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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620710
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptpn2
Name: protein tyrosine phosphatase, non-receptor type 2
Acc ID: CHEBI:16509
Term: 1,4-benzoquinone
Definition: The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
Chemical ID: MESH:C004532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptpn2multiple interactionsISOPTPN2 (Homo sapiens)6480464CTD[[[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone] which results in decreased activity of PTPN2 protein; Glutathione inhibits the reaction [quinone results in decreased activity of PTPN2 protein]; quinone binds to and results in decreased activity of PTPN2 protein; Vanadates inhibits the reaction [quinone results in decreased activity of PTPN2 protein]PMID:31248982
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