APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) - Rat Genome Database
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Gene: APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) Pan paniscus
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Symbol: APPL1
Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
RGD ID: 11712661
Description: ENCODES a protein that exhibits beta-tubulin binding (ortholog); identical protein binding (ortholog); phosphatidylinositol binding (ortholog); INVOLVED IN adiponectin-activated signaling pathway (ortholog); cellular response to hepatocyte growth factor stimulus (ortholog); insulin receptor signaling pathway (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); maturity-onset diabetes of the young type 14 (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic vesicle (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: DCC-interacting protein 13-alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1358,370,424 - 58,415,258 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl358,370,430 - 58,415,258 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0357,161,299 - 57,206,672 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Genomics

Comparative Map Data
APPL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1358,370,424 - 58,415,258 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl358,370,430 - 58,415,258 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0357,161,299 - 57,206,672 (+)NCBIMhudiblu_PPA_v0panPan3
APPL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl357,227,726 - 57,278,105 (+)EnsemblGRCh38hg38GRCh38
GRCh38357,227,729 - 57,273,471 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37357,261,765 - 57,307,499 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36357,236,805 - 57,282,539 (+)NCBINCBI36hg18NCBI36
Celera357,227,340 - 57,273,073 (+)NCBI
Cytogenetic Map3p14.3NCBI
HuRef357,310,967 - 57,356,664 (+)NCBIHuRef
CHM1_1357,211,913 - 57,257,646 (+)NCBICHM1_1
Appl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391426,640,943 - 26,692,567 (-)NCBIGRCm39mm39
GRCm381426,918,986 - 26,970,611 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1426,918,988 - 26,971,232 (-)EnsemblGRCm38mm10GRCm38
MGSCv371427,732,174 - 27,783,737 (-)NCBIGRCm37mm9NCBIm37
MGSCv361425,745,872 - 25,797,435 (-)NCBImm8
Celera1423,158,676 - 23,210,368 (-)NCBICelera
Cytogenetic Map14A3NCBI
Appl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0162,560,103 - 2,602,035 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl162,563,520 - 2,602,103 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0162,534,851 - 2,581,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4162,180,613 - 2,227,905 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1162,179,191 - 2,228,173 (-)NCBI
Celera162,089,133 - 2,134,528 (-)NCBICelera
Cytogenetic Map16p16NCBI
Appl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554306,986,759 - 7,018,938 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554306,986,977 - 7,018,938 (+)NCBIChiLan1.0ChiLan1.0
APPL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2033,130,723 - 33,166,792 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12033,123,577 - 33,166,831 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Appl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364737,580,495 - 7,647,471 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APPL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1339,089,045 - 39,129,781 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11339,089,157 - 39,124,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
APPL1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2218,546,751 - 18,589,552 (+)Ensembl
ChlSab1.12218,546,694 - 18,591,239 (+)NCBI
Appl1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462482231,175 - 74,252 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000052624   ⟹   ENSPPAP00000029773
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl358,370,430 - 58,415,258 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052657   ⟹   ENSPPAP00000029806
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl358,370,476 - 58,411,490 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052659   ⟹   ENSPPAP00000029808
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl358,370,476 - 58,411,490 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052671   ⟹   ENSPPAP00000029820
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl358,379,743 - 58,411,490 (+)Ensembl
RefSeq Acc Id: XM_003818708   ⟹   XP_003818756
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1358,370,430 - 58,415,258 (+)NCBI
Mhudiblu_PPA_v0357,161,299 - 57,206,672 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014344253   ⟹   XP_014199739
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1358,370,424 - 58,415,258 (+)NCBI
Mhudiblu_PPA_v0357,161,314 - 57,205,808 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034956709   ⟹   XP_034812600
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0357,161,308 - 57,205,808 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003818756 (Get FASTA)   NCBI Sequence Viewer  
  XP_014199739 (Get FASTA)   NCBI Sequence Viewer  
  XP_034812600 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_014199739   ⟸   XM_014344253
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_003818756   ⟸   XM_003818708
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034812600   ⟸   XM_034956709
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000029808   ⟸   ENSPPAT00000052659
RefSeq Acc Id: ENSPPAP00000029820   ⟸   ENSPPAT00000052671
RefSeq Acc Id: ENSPPAP00000029773   ⟸   ENSPPAT00000052624
RefSeq Acc Id: ENSPPAP00000029806   ⟸   ENSPPAT00000052657
Protein Domains
PH   PID


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037799 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000029773 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000029806 UniProtKB/TrEMBL
  ENSPPAP00000029808 UniProtKB/TrEMBL
  ENSPPAP00000029820 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000052624 UniProtKB/TrEMBL
  ENSPPAT00000052657 UniProtKB/TrEMBL
  ENSPPAT00000052659 UniProtKB/TrEMBL
  ENSPPAT00000052671 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/TrEMBL
  APPL1_BAR UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
KEGG Report pps:100995535 UniProtKB/TrEMBL
NCBI Gene APPL1 ENTREZGENE
Pfam PF00169 UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
SMART PTB UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/TrEMBL
UniProt A0A2R9BJH1_PANPA UniProtKB/TrEMBL
  A0A2R9BK75_PANPA UniProtKB/TrEMBL
  A0A2R9BKA3_PANPA UniProtKB/TrEMBL
  A0A2R9BTA2_PANPA UniProtKB/TrEMBL