Gucy1a1 (guanylate cyclase 1 soluble subunit alpha 1)

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Gene: Gucy1a1 (guanylate cyclase 1 soluble subunit alpha 1) Rattus norvegicus

Analyze

Symbol:

Gucy1a1

Name:

guanylate cyclase 1 soluble subunit alpha 1

RGD ID:

68436

Description:

Exhibits ion binding activity. Contributes to adenylate cyclase activity and cytidylate cyclase activity. Involved in response to herbicide and response to organic cyclic compound. Localizes to guanylate cyclase complex, soluble. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1); PARTICIPATES IN long term depression; purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

GCS-alpha-1; GCS-alpha-3; guanylate cyclase 1 soluble subunit alpha 3; guanylate cyclase 1, soluble, alpha 3; Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase); guanylate cyclase soluble subunit alpha-1; guanylate cyclase soluble subunit alpha-3; Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase); Gucy1a3; SGC; soluble guanylate cyclase; soluble guanylate cyclase large subunit

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Allele / Splice:

Gucy1a3^em1Mcwi

Genetic Models:

SS-Gucy1a3^em1Mcwi

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	167,418,615 - 167,482,293 (-)	NCBI
Rnor_6.0 Ensembl	2	181,045,703 - 181,102,918 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	2	181,045,694 - 181,103,321 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	200,453,480 - 200,515,219 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	173,756,824 - 173,818,316 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	173,705,122 - 173,768,506 (-)	NCBI
Celera	2	161,450,514 - 161,511,622 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenoid cystic carcinoma (ISO)

Colonic Neoplasms (ISO)

coronary artery disease (ISO)

hypertension (ISO)

Moyamoya disease (ISS)

Moyamoya Disease 1 (ISO)

Moyamoya Disease 6 with Achalasia (ISO)

myocardial infarction (ISO)

primary open angle glaucoma (ISS)

Pulmonary Edema of Mountaineers (ISO)

Salivary Gland Neoplasms (ISO)

thrombosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (EXP)

2-methylcholine (ISO)

3',5'-cyclic GMP (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

7H-xanthine (EXP)

9H-xanthine (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

apocynin (EXP)

atrazine (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

carbonyl sulfide (EXP)

chloroprene (EXP,ISO)

cinaciguat (EXP,ISO)

clobetasol (ISO)

cocaine (EXP)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

crocidolite asbestos (ISO)

cyanocob(III)alamin (ISO)

cyclosporin A (ISO)

cytarabine (ISO)

diethyl malate (ISO)

dioxygen (ISO)

disodium selenite (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (ISO)

fenvalerate (EXP)

ferroheme b (EXP)

folic acid (ISO)

formaldehyde (ISO)

glafenine (EXP)

GTP (ISO)

heme b (EXP)

hydrogen peroxide (EXP)

hydroxocobalamin (ISO)

isoflavones (EXP)

lead diacetate (EXP)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

menadione (EXP)

methylseleninic acid (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nickel atom (ISO)

nimesulide (EXP)

nitric oxide (ISO)

nitroglycerin (EXP)

nitroprusside (EXP)

NONOate(1-) (ISO)

oxaliplatin (EXP)

p-toluidine (EXP)

panobinostat (ISO)

paraquat (EXP)

pentachlorophenol (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

PhIP (EXP)

pioglitazone (ISO)

pirinixic acid (EXP,ISO)

potassium dichromate (ISO)

potassium hexacyanoferrate(3-) (ISO)

progesterone (EXP)

protoporphyrin (ISO)

S-nitrosoglutathione (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

Soman (EXP)

taurine (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

toluene (EXP)

topotecan (EXP)

tunicamycin (ISO)

valproic acid (EXP,ISO)

vancomycin (ISO)

vinclozolin (EXP)

zinc protoporphyrin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cGMP biosynthetic process (IEA,ISO)

intracellular signal transduction (IEA)

positive regulation of nitric oxide mediated signal transduction (IEA,ISO)

regulation of blood pressure (IEA,ISO)

relaxation of vascular associated smooth muscle (IEA,ISO)

response to herbicide (IEP)

response to organic cyclic compound (IEP)

retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission (IEA,ISO)

Cellular Component

cytosol (TAS)

GABA-ergic synapse (IEA,ISO)

glutamatergic synapse (IEA,ISO)

guanylate cyclase complex, soluble (IDA,IEA,ISO,TAS)

protein-containing complex (IDA)

synapse (ISO)

Molecular Function

adenylate cyclase activity (IDA)

cytidylate cyclase activity (IDA)

GTP binding (IEA)

guanylate cyclase activity (IEA,ISO,TAS)

heme binding (IEA)

ion binding (IDA)

protein binding (ISO)

protein-containing complex binding (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

long term depression (IEA)

purine metabolic pathway (IEA)

References

References - curated


1.	Almanza A, etal., J Neurophysiol. 2007 Feb;97(2):1188-95. Epub 2006 Dec 20.
2.	Azam M, etal., Hypertension 1998 Jul;32(1):149-54.
3.	Baltrons MA, etal., Neurobiol Dis 2002 Jul;10(2):139-49.
4.	Beste KY, etal., Biochemistry. 2012 Jan 10;51(1):194-204. doi: 10.1021/bi201259y. Epub 2011 Dec 13.
5.	GOA data from the GO Consortium
6.	KEGG
7.	Kloss S, etal., J Biol Chem 2003 Jan 24;278(4):2377-83.
8.	Legg RL, etal., Reprod Biol Endocrinol. 2008 Nov 24;6:57.
9.	MGD data from the GO Consortium
10.	Moran JM, etal., Nitric Oxide. 2010 Apr 11.
11.	Nakane M, etal., J Biol Chem 1990 Oct 5;265(28):16841-5.
12.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	Nedvetsky PI, etal., Brain Res 2002 Sep 20;950(1-2):148-54.
14.	OMIM Disease Annotation Pipeline
15.	Papapetropoulos A, etal., Mol Pharmacol. 2005 Oct;68(4):1133-41. Epub 2005 Jul 15.
16.	Pipeline to import KEGG annotations from KEGG into RGD
17.	RGD automated data pipeline
18.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.	RGD automated import pipeline for gene-chemical interactions
20.	Smigrodzki R and Levitt P, Brain Res Dev Brain Res 1996 Dec 23;97(2):226-34.
21.	Tao YX and Johns RA, Neuroscience 2002;112(2):439-46.
22.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23.	Winger JA, etal., J Biol Chem. 2007 Jan 12;282(2):897-907. Epub 2006 Nov 10.

Additional References at PubMed

PMID:12477932	PMID:14749300	PMID:14754757	PMID:16131543	PMID:16489110	PMID:16614755	PMID:17170090	PMID:18022154	PMID:18474600	PMID:18550612	PMID:18572161	PMID:18635821
PMID:19141686	PMID:19466990	PMID:20009348	PMID:20023176	PMID:20353168	PMID:20459051	PMID:22806360	PMID:23093402	PMID:23505436	PMID:24982890	PMID:27009048	PMID:27923787
PMID:28782641	PMID:30260287	PMID:32358060

Genomics

Comparative Map Data

Gucy1a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	167,418,615 - 167,482,293 (-)	NCBI
Rnor_6.0 Ensembl	2	181,045,703 - 181,102,918 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	2	181,045,694 - 181,103,321 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	200,453,480 - 200,515,219 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	173,756,824 - 173,818,316 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	173,705,122 - 173,768,506 (-)	NCBI
Celera	2	161,450,514 - 161,511,622 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

GUCY1A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	4	155,666,711 - 155,732,349 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	4	155,666,726 - 155,737,059 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	4	155,666,725 - 155,737,059 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	4	156,588,000 - 156,658,211 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	156,807,328 - 156,871,232 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	4	156,945,482 - 157,009,379	NCBI
Celera	4	153,919,477 - 153,989,823 (+)	NCBI
Cytogenetic Map	4	q32.1	NCBI
HuRef	4	152,327,271 - 152,397,264 (+)	NCBI		HuRef
CHM1_1	4	156,565,607 - 156,635,931 (+)	NCBI		CHM1_1

Gucy1a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	81,999,734 - 82,053,253 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	3	81,999,734 - 82,053,096 (-)	Ensembl
GRCm38	3	82,092,427 - 82,145,946 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	82,092,427 - 82,145,789 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	81,896,349 - 81,949,799 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	3	82,178,354 - 82,231,000 (-)	NCBI			mm8
Celera	3	82,117,270 - 82,170,809 (-)	NCBI		Celera
Cytogenetic Map	3	E3	NCBI

Gucy1a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955471	11,367,282 - 11,424,273 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955471	11,367,318 - 11,422,199 (-)	NCBI	ChiLan1.0	ChiLan1.0

GUCY1A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	4	159,850,092 - 159,920,159 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	159,850,107 - 159,913,338 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	4	148,032,167 - 148,102,757 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

GUCY1A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	53,172,914 - 53,236,200 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	53,174,157 - 53,234,533 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	53,510,720 - 53,570,219 (+)	NCBI
ROS_Cfam_1.0	15	53,880,516 - 53,943,086 (+)	NCBI
UMICH_Zoey_3.1	15	53,134,895 - 53,194,847 (+)	NCBI
UNSW_CanFamBas_1.0	15	53,244,742 - 53,304,495 (+)	NCBI
UU_Cfam_GSD_1.0	15	53,557,797 - 53,618,055 (+)	NCBI

Gucy1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	37,135,116 - 37,192,728 (-)	NCBI
SpeTri2.0	NW_004936576	2,353,874 - 2,411,747 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GUCY1A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	44,449,232 - 44,518,135 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	44,448,758 - 44,520,737 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	46,457,572 - 46,537,279 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GUCY1A1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	102,206,438 - 102,310,535 (+)	NCBI
ChlSab1.1 Ensembl	7	102,238,477 - 102,303,673 (+)	Ensembl

Gucy1a1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624848	2,522,935 - 2,588,758 (-)	NCBI

Position Markers

RH133297

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	2	181,045,757 - 181,045,937	NCBI	Rnor6.0
Rnor_5.0	2	200,453,543 - 200,453,723	UniSTS	Rnor5.0
RGSC_v3.4	2	173,755,055 - 173,755,235	UniSTS	RGSC3.4
Celera	2	161,448,745 - 161,448,925	UniSTS
RH 3.4 Map	2	1090.1	UniSTS
Cytogenetic Map	2	q33	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42776916	195645082	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	157914311	204022555	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	140566078	217498545	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	140566078	217498545	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	140566078	217498545	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	140566078	217498545	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	140566078	217498545	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	147522550	217498710	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46537589	217498710	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43133606	217498545	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43133606	217498545	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	149114878	225501939	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56244671	217498710	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42776916	217498710	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141583337	217498710	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66828049	217498710	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42776916	217498710	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147122993	240020001	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	147122993	240020001	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	142053350	204585731	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	157914409	217498545	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	116075644	228737869	Rat
631520	Bp73	Blood pressure QTL 73		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	153799203	181987474	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	169852800	217498545	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	155965557	254121739	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	155965557	237742948	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	161745602	206745602	Rat
2301415	Cm67	Cardiac mass QTL 67		0.003	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	172795683	189857032	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	116075644	228737869	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	175403337	239166203	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	118446646	227707979	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	138901276	217498710	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43149788	198704485	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	75687495	221880419	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	158159186	217498710	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83819608	239166203	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66828236	243550655	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83819608	243901375	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	158159186	217498710	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	142053350	228984665	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	118446793	228582621	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	177680772	243901375	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	23837491	218957222	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	23837491	218957222	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	118446646	200453484	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	118446646	200453484	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	169852670	207612467	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78321410	217498710	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	159585731	204585731	Rat
6903312	Bw112	Body weight QTL 112	3.2	0.0013	body mass (VT:0001259)	body weight (CMO:0000012)	2	149614623	198704357	Rat
6907363	Bp357	Blood pressure QTL 357	4.1	0.002	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	143447078	188447078	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	174160958	219160958	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	177339806	222339806	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	169852670	243026643	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83754907	237610852	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	149614466	205573168	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	149614466	205573168	Rat
12879846	Cm90	Cardiac mass QTL 90		0.011	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	2	172795683	189857032	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	172795683	199696953	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	16679272	245624402	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	172795683	199696953	Rat
11565181	Bw176	Body weight QTL 176		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	2	172795683	189857032	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	172795683	199696953	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	172795683	199696953	Rat
12879845	Cm89	Cardiac mass QTL 89		0.008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	172795683	189857032	Rat
11565180	Kidm56	Kidney mass QTL 56		0.003	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	172795683	189857032	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	172795683	199696953	Rat
12879847	Am4	Aortic mass QTL 4		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	172795683	189857032	Rat

Genetic Models

This gene Gucy1a1 is modified in the following models/strains

SS-Gucy1a3^em1Mcwi

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	550
Count of miRNA genes:	260
Interacting mature miRNAs:	337
Transcripts:	ENSRNOT00000017190
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	37	30	14	19	14	2	2	62	33	31	11	2
Low	1	6	27	27		27	6	9	12	2	10		6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761107	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB096020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224100	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M57405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U60835	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000017190 ⟹ ENSRNOP00000017190

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	181,045,703 - 181,102,918 (-)	Ensembl

RefSeq Acc Id:

NM_017090 ⟹ NP_058786

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	167,420,447 - 167,481,557 (-)	NCBI
Rnor_6.0	2	181,047,526 - 181,102,793 (-)	NCBI
Rnor_5.0	2	200,453,480 - 200,515,219 (-)	NCBI
RGSC_v3.4	2	173,756,824 - 173,818,316 (-)	RGD
Celera	2	161,450,514 - 161,511,622 (-)	RGD

Sequence:

show sequence

CGGATGCCCCTGGCCTCCCGTGACCGCATCATGATGCTGGGCCACTCGTGTCTTTGAGTCAGTA
GAAGCAGATCTTCATCAGTCCACATCAACACCGGCTAATAAGGAGGAAACCACTGCCAAGCTCC
AGGAACACCATGTTCTGCAGGAAGTTCAAAGATCTCAAGATCACGGGGGAGTGTCCTTTCTCCT
TACTGGCTCCTGGTCAGGTTCCTACGGAGCCAATAGAGGAGGTGGCCGGAGTCTCTGAGAGCTG
CCAGGCCACTCTGCCCACCTGCCAGGAGTTTGCTGAGAATGCAGAAGGGAGTCACCCCCAAAGA
AAGACAAGCCGCAACAGAGTCTACCTACACACCCTGGCAGAGAGTATTGGCAAGCTCATTTTCC
CAGAGTTTGAGAGACTGAACCTTGCACTTCAGAGAACATTGGCAAAGCACAAAATAAAGGAAAA
CAGGAATTCTTCAGAAAAAGAAGACCTTGAAAGAATAATTGCAGAAGAAGCAATTGCGGCAGGT
GTCCCAGTGGAGGCGCTCAAAGACTCTCTGGGTGAGGAACTGTTCAAGATCTGTTATGAGGAAG
ATGAGCACATCCTGGGCGTGGTTGGCGGCACCCTGAAGGACTTTCTCAACAGCTTCAGCACGCT
CCTGAAGCAGAGCAGCCACTGCCAGGAGGCGGAGAGGCGGGGGCGACTGGAAGATGCCTCCATC
TTGTGCCTGGACAAGGACCAGGACTTTCTAAATGTTTACTACTTCTTCCCGAAGAGAACCACAG
CCCTGCTTCTCCCCGGTATCATTAAAGCGGCTGCTCGCATACTGTACGAAAGCCACGTGGAGGT
GTCCCTGATGCCTCCCTGCTTCCGAAGTGAGTGTACCGAATTCGTGAACCAGCCCTATTTGCTC
TACTCGGTCCACGTGAAGAGCACCAAGCCTTCTCTGTCCCCAGGCAAACCCCAGTCCTCGCTAG
TGATCCCTACTTCGCTCTTCTGCAAAACTTTCCCATTCCACTTCATGCTGGACCGTGACCTGGC
CATTCTGCAGCTGGGTAATGGCATCAGAAGGCTGGTGAACAAGAGGGACTTCCAAGGGAAGCCC
AACTTTGAAGAGTTCTTTGAAATTCTAACTCCCAAAATCAACCAGACATTTAGCGGCATCATGA
CAATGTTGAATATGCAGTTTGTCATACGGGTGAGGAGATGGGATAACTTAGTGAAGAAATCTTC
AAGGGTTATGGACCTCAAAGGTCAAATGATCTACATCGTTGAATCCAGTGCCATCTTGTTCTTA
GGGTCGCCGTGTGTGGACAGATTGGAAGATTTCACAGGACGGGGTCTCTATCTGTCTGACATCC
CGATTCATAATGCCCTGAGGGATGTTGTCTTGATAGGGGAACAGGCACGGGCTCAAGATGGCCT
CAAGAAGAGGTTGGGAAAGCTGAAGGCAACCTTGGAGCATGCCCACCAAGCCCTGGAGGAGGAG
AAGAAGAAGACGGTAGATCTCCTGTGTTCTATCTTTCCCTCTGAGGTTGCTCAGCAGCTCTGGC
AAGGACAAATTGTGCAAGCCAAGAAGTTCAATGAGGTCACCATGCTCTTCTCAGATATCGTAGG
GTTCACTGCCATCTGCTCTCAGTGTTCACCTCTGCAGGTCATCACCATGCTCAACGCTCTCTAT
ACTCGCTTTGACCAACAGTGTGGAGAGCTGGATGTCTACAAGGTGGAGACCATCGGAGATGCAT
ATTGTGTGGCAGGGGGATTGCACAGAGAGAGTGACACACATGCTGTCCAGATAGCACTGATGGC
CCTGAAGATGATGGAGCTCTCCAATGAGGTCATGTCTCCCCACGGAGAACCTATCAAGATGCGA
ATCGGACTGCATTCTGGGTCAGTGTTTGCTGGAGTTGTTGGAGTGAAGATGCCCCGATATTGCC
TGTTTGGAAACAATGTCACTCTGGCTAACAAATTTGAGTCCTGCAGTGTGCCTCGGAAAATCAA
TGTCAGCCCCACGACATACAGGTTACTCAAAGACTGTCCTGGCTTTGTGTTCACCCCGAGATCG
AGGGAGGAGCTTCCACCAAACTTCCCTAGTGACATTCCTGGAATCTGTCACTTTCTGGATGCTT
ATCAACATCAAGGACCTAATTCTAAACCATGGTTCCAGCAGAAAGATGCAGAAGATGGAAACGC
TAACTTCTTAGGCAAAGCATCAGGGGTAGATTAGTGAGCCGCATGTTTCTGTGTTTGATGCCTT
TGAGGGTGCGCAGAATCTCTGAAATGACTTTAGGATTGCAGAAGATAAAAAACTGTGTTAAAAT
TGCAGGGGTGAAACCCAGTTTCCTCTGTTTCCCATTTAAGATGGAAAAAAAAAAGTGTTCAATG
CTTCAGCGCTTTCAACCTTCTTCTCTATTTAAGAAACAAACCTCAAAAGTGACTTGTGACTTTT
GGGGACATAGCTTTGTTCTAGAGCAGTCACTACCTGCACTCGAAATCCAACACAGTGTACATAT
TCCAGACAATTGTAGTCAAGTTTAAGTGTCAAAGTAATGTACTCACCTGTGGCCTGTGACCAGT
GCAAACTGTGGTTATTACAGTGTGTCTGTGGTAGTGTTGCCTGTAAATCTCTGAATAGAAATGA
CAGTGTTTAATTCTGAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006232518 ⟹ XP_006232580

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	167,418,615 - 167,482,293 (-)	NCBI
Rnor_6.0	2	181,045,694 - 181,103,321 (-)	NCBI
Rnor_5.0	2	200,453,480 - 200,515,219 (-)	NCBI

Sequence:

show sequence

GTATTAACAGCATATAGGGCTGAGTGTAGTGAACCAAATAGAAGCAAGACCTTACACAAAAGAA
ATAATATTTCTGTGACCACAAAATTACCTTCGAACAGAGTAGATTAGCCTCAAAGCTAAAAGCC
AGGCCACCAAAGCCAAGGGAGGAGAGAAAAACCTCCCCACCACGGTTTGAGTTTCAAATTAAGG
AAGCTACAGTTGGTCTGCACCAGCTAGTACGAGAGAAAAGGTTTTTGTTTTTAACGTGCCAACT
TTTCCTAGAGTCTCTCCTTTGTTTTCTCTTCCTTGTCCCCTTCCCTGCTGTGTGTGTGTCTGGC
TTTGGTGGTTTGGAGGACAGCGATTGGGCGGGGAGCAGGACTCCGTTCTCAGGAGCTGAGCCTG
GGAGGAGTGGGAGGGACTCGGAGCAGCGGGGTTCTCACACACAGCCTTCCAGGCGGTCCTTCTC
CAGTGCCTGCCAGCTCGACCCCAAGGCGAAGAGCAGCAGTGCTCAGCCCGGGGAGTCCTCGAAG
CGAAGACACCTGCGCCCGGATGCCCCTGGCCTCCCGTGACCGCATCATGCATACCTCCCCTCTT
CCCAGCCAGCTCTATACCAACCTCAGAAGTGACCACACTGTTTCTAAAATGCTGGGCCACTCGT
GTCTTTGAGTCAGTAGAAGCAGATCTTCATCAGTCCACATCAACACCGGCTAATAAGGAGGAAA
CCACTGCCAAGCTCCAGGAACACCATGTTCTGCAGGAAGTTCAAAGATCTCAAGATCACGGGGG
AGTGTCCTTTCTCCTTACTGGCTCCTGGTCAGGTTCCTACGGAGCCAATAGAGGAGGTGGCCGG
AGTCTCTGAGAGCTGCCAGGCCACTCTGCCCACCTGCCAGGAGTTTGCTGAGAATGCAGAAGGG
AGTCACCCCCAAAGAAAGACAAGCCGCAACAGAGTCTACCTACACACCCTGGCAGAGAGTATTG
GCAAGCTCATTTTCCCAGAGTTTGAGAGACTGAACCTTGCACTTCAGAGAACATTGGCAAAGCA
CAAAATAAAGGAAAACAGGAATTCTTCAGAAAAAGAAGACCTTGAAAGAATAATTGCAGAAGAA
GCAATTGCGGCAGGTGTCCCAGTGGAGGCGCTCAAAGACTCTCTGGGTGAGGAACTGTTCAAGA
TCTGTTATGAGGAAGATGAGCACATCCTGGGCGTGGTTGGCGGCACCCTGAAGGACTTTCTCAA
CAGCTTCAGCACGCTCCTGAAGCAGAGCAGCCACTGCCAGGAGGCGGAGAGGCGGGGGCGACTG
GAAGATGCCTCCATCTTGTGCCTGGACAAGGACCAGGACTTTCTAAATGTTTACTACTTCTTCC
CGAAGAGAACCACAGCCCTGCTTCTCCCCGGTATCATTAAAGCGGCTGCTCGCATACTGTACGA
AAGCCACGTGGAGGTGTCCCTGATGCCTCCCTGCTTCCGAAGTGAGTGTACCGAATTCGTGAAC
CAGCCCTATTTGCTCTACTCGGTCCACGTGAAGAGCACCAAGCCTTCTCTGTCCCCAGGCAAAC
CCCAGTCCTCGCTAGTGATCCCTACTTCGCTCTTCTGCAAAACTTTCCCATTCCACTTCATGCT
GGACCGTGACCTGGCCATTCTGCAGCTGGGTAATGGCATCAGAAGGCTGGTGAACAAGAGGGAC
TTCCAAGGGAAGCCCAACTTTGAAGAGTTCTTTGAAATTCTAACTCCCAAAATCAACCAGACAT
TTAGCGGCATCATGACAATGTTGAATATGCAGTTTGTCATACGGGTGAGGAGATGGGATAACTT
AGTGAAGAAATCTTCAAGGGTTATGGACCTCAAAGGTCAAATGATCTACATCGTTGAATCCAGT
GCCATCTTGTTCTTAGGGTCGCCGTGTGTGGACAGATTGGAAGATTTCACAGGACGGGGTCTCT
ATCTGTCTGACATCCCGATTCATAATGCCCTGAGGGATGTTGTCTTGATAGGGGAACAGGCACG
GGCTCAAGATGGCCTCAAGAAGAGGTTGGGAAAGCTGAAGGCAACCTTGGAGCATGCCCACCAA
GCCCTGGAGGAGGAGAAGAAGAAGACGGTAGATCTCCTGTGTTCTATCTTTCCCTCTGAGGTTG
CTCAGCAGCTCTGGCAAGGACAAATTGTGCAAGCCAAGAAGTTCAATGAGGTCACCATGCTCTT
CTCAGATATCGTAGGGTTCACTGCCATCTGCTCTCAGTGTTCACCTCTGCAGGTCATCACCATG
CTCAACGCTCTCTATACTCGCTTTGACCAACAGTGTGGAGAGCTGGATGTCTACAAGGTGGAGA
CCATCGGAGATGCATATTGTGTGGCAGGGGGATTGCACAGAGAGAGTGACACACATGCTGTCCA
GATAGCACTGATGGCCCTGAAGATGATGGAGCTCTCCAATGAGGTCATGTCTCCCCACGGAGAA
CCTATCAAGATGCGAATCGGACTGCATTCTGGGTCAGTGTTTGCTGGAGTTGTTGGAGTGAAGA
TGCCCCGATATTGCCTGTTTGGAAACAATGTCACTCTGGCTAACAAATTTGAGTCCTGCAGTGT
GCCTCGGAAAATCAATGTCAGCCCCACGACATACAGGTTACTCAAAGACTGTCCTGGCTTTGTG
TTCACCCCGAGATCGAGGGAGGAGCTTCCACCAAACTTCCCTAGTGACATTCCTGGAATCTGTC
ACTTTCTGGATGCTTATCAACATCAAGGACCTAATTCTAAACCATGGTTCCAGCAGAAAGATGC
AGAAGATGGAAACGCTAACTTCTTAGGCAAAGCATCAGGGGTAGATTAGTGAGCCGCATGTTTC
TGTGTTTGATGCCTTTGAGGGTGCGCAGAATCTCTGAAATGACTTTAGGATTGCAGAAGATAAA
AAACTGTGTTAAAATTGCAGGGGTGAAACCCAGTTTCCTCTGTTTCCCATTTAAGATGGAAAAA
AAAAAGTGTTCAATGCTTCAGCGCTTTCAACCTTCTTCTCTATTTAAGAAACAAACCTCAAAAG
TGACTTGTGACTTTTGGGGACATAGCTTTGTTCTAGAGCAGTCACTACCTGCACTCGAAATCCA
ACACAGTGTACATATTCCAGACAATTGTAGTCAAGTTTAAGTGTCAAAGTAATGTACTCACCTG
TGGCCTGTGACCAGTGCAAACTGTGGTTATTACAGTGTGTCTGTGGTAGTGTTGCCTGTAAATC
TCTGAATAGAAATGACAGTGTTTAATTCTGCAAGAGCTTCCAGCCTCTTGACTCTACATTCAAT
TAGGTTTCCTTATTCTATCCTGGCGTATGTAACACAATAGGCCAGCGCCTTCTTCCCAGCTACA
TCTTTGTGCCTATGTACGTGTTTTCCTTTCCTTTCCTTTCCTTTCCTTTTTTTTTTTTAAGAAA
ATAAGCAATTAGACATAGGATAAAATGTGATATAAAGTAGTTCAGTAAGTGTCAAAGAATATTT
TCATGTTTTGTCATTAAAGATATTATCTATAGCACAATATATAATACAACAAATACTTTTCATT
TTGATCCTATCTGTGATAAAACATTTTAATTAATAGTAACAATGTACTTCCTACTAATCCATGT
AAAATTTACTAATAGCAAAACTTTCAGAGTAAAAGTATTTACATACATTGTTAAAATGCAATAA
CATTCAAATTTAATTAAGGCATAGAATTAATATTTGCACACAGAGAGCCTACTGTAGAGGACAG
TGGCAAAGTGTTCACAAACACACGTGTTTAAATGATCCTCTACTGCCGTGTTGAGCCATAAAAG
CCAAGGGGAAAAGTTTTAAGTCAGAAGTAGAAAAATAGACTTCATTTTGTCTTTTTTGATACCT
TCTTAAGTATTTCTACTGACCATTTAGTGTATGTGTATGTGTTAAGAATCAAAATTTTTATTAC
TCAGTGTACACCTGTGAAGTATTATTCTACTTTAAATATACTAATATTTTCTACAGAAACCACT
AGTATCATTGAAGAAAATGTCACTATGATTTCATTATAGAGATCCTGATACGTTTTTTTTTCTT
CTGGAGTTTAAACTAATGTCCTTTCCTTCCCCTGCCCTCCTCTGCAGTCCTCTTTCTTCCTCTC
CCATTGGGCATGTTTGTGTGATTCTGTGGGCTGAACACAGGAACTGTGCATGCTGGGTAAAGAC
TGTTACTGAGTAACTTCCTCACCATGGGGCTTCAGTTTTATTGCTAATGGTGACAGTTTACATT
CCCGAGTGTTAATTTGGTAAAAGGAAGTGACTTTAAAAGAAGACCAACTTCAAAGCCAAGAGAG
ATAGACATAATTGAATTTTTCAATCAGTATTAGTAGAATGGTAGACATTCTGAATTTCTATGTG
TGTAGTTGAAAAGAAACTCAGTTTAAAAGTCATTTTCTACCTCCAATAGTCTTCAAGCATCCAG
AGCAACAGACATCTTTTACCTAGCTCTAGTTTCCAAGGGGGACAACTAAACCACCCAATGGATT
TCTTTAAAGGCGGATATTGTCTCATTAAACAGTCACACTGATGTTGGATAGTGTCACGGGCCTT
GCAAAGGTGTATTTAGGATGTCACAATGATGTGGAATTCAATGAATATTTATTAAGAAGGTAAA
GAGGTAAATACCCCCTCTTTCTGGAACTAATATTCAATACAGGGGAACTAGTAGGAATCACAGA
CAATTAGAAAGCGTAAAACAGGATGTCATCCTCTTAAGCTGTGCAGTTAGGTGGTTGCTACATT
AGTAATAATCTGATTCAGAAGCTTGCACATTAATTAGAATTAATTCTCCCACTGTCTTTTAGGG
ATGGTGATAGAACTCAATGACAAAGCACCTGCCTAGCATTTAGGCAGTCCTGTTCCGACCCAAG
CAGCATGAAGGAATTACATGTATCTCTCATGTGCATATGATGTATGATCACACTCACCTGTGTC
ACCTGTGTACACACCTGGGGCAAATGGAGGAACTGTATCTAATTCAAGGCAAACTACCGGAGCT
CCATGTACGGTTCCTATAACTTTTCTATTATTTTGTCATTTTAGCTAAATAAAAACATTATCAA
AAATTA

hide sequence

RefSeq Acc Id:

XM_008761107 ⟹ XP_008759329

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	167,418,615 - 167,482,293 (-)	NCBI
Rnor_6.0	2	181,045,694 - 181,074,131 (-)	NCBI

Sequence:

show sequence

AGAAAACATTTCAAAAAGAAACAAAGAAAGGAAGCCAGTCCTCAATGAATCCCCAAATTCTAAG
CATTGCTTCTCAGTCAGTAGAATTCTTGTGGGAAAGGTCACAAGTGCTGTGCTTATAGAGATGT
ATTTTACAAAGGAGTCTCCTGGAGGTAACTATACCTAAAGCTTTGTTGTGGTAATTGTCATTCG
AAAAGCTTTTCCCAAAGATTTAGTGTATTTAAATGTGTAACAAATAAATCTCTTGGGGTCAGAC
TCCATCAGTTTTGGCCCAGTGTTGGCTAACTAAGGTGTAGCTGAACCCAAGTTTCATTCTTACC
TCACTCAGATAGTTTCTCAATATATATAGAATAACACATAAAGTATTAAGGGGAGCACTGGCAT
GTACTGTTCTGATGTGTAGACAGGACACACATGAAATACAGTAGTTCTCGCATTAATGAAGCAA
TAATGAAGATCGTTCCTATGAAATCAAACAGAAACAAATGGGGTGCAGAAGGTGGAAATTGGTA
GTTTTTGCTAAGGATGTTTAGAGAAAATAATATTTGATACTCTGGTGGCAATTTCCCTGTGGAT
GATTGTACTACCTTTTTCTTTGTGCATCTAGCTATCTGTTGTGTGTCCTTTCTCTTCTGACTTT
CCACTGCTCATAGATGCTGGGCCACTCGTGTCTTTGAGTCAGTAGAAGCAGATCTTCATCAGTC
CACATCAACACCGGCTAATAAGGAGGAAACCACTGCCAAGCTCCAGGAACACCATGTTCTGCAG
GAAGTTCAAAGATCTCAAGATCACGGGGGAGTGTCCTTTCTCCTTACTGGCTCCTGGTCAGGTT
CCTACGGAGCCAATAGAGGAGGTGGCCGGAGTCTCTGAGAGCTGCCAGGCCACTCTGCCCACCT
GCCAGGAGTTTGCTGAGAATGCAGAAGGGAGTCACCCCCAAAGAAAGACAAGCCGCAACAGAGT
CTACCTACACACCCTGGCAGAGAGTATTGGCAAGCTCATTTTCCCAGAGTTTGAGAGACTGAAC
CTTGCACTTCAGAGAACATTGGCAAAGCACAAAATAAAGGAAAACAGGAATTCTTCAGAAAAAG
AAGACCTTGAAAGAATAATTGCAGAAGAAGCAATTGCGGCAGGTGTCCCAGTGGAGGCGCTCAA
AGACTCTCTGGGTGAGGAACTGTTCAAGATCTGTTATGAGGAAGATGAGCACATCCTGGGCGTG
GTTGGCGGCACCCTGAAGGACTTTCTCAACAGCTTCAGCACGCTCCTGAAGCAGAGCAGCCACT
GCCAGGAGGCGGAGAGGCGGGGGCGACTGGAAGATGCCTCCATCTTGTGCCTGGACAAGGACCA
GGACTTTCTAAATGTTTACTACTTCTTCCCGAAGAGAACCACAGCCCTGCTTCTCCCCGGTATC
ATTAAAGCGGCTGCTCGCATACTGTACGAAAGCCACGTGGAGGTGTCCCTGATGCCTCCCTGCT
TCCGAAGTGAGTGTACCGAATTCGTGAACCAGCCCTATTTGCTCTACTCGGTCCACGTGAAGAG
CACCAAGCCTTCTCTGTCCCCAGGCAAACCCCAGTCCTCGCTAGTGATCCCTACTTCGCTCTTC
TGCAAAACTTTCCCATTCCACTTCATGCTGGACCGTGACCTGGCCATTCTGCAGCTGGGTAATG
GCATCAGAAGGCTGGTGAACAAGAGGGACTTCCAAGGGAAGCCCAACTTTGAAGAGTTCTTTGA
AATTCTAACTCCCAAAATCAACCAGACATTTAGCGGCATCATGACAATGTTGAATATGCAGTTT
GTCATACGGGTGAGGAGATGGGATAACTTAGTGAAGAAATCTTCAAGGGTTATGGACCTCAAAG
GTCAAATGATCTACATCGTTGAATCCAGTGCCATCTTGTTCTTAGGGTCGCCGTGTGTGGACAG
ATTGGAAGATTTCACAGGACGGGGTCTCTATCTGTCTGACATCCCGATTCATAATGCCCTGAGG
GATGTTGTCTTGATAGGGGAACAGGCACGGGCTCAAGATGGCCTCAAGAAGAGGTTGGGAAAGC
TGAAGGCAACCTTGGAGCATGCCCACCAAGCCCTGGAGGAGGAGAAGAAGAAGACGGTAGATCT
CCTGTGTTCTATCTTTCCCTCTGAGGTTGCTCAGCAGCTCTGGCAAGGACAAATTGTGCAAGCC
AAGAAGTTCAATGAGGTCACCATGCTCTTCTCAGATATCGTAGGGTTCACTGCCATCTGCTCTC
AGTGTTCACCTCTGCAGGTCATCACCATGCTCAACGCTCTCTATACTCGCTTTGACCAACAGTG
TGGAGAGCTGGATGTCTACAAGGTGGAGACCATCGGAGATGCATATTGTGTGGCAGGGGGATTG
CACAGAGAGAGTGACACACATGCTGTCCAGATAGCACTGATGGCCCTGAAGATGATGGAGCTCT
CCAATGAGGTCATGTCTCCCCACGGAGAACCTATCAAGATGCGAATCGGACTGCATTCTGGGTC
AGTGTTTGCTGGAGTTGTTGGAGTGAAGATGCCCCGATATTGCCTGTTTGGAAACAATGTCACT
CTGGCTAACAAATTTGAGTCCTGCAGTGTGCCTCGGAAAATCAATGTCAGCCCCACGACATACA
GGTTACTCAAAGACTGTCCTGGCTTTGTGTTCACCCCGAGATCGAGGGAGGAGCTTCCACCAAA
CTTCCCTAGTGACATTCCTGGAATCTGTCACTTTCTGGATGCTTATCAACATCAAGGACCTAAT
TCTAAACCATGGTTCCAGCAGAAAGATGCAGAAGATGGAAACGCTAACTTCTTAGGCAAAGCAT
CAGGGGTAGATTAGTGAGCCGCATGTTTCTGTGTTTGATGCCTTTGAGGGTGCGCAGAATCTCT
GAAATGACTTTAGGATTGCAGAAGATAAAAAACTGTGTTAAAATTGCAGGGGTGAAACCCAGTT
TCCTCTGTTTCCCATTTAAGATGGAAAAAAAAAAGTGTTCAATGCTTCAGCGCTTTCAACCTTC
TTCTCTATTTAAGAAACAAACCTCAAAAGTGACTTGTGACTTTTGGGGACATAGCTTTGTTCTA
GAGCAGTCACTACCTGCACTCGAAATCCAACACAGTGTACATATTCCAGACAATTGTAGTCAAG
TTTAAGTGTCAAAGTAATGTACTCACCTGTGGCCTGTGACCAGTGCAAACTGTGGTTATTACAG
TGTGTCTGTGGTAGTGTTGCCTGTAAATCTCTGAATAGAAATGACAGTGTTTAATTCTGCAAGA
GCTTCCAGCCTCTTGACTCTACATTCAATTAGGTTTCCTTATTCTATCCTGGCGTATGTAACAC
AATAGGCCAGCGCCTTCTTCCCAGCTACATCTTTGTGCCTATGTACGTGTTTTCCTTTCCTTTC
CTTTCCTTTCCTTTTTTTTTTTTAAGAAAATAAGCAATTAGACATAGGATAAAATGTGATATAA
AGTAGTTCAGTAAGTGTCAAAGAATATTTTCATGTTTTGTCATTAAAGATATTATCTATAGCAC
AATATATAATACAACAAATACTTTTCATTTTGATCCTATCTGTGATAAAACATTTTAATTAATA
GTAACAATGTACTTCCTACTAATCCATGTAAAATTTACTAATAGCAAAACTTTCAGAGTAAAAG
TATTTACATACATTGTTAAAATGCAATAACATTCAAATTTAATTAAGGCATAGAATTAATATTT
GCACACAGAGAGCCTACTGTAGAGGACAGTGGCAAAGTGTTCACAAACACACGTGTTTAAATGA
TCCTCTACTGCCGTGTTGAGCCATAAAAGCCAAGGGGAAAAGTTTTAAGTCAGAAGTAGAAAAA
TAGACTTCATTTTGTCTTTTTTGATACCTTCTTAAGTATTTCTACTGACCATTTAGTGTATGTG
TATGTGTTAAGAATCAAAATTTTTATTACTCAGTGTACACCTGTGAAGTATTATTCTACTTTAA
ATATACTAATATTTTCTACAGAAACCACTAGTATCATTGAAGAAAATGTCACTATGATTTCATT
ATAGAGATCCTGATACGTTTTTTTTTCTTCTGGAGTTTAAACTAATGTCCTTTCCTTCCCCTGC
CCTCCTCTGCAGTCCTCTTTCTTCCTCTCCCATTGGGCATGTTTGTGTGATTCTGTGGGCTGAA
CACAGGAACTGTGCATGCTGGGTAAAGACTGTTACTGAGTAACTTCCTCACCATGGGGCTTCAG
TTTTATTGCTAATGGTGACAGTTTACATTCCCGAGTGTTAATTTGGTAAAAGGAAGTGACTTTA
AAAGAAGACCAACTTCAAAGCCAAGAGAGATAGACATAATTGAATTTTTCAATCAGTATTAGTA
GAATGGTAGACATTCTGAATTTCTATGTGTGTAGTTGAAAAGAAACTCAGTTTAAAAGTCATTT
TCTACCTCCAATAGTCTTCAAGCATCCAGAGCAACAGACATCTTTTACCTAGCTCTAGTTTCCA
AGGGGGACAACTAAACCACCCAATGGATTTCTTTAAAGGCGGATATTGTCTCATTAAACAGTCA
CACTGATGTTGGATAGTGTCACGGGCCTTGCAAAGGTGTATTTAGGATGTCACAATGATGTGGA
ATTCAATGAATATTTATTAAGAAGGTAAAGAGGTAAATACCCCCTCTTTCTGGAACTAATATTC
AATACAGGGGAACTAGTAGGAATCACAGACAATTAGAAAGCGTAAAACAGGATGTCATCCTCTT
AAGCTGTGCAGTTAGGTGGTTGCTACATTAGTAATAATCTGATTCAGAAGCTTGCACATTAATT
AGAATTAATTCTCCCACTGTCTTTTAGGGATGGTGATAGAACTCAATGACAAAGCACCTGCCTA
GCATTTAGGCAGTCCTGTTCCGACCCAAGCAGCATGAAGGAATTACATGTATCTCTCATGTGCA
TATGATGTATGATCACACTCACCTGTGTCACCTGTGTACACACCTGGGGCAAATGGAGGAACTG
TATCTAATTCAAGGCAAACTACCGGAGCTCCATGTACGGTTCCTATAACTTTTCTATTATTTTG
TCATTTTAGCTAAATAAAAACATTATCAAAAATTA

hide sequence

RefSeq Acc Id:

XM_017591011 ⟹ XP_017446500

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	167,418,615 - 167,481,222 (-)	NCBI
Rnor_6.0	2	181,045,694 - 181,103,321 (-)	NCBI

Sequence:

show sequence

GTATTAACAGCATATAGGGCTGAGTGTAGTGAACCAAATAGAAGCAAGACCTTACACAAAAGAA
ATAATATTTCTGTGACCACAAAATTACCTTCGAACAGAGTAGATTAGCCTCAAAGCTAAAAGCC
AGGCCACCAAAGCCAAGGGAGGAGAGAAAAACCTCCCCACCACGGTTTGAGTTTCAAATTAAGG
AAGCTACAGTTGGTCTGCACCAGCTAGTACGAGAGAAAAGGTTTTTGTTTTTAACGTGCCAACT
TTTCCTAGAGTCTCTCCTTTGTTTTCTCTTCCTTGTCCCCTTCCCTGCTGTGTGTGTGTCTGGC
TTTGGTGGTTTGGAGGACAGCGATTGGGCGGGGAGCAGGACTCCGTTCTCAGGAGCTGAGCCTG
GGAGGAGTGGGAGGGACTCGGAGCAGCGGGGTTCTCACACACAGCCTTCCAGGCGGTCCTTCTC
CAGTGCCTGCCAGCTCGACCCCAAGGCGAAGAGCAGCAGTGCTCAGCCCGGGGAGTCCTCGAAG
CGAAGACACCTGCGCCCGGATGCCCCTGGCCTCCCGTGACCGCATCATGGTGGGTTTGCTCAGC
TGCTTGCTTTTCTACTGTTCGGGGACTGGAGAAGGGGGTAAGGCATGCATGGCACGGAGACGTG
GAAAGAGGTCCTGTGTGGTAGAGAAGAGACAGGCAAGAATTCTTTGGGTCATGGCAGGGAAAAA
CAAAGGCGAGAAGTGGCTGTTTGCAGCATGGTGGGAACCGGCTCTGGGAATGTTCCGTGGGTTC
AGCCGCGCCCCTGGCTCTGGTTGACCAGGGTGTGCGCGGCGTGGCCTTGACTGCCCTGGGTGAA
TCCGCTCCGGACCGACAGGTGCGACTCCAGCGTCACCTCTCGGTCCATGCCAGCGCCGCCGCCC
TTCCTCTGTGATCCAGTGGGGTTGTTCTCTGCGGGGTGTTCTTGGCAGCTCCAGGAGGTCGGGA
ACCGCTGTCCCCAGGTCTGGAAGCCTCTGAATGCTGGGCCACTCGTGTCTTTGAGTCAGTAGAA
GCAGATCTTCATCAGTCCACATCAACACCGGCTAATAAGGAGGAAACCACTGCCAAGCTCCAGG
AACACCATGTTCTGCAGGAAGTTCAAAGATCTCAAGATCACGGGGGAGTGTCCTTTCTCCTTAC
TGGCTCCTGGTCAGGTTCCTACGGAGCCAATAGAGGAGGTGGCCGGAGTCTCTGAGAGCTGCCA
GGCCACTCTGCCCACCTGCCAGGAGTTTGCTGAGAATGCAGAAGGGAGTCACCCCCAAAGAAAG
ACAAGCCGCAACAGAGTCTACCTACACACCCTGGCAGAGAGTATTGGCAAGCTCATTTTCCCAG
AGTTTGAGAGACTGAACCTTGCACTTCAGAGAACATTGGCAAAGCACAAAATAAAGGAAAACAG
GAATTCTTCAGAAAAAGAAGACCTTGAAAGAATAATTGCAGAAGAAGCAATTGCGGCAGGTGTC
CCAGTGGAGGCGCTCAAAGACTCTCTGGGTGAGGAACTGTTCAAGATCTGTTATGAGGAAGATG
AGCACATCCTGGGCGTGGTTGGCGGCACCCTGAAGGACTTTCTCAACAGCTTCAGCACGCTCCT
GAAGCAGAGCAGCCACTGCCAGGAGGCGGAGAGGCGGGGGCGACTGGAAGATGCCTCCATCTTG
TGCCTGGACAAGGACCAGGACTTTCTAAATGTTTACTACTTCTTCCCGAAGAGAACCACAGCCC
TGCTTCTCCCCGGTATCATTAAAGCGGCTGCTCGCATACTGTACGAAAGCCACGTGGAGGTGTC
CCTGATGCCTCCCTGCTTCCGAAGTGAGTGTACCGAATTCGTGAACCAGCCCTATTTGCTCTAC
TCGGTCCACGTGAAGAGCACCAAGCCTTCTCTGTCCCCAGGCAAACCCCAGTCCTCGCTAGTGA
TCCCTACTTCGCTCTTCTGCAAAACTTTCCCATTCCACTTCATGCTGGACCGTGACCTGGCCAT
TCTGCAGCTGGGTAATGGCATCAGAAGGCTGGTGAACAAGAGGGACTTCCAAGGGAAGCCCAAC
TTTGAAGAGTTCTTTGAAATTCTAACTCCCAAAATCAACCAGACATTTAGCGGCATCATGACAA
TGTTGAATATGCAGTTTGTCATACGGGTGAGGAGATGGGATAACTTAGTGAAGAAATCTTCAAG
GGTTATGGACCTCAAAGGTCAAATGATCTACATCGTTGAATCCAGTGCCATCTTGTTCTTAGGG
TCGCCGTGTGTGGACAGATTGGAAGATTTCACAGGACGGGGTCTCTATCTGTCTGACATCCCGA
TTCATAATGCCCTGAGGGATGTTGTCTTGATAGGGGAACAGGCACGGGCTCAAGATGGCCTCAA
GAAGAGGTTGGGAAAGCTGAAGGCAACCTTGGAGCATGCCCACCAAGCCCTGGAGGAGGAGAAG
AAGAAGACGGTAGATCTCCTGTGTTCTATCTTTCCCTCTGAGGTTGCTCAGCAGCTCTGGCAAG
GACAAATTGTGCAAGCCAAGAAGTTCAATGAGGTCACCATGCTCTTCTCAGATATCGTAGGGTT
CACTGCCATCTGCTCTCAGTGTTCACCTCTGCAGGTCATCACCATGCTCAACGCTCTCTATACT
CGCTTTGACCAACAGTGTGGAGAGCTGGATGTCTACAAGGTGGAGACCATCGGAGATGCATATT
GTGTGGCAGGGGGATTGCACAGAGAGAGTGACACACATGCTGTCCAGATAGCACTGATGGCCCT
GAAGATGATGGAGCTCTCCAATGAGGTCATGTCTCCCCACGGAGAACCTATCAAGATGCGAATC
GGACTGCATTCTGGGTCAGTGTTTGCTGGAGTTGTTGGAGTGAAGATGCCCCGATATTGCCTGT
TTGGAAACAATGTCACTCTGGCTAACAAATTTGAGTCCTGCAGTGTGCCTCGGAAAATCAATGT
CAGCCCCACGACATACAGGTTACTCAAAGACTGTCCTGGCTTTGTGTTCACCCCGAGATCGAGG
GAGGAGCTTCCACCAAACTTCCCTAGTGACATTCCTGGAATCTGTCACTTTCTGGATGCTTATC
AACATCAAGGACCTAATTCTAAACCATGGTTCCAGCAGAAAGATGCAGAAGATGGAAACGCTAA
CTTCTTAGGCAAAGCATCAGGGGTAGATTAGTGAGCCGCATGTTTCTGTGTTTGATGCCTTTGA
GGGTGCGCAGAATCTCTGAAATGACTTTAGGATTGCAGAAGATAAAAAACTGTGTTAAAATTGC
AGGGGTGAAACCCAGTTTCCTCTGTTTCCCATTTAAGATGGAAAAAAAAAAGTGTTCAATGCTT
CAGCGCTTTCAACCTTCTTCTCTATTTAAGAAACAAACCTCAAAAGTGACTTGTGACTTTTGGG
GACATAGCTTTGTTCTAGAGCAGTCACTACCTGCACTCGAAATCCAACACAGTGTACATATTCC
AGACAATTGTAGTCAAGTTTAAGTGTCAAAGTAATGTACTCACCTGTGGCCTGTGACCAGTGCA
AACTGTGGTTATTACAGTGTGTCTGTGGTAGTGTTGCCTGTAAATCTCTGAATAGAAATGACAG
TGTTTAATTCTGCAAGAGCTTCCAGCCTCTTGACTCTACATTCAATTAGGTTTCCTTATTCTAT
CCTGGCGTATGTAACACAATAGGCCAGCGCCTTCTTCCCAGCTACATCTTTGTGCCTATGTACG
TGTTTTCCTTTCCTTTCCTTTCCTTTCCTTTTTTTTTTTTAAGAAAATAAGCAATTAGACATAG
GATAAAATGTGATATAAAGTAGTTCAGTAAGTGTCAAAGAATATTTTCATGTTTTGTCATTAAA
GATATTATCTATAGCACAATATATAATACAACAAATACTTTTCATTTTGATCCTATCTGTGATA
AAACATTTTAATTAATAGTAACAATGTACTTCCTACTAATCCATGTAAAATTTACTAATAGCAA
AACTTTCAGAGTAAAAGTATTTACATACATTGTTAAAATGCAATAACATTCAAATTTAATTAAG
GCATAGAATTAATATTTGCACACAGAGAGCCTACTGTAGAGGACAGTGGCAAAGTGTTCACAAA
CACACGTGTTTAAATGATCCTCTACTGCCGTGTTGAGCCATAAAAGCCAAGGGGAAAAGTTTTA
AGTCAGAAGTAGAAAAATAGACTTCATTTTGTCTTTTTTGATACCTTCTTAAGTATTTCTACTG
ACCATTTAGTGTATGTGTATGTGTTAAGAATCAAAATTTTTATTACTCAGTGTACACCTGTGAA
GTATTATTCTACTTTAAATATACTAATATTTTCTACAGAAACCACTAGTATCATTGAAGAAAAT
GTCACTATGATTTCATTATAGAGATCCTGATACGTTTTTTTTTCTTCTGGAGTTTAAACTAATG
TCCTTTCCTTCCCCTGCCCTCCTCTGCAGTCCTCTTTCTTCCTCTCCCATTGGGCATGTTTGTG
TGATTCTGTGGGCTGAACACAGGAACTGTGCATGCTGGGTAAAGACTGTTACTGAGTAACTTCC
TCACCATGGGGCTTCAGTTTTATTGCTAATGGTGACAGTTTACATTCCCGAGTGTTAATTTGGT
AAAAGGAAGTGACTTTAAAAGAAGACCAACTTCAAAGCCAAGAGAGATAGACATAATTGAATTT
TTCAATCAGTATTAGTAGAATGGTAGACATTCTGAATTTCTATGTGTGTAGTTGAAAAGAAACT
CAGTTTAAAAGTCATTTTCTACCTCCAATAGTCTTCAAGCATCCAGAGCAACAGACATCTTTTA
CCTAGCTCTAGTTTCCAAGGGGGACAACTAAACCACCCAATGGATTTCTTTAAAGGCGGATATT
GTCTCATTAAACAGTCACACTGATGTTGGATAGTGTCACGGGCCTTGCAAAGGTGTATTTAGGA
TGTCACAATGATGTGGAATTCAATGAATATTTATTAAGAAGGTAAAGAGGTAAATACCCCCTCT
TTCTGGAACTAATATTCAATACAGGGGAACTAGTAGGAATCACAGACAATTAGAAAGCGTAAAA
CAGGATGTCATCCTCTTAAGCTGTGCAGTTAGGTGGTTGCTACATTAGTAATAATCTGATTCAG
AAGCTTGCACATTAATTAGAATTAATTCTCCCACTGTCTTTTAGGGATGGTGATAGAACTCAAT
GACAAAGCACCTGCCTAGCATTTAGGCAGTCCTGTTCCGACCCAAGCAGCATGAAGGAATTACA
TGTATCTCTCATGTGCATATGATGTATGATCACACTCACCTGTGTCACCTGTGTACACACCTGG
GGCAAATGGAGGAACTGTATCTAATTCAAGGCAAACTACCGGAGCTCCATGTACGGTTCCTATA
ACTTTTCTATTATTTTGTCATTTTAGCTAAATAAAAACATTATCAAAAATTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_058786	(Get FASTA)	NCBI Sequence Viewer
	XP_006232580	(Get FASTA)	NCBI Sequence Viewer
	XP_008759329	(Get FASTA)	NCBI Sequence Viewer
	XP_017446500	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41206	(Get FASTA)	NCBI Sequence Viewer
	AAB17953	(Get FASTA)	NCBI Sequence Viewer
	AAH85746	(Get FASTA)	NCBI Sequence Viewer
	BAC24016	(Get FASTA)	NCBI Sequence Viewer
	EDM00849	(Get FASTA)	NCBI Sequence Viewer
	P19686	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_058786 ⟸ NM_017090

- UniProtKB:

Q5U330 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFCRKFKDLKITGECPFSLLAPGQVPTEPIEEVAGVSESCQATLPTCQEFAENAEGSHPQRKTS
RNRVYLHTLAESIGKLIFPEFERLNLALQRTLAKHKIKENRNSSEKEDLERIIAEEAIAAGVPV
EALKDSLGEELFKICYEEDEHILGVVGGTLKDFLNSFSTLLKQSSHCQEAERRGRLEDASILCL
DKDQDFLNVYYFFPKRTTALLLPGIIKAAARILYESHVEVSLMPPCFRSECTEFVNQPYLLYSV
HVKSTKPSLSPGKPQSSLVIPTSLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGKPNFE
EFFEILTPKINQTFSGIMTMLNMQFVIRVRRWDNLVKKSSRVMDLKGQMIYIVESSAILFLGSP
CVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEHAHQALEEEKKK
TVDLLCSIFPSEVAQQLWQGQIVQAKKFNEVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRF
DQQCGELDVYKVETIGDAYCVAGGLHRESDTHAVQIALMALKMMELSNEVMSPHGEPIKMRIGL
HSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREE
LPPNFPSDIPGICHFLDAYQHQGPNSKPWFQQKDAEDGNANFLGKASGVD

hide sequence

RefSeq Acc Id:	XP_006232580 ⟸ XM_006232518
- Peptide Label:	isoform X1
- UniProtKB:	Q5U330 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFCRKFKDLKITGECPFSLLAPGQVPTEPIEEVAGVSESCQATLPTCQEFAENAEGSHPQRKTS RNRVYLHTLAESIGKLIFPEFERLNLALQRTLAKHKIKENRNSSEKEDLERIIAEEAIAAGVPV EALKDSLGEELFKICYEEDEHILGVVGGTLKDFLNSFSTLLKQSSHCQEAERRGRLEDASILCL DKDQDFLNVYYFFPKRTTALLLPGIIKAAARILYESHVEVSLMPPCFRSECTEFVNQPYLLYSV HVKSTKPSLSPGKPQSSLVIPTSLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGKPNFE EFFEILTPKINQTFSGIMTMLNMQFVIRVRRWDNLVKKSSRVMDLKGQMIYIVESSAILFLGSP CVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEHAHQALEEEKKK TVDLLCSIFPSEVAQQLWQGQIVQAKKFNEVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRF DQQCGELDVYKVETIGDAYCVAGGLHRESDTHAVQIALMALKMMELSNEVMSPHGEPIKMRIGL HSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREE LPPNFPSDIPGICHFLDAYQHQGPNSKPWFQQKDAEDGNANFLGKASGVD hide sequence

RefSeq Acc Id:	XP_008759329 ⟸ XM_008761107
- Peptide Label:	isoform X1
- UniProtKB:	Q5U330 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFCRKFKDLKITGECPFSLLAPGQVPTEPIEEVAGVSESCQATLPTCQEFAENAEGSHPQRKTS RNRVYLHTLAESIGKLIFPEFERLNLALQRTLAKHKIKENRNSSEKEDLERIIAEEAIAAGVPV EALKDSLGEELFKICYEEDEHILGVVGGTLKDFLNSFSTLLKQSSHCQEAERRGRLEDASILCL DKDQDFLNVYYFFPKRTTALLLPGIIKAAARILYESHVEVSLMPPCFRSECTEFVNQPYLLYSV HVKSTKPSLSPGKPQSSLVIPTSLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGKPNFE EFFEILTPKINQTFSGIMTMLNMQFVIRVRRWDNLVKKSSRVMDLKGQMIYIVESSAILFLGSP CVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEHAHQALEEEKKK TVDLLCSIFPSEVAQQLWQGQIVQAKKFNEVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRF DQQCGELDVYKVETIGDAYCVAGGLHRESDTHAVQIALMALKMMELSNEVMSPHGEPIKMRIGL HSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREE LPPNFPSDIPGICHFLDAYQHQGPNSKPWFQQKDAEDGNANFLGKASGVD hide sequence

RefSeq Acc Id:	XP_017446500 ⟸ XM_017591011
- Peptide Label:	isoform X1
- UniProtKB:	Q5U330 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFCRKFKDLKITGECPFSLLAPGQVPTEPIEEVAGVSESCQATLPTCQEFAENAEGSHPQRKTS RNRVYLHTLAESIGKLIFPEFERLNLALQRTLAKHKIKENRNSSEKEDLERIIAEEAIAAGVPV EALKDSLGEELFKICYEEDEHILGVVGGTLKDFLNSFSTLLKQSSHCQEAERRGRLEDASILCL DKDQDFLNVYYFFPKRTTALLLPGIIKAAARILYESHVEVSLMPPCFRSECTEFVNQPYLLYSV HVKSTKPSLSPGKPQSSLVIPTSLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGKPNFE EFFEILTPKINQTFSGIMTMLNMQFVIRVRRWDNLVKKSSRVMDLKGQMIYIVESSAILFLGSP CVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEHAHQALEEEKKK TVDLLCSIFPSEVAQQLWQGQIVQAKKFNEVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRF DQQCGELDVYKVETIGDAYCVAGGLHRESDTHAVQIALMALKMMELSNEVMSPHGEPIKMRIGL HSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREE LPPNFPSDIPGICHFLDAYQHQGPNSKPWFQQKDAEDGNANFLGKASGVD hide sequence

RefSeq Acc Id:

ENSRNOP00000017190 ⟸ ENSRNOT00000017190

Protein Domains

Guanylate cyclase

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691392

Promoter ID:

EPDNEW_R1917

Type:

multiple initiation site

Name:

Gucy1a3_1

Description:

guanylate cyclase 1 soluble subunit alpha 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	181,102,872 - 181,102,932	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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CSV

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

Visual

CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

Visual

CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: RGSC_v3.4

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
2	173782485	173782486	G	T	snv	FHL/EurMcwi (MCW)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:68436	AgrOrtholog
Ensembl Genes	ENSRNOG00000012302	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000017190	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017190	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	3.30.450.260	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.70.1230	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.90.1520.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7190419	IMAGE-MGC_LOAD
InterPro	A/G_cyclase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	A/G_cyclase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	H-NOX_domain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HNOB_dom_associated	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HNOB_dom_associated_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NO_sig/Golgi_transp_ligand-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Nucleotide_cyclase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:497757	UniProtKB/TrEMBL
MGC_CLONE	MGC:93532	IMAGE-MGC_LOAD
NCBI Gene	497757	ENTREZGENE
Pfam	Guanylate_cyc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HNOBA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Gucy1a1	PhenoGen
PROSITE	GUANYLATE_CYCLASE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GUANYLATE_CYCLASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	CYCc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF111126	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55073	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC230155
UniProt	GCYA1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5U330	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Gucy1a3	guanylate cyclase 1, soluble, alpha 3			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_drugs	3-(5-Hydroxymethyl-2-furyl)-1-benzyl indazole (YC1) decreases expression	628495
gene_expression	expressed in lung and brain	61495
gene_expression	expressed in lung and brain	68258
gene_function	subunit of soluble guanylate cyclase, forms a heterodimer with Gucy1b3 that converts GTP to cGMP	61495
gene_function	intracellular nitric oxide receptor in vascular smooth muscle cells	628495
gene_physical_interaction	forms heterodimer with Gucy1b3	61495
gene_physical_interaction	forms heterodimer with Gucy1b3	68258
gene_process	may control salt-sensitive hypertension	61495
gene_process	activates cGMP-dependent protein kinase that induces vascular smooth muscle relaxation and prevents contractile agonist-elicited intracellular free Ca2+ mobilization, dephosphorylates myosin light chain kinase	628495
gene_process	hemoprotein mediating NO signaling by forming 3:5-cyclinc monophosphate (cGMP)	628495
gene_protein	76-81.5 kDa	628495
gene_regulation	protected mRNA-stabilizing protein HuR which binds to the 3-UTR; increased Gucy1a3 levels results in downregulation of HuR expression and autoregulation as a negative feedback response	628495
gene_regulation	mRNA and protein expression is decreased by beta-amyloid peptides in astroglial cells	1298937

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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