Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68436
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gucy1a1
Name: guanylate cyclase 1 soluble subunit alpha 1
Acc ID: CHEBI:31653
Term: glafenine
Definition: A carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain, but high incidence of anaphylactic reactions resulted in their withdrawal from the market.
Chemical ID: MESH:D005897
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gucy1a1decreases expressionEXP 6480464CTDGlafenine results in decreased expression of GUCY1A1 mRNAPMID:24136188
Go Back to source page   Continue to Ontology report