Procr (protein C receptor) - Rat Genome Database

Name: Procr
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Procr (protein C receptor) Rattus norvegicus

Analyze

Symbol:

Procr

Name:

protein C receptor

RGD ID:

1305991

Description:

Predicted to have signaling receptor activity. Predicted to be involved in negative regulation of coagulation. Localizes to extracellular space and perinuclear region of cytoplasm. Biomarker of acute kidney failure and carotid stenosis. Orthologous to human PROCR (protein C receptor); PARTICIPATES IN protease mediated signaling via protease-activated receptor 1; protein C anticoagulant pathway; INTERACTS WITH (+)-schisandrin B; 3,3',5,5'-tetrabromobisphenol A; 4,4'-diaminodiphenylmethane.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

activated protein C receptor; APC receptor; endothelial cell protein C receptor; endothelial protein C receptor; EPCR; LOC362248; MGC114418; MGC116255; protein C receptor, endothelial

Orthologs:

Homo sapiens (human) : PROCR (protein C receptor) HGNC Alliance
Mus musculus (house mouse) : Procr (protein C receptor, endothelial) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Procr (protein C receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : PROCR (protein C receptor)
Canis lupus familiaris (dog) : PROCR (protein C receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Procr (protein C receptor)
Sus scrofa (pig) : PROCR (protein C receptor)
Chlorocebus sabaeus (African green monkey) : PROCR (protein C receptor)
Heterocephalus glaber (naked mole-rat) : Procr (protein C receptor)

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PROCR (protein C receptor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Procr (protein C receptor, endothelial)	HGNC	EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Procr (protein C receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PROCR (protein C receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PROCR (protein C receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Procr (protein C receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PROCR (protein C receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	PROCR (protein C receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Procr (protein C receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PROCR (protein C receptor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Procr (protein C receptor, endothelial)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

NCBI Annotation Information:

Annotation category: suggests misassembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	3	151,285,321 - 151,289,581 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	151,285,249 - 151,289,595 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	157,650,408 - 157,654,716 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	146,268,567 - 146,273,718 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	146,174,188 - 146,179,297 (+)	NCBI
Celera	3	142,978,809 - 142,983,065 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (IEP)

Acute Lung Injury (IEP)

carotid stenosis (IEP)

coronary artery disease (ISO)

Experimental Liver Cirrhosis (ISO)

Experimental Pancreatitis, Acute (IDA,IEP)

Inflammation (ISO)

long QT syndrome (ISO)

Myocardial Reperfusion Injury (IDA)

Peripheral Nerve Injuries (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-tert-butylhydroquinone (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP)

amphibole asbestos (EXP)

anthra[1,9-cd]pyrazol-6(2H)-one (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

Benzo[k]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

choline (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP)

diclofenac (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

etoposide (ISO)

fluvastatin (ISO)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

glutathione (ISO)

hypochlorous acid (ISO)

indometacin (ISO)

L-methionine (ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

methotrexate (ISO)

methyl methacrylate (ISO)

methyl methanesulfonate (ISO)

Methylthiouracil (ISO)

N-nitrosodiethylamine (ISO)

N-nitrosodimethylamine (EXP)

nickel atom (ISO)

O-methyleugenol (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

paraquat (EXP)

phenylephrine (EXP)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

propanal (ISO)

quercetin (ISO)

rosmarinic acid (ISO)

rotenone (EXP)

SB 203580 (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

Soman (EXP)

succimer (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (EXP)

topotecan (EXP)

troglitazone (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vorinostat (ISO)

withaferin A (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

blood coagulation (IEA)

negative regulation of coagulation (IBA,ISO)

Cellular Component

centrosome (ISO)

extracellular space (IBA,IDA)

integral component of membrane (IEA)

perinuclear region of cytoplasm (IDA)

Molecular Function

protein binding (ISO)

signaling receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

protease mediated signaling via protease-activated receptor 1 (ISO)

protein C anticoagulant pathway (ISO,ISS)

References

References - curated


1.	Bouwens EA, etal., J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53. doi: 10.1111/jth.12247.
2.	Dahlback B and Villoutreix BO, FEBS Lett. 2005 Jun 13;579(15):3310-6. Epub 2005 Mar 13.
3.	Esmon CT, Chest. 2003 Sep;124(3 Suppl):26S-32S.
4.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Ge N, etal., Gastroenterol Res Pract. 2015;2015:235017. doi: 10.1155/2015/235017. Epub 2015 Jan 22.
6.	Ge N, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 Mar;45(2):230-4.
7.	Gera O, etal., Neuroscience. 2016 Dec 17;339:587-598. doi: 10.1016/j.neuroscience.2016.10.034. Epub 2016 Oct 19.
8.	GOA data from the GO Consortium
9.	Guillou S, etal., Thromb Res. 2016 May;141:98-103. doi: 10.1016/j.thromres.2016.02.009. Epub 2016 Feb 18.
10.	Kang K, etal., Shock. 2013 Aug;40(2):136-43. doi: 10.1097/SHK.0b013e31829d23f5.
11.	Lee MY, etal., Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2665-75. doi: 10.1161/ATVBAHA.111.235960.
12.	Lu ZQ, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009 Aug;27(8):453-6.
13.	MGD data from the GO Consortium
14.	RGD automated data pipeline
15.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	RGD automated import pipeline for gene-chemical interactions
17.	RGD comprehensive gene curation

Additional References at PubMed

PMID:8449997	PMID:12477932	PMID:15489334	PMID:19581412	PMID:19680809	PMID:19696402	PMID:21423176	PMID:23376485	PMID:23533145

Genomics

Comparative Map Data

Procr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	3	151,285,321 - 151,289,581 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	151,285,249 - 151,289,595 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	157,650,408 - 157,654,716 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	146,268,567 - 146,273,718 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	146,174,188 - 146,179,297 (+)	NCBI
Celera	3	142,978,809 - 142,983,065 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

PROCR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	20	35,172,072 - 35,216,240 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	20	35,172,072 - 35,215,989 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	20	33,759,740 - 33,803,771 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	33,223,435 - 33,228,826 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	20	33,223,434 - 33,228,826	NCBI
Celera	20	30,508,610 - 30,514,000 (+)	NCBI
Cytogenetic Map	20	q11.22	NCBI
HuRef	20	30,537,700 - 30,543,125 (+)	NCBI		HuRef
CHM1_1	20	33,661,021 - 33,666,433 (+)	NCBI		CHM1_1

Procr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	155,592,159 - 155,597,398 (+)	NCBI
GRCm38	2	155,751,125 - 155,755,478 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	155,751,117 - 155,755,471 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	155,576,953 - 155,581,214 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	2	155,442,784 - 155,446,899 (+)	NCBI			mm8
Celera	2	161,683,558 - 161,687,794 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI

Procr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	26,216,002 - 26,220,101 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	26,215,757 - 26,220,396 (-)	NCBI	ChiLan1.0	ChiLan1.0

PROCR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	20	32,622,876 - 32,666,612 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	32,622,876 - 32,628,320 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	20	31,500,838 - 31,543,928 (+)	NCBI

PROCR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	24	24,184,370 - 24,187,910 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	24	24,184,063 - 24,188,452 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Procr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936561	5,557,640 - 5,562,981 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PROCR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	38,532,554 - 38,537,397 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	38,532,530 - 38,537,397 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	43,729,977 - 43,734,533 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PROCR
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1 Ensembl	2	39,476,110 - 39,481,641 (+)	Ensembl
ChlSab1.1	2	39,464,322 - 39,481,498 (+)	NCBI

Procr
(Heterocephalus glaber - naked mole-rat)

No map positions available.

Position Markers

AI072354

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	151,289,260 - 151,289,476	NCBI	Rnor6.0
Rnor_5.0	3	157,654,395 - 157,654,611	UniSTS	Rnor5.0
Celera	3	142,982,748 - 142,982,960	UniSTS
Cytogenetic Map	3	q42	UniSTS
RH 3.4 Map	3	1303.7	UniSTS

BF401256

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	151,286,184 - 151,286,300	NCBI	Rnor6.0
Rnor_5.0	3	157,651,319 - 157,651,435	UniSTS	Rnor5.0
RGSC_v3.4	3	146,269,456 - 146,269,572	UniSTS	RGSC3.4
Celera	3	142,979,672 - 142,979,788	UniSTS
Cytogenetic Map	3	q42	UniSTS
RH 3.4 Map	3	1306.0	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	30846101	172879276	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	43295930	163640485	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	43295930	163640485	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	45406058	177699992	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	48561928	155263151	Rat
1581568	Rf53	Renal function QTL 53			total urine protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	58204463	170534769	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	61241033	165369047	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	total urine protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	81136227	154416635	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	99465522	168732722	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	102152812	155263151	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	103141814	176418101	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	103141814	176418101	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	103141814	176418101	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	103141944	170934860	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	114376250	159376250	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	119471263	164471263	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	125848628	170848628	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	126575595	153412619	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	126575595	165355668	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	128986468	173986468	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	129787213	177699992	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	130006659	175006659	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	132875075	176418101	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	136876155	170935007	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	138374177	177699992	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	138374177	177699992	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	139578365	177699992	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	146232777	177699992	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	147072047	154807958	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	148034701	177699992	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	148348517	171467264	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	148348739	163640325	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	150368003	177699992	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	315
Count of miRNA genes:	195
Interacting mature miRNAs:	234
Transcripts:	ENSRNOT00000055254
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		30	2	2	9	2					28	5
Low	3	13	55	39	10	39	8	11	74	35	13	6	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AABR07054384	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01026026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC099115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221148	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229445	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000055254 ⟹ ENSRNOP00000052129

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	151,285,249 - 151,289,595 (+)	Ensembl

RefSeq Acc Id:

NM_001025733 ⟹ NP_001020904

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	151,285,321 - 151,289,581 (+)	NCBI
Rnor_5.0	3	157,650,408 - 157,654,716 (+)	NCBI
RGSC_v3.4	3	146,268,567 - 146,273,718 (+)	RGD
Celera	3	142,978,809 - 142,983,065 (+)	RGD

Sequence:

show sequence

GGTCTCTTTCCACCCTTCCCTCTCCCTCCCGCCCTTCCCGGACAGCCGCCCTTCTCTTTCCTAA
TCAGCAACCTCAGGAGCCCGAGCCTGCCCGGACCCAGGTGGGACCCAGAACTTCAGCTCCAGGA
TGTTGACGAAGTTTCTGTCGCTGCTGCTGCTGCTGCTGCTGCTTGGCTGCGCCTTTTGTAACTC
CGATGGCTCCCAAAGCCTGCACATGCTCCAGATCTCCTACTTCCCAGACCCCTATCACGGGAGG
CATCAGGGCAACGCCTCTCTGGGAAAACTCCTGACACACACGCTGGAAGGCCCGAGCAACAACG
TCACCATTCTCCAGCTCCAGGACTGGCAGGATCCGGATAGCTGGGCGCGCACAGAGAGTGGCCT
GAAGATCTACCTGTCCCAGTTCAACAGCCTGGTGCAGTTGATCTATCGCGAGCGCAAGAACGAC
GTGGTCTTTCCTCTGACTGTTAGCTGCTCCGTGGGCTGTGAGCTGCCGCCAGAGGAGGGCTCTG
AACCCCATGTCTTCTTTGATGTGGCTGTGAATGGAAGTGCCTTCGTAAGTTTCCAGCCAAAGAC
TGCCATATGGGTGACAGGCTCCCAGGAGCCCTCCGAAGCCATCAACTTCACCCTGAAGCAACTC
AATACCTACAATCGGACTCGGTATGAACTGCAGGAATTTCTGCAGGACACCTGTGTGCAGTACC
TGGAGAACCACATCACCACGCAAAACACCAAAGGGAGCCAAACAGGCCGCTCTTATACTTCACT
GGTCCTGGGTATCCTGATGGGCTGTTTCATAATCGCTGGTGTGGCCGTGGGCATCTTCCTGTGC
ACGGGTGGACGGCGTTGCTAATTTTTCTCCAGGTTCCTCAGAGAAAGGGCTGGACTGGTGGGAG
CTGGTATGGGAAGGTCAAATGAAGCCAAACAGACTCCCCCAGCGGGCCACCATATCTCAGGAGG
TTAGAGCAACAGCTCCAGCATCTGCCTACGAAGAATGTGAGGAAGGGATATGAGGAGGTTATGT
AGACAAAATAACCGGTTTGCAAAGGACTCGAGAACATGCATGCTTTGGGTAGCTGGTCTGAGAA
GTGGGTGTTTATCTGTGAAAATGAGATCATAGACTTGGGGGGAGGCCAGGAGGTCTGCGACCTC
CCGGAATGGGCAGATTTACTGTAGGCATTCAAAACATCTAACTAAAATAAAAGGAATTGTCTGT
CACCAAAATAAAACATTTAATGTATCCAGGTGTGTCCAACTTGGGAAGGGACACTGGTATGATA
GGGAAGAAAGAACCATAGAAATGTCACAGTTGTAAGATTAATTAATATTGGAAGCAGTTAATTA
ATAATTAAATATTAAAATTTCTTATTTATGTAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001020904	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97380	(Get FASTA)	NCBI Sequence Viewer
	AAH99115	(Get FASTA)	NCBI Sequence Viewer
	EDL85897	(Get FASTA)	NCBI Sequence Viewer
	EDL85898	(Get FASTA)	NCBI Sequence Viewer
	EDL85899	(Get FASTA)	NCBI Sequence Viewer
	EDL85900	(Get FASTA)	NCBI Sequence Viewer
	Q4V8I1	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001020904 ⟸ NM_001025733
- Peptide Label:	precursor
- UniProtKB:	Q4V8I1 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLTKFLSLLLLLLLLGCAFCNSDGSQSLHMLQISYFPDPYHGRHQGNASLGKLLTHTLEGPSNN VTILQLQDWQDPDSWARTESGLKIYLSQFNSLVQLIYRERKNDVVFPLTVSCSVGCELPPEEGS EPHVFFDVAVNGSAFVSFQPKTAIWVTGSQEPSEAINFTLKQLNTYNRTRYELQEFLQDTCVQY LENHITTQNTKGSQTGRSYTSLVLGILMGCFIIAGVAVGIFLCTGGRRC hide sequence

RefSeq Acc Id:

ENSRNOP00000052129 ⟸ ENSRNOT00000055254

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692588

Promoter ID:

EPDNEW_R3113

Type:

multiple initiation site

Name:

Procr_1

Description:

protein C receptor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	151,285,312 - 151,285,372	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
3	157654138	157654139	G	A	snv	SR/JrHsd (MCW), F344/Jcl (KyushuU), KFRS3B/Kyo (KyushuU), SR/JrHsd (KNAW), SHR/NCrlPrin (KNAW), SHR/NHsd (KNAW), SHR/OlaIpcv (KNAW), SHR/OlaIpcvPrin (KNAW), SHRSP/Gcrc (KNAW), F344/NRrrc (Illumina) (KNAW), WKY/Gcrc (KNAW), WKY/N (KNAW), WKY/NCrl (KNAW), WKY/NHsd (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NCrl (KNAW), F344/NHsd (KNAW), M520/N (KNAW), WN/N (KNAW), SDLEF7/Barth (UDEL), Crl:SD (UDEL), F344/DuCrlCrlj (KyushuU), F344/NSlc (KyushuU), F344/Stm (KyushuU)
3	157654174	157654175	C	T	snv	SBN/Ygl (KNAW), SBN/Ygl (MCW)

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
3	151289003	151289004	G	A	snv	F344/NCrl (RGD), WKY/Gcrc (RGD), SR/JrHsd (MCW), F344/NRrrc (MCW), M520/N (MCW), WKY/N (MCW), WN/N (MCW), WKY/NHsd (RGD), SHR/NHsd (RGD), SHRSP/Gcrc (RGD), SR/JrHsd (RGD), WKY/NCrl (RGD)
3	151289039	151289040	C	T	snv	SBN/Ygl (RGD), SBN/Ygl (MCW)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305991	AgrOrtholog
Ensembl Genes	ENSRNOG00000019330	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000052129	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000055254	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.500.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7445753	IMAGE-MGC_LOAD
	IMAGE:7462042	IMAGE-MGC_LOAD
InterPro	Endothetial_C_recpt	UniProtKB/Swiss-Prot
	MHC_I-like_Ag-recog	UniProtKB/Swiss-Prot
	MHC_I-like_Ag-recog_sf	UniProtKB/Swiss-Prot
	MHC_I/II-like_Ag-recog	UniProtKB/Swiss-Prot
KEGG Report	rno:362248	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:114418	IMAGE-MGC_LOAD
	MGC:116255	IMAGE-MGC_LOAD
NCBI Gene	362248	ENTREZGENE
PANTHER	PTHR15349	UniProtKB/Swiss-Prot
Pfam	MHC_I_3	UniProtKB/Swiss-Prot
PhenoGen	Procr	PhenoGen
Superfamily-SCOP	SSF54452	UniProtKB/Swiss-Prot
UniGene	Rn.144312	ENTREZGENE
UniProt	EPCR_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-23	Procr	protein C receptor	Procr	protein C receptor, endothelial	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Procr	protein C receptor, endothelial	Procr_predicted	protein C receptor, endothelial (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Procr_predicted	protein C receptor, endothelial (predicted)			Symbol and Name status set to approved	70820	APPROVED

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - ClinVar

Imported Annotations - CTD

RGD Manual Annotations