Gucy1a1 (guanylate cyclase 1 soluble subunit alpha 1) - Rat Genome Database

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Gene: Gucy1a1 (guanylate cyclase 1 soluble subunit alpha 1) Rattus norvegicus
Analyze
Symbol: Gucy1a1
Name: guanylate cyclase 1 soluble subunit alpha 1
RGD ID: 68436
Description: Enables ion binding activity. Contributes to adenylate cyclase activity and cytidylate cyclase activity. Involved in response to herbicide and response to organic cyclic compound. Part of guanylate cyclase complex, soluble. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1); PARTICIPATES IN long term depression; purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GCS-alpha-1; GCS-alpha-3; guanylate cyclase 1 soluble subunit alpha 3; guanylate cyclase 1, soluble, alpha 3; Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase); guanylate cyclase soluble subunit alpha-1; guanylate cyclase soluble subunit alpha-3; Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase); Gucy1a3; SGC; soluble guanylate cyclase; soluble guanylate cyclase large subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Gucy1a3em1Mcwi  
Genetic Models: SS-Gucy1a3em1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22167,418,615 - 167,482,293 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2167,418,640 - 167,481,671 (-)Ensembl
Rnor_6.02181,045,694 - 181,103,321 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2181,045,703 - 181,102,918 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02200,453,480 - 200,515,219 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,756,824 - 173,818,316 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12173,705,122 - 173,768,506 (-)NCBI
Celera2161,450,514 - 161,511,622 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic GMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
apocynin  (EXP)
aristolochic acid  (ISO)
arotinoid acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CHIR 99021  (ISO)
chloroprene  (EXP,ISO)
cinaciguat  (EXP,ISO)
clobetasol  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
diethyl malate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
ferroheme b  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
glafenine  (EXP)
GTP  (ISO)
heme b  (EXP)
hydrogen peroxide  (EXP)
hydroxocobalamin  (ISO)
isoflavones  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
menadione  (EXP)
methylseleninic acid  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
nitroglycerin  (EXP)
nitroprusside  (EXP)
NONOate(1-)  (ISO)
oxaliplatin  (EXP)
p-toluidine  (EXP)
panobinostat  (ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
potassium hexacyanoferrate(3-)  (ISO)
progesterone  (EXP)
protoporphyrin  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
Soman  (EXP)
taurine  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
XAV939  (ISO)
zinc protoporphyrin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Almanza A, etal., J Neurophysiol. 2007 Feb;97(2):1188-95. Epub 2006 Dec 20.
2. Azam M, etal., Hypertension 1998 Jul;32(1):149-54.
3. Baltrons MA, etal., Neurobiol Dis 2002 Jul;10(2):139-49.
4. Beste KY, etal., Biochemistry. 2012 Jan 10;51(1):194-204. doi: 10.1021/bi201259y. Epub 2011 Dec 13.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. GOA data from the GO Consortium
7. KEGG
8. Kloss S, etal., J Biol Chem 2003 Jan 24;278(4):2377-83.
9. Legg RL, etal., Reprod Biol Endocrinol. 2008 Nov 24;6:57.
10. MGD data from the GO Consortium
11. Moran JM, etal., Nitric Oxide. 2010 Apr 11.
12. Nakane M, etal., J Biol Chem 1990 Oct 5;265(28):16841-5.
13. NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Nedvetsky PI, etal., Brain Res 2002 Sep 20;950(1-2):148-54.
15. OMIM Disease Annotation Pipeline
16. Papapetropoulos A, etal., Mol Pharmacol. 2005 Oct;68(4):1133-41. Epub 2005 Jul 15.
17. Pipeline to import KEGG annotations from KEGG into RGD
18. RGD automated data pipeline
19. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. RGD automated import pipeline for gene-chemical interactions
21. Smigrodzki R and Levitt P, Brain Res Dev Brain Res 1996 Dec 23;97(2):226-34.
22. Tao YX and Johns RA, Neuroscience 2002;112(2):439-46.
23. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Winger JA, etal., J Biol Chem. 2007 Jan 12;282(2):897-907. Epub 2006 Nov 10.
Additional References at PubMed
PMID:12477932   PMID:14749300   PMID:14754757   PMID:16131543   PMID:16489110   PMID:16614755   PMID:17170090   PMID:18022154   PMID:18474600   PMID:18550612   PMID:18572161   PMID:18635821  
PMID:19141686   PMID:19466990   PMID:20009348   PMID:20023176   PMID:20353168   PMID:20459051   PMID:22806360   PMID:23093402   PMID:23505436   PMID:24982890   PMID:27009048   PMID:27923787  
PMID:28782641   PMID:30260287   PMID:32358060   PMID:35089807  


Genomics

Comparative Map Data
Gucy1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22167,418,615 - 167,482,293 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2167,418,640 - 167,481,671 (-)Ensembl
Rnor_6.02181,045,694 - 181,103,321 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2181,045,703 - 181,102,918 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02200,453,480 - 200,515,219 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,756,824 - 173,818,316 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12173,705,122 - 173,768,506 (-)NCBI
Celera2161,450,514 - 161,511,622 (-)NCBICelera
Cytogenetic Map2q34NCBI
GUCY1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384155,666,848 - 155,737,059 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4155,666,726 - 155,737,059 (+)EnsemblGRCh38hg38GRCh38
GRCh374156,588,000 - 156,658,211 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364156,807,328 - 156,871,232 (+)NCBINCBI36hg18NCBI36
Build 344156,945,482 - 157,009,379NCBI
Celera4153,919,477 - 153,989,823 (+)NCBI
Cytogenetic Map4q32.1NCBI
HuRef4152,327,271 - 152,397,264 (+)NCBIHuRef
CHM1_14156,565,607 - 156,635,931 (+)NCBICHM1_1
Gucy1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39381,999,734 - 82,053,253 (-)NCBIGRCm39mm39
GRCm39 Ensembl381,999,734 - 82,053,096 (-)Ensembl
GRCm38382,092,427 - 82,145,946 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl382,092,427 - 82,145,789 (-)EnsemblGRCm38mm10GRCm38
MGSCv37381,896,349 - 81,949,799 (-)NCBIGRCm37mm9NCBIm37
MGSCv36382,178,354 - 82,231,000 (-)NCBImm8
Celera382,117,270 - 82,170,809 (-)NCBICelera
Cytogenetic Map3E3NCBI
Gucy1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547111,367,282 - 11,424,273 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547111,367,318 - 11,422,199 (-)NCBIChiLan1.0ChiLan1.0
GUCY1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14159,850,092 - 159,920,159 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4159,850,107 - 159,913,338 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04148,032,167 - 148,102,757 (+)NCBIMhudiblu_PPA_v0panPan3
GUCY1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11553,172,914 - 53,236,200 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1553,174,157 - 53,234,533 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1553,510,720 - 53,570,219 (+)NCBI
ROS_Cfam_1.01553,880,516 - 53,943,086 (+)NCBI
ROS_Cfam_1.0 Ensembl1553,881,077 - 53,942,856 (+)Ensembl
UMICH_Zoey_3.11553,134,895 - 53,194,847 (+)NCBI
UNSW_CanFamBas_1.01553,244,742 - 53,304,495 (+)NCBI
UU_Cfam_GSD_1.01553,557,797 - 53,618,055 (+)NCBI
Gucy1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530137,135,116 - 37,192,728 (-)NCBI
SpeTri2.0NW_0049365762,353,874 - 2,411,747 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCY1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl844,449,232 - 44,518,135 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1844,448,758 - 44,520,737 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2846,457,572 - 46,537,279 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GUCY1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17102,206,438 - 102,310,535 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl7102,238,477 - 102,303,673 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603781,715,008 - 81,968,286 (+)NCBIVero_WHO_p1.0
Gucy1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248482,522,935 - 2,588,758 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH133297  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22167,418,677 - 167,418,858 (+)MAPPERmRatBN7.2
Rnor_6.02181,045,757 - 181,045,937NCBIRnor6.0
Rnor_5.02200,453,543 - 200,453,723UniSTSRnor5.0
RGSC_v3.42173,755,055 - 173,755,235UniSTSRGSC3.4
Celera2161,448,745 - 161,448,925UniSTS
RH 3.4 Map21090.1UniSTS
Cytogenetic Map2q33UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147686913168355276Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat


Genetic Models
This gene Gucy1a1 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:550
Count of miRNA genes:260
Interacting mature miRNAs:337
Transcripts:ENSRNOT00000017190
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 37 30 14 19 14 2 2 62 33 31 11 2
Low 1 6 27 27 27 6 9 12 2 10 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017190   ⟹   ENSRNOP00000017190
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2167,418,640 - 167,481,671 (-)Ensembl
Rnor_6.0 Ensembl2181,045,703 - 181,102,918 (-)Ensembl
RefSeq Acc Id: NM_017090   ⟹   NP_058786
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22167,420,447 - 167,481,557 (-)NCBI
Rnor_6.02181,047,526 - 181,102,793 (-)NCBI
Rnor_5.02200,453,480 - 200,515,219 (-)NCBI
RGSC_v3.42173,756,824 - 173,818,316 (-)RGD
Celera2161,450,514 - 161,511,622 (-)RGD
Sequence:
RefSeq Acc Id: XM_006232518   ⟹   XP_006232580
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22167,418,615 - 167,482,293 (-)NCBI
Rnor_6.02181,045,694 - 181,103,321 (-)NCBI
Rnor_5.02200,453,480 - 200,515,219 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761107   ⟹   XP_008759329
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22167,418,615 - 167,482,293 (-)NCBI
Rnor_6.02181,045,694 - 181,074,131 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591011   ⟹   XP_017446500
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22167,418,615 - 167,481,222 (-)NCBI
Rnor_6.02181,045,694 - 181,103,321 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058786   ⟸   NM_017090
- UniProtKB: Q5U330 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232580   ⟸   XM_006232518
- Peptide Label: isoform X1
- UniProtKB: Q5U330 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759329   ⟸   XM_008761107
- Peptide Label: isoform X1
- UniProtKB: Q5U330 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446500   ⟸   XM_017591011
- Peptide Label: isoform X1
- UniProtKB: Q5U330 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017190   ⟸   ENSRNOT00000017190
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19686-F1-model_v2 AlphaFold P19686 1-690 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691392
Promoter ID:EPDNEW_R1917
Type:multiple initiation site
Name:Gucy1a3_1
Description:guanylate cyclase 1 soluble subunit alpha 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02181,102,872 - 181,102,932EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
2 173782485 173782486 G T snv FHL/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68436 AgrOrtholog
BioCyc Gene G2FUF-52683 BioCyc
Ensembl Genes ENSRNOG00000012302 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017190 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017190 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.1230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7190419 IMAGE-MGC_LOAD
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  H-NOX_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOB_dom_associated UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOB_dom_associated_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NO_sig/Golgi_transp_ligand-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:497757 UniProtKB/TrEMBL
MGC_CLONE MGC:93532 IMAGE-MGC_LOAD
NCBI Gene 497757 ENTREZGENE
Pfam Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gucy1a1 PhenoGen
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111126 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC230155
UniProt GCYA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5U330 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gucy1a3  guanylate cyclase 1, soluble, alpha 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs 3-(5-Hydroxymethyl-2-furyl)-1-benzyl indazole (YC1) decreases expression 628495
gene_expression expressed in lung and brain 61495
gene_expression expressed in lung and brain 68258
gene_function subunit of soluble guanylate cyclase, forms a heterodimer with Gucy1b3 that converts GTP to cGMP 61495
gene_function intracellular nitric oxide receptor in vascular smooth muscle cells 628495
gene_physical_interaction forms heterodimer with Gucy1b3 61495
gene_physical_interaction forms heterodimer with Gucy1b3 68258
gene_process may control salt-sensitive hypertension 61495
gene_process activates cGMP-dependent protein kinase that induces vascular smooth muscle relaxation and prevents contractile agonist-elicited intracellular free Ca2+ mobilization, dephosphorylates myosin light chain kinase 628495
gene_process hemoprotein mediating NO signaling by forming 3:5-cyclinc monophosphate (cGMP) 628495
gene_protein 76-81.5 kDa 628495
gene_regulation protected mRNA-stabilizing protein HuR which binds to the 3-UTR; increased Gucy1a3 levels results in downregulation of HuR expression and autoregulation as a negative feedback response 628495
gene_regulation mRNA and protein expression is decreased by beta-amyloid peptides in astroglial cells 1298937