Ptpn2 (protein tyrosine phosphatase, non-receptor type 2) - Rat Genome Database

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Gene: Ptpn2 (protein tyrosine phosphatase, non-receptor type 2) Rattus norvegicus
Analyze
Symbol: Ptpn2
Name: protein tyrosine phosphatase, non-receptor type 2
RGD ID: 620710
Description: Enables non-membrane spanning protein tyrosine phosphatase activity. Predicted to be involved in several processes, including hemopoiesis; negative regulation of leukocyte differentiation; and regulation of signal transduction. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; and nucleoplasm. Predicted to be active in endosome lumen and nucleus. Orthologous to human PTPN2 (protein tyrosine phosphatase non-receptor type 2); PARTICIPATES IN Jak-Stat signaling pathway; INTERACTS WITH 3H-1,2-dithiole-3-thione; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: protein-tyrosine phosphatase PTP-S; tyrosine-protein phosphatase non-receptor type 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81863,498,890 - 63,564,571 (-)NCBIGRCr8
mRatBN7.21861,229,012 - 61,294,662 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1861,229,014 - 61,294,627 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1863,299,451 - 63,364,988 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01863,998,201 - 64,063,739 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01861,848,043 - 61,912,763 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01863,415,298 - 63,489,240 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1863,415,306 - 63,488,027 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01862,600,260 - 62,671,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41864,205,920 - 64,271,288 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11864,279,120 - 64,344,489 (-)NCBI
Celera1859,335,151 - 59,399,819 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell differentiation  (IEA,ISO,ISS)
erythrocyte differentiation  (IEA,ISO,ISS)
glucose homeostasis  (IEA,ISO,ISS)
insulin receptor recycling  (IEA,ISO)
insulin receptor signaling pathway  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of chemotaxis  (IEA,ISO,ISS)
negative regulation of epidermal growth factor receptor signaling pathway  (IEA,ISO,ISS)
negative regulation of ERK1 and ERK2 cascade  (IBA,IEA,ISO,ISS)
negative regulation of inflammatory response  (IEA,ISO,ISS)
negative regulation of insulin receptor signaling pathway  (IEA,ISO,ISS)
negative regulation of interleukin-2-mediated signaling pathway  (IEA,ISO,ISS)
negative regulation of interleukin-4-mediated signaling pathway  (IEA,ISO,ISS)
negative regulation of interleukin-6-mediated signaling pathway  (IEA,ISO,ISS)
negative regulation of lipid storage  (IEA,ISO,ISS)
negative regulation of macrophage colony-stimulating factor signaling pathway  (IEA,ISO,ISS)
negative regulation of macrophage differentiation  (IEA,ISO,ISS)
negative regulation of platelet-derived growth factor receptor-beta signaling pathway  (IEA,ISO,ISS)
negative regulation of positive thymic T cell selection  (IEA,ISO,ISS)
negative regulation of receptor signaling pathway via JAK-STAT  (IBA)
negative regulation of T cell receptor signaling pathway  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (IEA,ISO,ISS)
negative regulation of type I interferon-mediated signaling pathway  (IEA,ISO,ISS)
negative regulation of type II interferon-mediated signaling pathway  (IEA,ISO,ISS)
negative regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO,ISS)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of gluconeogenesis  (IEA,ISO,ISS)
positive regulation of PERK-mediated unfolded protein response  (IEA,ISO)
regulation of hepatocyte growth factor receptor signaling pathway  (IEA,ISO,ISS)
T cell differentiation  (IEA,ISO,ISS)

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO,ISS)
endoplasmic reticulum-Golgi intermediate compartment  (IEA,ISO,ISS)
endosome lumen  (IEA,ISO)
nuclear membrane  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO,ISS)
plasma membrane  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Evaluation of MicroRNA-210 and Protein tyrosine phosphatase, non-receptor type 2 in Pre-eclampsia. Adel S, etal., Gene. 2017 Jan 5;596:105-109. doi: 10.1016/j.gene.2016.10.014. Epub 2016 Oct 13.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Alternative splicing generates four different forms of a non-transmembrane protein tyrosine phosphatase mRNA. Reddy RS and Swarup G, DNA Cell Biol 1995 Dec;14(12):1007-15.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. Molecular cloning and expression of a protein-tyrosine phosphatase showing homology with transcription factors Fos and Jun. Swarup G, etal., FEBS Lett 1991 Mar 11;280(1):65-9.
12. JAK/STAT signal transduction: regulators and implication in hematological malignancies. Valentino L and Pierre J, Biochem Pharmacol. 2006 Mar 14;71(6):713-21. Epub 2006 Jan 19.
Additional References at PubMed
PMID:7593185   PMID:8443161   PMID:9271584   PMID:10940933   PMID:11909529   PMID:12138178   PMID:12359225   PMID:12612081   PMID:14726372   PMID:14966296   PMID:15489334   PMID:15592458  
PMID:15632081   PMID:15696169   PMID:16705167   PMID:17210636   PMID:18819921   PMID:19336676   PMID:19825843   PMID:20484139   PMID:21216966   PMID:22080863   PMID:22976903   PMID:23006999  
PMID:24849651   PMID:26026268   PMID:32054021   PMID:35153255  


Genomics

Comparative Map Data
Ptpn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81863,498,890 - 63,564,571 (-)NCBIGRCr8
mRatBN7.21861,229,012 - 61,294,662 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1861,229,014 - 61,294,627 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1863,299,451 - 63,364,988 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01863,998,201 - 64,063,739 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01861,848,043 - 61,912,763 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01863,415,298 - 63,489,240 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1863,415,306 - 63,488,027 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01862,600,260 - 62,671,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41864,205,920 - 64,271,288 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11864,279,120 - 64,344,489 (-)NCBI
Celera1859,335,151 - 59,399,819 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
PTPN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381812,785,478 - 12,884,237 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1812,785,478 - 12,929,643 (-)EnsemblGRCh38hg38GRCh38
GRCh371812,785,477 - 12,884,236 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361812,775,480 - 12,874,334 (-)NCBINCBI36Build 36hg18NCBI36
Build 341812,783,247 - 12,874,334NCBI
Celera1812,668,269 - 12,766,833 (-)NCBICelera
Cytogenetic Map18p11.21NCBI
HuRef1812,739,218 - 12,838,298 (-)NCBIHuRef
CHM1_11812,784,828 - 12,883,350 (-)NCBICHM1_1
T2T-CHM13v2.01812,948,473 - 13,046,916 (-)NCBIT2T-CHM13v2.0
Ptpn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391867,798,571 - 67,857,697 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1867,798,581 - 67,857,665 (-)EnsemblGRCm39 Ensembl
GRCm381867,665,501 - 67,724,632 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1867,665,511 - 67,724,595 (-)EnsemblGRCm38mm10GRCm38
MGSCv371867,825,155 - 67,884,275 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361867,790,882 - 67,849,946 (-)NCBIMGSCv36mm8
Celera1868,948,003 - 69,006,677 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1840.06NCBI
Ptpn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955402771,410 - 846,671 (+)NCBIChiLan1.0ChiLan1.0
PTPN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21725,155,279 - 25,258,603 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11810,852,927 - 10,951,197 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0181,440,837 - 1,538,501 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11816,562,044 - 16,659,570 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1816,562,052 - 16,659,570 (+)Ensemblpanpan1.1panPan2
PTPN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1778,160,564 - 78,252,382 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl778,160,589 - 78,252,719 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha777,562,118 - 77,655,864 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0778,220,871 - 78,314,864 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl778,220,584 - 78,314,821 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1777,933,571 - 78,027,396 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0777,964,844 - 78,058,636 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0778,251,568 - 78,345,463 (-)NCBIUU_Cfam_GSD_1.0
Ptpn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049443,161,688 - 3,243,980 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366262,389,868 - 2,445,927 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366262,390,004 - 2,472,039 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl696,770,253 - 96,847,125 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1696,769,862 - 96,847,136 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2690,126,609 - 90,272,224 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11871,302,082 - 71,400,201 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1871,310,577 - 71,345,960 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605046,339,255 - 46,438,250 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477019,808,400 - 19,876,503 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477019,808,400 - 19,877,494 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptpn2
391 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:120
Interacting mature miRNAs:124
Transcripts:ENSRNOT00000023763, ENSRNOT00000063770
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)185880568763636873Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185933040970263868Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 39 57 41 19 41 8 8 74 35 40 11 8
Low 4 3 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000023763   ⟹   ENSRNOP00000023763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1861,229,014 - 61,294,627 (-)Ensembl
Rnor_6.0 Ensembl1863,415,306 - 63,488,027 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110632   ⟹   ENSRNOP00000093687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1861,234,585 - 61,294,620 (-)Ensembl
RefSeq Acc Id: NM_001414231   ⟹   NP_001401160
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,498,890 - 63,564,481 (-)NCBI
mRatBN7.21861,229,012 - 61,294,609 (-)NCBI
RefSeq Acc Id: NM_053990   ⟹   NP_446442
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,498,890 - 63,564,481 (-)NCBI
mRatBN7.21861,229,012 - 61,294,609 (-)NCBI
Rnor_6.01863,415,298 - 63,488,027 (-)NCBI
Rnor_5.01862,600,260 - 62,671,979 (-)NCBI
RGSC_v3.41864,205,920 - 64,271,288 (-)RGD
Celera1859,335,151 - 59,399,819 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772081   ⟹   XP_008770303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,504,449 - 63,564,571 (-)NCBI
mRatBN7.21861,230,975 - 61,294,662 (-)NCBI
Rnor_6.01863,420,780 - 63,489,237 (-)NCBI
Sequence:
RefSeq Acc Id: NP_446442   ⟸   NM_053990
- Peptide Label: isoform 1
- UniProtKB: P35233 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008770303   ⟸   XM_008772081
- Peptide Label: isoform X1
- UniProtKB: P35233 (UniProtKB/Swiss-Prot),   A0A8I6AMA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023763   ⟸   ENSRNOT00000023763
RefSeq Acc Id: ENSRNOP00000093687   ⟸   ENSRNOT00000110632
RefSeq Acc Id: NP_001401160   ⟸   NM_001414231
- Peptide Label: isoform 2
- UniProtKB: P35233 (UniProtKB/Swiss-Prot),   A0A8L2QCH4 (UniProtKB/TrEMBL),   A6IXW0 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35233-F1-model_v2 AlphaFold P35233 1-416 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700848
Promoter ID:EPDNEW_R11372
Type:multiple initiation site
Name:Ptpn2_1
Description:protein tyrosine phosphatase, non-receptor type 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01863,488,081 - 63,488,141EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620710 AgrOrtholog
BioCyc Gene G2FUF-7132 BioCyc
Ensembl Genes ENSRNOG00000017453 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023763.8 UniProtKB/TrEMBL
  ENSRNOT00000110632.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132485 IMAGE-MGC_LOAD
InterPro Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTP_cat UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Ptpn1/Ptpn2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
KEGG Report rno:117063 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93263 IMAGE-MGC_LOAD
NCBI Gene 117063 ENTREZGENE
PANTHER TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptpn2 PhenoGen
PIRSF Tyr-Ptase_nr1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017453 RatGTEx
SMART PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AMA6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QCH4 ENTREZGENE, UniProtKB/TrEMBL
  A6IXW0 ENTREZGENE, UniProtKB/TrEMBL
  A6IXW1_RAT UniProtKB/TrEMBL
  P35233 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Ptpn2  protein tyrosine phosphatase, non-receptor type 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ptpn2  protein tyrosine phosphatase, non-receptor type 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology non-catalytic region has similarity to Jun and Fos basic domains 729681