STK11 (serine/threonine kinase 11) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: STK11 (serine/threonine kinase 11) Pan paniscus
Analyze
Symbol: STK11
Name: serine/threonine kinase 11
RGD ID: 11872896
Description: ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN axonogenesis (ortholog); dendrite extension (ortholog); epithelial cell proliferation involved in prostate gland development (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); B-lymphoblastic leukemia/lymphoma (ortholog); bile duct cancer (ortholog); FOUND IN protein-containing complex (ortholog); serine/threonine protein kinase complex (ortholog); Z disc (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase STK11
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,548,808 - 5,570,145 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,784,506 - 4,806,946 (+)NCBINHGRI_mPanPan1
PanPan1.1191,188,537 - 1,210,677 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,188,537 - 1,210,677 (+)Ensemblpanpan1.1panPan2


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
bile duct cancer  (ISO)
brain cancer  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Cardiomegaly  (ISO)
cerebral creatine deficiency syndrome  (ISO)
cervical mucinous adenocarcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Cronkhite-Canada syndrome  (ISO)
cyclic hematopoiesis  (ISO)
disease of cellular proliferation  (ISO)
Distal Arthrogryposis, with Impaired Proprioception and Touch  (ISO)
dysplastic nevus syndrome  (ISO)
embryonal rhabdomyosarcoma  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
familial adenomatous polyposis  (ISO)
familial adenomatous polyposis 1  (ISO)
familial adenomatous polyposis 2  (ISO)
familial melanoma  (ISO)
genetic disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatoblastoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Insulin Resistance  (ISO)
juvenile polyposis syndrome  (ISO)
Left Ventricular Hypertrophy  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Marfanoid Mental Retardation Syndrome, Autosomal  (ISO)
melanoma  (ISO)
multiple endocrine neoplasia type 1  (ISO)
obesity  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
Pancreatic Neoplasms  (ISO)
Peutz-Jeghers syndrome  (ISO)
prostate carcinoma in situ  (ISO)
skin melanoma  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
testicular cancer  (ISO)
testicular germ cell cancer  (ISO)
Testicular Germ Cell Tumor  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anoikis  (IEA)
axonogenesis  (IEA,ISO)
cellular response to UV-B  (IEA)
dendrite extension  (IEA,ISO)
DNA damage response  (IEA)
epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
establishment of cell polarity  (IEA)
G1 to G0 transition  (IEA,ISO)
glucose homeostasis  (IEA)
Golgi localization  (IEA,ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cell growth  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of cold-induced thermogenesis  (IEA)
negative regulation of epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
negative regulation of TORC1 signaling  (IEA)
positive regulation of autophagy  (IEA)
positive regulation of axonogenesis  (IEA,ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of protein localization to nucleus  (IEA,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IEA)
positive regulation of vesicle transport along microtubule  (IEA)
positive thymic T cell selection  (IEA,ISO)
protein localization to nucleus  (IEA,ISO)
regulation of cell growth  (IEA)
regulation of dendrite morphogenesis  (IEA,ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
regulation of Wnt signaling pathway  (IEA,ISO)
response to activity  (ISO)
response to glucagon  (ISO)
response to ionizing radiation  (IEA)
response to lipid  (ISO)
response to peptide hormone  (ISO)
response to thyroid hormone  (ISO)
signal transduction  (IEA)
spermatid development  (ISO)
T cell receptor signaling pathway  (IEA,ISO)
tissue homeostasis  (IEA,ISO)
vasculature development  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
STK11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,548,808 - 5,570,145 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,784,506 - 4,806,946 (+)NCBINHGRI_mPanPan1
PanPan1.1191,188,537 - 1,210,677 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,188,537 - 1,210,677 (+)Ensemblpanpan1.1panPan2
STK11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,205,778 - 1,228,431 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,177,558 - 1,228,431 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,205,777 - 1,228,430 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,156,798 - 1,179,434 (+)NCBINCBI36Build 36hg18NCBI36
Build 34191,156,797 - 1,179,434NCBI
Celera191,140,029 - 1,162,667 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19981,572 - 1,004,116 (+)NCBIHuRef
CHM1_1191,205,350 - 1,228,397 (+)NCBICHM1_1
T2T-CHM13v2.0191,174,325 - 1,196,989 (+)NCBIT2T-CHM13v2.0
Stk11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,951,602 - 79,966,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,951,637 - 79,966,516 (+)EnsemblGRCm39 Ensembl
GRCm381080,115,767 - 80,130,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,115,803 - 80,130,682 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,579,281 - 79,593,215 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,519,331 - 79,533,808 (+)NCBIMGSCv36mm8
Celera1081,131,368 - 81,145,302 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Stk11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,225,204 - 10,241,965 (-)NCBIGRCr8
mRatBN7.279,574,553 - 9,591,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,575,269 - 9,591,315 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,457,505 - 12,474,280 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,332,844 - 14,349,619 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,193,941 - 12,210,702 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,440,751 - 12,457,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,440,751 - 12,457,513 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,610,856 - 12,627,616 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,086,760 - 11,103,522 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,089,427 - 11,103,113 (-)NCBI
Celera77,750,545 - 7,767,310 (-)NCBICelera
Cytogenetic Map7q11NCBI
Stk11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,678,195 - 6,699,058 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,678,195 - 6,699,408 (-)NCBIChiLan1.0ChiLan1.0
STK11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,558,966 - 57,579,163 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,559,424 - 57,579,118 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,361,634 - 57,381,897 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,301,527 - 58,321,790 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,301,538 - 58,321,845 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,357,343 - 57,377,554 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,836,582 - 57,856,814 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,039,595 - 58,059,787 (-)NCBIUU_Cfam_GSD_1.0
Stk11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,234,125 - 217,254,944 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588579,816 - 603,654 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588579,816 - 601,033 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,230,372 - 77,249,327 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,229,888 - 77,249,322 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,814,541 - 77,823,643 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STK11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16973,033 - 996,857 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6974,144 - 995,136 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660817,866,551 - 7,890,682 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,445,069 - 7,467,298 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,444,339 - 7,466,926 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000065982   ⟹   ENSPPAP00000043048
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl191,188,537 - 1,210,677 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000065983   ⟹   ENSPPAP00000043049
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl191,189,119 - 1,208,904 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000065984   ⟹   ENSPPAP00000043050
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl191,189,119 - 1,192,824 (+)Ensembl
RefSeq Acc Id: XM_008966357   ⟹   XP_008964605
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2205,548,808 - 5,570,145 (+)NCBI
NHGRI_mPanPan1194,784,506 - 4,806,946 (+)NCBI
PanPan1.1191,188,537 - 1,210,677 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008966358   ⟹   XP_008964606
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2205,548,808 - 5,566,041 (+)NCBI
NHGRI_mPanPan1194,784,506 - 4,805,297 (+)NCBI
PanPan1.1191,188,537 - 1,206,232 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024926514   ⟹   XP_024782282
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2205,548,808 - 5,569,714 (+)NCBI
NHGRI_mPanPan1194,784,506 - 4,805,523 (+)NCBI
PanPan1.1191,188,537 - 1,209,794 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063600733   ⟹   XP_063456803
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2205,548,808 - 5,570,145 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008964605   ⟸   XM_008966357
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008964606   ⟸   XM_008966358
- Peptide Label: isoform X4
- UniProtKB: A0A2R9CM47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024782282   ⟸   XM_024926514
- Peptide Label: isoform X3
- UniProtKB: A0A2R9CP11 (UniProtKB/TrEMBL),   A0A2R9CM47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000043048   ⟸   ENSPPAT00000065982
RefSeq Acc Id: ENSPPAP00000043050   ⟸   ENSPPAT00000065984
RefSeq Acc Id: ENSPPAP00000043049   ⟸   ENSPPAT00000065983
RefSeq Acc Id: XP_063456803   ⟸   XM_063600733
- Peptide Label: isoform X2
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000044067 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000065982.1 UniProtKB/TrEMBL
  ENSPPAT00000065983.1 UniProtKB/TrEMBL
  ENSPPAT00000065984.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  LKB1_c UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report pps:100989684 UniProtKB/TrEMBL
NCBI Gene STK11 ENTREZGENE
PANTHER CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE STK11 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9CM33_PANPA UniProtKB/TrEMBL
  A0A2R9CM47 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CP11 ENTREZGENE, UniProtKB/TrEMBL