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Gene: Mlkl (mixed lineage kinase domain like pseudokinase) Rattus norvegicus
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Symbol: Mlkl
Name: mixed lineage kinase domain like pseudokinase
RGD ID: 1592221
Description: Predicted to have several functions, including ATP binding activity; JUN kinase kinase kinase activity; and identical protein binding activity. Predicted to be involved in several processes, including activation of JUN kinase activity; necroptotic process; and protein homotrimerization. Predicted to localize to cytoplasm; nucleus; and plasma membrane. Orthologous to human MLKL (mixed lineage kinase domain like pseudokinase); INTERACTS WITH 3-chloropropane-1,2-diol; glycerol; 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC690743; mixed lineage kinase domain-like; rCG51567-like; similar to mixed lineage kinase domain-like
Orthologs:
Homo sapiens (human) : MLKL (mixed lineage kinase domain like pseudokinase)  HGNC  Alliance
Mus musculus (house mouse) : Mlkl (mixed lineage kinase domain-like)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mlkl (mixed lineage kinase domain like pseudokinase)
Pan paniscus (bonobo/pygmy chimpanzee) : MLKL (mixed lineage kinase domain like pseudokinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mlkl (mixed lineage kinase domain like pseudokinase)
Sus scrofa (pig) : MLKL (mixed lineage kinase domain like pseudokinase)
Chlorocebus sabaeus (African green monkey) : MLKL (mixed lineage kinase domain like pseudokinase)
Heterocephalus glaber (naked mole-rat) : Mlkl (mixed lineage kinase domain like pseudokinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01943,508,416 - 43,535,050 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,506,976 - 43,528,851 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01954,320,076 - 54,341,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41941,232,625 - 41,253,266 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1938,665,695 - 38,691,873 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Mlkl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1592221
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.