Epas1 (endothelial PAS domain protein 1) - Rat Genome Database

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Gene: Epas1 (endothelial PAS domain protein 1) Rattus norvegicus
Analyze
Symbol: Epas1
Name: endothelial PAS domain protein 1
RGD ID: 68404
Description: Exhibits DNA-binding transcription factor activity and cobalt ion binding activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including norepinephrine biosynthetic process; positive regulation of lung alveolus development; and regulation of cellular biosynthetic process. Localizes to cytoplasm and nucleus. Used to study acute kidney failure and intermittent claudication. Biomarker of artery disease (multiple); glucose metabolism disease (multiple); polycystic kidney disease; and renal cell carcinoma. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1); PARTICIPATES IN hypoxia inducible factor pathway; renal cell carcinoma pathway; INTERACTS WITH 17alpha-ethynylestradiol; 1H-benzimidazole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: endothelial PAS domain-containing protein 1; EPAS-1; HIF-2 alpha; HIF-2-alpha; HIF2 alpha; HIF2-alpha; Hif2a; HLF; hypoxia inducible factor 2, alpha subunit; hypoxia inducible factor 2a; hypoxia-inducible factor 2 alpha; hypoxia-inducible factor 2-alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.267,790,236 - 7,871,246 (-)NCBI
Rnor_6.0 Ensembl610,306,405 - 10,387,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0610,306,508 - 10,385,239 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0620,299,603 - 20,379,864 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4610,203,108 - 10,297,215 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1610,203,107 - 10,297,215 (+)NCBI
Celera67,526,511 - 7,605,382 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
1H-benzimidazole  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydroxybenzoate  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroperoxycyclophosphamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (EXP)
aristolochic acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
Deguelin  (ISO)
delphinidin  (ISO)
desferrioxamine B  (EXP,ISO)
diazinon  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl malate  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (ISO)
galangin  (ISO)
glutathione  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
indoxyl sulfate  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
ketorolac  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
letrozole  (ISO)
LY294002  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mithramycin  (EXP)
myxothiazol  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
panobinostat  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
protoporphyrin  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium cyanide  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
thapsigargin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA,ISO)
nuclear speck  (IEA,ISO)
nucleus  (IDA,ISO)
transcription regulator complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Anderson ER, etal., Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4922-30. doi: 10.1073/pnas.1314197110. Epub 2013 Nov 26.
2. Bai CG, etal., Heart Vessels. 2008 May;23(3):193-200. Epub 2008 May 17.
3. Bernhardt WM, etal., Am J Pathol. 2007 Mar;170(3):830-42.
4. Bernhardt WM, etal., J Am Soc Nephrol. 2006 Jul;17(7):1970-8. Epub 2006 Jun 8.
5. Brown ST, etal., J Neurochem. 2009 Jul;110(2):622-30. Epub 2009 May 8.
6. Gale DP, etal., Blood. 2008 Aug 1;112(3):919-21. doi: 10.1182/blood-2008-04-153718.
7. Garcia-Martin R, etal., Mol Cell Biol. 2015 Nov 16;36(3):376-93. doi: 10.1128/MCB.00430-15.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Giatromanolaki A, etal., Arthritis Res Ther. 2003;5(4):R193-201. Epub 2003 Apr 29.
10. GOA data from the GO Consortium
11. Jurgensen JS, etal., FASEB J. 2004 Sep;18(12):1415-7. Epub 2004 Jul 9.
12. Keith B, etal., Nat Rev Cancer. 2011 Dec 15;12(1):9-22. doi: 10.1038/nrc3183.
13. Kietzmann T, etal., Biochem J 2001 Mar 15;354(Pt 3):531-7.
14. Ladoux A and Frelin C, Biochem Biophys Res Commun 1997 Nov 26;240(3):552-6.
15. Li QF and Dai AG, Acta Biochim Biophys Sin (Shanghai). 2005 Oct;37(10):665-72.
16. Liu MY, etal., Cancer Res. 2003 May 15;63(10):2675-80.
17. Loboda A, etal., Mol Cells. 2010 May;29(5):435-42. Epub 2010 Apr 12.
18. Luo B, etal., Biochim Biophys Acta. 2013 Aug;1832(8):1260-70. doi: 10.1016/j.bbadis.2013.04.015. Epub 2013 Apr 17.
19. Luo JC and Shibuya M, Oncogene. 2001 Mar 22;20(12):1435-44.
20. Miyashita R, etal., Neurosci Lett. 2012 Oct 18;528(1):83-8. doi: 10.1016/j.neulet.2012.08.033. Epub 2012 Aug 28.
21. Nakajima M, etal., J Orthop Res. 2012 Aug;30(8):1244-8. doi: 10.1002/jor.22063. Epub 2012 Jan 13.
22. NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Ohtomo S, etal., Nephrol Dial Transplant. 2008 Apr;23(4):1166-72. Epub 2007 Oct 28.
24. Okamoto N, etal., Cardiovasc Res. 2011 Nov 1;92(2):209-17. doi: 10.1093/cvr/cvr203. Epub 2011 Jul 19.
25. OMIM Disease Annotation Pipeline
26. Park HS, etal., Am J Respir Cell Mol Biol. 2013 Jan;48(1):105-13. doi: 10.1165/rcmb.2012-0043OC. Epub 2012 Oct 11.
27. Pipeline to import KEGG annotations from KEGG into RGD
28. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. Proper SP, etal., Toxicol Sci. 2014 Feb;137(2):447-57. doi: 10.1093/toxsci/kft253. Epub 2013 Nov 11.
30. Rajakumar A, etal., Biol Reprod. 2001 Feb;64(2):499-506.
31. Ramadori P, etal., Liver Int. 2010 Jan;30(1):55-64. doi: 10.1111/j.1478-3231.2009.02131.x. Epub 2009 Oct 13.
32. RGD automated data pipeline
33. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. RGD automated import pipeline for gene-chemical interactions
35. Rosenberger C, etal., J Invest Dermatol. 2007 Oct;127(10):2445-52. Epub 2007 May 10.
36. Rosenberger C, etal., Kidney Int. 2003 Sep;64(3):874-86.
37. Rosenberger C, etal., Kidney Int. 2008 Jan;73(1):34-42. Epub 2007 Oct 3.
38. Ryu JH, etal., Cell Death Differ. 2012 Mar;19(3):440-50. doi: 10.1038/cdd.2011.111. Epub 2011 Aug 26.
39. Saito T, etal., Nat Med. 2010 Jun;16(6):678-86. doi: 10.1038/nm.2146. Epub 2010 May 23.
40. Santana-Rodriguez N, etal., J Heart Lung Transplant. 2012 Feb;31(2):213-21. doi: 10.1016/j.healun.2011.11.011.
41. Schietke RE, etal., PLoS One. 2012;7(1):e31034. doi: 10.1371/journal.pone.0031034. Epub 2012 Jan 27.
42. Schnell PO, etal., J Neurochem 2003 Apr;85(2):483-91.
43. Scortegagna M, etal., Blood. 2003 Sep 1;102(5):1634-40. Epub 2003 May 15.
44. Scortegagna M, etal., Nat Genet 2003 Dec;35(4):331-40. Epub 2003 Nov 9.
45. Skubutyte R, etal., Arthritis Rheum. 2010 Sep;62(9):2707-15.
46. Tanaka T, etal., J Mol Cell Cardiol. 2002 Jul;34(7):739-48.
47. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
48. Vadivel A, etal., Am J Respir Cell Mol Biol. 2014 Jan;50(1):96-105. doi: 10.1165/rcmb.2012-0250OC.
49. Xu J, etal., Wilderness Environ Med. 2015 Sep;26(3):288-94. doi: 10.1016/j.wem.2015.01.002. Epub 2015 Mar 16.
50. Yang S, etal., Nat Med. 2010 Jun;16(6):687-93. doi: 10.1038/nm.2153. Epub 2010 May 23.
51. Yu L and Hales CA, BMC Cancer. 2011 Aug 3;11:331. doi: 10.1186/1471-2407-11-331.
52. Yuan Y, etal., Biochem Biophys Res Commun. 2001 Nov 9;288(4):849-54.
Additional References at PubMed
PMID:9000051   PMID:9079689   PMID:9113979   PMID:9576906   PMID:9808618   PMID:10880563   PMID:11573933   PMID:11782478   PMID:12053176   PMID:12464608   PMID:12805361   PMID:12832481  
PMID:14747751   PMID:15261140   PMID:15626745   PMID:15728559   PMID:15851592   PMID:16181639   PMID:16287860   PMID:16507764   PMID:16677454   PMID:16683694   PMID:16760477   PMID:16761101  
PMID:17220275   PMID:17284606   PMID:17322295   PMID:17404621   PMID:17627993   PMID:18072084   PMID:18353899   PMID:18515655   PMID:19035510   PMID:19147445   PMID:19420289   PMID:19461047  
PMID:20005221   PMID:21106323   PMID:21106753   PMID:21346155   PMID:21436314   PMID:21454802   PMID:21546903   PMID:21753061   PMID:21856340   PMID:21987385   PMID:22128145   PMID:22235342  
PMID:22403787   PMID:22970249   PMID:23462283   PMID:23520526   PMID:23610397   PMID:23814049   PMID:24589856   PMID:25283246   PMID:25715026   PMID:26245371   PMID:26993367   PMID:28686686  
PMID:28820398   PMID:29268860   PMID:30344285   PMID:30669752   PMID:31515405   PMID:32146507   PMID:32290638  


Genomics

Comparative Map Data
Epas1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.267,790,236 - 7,871,246 (-)NCBI
Rnor_6.0 Ensembl610,306,405 - 10,387,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0610,306,508 - 10,385,239 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0620,299,603 - 20,379,864 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4610,203,108 - 10,297,215 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1610,203,107 - 10,297,215 (+)NCBI
Celera67,526,511 - 7,605,382 (-)NCBICelera
Cytogenetic Map6q12NCBI
EPAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl246,293,667 - 46,386,697 (+)EnsemblGRCh38hg38GRCh38
GRCh38246,297,407 - 46,386,697 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37246,524,546 - 46,613,836 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36246,378,067 - 46,467,340 (+)NCBINCBI36hg18NCBI36
Build 34246,436,213 - 46,525,486NCBI
Celera246,363,267 - 46,452,583 (+)NCBI
Cytogenetic Map2p21NCBI
HuRef246,262,570 - 46,351,445 (+)NCBIHuRef
CHM1_1246,455,122 - 46,544,416 (+)NCBICHM1_1
Epas1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,061,292 - 87,140,838 (+)NCBIGRCm39mm39
GRCm39 Ensembl1787,061,128 - 87,140,838 (+)Ensembl
GRCm381786,753,864 - 86,833,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1786,753,700 - 86,833,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv371787,153,204 - 87,232,750 (+)NCBIGRCm37mm9NCBIm37
MGSCv361786,662,228 - 86,739,908 (+)NCBImm8
Celera1791,133,927 - 91,214,803 (+)NCBICelera
Cytogenetic Map17E4NCBI
Epas1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544113,244,626 - 13,328,369 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544113,244,626 - 13,328,220 (+)NCBIChiLan1.0ChiLan1.0
EPAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A47,332,286 - 47,421,560 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A47,332,308 - 47,421,560 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A46,403,411 - 46,492,734 (+)NCBIMhudiblu_PPA_v0panPan3
EPAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11048,550,836 - 48,636,776 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1048,551,410 - 48,634,844 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1048,405,643 - 48,491,569 (+)NCBI
ROS_Cfam_1.01049,422,114 - 49,508,080 (+)NCBI
UMICH_Zoey_3.11049,131,051 - 49,216,377 (+)NCBI
UNSW_CanFamBas_1.01049,421,043 - 49,506,595 (+)NCBI
UU_Cfam_GSD_1.01049,603,605 - 49,689,524 (+)NCBI
Epas1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629234,427,139 - 34,510,273 (-)NCBI
SpeTri2.0NW_0049365085,855,748 - 5,938,879 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl394,165,815 - 94,254,079 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1394,167,759 - 94,253,662 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23100,157,832 - 100,211,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPAS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11460,823,110 - 60,912,804 (-)NCBI
ChlSab1.1 Ensembl1460,822,815 - 60,912,785 (-)Ensembl
Vero_WHO_p1.0NW_02366604550,944,448 - 51,034,251 (+)NCBI
Epas1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473827,747,770 - 27,831,213 (+)NCBI

Position Markers
Epas1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.267,817,840 - 7,817,935 (-)MAPPER
Rnor_6.0610,359,742 - 10,359,836NCBIRnor6.0
Rnor_5.0620,352,340 - 20,352,434UniSTSRnor5.0
RGSC_v3.4610,271,730 - 10,271,824UniSTSRGSC3.4
Celera67,552,090 - 7,552,184UniSTS
Cytogenetic Map6q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6123620518Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6125048718Rat
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6135623029Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6135623029Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6135623029Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6135623029Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6135623029Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6141917988Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6142388212Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6142388212Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142388212Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6142388212Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6142388212Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6143665660Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6143665660Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6143665660Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6144015370Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6144570292Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6175623393Rat
8693645Alc31Alcohol consumption QTL 313.70.038drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)613505323600274Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6112039328706721Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112039346120393Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)6112039375023446Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)6616172276002731Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6616172276002731Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)67009971115379601Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6808322221515439Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6808322221515439Rat
8693699Alc37Alcohol consumption QTL 372.60.224drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)6997427722477622Rat
8693690Alc35Alcohol consumption QTL 352.20.606drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)6997427722477622Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)71017386255173862Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:55
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000034991
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3
Medium 3 43 52 41 14 41 8 11 74 35 40 8 8
Low 5 5 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000034991   ⟹   ENSRNOP00000033874
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl610,348,308 - 10,385,213 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080507   ⟹   ENSRNOP00000070697
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl610,306,508 - 10,385,239 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090420   ⟹   ENSRNOP00000075020
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl610,306,405 - 10,387,265 (+)Ensembl
RefSeq Acc Id: NM_023090   ⟹   NP_075578
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.267,792,263 - 7,871,246 (-)NCBI
Rnor_6.0610,306,508 - 10,385,239 (+)NCBI
Rnor_5.0620,299,603 - 20,379,864 (+)NCBI
RGSC_v3.4610,203,108 - 10,297,215 (+)RGD
Celera67,526,511 - 7,605,382 (-)RGD
Sequence:
RefSeq Acc Id: XM_039111846   ⟹   XP_038967774
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.267,790,236 - 7,870,175 (-)NCBI
RefSeq Acc Id: XM_039111847   ⟹   XP_038967775
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.267,792,172 - 7,870,332 (-)NCBI
Protein Sequences
Protein RefSeqs NP_075578 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967774 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967775 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAB96612 (Get FASTA)   NCBI Sequence Viewer  
  EDM02660 (Get FASTA)   NCBI Sequence Viewer  
  Q9JHS1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_075578   ⟸   NM_023090
- Sequence:
RefSeq Acc Id: ENSRNOP00000070697   ⟸   ENSRNOT00000080507
RefSeq Acc Id: ENSRNOP00000075020   ⟸   ENSRNOT00000090420
RefSeq Acc Id: ENSRNOP00000033874   ⟸   ENSRNOT00000034991
RefSeq Acc Id: XP_038967774   ⟸   XM_039111846
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038967775   ⟸   XM_039111847
- Peptide Label: isoform X2
Protein Domains
bHLH   PAC   PAS

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694385
Promoter ID:EPDNEW_R4910
Type:initiation region
Name:Epas1_1
Description:endothelial PAS domain protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0610,306,435 - 10,306,495EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68404 AgrOrtholog
Ensembl Genes ENSRNOG00000021318 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000033874 UniProtKB/TrEMBL
  ENSRNOP00000070697 UniProtKB/TrEMBL
  ENSRNOP00000075020 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034991 UniProtKB/TrEMBL
  ENSRNOT00000080507 UniProtKB/TrEMBL
  ENSRNOT00000090420 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIF-1_TAD_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIF_alpha_subunit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_translocat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_fold_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29452 UniProtKB/Swiss-Prot
NCBI Gene 29452 ENTREZGENE
Pfam HIF-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIF-1a_CTAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Epas1 PhenoGen
PRINTS NCTRNSLOCATR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC231862
TIGRFAMs sensory_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JYL0_RAT UniProtKB/TrEMBL
  A0A0G2K9J6_RAT UniProtKB/TrEMBL
  EPAS1_RAT UniProtKB/Swiss-Prot
  F1M8I5_RAT UniProtKB/TrEMBL
  Q9JHS1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-04-05 Epas1  endothelial PAS domain protein 1  Hif2a  hypoxia inducible factor 2a  Data Merged 737654 APPROVED
2004-09-10 Epas1  endothelial PAS domain protein 1    endothelial PAS domain protein 1   Name updated 1299863 APPROVED
2002-06-10 Hif2a  hypoxia inducible factor 2a      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Epas1  endothelial PAS domain protein 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains protein contains basic helix-loop-helix/ PAS domain 625724
gene_expression expressed in hepatocytes of the perivenous zone of the rat liver 68201
gene_expression expressed in the lung and adult cardiac tissues but not in the neonatal cardiomyocytes 625724
gene_expression RNA expression appears at birth in lung and cardiac tissues and maintained at high levels throughout adult life 625724
gene_homology has 85% identity with 450-1562 bp region of mouse Epas1 625724
gene_physical_interaction forms heterodimeric complex with the aryl hydro-carbon receptor nuclear translocator (ARNT) 625724
gene_physical_interaction interacts with hypoxia sensitive elements 625724
gene_process activates the transcription of hypoxic stress sensitive genes 625724
gene_process involved in activation of the transcription of vascular endothelial growth factor (VEGF) 625724