Folh1 (folate hydrolase 1) - Rat Genome Database

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Gene: Folh1 (folate hydrolase 1) Rattus norvegicus
Analyze
Symbol: Folh1
Name: folate hydrolase 1
RGD ID: 70963
Description: Predicted to enable Ac-Asp-Glu binding activity; exopeptidase activity; and tetrahydrofolyl-poly(glutamate) polymer binding activity. Involved in positive regulation of apoptotic process and protein catabolic process. Predicted to be located in cell surface and membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and cerebral infarction. Orthologous to several human genes including FOLH1 (folate hydrolase 1); PARTICIPATES IN folate cycle metabolic pathway; folate metabolic pathway; folate mediated one-carbon metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FGCP; folate hydrolase; folylpoly-gamma-glutamate carboxypeptidase; GCPII; glutamate carboxypeptidase 2; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; mGCP; N-acetylated alpha-linked acidic dipeptidase; N-acetylated-alpha-linked acidic dipeptidase I; Naalad; NAALADase I; prostate-specific membrane antigen homolog; pteroylpoly-gamma-glutamate carboxypeptidase
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81149,828,286 - 149,914,313 (-)NCBIGRCr8
mRatBN7.21140,428,101 - 140,501,563 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1140,428,101 - 140,501,379 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1148,335,238 - 148,426,869 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01155,505,880 - 155,597,520 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01148,379,807 - 148,471,432 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01150,323,768 - 150,395,415 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1150,323,768 - 150,395,415 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01156,631,301 - 156,702,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41142,936,379 - 143,010,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11143,014,784 - 143,088,764 (-)NCBI
Celera1138,771,206 - 138,844,472 (-)NCBICelera
RH 3.4 Map11111.7RGD
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (ISO)
membrane  (ISO)
plasma membrane  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. Blom HJ and Smulders Y, J Inherit Metab Dis. 2011 Feb;34(1):75-81. doi: 10.1007/s10545-010-9177-4. Epub 2010 Sep 4.
2. Molecular cloning of a peptidase against N-acetylaspartylglutamate from a rat hippocampal cDNA library. Bzdega T, etal., J Neurochem 1997 Dec;69(6):2270-7.
3. Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase. Carter RE, etal., Proc Natl Acad Sci U S A 1996 Jan 23;93(2):749-53.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Ghadge GD, etal., Proc Natl Acad Sci U S A 2003 Aug 5;100(16):9554-9. Epub 2003 Jul 22.
6. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. Giusti B, etal., J Med Genet. 2008 Nov;45(11):721-30. doi: 10.1136/jmg.2008.057851. Epub 2008 Jul 17.
7. Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism. Giusti B, etal., Thromb Haemost. 2010 Aug;104(2):231-42. doi: 10.1160/TH09-11-0748. Epub 2010 May 10.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Israeli RS, etal., Cancer Res 1993 Jan 15;53(2):227-30.
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II. Luthi-Carter R, etal., Proc Natl Acad Sci U S A 1998 Mar 17;95(6):3215-20.
12. Gene Data Set MGD Curation, June 12, 2002
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells. Pinto JT, etal., Clin Cancer Res. 1996 Sep;2(9):1445-51.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Gamma-glutamyl hydrolase and drug resistance. Schneider E and Ryan TJ, Clin Chim Acta. 2006 Dec;374(1-2):25-32. Epub 2006 Jun 10.
Additional References at PubMed
PMID:11210180   PMID:12949938   PMID:15019832   PMID:15030392   PMID:17241121   PMID:18076021   PMID:21908619   PMID:22570482   PMID:23533145   PMID:24863754   PMID:30113208  


Genomics

Comparative Map Data
Folh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81149,828,286 - 149,914,313 (-)NCBIGRCr8
mRatBN7.21140,428,101 - 140,501,563 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1140,428,101 - 140,501,379 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1148,335,238 - 148,426,869 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01155,505,880 - 155,597,520 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01148,379,807 - 148,471,432 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01150,323,768 - 150,395,415 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1150,323,768 - 150,395,415 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01156,631,301 - 156,702,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41142,936,379 - 143,010,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11143,014,784 - 143,088,764 (-)NCBI
Celera1138,771,206 - 138,844,472 (-)NCBICelera
RH 3.4 Map11111.7RGD
Cytogenetic Map1q32NCBI
FOLH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381149,145,092 - 49,208,602 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1149,145,092 - 49,208,638 (-)EnsemblGRCh38hg38GRCh38
GRCh371149,166,644 - 49,230,154 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,124,763 - 49,186,798 (-)NCBINCBI36Build 36hg18NCBI36
Build 341149,124,763 - 49,186,798NCBI
Celera1149,319,516 - 49,381,546 (-)NCBICelera
Cytogenetic Map11p11.12NCBI
HuRef1148,886,315 - 48,948,370 (-)NCBIHuRef
CHM1_11149,166,592 - 49,228,610 (-)NCBICHM1_1
T2T-CHM13v2.01149,322,228 - 49,385,778 (-)NCBIT2T-CHM13v2.0
Folh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39786,365,733 - 86,425,171 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl786,368,185 - 86,425,151 (-)EnsemblGRCm39 Ensembl
GRCm38786,716,525 - 86,776,053 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl786,718,977 - 86,775,943 (-)EnsemblGRCm38mm10GRCm38
MGSCv37793,867,486 - 93,924,374 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36786,594,748 - 86,651,592 (-)NCBIMGSCv36mm8
Celera784,090,600 - 84,151,262 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map748.51NCBI
FOLH1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12110,401,129 - 10,466,162 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2110,203,492 - 10,466,161 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2110,252,624 - 10,317,104 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02110,582,575 - 10,647,371 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2110,581,865 - 10,647,452 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12110,371,141 - 10,435,721 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02110,429,798 - 10,494,435 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02110,486,267 - 10,550,766 (-)NCBIUU_Cfam_GSD_1.0
FOLH1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl922,903,979 - 22,963,472 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1922,903,997 - 22,960,648 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2925,630,162 - 25,687,739 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Folh1
604 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:38
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000018592
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat

Markers in Region
AU014956  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21140,483,312 - 140,483,539 (+)MAPPERmRatBN7.2
Rnor_6.01150,377,349 - 150,377,575NCBIRnor6.0
Rnor_5.01156,684,882 - 156,685,108UniSTSRnor5.0
RGSC_v3.41142,992,292 - 142,992,518UniSTSRGSC3.4
Celera1138,826,406 - 138,826,632UniSTS
Cytogenetic Map1q32UniSTS
Folh1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21140,434,040 - 140,434,160 (+)MAPPERmRatBN7.2
Rnor_6.01150,329,708 - 150,329,827NCBIRnor6.0
Rnor_5.01156,637,241 - 156,637,360UniSTSRnor5.0
RGSC_v3.41142,942,319 - 142,942,438UniSTSRGSC3.4
Celera1138,777,146 - 138,777,265UniSTS
RH 3.4 Map11111.7UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 10 39 113 86 85 55 23 55 6 197 84 93 43 57 30

Sequence


Ensembl Acc Id: ENSRNOT00000018592   ⟹   ENSRNOP00000018592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1140,428,101 - 140,501,379 (-)Ensembl
Rnor_6.0 Ensembl1150,323,768 - 150,395,415 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103049   ⟹   ENSRNOP00000088905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1140,428,101 - 140,501,379 (-)Ensembl
RefSeq Acc Id: NM_057185   ⟹   NP_476533
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,840,760 - 149,914,035 (-)NCBI
mRatBN7.21140,428,101 - 140,501,379 (-)NCBI
Rnor_6.01150,323,768 - 150,395,415 (-)NCBI
Rnor_5.01156,631,301 - 156,702,948 (-)NCBI
RGSC_v3.41142,936,379 - 143,010,358 (-)RGD
Celera1138,771,206 - 138,844,472 (-)RGD
Sequence:
RefSeq Acc Id: XM_039092938   ⟹   XP_038948866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,828,286 - 149,910,893 (-)NCBI
mRatBN7.21140,428,770 - 140,498,237 (-)NCBI
RefSeq Acc Id: XM_063275902   ⟹   XP_063131972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,828,286 - 149,914,133 (-)NCBI
RefSeq Acc Id: XM_063275904   ⟹   XP_063131974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,828,286 - 149,914,084 (-)NCBI
RefSeq Acc Id: XM_063275907   ⟹   XP_063131977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,849,317 - 149,914,088 (-)NCBI
RefSeq Acc Id: XM_063275908   ⟹   XP_063131978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,853,409 - 149,914,095 (-)NCBI
RefSeq Acc Id: XM_063275909   ⟹   XP_063131979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81149,849,317 - 149,914,313 (-)NCBI
RefSeq Acc Id: NP_476533   ⟸   NM_057185
- UniProtKB: Q547B6 (UniProtKB/Swiss-Prot),   P70627 (UniProtKB/Swiss-Prot),   G3V7S0 (UniProtKB/TrEMBL),   A6I5Y1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018592   ⟸   ENSRNOT00000018592
RefSeq Acc Id: XP_038948866   ⟸   XM_039092938
- Peptide Label: isoform X2
- UniProtKB: Q547B6 (UniProtKB/Swiss-Prot),   P70627 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000088905   ⟸   ENSRNOT00000103049
RefSeq Acc Id: XP_063131972   ⟸   XM_063275902
- Peptide Label: isoform X1
- UniProtKB: Q547B6 (UniProtKB/Swiss-Prot),   P70627 (UniProtKB/Swiss-Prot),   A6I5Y1 (UniProtKB/TrEMBL),   G3V7S0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131974   ⟸   XM_063275904
- Peptide Label: isoform X1
- UniProtKB: Q547B6 (UniProtKB/Swiss-Prot),   P70627 (UniProtKB/Swiss-Prot),   A6I5Y1 (UniProtKB/TrEMBL),   G3V7S0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131979   ⟸   XM_063275909
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063131977   ⟸   XM_063275907
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063131978   ⟸   XM_063275908
- Peptide Label: isoform X4
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70627-F1-model_v2 AlphaFold P70627 1-752 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690175
Promoter ID:EPDNEW_R700
Type:single initiation site
Name:Folh1_1
Description:folate hydrolase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01150,395,421 - 150,395,481EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70963 AgrOrtholog
BioCyc Gene G2FUF-58597 BioCyc
Ensembl Genes ENSRNOG00000013770 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055019273 UniProtKB/Swiss-Prot
  ENSRNOG00060020113 UniProtKB/Swiss-Prot
  ENSRNOG00065028510 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018592.4 UniProtKB/TrEMBL
  ENSRNOT00000103049.1 UniProtKB/TrEMBL
  ENSRNOT00055032884 UniProtKB/Swiss-Prot
  ENSRNOT00060034803 UniProtKB/Swiss-Prot
  ENSRNOT00065049180 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.930.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.30.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zn peptidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M28B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFR-like_dimer_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFR-like_dimer_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85309 UniProtKB/Swiss-Prot
NCBI Gene 85309 ENTREZGENE
PANTHER GLUTAMATE CARBOXYPEPTIDASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10404 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF02225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFR_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Folh1 PhenoGen
RatGTEx ENSRNOG00000013770 RatGTEx
  ENSRNOG00055019273 RatGTEx
  ENSRNOG00060020113 RatGTEx
  ENSRNOG00065028510 RatGTEx
Superfamily-SCOP PA domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47672 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zn-dependent exopeptidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ABM7_RAT UniProtKB/TrEMBL
  A6I5Y1 ENTREZGENE, UniProtKB/TrEMBL
  FOLH1_RAT UniProtKB/Swiss-Prot
  G3V7S0 ENTREZGENE, UniProtKB/TrEMBL
  P70627 ENTREZGENE
  Q547B6 ENTREZGENE
UniProt Secondary Q547B6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-15 Folh1  folate hydrolase 1  Folh1  folate hydrolase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Folh1  folate hydrolase      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in astrocytes 728645