCBI
GRCm381426,918,988 - 26,970,551 (-)NCBI
MGSCv371427,732,174 - 27,783,737 (-)RGD
Celera1423,158,676 - 23,210,368 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006519608   ⟹   XP_006519671
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391426,640,943 - 26,692,545 (-)NCBI
GRCm381426,918,986 - 26,970,587 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017316214   ⟹   XP_017171703
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391426,640,943 - 26,692,541 (-)NCBI
GRCm381426,918,986 - 26,970,586 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030248050   ⟹   XP_030103910
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391426,640,943 - 26,692,505 (-)NCBI
GRCm381426,918,986 - 26,970,548 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001781159
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391426,640,943 - 26,692,567 (-)NCBI
GRCm381426,918,986 - 26,970,611 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001781160
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391426,650,604 - 26,692,567 (-)NCBI
GRCm381426,928,647 - 26,970,611 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003950904
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391426,640,943 - 26,692,567 (-)NCBI
GRCm381426,918,986 - 26,970,611 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_660256   ⟸   NM_145221
- UniProtKB: Q8K3H0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006519671   ⟸   XM_006519608
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017171703   ⟸   XM_017316214
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030103910   ⟸   XM_030248050
- Peptide Label: isoform X3
RefSeq Acc Id: ENSMUSP00000042875   ⟸   ENSMUST00000036570
Protein Domains
BAR   PH   PID

Promoters
RGD ID:8681728
Promoter ID:EPDNEW_M18895
Type:initiation region
Name:Appl1_1
Description:Mus musculus adaptor protein, phosphotyrosine interaction, PHdomain and leucine zipper containing 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381426,970,521 - 26,970,581EPDNEW
RGD ID:6824694
Promoter ID:MM_KWN:16004
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000039316,   OTTMUST00000039350,   UC007STI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361427,783,591 - 27,784,091 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920243 AgrOrtholog
Ensembl Genes ENSMUSG00000040760 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000042875 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000036570 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APPL1_BAR UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  PTB/PI_dom UniProtKB/Swiss-Prot
KEGG Report mmu:72993 UniProtKB/Swiss-Prot
MGD MGI:1920243 ENTREZGENE
NCBI Gene 72993 ENTREZGENE
Pfam PF00169 UniProtKB/Swiss-Prot
  PID UniProtKB/Swiss-Prot
PhenoGen Appl1 PhenoGen
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot
  PID UniProtKB/Swiss-Prot
SMART PTB UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A220D9Z4_MOUSE UniProtKB/TrEMBL
  DP13A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3UJP7 UniProtKB/Swiss-Prot
  Q69ZJ9 UniProtKB/Swiss-Prot
  Q8BWZ8 UniProtKB/Swiss-Prot
  Q8VCJ8 UniProtKB/Swiss-Prot
  Q9CUW4 UniProtKB/Swiss-Prot