GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1) - Rat Genome Database

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Gene: GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1) Canis lupus familiaris
Analyze
Symbol: GUCY1A1
Name: guanylate cyclase 1 soluble subunit alpha 1
RGD ID: 12363944
Description: ENCODES a protein that exhibits adenylate cyclase activity (ortholog); cytidylate cyclase activity (ortholog); ion binding (ortholog); INVOLVED IN cGMP biosynthetic process (ortholog); positive regulation of nitric oxide mediated signal transduction (ortholog); regulation of blood pressure (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Colonic Neoplasms (ortholog); coronary artery disease (ortholog); FOUND IN guanylate cyclase complex, soluble (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: GCS-alpha-1; GCS-alpha-3; guanylate cyclase 1 soluble subunit alpha; guanylate cyclase soluble subunit alpha-1; guanylate cyclase soluble subunit alpha-3; GUCY1A3; soluble guanylate cyclase 1 alpha 3; soluble guanylate cyclase large subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11553,172,914 - 53,236,200 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1553,174,157 - 53,234,533 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1553,510,720 - 53,570,219 (+)NCBI
ROS_Cfam_1.01553,880,516 - 53,943,086 (+)NCBI
UMICH_Zoey_3.11553,134,895 - 53,194,847 (+)NCBI
UNSW_CanFamBas_1.01553,244,742 - 53,304,495 (+)NCBI
UU_Cfam_GSD_1.01553,557,797 - 53,618,055 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16113048  


Genomics

Comparative Map Data
GUCY1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11553,172,914 - 53,236,200 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1553,174,157 - 53,234,533 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1553,510,720 - 53,570,219 (+)NCBI
ROS_Cfam_1.01553,880,516 - 53,943,086 (+)NCBI
UMICH_Zoey_3.11553,134,895 - 53,194,847 (+)NCBI
UNSW_CanFamBas_1.01553,244,742 - 53,304,495 (+)NCBI
UU_Cfam_GSD_1.01553,557,797 - 53,618,055 (+)NCBI
GUCY1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4155,666,711 - 155,732,349 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl4155,666,726 - 155,737,059 (+)EnsemblGRCh38hg38GRCh38
GRCh384155,666,725 - 155,737,059 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374156,588,000 - 156,658,211 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364156,807,328 - 156,871,232 (+)NCBINCBI36hg18NCBI36
Build 344156,945,482 - 157,009,379NCBI
Celera4153,919,477 - 153,989,823 (+)NCBI
Cytogenetic Map4q32.1NCBI
HuRef4152,327,271 - 152,397,264 (+)NCBIHuRef
CHM1_14156,565,607 - 156,635,931 (+)NCBICHM1_1
Gucy1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39381,999,734 - 82,053,253 (-)NCBIGRCm39mm39
GRCm39 Ensembl381,999,734 - 82,053,096 (-)Ensembl
GRCm38382,092,427 - 82,145,946 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl382,092,427 - 82,145,789 (-)EnsemblGRCm38mm10GRCm38
MGSCv37381,896,349 - 81,949,799 (-)NCBIGRCm37mm9NCBIm37
MGSCv36382,178,354 - 82,231,000 (-)NCBImm8
Celera382,117,270 - 82,170,809 (-)NCBICelera
Cytogenetic Map3E3NCBI
Gucy1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22167,418,615 - 167,482,293 (-)NCBI
Rnor_6.0 Ensembl2181,045,703 - 181,102,918 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02181,045,694 - 181,103,321 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02200,453,480 - 200,515,219 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,756,824 - 173,818,316 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12173,705,122 - 173,768,506 (-)NCBI
Celera2161,450,514 - 161,511,622 (-)NCBICelera
Cytogenetic Map2q34NCBI
Gucy1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547111,367,282 - 11,424,273 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547111,367,318 - 11,422,199 (-)NCBIChiLan1.0ChiLan1.0
GUCY1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14159,850,092 - 159,920,159 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4159,850,107 - 159,913,338 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04148,032,167 - 148,102,757 (+)NCBIMhudiblu_PPA_v0panPan3
Gucy1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530137,135,116 - 37,192,728 (-)NCBI
SpeTri2.0NW_0049365762,353,874 - 2,411,747 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCY1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl844,449,232 - 44,518,135 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1844,448,758 - 44,520,737 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2846,457,572 - 46,537,279 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GUCY1A1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17102,206,438 - 102,310,535 (+)NCBI
ChlSab1.1 Ensembl7102,238,477 - 102,303,673 (+)Ensembl
Vero_WHO_p1.0NW_02366603781,715,008 - 81,968,286 (+)NCBI
Gucy1a1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248482,522,935 - 2,588,758 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 5 1 7
Low 1 21 6 6 6 6 6 5 10 6
Below cutoff 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001018035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005628839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005628841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005628842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014119231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038687193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038687194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038687195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038687196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038687197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ008575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000013544   ⟹   ENSCAFP00000012533
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1553,174,157 - 53,234,533 (+)Ensembl
RefSeq Acc Id: NM_001018035   ⟹   NP_001018045
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11553,174,157 - 53,234,535 (+)NCBI
Dog10K_Boxer_Tasha1553,510,720 - 53,570,219 (+)NCBI
ROS_Cfam_1.01553,881,383 - 53,941,408 (+)NCBI
UMICH_Zoey_3.11553,134,895 - 53,194,847 (+)NCBI
UNSW_CanFamBas_1.01553,244,742 - 53,304,495 (+)NCBI
UU_Cfam_GSD_1.01553,557,797 - 53,618,055 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005628839   ⟹   XP_005628896
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11553,173,885 - 53,236,200 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005628841   ⟹   XP_005628898
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11553,173,885 - 53,236,200 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005628842   ⟹   XP_005628899
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11553,173,252 - 53,236,200 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014119231   ⟹   XP_013974706
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11553,181,393 - 53,236,200 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022427665   ⟹   XP_022283373
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11553,173,304 - 53,236,200 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022427666   ⟹   XP_022283374
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11553,173,291 - 53,236,200 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022427667   ⟹   XP_022283375
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11553,181,393 - 53,236,200 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022427668   ⟹   XP_022283376
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11553,172,914 - 53,236,200 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038687193   ⟹   XP_038543121
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01553,882,927 - 53,943,086 (+)NCBI
RefSeq Acc Id: XM_038687194   ⟹   XP_038543122
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01553,881,108 - 53,943,086 (+)NCBI
RefSeq Acc Id: XM_038687195   ⟹   XP_038543123
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01553,882,924 - 53,943,086 (+)NCBI
RefSeq Acc Id: XM_038687196   ⟹   XP_038543124
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01553,889,083 - 53,943,086 (+)NCBI
RefSeq Acc Id: XM_038687197   ⟹   XP_038543125
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01553,880,516 - 53,943,086 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005628899   ⟸   XM_005628842
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005628896   ⟸   XM_005628839
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005628898   ⟸   XM_005628841
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001018045   ⟸   NM_001018035
- UniProtKB: Q4ZHS0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_013974706   ⟸   XM_014119231
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022283376   ⟸   XM_022427668
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022283374   ⟸   XM_022427666
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022283373   ⟸   XM_022427665
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022283375   ⟸   XM_022427667
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000012533   ⟸   ENSCAFT00000013544
RefSeq Acc Id: XP_038543125   ⟸   XM_038687197
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038543122   ⟸   XM_038687194
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038543123   ⟸   XM_038687195
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038543121   ⟸   XM_038687193
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038543124   ⟸   XM_038687196
- Peptide Label: isoform X1
Protein Domains
Guanylate cyclase

Promoters
RGD ID:13686006
Promoter ID:EPDNEW_C4076
Type:single initiation site
Name:GUCY1A1_1
Description:guanylate cyclase 1 soluble subunit alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11553,174,093 - 53,174,153EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008527 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000012533 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000013544 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.1230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  H-NOX_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heme_NO-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOB_dom_associated UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOB_dom_associated_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NO_sig/Golgi_transp_ligand-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:482663 UniProtKB/Swiss-Prot
NCBI Gene GUCY1A3 ENTREZGENE
Pfam Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HNOBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111126 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1P649_CANLF UniProtKB/TrEMBL
  GCYA1_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:41567 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-12-05 GUCY1A1  guanylate cyclase 1 soluble subunit alpha 1  GUCY1A3  guanylate cyclase 1 soluble subunit alpha  Symbol and/or name change 5135510 APPROVED