Dusp10 (dual specificity phosphatase 10) - Rat Genome Database

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Gene: Dusp10 (dual specificity phosphatase 10) Rattus norvegicus
Analyze
Symbol: Dusp10
Name: dual specificity phosphatase 10
RGD ID: 1310844
Description: Predicted to enable phosphoprotein phosphatase activity and protein kinase binding activity. Involved in negative regulation of oligodendrocyte differentiation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Biomarker of pancreatitis. Orthologous to human DUSP10 (dual specificity phosphatase 10); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dual specificity protein phosphatase 10; Mkp-5; Mkp5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81398,145,317 - 98,183,304 (+)NCBIGRCr8
mRatBN7.21395,613,716 - 95,651,716 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1395,614,292 - 95,651,716 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1398,119,436 - 98,156,836 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01399,519,471 - 99,556,878 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01396,701,597 - 96,739,011 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013104,284,660 - 104,321,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13104,284,660 - 104,321,455 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013108,932,784 - 108,969,913 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413100,022,421 - 100,059,539 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113100,211,469 - 100,248,572 (+)NCBI
Celera1395,137,681 - 95,175,173 (+)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-bromo-3',5'-cyclic GMP  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
andrographolide  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
boron nitride  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
febuxostat  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
glyphosate  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
N-methylformamide  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
orphenadrine  (EXP)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chromate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IBA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Gobert RP, etal., Mol Cell Biol. 2009 Mar;29(6):1538-53. doi: 10.1128/MCB.01375-08. Epub 2009 Jan 12.
4. Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis. Hofken T, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):680-5.
5. Regulation of MAP kinases by MAP kinase phosphatases. Kondoh K and Nishida E, Biochim Biophys Acta. 2007 Aug;1773(8):1227-37. Epub 2006 Dec 8.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Zhang Y, etal., Nature. 2004 Aug 12;430(7001):793-7.
Additional References at PubMed
PMID:10391943   PMID:16806267   PMID:19696743   PMID:22375048   PMID:22387553   PMID:23874687   PMID:23977283   PMID:24531476   PMID:25772234   PMID:34944046  


Genomics

Comparative Map Data
Dusp10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81398,145,317 - 98,183,304 (+)NCBIGRCr8
mRatBN7.21395,613,716 - 95,651,716 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1395,614,292 - 95,651,716 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1398,119,436 - 98,156,836 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01399,519,471 - 99,556,878 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01396,701,597 - 96,739,011 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013104,284,660 - 104,321,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13104,284,660 - 104,321,455 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013108,932,784 - 108,969,913 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413100,022,421 - 100,059,539 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113100,211,469 - 100,248,572 (+)NCBI
Celera1395,137,681 - 95,175,173 (+)NCBICelera
Cytogenetic Map13q26NCBI
DUSP10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381221,701,424 - 221,742,089 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1221,701,424 - 221,742,089 (-)EnsemblGRCh38hg38GRCh38
GRCh371221,874,766 - 221,915,431 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361219,941,389 - 219,982,084 (-)NCBINCBI36Build 36hg18NCBI36
Celera1195,094,721 - 195,135,415 (-)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1192,550,111 - 192,590,870 (-)NCBIHuRef
CHM1_11223,147,249 - 223,188,013 (-)NCBICHM1_1
T2T-CHM13v2.01220,941,255 - 220,981,921 (-)NCBIT2T-CHM13v2.0
Dusp10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,766,575 - 183,807,833 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,745,499 - 183,807,833 (+)EnsemblGRCm39 Ensembl
GRCm381184,034,381 - 184,075,636 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,013,302 - 184,075,636 (+)EnsemblGRCm38mm10GRCm38
MGSCv371185,858,340 - 185,899,515 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361185,735,717 - 185,776,892 (+)NCBIMGSCv36mm8
Celera1190,994,534 - 191,035,736 (+)NCBICelera
Cytogenetic Map1H5NCBI
cM Map188.2NCBI
Dusp10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555202,339,521 - 2,372,400 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555202,338,548 - 2,371,591 (+)NCBIChiLan1.0ChiLan1.0
DUSP10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2127,661,873 - 27,704,123 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1127,617,737 - 27,666,286 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,293,039 - 197,333,828 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11202,366,333 - 202,407,020 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1202,367,318 - 202,404,720 (-)Ensemblpanpan1.1panPan2
DUSP10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13816,196,354 - 16,233,640 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3816,196,635 - 16,231,315 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3816,250,735 - 16,289,545 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03816,240,595 - 16,279,420 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3816,239,677 - 16,279,370 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13816,247,106 - 16,285,251 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03816,596,161 - 16,634,244 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03816,889,953 - 16,928,100 (-)NCBIUU_Cfam_GSD_1.0
Dusp10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934455,431,439 - 55,471,755 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936650679,647 - 720,038 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936650679,650 - 718,867 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1010,866,448 - 10,905,857 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11010,866,446 - 10,905,852 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21012,978,113 - 13,015,967 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1257,790,969 - 7,833,485 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl257,792,913 - 7,834,346 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660558,050,257 - 8,091,701 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248354,750,077 - 4,782,249 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248354,751,651 - 4,783,916 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dusp10
225 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:81
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000005400
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

Markers in Region
D13Got93  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81398,149,750 - 98,149,912 (+)Marker Load Pipeline
Celera1395,141,973 - 95,142,132UniSTS
RH 3.4 Map13649.8UniSTS
RH 3.4 Map13649.8RGD
RH 2.0 Map13674.3RGD
Cytogenetic Map13q26UniSTS
D13Got91  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21395,630,336 - 95,630,471 (+)MAPPERmRatBN7.2
Rnor_6.013104,300,676 - 104,300,810NCBIRnor6.0
Rnor_5.013108,949,134 - 108,949,268UniSTSRnor5.0
RGSC_v3.413100,038,759 - 100,038,894RGDRGSC3.4
RGSC_v3.413100,038,760 - 100,038,894UniSTSRGSC3.4
RGSC_v3.113100,227,803 - 100,227,937RGD
Celera1395,154,149 - 95,154,283UniSTS
RH 3.4 Map13655.7UniSTS
RH 3.4 Map13655.7RGD
Cytogenetic Map13q26UniSTS
AU046937  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21395,649,838 - 95,650,015 (+)MAPPERmRatBN7.2
Rnor_6.013104,319,579 - 104,319,755NCBIRnor6.0
Rnor_5.013108,968,037 - 108,968,213UniSTSRnor5.0
RGSC_v3.413100,057,663 - 100,057,839UniSTSRGSC3.4
Celera1395,173,297 - 95,173,473UniSTS
Cytogenetic Map13q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000005400   ⟹   ENSRNOP00000005400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1395,614,292 - 95,651,716 (+)Ensembl
Rnor_6.0 Ensembl13104,284,660 - 104,321,455 (+)Ensembl
RefSeq Acc Id: NM_001105734   ⟹   NP_001099204
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81398,145,893 - 98,183,304 (+)NCBI
mRatBN7.21395,614,292 - 95,651,716 (+)NCBI
Rnor_6.013104,284,660 - 104,321,455 (+)NCBI
Rnor_5.013108,932,784 - 108,969,913 (+)NCBI
RGSC_v3.413100,022,421 - 100,059,539 (+)RGD
Celera1395,137,681 - 95,175,173 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091057   ⟹   XP_038946985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81398,145,317 - 98,183,288 (+)NCBI
mRatBN7.21395,613,716 - 95,651,694 (+)NCBI
RefSeq Acc Id: XM_039091058   ⟹   XP_038946986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81398,174,570 - 98,183,288 (+)NCBI
mRatBN7.21395,635,230 - 95,651,694 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099204 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946985 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946986 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94896 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005400.3
RefSeq Acc Id: NP_001099204   ⟸   NM_001105734
- UniProtKB: D3ZBG7 (UniProtKB/TrEMBL),   A6JGP0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005400   ⟸   ENSRNOT00000005400
RefSeq Acc Id: XP_038946985   ⟸   XM_039091057
- Peptide Label: isoform X1
- UniProtKB: D3ZBG7 (UniProtKB/TrEMBL),   A6JGP0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946986   ⟸   XM_039091058
- Peptide Label: isoform X2
Protein Domains
Rhodanese   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZBG7-F1-model_v2 AlphaFold D3ZBG7 1-482 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699096
Promoter ID:EPDNEW_R9621
Type:single initiation site
Name:Dusp10_1
Description:dual specificity phosphatase 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013104,284,665 - 104,284,725EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310844 AgrOrtholog
BioCyc Gene G2FUF-17011 BioCyc
Ensembl Genes ENSRNOG00000004003 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005400.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Dual-sp/Tyr_phosphatase UniProtKB/TrEMBL
  Dual-sp_phosphatase_cat-dom UniProtKB/TrEMBL
  Dual-sp_phosphatase_subgr_cat UniProtKB/TrEMBL
  MAPK_phosph UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Rhodanese-like UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
KEGG Report rno:63995 UniProtKB/TrEMBL
NCBI Gene 63995 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/TrEMBL
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 10 UniProtKB/TrEMBL
Pfam DSPc UniProtKB/TrEMBL
  Rhodanese UniProtKB/TrEMBL
PhenoGen Dusp10 PhenoGen
PRINTS MAPKPHPHTASE UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004003 RatGTEx
SMART DSPc UniProtKB/TrEMBL
  RHOD UniProtKB/TrEMBL
Superfamily-SCOP Rhodanese-like UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt A6JGP0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZBG7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Dusp10  dual specificity phosphatase 10   Dusp10_predicted  dual specificity phosphatase 10 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dusp10_predicted  dual specificity phosphatase 10 (predicted)      Symbol and Name status set to approved 70820 APPROVED