Cm115 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Cm115 (Cardiac mass QTL 115) Rattus norvegicus

Symbol: Cm115
Name: Cardiac mass QTL 115
RGD ID: 12903279
Also known as: BpcaKmC16QTL
Trait: heart mass   (VT:0007028)    
Measurement Type: heart wet weight to body weight ratio   (CMO:0002408)    
LOD Score: Not Available
P Value: 0.001
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.216832,380 - 2,995,225RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0161,550,330 - 3,439,525RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0161,534,551 - 3,405,986RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.416819,369 - 3,080,748RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: SS.LEW-(D16Got3-D16Rat112)/Ayd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait
heart mass  (IDA)

Rat Strain

References

References - curated
1. Duong C, etal., Mamm Genome. 2006 Dec;17(12):1147-61. Epub 2006 Dec 1.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
9185666LOC103693859uncharacterized LOC10369385916788500945373Rat
11425421LOC108353065uncharacterized LOC10835306516831750841045Rat
40993958LOC120097392uncharacterized LOC12009739216949194961139Rat
41096323LOC120097507uncharacterized LOC120097507169975701025164Rat
1311620Zmiz1zinc finger, MIZ-type containing 11610270831232616Rat
7489016Mir3075microRNA 30751611010631101175Rat
41133681LOC120097506translation initiation factor IF-2-like1611699591173991Rat
11448061LOC10835308860S ribosomal protein L27 pseudogene1612403581242676Rat
40959642LOC120097490uncharacterized LOC1200974901612500411253697Rat
628670Ppifpeptidylprolyl isomerase F1612571971263919Rat
1306164Zcchc24zinc finger CCHC-type containing 241612745441326664Rat
7515318LOC102553299uncharacterized LOC1025532991613332711337137Rat
9247050LOC103693862U6 snRNA-associated Sm-like protein LSm5 pseudogene1613397691340198Rat
1565017RGD1565017similar to RS21-C6 protein1613929671393868Rat
1309911Anxa11annexin A111614123731457814Rat
1306662Plac9placenta associated 91614594501474222Rat
1305689Tmem254transmembrane protein 2541615039311507819Rat
1565219Cphx1cytoplasmic polyadenylated homeobox 11615338831537248Rat
1311053Dux4double homeobox 41615584301570045Rat
41244298LOC120097444uncharacterized LOC1200974441616203291626184Rat
6491687LOC100911661uncharacterized LOC1009116611616275741636979Rat
1307674Slmapsarcolemma associated protein1616672051785200Rat
41366414LOC12009743860S ribosomal protein L34-like1617373521765838Rat
41192096LOC120097665small nucleolar RNA SNORA711617519181752049Rat
1306064Dennd6aDENN domain containing 6A1618370191885420Rat
621275Arf4ADP-ribosylation factor 41618966921913267Rat
1310975Pde12phosphodiesterase 121619153861925427Rat
619990Dnah12dynein, axonemal, heavy chain 121619363542092663Rat
7728594LOC102547798protein phosphatase 1 regulatory subunit 26-like1620209972025203Rat
1596812Asb14ankyrin repeat and SOCS box-containing 141620955672123259Rat
1309388Appl1adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 11621185032166741Rat
40929646LOC120097499host cell factor C1 regulator 1-like1621248742125157Rat
1563858Hesx1HESX homeobox 11621918522193957Rat
41173772LOC120097513uncharacterized LOC1200975131622259872228141Rat
1565237Il17rdinterleukin 17 receptor D1622284672295126Rat
7556606LOC102548056uncharacterized LOC1025480561622997082301948Rat
1310672Arhgef3Rho guanine nucleotide exchange factor 31623015732581951Rat
1595469Tasortranscription activation suppressor1626068072669902Rat
1560873Ccdc66coiled-coil domain containing 661626621252694031Rat
7636032LOC102553896MLV-related proviral Env polyprotein-like1627187812727590Rat
6502340LOC100909673protein FAM173B-like1627450872745803Rat
708372Erc2ELKS/RAB6-interacting/CAST family member 21628127123673624Rat
11422894LOC108348452uncharacterized LOC1083484521628837082938011Rat
7668173LOC102553494aconitate hydratase, mitochondrial-like1628999132910508Rat
9302900LOC103693877PRAME family member 12 pseudogene1629521052958891Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
39456D16Rat8814816832236832380Ratregion
45311D16Got61231615774861577609Ratregion
1357995D16Chm682451620282402028487Ratregion
1357996D16Chm651841628444362844620Ratregion
1358001D16Chm712491622443982244647Ratregion
1358002D16Chm732231620736352073858Ratregion
1358005D16Chm272071624474262447633Ratregion
1358006D16Chm161811625525122552695Ratregion
1358007D16Chm781581626284782628636Ratregion
1358010D16Chm432001625267832526987Ratregion
1358015D16Chm672401622079092208149Ratregion
1358017D16Chm642501628030512803301Ratregion
1358025D16Chm772411626038292604070Ratregion
1358026D16Chm742171617377951738012Ratregion
1358032D16Chm692371619941331994341Ratregion
1358034D16Chm632381628514712851709Ratregion
1358035D16Chm471981622368462237044Ratregion
1358040D16Chm3621616903314903530Ratregion
1358042D16Chm662381629952252995463Ratregion
1358043D16Chm292721619303571930629Ratregion
1358044D16Chm22081626821802682388Ratregion
1358046D16Chm762481625830082583254Ratregion
1358047D16Chm412651624696432469907Ratregion
1358053D16Chm462001618664811866681Ratregion
1640551D16Got1243001619873191987618Ratregion
7206794RH12464116211614740111475632Ratregion
5039282RH1276161851612321561232341Ratregion
5037191RH989471521616685171668669Ratregion
5028641RH1257292471619129661913213Ratregion
5031728AU04734714516901026901171Ratregion
5034952AI1802021571612263471226504Ratregion
5028303DXMit10718816954374954562Ratregion
5033801RH1401741971621151752115372Ratregion
5054741RH1433981051612304781230583Ratregion
5055653RH1439251171614125151412632Ratregion
5051186RH1344892051615040781504283Ratregion
5054717RH14338526616959417959683Ratregion
5054861RH1434671091614365421436651Ratregion
5045196RH1310392081622947412294949Ratregion
5048778RH1331001961616365671636763Ratregion
5045502RH1312152171626708622671079Ratregion
5046840RH1319852201611419861142206Ratregion
5046918RH1320292071610303241030531Ratregion
5042232RH1293161651619129781913143Ratregion
5039664RH1278351951626627352662930Ratregion
5042798RH1296521931619130521913245Ratregion
5040416RH1282712051612635831263788Ratregion
5039818RH1279242061619200951920301Ratregion
7192161Hesx15961621931302193726Ratregion
5040234RH1281662181626623122662530Ratregion
5042566RH1295121871621186692118856Ratregion
5041120RH1286741851614575651457750Ratregion
5075948RH1388901781624904432490623Ratregion
5077552RH1398212091621215292121738Ratregion
5079912RH1412742121615697801569992Ratregion
5073128RH1372542201613934421393662Ratregion
5073174RH1372821831613399141340094Ratregion
5061822AW5337311911618964451896636Ratregion
5066700AU0482021301618245281824655Ratregion
5067358AU0478031781610497081049886Ratregion
5066140BF4135831041626514102651514Ratregion
5061526BE1119621511619139191914070Ratregion
5061542AA8754122101616680601668270Ratregion
5082363BE1192581561618642241864380Ratregion
5089497AU0491902391611259981126237Ratregion
5086028AA8591561951612321471232342Ratregion
5084846AI2359011121618845651884677Ratregion
5084934AA8002851011616579821658083Ratregion
5083203BI2753041661624415252441691Ratregion
5083203BI2753041661624415252441691Ratregion
5503346Hesx101621922252193143Ratregion
5501892MARC_17013-17014:1023291181:101617182811718704Ratregion
Position Markers

Flank 1: (D16Chm66)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2162,995,225 - 2,995,463 (+)MAPPER
Rnor_6.0163,439,525 - 3,439,762NCBI
Rnor_5.0163,405,986 - 3,406,223UniSTS
RGSC_v3.4163,080,748 - 3,080,985UniSTS
Celera162,957,693 - 2,957,930UniSTS
Cytogenetic Map16p16UniSTS
Flank 2: (D16Rat88)
Rat AssemblyChrPosition (strand)Source
mRatBN7.216832,236 - 832,380 (+)MAPPER
Rnor_6.0161,550,187 - 1,550,330NCBI
Rnor_5.0161,534,408 - 1,534,551UniSTS
RGSC_v3.416819,225 - 819,369RGD
RGSC_v3.416819,226 - 819,369UniSTS
RGSC_v3.116819,226 - 819,369RGD
Celera16812,123 - 812,266UniSTS
RH 3.4 Map18655.3RGD
RH 3.4 Map18655.3UniSTS
RH 2.0 Map18257.7RGD
SHRSP x BN Map161.1999RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
631561Hcuc2Hepatic copper content QTL 22.8hepatic copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2325838Bp347Blood pressure QTL 3470.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1613080679Rat
2301404Bp321Blood pressure QTL 3210.05arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)168323802995225Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)163802452995463Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
12903954Bw186Body weight QTL 1860.011body mass (VT:0001259)body weight (CMO:0000012)168323802995225Rat
12903278Am16Aortic mass QTL 160.019aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)168323802995225Rat
12903279Cm115Cardiac mass QTL 1150.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)168323802995225Rat
12903281Cm116Cardiac mass QTL 1160.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)168323802995225Rat
12903955Kidm69Kidney mass QTL 690.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)168323804227609Rat
12903952Cm117Cardiac mass QTL 1170.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)168323802995225Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general number of animals used: 9 gender: male 1599557
qtl_general also affects heart right and left ventricle mass, aortic mass, kidney mass, body mass and blood pressure 1599557
qtl_map 3.5 Mb 1599557
qtl_statistics_details software package used: ANOVA followed by Dunnett test in the SYSTAT 9 program 1599557
qtl_trait_method heart was dissected into left ventricle plus septum and right ventricle 1599557
qtl_trait_method measurement method: selected males were weaned at 21 days of age then fed 2% NaCl diet starting from 35 days of age, at 14 weeks animals were decapitated, organs removed, blotted and weighed 1599557