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Gene: Fbxw7 (F-box and WD repeat domain containing 7) Rattus norvegicus
Symbol: Fbxw7
Name: F-box and WD repeat domain containing 7
Description: Predicted to have several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; positive regulation of cellular protein metabolic process; and regulation of mitochondrion organization. Predicted to localize to several cellular components, including the Parkin-FBXW7-Cul1 ubiquitin ligase complex; nuclear lumen; and perinuclear region of cytoplasm. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH rotenone; (-)-demecolcine (ortholog); 17alpha-ethynylestradiol (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; F-box and WD-40 domain protein 7; F-box/WD repeat-containing protein 7; LOC100360914
Homo sapiens (human) : FBXW7 (F-box and WD repeat domain containing 7)  HGNC  Alliance
Mus musculus (house mouse) : Fbxw7 (F-box and WD-40 domain protein 7)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fbxw7 (F-box and WD repeat domain containing 7)
Pan paniscus (bonobo/pygmy chimpanzee) : FBXW7 (F-box and WD repeat domain containing 7)
Canis lupus familiaris (dog) : FBXW7 (F-box and WD repeat domain containing 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fbxw7 (F-box and WD repeat domain containing 7)
Sus scrofa (pig) : FBXW7 (F-box and WD repeat domain containing 7)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02184,230,191 - 184,309,805 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2184,231,260 - 184,309,664 (-)Ensembl
Rnor_5.02203,633,724 - 203,708,120 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42176,675,226 - 176,750,737 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2164,144,641 - 164,303,043 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Fbxw7
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2321145
Created: 2010-05-05
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.