Bp347 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Bp347 (Blood pressure QTL 347) Rattus norvegicus

Symbol: Bp347
Name: Blood pressure QTL 347
RGD ID: 2325838
Previously known as: C16QTL
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: mean arterial blood pressure   (CMO:0000009)    
LOD Score: Not Available
P Value: 0.001
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2161 - 3,080,679RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0161 - 3,525,217RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0162,471,921 - 3,491,557RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4162,116,303 - 3,165,043RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: SS.LEW-(D16Chm36-D16Mit2)/Ayd SS.LEW-(D16Rat112-D16Chm60)/Ayd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Tasor is a candidate Gene for Bp347

Disease Annotations     Click to see Annotation Detail View
Hypotension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Modularization and epistatic hierarchy determine homeostatic actions of multiple blood pressure quantitative trait loci. Chauvet C, etal., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28.
2. Retinoblastoma-associated protein 140 as a candidate for a novel etiological gene to hypertension. Crespo K, etal., Clin Exp Hypertens. 2016;38(6):533-40. doi: 10.3109/10641963.2016.1163373. Epub 2016 Jul 8.
3. Distinct genomic replacements from Lewis correct diastolic dysfunction, attenuate hypertension, and reduce left ventricular hypertrophy in Dahl salt-sensitive rats. Deng AY, etal., J Hypertens. 2008 Oct;26(10):1935-1943.
Related QTLs

Related QTL Description Reference
Bp318 interacts with RGD:7421500
Bp310 interacts with RGD:7421500
Bp279 interacts with RGD:7421500


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1305574Polr3aRNA polymerase III subunit A164917888178Rat
621040Rps24ribosomal protein S24168953894267Rat
7525846LOC102551656uncharacterized LOC10255165616211143225944Rat
41311446LOC120097510spindlin-1-like16217000218039Rat
40961170LOC120097431uncharacterized LOC12009743116586818592862Rat
41048147LOC120097393uncharacterized LOC12009739316677492712886Rat
7724613LOC102552347uncharacterized LOC10255234716754086761766Rat
9185666LOC103693859uncharacterized LOC10369385916788500945373Rat
11425421LOC108353065uncharacterized LOC10835306516831750841045Rat
40993958LOC120097392uncharacterized LOC12009739216949194961139Rat
41096323LOC120097507uncharacterized LOC120097507169975701025164Rat
1311620Zmiz1zinc finger, MIZ-type containing 11610270831232616Rat
7489016Mir3075microRNA 30751611010631101175Rat
11448061LOC10835308860S ribosomal protein L27 pseudogene1612403581242676Rat
628670Ppifpeptidylprolyl isomerase F1612571971263919Rat
1306164Zcchc24zinc finger CCHC-type containing 241612745441326664Rat
7515318LOC102553299uncharacterized LOC1025532991613332711337137Rat
9247050Lsm5l1LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated like 11613397691340198Rat
1565017Dctpp1-ps2dCTP pyrophosphatase 1, pseudogene 21613929671393868Rat
1309911Anxa11annexin A111614123731457814Rat
1306662Plac9placenta associated 91614594501474275Rat
1305689Tmem254transmembrane protein 2541615039311507819Rat
1565219Cphx1cytoplasmic polyadenylated homeobox 11615338831537248Rat
1311053Dux4double homeobox 41615584301570045Rat
41244298LOC120097444uncharacterized LOC1200974441616203291626184Rat
6491687Dlg5ldiscs large MAGUK scaffold protein 5 like1616275741636979Rat
1307674Slmapsarcolemma associated protein1616672051785200Rat
41366414Rpl34-ps9ribosomal protein L34, pseudogene 91617373521765838Rat
41192096LOC120097665small nucleolar RNA SNORA711617519181752049Rat
1306064Dennd6aDENN domain containing 6A1618370191885420Rat
621275Arf4ARF GTPase 41618966921913267Rat
1310975Pde12phosphodiesterase 121619200621925638Rat
619990Dnah12dynein, axonemal, heavy chain 121619363542092663Rat
7728594Ppp1r26-ps1protein phosphatase 1, regulatory subunit 26, pseudogene 11620209972025203Rat
1596812Asb14ankyrin repeat and SOCS box-containing 141620955672123259Rat
1309388Appl1adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 11621185032166741Rat
1563858Hesx1HESX homeobox 11621918522193957Rat
41173772LOC120097513uncharacterized LOC1200975131622259872228141Rat
1565237Il17rdinterleukin 17 receptor D1622284382295122Rat
7556606LOC102548056uncharacterized LOC1025480561622997082301948Rat
1310672Arhgef3Rho guanine nucleotide exchange factor 31623015732581951Rat
1595469Tasortranscription activation suppressor1626068072669902Rat
1560873Ccdc66coiled-coil domain containing 661626621252694031Rat
7636032Envl-ps12MLV-related proviral Env polyprotein-like, pseudogene 121627187812727590Rat
6502340Atpsckmt-ps1ATP synthase c subunit lysine N-methyltransferase, pseudogene 11627450872745803Rat
708372Erc2ELKS/RAB6-interacting/CAST family member 21628127123673624Rat
11422894LOC108348452uncharacterized LOC1083484521628837082938011Rat
7668173Aco2-ps1aconitase 2, pseudogene 11628999132910508Rat
9302900LOC103693877PRAME family member 12 pseudogene1629521052958891Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
36892D16Rat1212416380245380356Ratregion
39456D16Rat8814816832236832380Ratregion
42409D16Rat11224616110590110831Ratregion
60126D16Got517216197699197871Ratregion
45308D16Got217616197415197591Ratregion
45311D16Got61231615774861577609Ratregion
1357995D16Chm682451620282402028487Ratregion
1357996D16Chm651841628444362844620Ratregion
1357997D16Chm5221016525912526122Ratregion
1357999D16Chm1419316127141127338Ratregion
1358001D16Chm712491622443982244647Ratregion
1358002D16Chm732231620736352073858Ratregion
1358005D16Chm272071624474262447633Ratregion
1358006D16Chm161811625525122552695Ratregion
1358007D16Chm781581626284782628636Ratregion
1358009D16Chm2620116630050630247Ratregion
1358010D16Chm432001625267832526987Ratregion
1358011D16Chm3221716132366132583Ratregion
1358012D16Chm3418916125494125683Ratregion
1358015D16Chm672401622079092208149Ratregion
1358017D16Chm642501628030512803301Ratregion
1358022D16Chm3120516305507305714Ratregion
1358024D16Chm3319816187648187846Ratregion
1358025D16Chm772411626038292604070Ratregion
1358026D16Chm742171617377951738012Ratregion
1358027D16Chm2520616538187538394Ratregion
1358029D16Chm5519516829968830657Ratregion
1358029D16Chm5519516830462830657Ratregion
1358032D16Chm692371619941331994341Ratregion
1358033D16Chm2419316127141127338Ratregion
1358034D16Chm632381628514712851709Ratregion
1358035D16Chm471981622368462237044Ratregion
1358036D16Chm23190168852488716Ratregion
1358037D16Chm622916244020244249Ratregion
1358040D16Chm3621616903314903530Ratregion
1358041D16Chm602611630804163080679Ratregion
1358042D16Chm662381629952252995463Ratregion
1358043D16Chm292721619303571930629Ratregion
1358044D16Chm22081626821802682388Ratregion
1358045D16Chm5420116503575503776Ratregion
1358046D16Chm762481625830082583254Ratregion
1358047D16Chm412651624696432469907Ratregion
1358048D16Chm3720116578688578891Ratregion
1358051D16Chm720816756765756975Ratregion
1358053D16Chm462001618664811866681Ratregion
1631551D16Got1202791630199703020251Ratregion
1640551D16Got1243001619873191987618Ratregion
1638037D16Got11312116756789756912Ratregion
7206792RH12432644916217250217699Ratregion
7206794RH12464116211614740111475632Ratregion
5039282RH1276161851612321561232341Ratregion
5037191RH989471521616685171668669Ratregion
5028641RH1257292471619129661913213Ratregion
5031728AU04734714516901026901171Ratregion
5034952AI1802021571612263471226504Ratregion
5030313BE10569815716179607179764Ratregion
5028303DXMit10718816954374954562Ratregion
5033801RH1401741971621151752115372Ratregion
5031161BF41321919116536380536571Ratregion
5054741RH1433981051612304781230583Ratregion
5055653RH1439251171614125151412632Ratregion
5058882BE10255917816470488470666Ratregion
5051186RH1344892051615040781504283Ratregion
5054325RH143159209164926249471Ratregion
5054717RH14338526616959417959683Ratregion
5054861RH1434671091614365421436651Ratregion
5045196RH1310392081622947412294949Ratregion
5048778RH1331001961616365671636763Ratregion
5045502RH1312152171626708622671079Ratregion
5046840RH1319852201611419861142206Ratregion
5046918RH1320292071610303241030531Ratregion
5042232RH1293161651619129781913143Ratregion
5039664RH1278351951626627352662930Ratregion
5042798RH1296521931619130521913245Ratregion
5040416RH1282712051612635831263788Ratregion
5039818RH1279242061619200951920301Ratregion
7192161Hesx15961621931302193726Ratregion
5040234RH1281662181626623122662530Ratregion
5042566RH1295121871621186692118856Ratregion
5041120RH1286741851614575651457750Ratregion
5075370RH13855513016683702683832Ratregion
5075948RH1388901781624904432490623Ratregion
5077552RH1398212091621215292121738Ratregion
5079912RH1412742121615697801569992Ratregion
5078828RH140575216165005550271Ratregion
5073128RH1372542201613934421393662Ratregion
5073174RH1372821831613399141340094Ratregion
5061822AW5337311911618964451896636Ratregion
5066700AU0482021301618245281824655Ratregion
5067358AU0478031781610497081049886Ratregion
5061938BE112185150169490595055Ratregion
5065648BF40614824116521140521380Ratregion
5066140BF4135831041626514102651514Ratregion
5061526BE1119621511619139191914070Ratregion
5061542AA8754122101616680601668270Ratregion
5082363BE1192581561618642241864380Ratregion
5089497AU0491902391611259981126237Ratregion
5086028AA8591561951612321471232342Ratregion
5084846AI2359011121618845651884677Ratregion
5084934AA8002851011616579821658083Ratregion
5083203BI2753041661624415252441691Ratregion
5083203BI2753041661624415252441691Ratregion
5503346Hesx101621922252193143Ratregion
5506763G4522318316454227454410Ratregion
5501892MARC_17013-17014:1023291181:101617182811718704Ratregion
Position Markers

Flank 1: (D16Chm48)
Rat AssemblyChrPosition (strand)Source
Rnor_5.0162,471,921 - 2,472,139NCBI
RGSC_v3.4162,116,303 - 2,116,534UniSTS
Celera162,023,329 - 2,023,560UniSTS
Cytogenetic Map16p16UniSTS
Flank 2: (D16Chm60)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2163,080,416 - 3,080,679 (+)MAPPER
Rnor_6.0163,524,957 - 3,525,217NCBI
Rnor_5.0163,491,297 - 3,491,557UniSTS
RGSC_v3.4163,164,783 - 3,165,043UniSTS
Celera163,029,112 - 3,029,372UniSTS
Cytogenetic Map16p16UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)163802452995463Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
12903952Cm117Cardiac mass QTL 1170.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)168323802995225Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
12903954Bw186Body weight QTL 1860.011body mass (VT:0001259)body weight (CMO:0000012)168323802995225Rat
12903955Kidm69Kidney mass QTL 690.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)168323804227609Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
12903278Am16Aortic mass QTL 160.019aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)168323802995225Rat
12903279Cm115Cardiac mass QTL 1150.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)168323802995225Rat
631524Bp75Blood pressure QTL 750.05arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)161110831Rat
2325838Bp347Blood pressure QTL 3470.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1613080679Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
12903281Cm116Cardiac mass QTL 1160.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)168323802995225Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301404Bp321Blood pressure QTL 3210.05arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)168323802995225Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general measurement method: at 21 days rats were weaned, maintained on 0.2% NaCl diet; at 35 days of age they were fed 2% NaCl diet; telemetry probes were implanted at 56 days of age; systolic, diastolic and mean arterial pressures were measured 2301185
qtl_general software used: ANOVA and Dunnett 2301185
qtl_general number of animals used: 7 males 2301185
qtl_map this QTL entends 2.27 Mb 2301185