Pde12 (phosphodiesterase 12) - Rat Genome Database

Name: Pde12
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Pde12 (phosphodiesterase 12) Rattus norvegicus

Analyze

Symbol:

Pde12

Name:

phosphodiesterase 12

RGD ID:

1310975

Description:

Predicted to have 3'-5'-exoribonuclease activity. Predicted to be involved in several processes, including RNA metabolic process; cellular response to cytokine stimulus; and regulation of mitochondrial mRNA stability. Predicted to localize to mitochondrial matrix. Orthologous to human PDE12 (phosphodiesterase 12); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

2',5'-phosphodiesterase 12; 2'-PDE; 2-PDE; LOC306231; LRRGT00074; mitochondrial deadenylase; RGD1310975; similar to CG31759-PA

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PDE12 (phosphodiesterase 12)	HGNC	Ensembl, HomoloGene, NCBI, Panther
Mus musculus (house mouse):	Pde12 (phosphodiesterase 12)	HGNC	NCBI, HomoloGene, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Pde12 (phosphodiesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PDE12 (phosphodiesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PDE12 (phosphodiesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pde12 (phosphodiesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PDE12 (phosphodiesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	PDE12 (phosphodiesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pde12 (phosphodiesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CNOT6L (CCR4-NOT transcription complex subunit 6 like)	HGNC	Inparanoid
Alliance orthologs ³
Mus musculus (house mouse):	Pde12 (phosphodiesterase 12)	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Homo sapiens (human):	PDE12 (phosphodiesterase 12)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	pde-12	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG31759	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	1,915,386 - 1,925,427 (-)	NCBI
Rnor_6.0 Ensembl	16	2,357,028 - 2,367,253 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	16	2,357,028 - 2,367,069 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	16	2,332,374 - 2,343,524 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	1,974,440 - 1,984,481 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	1,980,152 - 1,984,665 (-)	NCBI
Celera	16	1,884,218 - 1,894,257 (-)	NCBI		Celera
Cytogenetic Map	16	p16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiovirus Infections (ISO)

respiratory syncytial virus infectious disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-methylcholine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

deoxynivalenol (ISO)

diethylstilbestrol (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

estriol (ISO)

ethanol (ISO)

fenvalerate (EXP)

folic acid (ISO)

ketamine (EXP)

nitrofen (EXP)

paracetamol (ISO)

perfluorooctanoic acid (ISO)

potassium dichromate (ISO)

propiconazole (ISO)

quercetin (ISO)

SB 431542 (ISO)

tetrachloromethane (EXP,ISO)

trimellitic anhydride (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to dsRNA (IEA,ISO)

cellular response to interferon-alpha (IEA,ISO)

cellular response to interferon-gamma (IEA,ISO)

mitochondrial mRNA catabolic process (IEA,ISO)

mRNA processing (IEA)

negative regulation of cell death (IEA,ISO)

negative regulation of oxidative phosphorylation (IEA,ISO)

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (IBA,IEA,ISO)

nucleic acid phosphodiester bond hydrolysis (ISO)

positive regulation of viral genome replication (IEA,ISO)

regulation of mitochondrial mRNA stability (IEA,ISO)

RNA phosphodiester bond hydrolysis, exonucleolytic (IEA,ISO)

Cellular Component

mitochondrial matrix (IEA,ISO)

mitochondrion (IBA)

Molecular Function

3'-5'-exoribonuclease activity (IBA,IEA,ISO)

exonuclease activity (ISO)

metal ion binding (IEA)

poly(A)-specific ribonuclease activity (IEA)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	RGD automated import pipeline for gene-chemical interactions
3.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15231837	PMID:18614015	PMID:21245038	PMID:21666256	PMID:22285541	PMID:22871113

Genomics

Comparative Map Data

Pde12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	1,915,386 - 1,925,427 (-)	NCBI
Rnor_6.0 Ensembl	16	2,357,028 - 2,367,253 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	16	2,357,028 - 2,367,069 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	16	2,332,374 - 2,343,524 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	1,974,440 - 1,984,481 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	1,980,152 - 1,984,665 (-)	NCBI
Celera	16	1,884,218 - 1,894,257 (-)	NCBI		Celera
Cytogenetic Map	16	p16	NCBI

PDE12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	3	57,556,274 - 57,566,848 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	3	57,556,274 - 57,656,495 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	3	57,542,001 - 57,642,222 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	57,517,044 - 57,522,720 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	3	57,555,770 - 57,561,606 (+)	NCBI
Cytogenetic Map	3	p14.3	NCBI
HuRef	3	57,639,405 - 57,645,202 (+)	NCBI		HuRef
CHM1_1	3	57,492,074 - 57,592,295 (+)	NCBI		CHM1_1

Pde12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	26,385,272 - 26,391,001 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	14	26,381,113 - 26,391,038 (-)	Ensembl
GRCm38	14	26,664,117 - 26,669,846 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	26,659,958 - 26,669,883 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	27,483,603 - 27,489,332 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	14	25,497,301 - 25,503,030 (-)	NCBI			mm8
Celera	14	22,906,785 - 22,912,518 (-)	NCBI		Celera
Cytogenetic Map	14	A3	NCBI

Pde12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	7,272,765 - 7,277,726 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	7,272,911 - 7,277,726 (+)	NCBI	ChiLan1.0	ChiLan1.0

PDE12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	58,695,951 - 58,703,257 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	58,696,083 - 58,699,719 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	3	57,489,602 - 57,502,240 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

PDE12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	32,884,819 - 32,890,995 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	32,886,972 - 32,890,890 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	32,812,998 - 32,819,199 (-)	NCBI
ROS_Cfam_1.0	20	33,157,456 - 33,163,631 (-)	NCBI
UMICH_Zoey_3.1	20	32,613,238 - 32,619,411 (-)	NCBI
UNSW_CanFamBas_1.0	20	32,971,314 - 32,977,518 (-)	NCBI
UU_Cfam_GSD_1.0	20	33,142,175 - 33,148,378 (-)	NCBI

Pde12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	174,755,477 - 174,759,271 (+)	NCBI
SpeTri2.0	NW_004936473	7,894,026 - 7,897,844 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDE12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	39,395,541 - 39,402,650 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	39,395,517 - 39,402,653 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	43,327,075 - 43,330,812 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDE12
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	18,863,676 - 18,869,778 (+)	NCBI
ChlSab1.1 Ensembl	22	18,863,696 - 18,867,736 (+)	Ensembl

Pde12
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624821	306,055 - 311,101 (+)	NCBI

Position Markers

RH127924

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	1,920,095 - 1,920,301 (+)	MAPPER
Rnor_6.0	16	2,361,738 - 2,361,943	NCBI	Rnor6.0
Rnor_5.0	16	2,337,084 - 2,337,289	UniSTS	Rnor5.0
RGSC_v3.4	16	1,979,150 - 1,979,355	UniSTS	RGSC3.4
Celera	16	1,888,928 - 1,889,133	UniSTS
RH 3.4 Map	16	16.3	UniSTS
Cytogenetic Map	16	p16	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2325838	Bp347	Blood pressure QTL 347		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	1	3525217	Rat
1357403	Slep4	Serum leptin concentration QTL 4	3.91		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	10660736	Rat
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	24228366	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	27556253	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	27556253	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	27556253	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	31816439	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	33160624	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	34465490	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	41240937	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	41240937	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		hepatic copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	41240957	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	244593	45244593	Rat
1549842	Bp248	Blood pressure QTL 248		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	1090054	3439762	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	1090054	86162972	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1340741	46340741	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	1550187	49247447	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	1550187	63210301	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1550187	63210301	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	1550187	63210301	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	1550187	63210301	Rat
2301404	Bp321	Blood pressure QTL 321		0.05	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	1550330	3439525	Rat
12903278	Am16	Aortic mass QTL 16		0.019	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	16	1550330	3439525	Rat
12903279	Cm115	Cardiac mass QTL 115		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	16	1550330	3439525	Rat
12903281	Cm116	Cardiac mass QTL 116		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	16	1550330	3439525	Rat
12903952	Cm117	Cardiac mass QTL 117		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	16	1550330	3439525	Rat
12903954	Bw186	Body weight QTL 186		0.011	body mass (VT:0001259)	body weight (CMO:0000012)	16	1550330	3439525	Rat
12903955	Kidm69	Kidney mass QTL 69		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	16	1550330	5013802	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1728297	46728297	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	255
Count of miRNA genes:	170
Interacting mature miRNAs:	185
Transcripts:	ENSRNOT00000017800, ENSRNOT00000051486
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	4	23	8	16	8			14	22	16	8
Low	2	39	34	33	3	33	8	11	60	13	25	3	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY387060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000079625 ⟹ ENSRNOP00000074876

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	2,357,028 - 2,367,069 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000083573 ⟹ ENSRNOP00000073047

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	2,362,741 - 2,367,253 (-)	Ensembl

RefSeq Acc Id:

NM_001013998 ⟹ NP_001014020

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	1,915,386 - 1,925,427 (-)	NCBI
Rnor_6.0	16	2,357,028 - 2,367,069 (-)	NCBI
Rnor_5.0	16	2,332,374 - 2,343,524 (-)	NCBI
RGSC_v3.4	16	1,974,440 - 1,984,481 (-)	RGD
Celera	16	1,884,218 - 1,894,257 (-)	RGD

Sequence:

show sequence

ATGGAGCGCGCGGTGGTGCGCTGTGTGCCCTCGGAGCCCAAGCTCAGCCTGTCTTTTGCGTTGG
CCGACGGCAGCCACAAAAACATGCAGCGGGACCAGAGCGAGCCTCTGGGCCGTGCTCTCAGCCG
GATCGCTACCAACGCCCTCAAGGGGCACGCTAAGGTAGCGGCTGCCAAAAAGAGCAGGAAGAAC
CGAGCCCACTCGAGCGGTGGCGCGGCCTGCGCGGCGACAGGGTCTGAACCGGCTGCGACCTGCG
AGCCGGTGGTGAAGCTGTACTACCGGGAGGAGGCGGTAGCTGAGGATGTGCTCAATGTGGACGC
CTGGCAGGACGGAGCGGTGCTGCAGATCGGCGATGTCAAGTACAAGGTGGAGCGCAACCCGCCT
GCCTTCACGGAGCTACAATTGCCGCGCTACATCATGGCTGGCTTCCCGGTGTGTCCCAAACTCG
GTCTGGAATTTGGGGATCCCGCCAGCTCCGTGTTCCGCTGGTACAAGGAAGTCAAACCCGGGGC
GGCAGAACCTGGAGACAGCGGTCTCGCGTCATCGTCTCACTCTTTGCAGTCTTCAGCTTGGATC
GAGACGGGTGTGGACGAGCGCGTTTACACCCCGTGCAATGCTGACATCGGGCTACGGCTCAAGC
TTCACTGCACGCCGGGCAATGGGCAGCGCTTCGGGCCAAGCCGCGAGCTAGAGAGCGTGTGCCC
GGTGGAGGCCGGGCCTGGCACCTGCACTTTTGACCATCGACATCTATACACCAAGAAGGTGACA
GAGGACTCTTTCATCCGCACTGTCTCCTACAACATCCTGGCAGACACGTACGCCCAGACTGAGT
TTTCTCGGACAGTCCTGTACCCGTACTGTGCCCCCTACGCCCTGGAGCTTGACTACCGCCAGAA
CCTTATTCAAAAGGAGCTCACAGGCTACAACGCAGACCTCATCTGTTTGCAGGAGGTGGACCGC
GCAGTGTTCTCGGACAGCTTGGTACCGGCCCTAGAGGCCTTCGGGCTGGAGGGTGTGTTCCGAA
TCAAGCAGCACGAAGGCCTGGCCACTTTCTACCGGAAGTCGAAGTTCAGGCTCCTTAGCCAACA
TGACATTTCTTTTCAAGAAGCCCTGAAGTCGGACCCACTGCACAAAGAATTACTAGAGAAACTG
GCTTTGAACCCGTTAGCACAGGAGAAAGTACTCCAGAGATCGTCTGTCCTTCAGATTTCAGTTC
TTCAGTCTACCACGGACTCTTCTAAAAAGATCTGTGTTGCTAATACTCATCTCTACTGGCACCC
AAAAGGTGGATACATTCGTCTCATTCAAATGGCAGCAGCCTTGGTTCACATTAGACATGTTTCC
TGTGATCTATATCCTGGCATACCAGTTATATTTTGTGGAGACTTTAATAGCACACCATCAACAG
GAATGTATCATTTTGTCATCAATGGCAGCGTTCCGGAGGATCATGAAGACTGGGCTTCCAATGG
GGAGGAGGAGAGATGTGGCATGTCTCTCACACACTGTTTCAAACTGAAAAGCGCTTGTGGTGAA
CCTGCCTACACAAATTATGTCGGTGGCTTTCATGGATGTCTCGATTACATTTTCATTGACTTAA
ATGCTTTAGAGGTTGAACAGACATTTCAGGATATTCAGATAACGAAGTGTAAAGATTTGACTCC
AGCATACAGATATCAGGATGATTGGATACAAAGCCCACCTTCAGGAATTGCTACTTTTATTTAT
GAGTTTGTGCCAAGTGGGAAAGGTTTTACTGCTTCCTTTAAAGAAAACTGTGAATATCAAAGAC
TAATGGACATTCATACTGCTTACACTTATAGACTAATGGACATTCATACTGCTTATACTTATGG
ATTAATGGACATTCATACTGCTTATACTTATGGATTAATGGACATTCATACTGTTTATACTTAT
GGATTAATGGACATTCATACTGCTTATACTTATGGATTAATGGACATTCATACTGCTTCCACTA
GTAATTTTGCTAACATTTGTGTACAAGTTCTGTGTGGGTGTCTTAATTTCTCTTGGGCAGTCCT
TTGCCATGGGCAGAACTCTTGGGTCATGTGGAAACACTTACCTTTTGAGAAATTGCTAGAGTAT
TACTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001014020	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79396	(Get FASTA)	NCBI Sequence Viewer
	AAQ91030	(Get FASTA)	NCBI Sequence Viewer
	EDL75071	(Get FASTA)	NCBI Sequence Viewer
	Q6AXQ5	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001014020 ⟸ NM_001013998

- UniProtKB:

Q6TUH0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MERAVVRCVPSEPKLSLSFALADGSHKNMQRDQSEPLGRALSRIATNALKGHAKVAAAKKSRKN
RAHSSGGAACAATGSEPAATCEPVVKLYYREEAVAEDVLNVDAWQDGAVLQIGDVKYKVERNPP
AFTELQLPRYIMAGFPVCPKLGLEFGDPASSVFRWYKEVKPGAAEPGDSGLASSSHSLQSSAWI
ETGVDERVYTPCNADIGLRLKLHCTPGNGQRFGPSRELESVCPVEAGPGTCTFDHRHLYTKKVT
EDSFIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADLICLQEVDR
AVFSDSLVPALEAFGLEGVFRIKQHEGLATFYRKSKFRLLSQHDISFQEALKSDPLHKELLEKL
ALNPLAQEKVLQRSSVLQISVLQSTTDSSKKICVANTHLYWHPKGGYIRLIQMAAALVHIRHVS
CDLYPGIPVIFCGDFNSTPSTGMYHFVINGSVPEDHEDWASNGEEERCGMSLTHCFKLKSACGE
PAYTNYVGGFHGCLDYIFIDLNALEVEQTFQDIQITKCKDLTPAYRYQDDWIQSPPSGIATFIY
EFVPSGKGFTASFKENCEYQRLMDIHTAYTYRLMDIHTAYTYGLMDIHTAYTYGLMDIHTVYTY
GLMDIHTAYTYGLMDIHTASTSNFANICVQVLCGCLNFSWAVLCHGQNSWVMWKHLPFEKLLEY
Y

hide sequence

RefSeq Acc Id:

ENSRNOP00000074876 ⟸ ENSRNOT00000079625

RefSeq Acc Id:

ENSRNOP00000073047 ⟸ ENSRNOT00000083573

Protein Domains

Endo/exonuclease/phosphatase

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699900

Promoter ID:

EPDNEW_R10420

Type:

multiple initiation site

Name:

Pde12_1

Description:

phosphodiesterase 12

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	2,367,264 - 2,367,324	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310975	AgrOrtholog
Ensembl Genes	ENSRNOG00000059442	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000073047	UniProtKB/Swiss-Prot
	ENSRNOP00000074876	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000079625	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000083573	UniProtKB/Swiss-Prot
Gene3D-CATH	3.60.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7112419	IMAGE-MGC_LOAD
InterPro	Endo/exonu/phosph_ase_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Endo/exonuclease/phosphatase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:306231	UniProtKB/TrEMBL
MGC_CLONE	MGC:94924	IMAGE-MGC_LOAD
NCBI Gene	306231	ENTREZGENE
Pfam	Exo_endo_phos	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pde12	PhenoGen
Superfamily-SCOP	SSF56219	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	PDE12_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q6TUH0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-05-19	Pde12	phosphodiesterase 12	RGD1310975	similar to CG31759-PA	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1310975	similar to CG31759-PA	RGD1310975_predicted	similar to CG31759-PA (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1310975_predicted	similar to CG31759-PA (predicted)	LOC306231_predicted	similar to CG31759-PA (predicted)	Symbol and Name status set to approved	1331353	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD