Mlkl (mixed lineage kinase domain like pseudokinase) - Rat Genome Database

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Gene: Mlkl (mixed lineage kinase domain like pseudokinase) Rattus norvegicus
Analyze
Symbol: Mlkl
Name: mixed lineage kinase domain like pseudokinase
RGD ID: 1592221
Description: Predicted to enable ATP binding activity; identical protein binding activity; and protein kinase binding activity. Predicted to be involved in defense response to virus; necroptotic process; and protein homotrimerization. Predicted to be located in several cellular components, including cell junction; cytosol; and nucleus. Orthologous to human MLKL (mixed lineage kinase domain like pseudokinase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; dioxygen.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC690743; mixed lineage kinase domain-like; rCG51567-like; similar to mixed lineage kinase domain-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21939,278,123 - 39,304,555 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1939,276,785 - 39,304,502 (-)Ensembl
Rnor_6.01943,508,416 - 43,535,050 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,506,976 - 43,528,851 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01954,320,076 - 54,341,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41941,232,625 - 41,253,266 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1938,665,695 - 38,691,873 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
atazanavir sulfate  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
Dihydrotanshinone I  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
genistein  (ISO)
glycerol  (EXP)
glycidol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
Pranoprofen  (ISO)
pterostilbene  (ISO)
quetiapine fumarate  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tartrazine  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell junction  (IEA,ISO)
cytoplasm  (ISO)
cytosol  (IEA,ISO)
nucleus  (ISO)
plasma membrane  (ISO)

References

Additional References at PubMed
PMID:22265413   PMID:22265414   PMID:23835476   PMID:24012422   PMID:24095729   PMID:24219132   PMID:24316671   PMID:28289909   PMID:29883610   PMID:29921042   PMID:33879157   PMID:34056794  
PMID:34384567   PMID:34517258  


Genomics

Comparative Map Data
Mlkl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21939,278,123 - 39,304,555 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1939,276,785 - 39,304,502 (-)Ensembl
Rnor_6.01943,508,416 - 43,535,050 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,506,976 - 43,528,851 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01954,320,076 - 54,341,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41941,232,625 - 41,253,266 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1938,665,695 - 38,691,873 (-)NCBICelera
Cytogenetic Map19q12NCBI
MLKL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381674,671,855 - 74,700,862 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1674,671,855 - 74,700,960 (-)EnsemblGRCh38hg38GRCh38
GRCh371674,705,753 - 74,734,760 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361673,263,262 - 73,292,290 (-)NCBINCBI36hg18NCBI36
Build 341673,263,261 - 73,292,290NCBI
Celera1659,005,422 - 59,027,475 (-)NCBI
Cytogenetic Map16q23.1NCBI
HuRef1660,455,333 - 60,484,688 (-)NCBIHuRef
CHM1_11676,117,698 - 76,147,064 (-)NCBICHM1_1
Mlkl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398112,037,879 - 112,065,081 (-)NCBIGRCm39mm39
GRCm39 Ensembl8112,038,429 - 112,064,809 (-)Ensembl
GRCm388111,311,255 - 111,338,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,311,797 - 111,338,177 (-)EnsemblGRCm38mm10GRCm38
MGSCv378113,835,700 - 113,861,803 (-)NCBIGRCm37mm9NCBIm37
MGSCv368114,198,470 - 114,224,876 (-)NCBImm8
Celera8115,538,276 - 115,564,653 (-)NCBICelera
Cytogenetic Map8E1NCBI
Mlkl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554842,796,995 - 2,818,844 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554842,793,092 - 2,819,481 (+)NCBIChiLan1.0ChiLan1.0
MLKL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11674,591,635 - 74,620,689 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1674,591,635 - 74,620,667 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01655,237,656 - 55,266,945 (-)NCBIMhudiblu_PPA_v0panPan3
Mlkl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934935,970,809 - 35,997,628 (+)NCBI
SpeTri2.0NW_00493647523,591,483 - 23,618,152 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MLKL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl612,924,894 - 12,951,173 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1612,923,846 - 12,951,176 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2612,929,733 - 12,938,476 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233145
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1553,005,537 - 53,040,754 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl553,006,101 - 53,040,766 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366632383,909 - 95,109 (-)NCBIVero_WHO_p1.0
Mlkl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474612,193,699 - 12,213,475 (+)NCBIHetGla_female_1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:206
Count of miRNA genes:87
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000036972, ENSRNOT00000074983
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 12 19 1 9 11
Low 43 45 41 41 8 11 64 34 31 8
Below cutoff 10 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001401077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003753111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_597257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_598499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000036972   ⟹   ENSRNOP00000034575
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1939,279,419 - 39,304,502 (-)Ensembl
Rnor_6.0 Ensembl1943,506,976 - 43,528,851 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095360   ⟹   ENSRNOP00000081539
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1939,276,785 - 39,304,471 (-)Ensembl
RefSeq Acc Id: XM_008772570   ⟹   XP_008770792
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21939,278,123 - 39,304,551 (-)NCBI
Rnor_6.01943,508,416 - 43,535,050 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772571   ⟹   XP_008770793
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21939,278,123 - 39,304,551 (-)NCBI
Rnor_6.01943,508,416 - 43,535,050 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772572   ⟹   XP_008770794
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21939,278,123 - 39,304,550 (-)NCBI
Rnor_6.01943,508,416 - 43,535,050 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098249   ⟹   XP_038954177
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21939,278,123 - 39,304,129 (-)NCBI
RefSeq Acc Id: XR_005497027
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21939,278,123 - 39,304,554 (-)NCBI
RefSeq Acc Id: XR_005497028
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21939,287,066 - 39,304,555 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_008770794   ⟸   XM_008772572
- UniProtKB: D3ZKP6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770793   ⟸   XM_008772571
- UniProtKB: D3ZKP6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770792   ⟸   XM_008772570
- UniProtKB: D3ZKP6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034575   ⟸   ENSRNOT00000036972
RefSeq Acc Id: XP_038954177   ⟸   XM_039098249
RefSeq Acc Id: ENSRNOP00000081539   ⟸   ENSRNOT00000095360
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKP6-F1-model_v2 AlphaFold D3ZKP6 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592221 AgrOrtholog
BioCyc Gene G2FUF-5654 BioCyc
Ensembl Genes ENSRNOG00000042353 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000034575 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000081539 ENTREZGENE
Ensembl Transcript ENSRNOT00000036972 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000095360 ENTREZGENE
Gene3D-CATH 1.20.930.20 UniProtKB/TrEMBL
InterPro Adaptor_Cbl_N_dom_sf UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report rno:690743 UniProtKB/TrEMBL
NCBI Gene 690743 ENTREZGENE
Pfam Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Mlkl PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt D3ZKP6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-17 Mlkl  mixed lineage kinase domain like pseudokinase  Mlkl  mixed lineage kinase domain-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Mlkl  mixed lineage kinase domain-like  LOC690743  similar to mixed lineage kinase domain-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC690743  similar to mixed lineage kinase domain-like  LOC687228  similar to mixed lineage kinase domain-like  Data Merged 1643240 APPROVED
2006-11-20 LOC690743  similar to mixed lineage kinase domain-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687228  similar to mixed lineage kinase domain-like      Symbol and Name status set to provisional 70820 PROVISIONAL