Ddx3x (DEAD-box helicase 3, X-linked) - Rat Genome Database

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Gene: Ddx3x (DEAD-box helicase 3, X-linked) Rattus norvegicus
Analyze
Symbol: Ddx3x
Name: DEAD-box helicase 3, X-linked (Ensembl:DEAD box helicase 3, X-linked)
RGD ID: 1564771
Description: Predicted to enable several functions, including helicase activity; nucleic acid binding activity; and ribonucleoside triphosphate phosphatase activity. Predicted to be involved in several processes, including apoptotic signaling pathway; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Predicted to act upstream of or within with a negative effect on primary miRNA processing. Predicted to be located in several cellular components, including centrosome; cytoplasmic stress granule; and nucleoplasm. Predicted to be part of NLRP3 inflammasome complex. Predicted to be active in P granule and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked); PARTICIPATES IN Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-dependent RNA helicase DDX3X; DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X9,479,532 - 9,493,455 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX9,479,532 - 9,493,168 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX9,663,528 - 9,677,065 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X13,160,667 - 13,174,198 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X9,425,314 - 9,438,972 (-)NCBIRnor_WKY
Rnor_6.0X10,400,363 - 10,414,010 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX10,400,366 - 10,413,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X11,198,745 - 11,212,383 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X21,495,072 - 21,508,690 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX10,011,280 - 10,024,898 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
acetamide  (EXP)
acetazolamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aloxistatin  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
dibutyl phthalate  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
irinotecan  (EXP)
ivermectin  (ISO)
ketorolac  (ISO)
leflunomide  (ISO)
leupeptin  (ISO)
methidathion  (ISO)
methylparaben  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenol  (ISO)
piroxicam  (ISO)
poly(I:C)  (EXP)
pyrogallol  (ISO)
quizartinib  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rottlerin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IBA)
cellular response to arsenic-containing substance  (ISO)
cellular response to osmotic stress  (ISO)
cellular response to virus  (ISO)
chromosome segregation  (ISO)
cytosolic ribosome assembly  (ISO)
DNA duplex unwinding  (IEA)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
gamete generation  (IBA)
innate immune response  (ISO)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway  (ISO)
lipid homeostasis  (ISO)
negative regulation by host of viral genome replication  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of NIK/NF-kappaB signaling  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of translation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of protein acetylation  (ISO)
positive regulation of protein autophosphorylation  (ISO)
positive regulation of protein K63-linked ubiquitination  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of toll-like receptor 7 signaling pathway  (ISO)
positive regulation of toll-like receptor 8 signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of translation  (ISO)
positive regulation of translation in response to endoplasmic reticulum stress  (ISO)
positive regulation of translational initiation  (ISO)
positive regulation of viral genome replication  (ISO)
primary miRNA processing  (ISO)
protein localization to cytoplasmic stress granule  (ISO)
response to virus  (ISO)
RNA secondary structure unwinding  (ISO)
stress granule assembly  (ISO)
translational initiation  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss. Chan CH, etal., Mol Cancer Res. 2019 Feb;17(2):555-566. doi: 10.1158/1541-7786.MCR-18-0551. Epub 2018 Oct 8.
2. DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control. Chang PC, etal., Oncogene. 2006 Mar 30;25(14):1991-2003. doi: 10.1038/sj.onc.1209239.
3. Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3. Fu R, etal., Cell Death Dis. 2019 Aug 7;10(8):593. doi: 10.1038/s41419-019-1825-5.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis. He TY, etal., Sci Rep. 2016 Feb 19;6:21483. doi: 10.1038/srep21483.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer. Samal SK, etal., Sci Rep. 2015 Apr 28;5:9982. doi: 10.1038/srep09982.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. DDX3 as a strongest prognosis marker and its downregulation promotes metastasis in colorectal cancer. Su CY, etal., Oncotarget. 2015 Jul 30;6(21):18602-12.
13. Rottlerin upregulates DDX3 expression in hepatocellular carcinoma. Wang Z, etal., Biochem Biophys Res Commun. 2018 Jan 1;495(1):1503-1509. doi: 10.1016/j.bbrc.2017.11.198. Epub 2017 Dec 2.
14. DDX3 enhances oncogenic KRAS‑induced tumor invasion in colorectal cancer via the β‑catenin/ZEB1 axis. Wu DW, etal., Oncotarget. 2016 Apr 19;7(16):22687-99. doi: 10.18632/oncotarget.8143.
Additional References at PubMed
PMID:10074132   PMID:10329544   PMID:16818630   PMID:17667941   PMID:18583960   PMID:18596238   PMID:18628297   PMID:18636090   PMID:18846110   PMID:19056867   PMID:19199708   PMID:20458337  
PMID:20837705   PMID:20862261   PMID:21589879   PMID:21700703   PMID:21730191   PMID:21883093   PMID:22082260   PMID:22323517   PMID:22658674   PMID:22681889   PMID:22872150   PMID:23413191  
PMID:24380861   PMID:24625528   PMID:24965446   PMID:25468996   PMID:26100019   PMID:26235985   PMID:27546789   PMID:27736973   PMID:27980081   PMID:28128295   PMID:28733330   PMID:28819115  
PMID:28842590   PMID:29062139   PMID:29899501   PMID:30341167   PMID:31511697   PMID:32360748   PMID:35467791  


Genomics

Comparative Map Data
Ddx3x
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X9,479,532 - 9,493,455 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX9,479,532 - 9,493,168 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX9,663,528 - 9,677,065 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X13,160,667 - 13,174,198 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X9,425,314 - 9,438,972 (-)NCBIRnor_WKY
Rnor_6.0X10,400,363 - 10,414,010 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX10,400,366 - 10,413,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X11,198,745 - 11,212,383 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X21,495,072 - 21,508,690 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX10,011,280 - 10,024,898 (-)NCBICelera
Cytogenetic MapXq12NCBI
DDX3X
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X41,333,308 - 41,364,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX41,333,348 - 41,364,472 (+)EnsemblGRCh38hg38GRCh38
GRCh37X41,192,561 - 41,223,725 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X41,077,595 - 41,094,471 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X40,948,904 - 40,979,978NCBI
CeleraX45,333,407 - 45,350,283 (+)NCBICelera
Cytogenetic MapXp11.4NCBI
HuRefX38,924,970 - 38,941,587 (+)NCBIHuRef
CHM1_1X41,225,367 - 41,242,242 (+)NCBICHM1_1
T2T-CHM13v2.0X40,735,393 - 40,766,556 (+)NCBIT2T-CHM13v2.0
Ddx3x
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X13,147,261 - 13,160,222 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX13,147,209 - 13,160,291 (+)EnsemblGRCm39 Ensembl
GRCm38X13,280,496 - 13,293,988 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX13,280,970 - 13,294,052 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X12,858,148 - 12,871,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X12,437,997 - 12,449,573 (+)NCBIMGSCv36mm8
CeleraX10,940,806 - 10,968,272 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX8.17NCBI
Ddx3x
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555651,386,973 - 1,404,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555651,387,043 - 1,403,624 (-)NCBIChiLan1.0ChiLan1.0
DDX3X
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X41,474,515 - 41,491,479 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX41,475,116 - 41,505,837 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X33,780,381 - 33,796,829 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DDX3X
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X35,759,367 - 35,789,759 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX35,759,416 - 35,789,774 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX23,107,814 - 23,138,223 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X35,809,592 - 35,840,330 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX35,809,593 - 35,840,343 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X35,887,325 - 35,918,053 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X35,859,851 - 35,889,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X35,902,946 - 35,933,679 (+)NCBIUU_Cfam_GSD_1.0
Ddx3x
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X27,967,669 - 27,979,844 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365027,804,824 - 7,820,569 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365027,770,896 - 7,820,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDX3X
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX36,988,031 - 37,018,202 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X36,988,031 - 37,005,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X41,162,232 - 41,177,756 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DDX3X
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X38,513,251 - 38,539,982 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660763,696,930 - 3,714,667 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddx3x
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476214,290,267 - 14,305,633 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476214,290,267 - 14,305,437 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ddx3x
34 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:557
Count of miRNA genes:275
Interacting mature miRNAs:356
Transcripts:ENSRNOT00000039551
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat

Markers in Region
L25126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X9,481,913 - 9,482,019 (+)MAPPERmRatBN7.2
Rnor_6.0X10,402,745 - 10,402,850NCBIRnor6.0
Rnor_5.0X11,201,127 - 11,201,232UniSTSRnor5.0
RGSC_v3.4X21,497,451 - 21,497,556UniSTSRGSC3.4
CeleraX10,013,659 - 10,013,764UniSTS
Cytogenetic MapXq12UniSTS
SHGC-33274  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X9,480,579 - 9,480,704 (+)MAPPERmRatBN7.2
Rnor_6.0X10,401,411 - 10,401,535NCBIRnor6.0
Rnor_5.0X11,199,793 - 11,199,917UniSTSRnor5.0
RGSC_v3.4X21,496,117 - 21,496,241UniSTSRGSC3.4
CeleraX10,012,325 - 10,012,449UniSTS
Cytogenetic MapXq12UniSTS
Ddx3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X9,481,644 - 9,481,917 (+)MAPPERmRatBN7.2
Rnor_6.0X10,402,476 - 10,402,748NCBIRnor6.0
Rnor_5.0X11,200,858 - 11,201,130UniSTSRnor5.0
RGSC_v3.4X21,497,182 - 21,497,454UniSTSRGSC3.4
CeleraX10,013,390 - 10,013,662UniSTS
Cytogenetic MapXq12UniSTS
DBX  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X116,167,281 - 116,167,369 (+)MAPPERmRatBN7.2
mRatBN7.2X9,479,848 - 9,479,935 (+)MAPPERmRatBN7.2
Rnor_6.0X123,538,974 - 123,539,061NCBIRnor6.0
Rnor_6.0X10,400,680 - 10,400,766NCBIRnor6.0
Rnor_5.0X123,683,915 - 123,684,002UniSTSRnor5.0
Rnor_5.0X11,199,062 - 11,199,148UniSTSRnor5.0
RGSC_v3.4X21,495,386 - 21,495,472UniSTSRGSC3.4
RGSC_v3.4X7,939,396 - 7,939,483UniSTSRGSC3.4
CeleraX115,397,167 - 115,397,254UniSTS
CeleraX10,011,594 - 10,011,680UniSTS
Cytogenetic MapXq12UniSTS
RH78345  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X9,480,580 - 9,480,704 (+)MAPPERmRatBN7.2
Rnor_6.0X10,401,412 - 10,401,535NCBIRnor6.0
Rnor_5.0X11,199,794 - 11,199,917UniSTSRnor5.0
RGSC_v3.4X21,496,118 - 21,496,241UniSTSRGSC3.4
CeleraX10,012,326 - 10,012,449UniSTS
Cytogenetic MapXq12UniSTS
RH127853  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X9,479,646 - 9,479,832 (+)MAPPERmRatBN7.2
Rnor_6.0X10,400,478 - 10,400,663NCBIRnor6.0
Rnor_5.0X11,198,860 - 11,199,045UniSTSRnor5.0
RGSC_v3.4X21,495,184 - 21,495,369UniSTSRGSC3.4
CeleraX10,011,392 - 10,011,577UniSTS
Cytogenetic MapXq12UniSTS
U42386  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X9,480,389 - 9,480,540 (+)MAPPERmRatBN7.2
Rnor_6.0X10,401,221 - 10,401,371NCBIRnor6.0
Rnor_5.0X11,199,603 - 11,199,753UniSTSRnor5.0
RGSC_v3.4X21,495,927 - 21,496,077UniSTSRGSC3.4
CeleraX10,012,135 - 10,012,285UniSTS
Cytogenetic MapXq12UniSTS
Ddx3x  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X9,481,040 - 9,481,952 (+)MAPPERmRatBN7.2
Rnor_6.0X10,401,872 - 10,402,783NCBIRnor6.0
Rnor_5.0X11,200,254 - 11,201,165UniSTSRnor5.0
RGSC_v3.4X21,496,578 - 21,497,489UniSTSRGSC3.4
CeleraX10,012,786 - 10,013,697UniSTS
Cytogenetic MapXq12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000039551   ⟹   ENSRNOP00000029702
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX9,479,532 - 9,493,168 (-)Ensembl
Rnor_6.0 EnsemblX10,400,366 - 10,413,984 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091448   ⟹   ENSRNOP00000074025
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX9,482,093 - 9,488,086 (-)Ensembl
Rnor_6.0 EnsemblX10,402,725 - 10,413,995 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112352   ⟹   ENSRNOP00000090648
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX9,479,532 - 9,488,630 (-)Ensembl
RefSeq Acc Id: NM_001108246   ⟹   NP_001101716
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X9,479,535 - 9,493,153 (-)NCBI
Rnor_6.0X10,400,366 - 10,413,984 (-)NCBI
Rnor_5.0X11,198,745 - 11,212,383 (-)NCBI
RGSC_v3.4X21,495,072 - 21,508,690 (-)RGD
CeleraX10,011,280 - 10,024,898 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256652   ⟹   XP_006256714
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X9,479,532 - 9,493,445 (-)NCBI
Rnor_6.0X10,400,363 - 10,414,010 (-)NCBI
Rnor_5.0X11,198,745 - 11,212,383 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256653   ⟹   XP_006256715
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X9,479,597 - 9,493,455 (-)NCBI
Rnor_6.0X10,400,363 - 10,413,999 (-)NCBI
Rnor_5.0X11,198,745 - 11,212,383 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001101716   ⟸   NM_001108246
- Sequence:
RefSeq Acc Id: XP_006256715   ⟸   XM_006256653
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006256714   ⟸   XM_006256652
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K719 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074025   ⟸   ENSRNOT00000091448
RefSeq Acc Id: ENSRNOP00000029702   ⟸   ENSRNOT00000039551
RefSeq Acc Id: ENSRNOP00000090648   ⟸   ENSRNOT00000112352
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K719-F1-model_v2 AlphaFold A0A0G2K719 1-662 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701711
Promoter ID:EPDNEW_R12229
Type:multiple initiation site
Name:Ddx3x_1
Description:DEAD-box helicase 3, X-linked
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X10,413,999 - 10,414,059EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564771 AgrOrtholog
BioCyc Gene G2FUF-3085 BioCyc
Ensembl Genes ENSRNOG00000023383 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000029702 ENTREZGENE
  ENSRNOP00000029702.6 UniProtKB/TrEMBL
  ENSRNOP00000074025.2 UniProtKB/TrEMBL
  ENSRNOP00000090648 ENTREZGENE
  ENSRNOP00000090648.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039551 ENTREZGENE
  ENSRNOT00000039551.7 UniProtKB/TrEMBL
  ENSRNOT00000091448.2 UniProtKB/TrEMBL
  ENSRNOT00000112352 ENTREZGENE
  ENSRNOT00000112352.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7107275 IMAGE-MGC_LOAD
InterPro DEAD/DEAH_box_helicase_dom UniProtKB/TrEMBL
  DNA/RNA_helicase_C UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RNA-helicase_DEAD-box_CS UniProtKB/TrEMBL
  RNA_helicase_DEAD_Q_motif UniProtKB/TrEMBL
KEGG Report rno:317335 UniProtKB/TrEMBL
MGC_CLONE MGC:94798 IMAGE-MGC_LOAD
NCBI Gene 317335 ENTREZGENE
Pfam DEAD UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
PhenoGen Ddx3x PhenoGen
PROSITE DEAD_ATP_HELICASE UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  Q_MOTIF UniProtKB/TrEMBL
SMART DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2K719 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACZ0_RAT UniProtKB/TrEMBL
  D4ADE8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Ddx3x  DEAD-box helicase 3, X-linked  Ddx3x  DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-01 Ddx3x  DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked  Ddx3x  DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Ddx3x  DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked  Ddx3x  DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ddx3x  DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked    DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked  Name updated 1299863 APPROVED
2006-02-09 Ddx3x  DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked      Symbol and Name status set to provisional 70820 PROVISIONAL