Enables several functions, including ATP binding activity; magnesium ion binding activity; and p53 binding activity. Involved in several processes, including anoikis; protein phosphorylation; and regulation of signal transduction. Acts upstream of with a negative effect on G1 to G0 transition. Acts upstream of or within activation of protein kinase activity. Located in cytosol; mitochondrion; and nucleoplasm. Part of intracellular protein-containing complex and serine/threonine protein kinase complex. Implicated in Peutz-Jeghers syndrome; cervical mucinous adenocarcinoma; familial melanoma; ovarian carcinoma; and pancreatic cancer. Biomarker of breast carcinoma and endometrial cancer.
4-hydroxy-2-nonenal results in decreased expression of STK11 protein and 4-hydroxy-2-nonenal results in decreased expression of STK11 protein modified form
Glucose results in increased acetylation of and results in decreased activity of STK11 protein and resveratrol inhibits the reaction [Glucose results in increased acetylation of and results in decreased activity of STK11 protein]
Bortezomib inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased expression of and results in decreased phosphorylation of STK11 protein] and Bortezomib inhibits the reaction [geldanamycin results in decreased expression of and results in decreased phosphorylation of STK11 protein]
corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein] and corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]
Glucose results in increased acetylation of and results in decreased activity of STK11 protein and resveratrol inhibits the reaction [Glucose results in increased acetylation of and results in decreased activity of STK11 protein]
dorsomorphin inhibits the reaction [5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]] and dorsomorphin inhibits the reaction [ginsenoside Rg2 results in increased phosphorylation of STK11 protein]
[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of STK11 gene and Folic Acid inhibits the reaction [Dietary Fats results in decreased phosphorylation of STK11 protein]
Bortezomib inhibits the reaction [geldanamycin results in decreased expression of and results in decreased phosphorylation of STK11 protein] and geldanamycin results in decreased expression of and results in decreased phosphorylation of STK11 protein
Glucose results in increased acetylation of and results in decreased activity of STK11 protein and resveratrol inhibits the reaction [Glucose results in increased acetylation of and results in decreased activity of STK11 protein]
STK11 protein promotes the reaction [Histamine results in increased abundance of Cyclic GMP] and STK11 protein promotes the reaction [Histamine results in increased phosphorylation of NOS2 protein]
lactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein]
[Lipopolysaccharides co-treated with formononetin] results in increased phosphorylation of STK11 protein and Quercetin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of STK11 protein]
maslinic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein] and maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased phosphorylation of STK11 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [STK11 mutant form results in increased expression of MYC protein]]
Orotic Acid inhibits the reaction [STK11 protein results in decreased phosphorylation of RPS6KB1 protein] and Orotic Acid inhibits the reaction [STK11 protein results in increased phosphorylation of RPTOR protein]
picroside II inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of STK11 protein] and U 0126 promotes the reaction [picroside II inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of STK11 protein]]
thymoquinone inhibits the reaction [Ethanol results in decreased expression of STK11 protein modified form] and thymoquinone inhibits the reaction [Ethanol results in decreased expression of STK11 protein]