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Gene: ERC2 (ELKS/RAB6-interacting/CAST family member 2) Homo sapiens
Symbol: ERC2
Name: ELKS/RAB6-interacting/CAST family member 2
Description: This gene encodes a protein that belongs to the Rab3-interacting molecule (RIM)-binding protein family. Members of this protein family form part of the cytomatrix at the active zone (CAZ) complex and function as regulators of neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAST; CAST1; CAZ-associated structural protein; cytomatrix protein p110; ELKSL; ERC protein 2; KIAA0378; MGC133063; MGC133064; SPBC110; Spc110
Mus musculus (house mouse) : Erc2 (ELKS/RAB6-interacting/CAST family member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Erc2 (ELKS/RAB6-interacting/CAST family member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Erc2 (ELKS/RAB6-interacting/CAST family member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ERC2 (ELKS/RAB6-interacting/CAST family member 2)
Canis lupus familiaris (dog) : ERC2 (ELKS/RAB6-interacting/CAST family member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101960052 (ERC protein 2)
Sus scrofa (pig) : ERC2 (ELKS/RAB6-interacting/CAST family member 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38355,508,311 - 56,468,473 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37355,542,336 - 56,502,391 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36355,517,376 - 56,477,431 (-)NCBINCBI36hg18NCBI36
Celera355,509,269 - 56,468,649 (-)NCBI
Cytogenetic Map3p14.3NCBI
HuRef355,591,133 - 56,551,243 (-)NCBIHuRef
CHM1_1355,493,674 - 56,453,566 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ERC2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1607056
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.