Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Appl1 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1) Mus musculus
Analyze
Symbol: Appl1
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Description: Predicted to have several functions, including beta-tubulin binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; regulation of defense response; and regulation of vesicle-mediated transport. Localizes to the cytoplasmic vesicle and ruffle. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 14. Orthologous to human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1); PARTICIPATES IN colorectal cancer pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2900057D21Rik; 7330406P05Rik; adapter protein containing PH domain, PTB domain and leucine zipper motif 1; adaptor protein APPL like; AI585782; AW209077; BB022931; C88264; DCC-interacting protein 13-alpha; DIP13; DIP13 alpha; dip13-alpha
Orthologs:
Related Pseudogenes: Gm19227  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1426,918,988 - 26,971,232 (-)Ensembl
GRCm381426,918,986 - 26,970,611 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371427,732,174 - 27,783,737 (-)NCBIGRCm37mm9NCBIm37
MGSCv361425,745,872 - 25,797,435 (-)NCBImm8
Celera1423,158,676 - 23,210,368 (-)NCBICelera
Cytogenetic Map14 A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Appl1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1331963
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.