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Gene: PTPN2 (protein tyrosine phosphatase non-receptor type 2) Homo sapiens
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Symbol: PTPN2
Name: protein tyrosine phosphatase non-receptor type 2
Description: Exhibits protein tyrosine phosphatase activity; signaling receptor binding activity; and syntaxin binding activity. Involved in several processes, including negative regulation of signal transduction; peptidyl-tyrosine dephosphorylation; and regulation of hepatocyte growth factor receptor signaling pathway. Localizes to several cellular components, including endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; and nucleoplasm. Colocalizes with plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: PTN2; PTPT; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TC-PTP; TCELLPTP; TCPTP; tyrosine-protein phosphatase non-receptor type 2
Orthologs:
Mus musculus (house mouse) : Ptpn2 (protein tyrosine phosphatase, non-receptor type 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptpn2 (protein tyrosine phosphatase, non-receptor type 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptpn2 (protein tyrosine phosphatase non-receptor type 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPN2 (protein tyrosine phosphatase non-receptor type 2)
Canis lupus familiaris (dog) : PTPN2 (protein tyrosine phosphatase non-receptor type 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptpn2 (protein tyrosine phosphatase non-receptor type 2)
Sus scrofa (pig) : PTPN2 (protein tyrosine phosphatase non-receptor type 2)
Chlorocebus sabaeus (African green monkey) : PTPN2 (protein tyrosine phosphatase non-receptor type 2)
Heterocephalus glaber (naked mole-rat) : Ptpn2 (protein tyrosine phosphatase non-receptor type 2)
more info ...
Related Pseudogenes: PTPN2P1   PTPN2P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1812,785,478 - 12,929,643 (-)EnsemblGRCh38hg38GRCh38
GRCh381812,785,478 - 12,884,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371812,785,477 - 12,884,337 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361812,775,480 - 12,874,334 (-)NCBINCBI36hg18NCBI36
Build 341812,783,247 - 12,874,334NCBI
Celera1812,668,269 - 12,766,833 (-)NCBI
Cytogenetic Map18p11.21NCBI
HuRef1812,739,218 - 12,838,298 (-)NCBIHuRef
CHM1_11812,784,828 - 12,883,350 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Sequence

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Nomenclature History
 
More on PTPN2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733575
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.