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Gene: Stk11 (serine/threonine kinase 11) Mus musculus
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Symbol: Stk11
Name: serine/threonine kinase 11
Description: Exhibits LRR domain binding activity; protein kinase activator activity; and protein serine/threonine kinase activity. Involved in several processes, including generation of neurons; positive regulation of protein phosphorylation; and regulation of signal transduction. Localizes to several cellular components, including the TCR signalosome; cytosol; and nucleus. Used to study Peutz-Jeghers syndrome and endometrial cancer. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; cervical mucinous adenocarcinoma; ovarian carcinoma; and pancreatic cancer. Is expressed in several structures, including alimentary system; blood; genitourinary system; lung; and nervous system. Orthologous to human STK11 (serine/threonine kinase 11).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA408040; liver kinase B1 homolog; Lkb1; LKB1 short isoform; mLKB1; Par-4; R75140; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; serine/threonine-protein kinase STK11
Orthologs:
Homo sapiens (human) : STK11 (serine/threonine kinase 11)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Stk11 (serine/threonine kinase 11)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Stk11 (serine/threonine kinase 11)
Pan paniscus (bonobo/pygmy chimpanzee) : STK11 (serine/threonine kinase 11)
Canis lupus familiaris (dog) : STK11 (serine/threonine kinase 11)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Stk11 (serine/threonine kinase 11)
Sus scrofa (pig) : STK11 (serine/threonine kinase 11)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381080,115,767 - 80,130,679 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371079,579,281 - 79,593,215 (+)NCBIGRCm37mm9NCBIm37
MGSCv361079,519,331 - 79,533,808 (+)NCBImm8
Celera1081,130,635 - 81,145,517 (+)NCBICelera
Cytogenetic Map10 C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Stk11
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318549
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.