Ttpa (alpha tocopherol transfer protein) - Rat Genome Database

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Gene: Ttpa (alpha tocopherol transfer protein) Rattus norvegicus
Analyze
Symbol: Ttpa
Name: alpha tocopherol transfer protein
RGD ID: 3915
Description: Enables vitamin E binding activity. Involved in several processes, including intracellular pH reduction; response to pH; and vitamin E metabolic process. Located in cytosol and late endosome. Biomarker of liver benign neoplasm. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-tocopherol transfer protein; alpha-tocopherol transfer protein-like; alpha-TTP; LOC100909929; tocopherol (alpha) transfer protein; Tocopherol transfer protein alpha; TTP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2533,497,537 - 33,518,936 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl533,497,137 - 33,518,073 (+)Ensembl
Rnor_6.0534,007,926 - 34,029,315 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl534,007,920 - 34,028,452 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0538,661,259 - 38,681,785 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4534,638,551 - 34,659,077 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1534,638,729 - 34,659,256 (+)NCBI
Celera532,573,008 - 32,593,536 (+)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IDA)
late endosome  (IBA,IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. alpha-tocopherol transfer protein stimulates the secretion of alpha-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway. Arita M, etal., Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12437-41.
2. alpha-Tocopherol transfer protein expression in rat liver exposed to hyperoxia. Ban R, etal., Free Radic Res. 2002 Sep;36(9):933-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. pH-dependent translocation of alpha-tocopherol transfer protein (alpha-TTP) between hepatic cytosol and late endosomes. Horiguchi M, etal., Genes Cells. 2003 Oct;8(10):789-800.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein. Ouahchi K, etal., Nat Genet. 1995 Feb;9(2):141-5.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Primary structure of alpha-tocopherol transfer protein from rat liver. Homology with cellular retinaldehyde-binding protein. Sato Y, etal., J Biol Chem 1993 Aug 25;268(24):17705-10.
14. Liver alpha-tocopherol transfer protein and its mRNA are differentially altered by dietary vitamin E deficiency and protein insufficiency in rats. Shaw HM and Huang C, J Nutr. 1998 Dec;128(12):2348-54.
15. A novel role for alpha-tocopherol transfer protein (alpha-TTP) in protecting against chloroquine toxicity. Shichiri M, etal., J Biol Chem. 2012 Jan 20;287(4):2926-34. doi: 10.1074/jbc.M111.321281. Epub 2011 Dec 6.
16. Developmental changes in the expression of alpha-tocopherol transfer protein during the neonatal period of rat. Tamai H, etal., Biofactors. 1998;7(1-2):87-91.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Correlation of repressed transcription of alpha-tocopherol transfer protein with serum alpha-tocopherol during hepatocarcinogenesis. Wu CG, etal., Int J Cancer. 1997 May 16;71(4):686-90.
19. Identification, purification, and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol. Yoshida H, etal., J Lipid Res. 1992 Mar;33(3):343-50.
Additional References at PubMed
PMID:11076932   PMID:11095717   PMID:16014812   PMID:16024914   PMID:16257640   PMID:19923370   PMID:23535541   PMID:23599266   PMID:24231105   PMID:25866300  


Genomics

Comparative Map Data
Ttpa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2533,497,537 - 33,518,936 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl533,497,137 - 33,518,073 (+)Ensembl
Rnor_6.0534,007,926 - 34,029,315 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl534,007,920 - 34,028,452 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0538,661,259 - 38,681,785 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4534,638,551 - 34,659,077 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1534,638,729 - 34,659,256 (+)NCBI
Celera532,573,008 - 32,593,536 (+)NCBICelera
Cytogenetic Map5q13NCBI
TTPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38863,059,488 - 63,086,053 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl863,048,553 - 63,086,053 (-)EnsemblGRCh38hg38GRCh38
GRCh37863,972,047 - 63,998,612 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36864,135,985 - 64,161,166 (-)NCBINCBI36hg18NCBI36
Build 34864,135,984 - 64,161,166NCBI
Celera859,962,246 - 59,988,643 (-)NCBI
Cytogenetic Map8q12.3NCBI
HuRef859,459,917 - 59,486,481 (-)NCBIHuRef
CHM1_1864,025,060 - 64,051,623 (-)NCBICHM1_1
T2T-CHM13v2.0863,484,060 - 63,510,623 (-)NCBI
Ttpa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39420,007,867 - 20,030,822 (+)NCBIGRCm39mm39
GRCm39 Ensembl420,007,938 - 20,030,785 (+)Ensembl
GRCm38420,007,894 - 20,030,822 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl420,007,938 - 20,030,785 (+)EnsemblGRCm38mm10GRCm38
MGSCv37419,935,575 - 19,957,932 (+)NCBIGRCm37mm9NCBIm37
MGSCv36419,935,575 - 19,957,932 (+)NCBImm8
Celera419,766,254 - 19,788,914 (+)NCBICelera
Cytogenetic Map4A3NCBI
cM Map47.76NCBI
Ttpa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544415,869,940 - 15,894,544 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544415,877,972 - 15,891,949 (+)NCBIChiLan1.0ChiLan1.0
TTPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1861,266,954 - 61,293,165 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl861,266,954 - 61,293,699 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0859,591,592 - 59,619,658 (-)NCBIMhudiblu_PPA_v0panPan3
TTPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12913,177,690 - 13,198,910 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2913,182,308 - 13,192,553 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2913,507,263 - 13,526,254 (-)NCBI
ROS_Cfam_1.02913,283,050 - 13,302,075 (-)NCBI
ROS_Cfam_1.0 Ensembl2913,283,050 - 13,302,076 (-)Ensembl
UMICH_Zoey_3.12913,294,501 - 13,313,489 (-)NCBI
UNSW_CanFamBas_1.02913,412,121 - 13,431,143 (-)NCBI
UU_Cfam_GSD_1.02913,677,780 - 13,696,792 (-)NCBI
Ttpa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530364,318,193 - 64,375,529 (-)NCBI
SpeTri2.0NW_00493649610,409,948 - 10,466,722 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl470,961,465 - 70,980,876 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1470,960,580 - 70,980,883 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2477,238,492 - 77,250,293 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1858,952,685 - 58,979,083 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl858,950,626 - 58,978,258 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603982,604,603 - 82,632,422 (+)NCBIVero_WHO_p1.0
Ttpa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474428,713,320 - 28,739,539 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474428,713,596 - 28,738,435 (+)NCBIHetGla_female_1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)52483871044045280Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:231
Count of miRNA genes:152
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000009611
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 35 35 9 1 2
Low 2 22 22 6 16 6 6 6 61 35 35 9 6
Below cutoff 19 3 2 2 4 5 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009611   ⟹   ENSRNOP00000009611
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl533,497,456 - 33,518,073 (+)Ensembl
Rnor_6.0 Ensembl534,007,920 - 34,028,452 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103084   ⟹   ENSRNOP00000088814
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl533,497,137 - 33,518,073 (+)Ensembl
RefSeq Acc Id: NM_013048   ⟹   NP_037180
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2533,497,537 - 33,518,073 (+)NCBI
Rnor_6.0534,007,926 - 34,028,452 (+)NCBI
Rnor_5.0538,661,259 - 38,681,785 (+)NCBI
RGSC_v3.4534,638,551 - 34,659,077 (+)RGD
Celera532,573,008 - 32,593,536 (+)RGD
Sequence:
RefSeq Acc Id: XM_017593163   ⟹   XP_017448652
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2533,499,819 - 33,518,936 (+)NCBI
Rnor_6.0534,010,970 - 34,029,315 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593164   ⟹   XP_017448653
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2533,497,579 - 33,518,936 (+)NCBI
Rnor_6.0534,007,968 - 34,029,315 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109317   ⟹   XP_038965245
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2533,497,613 - 33,518,936 (+)NCBI
RefSeq Acc Id: XM_039109318   ⟹   XP_038965246
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2533,499,563 - 33,518,936 (+)NCBI
RefSeq Acc Id: XM_039109319   ⟹   XP_038965247
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2533,503,933 - 33,518,936 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_037180   ⟸   NM_013048
- UniProtKB: P41034 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448653   ⟸   XM_017593164
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017448652   ⟸   XM_017593163
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000009611   ⟸   ENSRNOT00000009611
RefSeq Acc Id: XP_038965245   ⟸   XM_039109317
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965246   ⟸   XM_039109318
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038965247   ⟸   XM_039109319
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000088814   ⟸   ENSRNOT00000103084
Protein Domains
CRAL-TRIO

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41034-F1-model_v2 AlphaFold P41034 1-278 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693591
Promoter ID:EPDNEW_R4116
Type:initiation region
Name:Ttpa_1
Description:alpha tocopherol transfer protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0534,007,927 - 34,007,987EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3915 AgrOrtholog
BioCyc Gene G2FUF-41833 BioCyc
Ensembl Genes ENSRNOG00000007139 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009611 ENTREZGENE
  ENSRNOP00000009611.2 UniProtKB/TrEMBL
  ENSRNOP00000088814 ENTREZGENE
  ENSRNOP00000088814.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009611 ENTREZGENE
  ENSRNOT00000009611.3 UniProtKB/TrEMBL
  ENSRNOT00000103084 ENTREZGENE
  ENSRNOT00000103084.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.525.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CRAL-TRIO_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL-TRIO_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL/TRIO_N_dom UniProtKB/Swiss-Prot
  CRAL/TRIO_N_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25571 UniProtKB/Swiss-Prot
NCBI Gene 25571 ENTREZGENE
Pfam CRAL_TRIO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL_TRIO_N UniProtKB/Swiss-Prot
PhenoGen Ttpa PhenoGen
PROSITE CRAL_TRIO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CRAL_TRIO_N UniProtKB/Swiss-Prot
  SEC14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46938 UniProtKB/Swiss-Prot
  SSF52087 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216679
UniProt A0A8I6GHG2_RAT UniProtKB/TrEMBL
  A0A8L2Q527_RAT UniProtKB/TrEMBL
  P41034 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ttpa  alpha tocopherol transfer protein  LOC100909929  alpha-tocopherol transfer protein-like  Data Merged 737654 PROVISIONAL
2016-06-03 Ttpa  alpha tocopherol transfer protein  Ttpa  tocopherol (alpha) transfer protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909929  alpha-tocopherol transfer protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Ttpa  tocopherol (alpha) transfer protein    Tocopherol transfer protein alpha  Name updated 629478 APPROVED
2002-06-10 Ttpa  Tocopherol transfer protein alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds alpha-Tocopherol 730016