Dusp10 (dual specificity phosphatase 10) - Rat Genome Database

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Gene: Dusp10 (dual specificity phosphatase 10) Heterocephalus glaber
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Symbol: Dusp10
Name: dual specificity phosphatase 10
RGD ID: 18914905
Description: ENCODES a protein that exhibits JUN kinase binding (ortholog); mitogen-activated protein kinase p38 binding (ortholog); phosphatase activity (ortholog); INVOLVED IN dephosphorylation (ortholog); negative regulation of epithelial cell migration (ortholog); negative regulation of epithelial cell proliferation (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); basal cell carcinoma (ortholog); Experimental Autoimmune Encephalomyelitis (ortholog); FOUND IN nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Dual specificity protein phosphatase 10
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248354,751,651 - 4,783,916 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046248354,750,077 - 4,782,249 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleoplasm  (ISO)
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dusp10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248354,751,651 - 4,783,916 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046248354,750,077 - 4,782,249 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
DUSP10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381221,701,424 - 221,742,089 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1221,700,666 - 221,743,169 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371221,874,766 - 221,915,431 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361219,941,389 - 219,982,084 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1195,094,721 - 195,135,415 (-)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1192,550,111 - 192,590,870 (-)NCBIHuRef
CHM1_11223,147,249 - 223,188,013 (-)NCBICHM1_1
T2T-CHM13v2.01220,941,255 - 220,981,921 (-)NCBIT2T-CHM13v2.0
Dusp10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,766,575 - 183,807,833 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,745,499 - 183,807,842 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381184,034,381 - 184,075,636 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,013,302 - 184,075,636 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371185,858,340 - 185,899,515 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361185,735,717 - 185,776,892 (+)NCBIMGSCv36mm8
Celera1190,994,534 - 191,035,736 (+)NCBICelera
Cytogenetic Map1H5NCBI
cM Map188.2NCBI
Dusp10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81398,145,317 - 98,183,304 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1398,145,893 - 98,183,304 (+)EnsemblGRCr8
mRatBN7.21395,613,716 - 95,651,716 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1395,614,292 - 95,651,716 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1398,119,436 - 98,156,836 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01399,519,471 - 99,556,878 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01396,701,597 - 96,739,011 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1397,526,964 - 97,564,370 (+)NCBI
Lyon_Normotensive1397,741,171 - 97,778,572 (+)NCBI
Lyon_Hypertensive1397,671,810 - 97,709,218 (+)NCBI
F344_StmMcwi1397,727,359 - 97,764,764 (+)NCBI
Rnor_6.013104,284,660 - 104,321,455 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13104,284,660 - 104,321,455 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.013108,932,784 - 108,969,913 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.413100,022,421 - 100,059,539 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1395,137,681 - 95,175,173 (+)NCBICelera
RGSC_v3.113100,211,469 - 100,248,572 (+)NCBI
Cytogenetic Map13q26NCBI
Dusp10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555202,339,521 - 2,372,400 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049555202,338,548 - 2,371,591 (+)NCBIChiLan1.0ChiLan1.0
DUSP10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2127,661,873 - 27,704,123 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1127,617,737 - 27,666,286 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,293,039 - 197,333,828 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11202,366,333 - 202,407,020 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1202,367,318 - 202,404,720 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
DUSP10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13816,196,354 - 16,233,640 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3816,196,635 - 16,231,315 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3816,250,735 - 16,289,545 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03816,240,595 - 16,279,420 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3816,239,677 - 16,279,370 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13816,247,106 - 16,285,251 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03816,596,161 - 16,634,244 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03816,889,953 - 16,928,100 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dusp10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11047,914,828 - 47,955,931 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_02440934455,431,439 - 55,471,755 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936650679,647 - 720,038 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936650679,650 - 718,867 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1010,866,448 - 10,905,857 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.11010,866,446 - 10,905,852 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21012,978,113 - 13,015,967 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1257,716,003 - 7,756,145 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_0236660558,050,257 - 8,091,701 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1257,790,969 - 7,833,485 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl257,792,913 - 7,834,346 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Dusp10
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11062,227,600 - 62,264,559 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000027440   ⟹   ENSHGLP00000027199
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248354,750,077 - 4,782,249 (-)Ensembl
RefSeq Acc Id: XM_004867413   ⟹   XP_004867470
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248354,751,651 - 4,783,915 (-)NCBI
RefSeq Acc Id: XM_021246431   ⟹   XP_021102090
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248354,751,651 - 4,783,916 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004867470 (Get FASTA)   NCBI Sequence Viewer  
  XP_021102090 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHA98632 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000027199
GenBank Protein JAO02081 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021102090   ⟸   XM_021246431
- UniProtKB: G5ANM2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004867470   ⟸   XM_004867413
- UniProtKB: G5ANM2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000027199   ⟸   ENSHGLT00000027440


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000019343 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000027440 ENTREZGENE
Gene3D-CATH 3.40.250.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/TrEMBL
  MKP UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/TrEMBL
KEGG Report hgl:101715205 UniProtKB/TrEMBL
NCBI Gene Dusp10 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/TrEMBL
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 10 UniProtKB/TrEMBL
Pfam DSPc UniProtKB/TrEMBL
  Rhodanese UniProtKB/TrEMBL
PRINTS ADSPHPHTASE UniProtKB/TrEMBL
  MAPKPHPHTASE UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/TrEMBL
SMART DSPc UniProtKB/TrEMBL
  RHOD UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
  SSF52821 UniProtKB/TrEMBL
UniProt G5ANM2 ENTREZGENE, UniProtKB/TrEMBL