GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1) - Rat Genome Database

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Gene: GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1) Sus scrofa
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Symbol: GUCY1A1
Name: guanylate cyclase 1 soluble subunit alpha 1
RGD ID: 14168111
Description: ENCODES a protein that exhibits adenylate cyclase activity (ortholog); cytidylate cyclase activity (ortholog); ion binding (ortholog); INVOLVED IN cGMP biosynthetic process (ortholog); positive regulation of nitric oxide mediated signal transduction (ortholog); regulation of blood pressure (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Colonic Neoplasms (ortholog); coronary artery disease (ortholog); FOUND IN GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); guanylate cyclase complex, soluble (ortholog); INTERACTS WITH 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; cinaciguat
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: guanylate cyclase soluble subunit alpha-1; guanylate cyclase soluble subunit alpha-3; GUCY1A3; soluble guanylate cyclase 1 alpha 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl844,449,232 - 44,518,135 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1844,448,758 - 44,520,737 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2846,457,572 - 46,537,279 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:17384083  


Genomics

Comparative Map Data
GUCY1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl844,449,232 - 44,518,135 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1844,448,758 - 44,520,737 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2846,457,572 - 46,537,279 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GUCY1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4155,666,726 - 155,737,059 (+)EnsemblGRCh38hg38GRCh38
GRCh384155,666,725 - 155,737,059 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374156,588,000 - 156,658,211 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364156,807,328 - 156,871,232 (+)NCBINCBI36hg18NCBI36
Build 344156,945,482 - 157,009,379NCBI
Celera4153,919,477 - 153,989,823 (+)NCBI
Cytogenetic Map4q32.1NCBI
HuRef4152,327,271 - 152,397,264 (+)NCBIHuRef
CHM1_14156,565,607 - 156,635,931 (+)NCBICHM1_1
Gucy1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39381,999,734 - 82,053,253 (-)NCBIGRCm39mm39
GRCm39 Ensembl381,999,734 - 82,053,096 (-)Ensembl
GRCm38382,092,427 - 82,145,946 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl382,092,427 - 82,145,789 (-)EnsemblGRCm38mm10GRCm38
MGSCv37381,896,349 - 81,949,799 (-)NCBIGRCm37mm9NCBIm37
MGSCv36382,178,354 - 82,231,000 (-)NCBImm8
Celera382,117,270 - 82,170,809 (-)NCBICelera
Cytogenetic Map3E3NCBI
Gucy1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22167,418,615 - 167,482,293 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2167,418,640 - 167,481,671 (-)Ensembl
Rnor_6.02181,045,694 - 181,103,321 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2181,045,703 - 181,102,918 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02200,453,480 - 200,515,219 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,756,824 - 173,818,316 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12173,705,122 - 173,768,506 (-)NCBI
Celera2161,450,514 - 161,511,622 (-)NCBICelera
Cytogenetic Map2q34NCBI
Gucy1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547111,367,282 - 11,424,273 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547111,367,318 - 11,422,199 (-)NCBIChiLan1.0ChiLan1.0
GUCY1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14159,850,092 - 159,920,159 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4159,850,107 - 159,913,338 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04148,032,167 - 148,102,757 (+)NCBIMhudiblu_PPA_v0panPan3
GUCY1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11553,172,914 - 53,236,200 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1553,174,157 - 53,234,533 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1553,510,720 - 53,570,219 (+)NCBI
ROS_Cfam_1.01553,880,516 - 53,943,086 (+)NCBI
UMICH_Zoey_3.11553,134,895 - 53,194,847 (+)NCBI
UNSW_CanFamBas_1.01553,244,742 - 53,304,495 (+)NCBI
UU_Cfam_GSD_1.01553,557,797 - 53,618,055 (+)NCBI
Gucy1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530137,135,116 - 37,192,728 (-)NCBI
SpeTri2.0NW_0049365762,353,874 - 2,411,747 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCY1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17102,206,438 - 102,310,535 (+)NCBI
ChlSab1.1 Ensembl7102,238,477 - 102,303,673 (+)Ensembl
Vero_WHO_p1.0NW_02366603781,715,008 - 81,968,286 (+)NCBI
Gucy1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248482,522,935 - 2,588,758 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 1 1 8 1
Low 8 3 3 4 2 15 2 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000009706   ⟹   ENSSSCP00000009457
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl844,449,333 - 44,518,135 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000075197   ⟹   ENSSSCP00000063741
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl844,449,232 - 44,517,250 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000080422   ⟹   ENSSSCP00000071249
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl844,449,333 - 44,506,595 (+)Ensembl
RefSeq Acc Id: NM_001018033   ⟹   NP_001018043
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1844,449,415 - 44,517,147 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021100507   ⟹   XP_020956166
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1844,448,758 - 44,520,737 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021100508   ⟹   XP_020956167
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1844,449,784 - 44,520,724 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021100509   ⟹   XP_020956168
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1844,463,875 - 44,520,737 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021100510   ⟹   XP_020956169
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1844,448,901 - 44,520,737 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021100511   ⟹   XP_020956170
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1844,481,951 - 44,520,737 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020956166   ⟸   XM_021100507
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020956169   ⟸   XM_021100510
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001018043   ⟸   NM_001018033
- UniProtKB: Q4ZHR8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020956167   ⟸   XM_021100508
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020956168   ⟸   XM_021100509
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020956170   ⟸   XM_021100511
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000009457   ⟸   ENSSSCT00000009706
RefSeq Acc Id: ENSSSCP00000063741   ⟸   ENSSSCT00000075197
RefSeq Acc Id: ENSSSCP00000071249   ⟸   ENSSSCT00000080422
Protein Domains
Guanylate cyclase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000008866 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070014667 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000009457 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000063741 UniProtKB/TrEMBL
  ENSSSCP00000071249 UniProtKB/TrEMBL
  ENSSSCP00070023993 UniProtKB/TrEMBL
  ENSSSCP00070023996 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000009706 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000075197 UniProtKB/TrEMBL
  ENSSSCT00000080422 UniProtKB/TrEMBL
  ENSSSCT00070028791 UniProtKB/TrEMBL
  ENSSSCT00070028796 UniProtKB/TrEMBL
Gene3D-CATH 3.30.450.260 UniProtKB/TrEMBL
  3.30.70.1230 UniProtKB/TrEMBL
  3.90.1520.10 UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/TrEMBL
  H-NOX_domain_sf UniProtKB/TrEMBL
  Heme_NO-bd UniProtKB/TrEMBL
  HNOB_dom_associated UniProtKB/TrEMBL
  HNOB_dom_associated_sf UniProtKB/TrEMBL
  NO_sig/Golgi_transp_ligand-bd UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/TrEMBL
KEGG Report ssc:553100 UniProtKB/TrEMBL
NCBI Gene GUCY1A1 ENTREZGENE
Pfam Guanylate_cyc UniProtKB/TrEMBL
  HNOB UniProtKB/TrEMBL
  HNOBA UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/TrEMBL
SMART CYCc UniProtKB/TrEMBL
Superfamily-SCOP SSF111126 UniProtKB/TrEMBL
  SSF55073 UniProtKB/TrEMBL
UniProt A0A4X1U2Q9_PIG UniProtKB/TrEMBL
  A0A5G2QIK9_PIG UniProtKB/TrEMBL
  A0A5G2R2B9_PIG UniProtKB/TrEMBL
  Q4ZHR8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1RWB0 UniProtKB/TrEMBL
VGNC ID VGNC:88750 ENTREZGENE