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Gene: Mlkl (mixed lineage kinase domain like pseudokinase) Rattus norvegicus
Symbol: Mlkl
Name: mixed lineage kinase domain like pseudokinase
RGD ID: 1592221
Description: Predicted to have several functions, including ATP binding activity; JUN kinase kinase kinase activity; and identical protein binding activity. Predicted to be involved in several processes, including activation of JUN kinase activity; necroptotic process; and protein homotrimerization. Predicted to localize to cytoplasm; nucleus; and plasma membrane. Orthologous to human MLKL (mixed lineage kinase domain like pseudokinase); INTERACTS WITH 3-chloropropane-1,2-diol; glycerol; 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC690743; mixed lineage kinase domain-like; rCG51567-like; similar to mixed lineage kinase domain-like
Homo sapiens (human) : MLKL (mixed lineage kinase domain like pseudokinase)  HGNC  Alliance
Mus musculus (house mouse) : Mlkl (mixed lineage kinase domain-like)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mlkl (mixed lineage kinase domain like pseudokinase)
Pan paniscus (bonobo/pygmy chimpanzee) : MLKL (mixed lineage kinase domain like pseudokinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mlkl (mixed lineage kinase domain like pseudokinase)
Sus scrofa (pig) : MLKL (mixed lineage kinase domain like pseudokinase)
Chlorocebus sabaeus (African green monkey) : MLKL (mixed lineage kinase domain like pseudokinase)
Heterocephalus glaber (naked mole-rat) : Mlkl (mixed lineage kinase domain like pseudokinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01943,508,416 - 43,535,050 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,506,976 - 43,528,851 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01954,320,076 - 54,341,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41941,232,625 - 41,253,266 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1938,665,695 - 38,691,873 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Mlkl
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1592221
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.