1,2-dimethylhydrazine decreases expression ISO RGD:68595 6480464 1, 2-Dimethylhydrazine results in decreased expression of EPAS1 mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO RGD:68595 6480464 Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in decreased expression of EPAS1 mRNA] CTD PMID:22206623 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:68595 6480464 [3 more ... CTD PMID:19679656 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of EPAS1 mRNA CTD PMID:17351261 17beta-estradiol multiple interactions ISO RGD:68594 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of EPAS1 mRNA, EGF protein inhibits the reaction [Estradiol results in decreased expression of EPAS1 mRNA] CTD PMID:24758408 , PMID:30165855 17beta-estradiol multiple interactions ISO RGD:68595 6480464 [letrozole results in decreased abundance of Estradiol] which results in decreased expression of EPAS1 mRNA CTD PMID:19620711 17beta-estradiol decreases expression ISO RGD:68594 6480464 Estradiol results in decreased expression of EPAS1 mRNA CTD PMID:24758408 more ... 1H-benzimidazole increases stability EXP 6480464 benzimidazole results in increased stability of EPAS1 protein CTD PMID:23545307 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:68595 6480464 Tetrachlorodibenzodioxin affects the expression of EPAS1 mRNA CTD PMID:16962184 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:68595 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to EPAS1 gene] CTD PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of EPAS1 mRNA CTD PMID:22298810 , PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:68595 6480464 Tetrachlorodibenzodioxin results in decreased expression of EPAS1 mRNA CTD PMID:19933214 , PMID:28213091 2-amino-2-deoxy-D-glucopyranose decreases expression EXP 6480464 Glucosamine results in decreased expression of EPAS1 mRNA CTD PMID:17109745 2-amino-2-deoxy-D-glucopyranose multiple interactions EXP 6480464 Glucosamine inhibits the reaction [IL1B results in increased expression of EPAS1 mRNA], IL1B affects the reaction [Glucosamine results in decreased expression of EPAS1 mRNA] CTD PMID:17109745 2-methylcholine affects expression ISO RGD:68594 6480464 beta-methylcholine affects the expression of EPAS1 mRNA CTD PMID:21179406 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:23196670 3,3',5-triiodo-L-thyronine increases expression ISO RGD:68595 6480464 Triiodothyronine results in increased expression of EPAS1 mRNA CTD PMID:25172293 3,4-dihydroxybenzoate increases expression ISO RGD:68595 6480464 3, 4-dihydroxybenzoate results in increased expression of EPAS1 mRNA CTD PMID:19679656 3,4-dihydroxybenzoate multiple interactions ISO RGD:68595 6480464 [3 more ... CTD PMID:19679656 3-methylcholanthrene multiple interactions ISO RGD:68595 6480464 [Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of EPAS1 mRNA CTD PMID:23519560 3-phenylprop-2-enal increases expression ISO RGD:68594 6480464 cinnamaldehyde results in increased expression of EPAS1 mRNA CTD PMID:19524605 4,4'-diaminodiphenylmethane increases expression ISO RGD:68595 6480464 4, 4'-diaminodiphenylmethane results in increased expression of EPAS1 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol multiple interactions ISO RGD:68595 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Tretinoin] results in decreased expression of EPAS1 mRNA CTD PMID:30951980 4,4'-sulfonyldiphenol increases expression ISO RGD:68595 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of EPAS1 mRNA CTD PMID:30951980 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of EPAS1 mRNA CTD PMID:21346803 4-hydroperoxycyclophosphamide increases expression ISO RGD:68595 6480464 perfosfamide results in increased expression of EPAS1 protein CTD PMID:23251655 4-hydroxy-TEMPO affects localization ISO RGD:68594 6480464 tempol affects the localization of EPAS1 protein CTD PMID:24755467 5-fluorouracil increases expression ISO RGD:68594 6480464 Fluorouracil results in increased expression of EPAS1 mRNA CTD PMID:16557594 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of EPAS1 mRNA CTD PMID:24780913 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of EPAS1 mRNA CTD PMID:31881176 actinomycin D increases stability EXP 6480464 Dactinomycin results in increased stability of EPAS1 protein CTD PMID:23545307 aflatoxin B1 increases methylation ISO RGD:68594 6480464 Aflatoxin B1 results in increased methylation of EPAS1 gene, Aflatoxin B1 results in increased methylation of EPAS1 intron CTD PMID:27153756 , PMID:30157460 Aflatoxin B2 alpha increases methylation ISO RGD:68594 6480464 aflatoxin B2 results in increased methylation of EPAS1 intron CTD PMID:30157460 aldehydo-D-glucosamine decreases expression EXP 6480464 Glucosamine results in decreased expression of EPAS1 mRNA CTD PMID:17109745 aldehydo-D-glucosamine multiple interactions EXP 6480464 Glucosamine inhibits the reaction [IL1B results in increased expression of EPAS1 mRNA], IL1B affects the reaction [Glucosamine results in decreased expression of EPAS1 mRNA] CTD PMID:17109745 all-trans-retinoic acid increases expression ISO RGD:68594 6480464 Tretinoin results in increased expression of EPAS1 mRNA CTD PMID:15894607 more ... all-trans-retinoic acid multiple interactions ISO RGD:68595 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Tretinoin] results in decreased expression of EPAS1 mRNA CTD PMID:30951980 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of EPAS1 mRNA CTD PMID:16483693 antimycin A multiple interactions EXP 6480464 Antimycin A inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:18353899 aristolochic acid increases expression ISO RGD:68594 6480464 aristolochic acid I results in increased expression of EPAS1 protein CTD PMID:21554934 aristolochic acid decreases expression ISO RGD:68594 6480464 aristolochic acid I results in decreased expression of EPAS1 mRNA CTD PMID:33212167 atrazine decreases expression ISO RGD:68594 6480464 Atrazine results in decreased expression of EPAS1 mRNA CTD PMID:22378314 benzo[a]pyrene decreases expression ISO RGD:68595 6480464 Benzo(a)pyrene results in decreased expression of EPAS1 mRNA CTD PMID:19770486 , PMID:22228805 benzo[a]pyrene increases methylation ISO RGD:68595 6480464 Benzo(a)pyrene results in increased methylation of EPAS1 intron CTD PMID:27901495 benzo[a]pyrene decreases expression ISO RGD:68594 6480464 Benzo(a)pyrene results in decreased expression of EPAS1 mRNA CTD PMID:30453624 benzo[a]pyrene increases expression ISO RGD:68595 6480464 Benzo(a)pyrene results in increased expression of EPAS1 mRNA CTD PMID:22228805 , PMID:23735875 benzo[a]pyrene affects response to substance ISO RGD:68594 6480464 EPAS1 protein affects the susceptibility to Benzo(a)pyrene CTD PMID:23333640 benzo[a]pyrene diol epoxide I increases expression ISO RGD:68594 6480464 7 more ... CTD PMID:20382639 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:68594 6480464 7 more ... CTD PMID:19150397 beta-D-glucosamine decreases expression EXP 6480464 Glucosamine results in decreased expression of EPAS1 mRNA CTD PMID:17109745 beta-D-glucosamine multiple interactions EXP 6480464 Glucosamine inhibits the reaction [IL1B results in increased expression of EPAS1 mRNA], IL1B affects the reaction [Glucosamine results in decreased expression of EPAS1 mRNA] CTD PMID:17109745 bis(2-chloroethyl) sulfide increases expression ISO RGD:68595 6480464 Mustard Gas results in increased expression of EPAS1 mRNA CTD PMID:15674843 bis(2-ethylhexyl) phthalate increases expression ISO RGD:68594 6480464 Diethylhexyl Phthalate results in increased expression of EPAS1 mRNA CTD PMID:31163220 bisphenol A decreases expression ISO RGD:68594 6480464 bisphenol A results in decreased expression of EPAS1 mRNA CTD PMID:28711546 bisphenol A multiple interactions ISO RGD:68594 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of EPAS1 gene CTD PMID:31601247 bisphenol A decreases methylation ISO RGD:68594 6480464 bisphenol A results in decreased methylation of EPAS1 gene CTD PMID:31601247 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of EPAS1 mRNA CTD PMID:30816183 bisphenol A affects expression ISO RGD:68594 6480464 bisphenol A affects the expression of EPAS1 mRNA CTD PMID:30903817 bisphenol A increases expression ISO RGD:68594 6480464 bisphenol A results in increased expression of EPAS1 mRNA CTD PMID:29275510 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of EPAS1 gene CTD PMID:28505145 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of EPAS1 mRNA CTD PMID:25181051 Bisphenol B decreases expression ISO RGD:68594 6480464 bisphenol B results in decreased expression of EPAS1 mRNA CTD PMID:28591870 bisphenol F decreases expression ISO RGD:68594 6480464 bisphenol F results in decreased expression of EPAS1 mRNA CTD PMID:28591870 butan-1-ol multiple interactions ISO RGD:68594 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of EPAS1 mRNA CTD PMID:29432896 cadmium dichloride increases methylation EXP 6480464 Cadmium Chloride results in increased methylation of EPAS1 promoter CTD PMID:22457795 cannabidiol decreases methylation ISO RGD:68595 6480464 Cannabidiol results in decreased methylation of EPAS1 gene CTD PMID:33407853 carbon nanotube decreases expression ISO RGD:68595 6480464 Nanotubes more ... CTD PMID:25554681 chloropicrin affects expression ISO RGD:68594 6480464 chloropicrin affects the expression of EPAS1 mRNA CTD PMID:26352163 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of EPAS1 mRNA CTD PMID:18668222 choline multiple interactions ISO RGD:68595 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of EPAS1 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EPAS1 gene CTD PMID:20938992 chromium(6+) affects expression ISO RGD:68595 6480464 chromium hexavalent ion affects the expression of EPAS1 mRNA CTD PMID:28472532 ciglitazone multiple interactions ISO RGD:68594 6480464 [ciglitazone binds to PPARG protein] which results in increased expression of EPAS1 mRNA CTD PMID:16197558 clofibrate decreases expression ISO RGD:68595 6480464 Clofibrate results in decreased expression of EPAS1 mRNA CTD PMID:23811191 cobalt atom multiple interactions ISO RGD:68595 6480464 EPAS1 protein affects the reaction [Cobalt results in increased abundance of Nitric Oxide] CTD PMID:23788631 cobalt atom increases expression EXP 6480464 Cobalt results in increased expression of EPAS1 protein CTD PMID:17967803 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of EPAS1 protein CTD PMID:21558026 , PMID:23545307 cobalt dichloride increases expression ISO RGD:68595 6480464 cobaltous chloride results in increased expression of EPAS1 protein CTD PMID:24503013 cobalt dichloride increases stability ISO RGD:68594 6480464 cobaltous chloride results in increased stability of EPAS1 protein CTD PMID:18515279 cobalt dichloride increases expression ISO RGD:68594 6480464 cobaltous chloride results in increased expression of EPAS1 protein CTD PMID:21036805 more ... cobalt dichloride affects localization ISO RGD:68594 6480464 cobaltous chloride affects the localization of EPAS1 protein CTD PMID:21863063 cobalt dichloride increases response to substance ISO RGD:68594 6480464 EPAS1 protein results in increased susceptibility to cobaltous chloride CTD PMID:25805230 cobalt dichloride multiple interactions EXP 6480464 [AQP1 protein results in increased stability of EPAS1 protein] promotes the reaction [cobaltous chloride results in increased expression of EPAS1 protein] more ... CTD PMID:23545307 cobalt dichloride multiple interactions ISO RGD:68594 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein] more ... CTD PMID:21863063 more ... copper atom multiple interactions ISO RGD:68595 6480464 EPAS1 gene mutant form inhibits the reaction [Copper deficiency results in increased expression of CYBRD1 mRNA] more ... CTD PMID:23555700 copper atom multiple interactions ISO RGD:68594 6480464 [Chelating Agents binds to Copper] which results in increased expression of EPAS1 mRNA CTD PMID:30911355 copper atom increases expression EXP 6480464 Copper results in increased expression of EPAS1 mRNA CTD PMID:30556269 copper atom increases expression ISO RGD:68595 6480464 Copper deficiency results in increased expression of EPAS1 protein CTD PMID:23555700 copper(0) multiple interactions ISO RGD:68595 6480464 EPAS1 gene mutant form inhibits the reaction [Copper deficiency results in increased expression of CYBRD1 mRNA] more ... CTD PMID:23555700 copper(0) multiple interactions ISO RGD:68594 6480464 [Chelating Agents binds to Copper] which results in increased expression of EPAS1 mRNA CTD PMID:30911355 copper(0) increases expression EXP 6480464 Copper results in increased expression of EPAS1 mRNA CTD PMID:30556269 copper(0) increases expression ISO RGD:68595 6480464 Copper deficiency results in increased expression of EPAS1 protein CTD PMID:23555700 copper(II) sulfate increases expression ISO RGD:68594 6480464 Copper Sulfate results in increased expression of EPAS1 mRNA CTD PMID:19549813 crocidolite asbestos increases expression ISO RGD:68594 6480464 Asbestos, Crocidolite results in increased expression of EPAS1 mRNA CTD PMID:18687144 curcumin multiple interactions ISO RGD:68594 6480464 Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:20554536 cycloheximide multiple interactions ISO RGD:68594 6480464 Cycloheximide inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein], Cycloheximide inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:23958427 cyclosporin A decreases expression ISO RGD:68594 6480464 Cyclosporine results in decreased expression of EPAS1 mRNA CTD PMID:20106945 , PMID:27989131 cyclosporin A increases expression ISO RGD:68594 6480464 Cyclosporine results in increased expression of EPAS1 mRNA CTD PMID:25562108 cyclosporin A decreases expression ISO RGD:68595 6480464 Cyclosporine results in decreased expression of EPAS1 mRNA CTD PMID:19770486 DDT decreases expression EXP 6480464 DDT results in decreased expression of EPAS1 mRNA CTD PMID:30207508 deguelin decreases expression ISO RGD:68594 6480464 deguelin results in decreased expression of EPAS1 protein CTD PMID:19336726 delphinidin multiple interactions ISO RGD:68594 6480464 delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of EPAS1 protein] CTD PMID:18603805 desferrioxamine B multiple interactions ISO RGD:68594 6480464 Deferoxamine inhibits the reaction [EPAS1 protein results in increased degradation of COX4I1 protein] CTD PMID:18515279 desferrioxamine B increases expression EXP 6480464 Deferoxamine results in increased expression of EPAS1 protein CTD PMID:18353899 , PMID:21558026 desferrioxamine B increases expression ISO RGD:68594 6480464 Deferoxamine results in increased expression of EPAS1 protein CTD PMID:27287256 desferrioxamine B increases stability ISO RGD:68594 6480464 Deferoxamine results in increased stability of EPAS1 protein CTD PMID:18515279 diazinon increases methylation ISO RGD:68594 6480464 Diazinon results in increased methylation of EPAS1 gene CTD PMID:22964155 diclofenac decreases expression ISO RGD:68594 6480464 Diclofenac results in decreased expression of EPAS1 protein CTD PMID:12912967 dicrotophos increases expression ISO RGD:68594 6480464 dicrotophos results in increased expression of EPAS1 mRNA CTD PMID:28302478 diethyl malate affects expression ISO RGD:68595 6480464 diethyl malate affects the expression of EPAS1 mRNA CTD PMID:24814887 dinophysistoxin 1 increases expression ISO RGD:68594 6480464 dinophysistoxin 1 results in increased expression of EPAS1 mRNA CTD PMID:28939011 dioxygen multiple interactions ISO RGD:68594 6480464 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1 more ... CTD PMID:20046830 more ... dioxygen increases expression ISO RGD:68595 6480464 Oxygen deficiency results in increased expression of EPAS1 protein CTD PMID:24503013 , PMID:26723917 dioxygen affects localization ISO RGD:68594 6480464 Oxygen deficiency affects the localization of EPAS1 protein CTD PMID:24755467 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of EPAS1 protein CTD PMID:18353899 , PMID:23545307 dioxygen increases expression ISO RGD:68594 6480464 Oxygen deficiency results in increased expression of EPAS1 mRNA, Oxygen deficiency results in increased expression of EPAS1 protein CTD PMID:20554536 more ... dioxygen multiple interactions ISO RGD:68595 6480464 Oxygen deficiency affects the localization of and results in increased activity of EPAS1 protein CTD PMID:20880076 dioxygen affects response to substance EXP 6480464 EPAS1 protein affects the susceptibility to Oxygen deficiency CTD PMID:12679337 dioxygen multiple interactions EXP 6480464 [AQP1 protein results in increased stability of EPAS1 protein] promotes the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] more ... CTD PMID:12679337 more ... disodium selenite increases expression ISO RGD:68594 6480464 Sodium Selenite results in increased expression of EPAS1 mRNA CTD PMID:24383545 dorsomorphin multiple interactions ISO RGD:68594 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:68595 6480464 Doxorubicin results in decreased expression of EPAS1 mRNA CTD PMID:26873546 doxorubicin decreases expression ISO RGD:68594 6480464 Doxorubicin results in decreased expression of EPAS1 mRNA CTD PMID:29803840 ethanol multiple interactions ISO RGD:68594 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of EPAS1 mRNA CTD PMID:29432896 ethanol increases expression ISO RGD:68595 6480464 Ethanol results in increased expression of EPAS1 mRNA CTD PMID:30319688 ethanol affects splicing ISO RGD:68595 6480464 Ethanol affects the splicing of EPAS1 mRNA CTD PMID:30319688 fenamidone increases expression ISO RGD:68595 6480464 fenamidone results in increased expression of EPAS1 mRNA CTD PMID:27029645 flutamide increases expression EXP 6480464 Flutamide results in increased expression of EPAS1 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:68595 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of EPAS1 mRNA more ... CTD PMID:20938992 , PMID:22206623 fulvestrant multiple interactions ISO RGD:68594 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of EPAS1 gene CTD PMID:31601247 furan increases expression ISO RGD:68595 6480464 furan results in increased expression of EPAS1 mRNA CTD PMID:24183702 galangin multiple interactions ISO RGD:68594 6480464 ferrous sulfate inhibits the reaction [galangin results in increased expression of EPAS1 protein], Iron inhibits the reaction [galangin results in increased expression of EPAS1 protein] CTD PMID:17973296 galangin increases expression ISO RGD:68594 6480464 galangin results in increased expression of EPAS1 protein CTD PMID:17973296 glutathione multiple interactions ISO RGD:68594 6480464 Glutathione inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein], Glutathione inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:23958427 hydralazine multiple interactions ISO RGD:68594 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of EPAS1 mRNA CTD PMID:17183730 hydrogen peroxide multiple interactions ISO RGD:68594 6480464 delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of EPAS1 protein] CTD PMID:18603805 hydrogen peroxide increases expression ISO RGD:68594 6480464 Hydrogen Peroxide results in increased expression of EPAS1 protein CTD PMID:18603805 hydrogen peroxide affects expression ISO RGD:68594 6480464 Hydrogen Peroxide affects the expression of EPAS1 mRNA CTD PMID:20044591 ibuprofen decreases expression ISO RGD:68594 6480464 Ibuprofen results in decreased expression of EPAS1 protein CTD PMID:12912967 indoxyl sulfate multiple interactions ISO RGD:68594 6480464 Indican inhibits the reaction [cobaltous chloride affects the localization of EPAS1 protein] CTD PMID:21863063 iron atom multiple interactions ISO RGD:68594 6480464 Iron inhibits the reaction [galangin results in increased expression of EPAS1 protein], Iron inhibits the reaction [Quercetin results in increased expression of EPAS1 protein] CTD PMID:17973296 iron atom increases expression EXP 6480464 Iron deficiency results in increased expression of EPAS1 protein CTD PMID:23814049 iron(0) multiple interactions ISO RGD:68594 6480464 Iron inhibits the reaction [galangin results in increased expression of EPAS1 protein], Iron inhibits the reaction [Quercetin results in increased expression of EPAS1 protein] CTD PMID:17973296 iron(0) increases expression EXP 6480464 Iron deficiency results in increased expression of EPAS1 protein CTD PMID:23814049 iron(2+) sulfate (anhydrous) multiple interactions ISO RGD:68594 6480464 ferrous sulfate inhibits the reaction [galangin results in increased expression of EPAS1 protein], ferrous sulfate inhibits the reaction [Quercetin results in increased expression of EPAS1 protein] CTD PMID:17973296 ketorolac decreases expression ISO RGD:68594 6480464 Ketorolac results in decreased expression of EPAS1 protein CTD PMID:12912967 L-ascorbic acid multiple interactions ISO RGD:68594 6480464 Ascorbic Acid inhibits the reaction [nickel sulfate results in increased expression of EPAS1 protein] CTD PMID:16288478 L-methionine multiple interactions ISO RGD:68595 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of EPAS1 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EPAS1 gene CTD PMID:20938992 leflunomide increases expression ISO RGD:68594 6480464 leflunomide results in increased expression of EPAS1 mRNA CTD PMID:28988120 letrozole multiple interactions ISO RGD:68595 6480464 [letrozole results in decreased abundance of Estradiol] which results in decreased expression of EPAS1 mRNA CTD PMID:19620711 LY294002 multiple interactions ISO RGD:68594 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:23958427 manganese(II) chloride increases expression ISO RGD:68595 6480464 manganese chloride results in increased expression of EPAS1 mRNA CTD PMID:17467022 menadione affects expression ISO RGD:68594 6480464 Vitamin K 3 affects the expression of EPAS1 mRNA CTD PMID:20044591 mercury dibromide increases expression ISO RGD:68594 6480464 mercuric bromide results in increased expression of EPAS1 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:68594 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA CTD PMID:27188386 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of EPAS1 mRNA CTD PMID:32035215 methotrexate increases expression ISO RGD:68594 6480464 Methotrexate results in increased expression of EPAS1 mRNA CTD PMID:17400583 methyl methanesulfonate increases expression ISO RGD:68594 6480464 Methyl Methanesulfonate results in increased expression of EPAS1 mRNA CTD PMID:23649840 mithramycin decreases expression EXP 6480464 Plicamycin results in decreased expression of EPAS1 mRNA CTD PMID:23814049 myxothiazol multiple interactions EXP 6480464 myxothiazol inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:18353899 N-acetyl-L-cysteine multiple interactions ISO RGD:68594 6480464 Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein], Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:23958427 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP3 protein results in increased stability of EPAS1 protein]], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP5 protein results in increased stability of EPAS1 protein]] CTD PMID:23545307 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases stability EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased stability of EPAS1 protein CTD PMID:23545307 N-methyl-4-phenylpyridinium decreases expression ISO RGD:68594 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of EPAS1 mRNA CTD PMID:25234470 N-methyl-4-phenylpyridinium increases expression ISO RGD:68594 6480464 1-Methyl-4-phenylpyridinium results in increased expression of EPAS1 mRNA CTD PMID:25234470 nickel atom multiple interactions ISO RGD:68595 6480464 EPAS1 protein affects the reaction [Nickel results in increased abundance of Nitric Oxide] CTD PMID:23788631 nickel sulfate increases stability ISO RGD:68594 6480464 nickel sulfate results in increased stability of EPAS1 protein CTD PMID:20046830 nickel sulfate multiple interactions ISO RGD:68594 6480464 [HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in decreased expression of USP28 protein] more ... CTD PMID:16288478 , PMID:20046830 nickel sulfate increases expression ISO RGD:68594 6480464 nickel sulfate results in increased expression of EPAS1 mRNA, nickel sulfate results in increased expression of EPAS1 protein CTD PMID:16288478 , PMID:22714537 nitric oxide multiple interactions ISO RGD:68595 6480464 EPAS1 protein affects the reaction [Cobalt results in increased abundance of Nitric Oxide], EPAS1 protein affects the reaction [Nickel results in increased abundance of Nitric Oxide] CTD PMID:23788631 nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of EPAS1 mRNA CTD PMID:20638522 Nor-9-carboxy-delta9-THC multiple interactions ISO RGD:68594 6480464 [Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which affects the methylation of EPAS1 gene CTD PMID:30521419 ochratoxin A multiple interactions ISO RGD:68594 6480464 EPAS1 protein inhibits the reaction [ochratoxin A results in decreased expression of VEGFA protein] CTD PMID:21554934 ochratoxin A decreases expression ISO RGD:68594 6480464 ochratoxin A results in decreased expression of EPAS1 protein CTD PMID:21554934 okadaic acid increases expression ISO RGD:68594 6480464 Okadaic Acid results in increased expression of EPAS1 mRNA CTD PMID:28939011 panobinostat increases expression ISO RGD:68594 6480464 panobinostat results in increased expression of EPAS1 mRNA CTD PMID:26272509 panobinostat multiple interactions ISO RGD:68594 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA CTD PMID:27188386 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of EPAS1 mRNA CTD PMID:33387578 phenylephrine decreases expression EXP 6480464 Phenylephrine results in decreased expression of EPAS1 mRNA CTD PMID:18158353 phenylmercury acetate increases expression ISO RGD:68594 6480464 Phenylmercuric Acetate results in increased expression of EPAS1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:68594 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA CTD PMID:27188386 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:68595 6480464 [Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of EPAS1 mRNA CTD PMID:23519560 phosphane increases expression EXP 6480464 phosphine results in increased expression of EPAS1 mRNA CTD PMID:34427094 pirinixic acid increases expression ISO RGD:68595 6480464 pirinixic acid results in increased expression of EPAS1 mRNA CTD PMID:17426115 , PMID:18301758 piroxicam decreases expression ISO RGD:68594 6480464 Piroxicam results in decreased expression of EPAS1 mRNA CTD PMID:21858171 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:68595 6480464 Pregnenolone Carbonitrile results in increased expression of EPAS1 mRNA CTD PMID:28903501 protoporphyrin affects localization ISO RGD:68594 6480464 protoporphyrin IX affects the localization of EPAS1 protein CTD PMID:23624237 quercetin multiple interactions ISO RGD:68594 6480464 ferrous sulfate inhibits the reaction [Quercetin results in increased expression of EPAS1 protein], Iron inhibits the reaction [Quercetin results in increased expression of EPAS1 protein] CTD PMID:17973296 quercetin increases expression ISO RGD:68594 6480464 Quercetin results in increased expression of EPAS1 protein CTD PMID:17973296 quercitrin increases expression ISO RGD:68594 6480464 quercitrin results in increased expression of EPAS1 mRNA CTD PMID:25193878 rifampicin multiple interactions ISO RGD:68594 6480464 [Rifampin co-treated with NR1I2 protein] results in increased expression of EPAS1 mRNA CTD PMID:21127053 rotenone multiple interactions EXP 6480464 Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:18353899 rotenone decreases expression ISO RGD:68594 6480464 Rotenone results in decreased expression of EPAS1 mRNA CTD PMID:29955902 SB 431542 multiple interactions ISO RGD:68594 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide increases expression ISO RGD:68594 6480464 Silicon Dioxide analog results in increased expression of EPAS1 mRNA CTD PMID:25895662 silver atom decreases expression ISO RGD:68595 6480464 Silver results in decreased expression of EPAS1 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:68595 6480464 Silver results in decreased expression of EPAS1 mRNA CTD PMID:27131904 sodium arsenite multiple interactions ISO RGD:68594 6480464 [MIR182 mRNA affects the susceptibility to sodium arsenite] which affects the expression of EPAS1 mRNA more ... CTD PMID:22662215 more ... sodium arsenite increases expression ISO RGD:68594 6480464 sodium arsenite results in increased expression of EPAS1 mRNA, sodium arsenite results in increased expression of EPAS1 protein CTD PMID:22662215 more ... sodium arsenite affects response to substance ISO RGD:68594 6480464 EPAS1 protein affects the susceptibility to sodium arsenite CTD PMID:23333640 sodium cyanide multiple interactions EXP 6480464 Sodium Cyanide inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:18353899 squalene decreases expression ISO RGD:68594 6480464 Squalene results in decreased expression of EPAS1 mRNA, Squalene results in decreased expression of EPAS1 protein CTD PMID:33219891 sunitinib decreases expression ISO RGD:68594 6480464 Sunitinib results in decreased expression of EPAS1 mRNA CTD PMID:31533062 T-2 toxin multiple interactions ISO RGD:68595 6480464 BAY 11-7085 inhibits the reaction [T-2 Toxin results in increased expression of EPAS1 mRNA], BAY 11-7085 inhibits the reaction [T-2 Toxin results in increased expression of EPAS1 protein] CTD PMID:22800716 T-2 toxin increases expression ISO RGD:68595 6480464 T-2 Toxin results in increased expression of EPAS1 mRNA, T-2 Toxin results in increased expression of EPAS1 protein CTD PMID:22800716 temozolomide decreases expression ISO RGD:68594 6480464 Temozolomide results in decreased expression of EPAS1 mRNA CTD PMID:31758290 thapsigargin decreases expression ISO RGD:68594 6480464 Thapsigargin results in decreased expression of EPAS1 mRNA CTD PMID:22378314 topotecan multiple interactions ISO RGD:68594 6480464 Topotecan inhibits the reaction [sodium arsenite results in increased expression of EPAS1 protein] CTD PMID:30090327 trichloroethene decreases expression ISO RGD:68595 6480464 Trichloroethylene results in decreased expression of EPAS1 mRNA CTD PMID:19448997 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of EPAS1 mRNA CTD PMID:33387578 trichloroethene increases expression ISO RGD:68595 6480464 Trichloroethylene results in increased expression of EPAS1 mRNA CTD PMID:15363585 trichostatin A increases expression ISO RGD:68594 6480464 trichostatin A results in increased expression of EPAS1 mRNA CTD PMID:24935251 more ... trichostatin A multiple interactions ISO RGD:68594 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA CTD PMID:27188386 triptonide increases expression ISO RGD:68595 6480464 triptonide results in increased expression of EPAS1 mRNA CTD PMID:33045310 troglitazone decreases expression ISO RGD:68595 6480464 troglitazone results in decreased expression of EPAS1 mRNA CTD PMID:28973697 tunicamycin decreases expression ISO RGD:68594 6480464 Tunicamycin results in decreased expression of EPAS1 mRNA CTD PMID:22378314 valproic acid multiple interactions ISO RGD:68594 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of EPAS1 mRNA more ... CTD PMID:17183730 , PMID:27188386 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of EPAS1 mRNA CTD PMID:29427782 valproic acid increases expression ISO RGD:68594 6480464 Valproic Acid results in increased expression of EPAS1 mRNA CTD PMID:23179753 more ... valproic acid affects expression ISO RGD:68595 6480464 Valproic Acid affects the expression of EPAS1 mRNA CTD PMID:17292431 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of EPAS1 mRNA CTD PMID:19015723 vinclozolin increases methylation EXP 6480464 vinclozolin results in increased methylation of EPAS1 gene CTD PMID:31079544 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of EPAS1 mRNA CTD PMID:30207508 vorinostat decreases expression ISO RGD:68594 6480464 vorinostat results in decreased expression of EPAS1 mRNA CTD PMID:18769122 zearalenone increases expression ISO RGD:68595 6480464 Zearalenone results in increased expression of EPAS1 mRNA CTD PMID:30138655
