Glrx (glutaredoxin) - Rat Genome Database

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Gene: Glrx (glutaredoxin) Rattus norvegicus
Analyze
Symbol: Glrx
Name: glutaredoxin
RGD ID: 70951
Description: Enables glutathione disulfide oxidoreductase activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of secretion by cell; and regulation of signal transduction. Located in dendrite and neuronal cell body. Biomarker of obesity and transient cerebral ischemia. Orthologous to human GLRX (glutaredoxin); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Glrx1; glutaredoxin (thioltransferase); glutaredoxin 1; glutaredoxin 1 (thioltransferase); glutaredoxin-1; Grx; thioltransferase-1; TTase-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Glrx-ps16   Glrx-ps4   Glrx-ps5   Glrx-ps6   Glrx-ps7  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr827,073,737 - 7,083,548 (+)NCBIGRCr8
mRatBN7.225,341,873 - 5,351,686 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl25,341,885 - 5,351,680 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx212,448,925 - 12,458,659 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0210,548,158 - 10,557,892 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.025,184,459 - 5,194,212 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.022,606,032 - 2,615,944 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl22,605,996 - 2,615,944 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.022,604,479 - 2,614,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.422,888,605 - 2,899,216 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.122,908,046 - 2,918,657 (+)NCBI
Celera21,812,028 - 1,821,780 (+)NCBICelera
Cytogenetic Map2q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimonite  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
Diisodecyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
fenthion  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
folpet  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury dichloride  (ISO)
methimazole  (EXP)
methylene blue  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
PD 0325901  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
propiconazole  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
selenium atom  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrahydropalmatine  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
dendrite  (IDA)
neuronal cell body  (IDA)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Aon-Bertolino ML, etal., Biochim Biophys Acta. 2011 Jan;1810(1):93-110. Epub 2010 Jul 8.
2. Functional glutaredoxin (thioltransferase) activity in rat brain and liver mitochondria. Ehrhart J, etal., Parkinsonism Relat Disord 2002 Sep;8(6):395-400.
3. Glutaredoxin regulates apoptosis in cardiomyocytes via NFkappaB targets Bcl-2 and Bcl-xL: implications for cardiac aging. Gallogly MM, etal., Antioxid Redox Signal. 2010 Jun 15;12(12):1339-53. doi: 10.1089/ars.2009.2791.
4. Aging-dependent changes in rat heart mitochondrial glutaredoxins-Implications for redox regulation. Gao XH, etal., Redox Biol. 2013 Nov 12;1(1):586-98. doi: 10.1016/j.redox.2013.10.010. eCollection 2013.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Expression of glutaredoxin (thioltransferase) in the rat ovary during the oestrous cycle and postnatal development. Gonzalez-Fernandez R, etal., J Mol Endocrinol. 2005 Jun;34(3):625-35.
8. Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase. Kanda M, etal., J Biol Chem. 2006 Sep 29;281(39):28518-28. Epub 2006 Aug 7.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Broccoli: a unique vegetable that protects mammalian hearts through the redox cycling of the thioredoxin superfamily. Mukherjee S, etal., J Agric Food Chem. 2008 Jan 23;56(2):609-17. Epub 2007 Dec 29.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. What is the functional significance of the unique location of glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria? Pai HV, etal., Antioxid Redox Signal. 2007 Nov;9(11):2027-33.
13. S-Glutathionylation of hepatic and visceral adipose proteins decreases in obese rats. Picklo MJ Sr, etal., Obesity (Silver Spring). 2013 Feb;21(2):297-305. doi: 10.1002/oby.20002.
14. Glutaredoxins catalyze the reduction of glutathione by dihydrolipoamide with high efficiency. Porras P, etal., Biochem Biophys Res Commun. 2002 Aug 2;295(5):1046-51.
15. Glutaredoxin-1 mediates NADPH-dependent stimulation of calcium-dependent insulin secretion. Reinbothe TM, etal., Mol Endocrinol. 2009 Jun;23(6):893-900. doi: 10.1210/me.2008-0306. Epub 2009 Mar 19.
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Muller cells: model of diabetic retinopathy. Shelton MD, etal., J Biol Chem. 2007 Apr 27;282(17):12467-74. Epub 2007 Feb 26.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Localization of glutaredoxin (thioltransferase) in the rat brain and possible functional implications during focal ischemia. Takagi Y, etal., Biochem Biophys Res Commun. 1999 May 10;258(2):390-4.
21. 17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells. Urata Y, etal., J Biol Chem. 2006 May 12;281(19):13092-102. Epub 2006 Mar 20.
Additional References at PubMed
PMID:7851394   PMID:11213470   PMID:14522978   PMID:15489334   PMID:15983215   PMID:16884690   PMID:18570454   PMID:18614015   PMID:19074435   PMID:19199708   PMID:19265039   PMID:19542013  
PMID:20175144   PMID:23376485  


Genomics

Comparative Map Data
Glrx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr827,073,737 - 7,083,548 (+)NCBIGRCr8
mRatBN7.225,341,873 - 5,351,686 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl25,341,885 - 5,351,680 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx212,448,925 - 12,458,659 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0210,548,158 - 10,557,892 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.025,184,459 - 5,194,212 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.022,606,032 - 2,615,944 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl22,605,996 - 2,615,944 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.022,604,479 - 2,614,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.422,888,605 - 2,899,216 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.122,908,046 - 2,918,657 (+)NCBI
Celera21,812,028 - 1,821,780 (+)NCBICelera
Cytogenetic Map2q11NCBI
GLRX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38595,813,849 - 95,822,726 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl595,751,319 - 95,822,726 (-)EnsemblGRCh38hg38GRCh38
GRCh37595,149,553 - 95,158,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36595,175,431 - 95,184,137 (-)NCBINCBI36Build 36hg18NCBI36
Build 34595,175,430 - 95,184,137NCBI
Celera591,028,293 - 91,037,329 (-)NCBICelera
Cytogenetic Map5q15NCBI
HuRef590,339,863 - 90,348,899 (-)NCBIHuRef
CHM1_1594,582,332 - 94,591,368 (-)NCBICHM1_1
T2T-CHM13v2.0596,315,076 - 96,323,967 (-)NCBIT2T-CHM13v2.0
Glrx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391375,988,004 - 75,998,270 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1375,987,987 - 75,998,273 (+)EnsemblGRCm39 Ensembl
GRCm381375,839,885 - 75,850,151 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1375,839,868 - 75,850,154 (+)EnsemblGRCm38mm10GRCm38
MGSCv371375,977,334 - 75,987,599 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361376,305,914 - 76,316,151 (+)NCBIMGSCv36mm8
Celera1378,161,342 - 78,171,745 (+)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.95NCBI
Glrx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541816,747,776 - 16,752,858 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541816,747,709 - 16,754,718 (+)NCBIChiLan1.0ChiLan1.0
GLRX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2419,556,150 - 19,565,082 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1517,709,918 - 17,718,694 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0519,526,210 - 19,535,237 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1519,671,833 - 19,680,685 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl519,671,965 - 19,680,685 (+)Ensemblpanpan1.1panPan2
GLRX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1313,795,609 - 13,804,732 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl313,795,817 - 13,803,895 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha315,134,941 - 15,144,033 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0313,675,696 - 13,684,691 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl313,675,662 - 13,684,677 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1313,638,543 - 13,647,633 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0313,635,534 - 13,644,630 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0313,835,410 - 13,844,529 (+)NCBIUU_Cfam_GSD_1.0
Glrx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213169,350,320 - 169,358,900 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365237,535,857 - 7,541,864 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365237,535,650 - 7,544,339 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLRX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2102,425,580 - 102,437,858 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12102,425,580 - 102,437,851 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22106,309,433 - 106,321,705 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GLRX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1489,687,354 - 89,696,236 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl489,685,984 - 89,696,231 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604938,333,100 - 38,342,156 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glrx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474314,442,803 - 14,451,975 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474314,443,394 - 14,451,561 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Glrx
37 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:87
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000016372
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat

Markers in Region
RH127501  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.225,351,229 - 5,351,430 (+)MAPPERmRatBN7.2
Rnor_6.022,615,495 - 2,615,695NCBIRnor6.0
Rnor_5.022,613,942 - 2,614,142UniSTSRnor5.0
RGSC_v3.422,898,767 - 2,898,967UniSTSRGSC3.4
Celera21,821,331 - 1,821,531UniSTS
Cytogenetic Map2q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF167981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF319950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB874331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB874886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB881242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB882389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB890988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB892812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB894110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB895460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB903291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC931740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC932295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC938651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC939798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC948397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC950221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC951519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC952869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC960700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000016372   ⟹   ENSRNOP00000016372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl25,341,885 - 5,351,680 (+)Ensembl
Rnor_6.0 Ensembl22,605,996 - 2,615,944 (+)Ensembl
RefSeq Acc Id: NM_022278   ⟹   NP_071614
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr827,073,795 - 7,083,544 (+)NCBI
mRatBN7.225,341,930 - 5,351,679 (+)NCBI
Rnor_6.022,606,032 - 2,615,944 (+)NCBI
Rnor_5.022,604,479 - 2,614,391 (+)NCBI
RGSC_v3.422,888,605 - 2,899,216 (+)RGD
Celera21,812,028 - 1,821,780 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103033   ⟹   XP_038958961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr827,073,737 - 7,083,548 (+)NCBI
mRatBN7.225,341,873 - 5,351,686 (+)NCBI
RefSeq Acc Id: NP_071614   ⟸   NM_022278
- UniProtKB: Q99PB7 (UniProtKB/Swiss-Prot),   Q9ESH6 (UniProtKB/Swiss-Prot),   A6I4F1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016372   ⟸   ENSRNOT00000016372
RefSeq Acc Id: XP_038958961   ⟸   XM_039103033
- Peptide Label: isoform X1
- UniProtKB: Q9ESH6 (UniProtKB/Swiss-Prot),   Q99PB7 (UniProtKB/Swiss-Prot),   A6I4F1 (UniProtKB/TrEMBL)
Protein Domains
Glutaredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ESH6-F1-model_v2 AlphaFold Q9ESH6 1-107 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691032
Promoter ID:EPDNEW_R1557
Type:multiple initiation site
Name:Glrx_1
Description:glutaredoxin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.022,606,005 - 2,606,065EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70951 AgrOrtholog
BioCyc Gene G2FUF-55090 BioCyc
BioCyc Pathway PWY-6370 [ascorbate recycling (cytosolic)] BioCyc
BioCyc Pathway Image PWY-6370 BioCyc
Ensembl Genes ENSRNOG00000012183 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016372 ENTREZGENE
  ENSRNOT00000016372.6 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6889009 IMAGE-MGC_LOAD
InterPro GLR_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLRX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin_euk/vir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin_subgr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64045 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72841 IMAGE-MGC_LOAD
NCBI Gene 64045 ENTREZGENE
PANTHER GLUTAREDOXIN-1 UniProtKB/Swiss-Prot
  GLUTAREDOXIN-1 UniProtKB/Swiss-Prot
  GLUTAREDOXIN-1 UniProtKB/TrEMBL
  GLUTAREDOXIN-1 UniProtKB/TrEMBL
Pfam Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Glrx PhenoGen
PRINTS GLUTAREDOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUTAREDOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTAREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012183 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6I4F1 ENTREZGENE, UniProtKB/TrEMBL
  GLRX1_RAT UniProtKB/Swiss-Prot
  Q99PB7 ENTREZGENE
  Q9ESH6 ENTREZGENE
UniProt Secondary Q99PB7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Glrx  glutaredoxin  Glrx  glutaredoxin (thioltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-25 Glrx  glutaredoxin (thioltransferase)  Glrx1  glutaredoxin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-06 Glrx1  glutaredoxin 1  Glrx1  glutaredoxin 1 (thioltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Glrx1  glutaredoxin 1 (thioltransferase)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization activity localizes to mitochondria 632899