Ppif (peptidylprolyl isomerase F)

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Gene: Ppif (peptidylprolyl isomerase F) Rattus norvegicus

Analyze

Symbol:

Ppif

Name:

peptidylprolyl isomerase F

RGD ID:

628670

Description:

Enables cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in regulation of apoptotic process and regulation of mitochondrial membrane permeability. Located in mitochondrial inner membrane and mitochondrial matrix. Orthologous to human PPIF (peptidylprolyl isomerase F); PARTICIPATES IN toxoplasmosis pathway; INTERACTS WITH 1,1'-azobis(N,N-dimethylformamide); 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cyclophilin D; cyclophilin F; CyP-D; CypD; MGC93084; Peptidyl-prolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase F, mitochondrial; peptidyl-prolyl cis-trans isomerase, mitochondrial; peptidylprolyl isomerase F (cyclophilin F); PPIase; PPIase F; rotamase; rotamase F

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PPIF (peptidylprolyl isomerase F)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ppif (peptidylprolyl isomerase F (cyclophilin F))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ppif (peptidylprolyl isomerase F)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PPIF (peptidylprolyl isomerase F)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PPIF (peptidylprolyl isomerase F)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ppif (peptidylprolyl isomerase F)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PPIF (peptidylprolyl isomerase F)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PPIF (peptidylprolyl isomerase F)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ppif (peptidylprolyl isomerase F)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ZNF625-ZNF20 (ZNF625-ZNF20 readthrough (NMD candidate))	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Ppif (peptidylprolyl isomerase F (cyclophilin F))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PPIF (peptidylprolyl isomerase F)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ppifb (peptidylprolyl isomerase Fb)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CPR1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG7768	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Cyp1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyn-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyn-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyn-3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyn-7	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ppif	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Candidate Gene For:

Arunc2 Arunc1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

NCBI Annotation Information:

Note: This gene encodes a 177 aa mature peptide that is found in the mitochondrion. It has been labeled 'cyclophilin D'. This same name has also been applied to a different cytoplasmic protein of 370 aa, which is represented by GeneID 361967, Ppid. [12 Mar 2012]

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	1,257,197 - 1,263,919 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	1,257,106 - 1,263,913 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	1,263,511 - 1,270,232 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	2,409,364 - 2,416,086 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	1,270,127 - 1,276,849 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	1,979,191 - 1,985,912 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	1,979,191 - 1,985,908 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	1,955,730 - 1,962,451 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	1,292,835 - 1,299,556 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	1,292,834 - 1,299,555 (+)	NCBI
Celera	16	1,234,115 - 1,240,836 (+)	NCBI		Celera
Cytogenetic Map	16	p16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

genetic disease (ISO)

intestinal disease (ISO)

Ulcer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1'-azobis(N,N-dimethylformamide) (EXP,ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

albendazole (ISO)

all-trans-retinoic acid (ISO)

AM-251 (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsenous acid (ISO)

atrazine (EXP)

auranofin (EXP,ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

butanal (ISO)

cadmium atom (ISO)

carbon nanotube (ISO)

celastrol (ISO)

choline (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

curcumin (ISO)

cyclosporin A (EXP,ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

diclofenac (ISO)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (EXP,ISO)

endosulfan (EXP)

Enterolactone (ISO)

epoxiconazole (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

gedunin (ISO)

genistein (EXP)

glycidyl methacrylate (ISO)

hydrogen peroxide (EXP,ISO)

isoprenaline (ISO)

isotretinoin (ISO)

ivermectin (ISO)

kainic acid (ISO)

L-methionine (ISO)

lead diacetate (ISO)

lead(0) (ISO)

levofloxacin (EXP)

LY294002 (ISO)

melphalan (ISO)

menadione (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylparaben (ISO)

N-methyl-4-phenylpyridinium (ISO)

NADP zwitterion (EXP)

NADP(+) (EXP)

nitrofen (EXP)

ochratoxin A (ISO)

oleanolic acid (ISO)

ozone (EXP)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

progesterone (EXP,ISO)

quinolinic acid (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rotenone (EXP)

SB 431542 (ISO)

senecionine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

sulforaphane (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

trichostatin A (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

urethane (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic mitochondrial changes (ISO)

apoptotic process (ISO)

cellular response to arsenic-containing substance (ISO,ISS)

cellular response to calcium ion (ISO,ISS)

cellular response to hydrogen peroxide (IBA,ISO,ISS)

mitochondrial depolarization (ISO)

mitochondrial outer membrane permeabilization involved in programmed cell death (ISO,ISS)

mitochondrion organization (ISO)

muscle structure development (ISO)

necroptotic process (ISO)

negative regulation of apoptotic process (ISO,ISS)

negative regulation of intrinsic apoptotic signaling pathway (ISO,ISS)

negative regulation of oxidative phosphorylation (ISO,ISS)

negative regulation of release of cytochrome c from mitochondria (ISO,ISS)

programmed cell death (ISO)

protein folding (IBA,IEA)

regulation of apoptotic process (IDA)

regulation of mitochondrial membrane permeability (IDA,ISO)

regulation of mitochondrial membrane permeability involved in programmed necrotic cell death (IBA,ISO,ISS)

response to ischemia (ISO,ISS)

response to oxidative stress (ISO)

skeletal muscle fiber differentiation (ISO)

Cellular Component

cytoplasm (IBA)

mitochondrial inner membrane (IDA)

mitochondrial matrix (IDA)

mitochondrial permeability transition pore complex (ISO,ISS)

mitochondrial proton-transporting ATP synthase complex (ISS)

mitochondrion (IBA,ISO)

Molecular Function

cyclosporin A binding (IBA,IDA,ISO)

peptide binding (IDA)

peptidyl-prolyl cis-trans isomerase activity (IBA,IDA,IEA,ISO)

protein binding (IPI,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

toxoplasmosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin.	Connern CP and Halestrap AP, Biochem J 1992 Jun 1;284 ( Pt 2):381-5.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis.	Li Y, etal., Biochem J. 2004 Oct 1;383(Pt 1):101-9.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition.	Woodfield K, etal., Biochem J. 1998 Dec 1;336 ( Pt 2):287-90.

Additional References at PubMed

PMID:12077116	PMID:12477932	PMID:14651853	PMID:15489334	PMID:15800626	PMID:15800627	PMID:16103352	PMID:16551620	PMID:16675492	PMID:16876914	PMID:18350175	PMID:18614015
PMID:18667415	PMID:18684715	PMID:18951528	PMID:19094991	PMID:19228691	PMID:19299432	PMID:19801635	PMID:19832699	PMID:20364102	PMID:20588055	PMID:20651005	PMID:20676357
PMID:21281446	PMID:22726440	PMID:23063677	PMID:26387735	PMID:26975474	PMID:27864141

Genomics

Comparative Map Data

Ppif
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	1,257,197 - 1,263,919 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	1,257,106 - 1,263,913 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	1,263,511 - 1,270,232 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	2,409,364 - 2,416,086 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	1,270,127 - 1,276,849 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	1,979,191 - 1,985,912 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	1,979,191 - 1,985,908 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	1,955,730 - 1,962,451 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	1,292,835 - 1,299,556 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	1,292,834 - 1,299,555 (+)	NCBI
Celera	16	1,234,115 - 1,240,836 (+)	NCBI		Celera
Cytogenetic Map	16	p16	NCBI

PPIF
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	79,347,469 - 79,355,334 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	79,347,469 - 79,355,334 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	81,107,225 - 81,115,090 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	80,777,226 - 80,785,096 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	80,777,225 - 80,785,093	NCBI
Celera	10	74,393,355 - 74,401,225 (+)	NCBI		Celera
Cytogenetic Map	10	q22.3	NCBI
HuRef	10	75,101,849 - 75,109,719 (+)	NCBI		HuRef
CHM1_1	10	81,390,186 - 81,398,056 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	80,216,813 - 80,224,678 (+)	NCBI		T2T-CHM13v2.0

Ppif
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	25,693,998 - 25,700,892 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	25,694,578 - 25,700,892 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	25,693,574 - 25,700,468 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	25,694,154 - 25,700,468 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	26,513,656 - 26,519,954 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	24,527,354 - 24,533,652 (+)	NCBI		MGSCv36	mm8
Celera	14	22,018,432 - 22,024,722 (+)	NCBI		Celera
Cytogenetic Map	14	A3	NCBI
cM Map	14	15.06	NCBI

Ppif
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	13,295,663 - 13,302,175 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	13,295,766 - 13,301,918 (-)	NCBI	ChiLan1.0	ChiLan1.0

PPIF
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	10	91,491,867 - 91,501,079 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	75,860,197 - 75,868,098 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	78,521,996 - 78,530,211 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	78,521,642 - 78,530,202 (+)	Ensembl	panpan1.1		panPan2

PPIF
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	29,074,806 - 29,080,487 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	29,197,719 - 29,204,179 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	29,374,690 - 29,381,134 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	29,374,690 - 29,380,211 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	29,245,431 - 29,251,855 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	29,447,801 - 29,454,224 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	29,801,525 - 29,807,938 (+)	NCBI		UU_Cfam_GSD_1.0

Ppif
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	51,911,849 - 51,918,430 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936521	404,544 - 411,539 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936521	404,574 - 411,381 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPIF
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	81,667,672 - 81,689,495 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	81,674,671 - 81,681,977 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	88,334,121 - 88,341,247 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPIF
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	52,109,865 - 52,117,703 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	52,109,272 - 52,117,483 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	12,454,125 - 12,466,531 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppif
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	12,336,427 - 12,342,687 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	12,336,474 - 12,342,687 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ppif
90 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	113
Count of miRNA genes:	81
Interacting mature miRNAs:	97
Transcripts:	ENSRNOT00000014382
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2325838	Bp347	Blood pressure QTL 347		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	1	3080679	Rat
1357403	Slep4	Serum leptin concentration QTL 4	3.91		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	9639137	Rat
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	22477621	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26727669	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26727669	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	26727669	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	30836262	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	32139025	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33418960	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39533930	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39533930	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		liver copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	39533949	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	1	43534949	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1	44588133	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	44977551	Rat
1549842	Bp248	Blood pressure QTL 248		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	380245	2995463	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	832236	46053497	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat
12903278	Am16	Aortic mass QTL 16		0.019	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	16	832380	2995225	Rat
12903279	Cm115	Cardiac mass QTL 115		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	16	832380	2995225	Rat
12903281	Cm116	Cardiac mass QTL 116		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	16	832380	2995225	Rat
12903952	Cm117	Cardiac mass QTL 117		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	16	832380	2995225	Rat
12903954	Bw186	Body weight QTL 186		0.011	body mass (VT:0001259)	body weight (CMO:0000012)	16	832380	2995225	Rat
2301404	Bp321	Blood pressure QTL 321		0.05	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	832380	2995225	Rat
12903955	Kidm69	Kidney mass QTL 69		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	16	832380	4227609	Rat

Markers in Region

RH128271

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	1,263,583 - 1,263,788 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	1,985,577 - 1,985,781	NCBI	Rnor6.0
Rnor_5.0	16	1,962,116 - 1,962,320	UniSTS	Rnor5.0
RGSC_v3.4	16	1,299,221 - 1,299,425	UniSTS	RGSC3.4
Celera	16	1,240,501 - 1,240,705	UniSTS
Cytogenetic Map	16	p16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	49	39	13	39		3	66	27	30
Low			8	2	6	2	8	8	8	8	11	11	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_172243	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC086977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U68544	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000014382 ⟹ ENSRNOP00000014382

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	1,257,215 - 1,263,913 (+)	Ensembl
Rnor_6.0 Ensembl	16	1,979,191 - 1,985,908 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000106999 ⟹ ENSRNOP00000085863

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	1,257,106 - 1,263,909 (+)	Ensembl

RefSeq Acc Id:

NM_172243 ⟹ NP_758443

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	1,257,197 - 1,263,919 (+)	NCBI
Rnor_6.0	16	1,979,191 - 1,985,912 (+)	NCBI
Rnor_5.0	16	1,955,730 - 1,962,451 (+)	NCBI
RGSC_v3.4	16	1,292,835 - 1,299,556 (+)	RGD
Celera	16	1,234,115 - 1,240,836 (+)	RGD

Sequence:

show sequence

CGCGCGCCCTCGCCCGACCCGTGACAGCGATGCTAGCTCTGCGCTGCGGTCCCCGCCTGCTCGG
TCTGCTCTCCGGCCCGCGCTCCGCGCCGCTCCTCCTCTCCACGACCCGTACCTGCAGCGACGGC
GGAGCCCGAGGCGCGAACTCTTCCTCCCAAAACCCGCTCGTGTACTTGGACGTGGGCGCCGACG
GACAGCCGCTCGGCCGCGTGGTGCTGGAGTTAAAGGCAGATGTCGTGCCAAAGACAGCAGAGAA
CTTCAGAGCCCTGTGCACTGGTGAGAAGGGCTTTGGCTACAAAGGCTCCACCTTCCACAGGGTC
ATCCCAGCCTTCATGTGCCAGGCTGGCGACTTCACCAATCACAATGGCACGGGAGGGAAGTCCA
TCTACGGAAGCCGCTTTCCTGACGAGAACTTCACACTGAAGCACGTGGGACCAGGTGTCCTGTC
CATGGCAAACGCAGGCCCCAACACCAATGGCTCTCAGTTCTTTATCTGCACAATAAAGACAGAC
TGGCTGGATGGCAAGCATGTTGTGTTTGGCCATGTCAAAGAGGGCATGGATGTTGTGAAGAAAA
TAGAATCTTTCGGCTCAAAAAGTGGGAAGACATCTAAGAAGATTGTCATCACAGACTGTGGCCA
GTTGAGCTAAGTCACAGCCAAGGTGCTAGGACAGCAGCAGGCAGCCATGTCTTGGTTCACCCAG
GTACTCCAAAGAACTGTTTGTACCCACTTCTACTGAGTATGAGGAAGGCCACTTGGGCACATGG
TCCCCCACAGGACCAGGCTGCTCTCAACTGTCCATCCTTCCTCAGATCCATTTCTGGGCATCAG
CATGGCCACTGGGCCATGTATCCTTAGCAAGTGTCTCGGTGATTGCCATTGTGTGTGCCTTGGA
CATCGGCAATGCTGACCAGTTAGTCAGAGAAGGCTCCTGCCTTTTTCCTTGACCAGCGGGGACA
GCAGTTGCTATTTAATGTTGTCTTCCTCATTGCAATAATTTAACAAGATCTCATAGGAACAAGC
TACTACACTAACTGCACTGTCTATGTGTGACTGAGTTGGCACAAGCCACAGACACCCCACCACC
ACCACCACCACCACCACCACCACCTCCCCGCCTGGCTTCTGAAACATAACTCAGGGCTCTTGTG
AAAGTCCCACCATCAATGCCTCTCCTTCTGGTCACTGTGAATCCTGCTGGTTGGCTGCTGTGAT
TTTCTGAAAGGAGCCTGTGAAATAGAAGCAGCTGGACCTGGGGACAGACCTGTGAGCCAGGCCT
GTCTGCTCAATGTGAATTCCTGTGTTGAAAACTTACAGAAACTGCCTGAATTCATGCTCTCCTC
AAGAGGGAAGTGTTTTCTGGTAGGCTTTGCTTTTTCTGTATGTTAAATCAATCAATCAATGATA
TATATGTAGAAGATTTCTGAACAGTCCTCTGTGTTCATCTCAAATGTGATAAATAAATCCTATT
TTCTATAAAAAAAAAAAAAAAAAAAC

hide sequence

Protein Sequences


Protein RefSeqs	NP_758443	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB08453	(Get FASTA)	NCBI Sequence Viewer
	AAH86977	(Get FASTA)	NCBI Sequence Viewer
	EDL75095	(Get FASTA)	NCBI Sequence Viewer
	EDL75096	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000014382.4
	ENSRNOP00000085863
GenBank Protein	P29117	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_758443 ⟸ NM_172243
- Peptide Label:	precursor
- UniProtKB:	P29117 (UniProtKB/Swiss-Prot), A6KMH2 (UniProtKB/TrEMBL), A0A8L2Q6S2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLALRCGPRLLGLLSGPRSAPLLLSTTRTCSDGGARGANSSSQNPLVYLDVGADGQPLGRVVLE LKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPAFMCQAGDFTNHNGTGGKSIYGSRFPDEN FTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKHVVFGHVKEGMDVVKKIESFGSKSGK TSKKIVITDCGQLS hide sequence

RefSeq Acc Id:

ENSRNOP00000014382 ⟸ ENSRNOT00000014382

RefSeq Acc Id:

ENSRNOP00000085863 ⟸ ENSRNOT00000106999

Protein Domains

PPIase cyclophilin-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P29117-F1-model_v2	AlphaFold	P29117	1-206	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699891

Promoter ID:

EPDNEW_R10415

Type:

initiation region

Name:

Ppif_1

Description:

peptidylprolyl isomerase F

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	1,979,145 - 1,979,205	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628670	AgrOrtholog
BioCyc Gene	G2FUF-12271	BioCyc
Ensembl Genes	ENSRNOG00000010558	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000014382.7	UniProtKB/TrEMBL
	ENSRNOT00000106999	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	2.40.100.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7193156	IMAGE-MGC_LOAD
InterPro	Cyclophilin-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cyclophilin-type_PPIase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cyclophilin-type_PPIase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:282819	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93084	IMAGE-MGC_LOAD
NCBI Gene	282819	ENTREZGENE
PANTHER	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Pro_isomerase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ppif	PhenoGen
PRINTS	CSAPPISMRASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	CSA_PPIASE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CSA_PPIASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010558	RatGTEx
Superfamily-SCOP	SSF50891	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2Q6S2	ENTREZGENE, UniProtKB/TrEMBL
	A6KMH2	ENTREZGENE, UniProtKB/TrEMBL
	A6KMH3_RAT	UniProtKB/TrEMBL
	P29117	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-04-23	Ppif	peptidylprolyl isomerase F	Ppif	peptidylprolyl isomerase F (cyclophilin F)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Ppif	peptidylprolyl isomerase F (cyclophilin F)		peptidylprolyl isomerase F	Name updated	1299863	APPROVED
2003-02-27	Ppif	peptidylprolyl isomerase F			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)