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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PDE12 mRNA] | CTD | PMID:31150632 | 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane | increases expression | ISO | RGD:1322180 | 6480464 | 2 more ... | CTD | PMID:25575267 | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:1322180 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of PDE12 mRNA | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | RGD:1322180 | 6480464 | Estradiol results in increased expression of PDE12 mRNA | CTD | PMID:25575267 | 17beta-estradiol | increases expression | ISO | RGD:1606683 | 6480464 | Estradiol results in increased expression of PDE12 mRNA | CTD | PMID:31614463 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | RGD:1606683 | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1322180 | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of PDE12 mRNA | CTD | PMID:25975270 | 2,4,6-tribromophenol | decreases expression | ISO | RGD:1606683 | 6480464 | 2 more ... | CTD | PMID:31675489 | 2-methylcholine | affects expression | ISO | RGD:1606683 | 6480464 | beta-methylcholine affects the expression of PDE12 mRNA | CTD | PMID:21179406 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | RGD:1606683 | 6480464 | tetrabromobisphenol A results in decreased expression of PDE12 protein | CTD | PMID:31675489 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of PDE12 mRNA | CTD | PMID:24780913 | aflatoxin B1 | increases expression | ISO | RGD:1322180 | 6480464 | Aflatoxin B1 results in increased expression of PDE12 mRNA | CTD | PMID:19770486 | antirheumatic drug | decreases expression | ISO | RGD:1606683 | 6480464 | Antirheumatic Agents results in decreased expression of PDE12 mRNA | CTD | PMID:24449571 | aristolochic acid | decreases expression | ISO | RGD:1606683 | 6480464 | aristolochic acid I results in decreased expression of PDE12 mRNA | CTD | PMID:33212167 | atrazine | decreases expression | ISO | RGD:1606683 | 6480464 | Atrazine results in decreased expression of PDE12 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | increases expression | ISO | RGD:1322180 | 6480464 | Benzo(a)pyrene results in increased expression of PDE12 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | affects methylation | ISO | RGD:1606683 | 6480464 | Benzo(a)pyrene affects the methylation of PDE12 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | RGD:1606683 | 6480464 | Benzo(a)pyrene results in increased expression of PDE12 mRNA | CTD | PMID:26238291 | bisphenol A | increases expression | ISO | RGD:1322180 | 6480464 | bisphenol A results in increased expression of PDE12 mRNA | CTD | PMID:25575267 | bisphenol A | decreases expression | ISO | RGD:1606683 | 6480464 | bisphenol A results in decreased expression of PDE12 protein | CTD | PMID:31675489 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PDE12 mRNA | CTD | PMID:30816183, PMID:32528016 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PDE12 mRNA | CTD | PMID:25181051 | carbon nanotube | increases expression | ISO | RGD:1322180 | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | crocidolite asbestos | increases expression | ISO | RGD:1606683 | 6480464 | Asbestos, Crocidolite results in increased expression of PDE12 mRNA | CTD | PMID:18687144 | cyclosporin A | increases expression | ISO | RGD:1606683 | 6480464 | Cyclosporine results in increased expression of PDE12 mRNA | CTD | PMID:25562108 | decabromodiphenyl ether | increases expression | EXP | | 6480464 | decabromobiphenyl ether results in increased expression of PDE12 mRNA | CTD | PMID:23914054 | decabromodiphenyl ether | decreases expression | ISO | RGD:1606683 | 6480464 | decabromobiphenyl ether results in decreased expression of PDE12 protein | CTD | PMID:31675489 | deoxynivalenol | increases expression | ISO | RGD:1606683 | 6480464 | deoxynivalenol results in increased expression of PDE12 mRNA | CTD | PMID:31863870 | diethylstilbestrol | increases expression | ISO | RGD:1322180 | 6480464 | Diethylstilbestrol results in increased expression of PDE12 mRNA | CTD | PMID:25575267 | dioxygen | multiple interactions | ISO | RGD:1322180 | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PDE12 mRNA | CTD | PMID:30529165 | dorsomorphin | multiple interactions | ISO | RGD:1606683 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE12 mRNA | CTD | PMID:27188386 | doxorubicin | increases expression | ISO | RGD:1606683 | 6480464 | Doxorubicin results in increased expression of PDE12 mRNA | CTD | PMID:29803840 | enzyme inhibitor | multiple interactions | ISO | RGD:1606683 | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PDE12 protein | CTD | PMID:23301498 | estriol | increases expression | ISO | RGD:1322180 | 6480464 | Estriol results in increased expression of PDE12 mRNA | CTD | PMID:25575267 | ethanol | affects splicing | ISO | RGD:1322180 | 6480464 | Ethanol affects the splicing of PDE12 mRNA | CTD | PMID:30319688 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of PDE12 mRNA | CTD | PMID:30307764 | folic acid | decreases expression | ISO | RGD:1322180 | 6480464 | Folic Acid results in decreased expression of PDE12 mRNA | CTD | PMID:25629700 | ivermectin | decreases expression | ISO | RGD:1606683 | 6480464 | Ivermectin results in decreased expression of PDE12 protein | CTD | PMID:32959892 | ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of PDE12 mRNA | CTD | PMID:20080153 | nitrofen | increases expression | EXP | | 6480464 | nitrofen results in increased expression of PDE12 mRNA | CTD | PMID:26720608 | paracetamol | affects expression | ISO | RGD:1322180 | 6480464 | Acetaminophen affects the expression of PDE12 mRNA | CTD | PMID:17562736 | perfluorooctanoic acid | increases expression | ISO | RGD:1606683 | 6480464 | perfluorooctanoic acid results in increased expression of PDE12 protein | CTD | PMID:26879310 | potassium dichromate | increases expression | ISO | RGD:1322180 | 6480464 | Potassium Dichromate results in increased expression of PDE12 mRNA | CTD | PMID:23608068 | propiconazole | increases expression | ISO | RGD:1322180 | 6480464 | propiconazole results in increased expression of PDE12 mRNA | CTD | PMID:21278054 | quercetin | decreases expression | ISO | RGD:1606683 | 6480464 | Quercetin results in decreased expression of PDE12 mRNA | CTD | PMID:21632981 | resveratrol | multiple interactions | ISO | RGD:1606683 | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of PDE12 mRNA | CTD | PMID:23557933 | rotenone | increases expression | ISO | RGD:1322180 | 6480464 | Rotenone results in increased expression of PDE12 mRNA | CTD | PMID:32937126 | SB 431542 | multiple interactions | ISO | RGD:1606683 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE12 mRNA | CTD | PMID:27188386 | tetrachloromethane | increases expression | ISO | RGD:1322180 | 6480464 | Carbon Tetrachloride results in increased expression of PDE12 mRNA | CTD | PMID:27339419, PMID:31919559 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of PDE12 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PDE12 mRNA] | CTD | PMID:31150632 | trimellitic anhydride | increases expression | ISO | RGD:1322180 | 6480464 | trimellitic anhydride results in increased expression of PDE12 mRNA | CTD | PMID:19042947 | tungsten | increases expression | ISO | RGD:1322180 | 6480464 | Tungsten results in increased expression of PDE12 mRNA | CTD | PMID:30912803 | valproic acid | affects expression | ISO | RGD:1606683 | 6480464 | Valproic Acid affects the expression of PDE12 mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | RGD:1606683 | 6480464 | Valproic Acid results in increased expression of PDE12 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | RGD:1606683 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE12 mRNA | CTD | PMID:27188386 | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of PDE12 gene | CTD | PMID:31682807 | |