Stk11 (serine/threonine kinase 11) - Rat Genome Database

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Gene: Stk11 (serine/threonine kinase 11) Rattus norvegicus
Analyze
Symbol: Stk11
Name: serine/threonine kinase 11
RGD ID: 1308653
Description: Exhibits protein serine/threonine kinase activity. Involved in several processes, including positive regulation of gluconeogenesis; response to glucagon; and response to thyroid hormone. Localizes to nucleus and protein-containing complex. Colocalizes with Z disc. Biomarker of hyperthyroidism and obesity. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; cervical mucinous adenocarcinoma; endometrial cancer; ovarian carcinoma; and pancreatic cancer. Orthologous to human STK11 (serine/threonine kinase 11); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; mTOR signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 4-hydroxynon-2-enal.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: liver kinase B1 homolog; Lkb1; LOC314621; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; serine/threonine-protein kinase STK11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.279,574,553 - 9,591,315 (-)NCBI
Rnor_6.0 Ensembl712,440,751 - 12,457,513 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0712,440,751 - 12,457,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0712,610,856 - 12,627,616 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,086,760 - 11,103,522 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1711,089,427 - 11,103,113 (-)NCBI
Celera77,750,545 - 7,767,310 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-deoxy-D-glucose  (ISO)
3',5'-cyclic GMP  (ISO)
3-aminobenzamide  (ISO)
3-bromopyruvic acid  (ISO)
4-hydroxynon-2-enal  (EXP)
5-methyltetrahydrofolic acid  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
bleomycin A2  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
choline  (ISO)
cisplatin  (ISO)
corosolic acid  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (EXP)
deoxypodophyllotoxin  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
Gastrodin  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg2  (ISO)
glucose  (ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
L-methionine  (ISO)
lactacystin  (ISO)
lipopolysaccharide  (ISO)
lonidamine  (ISO)
maslinic acid  (ISO)
mechlorethamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
orotic acid  (ISO)
paracetamol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pterostilbene  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rubimaillin  (ISO)
selenium atom  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
tamoxifen  (ISO)
thymoquinone  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO,ISS)
anoikis  (ISO)
autophagy  (IEA)
axonogenesis  (IMP,ISO)
canonical Wnt signaling pathway  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to UV-B  (ISO)
dendrite extension  (ISO)
establishment of cell polarity  (IMP,ISO,ISS)
glucose homeostasis  (ISO,ISS)
Golgi localization  (ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (ISO,ISS)
negative regulation of canonical Wnt signaling pathway  (ISO,ISS)
negative regulation of cell growth  (ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of epithelial cell proliferation involved in prostate gland development  (ISO)
negative regulation of lipid biosynthetic process  (ISO)
negative regulation of TORC1 signaling  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of axonogenesis  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of gluconeogenesis  (IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of vesicle transport along microtubule  (IMP,ISO)
positive thymic T cell selection  (ISO)
protein autophosphorylation  (ISO,ISS)
protein dephosphorylation  (ISO,ISS)
protein phosphorylation  (ISO)
regulation of cell cycle  (ISO)
regulation of cell growth  (ISO,ISS)
regulation of dendrite morphogenesis  (ISO)
regulation of protein kinase B signaling  (ISO)
regulation of Wnt signaling pathway  (ISO)
response to activity  (IEP)
response to glucagon  (IEP)
response to ionizing radiation  (ISO,ISS)
response to lipid  (IDA)
response to peptide hormone  (IEP)
response to thyroid hormone  (IEP)
spermatid development  (ISO)
T cell receptor signaling pathway  (ISO)
TCR signalosome assembly  (ISO)
tissue homeostasis  (ISO)
vasculature development  (ISO,ISS)

Cellular Component
cytoplasm  (ISO,ISS)
cytosol  (ISO,ISS)
membrane  (ISO,ISS)
mitochondrion  (ISO,ISS)
nucleoplasm  (ISO)
nucleus  (IDA,ISO)
protein-containing complex  (IDA)
TCR signalosome  (ISO)
Z disc  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Behunin SM, etal., Arch Biochem Biophys. 2016 Jul 1;601:32-41. doi: 10.1016/j.abb.2016.03.012. Epub 2016 Mar 10.
2. Branvold DJ, etal., J Appl Physiol (1985). 2008 Oct;105(4):1218-27. doi: 10.1152/japplphysiol.00997.2007. Epub 2008 Jul 31.
3. Contreras CM, etal., Cancer Res. 2008 Feb 1;68(3):759-66.
4. Esseghir S, etal., J Pathol. 2006 Dec;210(4):420-30.
5. Fenton H, etal., Appl Immunohistochem Mol Morphol. 2006 Jun;14(2):146-53.
6. GOA data from the GO Consortium
7. Hardie DG J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87.
8. Hawley SA, etal., J Biol. 2003;2(4):28. Epub 2003 Sep 24.
9. Homolya L, etal., PLoS One. 2014 Mar 18;9(3):e91921. doi: 10.1371/journal.pone.0091921. eCollection 2014.
10. Imai K, etal., Biochem Biophys Res Commun. 2006 Dec 22;351(3):595-601. Epub 2006 Oct 18.
11. Kimball SR, etal., J Biol Chem. 2004 Dec 24;279(52):54103-9. Epub 2004 Oct 19.
12. Kuragaki C, etal., Lab Invest. 2003 Jan;83(1):35-45.
13. Lin-Marq N, etal., Mol Genet Genomics. 2005 Apr;273(2):184-96. doi: 10.1007/s00438-005-1124-y. Epub 2005 Feb 25.
14. MGD data from the GO Consortium
15. Nishioka Y, etal., Jpn J Cancer Res. 1999 Jun;90(6):629-32.
16. Noga AA, etal., Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1460-9. Epub 2006 Nov 10.
17. OMIM Disease Annotation Pipeline
18. Pearson HB, etal., Cancer Res. 2008 Apr 1;68(7):2223-32.
19. Pipeline to import KEGG annotations from KEGG into RGD
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. Shan T, etal., Nat Commun. 2016 Jul 27;7:12205. doi: 10.1038/ncomms12205.
23. Shen Z, etal., Clin Cancer Res. 2002 Jul;8(7):2085-90.
24. Sriwijitkamol A, etal., Am J Physiol Endocrinol Metab. 2006 May;290(5):E925-32. Epub 2005 Dec 13.
25. Taylor EB, etal., Am J Physiol Endocrinol Metab. 2004 Dec;287(6):E1082-9. doi: 10.1152/ajpendo.00179.2004. Epub 2004 Aug 3.
26. Watt MJ, etal., J Physiol. 2006 Jul 1;574(Pt 1):139-47. Epub 2006 Apr 27.
Additional References at PubMed
PMID:8910387   PMID:10400995   PMID:11297520   PMID:11430832   PMID:11509733   PMID:11741830   PMID:11853558   PMID:12234250   PMID:12489981   PMID:12805220   PMID:15068958   PMID:16014350  
PMID:16308421   PMID:16428351   PMID:17216128   PMID:17244606   PMID:17482548   PMID:17482549   PMID:18063812   PMID:18311138   PMID:18562309   PMID:18687677   PMID:18774945   PMID:18854309  
PMID:19056867   PMID:19622832   PMID:19892943   PMID:19937189   PMID:20142099   PMID:20203304   PMID:20826460   PMID:21111240   PMID:21378336   PMID:21487392   PMID:21872575   PMID:21994947  
PMID:22124463   PMID:22172813   PMID:23653212   PMID:23831466   PMID:23878245   PMID:24295069   PMID:24367100   PMID:24768298   PMID:25329316   PMID:26167077   PMID:26924458   PMID:27235551  
PMID:29740932   PMID:30198433   PMID:31181335   PMID:31939452  


Genomics

Comparative Map Data
Stk11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.279,574,553 - 9,591,315 (-)NCBI
Rnor_6.0 Ensembl712,440,751 - 12,457,513 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0712,440,751 - 12,457,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0712,610,856 - 12,627,616 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,086,760 - 11,103,522 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1711,089,427 - 11,103,113 (-)NCBI
Celera77,750,545 - 7,767,310 (-)NCBICelera
Cytogenetic Map7q11NCBI
STK11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl191,177,558 - 1,228,435 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl191,177,558 - 1,228,431 (+)EnsemblGRCh38hg38GRCh38
GRCh38191,205,778 - 1,228,431 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37191,205,777 - 1,228,430 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,156,798 - 1,179,434 (+)NCBINCBI36hg18NCBI36
Build 34191,156,797 - 1,179,434NCBI
Celera191,140,029 - 1,162,667 (+)NCBI
Cytogenetic Map19p13.3NCBI
HuRef19981,572 - 1,004,116 (+)NCBIHuRef
CHM1_1191,205,350 - 1,228,397 (+)NCBICHM1_1
Stk11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,951,602 - 79,966,513 (+)NCBIGRCm39mm39
GRCm39 Ensembl1079,951,637 - 79,966,516 (+)Ensembl
GRCm381080,115,767 - 80,130,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,115,803 - 80,130,682 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,579,281 - 79,593,215 (+)NCBIGRCm37mm9NCBIm37
MGSCv361079,519,331 - 79,533,808 (+)NCBImm8
Celera1081,131,368 - 81,145,302 (+)NCBICelera
Cytogenetic Map10C1NCBI
Stk11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,678,195 - 6,699,058 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,678,195 - 6,699,408 (-)NCBIChiLan1.0ChiLan1.0
STK11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1191,188,537 - 1,210,677 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,188,537 - 1,210,677 (+)Ensemblpanpan1.1panPan2
STK11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,558,966 - 57,579,163 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,559,424 - 57,579,118 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,361,634 - 57,381,897 (-)NCBI
ROS_Cfam_1.02058,301,527 - 58,321,790 (-)NCBI
UMICH_Zoey_3.12057,357,343 - 57,377,554 (-)NCBI
UNSW_CanFamBas_1.02057,836,582 - 57,856,814 (-)NCBI
UU_Cfam_GSD_1.02058,039,595 - 58,059,787 (-)NCBI
Stk11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,234,125 - 217,254,944 (-)NCBI
SpeTri2.0NW_004936588579,816 - 601,033 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,230,372 - 77,249,327 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,229,888 - 77,249,322 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,814,541 - 77,823,643 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STK11
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16973,033 - 996,857 (+)NCBI
ChlSab1.1 Ensembl6974,144 - 995,136 (+)Ensembl
Stk11
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248287,444,339 - 7,466,926 (-)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7134147172Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7134828535Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7134828535Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7137009673Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7138119654Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7265313832258115Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7591147750911477Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7595196950951969Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7975804554758045Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)71164710256647102Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71232846767193263Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)712328467106995532Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:154
Count of miRNA genes:113
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000060683
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000060683   ⟹   ENSRNOP00000057414
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,440,751 - 12,457,513 (-)Ensembl
RefSeq Acc Id: NM_001108069   ⟹   NP_001101539
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,574,553 - 9,591,315 (-)NCBI
Rnor_6.0712,440,751 - 12,457,513 (-)NCBI
Rnor_5.0712,610,856 - 12,627,616 (-)NCBI
RGSC_v3.4711,086,760 - 11,103,522 (-)RGD
Celera77,750,545 - 7,767,310 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240910   ⟹   XP_006240972
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,577,221 - 9,591,310 (-)NCBI
Rnor_6.0712,443,419 - 12,457,508 (-)NCBI
Rnor_5.0712,610,856 - 12,627,616 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765096   ⟹   XP_008763318
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,575,315 - 9,591,310 (-)NCBI
Rnor_6.0712,441,513 - 12,457,508 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005486597
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,575,315 - 9,591,310 (-)NCBI
RefSeq Acc Id: XR_005486598
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,577,221 - 9,591,310 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101539 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240972 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763318 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4AE59 (Get FASTA)   NCBI Sequence Viewer  
  EDL89333 (Get FASTA)   NCBI Sequence Viewer  
  EDL89334 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101539   ⟸   NM_001108069
- UniProtKB: A0A0H2UI02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240972   ⟸   XM_006240910
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008763318   ⟸   XM_008765096
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UI02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000057414   ⟸   ENSRNOT00000060683
Protein Domains
Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695034
Promoter ID:EPDNEW_R5558
Type:multiple initiation site
Name:Stk11_2
Description:serine/threonine kinase 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5559  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,456,921 - 12,456,981EPDNEW
RGD ID:13695035
Promoter ID:EPDNEW_R5559
Type:multiple initiation site
Name:Stk11_1
Description:serine/threonine kinase 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5558  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,457,512 - 12,457,572EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308653 AgrOrtholog
Ensembl Genes ENSRNOG00000014287 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000057414 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000060683 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  LKB1_c UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:314621 UniProtKB/Swiss-Prot
NCBI Gene 314621 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Stk11 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0H2UI02 ENTREZGENE
  D4AE59 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A0H2UI02 UniProtKB/Swiss-Prot
  D4A179 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Stk11  serine/threonine kinase 11   Stk11_predicted  serine/threonine kinase 11 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Stk11_predicted  serine/threonine kinase 11 (predicted)      Symbol and Name status set to approved 70820 APPROVED