Dkk1 (dickkopf WNT signaling pathway inhibitor 1) - Rat Genome Database

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Gene: Dkk1 (dickkopf WNT signaling pathway inhibitor 1) Rattus norvegicus
Symbol: Dkk1
Name: dickkopf WNT signaling pathway inhibitor 1
RGD ID: 1307313
Description: Predicted to enable co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in negative regulation of ossification. Located in extracellular space. Used to study visual epilepsy. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
Previously known as: dickkopf 1 homolog; dickkopf 1 homolog (Xenopus laevis); dickkopf homolog 1; dickkopf homolog 1 (Xenopus laevis); dickkopf-like protein 1; dickkopf-related protein 1; LOC293897; NEWGENE_1307313
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81237,794,969 - 237,798,650 (-)NCBIGRCr8
mRatBN7.21228,381,521 - 228,385,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1228,381,521 - 228,385,202 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,756,597 - 236,760,287 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,686,298 - 243,689,990 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,516,916 - 236,520,591 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,952,896 - 248,956,579 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,954,244 - 248,956,446 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,895,738 - 248,898,607 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01256,133,073 - 256,136,756 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,392,743 - 234,396,426 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1225,519,220 - 225,522,904 (-)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,4-benzoquinone  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ampicillin  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
belinostat  (ISO)
benzamides  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
buserelin  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chitosan  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clomiphene  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenziodolium  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethosuximide  (EXP,ISO)
flavonoids  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
Icaritin  (ISO)
iron dichloride  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
letrozole  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
molibresib  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naringin  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
niclosamide  (ISO)
p-anisidine  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propan-2-ol  (ISO)
pyrvinium  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
sulforaphane  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
wortmannin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
canonical Wnt signaling pathway  (ISO)
cell morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
endoderm development  (ISO)
endoderm formation  (ISO)
face morphogenesis  (ISO)
forebrain development  (ISO)
hair follicle development  (ISO)
head morphogenesis  (ISO)
heart induction  (ISO)
learning or memory  (ISO)
limb development  (ISO)
mesoderm formation  (ISO)
motor learning  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of canonical Wnt signaling pathway  (IBA,ISO)
negative regulation of cardiac muscle cell differentiation  (ISO)
negative regulation of mesodermal cell fate specification  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of ossification  (IMP,ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of presynapse assembly  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of Wnt signaling pathway  (ISO)
negative regulation of Wnt-Frizzled-LRP5/6 complex assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of midbrain dopaminergic neuron differentiation  (ISO)
regulation of endodermal cell fate specification  (ISO)
regulation of receptor internalization  (ISO)
regulation of synapse organization  (ISO)
regulation of synaptic transmission, glutamatergic  (ISO)
regulation of Wnt signaling pathway  (ISO)
response to retinoic acid  (ISO)
Wnt signaling pathway  (ISO)
Wnt signaling pathway involved in somitogenesis  (ISO)

Cellular Component
extracellular space  (IBA,IDA,ISO)
plasma membrane  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy. Busceti CL, etal., Epilepsia. 2007 Apr;48(4):694-705.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Insulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation. Hie M, etal., Int J Mol Med. 2011 Sep;28(3):455-62. doi: 10.3892/ijmm.2011.697. Epub 2011 May 11.
5. Clusterin regulates ß-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Killick R, etal., Mol Psychiatry. 2014 Jan;19(1):88-98. doi: 10.1038/mp.2012.163. Epub 2012 Nov 20.
6. Wnt signalling and its impact on development and cancer. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
7. Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury. Li X, etal., J Bone Miner Res. 2011 Nov;26(11):2610-21. doi: 10.1002/jbmr.472.
8. Dickkopf-1 promotes hyperglycemia-induced accumulation of mesangial matrix and renal dysfunction. Lin CL, etal., J Am Soc Nephrol. 2010 Jan;21(1):124-35. Epub 2009 Dec 17.
9. A case-control study of the association between tooth-development gene polymorphisms and non-syndromic hypodontia in the Chinese Han population. Liu H, etal., Eur J Oral Sci. 2012 Oct;120(5):378-85. doi: 10.1111/j.1600-0722.2012.00986.x. Epub 2012 Aug 18.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Function and biological roles of the Dickkopf family of Wnt modulators. Niehrs C Oncogene. 2006 Dec 4;25(57):7469-81.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees. Weng LH, etal., Arthritis Rheum. 2010 May;62(5):1393-402.
16. Dynamic expression of DKK1 protein in the process whereby Epimedium-derived flavonoids up-regulate osteogenic and down-regulate adipogenic differentiation of bone marrow stromal cells in ovariectomized rats. Xu YX, etal., Orthop Surg. 2011 May;3(2):119-26. doi: 10.1111/j.1757-7861.2011.00129.x.
Additional References at PubMed
PMID:11433302   PMID:11448771   PMID:11742004   PMID:12857724   PMID:15020244   PMID:15143170   PMID:15242796   PMID:16126904   PMID:16263759   PMID:16682203   PMID:16753024   PMID:16805831  
PMID:17027228   PMID:17055793   PMID:17064353   PMID:17127040   PMID:17128274   PMID:17360443   PMID:17699607   PMID:17804636   PMID:17804805   PMID:18044981   PMID:18166153   PMID:18174290  
PMID:18257070   PMID:18297060   PMID:18403408   PMID:18462699   PMID:18505732   PMID:18505822   PMID:18716201   PMID:19850024   PMID:19850029   PMID:20039315   PMID:20093360   PMID:20160075  
PMID:20383322   PMID:20559569   PMID:20723538   PMID:21347250   PMID:21540552   PMID:22133691   PMID:22399772   PMID:22615920   PMID:22902902   PMID:23152495   PMID:23164620   PMID:25318560  
PMID:26206087   PMID:26351298   PMID:27277008   PMID:27353797   PMID:28332284   PMID:28807065   PMID:29472591   PMID:29643768   PMID:33172955   PMID:35691117   PMID:37108841   PMID:37859694  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81237,794,969 - 237,798,650 (-)NCBIGRCr8
mRatBN7.21228,381,521 - 228,385,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1228,381,521 - 228,385,202 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,756,597 - 236,760,287 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,686,298 - 243,689,990 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,516,916 - 236,520,591 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,952,896 - 248,956,579 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,954,244 - 248,956,446 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,895,738 - 248,898,607 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01256,133,073 - 256,136,756 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,392,743 - 234,396,426 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1225,519,220 - 225,522,904 (-)NCBICelera
Cytogenetic Map1q52NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381052,314,281 - 52,317,657 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1052,314,281 - 52,318,042 (+)EnsemblGRCh38hg38GRCh38
GRCh371054,074,041 - 54,077,417 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361053,744,047 - 53,747,423 (+)NCBINCBI36Build 36hg18NCBI36
Build 341053,744,083 - 53,747,149NCBI
Celera1047,337,087 - 47,340,463 (+)NCBICelera
Cytogenetic Map10q21.1NCBI
HuRef1048,051,883 - 48,055,259 (+)NCBIHuRef
CHM1_11054,355,855 - 54,359,231 (+)NCBICHM1_1
T2T-CHM13v2.01053,160,859 - 53,164,235 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391930,523,276 - 30,526,896 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,523,263 - 30,527,065 (-)EnsemblGRCm39 Ensembl
GRCm381930,545,876 - 30,549,496 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,545,863 - 30,549,665 (-)EnsemblGRCm38mm10GRCm38
MGSCv371930,620,366 - 30,623,986 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,611,873 - 30,615,493 (-)NCBIMGSCv36mm8
Celera1931,330,434 - 31,334,040 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1925.16NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_0049554257,353,964 - 7,357,599 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2864,610,223 - 64,613,823 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11064,615,691 - 64,619,145 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01048,950,704 - 48,953,815 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11051,084,963 - 51,088,424 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1051,084,027 - 51,089,776 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12635,697,428 - 35,701,596 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2635,697,618 - 35,701,496 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2635,582,535 - 35,586,059 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02637,227,528 - 37,231,046 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2637,228,230 - 37,231,494 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12635,133,162 - 35,136,678 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02634,718,578 - 34,722,096 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02635,960,801 - 35,964,325 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440721375,285,796 - 75,288,505 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936787306,941 - 310,166 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936787307,290 - 309,963 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1497,487,226 - 97,490,288 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11497,487,854 - 97,490,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214106,115,155 - 106,117,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1978,836,803 - 78,840,158 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl978,835,162 - 78,840,146 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604839,790,339 - 39,794,538 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462479111,313,142 - 11,315,982 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479111,313,139 - 11,316,998 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Dkk1
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:81
Interacting mature miRNAs:85
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1207702246228581766Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,387,043 - 228,387,210 (+)MAPPERmRatBN7.2
Rnor_6.01248,958,421 - 248,958,587NCBIRnor6.0
Rnor_6.01248,900,417 - 248,900,583NCBIRnor6.0
Rnor_5.01256,197,449 - 256,197,615UniSTSRnor5.0
Rnor_5.01256,138,598 - 256,138,764UniSTSRnor5.0
RGSC_v3.41234,398,268 - 234,398,434UniSTSRGSC3.4
Celera1225,524,746 - 225,524,912UniSTS
RH 3.4 Map11619.8UniSTS
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,383,046 - 228,383,108 (+)MAPPERmRatBN7.2
Rnor_6.01248,954,424 - 248,954,485NCBIRnor6.0
Rnor_6.01248,896,420 - 248,896,481NCBIRnor6.0
Rnor_5.01256,134,601 - 256,134,662UniSTSRnor5.0
Rnor_5.01256,193,452 - 256,193,513UniSTSRnor5.0
RGSC_v3.41234,394,271 - 234,394,332UniSTSRGSC3.4
Celera1225,520,749 - 225,520,810UniSTS
Cytogenetic Map1q52UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,383,396 - 228,384,384 (+)MAPPERmRatBN7.2
Rnor_6.01248,954,774 - 248,955,761NCBIRnor6.0
Rnor_6.01248,896,770 - 248,897,757NCBIRnor6.0
Rnor_5.01256,134,951 - 256,135,938UniSTSRnor5.0
Rnor_5.01256,193,802 - 256,194,789UniSTSRnor5.0
RGSC_v3.41234,394,621 - 234,395,608UniSTSRGSC3.4
Celera1225,521,099 - 225,522,086UniSTS
Cytogenetic Map1q52UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
Medium 2 2 2 6
Low 10 4 4 4 23 17 17 1
Below cutoff 6 6 4 1 4 34 9 13 3


RefSeq Acc Id: ENSRNOT00000015771   ⟹   ENSRNOP00000015771
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1248,954,244 - 248,956,446 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000074393   ⟹   ENSRNOP00000064286
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1228,381,521 - 228,385,202 (-)Ensembl
Rnor_6.0 Ensembl1248,895,738 - 248,898,607 (-)Ensembl
RefSeq Acc Id: NM_001106350   ⟹   NP_001099820
Rat AssemblyChrPosition (strand)Source
GRCr81237,794,969 - 237,798,650 (-)NCBI
mRatBN7.21228,381,521 - 228,385,202 (-)NCBI
Rnor_6.01248,952,896 - 248,956,579 (-)NCBI
Rnor_5.01256,133,073 - 256,136,756 (-)NCBI
RGSC_v3.41234,392,743 - 234,396,426 (-)RGD
Celera1225,519,220 - 225,522,904 (-)RGD
Protein Sequences
Protein RefSeqs NP_001099820 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AFI61655 (Get FASTA)   NCBI Sequence Viewer  
  EDM13121 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064286
RefSeq Acc Id: NP_001099820   ⟸   NM_001106350
- Peptide Label: precursor
- UniProtKB: D3Z9J1 (UniProtKB/TrEMBL),   A6I0Z0 (UniProtKB/TrEMBL),   M0R4J9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064286   ⟸   ENSRNOT00000074393
RefSeq Acc Id: ENSRNOP00000015771   ⟸   ENSRNOT00000015771
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9J1-F1-model_v2 AlphaFold D3Z9J1 1-270 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307313 AgrOrtholog
BioCyc Gene G2FUF-55938 BioCyc
Ensembl Genes ENSRNOG00000011692 Ensembl
  ENSRNOG00000048688 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074393 ENTREZGENE
  ENSRNOT00000074393.3 UniProtKB/TrEMBL
Gene3D-CATH Lipase, subunit A UniProtKB/TrEMBL
InterPro Dickkopf_N UniProtKB/TrEMBL
  DIKK1/2/4_C-subdom1 UniProtKB/TrEMBL
  DIKK1/2/4_C-subdom2 UniProtKB/TrEMBL
  DKK-like UniProtKB/TrEMBL
  Dkk1_Cys2 UniProtKB/TrEMBL
  Dkk1_N UniProtKB/TrEMBL
KEGG Report rno:293897 UniProtKB/TrEMBL
  PTHR12113 UniProtKB/TrEMBL
Pfam Dickkopf_N UniProtKB/TrEMBL
  DIKK1-2-4_C-subdom1 UniProtKB/TrEMBL
  DIKK1-2-4_C-subdom2 UniProtKB/TrEMBL
PhenoGen Dkk1 PhenoGen
RatGTEx ENSRNOG00000011692 RatGTEx
  ENSRNOG00000048688 RatGTEx
UniProt Secondary D3Z9J1 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Dkk1  dickkopf WNT signaling pathway inhibitor 1  NEWGENE_1307313  dickkopf WNT signaling pathway inhibitor 1  Data merged from RGD:11410606 737654 PROVISIONAL
2016-08-02 NEWGENE_1307313  dickkopf WNT signaling pathway inhibitor 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-05-22 Dkk1  dickkopf WNT signaling pathway inhibitor 1  Dkk1  dickkopf 1 homolog (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-12-06 Dkk1  dickkopf 1 homolog (Xenopus laevis)  Dkk1  dickkopf homolog 1 (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dkk1  dickkopf homolog 1 (Xenopus laevis)   Dkk1_predicted  dickkopf homolog 1 (Xenopus laevis) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dkk1_predicted  dickkopf homolog 1 (Xenopus laevis) (predicted)      Symbol and Name status set to approved 70820 APPROVED