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Gene: Appl1 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1) Mus musculus
Symbol: Appl1
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Description: Predicted to have several functions, including beta-tubulin binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; regulation of defense response; and regulation of vesicle-mediated transport. Localizes to the cytoplasmic vesicle and ruffle. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 14. Orthologous to human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1); PARTICIPATES IN colorectal cancer pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2900057D21Rik; 7330406P05Rik; adapter protein containing PH domain, PTB domain and leucine zipper motif 1; adaptor protein APPL like; AI585782; AW209077; BB022931; C88264; DCC-interacting protein 13-alpha; DIP13; DIP13 alpha; dip13-alpha
Related Pseudogenes: Gm19227  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1426,918,988 - 26,971,232 (-)Ensembl
GRCm381426,918,986 - 26,970,611 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371427,732,174 - 27,783,737 (-)NCBIGRCm37mm9NCBIm37
MGSCv361425,745,872 - 25,797,435 (-)NCBImm8
Celera1423,158,676 - 23,210,368 (-)NCBICelera
Cytogenetic Map14 A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Appl1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1331963
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.