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Gene: Ppif (peptidylprolyl isomerase F) Rattus norvegicus
Symbol: Ppif
Name: peptidylprolyl isomerase F
Description: Exhibits cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in regulation of apoptotic process and regulation of mitochondrial membrane permeability. Localizes to the mitochondrial inner membrane and mitochondrial matrix. Predicted to colocalize with the mitochondrial proton-transporting ATP synthase complex. Orthologous to human PPIF (peptidylprolyl isomerase F); PARTICIPATES IN toxoplasmosis pathway; INTERACTS WITH 1,1'-azobis(N,N-dimethylformamide); 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
Also known as: cyclophilin D; cyclophilin F; CyP-D; CypD; MGC93084; Peptidyl-prolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase F, mitochondrial; peptidyl-prolyl cis-trans isomerase, mitochondrial; peptidylprolyl isomerase F (cyclophilin F); PPIase; PPIase F; rotamase; rotamase F
Homo sapiens (human) : PPIF (peptidylprolyl isomerase F)  HGNC  Alliance
Mus musculus (house mouse) : Ppif (peptidylprolyl isomerase F (cyclophilin F))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppif (peptidylprolyl isomerase F)
Pan paniscus (bonobo/pygmy chimpanzee) : PPIF (peptidylprolyl isomerase F)
Canis lupus familiaris (dog) : PPIF (peptidylprolyl isomerase F)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppif (peptidylprolyl isomerase F)
Sus scrofa (pig) : PPIF (peptidylprolyl isomerase F)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: This gene encodes a 177 aa mature peptide that is found in the mitochondrion. It has been labeled 'cyclophilin D'. This same name has also been applied to a different cytoplasmic protein of 370 aa, which is represented by GeneID 361967, Ppid. [12 Mar 2012]
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0161,979,191 - 1,985,912 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0161,955,730 - 1,962,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4161,292,835 - 1,299,556 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1161,292,834 - 1,299,555 (+)NCBI
Celera161,234,115 - 1,240,836 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Ppif
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628670
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.