Ppif (peptidylprolyl isomerase F) - Rat Genome Database

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Gene: Ppif (peptidylprolyl isomerase F) Rattus norvegicus
Analyze
Symbol: Ppif
Name: peptidylprolyl isomerase F
RGD ID: 628670
Description: Enables cyclosporin A binding activity; peptide binding activity; and peptidyl-prolyl cis-trans isomerase activity. Involved in regulation of apoptotic process and regulation of mitochondrial membrane permeability. Located in mitochondrial inner membrane. Is active in mitochondrial matrix. Orthologous to human PPIF (peptidylprolyl isomerase F); PARTICIPATES IN toxoplasmosis pathway; INTERACTS WITH 1,1'-azobis(N,N-dimethylformamide); 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cyclophilin D; cyclophilin F; CyP-D; CypD; MGC93084; Peptidyl-prolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase F, mitochondrial; peptidyl-prolyl cis-trans isomerase, mitochondrial; peptidylprolyl isomerase F (cyclophilin F); PPIase; PPIase F; rotamase; rotamase F
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Arunc2 Arunc1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: This gene encodes a 177 aa mature peptide that is found in the mitochondrion. It has been labeled 'cyclophilin D'. This same name has also been applied to a different cytoplasmic protein of 370 aa, which is represented by GeneID 361967, Ppid. [12 Mar 2012]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8161,264,001 - 1,270,722 (+)NCBIGRCr8
mRatBN7.2161,257,197 - 1,263,919 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl161,257,106 - 1,263,913 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx161,263,511 - 1,270,232 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0162,409,364 - 2,416,086 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0161,270,127 - 1,276,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0161,979,191 - 1,985,912 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl161,979,191 - 1,985,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0161,955,730 - 1,962,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4161,292,835 - 1,299,556 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1161,292,834 - 1,299,555 (+)NCBI
Celera161,234,115 - 1,240,836 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)
intestinal disease  (ISO)
Ulcer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
amlodipine  (EXP,ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
auranofin  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
choline  (ISO)
cilnidipine  (EXP,ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gedunin  (ISO)
genistein  (EXP)
glycidyl methacrylate  (ISO)
hydrogen peroxide  (EXP,ISO)
iohexol  (EXP,ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
levofloxacin  (EXP)
LY294002  (ISO)
melphalan  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nifedipine  (EXP,ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
quinolinic acid  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin. Connern CP and Halestrap AP, Biochem J 1992 Jun 1;284 ( Pt 2):381-5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1. Li W, etal., J Pharmacol Exp Ther. 2011 Jan;336(1):87-94. doi: 10.1124/jpet.110.173195. Epub 2010 Sep 30.
4. Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis. Li Y, etal., Biochem J. 2004 Oct 1;383(Pt 1):101-9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition. Woodfield K, etal., Biochem J. 1998 Dec 1;336 ( Pt 2):287-90.
Additional References at PubMed
PMID:12077116   PMID:12477932   PMID:14651853   PMID:15489334   PMID:15800626   PMID:15800627   PMID:16103352   PMID:16551620   PMID:16675492   PMID:16876914   PMID:18350175   PMID:18614015  
PMID:18667415   PMID:18684715   PMID:18951528   PMID:19094991   PMID:19228691   PMID:19299432   PMID:19801635   PMID:19832699   PMID:20364102   PMID:20588055   PMID:20651005   PMID:20676357  
PMID:21281446   PMID:22726440   PMID:23063677   PMID:26387735   PMID:26975474   PMID:27864141  


Genomics

Comparative Map Data
Ppif
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8161,264,001 - 1,270,722 (+)NCBIGRCr8
mRatBN7.2161,257,197 - 1,263,919 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl161,257,106 - 1,263,913 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx161,263,511 - 1,270,232 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0162,409,364 - 2,416,086 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0161,270,127 - 1,276,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0161,979,191 - 1,985,912 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl161,979,191 - 1,985,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0161,955,730 - 1,962,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4161,292,835 - 1,299,556 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1161,292,834 - 1,299,555 (+)NCBI
Celera161,234,115 - 1,240,836 (+)NCBICelera
Cytogenetic Map16p16NCBI
PPIF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381079,347,469 - 79,355,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1079,347,469 - 79,355,334 (+)EnsemblGRCh38hg38GRCh38
GRCh371081,107,225 - 81,115,090 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361080,777,226 - 80,785,096 (+)NCBINCBI36Build 36hg18NCBI36
Build 341080,777,225 - 80,785,093NCBI
Celera1074,393,355 - 74,401,225 (+)NCBICelera
Cytogenetic Map10q22.3NCBI
HuRef1075,101,849 - 75,109,719 (+)NCBIHuRef
CHM1_11081,390,186 - 81,398,056 (+)NCBICHM1_1
T2T-CHM13v2.01080,216,813 - 80,224,678 (+)NCBIT2T-CHM13v2.0
Ppif
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391425,693,998 - 25,700,892 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1425,694,578 - 25,700,892 (+)EnsemblGRCm39 Ensembl
GRCm381425,693,574 - 25,700,468 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1425,694,154 - 25,700,468 (+)EnsemblGRCm38mm10GRCm38
MGSCv371426,513,656 - 26,519,954 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361424,527,354 - 24,533,652 (+)NCBIMGSCv36mm8
Celera1422,018,432 - 22,024,722 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1415.06NCBI
Ppif
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543713,295,663 - 13,302,175 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543713,295,766 - 13,301,918 (-)NCBIChiLan1.0ChiLan1.0
PPIF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2891,486,543 - 91,496,372 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11091,491,867 - 91,501,079 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01075,860,197 - 75,868,098 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11078,521,996 - 78,530,211 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1078,521,642 - 78,530,202 (+)Ensemblpanpan1.1panPan2
PPIF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1429,074,806 - 29,080,487 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha429,197,719 - 29,204,179 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0429,374,690 - 29,381,134 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl429,374,690 - 29,380,211 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1429,245,431 - 29,251,855 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0429,447,801 - 29,454,224 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0429,801,525 - 29,807,938 (+)NCBIUU_Cfam_GSD_1.0
Ppif
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721351,911,849 - 51,918,430 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936521404,544 - 411,539 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936521404,574 - 411,381 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPIF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1481,667,672 - 81,689,495 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11481,674,671 - 81,681,977 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21488,334,121 - 88,341,247 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPIF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1952,109,865 - 52,117,703 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl952,109,272 - 52,117,483 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604812,454,125 - 12,466,531 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppif
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475412,336,427 - 12,342,687 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475412,336,474 - 12,342,687 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppif
92 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:81
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000014382
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)163802452995463Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
12903952Cm117Cardiac mass QTL 1170.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)168323802995225Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
12903954Bw186Body weight QTL 1860.011body mass (VT:0001259)body weight (CMO:0000012)168323802995225Rat
12903955Kidm69Kidney mass QTL 690.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)168323804227609Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
12903278Am16Aortic mass QTL 160.019aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)168323802995225Rat
12903279Cm115Cardiac mass QTL 1150.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)168323802995225Rat
2325838Bp347Blood pressure QTL 3470.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1613080679Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
12903281Cm116Cardiac mass QTL 1160.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)168323802995225Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301404Bp321Blood pressure QTL 3210.05arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)168323802995225Rat

Markers in Region
RH128271  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2161,263,583 - 1,263,788 (+)MAPPERmRatBN7.2
Rnor_6.0161,985,577 - 1,985,781NCBIRnor6.0
Rnor_5.0161,962,116 - 1,962,320UniSTSRnor5.0
RGSC_v3.4161,299,221 - 1,299,425UniSTSRGSC3.4
Celera161,240,501 - 1,240,705UniSTS
Cytogenetic Map16p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000014382   ⟹   ENSRNOP00000014382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl161,257,215 - 1,263,913 (+)Ensembl
Rnor_6.0 Ensembl161,979,191 - 1,985,908 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106999   ⟹   ENSRNOP00000085863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl161,257,106 - 1,263,909 (+)Ensembl
RefSeq Acc Id: NM_172243   ⟹   NP_758443
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8161,264,001 - 1,270,722 (+)NCBI
mRatBN7.2161,257,197 - 1,263,919 (+)NCBI
Rnor_6.0161,979,191 - 1,985,912 (+)NCBI
Rnor_5.0161,955,730 - 1,962,451 (+)NCBI
RGSC_v3.4161,292,835 - 1,299,556 (+)RGD
Celera161,234,115 - 1,240,836 (+)RGD
Sequence:
RefSeq Acc Id: NP_758443   ⟸   NM_172243
- Peptide Label: precursor
- UniProtKB: P29117 (UniProtKB/Swiss-Prot),   A6KMH2 (UniProtKB/TrEMBL),   A0A8L2Q6S2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014382   ⟸   ENSRNOT00000014382
Ensembl Acc Id: ENSRNOP00000085863   ⟸   ENSRNOT00000106999
Protein Domains
PPIase cyclophilin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29117-F1-model_v2 AlphaFold P29117 1-206 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699891
Promoter ID:EPDNEW_R10415
Type:initiation region
Name:Ppif_1
Description:peptidylprolyl isomerase F
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0161,979,145 - 1,979,205EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628670 AgrOrtholog
BioCyc Gene G2FUF-12271 BioCyc
Ensembl Genes ENSRNOG00000010558 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055021582 UniProtKB/Swiss-Prot
  ENSRNOG00060013231 UniProtKB/Swiss-Prot
  ENSRNOG00065015119 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014382.7 UniProtKB/TrEMBL
  ENSRNOT00000106999.1 UniProtKB/Swiss-Prot
  ENSRNOT00055036906 UniProtKB/Swiss-Prot
  ENSRNOT00060022551 UniProtKB/Swiss-Prot
  ENSRNOT00065025031 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193156 IMAGE-MGC_LOAD
InterPro Cyclophilin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:282819 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93084 IMAGE-MGC_LOAD
NCBI Gene 282819 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pro_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppif PhenoGen
PRINTS CSAPPISMRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CSA_PPIASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CSA_PPIASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010558 RatGTEx
  ENSRNOG00055021582 RatGTEx
  ENSRNOG00060013231 RatGTEx
  ENSRNOG00065015119 RatGTEx
Superfamily-SCOP SSF50891 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q6S2 ENTREZGENE, UniProtKB/TrEMBL
  A6KMH2 ENTREZGENE, UniProtKB/TrEMBL
  A6KMH3_RAT UniProtKB/TrEMBL
  P29117 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Ppif  peptidylprolyl isomerase F  Ppif  peptidylprolyl isomerase F (cyclophilin F)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ppif  peptidylprolyl isomerase F (cyclophilin F)    peptidylprolyl isomerase F  Name updated 1299863 APPROVED
2003-02-27 Ppif  peptidylprolyl isomerase F      Symbol and Name status set to provisional 70820 PROVISIONAL