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Gene: Ppif (peptidylprolyl isomerase F) Rattus norvegicus
Symbol: Ppif
Name: peptidylprolyl isomerase F
RGD ID: 628670
Description: Exhibits cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in regulation of apoptotic process and regulation of mitochondrial membrane permeability. Localizes to mitochondrial inner membrane and mitochondrial matrix. Predicted to colocalize with mitochondrial proton-transporting ATP synthase complex. Orthologous to human PPIF (peptidylprolyl isomerase F); PARTICIPATES IN toxoplasmosis pathway; INTERACTS WITH 1,1'-azobis(N,N-dimethylformamide); 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
Also known as: cyclophilin D; cyclophilin F; CyP-D; CypD; MGC93084; Peptidyl-prolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase F, mitochondrial; peptidyl-prolyl cis-trans isomerase, mitochondrial; peptidylprolyl isomerase F (cyclophilin F); PPIase; PPIase F; rotamase; rotamase F
Homo sapiens (human) : PPIF (peptidylprolyl isomerase F)  HGNC  Alliance
Mus musculus (house mouse) : Ppif (peptidylprolyl isomerase F (cyclophilin F))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppif (peptidylprolyl isomerase F)
Pan paniscus (bonobo/pygmy chimpanzee) : PPIF (peptidylprolyl isomerase F)
Canis lupus familiaris (dog) : PPIF (peptidylprolyl isomerase F)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppif (peptidylprolyl isomerase F)
Sus scrofa (pig) : PPIF (peptidylprolyl isomerase F)
Chlorocebus sabaeus (African green monkey) : PPIF (peptidylprolyl isomerase F)
Heterocephalus glaber (naked mole-rat) : Ppif (peptidylprolyl isomerase F)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: This gene encodes a 177 aa mature peptide that is found in the mitochondrion. It has been labeled 'cyclophilin D'. This same name has also been applied to a different cytoplasmic protein of 370 aa, which is represented by GeneID 361967, Ppid. [12 Mar 2012]
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0161,979,191 - 1,985,912 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl161,979,191 - 1,985,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0161,955,730 - 1,962,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4161,292,835 - 1,299,556 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1161,292,834 - 1,299,555 (+)NCBI
Celera161,234,115 - 1,240,836 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Ppif
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628670
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.