APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) - Rat Genome Database

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Gene: APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) Pan paniscus
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Symbol: APPL1
Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
RGD ID: 11712661
Description: ENCODES a protein that exhibits beta-tubulin binding (inferred); identical protein binding (inferred); phosphatidylinositol binding (inferred); INVOLVED IN adiponectin-activated signaling pathway (inferred); cellular response to hepatocyte growth factor stimulus (inferred); insulin receptor signaling pathway (inferred); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); maturity-onset diabetes of the young type 14 (ortholog); Pyruvate Dehydrogenase E1-Beta Deficiency (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog); presynapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DCC-interacting protein 13-alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2257,196,344 - 57,241,732 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1357,201,137 - 57,246,504 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0357,161,299 - 57,206,672 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1358,370,424 - 58,415,258 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl358,370,430 - 58,415,258 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
APPL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2257,196,344 - 57,241,732 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1357,201,137 - 57,246,504 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0357,161,299 - 57,206,672 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1358,370,424 - 58,415,258 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl358,370,430 - 58,415,258 (+)Ensemblpanpan1.1panPan2
APPL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38357,227,729 - 57,273,471 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl357,227,726 - 57,278,105 (+)EnsemblGRCh38hg38GRCh38
GRCh37357,261,757 - 57,307,499 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36357,236,805 - 57,282,539 (+)NCBINCBI36Build 36hg18NCBI36
Celera357,227,340 - 57,273,073 (+)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef357,310,967 - 57,356,664 (+)NCBIHuRef
CHM1_1357,211,913 - 57,257,646 (+)NCBICHM1_1
T2T-CHM13v2.0357,267,997 - 57,313,740 (+)NCBIT2T-CHM13v2.0
Appl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391426,640,943 - 26,692,567 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1426,640,945 - 26,693,189 (-)EnsemblGRCm39 Ensembl
GRCm381426,918,986 - 26,970,611 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1426,918,988 - 26,971,232 (-)EnsemblGRCm38mm10GRCm38
MGSCv371427,732,174 - 27,783,737 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361425,745,872 - 25,797,435 (-)NCBIMGSCv36mm8
Celera1423,158,676 - 23,210,368 (-)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1416.09NCBI
Appl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8162,125,234 - 2,173,457 (-)NCBIGRCr8
mRatBN7.2162,118,503 - 2,166,741 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl162,121,255 - 2,166,692 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx162,125,142 - 2,173,305 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0163,270,829 - 3,318,993 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0162,131,417 - 2,179,844 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0162,560,103 - 2,602,035 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl162,563,520 - 2,602,103 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0162,534,851 - 2,581,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4162,180,613 - 2,227,905 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1162,179,191 - 2,228,173 (-)NCBI
Celera162,089,133 - 2,134,528 (-)NCBICelera
Cytogenetic Map16p16NCBI
Appl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554306,986,759 - 7,018,938 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554306,986,977 - 7,018,938 (+)NCBIChiLan1.0ChiLan1.0
APPL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12033,123,577 - 33,166,831 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2033,130,723 - 33,166,792 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2033,051,161 - 33,094,218 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02033,395,990 - 33,439,031 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2033,402,695 - 33,439,040 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,845,010 - 32,887,864 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02033,203,498 - 33,246,471 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02033,374,797 - 33,418,067 (-)NCBIUU_Cfam_GSD_1.0
Appl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118174,441,878 - 174,476,919 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364737,579,780 - 7,611,923 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364737,580,495 - 7,647,471 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APPL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1339,089,077 - 39,129,781 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11339,089,157 - 39,124,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
APPL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12218,546,694 - 18,591,239 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2218,546,751 - 18,589,552 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041148,278,109 - 148,324,433 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Appl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462482233,880 - 74,308 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462482231,175 - 74,252 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000052624   ⟹   ENSPPAP00000029773
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl358,370,430 - 58,415,258 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000052657   ⟹   ENSPPAP00000029806
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl358,370,476 - 58,411,490 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000052659   ⟹   ENSPPAP00000029808
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl358,370,476 - 58,411,490 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000052671   ⟹   ENSPPAP00000029820
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl358,379,743 - 58,411,490 (+)Ensembl
RefSeq Acc Id: XM_003818708   ⟹   XP_003818756
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2257,196,344 - 57,241,732 (+)NCBI
NHGRI_mPanPan1357,201,137 - 57,246,504 (+)NCBI
Mhudiblu_PPA_v0357,161,299 - 57,206,672 (+)NCBI
PanPan1.1358,370,430 - 58,415,258 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014344253   ⟹   XP_014199739
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2257,196,503 - 57,241,732 (+)NCBI
NHGRI_mPanPan1357,201,223 - 57,246,504 (+)NCBI
Mhudiblu_PPA_v0357,161,314 - 57,205,808 (+)NCBI
PanPan1.1358,370,424 - 58,415,258 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003818756 (Get FASTA)   NCBI Sequence Viewer  
  XP_014199739 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000029773
  ENSPPAP00000029773.1
  ENSPPAP00000029806.1
  ENSPPAP00000029808.1
  ENSPPAP00000029820.1
RefSeq Acc Id: XP_014199739   ⟸   XM_014344253
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BTA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003818756   ⟸   XM_003818708
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BK75 (UniProtKB/TrEMBL),   A0A2R9BTA2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000029808   ⟸   ENSPPAT00000052659
Ensembl Acc Id: ENSPPAP00000029820   ⟸   ENSPPAT00000052671
Ensembl Acc Id: ENSPPAP00000029773   ⟸   ENSPPAT00000052624
Ensembl Acc Id: ENSPPAP00000029806   ⟸   ENSPPAT00000052657
Protein Domains
PH   PID


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037799 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000052624.1 UniProtKB/TrEMBL
  ENSPPAT00000052657.1 UniProtKB/TrEMBL
  ENSPPAT00000052659.1 UniProtKB/TrEMBL
  ENSPPAT00000052671.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/TrEMBL
  APPL1_BAR UniProtKB/TrEMBL
  BAR_dom UniProtKB/TrEMBL
  DP13A/B UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PH_DP13A/B UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
  PTB_APPL UniProtKB/TrEMBL
KEGG Report pps:100995535 UniProtKB/TrEMBL
NCBI Gene APPL1 ENTREZGENE
PANTHER ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2 UniProtKB/TrEMBL
  DCC-INTERACTING PROTEIN 13-ALPHA UniProtKB/TrEMBL
Pfam BAR_3 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
SMART PTB UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF103657 UniProtKB/TrEMBL
UniProt A0A2R9BJH1_PANPA UniProtKB/TrEMBL
  A0A2R9BK75 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BKA3_PANPA UniProtKB/TrEMBL
  A0A2R9BTA2 ENTREZGENE, UniProtKB/TrEMBL