Exhibits ion binding activity. Contributes to adenylate cyclase activity and cytidylate cyclase activity. Involved in response to herbicide and response to organic cyclic compound. Localizes to guanylate cyclase complex, soluble. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1); PARTICIPATES IN long term depression; purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of GUCY1A1 mRNA
5-chloro-2-5-chlorothiophene-2-sulfonylamino-N-4-morpholine-4-sulfonylphenylbenzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]] more ...
[dicyanocobinamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]] which results in increased metabolism of Guanosine Triphosphate
5-chloro-2-5-chlorothiophene-2-sulfonylamino-N-4-morpholine-4-sulfonylphenylbenzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]] more ...
ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of GUCY1A1 mRNA], ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of GUCY1A1 protein]
+-JQ1 compound promotes the reaction [panobinostat affects the expression of GUCY1A1 mRNA], panobinostat promotes the reaction [+-JQ1 compound affects the expression of GUCY1A1 mRNA]
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of GUCY1A1 mRNA
potassium ferricyanide inhibits the reaction [1, 1-diethyl-2-hydroxy-2-nitrosohydrazine results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]
Polysorbates promotes the reaction [protoporphyrin IX results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]], protoporphyrin IX results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of GUCY1A1 mRNA
zinc protoporphyrin inhibits the reaction [5-chloro-2-5-chlorothiophene-2-sulfonylamino-N-4-morpholine-4-sulfonylphenylbenzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]], zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
protected mRNA-stabilizing protein HuR which binds to the 3-UTR; increased Gucy1a3 levels results in downregulation of HuR expression and autoregulation as a negative feedback response