Dusp10 (dual specificity phosphatase 10) - Rat Genome Database

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Gene: Dusp10 (dual specificity phosphatase 10) Mus musculus
Analyze
Symbol: Dusp10
Name: dual specificity phosphatase 10
RGD ID: 1321980
MGI Page MGI
Description: Enables MAP kinase phosphatase activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of epithelial cell migration; and negative regulation of epithelium regeneration. Acts upstream of or within several processes, including negative regulation of MAPK cascade; negative regulation of respiratory burst involved in inflammatory response; and oligodendrocyte differentiation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human DUSP10 (dual specificity phosphatase 10).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610306G15Rik; AI158871; dual specificity protein phosphatase 10; MAP kinase phosphatase 5; mitogen-activated protein kinase phosphatase 5; MKP; MKP-; MKP-5; MKP5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,766,575 - 183,807,833 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,745,499 - 183,807,833 (+)EnsemblGRCm39 Ensembl
GRCm381184,034,381 - 184,075,636 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,013,302 - 184,075,636 (+)EnsemblGRCm38mm10GRCm38
MGSCv371185,858,340 - 185,899,515 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361185,735,717 - 185,776,892 (+)NCBIMGSCv36mm8
Celera1190,994,534 - 191,035,736 (+)NCBICelera
Cytogenetic Map1H5NCBI
cM Map188.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
1H-pyrazole  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
andrographolide  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
boron nitride  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
febuxostat  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (ISO)
gingerol  (ISO)
glyphosate  (ISO)
isotretinoin  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
leflunomide  (ISO)
mercury dibromide  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (EXP)
N-methylformamide  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
orphenadrine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (EXP)
perfluorononanoic acid  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chromate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IBA,ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2. Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis. Hofken T, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):680-5.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Regulation of MAP kinases by MAP kinase phosphatases. Kondoh K and Nishida E, Biochim Biophys Acta. 2007 Aug;1773(8):1227-37. Epub 2006 Dec 8.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Zhang Y, etal., Nature. 2004 Aug 12;430(7001):793-7.
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11060451   PMID:11076861   PMID:11959861   PMID:12477932   PMID:14681479   PMID:15761153   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:17699753   PMID:18287559   PMID:18554416   PMID:19139271   PMID:19554387   PMID:19696743   PMID:21267068   PMID:21487011   PMID:21533046   PMID:21873635   PMID:22307906   PMID:22683306  
PMID:23543058   PMID:23874687   PMID:23977283   PMID:24154525   PMID:24248350   PMID:24634491   PMID:25615285   PMID:25772234   PMID:25772359   PMID:25922079   PMID:25951516   PMID:26930384  
PMID:28096466   PMID:29047406   PMID:29445242   PMID:30938680   PMID:31483681   PMID:31962332   PMID:32843541   PMID:32998359   PMID:33903225   PMID:34647385   PMID:34782469   PMID:34992607  
PMID:37164190   PMID:37429895  


Genomics

Comparative Map Data
Dusp10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,766,575 - 183,807,833 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,745,499 - 183,807,833 (+)EnsemblGRCm39 Ensembl
GRCm381184,034,381 - 184,075,636 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,013,302 - 184,075,636 (+)EnsemblGRCm38mm10GRCm38
MGSCv371185,858,340 - 185,899,515 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361185,735,717 - 185,776,892 (+)NCBIMGSCv36mm8
Celera1190,994,534 - 191,035,736 (+)NCBICelera
Cytogenetic Map1H5NCBI
cM Map188.2NCBI
DUSP10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381221,701,424 - 221,742,089 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1221,701,424 - 221,742,089 (-)EnsemblGRCh38hg38GRCh38
GRCh371221,874,766 - 221,915,431 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361219,941,389 - 219,982,084 (-)NCBINCBI36Build 36hg18NCBI36
Celera1195,094,721 - 195,135,415 (-)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1192,550,111 - 192,590,870 (-)NCBIHuRef
CHM1_11223,147,249 - 223,188,013 (-)NCBICHM1_1
T2T-CHM13v2.01220,941,255 - 220,981,921 (-)NCBIT2T-CHM13v2.0
Dusp10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81398,145,317 - 98,183,304 (+)NCBIGRCr8
mRatBN7.21395,613,716 - 95,651,716 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1395,614,292 - 95,651,716 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1398,119,436 - 98,156,836 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01399,519,471 - 99,556,878 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01396,701,597 - 96,739,011 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013104,284,660 - 104,321,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13104,284,660 - 104,321,455 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013108,932,784 - 108,969,913 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413100,022,421 - 100,059,539 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113100,211,469 - 100,248,572 (+)NCBI
Celera1395,137,681 - 95,175,173 (+)NCBICelera
Cytogenetic Map13q26NCBI
Dusp10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555202,339,521 - 2,372,400 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555202,338,548 - 2,371,591 (+)NCBIChiLan1.0ChiLan1.0
DUSP10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2127,661,873 - 27,704,123 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1127,617,737 - 27,666,286 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,293,039 - 197,333,828 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11202,366,333 - 202,407,020 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1202,367,318 - 202,404,720 (-)Ensemblpanpan1.1panPan2
DUSP10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13816,196,354 - 16,233,640 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3816,196,635 - 16,231,315 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3816,250,735 - 16,289,545 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03816,240,595 - 16,279,420 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3816,239,677 - 16,279,370 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13816,247,106 - 16,285,251 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03816,596,161 - 16,634,244 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03816,889,953 - 16,928,100 (-)NCBIUU_Cfam_GSD_1.0
Dusp10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934455,431,439 - 55,471,755 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936650679,647 - 720,038 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936650679,650 - 718,867 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1010,866,448 - 10,905,857 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11010,866,446 - 10,905,852 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21012,978,113 - 13,015,967 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1257,790,969 - 7,833,485 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl257,792,913 - 7,834,346 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660558,050,257 - 8,091,701 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248354,750,077 - 4,782,249 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248354,751,651 - 4,783,916 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dusp10
1364 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:803
Count of miRNA genes:491
Interacting mature miRNAs:574
Transcripts:ENSMUST00000048655, ENSMUST00000139839
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147125258188983224Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150193673188359312Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150193673188359312Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150193673188359312Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150756737184756922Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151186243185186402Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined151835111185835280Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152038741186038913Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152038741186038913Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152038741186038913Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152038741186038913Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152038741186038913Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152132744186132744Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152132744186132744Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152794822186438620Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153675990187676105Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153712853187712853Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154410512188410512Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155002940189002940Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155002940189002940Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155002940189002940Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155525623189527533Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155526796189526897Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155582237185994196Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155716221189716369Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155716221189716369Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155716221189716369Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155721528189722608Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1155831765189831892Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined155831765189831892Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1155831765189831892Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1155831765189831892Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156602037189303617Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156602037189303617Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157456299191456436Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157456299191456436Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157456299191456436Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157456299191456436Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157456299191456436Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157456299191456436Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158468817192468938Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158468817192468938Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158468817192468938Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158468817192468938Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158468817192468938Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158468817192468938Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162145207194111528Mouse
1301309Emo1_memotionality 1 (mouse)Not determined1162977097185994196Mouse
1300888Berr1_mberghei resistance locus 1 (mouse)Not determined1164143227190534272Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1165873675195154279Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167462514195154279Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167462514195154279Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167462514195154279Mouse
12792983Liq1_mlimb inflammation QTL 1 (mouse)1167586086191225397Mouse
1301333Mop3_mmorphine preference 3 (mouse)Not determined1167756737189303617Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168213823195154279Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170379500195154279Mouse
4142389Scfr1_mstem cell frequency regulator 1 (mouse)Not determined171632048189303617Mouse
1300727Mptp1_mMPTP sensitivity 1 (mouse)Not determined1171632048192681050Mouse
1357732Tbbmd1_mtotal body bone mineral density 1 (mouse)Not determined1171983110195154279Mouse
11049575Lmr8b_mleishmaniasis resistance 8b (mouse)1172303451195154279Mouse
1301652Cpfd2_mcerebellum pattern fissures (mouse)Not determined1172303451195154279Mouse
10043863Swrl5_mSWR lupus locus 5 (mouse)Not determined1172303451195154279Mouse
12880426V25Dq2_mvitamin D inactive form serum level QTL 2 (mouse)1172532197195154279Mouse
12880429V25Dq1_mvitamin D inactive form serum level QTL 1 (mouse)1172632197195154279Mouse
1302023Orch4_mautoimmune orchitis resistance 4 (mouse)Not determined1175211318195154279Mouse
11532690Sluc37_msusceptibility to lung cancer 37 (mouse)1175468817194111528Mouse
1357692Axtq1_manxiety QTL 1 (mouse)Not determined1180832317191851043Mouse
1357620Aaj1_manxiety in A/J 1 (mouse)Not determined1180832317191851043Mouse

Markers in Region
AI158871  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381184,074,473 - 184,074,586UniSTSGRCm38
MGSCv371185,898,352 - 185,898,465UniSTSGRCm37
Celera1191,034,574 - 191,034,687UniSTS
Cytogenetic Map1H5UniSTS
Whitehead/MRC_RH12295.99UniSTS
Dusp10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H5UniSTS
cM Map1 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006497188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006497189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB037908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC107743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY283666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK626309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000048655   ⟹   ENSMUSP00000045838
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1183,766,578 - 183,807,833 (+)Ensembl
GRCm38.p6 Ensembl1184,034,381 - 184,075,636 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139839   ⟹   ENSMUSP00000121433
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1183,745,499 - 183,769,471 (+)Ensembl
GRCm38.p6 Ensembl1184,013,302 - 184,037,274 (+)Ensembl
RefSeq Acc Id: NM_022019   ⟹   NP_071302
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,766,578 - 183,807,833 (+)NCBI
GRCm381184,034,381 - 184,075,636 (+)NCBI
MGSCv371185,858,340 - 185,899,515 (+)RGD
Celera1190,994,534 - 191,035,736 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006497188   ⟹   XP_006497251
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,767,571 - 183,807,088 (+)NCBI
GRCm381184,035,371 - 184,075,621 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006497189   ⟹   XP_006497252
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,766,820 - 183,807,088 (+)NCBI
GRCm381184,034,625 - 184,075,621 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036152719   ⟹   XP_036008612
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,766,575 - 183,782,409 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_071302   ⟸   NM_022019
- UniProtKB: Q8R3L3 (UniProtKB/Swiss-Prot),   Q9CZY9 (UniProtKB/Swiss-Prot),   Q9ESS0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006497252   ⟸   XM_006497189
- Peptide Label: isoform X1
- UniProtKB: Q8R3L3 (UniProtKB/Swiss-Prot),   Q9CZY9 (UniProtKB/Swiss-Prot),   Q9ESS0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006497251   ⟸   XM_006497188
- Peptide Label: isoform X1
- UniProtKB: Q8R3L3 (UniProtKB/Swiss-Prot),   Q9CZY9 (UniProtKB/Swiss-Prot),   Q9ESS0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000121433   ⟸   ENSMUST00000139839
RefSeq Acc Id: ENSMUSP00000045838   ⟸   ENSMUST00000048655
RefSeq Acc Id: XP_036008612   ⟸   XM_036152719
- Peptide Label: isoform X2
Protein Domains
Rhodanese   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ESS0-F1-model_v2 AlphaFold Q9ESS0 1-483 view protein structure

Promoters
RGD ID:6876006
Promoter ID:EPDNEW_M1454
Type:multiple initiation site
Name:Dusp10_1
Description:Mus musculus dual specificity phosphatase 10 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381184,034,460 - 184,034,520EPDNEW
RGD ID:6817624
Promoter ID:MM_KWN:3199
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000085760
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361185,857,536 - 185,858,472 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1927070 AgrOrtholog
Ensembl Genes ENSMUSG00000039384 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000048655 ENTREZGENE
  ENSMUST00000048655.8 UniProtKB/Swiss-Prot
  ENSMUST00000139839.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot
  3.90.190.10 UniProtKB/Swiss-Prot
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot
  MKP UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  Rhodanese-like_dom UniProtKB/Swiss-Prot
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot
  Tyr_Pase_AS UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot
KEGG Report mmu:63953 UniProtKB/Swiss-Prot
MGD MGI:1927070 ENTREZGENE
NCBI Gene 63953 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 10 UniProtKB/Swiss-Prot
Pfam DSPc UniProtKB/Swiss-Prot
  Rhodanese UniProtKB/Swiss-Prot
PhenoGen Dusp10 PhenoGen
PRINTS ADSPHPHTASE UniProtKB/Swiss-Prot
  MAPKPHPHTASE UniProtKB/Swiss-Prot
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot
SMART DSPc UniProtKB/Swiss-Prot
  RHOD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot
  SSF52821 UniProtKB/Swiss-Prot
UniProt D3Z2S1_MOUSE UniProtKB/TrEMBL
  DUS10_MOUSE UniProtKB/Swiss-Prot
  Q8R3L3 ENTREZGENE
  Q9CZY9 ENTREZGENE
  Q9ESS0 ENTREZGENE
UniProt Secondary Q8R3L3 UniProtKB/Swiss-Prot
  Q9CZY9 UniProtKB/Swiss-Prot