Mlkl (mixed lineage kinase domain like pseudokinase) - Rat Genome Database

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Gene: Mlkl (mixed lineage kinase domain like pseudokinase) Rattus norvegicus
Analyze
Symbol: Mlkl
Name: mixed lineage kinase domain like pseudokinase
RGD ID: 1592221
Description: Predicted to enable ATP binding activity; identical protein binding activity; and protein kinase binding activity. Predicted to be involved in defense response to virus; necroptotic process; and protein homotrimerization. Predicted to be located in several cellular components, including cell junction; cytosol; and nucleus. Predicted to be active in cytoplasm. Orthologous to human MLKL (mixed lineage kinase domain like pseudokinase); INTERACTS WITH 1,3-dichloropropan-2-ol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC690743; mixed lineage kinase domain-like; rCG51567-like; similar to mixed lineage kinase domain-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81956,186,860 - 56,213,886 (-)NCBIGRCr8
mRatBN7.21939,277,526 - 39,304,555 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1939,276,785 - 39,304,502 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1946,082,387 - 46,109,203 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,735,719 - 46,762,536 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01949,035,653 - 49,062,542 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,508,416 - 43,535,050 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,506,976 - 43,528,851 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01954,320,076 - 54,341,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41941,232,625 - 41,253,266 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1938,665,695 - 38,691,873 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
captopril  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
Dihydrotanshinone I  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
galangin  (EXP)
genistein  (ISO)
glycerol  (EXP)
glycidol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
lipopolysaccharide  (ISO)
melatonin  (ISO)
methyl methanesulfonate  (ISO)
minocycline  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
oleic acid  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
Pranoprofen  (ISO)
pterostilbene  (ISO)
quetiapine fumarate  (ISO)
reactive oxygen species  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
SM-164  (ISO)
sodium arsenite  (ISO)
tartrazine  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
tricalcium bis(phosphate)  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell junction  (IEA,ISO)
cytoplasm  (IBA,ISO)
cytosol  (IEA,ISO)
nucleus  (ISO)
plasma membrane  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22265413   PMID:22265414   PMID:23835476   PMID:24012422   PMID:24095729   PMID:24219132   PMID:24316671   PMID:28289909   PMID:29883610   PMID:29921042   PMID:33879157   PMID:34056794  
PMID:34384567   PMID:34517258   PMID:36424866   PMID:36707179   PMID:37904209   PMID:38583954  


Genomics

Comparative Map Data
Mlkl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81956,186,860 - 56,213,886 (-)NCBIGRCr8
mRatBN7.21939,277,526 - 39,304,555 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1939,276,785 - 39,304,502 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1946,082,387 - 46,109,203 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,735,719 - 46,762,536 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01949,035,653 - 49,062,542 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,508,416 - 43,535,050 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,506,976 - 43,528,851 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01954,320,076 - 54,341,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41941,232,625 - 41,253,266 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1938,665,695 - 38,691,873 (-)NCBICelera
Cytogenetic Map19q12NCBI
MLKL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381674,671,855 - 74,700,862 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1674,671,855 - 74,700,960 (-)EnsemblGRCh38hg38GRCh38
GRCh371674,705,753 - 74,734,760 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361673,263,262 - 73,292,290 (-)NCBINCBI36Build 36hg18NCBI36
Build 341673,263,261 - 73,292,290NCBI
Celera1659,005,422 - 59,027,475 (-)NCBICelera
Cytogenetic Map16q23.1NCBI
HuRef1660,455,333 - 60,484,688 (-)NCBIHuRef
CHM1_11676,117,698 - 76,147,064 (-)NCBICHM1_1
T2T-CHM13v2.01680,718,597 - 80,747,927 (-)NCBIT2T-CHM13v2.0
Mlkl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398112,037,879 - 112,065,081 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8112,038,429 - 112,064,809 (-)EnsemblGRCm39 Ensembl
GRCm388111,311,255 - 111,338,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,311,797 - 111,338,177 (-)EnsemblGRCm38mm10GRCm38
MGSCv378113,835,700 - 113,861,803 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368114,198,470 - 114,224,876 (-)NCBIMGSCv36mm8
Celera8115,538,276 - 115,564,653 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map857.98NCBI
Mlkl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554842,796,995 - 2,818,844 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554842,793,092 - 2,819,481 (+)NCBIChiLan1.0ChiLan1.0
MLKL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21884,386,111 - 84,415,455 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11690,308,166 - 90,337,459 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01655,237,656 - 55,266,945 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11674,591,635 - 74,620,689 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1674,591,635 - 74,620,667 (-)Ensemblpanpan1.1panPan2
Mlkl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934935,970,809 - 35,997,628 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647523,591,493 - 23,618,660 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647523,591,483 - 23,618,152 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MLKL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl612,924,894 - 12,951,173 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1612,923,846 - 12,951,176 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2612,929,733 - 12,938,476 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233145
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1553,005,537 - 53,040,754 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl553,006,101 - 53,040,766 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366632383,909 - 95,109 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mlkl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474612,193,699 - 12,213,475 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mlkl
157 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:206
Count of miRNA genes:87
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000036972, ENSRNOT00000074983
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001401077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003753111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010060032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_597257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_598499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000036972   ⟹   ENSRNOP00000034575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1939,279,419 - 39,304,502 (-)Ensembl
Rnor_6.0 Ensembl1943,506,976 - 43,528,851 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095360   ⟹   ENSRNOP00000081539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1939,276,785 - 39,304,471 (-)Ensembl
RefSeq Acc Id: NM_001401077   ⟹   NP_001388006
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,186,860 - 56,213,858 (-)NCBI
mRatBN7.21939,277,526 - 39,304,522 (-)NCBI
RefSeq Acc Id: XM_008772570   ⟹   XP_008770792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,186,899 - 56,213,885 (-)NCBI
mRatBN7.21939,278,123 - 39,304,551 (-)NCBI
Rnor_6.01943,508,416 - 43,535,050 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772571   ⟹   XP_008770793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,186,899 - 56,213,885 (-)NCBI
mRatBN7.21939,278,123 - 39,304,551 (-)NCBI
Rnor_6.01943,508,416 - 43,535,050 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063278293   ⟹   XP_063134363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,186,899 - 56,213,464 (-)NCBI
RefSeq Acc Id: XM_063278294   ⟹   XP_063134364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,186,899 - 56,213,466 (-)NCBI
RefSeq Acc Id: XR_005497028
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,196,406 - 56,213,886 (-)NCBI
mRatBN7.21939,287,066 - 39,304,555 (-)NCBI
RefSeq Acc Id: XR_010060032
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81956,189,542 - 56,213,885 (-)NCBI
RefSeq Acc Id: XP_008770793   ⟸   XM_008772571
- Peptide Label: isoform X1
- UniProtKB: D3ZKP6 (UniProtKB/TrEMBL),   A0A8I5ZV82 (UniProtKB/TrEMBL),   A6IZ87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770792   ⟸   XM_008772570
- Peptide Label: isoform X1
- UniProtKB: D3ZKP6 (UniProtKB/TrEMBL),   A0A8I5ZV82 (UniProtKB/TrEMBL),   A6IZ87 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034575   ⟸   ENSRNOT00000036972
Ensembl Acc Id: ENSRNOP00000081539   ⟸   ENSRNOT00000095360
RefSeq Acc Id: NP_001388006   ⟸   NM_001401077
- UniProtKB: A0A8I5ZV82 (UniProtKB/TrEMBL),   A6IZ87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134364   ⟸   XM_063278294
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZV82 (UniProtKB/TrEMBL),   A6IZ87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134363   ⟸   XM_063278293
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZV82 (UniProtKB/TrEMBL),   A6IZ87 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKP6-F1-model_v2 AlphaFold D3ZKP6 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592221 AgrOrtholog
BioCyc Gene G2FUF-5654 BioCyc
Ensembl Genes ENSRNOG00000042353 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036972.6 UniProtKB/TrEMBL
  ENSRNOT00000095360.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.930.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Adaptor_Cbl_N_dom_sf UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  MLKL_N UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_Kinases-Pseudokinases UniProtKB/TrEMBL
NCBI Gene 690743 ENTREZGENE
PANTHER MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED UniProtKB/TrEMBL
Pfam MLKL_N UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Mlkl PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042353 RatGTEx
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5ZV82 ENTREZGENE, UniProtKB/TrEMBL
  A6IZ87 ENTREZGENE, UniProtKB/TrEMBL
  D3ZKP6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-17 Mlkl  mixed lineage kinase domain like pseudokinase  Mlkl  mixed lineage kinase domain-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Mlkl  mixed lineage kinase domain-like  LOC690743  similar to mixed lineage kinase domain-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC690743  similar to mixed lineage kinase domain-like  LOC687228  similar to mixed lineage kinase domain-like  Data merged from RGD:1587750 1643240 APPROVED
2006-11-20 LOC690743  similar to mixed lineage kinase domain-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687228  similar to mixed lineage kinase domain-like      Symbol and Name status set to provisional 70820 PROVISIONAL