Haghl (hydroxyacylglutathione hydrolase-like) - Rat Genome Database

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Gene: Haghl (hydroxyacylglutathione hydrolase-like) Rattus norvegicus
Analyze
Symbol: Haghl
Name: hydroxyacylglutathione hydrolase-like
RGD ID: 1308042
Description: Predicted to enable hydroxyacylglutathione hydrolase activity. Predicted to be involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Orthologous to human HAGHL (hydroxyacylglutathione hydrolase like); INTERACTS WITH acrylamide; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC302995
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21014,804,957 - 14,809,495 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,804,997 - 14,807,665 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01015,152,736 - 15,157,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,152,709 - 15,155,412 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,965,679 - 14,970,103 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,050,382 - 15,053,046 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,050,381 - 15,053,046 (-)NCBI
Celera1014,473,975 - 14,478,442 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
Haghl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21014,804,957 - 14,809,495 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,804,997 - 14,807,665 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01015,152,736 - 15,157,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,152,709 - 15,155,412 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,965,679 - 14,970,103 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,050,382 - 15,053,046 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,050,381 - 15,053,046 (-)NCBI
Celera1014,473,975 - 14,478,442 (-)NCBICelera
Cytogenetic Map10q12NCBI
HAGHL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816727,106 - 729,715 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl16726,936 - 735,525 (+)EnsemblGRCh38hg38GRCh38
GRCh3716777,106 - 779,715 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616716,959 - 719,716 (+)NCBINCBI36Build 36hg18NCBI36
Celera16977,123 - 979,880 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16699,167 - 701,303 (+)NCBIHuRef
CHM1_116777,236 - 779,685 (+)NCBICHM1_1
T2T-CHM13v2.016731,280 - 733,889 (+)NCBIT2T-CHM13v2.0
Haghl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,998,817 - 26,004,560 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,998,817 - 26,004,647 (-)EnsemblGRCm39 Ensembl
GRCm381725,779,843 - 25,785,586 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,779,843 - 25,785,673 (-)EnsemblGRCm38mm10GRCm38
MGSCv371725,919,770 - 25,922,278 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361725,510,425 - 25,512,933 (-)NCBIMGSCv36mm8
Celera1726,315,631 - 26,318,139 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
Haghl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,475,384 - 16,477,623 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544216,475,155 - 16,478,147 (-)NCBIChiLan1.0ChiLan1.0
HAGHL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.116740,489 - 742,780 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16740,574 - 742,521 (+)Ensemblpanpan1.1panPan2
HAGHL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,853,979 - 39,857,041 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,854,038 - 39,857,283 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,118,702 - 41,121,047 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,197,115 - 40,200,176 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,197,122 - 40,199,765 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1639,885,785 - 39,888,129 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,845,998 - 39,848,343 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,324,873 - 40,327,218 (-)NCBIUU_Cfam_GSD_1.0
Haghl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,189,093 - 112,192,218 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936501287,013 - 290,062 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936501286,958 - 290,062 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAGHL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,046,171 - 41,053,464 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,050,047 - 41,053,797 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,423,972 - 41,427,865 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HAGHL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.15646,321 - 649,411 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606830,486,272 - 30,489,228 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Haghl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,536,147 - 1,537,803 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249131,535,751 - 1,538,516 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Haghl
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:102
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000026536
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat

Markers in Region
RH131615  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,804,749 - 14,804,952 (+)MAPPERmRatBN7.2
Rnor_6.01015,152,506 - 15,152,708NCBIRnor6.0
Rnor_5.01014,965,449 - 14,965,651UniSTSRnor5.0
RGSC_v3.41015,050,150 - 15,050,352UniSTSRGSC3.4
Celera1014,473,745 - 14,473,947UniSTS
RH 3.4 Map10155.1UniSTS
Cytogenetic Map10q12UniSTS
RH132046  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 64 16 23
Low 3 43 33 17 19 17 8 11 10 19 18 11 8
Below cutoff 24 24 24

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026536   ⟹   ENSRNOP00000026536
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1014,804,997 - 14,807,665 (-)Ensembl
Rnor_6.0 Ensembl1015,152,709 - 15,155,412 (-)Ensembl
RefSeq Acc Id: XM_003750790   ⟹   XP_003750838
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,804,957 - 14,809,490 (-)NCBI
Rnor_6.01015,152,736 - 15,157,221 (-)NCBI
Rnor_5.01014,965,679 - 14,970,103 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246064   ⟹   XP_006246126
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,804,957 - 14,809,492 (-)NCBI
Rnor_6.01015,152,736 - 15,157,221 (-)NCBI
Rnor_5.01014,965,679 - 14,970,103 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246065   ⟹   XP_006246127
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,804,957 - 14,807,234 (-)NCBI
Rnor_6.01015,152,736 - 15,154,940 (-)NCBI
Rnor_5.01014,965,679 - 14,970,103 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039087112   ⟹   XP_038943040
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,804,957 - 14,807,769 (-)NCBI
RefSeq Acc Id: XM_039087113   ⟹   XP_038943041
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,804,957 - 14,809,495 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_003750838   ⟸   XM_003750790
- Peptide Label: isoform X2
- UniProtKB: D4A2F7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246126   ⟸   XM_006246064
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006246127   ⟸   XM_006246065
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000026536   ⟸   ENSRNOT00000026536
RefSeq Acc Id: XP_038943041   ⟸   XM_039087113
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038943040   ⟸   XM_039087112
- Peptide Label: isoform X1
Protein Domains
Metallo-beta-lactamase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2F7-F1-model_v2 AlphaFold D4A2F7 1-283 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697060
Promoter ID:EPDNEW_R7582
Type:multiple initiation site
Name:Haghl_1
Description:hydroxyacylglutathione hydrolase-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01015,155,422 - 15,155,482EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308042 AgrOrtholog
BioCyc Gene G2FUF-25761 BioCyc
Ensembl Genes ENSRNOG00000019612 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000026536 ENTREZGENE
  ENSRNOP00000026536.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026536 ENTREZGENE
  ENSRNOT00000026536.7 UniProtKB/TrEMBL
Gene3D-CATH 3.60.15.10 UniProtKB/TrEMBL
InterPro Beta-lactamas-like UniProtKB/TrEMBL
  Clx_II_MBL UniProtKB/TrEMBL
  HAGH_C UniProtKB/TrEMBL
  Hydroxyacylglutathione_Hdrlase UniProtKB/TrEMBL
  Metallo-hydrolase/OxRdtase UniProtKB/TrEMBL
KEGG Report rno:302995 UniProtKB/TrEMBL
NCBI Gene 302995 ENTREZGENE
PANTHER BETA LACTAMASE DOMAIN UniProtKB/TrEMBL
  HYDROXYACYLGLUTATHIONE HYDROLASE-LIKE PROTEIN UniProtKB/TrEMBL
Pfam HAGH_C UniProtKB/TrEMBL
  Lactamase_B UniProtKB/TrEMBL
PhenoGen Haghl PhenoGen
SMART Lactamase_B UniProtKB/TrEMBL
Superfamily-SCOP SSF56281 UniProtKB/TrEMBL
TIGRFAMs GSH_gloB UniProtKB/TrEMBL
UniProt D4A2F7 ENTREZGENE, UniProtKB/TrEMBL
  Q6DGG3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Haghl  hydroxyacylglutathione hydrolase-like  LOC100365011  hypothetical LOC100365011  Data Merged 1643240 APPROVED
2010-05-05 LOC100365011  hypothetical LOC100365011      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Haghl  hydroxyacylglutathione hydrolase-like  Haghl_predicted  hydroxyacylglutathione hydrolase-like (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Haghl_predicted  hydroxyacylglutathione hydrolase-like (predicted)      Symbol and Name status set to approved 70820 APPROVED