STK11 (serine/threonine kinase 11) - Rat Genome Database

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Gene: STK11 (serine/threonine kinase 11) Sus scrofa
Analyze
Symbol: STK11
Name: serine/threonine kinase 11
RGD ID: 14067591
Description: ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN positive regulation of cellular senescence; activation of protein kinase activity (ortholog); axonogenesis (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); B-lymphoblastic leukemia/lymphoma (ortholog); bile duct cancer (ortholog); FOUND IN cytoplasm (ortholog); protein-containing complex (ortholog); Z disc (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LKB1; serine/threonine-protein kinase STK11
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,230,372 - 77,249,327 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,229,888 - 77,249,322 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,814,541 - 77,823,643 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
bile duct cancer  (ISO)
brain cancer  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Cardiomegaly  (ISO)
cerebral creatine deficiency syndrome  (ISO)
cervical mucinous adenocarcinoma  (ISO)
colon carcinoma  (ISO)
Cronkhite-Canada syndrome  (ISO)
cyclic hematopoiesis  (ISO)
disease of cellular proliferation  (ISO)
Distal Arthrogryposis, with Impaired Proprioception and Touch  (ISO)
dysplastic nevus syndrome  (ISO)
embryonal rhabdomyosarcoma  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
familial adenomatous polyposis  (ISO)
familial adenomatous polyposis 1  (ISO)
familial adenomatous polyposis 2  (ISO)
familial melanoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatoblastoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Insulin Resistance  (ISO)
juvenile polyposis syndrome  (ISO)
Left Ventricular Hypertrophy  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Marfanoid Mental Retardation Syndrome, Autosomal  (ISO)
melanoma  (ISO)
multiple endocrine neoplasia type 1  (ISO)
obesity  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
Pancreatic Neoplasms  (ISO)
Peutz-Jeghers syndrome  (ISO)
prostate carcinoma in situ  (ISO)
skin melanoma  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
testicular cancer  (ISO)
testicular germ cell cancer  (ISO)
Testicular Germ Cell Tumor  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
anoikis  (IEA)
apoptotic process  (IEA)
axonogenesis  (IEA,ISO)
cellular response to UV-B  (IEA)
chromatin remodeling  (IEA)
dendrite extension  (IEA,ISO)
DNA damage response  (IBA,IEA)
epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
establishment of cell polarity  (IBA,IEA)
G1 to G0 transition  (IEA,ISO)
glucose homeostasis  (IEA)
Golgi localization  (IEA,ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cell growth  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of cold-induced thermogenesis  (IEA)
negative regulation of epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
negative regulation of TORC1 signaling  (IEA)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of autophagy  (IEA)
positive regulation of axonogenesis  (IEA,ISO)
positive regulation of cellular senescence  (IMP)
positive regulation of gluconeogenesis  (ISO)
positive regulation of protein localization to nucleus  (IEA,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IEA)
positive regulation of vesicle transport along microtubule  (IBA,IEA)
positive thymic T cell selection  (IEA,ISO)
protein autophosphorylation  (ISO)
protein dephosphorylation  (ISO)
protein localization to nucleus  (IEA,ISO)
protein phosphorylation  (ISO)
regulation of cell growth  (IEA)
regulation of dendrite morphogenesis  (IEA,ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
regulation of Wnt signaling pathway  (IBA,IEA,ISO)
response to activity  (ISO)
response to glucagon  (ISO)
response to ionizing radiation  (IEA)
response to lipid  (ISO)
response to peptide hormone  (ISO)
response to thyroid hormone  (ISO)
signal transduction  (IBA)
spermatid development  (ISO)
T cell receptor signaling pathway  (IEA,ISO)
tissue homeostasis  (IEA,ISO)
vasculature development  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:20203304   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
STK11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,230,372 - 77,249,327 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,229,888 - 77,249,322 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,814,541 - 77,823,643 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STK11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,205,778 - 1,228,431 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,177,558 - 1,228,431 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,205,777 - 1,228,430 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,156,798 - 1,179,434 (+)NCBINCBI36Build 36hg18NCBI36
Build 34191,156,797 - 1,179,434NCBI
Celera191,140,029 - 1,162,667 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19981,572 - 1,004,116 (+)NCBIHuRef
CHM1_1191,205,350 - 1,228,397 (+)NCBICHM1_1
T2T-CHM13v2.0191,174,325 - 1,196,989 (+)NCBIT2T-CHM13v2.0
Stk11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,951,602 - 79,966,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,951,637 - 79,966,516 (+)EnsemblGRCm39 Ensembl
GRCm381080,115,767 - 80,130,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,115,803 - 80,130,682 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,579,281 - 79,593,215 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,519,331 - 79,533,808 (+)NCBIMGSCv36mm8
Celera1081,131,368 - 81,145,302 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Stk11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,225,204 - 10,241,965 (-)NCBIGRCr8
mRatBN7.279,574,553 - 9,591,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,575,269 - 9,591,315 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,457,505 - 12,474,280 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,332,844 - 14,349,619 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,193,941 - 12,210,702 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,440,751 - 12,457,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,440,751 - 12,457,513 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,610,856 - 12,627,616 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,086,760 - 11,103,522 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,089,427 - 11,103,113 (-)NCBI
Celera77,750,545 - 7,767,310 (-)NCBICelera
Cytogenetic Map7q11NCBI
Stk11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,678,195 - 6,699,058 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,678,195 - 6,699,408 (-)NCBIChiLan1.0ChiLan1.0
STK11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,548,808 - 5,570,145 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,784,506 - 4,806,946 (+)NCBINHGRI_mPanPan1
PanPan1.1191,188,537 - 1,210,677 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,188,537 - 1,210,677 (+)Ensemblpanpan1.1panPan2
STK11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,558,966 - 57,579,163 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,559,424 - 57,579,118 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,361,634 - 57,381,897 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,301,527 - 58,321,790 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,301,538 - 58,321,845 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,357,343 - 57,377,554 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,836,582 - 57,856,814 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,039,595 - 58,059,787 (-)NCBIUU_Cfam_GSD_1.0
Stk11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,234,125 - 217,254,944 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588579,816 - 603,654 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588579,816 - 601,033 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16973,033 - 996,857 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6974,144 - 995,136 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660817,866,551 - 7,890,682 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,445,069 - 7,467,298 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,444,339 - 7,466,926 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in STK11
174 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000014673   ⟹   ENSSSCP00000014278
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl277,230,372 - 77,249,327 (-)Ensembl
RefSeq Acc Id: XM_021084263   ⟹   XP_020939922
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1277,229,888 - 77,249,322 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021084265   ⟹   XP_020939924
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1277,232,370 - 77,248,341 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021084266   ⟹   XP_020939925
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1277,232,085 - 77,248,341 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002341711
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1277,229,892 - 77,248,487 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002341712
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1277,229,892 - 77,248,487 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002341713
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1277,229,892 - 77,248,341 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002341714
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1277,229,892 - 77,248,341 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020939922   ⟸   XM_021084263
- Peptide Label: isoform X1
- UniProtKB: A0A8D1ALN4 (UniProtKB/TrEMBL),   F1S6Q9 (UniProtKB/TrEMBL),   A0A4X1VW23 (UniProtKB/TrEMBL),   A0A8D0LRP8 (UniProtKB/TrEMBL),   A0A8D1NB49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020939925   ⟸   XM_021084266
- Peptide Label: isoform X3
- UniProtKB: A0A8D1NB49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020939924   ⟸   XM_021084265
- Peptide Label: isoform X2
- UniProtKB: A0A8D1NB49 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000014278   ⟸   ENSSSCT00000014673
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013429 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015081108 UniProtKB/TrEMBL
  ENSSSCG00025005892 UniProtKB/TrEMBL
  ENSSSCG00030015670 UniProtKB/TrEMBL
  ENSSSCG00035064841 UniProtKB/TrEMBL
  ENSSSCG00040055140 UniProtKB/TrEMBL
  ENSSSCG00045035978 UniProtKB/TrEMBL
  ENSSSCG00050062129 UniProtKB/TrEMBL
  ENSSSCG00055013596 UniProtKB/TrEMBL
  ENSSSCG00060019218 UniProtKB/TrEMBL
  ENSSSCG00065003068 UniProtKB/TrEMBL
  ENSSSCG00070026736 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014673 ENTREZGENE
  ENSSSCT00000014673.4 UniProtKB/TrEMBL
  ENSSSCT00015110574.1 UniProtKB/TrEMBL
  ENSSSCT00025007865.1 UniProtKB/TrEMBL
  ENSSSCT00030021734.1 UniProtKB/TrEMBL
  ENSSSCT00035087295.1 UniProtKB/TrEMBL
  ENSSSCT00040074707.1 UniProtKB/TrEMBL
  ENSSSCT00045061787.1 UniProtKB/TrEMBL
  ENSSSCT00050084629.1 UniProtKB/TrEMBL
  ENSSSCT00055026788.1 UniProtKB/TrEMBL
  ENSSSCT00060025867.1 UniProtKB/TrEMBL
  ENSSSCT00065004052.1 UniProtKB/TrEMBL
  ENSSSCT00070053633.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  LKB1_c UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene STK11 ENTREZGENE
PANTHER CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE STK11 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A4X1VW23 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0LRP8 ENTREZGENE
  A0A8D1ALN4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1NB49 ENTREZGENE, UniProtKB/TrEMBL
  F1S6Q9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:93549 ENTREZGENE