Gene: Epas1 (endothelial PAS domain protein 1) Rattus norvegicus
Symbol: Epas1
Name: endothelial PAS domain protein 1
Description: ENCODES a protein that exhibits cobalt ion binding; DNA binding transcription factor activity; sequence-specific DNA binding; INVOLVED IN cellular response to hypoxia; cellular response to interleukin-1; cellular response to lipopolysaccharide; PARTICIPATES IN hypoxia inducible factor pathway; renal cell cancer pathway; ASSOCIATED WITH Acute Kidney Injury; Brain Injuries; Bronchopulmonary Dysplasia; FOUND IN cytoplasm; nucleus; nuclear speck (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 1H-benzimidazole; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
Also known as: endothelial PAS domain-containing protein 1; EPAS-1; HIF-2 alpha; HIF-2-alpha; HIF2 alpha; HIF2-alpha; Hif2a; HLF; hypoxia inducible factor 2, alpha subunit; hypoxia inducible factor 2a; hypoxia-inducible factor 2 alpha; hypoxia-inducible factor 2-alpha
Homo sapiens (human) : EPAS1 (endothelial PAS domain protein 1)  HGNC  AGR
Mus musculus (house mouse) : Epas1 (endothelial PAS domain protein 1)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Epas1 (endothelial PAS domain protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EPAS1 (endothelial PAS domain protein 1)
Canis lupus familiaris (dog) : EPAS1 (endothelial PAS domain protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Epas1 (endothelial PAS domain protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0610,306,508 - 10,385,239 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0620,299,603 - 20,379,864 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4610,203,108 - 10,297,215 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1610,203,107 - 10,297,215 (+)NCBI
Celera67,526,511 - 7,605,382 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Epas1
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68404
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2017-11-07
Status: ACTIVE