Sort1 (sortilin 1) - Rat Genome Database

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Gene: Sort1 (sortilin 1) Rattus norvegicus
Analyze
Symbol: Sort1
Name: sortilin 1
RGD ID: 619999
Description: Predicted to enable several functions, including nerve growth factor binding activity; nerve growth factor receptor activity; and neurotensin receptor activity, non-G protein-coupled. Involved in positive regulation of epithelial cell apoptotic process. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm. Orthologous to human SORT1 (sortilin 1); PARTICIPATES IN neurotrophic factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glycoprotein 110; gp110; neurotensin receptor 3; Nt3; NTR3; Nts3; sortilin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,609,466 - 198,690,481 (+)NCBIGRCr8
mRatBN7.22195,924,033 - 196,002,354 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,924,099 - 196,002,354 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,567,532 - 203,645,624 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,449,641 - 201,527,742 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02196,266,598 - 196,344,698 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02211,078,092 - 211,156,312 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2211,078,334 - 211,156,312 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,546,773 - 230,626,278 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,853,009 - 203,931,559 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,816,049 - 203,890,296 (+)NCBI
Celera2188,569,202 - 188,647,900 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
bafilomycin A1  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
cycloheximide  (EXP,ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
etoposide  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
FR900359  (ISO)
furan  (EXP)
hexadecanoic acid  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
mitomycin C  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
PX-866  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
streptozocin  (ISO)
taurocholic acid  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
wortmannin  (ISO)
Yessotoxin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes. Morris NJ, etal., J Biol Chem 1998 Feb 6;273(6):3582-7.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system. Sarret P, etal., J Comp Neurol 2003 Jul 7;461(4):483-505.
10. A DAB2IP genotype: sex interaction is associated with abdominal aortic aneurysm expansion. Ye Z, etal., J Investig Med. 2017 Oct;65(7):1077-1082. doi: 10.1136/jim-2016-000404. Epub 2017 Jul 11.
11. Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis. Zou T, etal., Am J Physiol Cell Physiol. 2012 Jul 1;303(1):C102-11. doi: 10.1152/ajpcell.00009.2012. Epub 2012 May 2.
Additional References at PubMed
PMID:9305862   PMID:9756851   PMID:10085125   PMID:11331584   PMID:12490950   PMID:12771154   PMID:14985763   PMID:15057822   PMID:15078902   PMID:15987945   PMID:15992544   PMID:17997040  
PMID:18090258   PMID:18258592   PMID:18817523   PMID:19429059   PMID:19732768   PMID:20083190   PMID:21092856   PMID:21261755   PMID:21730062   PMID:22715380   PMID:24163244   PMID:24404198  
PMID:24928897   PMID:26629404   PMID:27495870   PMID:27980238   PMID:28541286   PMID:29196163   PMID:34626084   PMID:36859404  


Genomics

Comparative Map Data
Sort1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,609,466 - 198,690,481 (+)NCBIGRCr8
mRatBN7.22195,924,033 - 196,002,354 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,924,099 - 196,002,354 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,567,532 - 203,645,624 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,449,641 - 201,527,742 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02196,266,598 - 196,344,698 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02211,078,092 - 211,156,312 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2211,078,334 - 211,156,312 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,546,773 - 230,626,278 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,853,009 - 203,931,559 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,816,049 - 203,890,296 (+)NCBI
Celera2188,569,202 - 188,647,900 (+)NCBICelera
Cytogenetic Map2q34NCBI
SORT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,309,575 - 109,397,918 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1109,309,568 - 109,397,918 (-)EnsemblGRCh38hg38GRCh38
GRCh371109,852,197 - 109,940,540 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361109,653,715 - 109,742,086 (-)NCBINCBI36Build 36hg18NCBI36
Build 341109,564,233 - 109,652,605NCBI
Celera1108,121,561 - 108,209,921 (-)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1107,745,442 - 107,833,803 (-)NCBIHuRef
CHM1_11109,967,032 - 110,055,400 (-)NCBICHM1_1
T2T-CHM13v2.01109,342,381 - 109,430,699 (-)NCBIT2T-CHM13v2.0
Sort1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393108,191,272 - 108,268,835 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3108,191,398 - 108,268,827 (+)EnsemblGRCm39 Ensembl
GRCm383108,283,974 - 108,361,519 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3108,284,082 - 108,361,511 (+)EnsemblGRCm38mm10GRCm38
MGSCv373108,087,050 - 108,164,429 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363108,412,188 - 108,489,567 (+)NCBIMGSCv36mm8
Celera3110,641,971 - 110,695,148 (+)NCBICelera
Cytogenetic Map3F3NCBI
cM Map346.9NCBI
Sort1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543512,730,270 - 12,819,029 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543512,725,952 - 12,819,280 (-)NCBIChiLan1.0ChiLan1.0
SORT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21117,906,698 - 117,994,934 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11117,066,633 - 117,154,840 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01111,687,119 - 111,775,339 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11110,850,311 - 110,888,690 (-)NCBIpanpan1.1PanPan1.1panPan2
SORT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1642,454,091 - 42,521,251 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl642,453,942 - 42,516,740 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha645,228,326 - 45,295,415 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0642,784,113 - 42,848,096 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl642,783,933 - 42,851,871 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1642,517,324 - 42,583,603 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0642,474,716 - 42,541,652 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0642,909,755 - 42,976,918 (+)NCBIUU_Cfam_GSD_1.0
Sort1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505819,210,972 - 19,281,426 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936704837,057 - 901,392 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936704832,651 - 901,658 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SORT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4110,720,947 - 110,789,070 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14110,721,110 - 110,791,406 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24121,230,024 - 121,289,561 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SORT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12024,150,210 - 24,235,518 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2024,150,300 - 24,239,503 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603834,220,514 - 34,309,885 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sort1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247725,049,045 - 5,123,365 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247725,044,948 - 5,123,300 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sort1
559 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:133
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000049127
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat

Markers in Region
D2Rat51  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,931,945 - 195,932,102 (+)MAPPERmRatBN7.2
Rnor_6.02211,085,920 - 211,086,076NCBIRnor6.0
Rnor_5.02230,555,257 - 230,555,413UniSTSRnor5.0
RGSC_v3.42203,860,594 - 203,860,751RGDRGSC3.4
RGSC_v3.42203,860,595 - 203,860,751UniSTSRGSC3.4
RGSC_v3.12203,823,349 - 203,823,505RGD
Celera2188,576,788 - 188,576,944UniSTS
RH 3.4 Map21395.3UniSTS
RH 3.4 Map21395.3RGD
SHRSP x BN Map274.0098UniSTS
SHRSP x BN Map274.0098RGD
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 22 6 19 6 8 11 74 35 41 11 8
Low 1 35 35 35
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000049127   ⟹   ENSRNOP00000051102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,924,362 - 196,002,354 (+)Ensembl
Rnor_6.0 Ensembl2211,078,334 - 211,156,312 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108279   ⟹   ENSRNOP00000082085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,924,099 - 196,002,354 (+)Ensembl
RefSeq Acc Id: NM_031767   ⟹   NP_113955
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,612,495 - 198,690,481 (+)NCBI
mRatBN7.22195,924,362 - 196,002,354 (+)NCBI
Rnor_6.02211,078,334 - 211,156,312 (+)NCBI
Rnor_5.02230,546,773 - 230,626,278 (+)NCBI
RGSC_v3.42203,853,009 - 203,931,559 (+)RGD
Celera2188,569,202 - 188,647,900 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233194   ⟹   XP_006233256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,609,466 - 198,690,408 (+)NCBI
mRatBN7.22195,924,034 - 196,002,354 (+)NCBI
Rnor_6.02211,078,092 - 211,156,308 (+)NCBI
Rnor_5.02230,546,773 - 230,626,278 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233195   ⟹   XP_006233257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,609,466 - 198,690,408 (+)NCBI
mRatBN7.22195,924,033 - 196,002,354 (+)NCBI
Rnor_6.02211,078,092 - 211,156,308 (+)NCBI
Rnor_5.02230,546,773 - 230,626,278 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233196   ⟹   XP_006233258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,609,466 - 198,690,408 (+)NCBI
mRatBN7.22195,924,036 - 196,002,354 (+)NCBI
Rnor_6.02211,078,279 - 211,156,312 (+)NCBI
Rnor_5.02230,546,773 - 230,626,278 (+)NCBI
Sequence:
RefSeq Acc Id: NP_113955   ⟸   NM_031767
- Peptide Label: precursor
- UniProtKB: O35389 (UniProtKB/Swiss-Prot),   O54861 (UniProtKB/Swiss-Prot),   A0A8L2QPF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233257   ⟸   XM_006233195
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G6Z1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233256   ⟸   XM_006233194
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G6Z1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233258   ⟸   XM_006233196
- Peptide Label: isoform X3
- UniProtKB: A0A8I6G6Z1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051102   ⟸   ENSRNOT00000049127
RefSeq Acc Id: ENSRNOP00000082085   ⟸   ENSRNOT00000108279
Protein Domains
Sortilin N-terminal   VPS10

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54861-F1-model_v2 AlphaFold O54861 1-825 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691678
Promoter ID:EPDNEW_R2203
Type:initiation region
Name:Sort1_1
Description:sortilin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02211,078,331 - 211,078,391EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619999 AgrOrtholog
BioCyc Gene G2FUF-51622 BioCyc
Ensembl Genes ENSRNOG00000031814 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049127.6 UniProtKB/TrEMBL
  ENSRNOT00000108279 ENTREZGENE
  ENSRNOT00000108279.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.70.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.270 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Sortilin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sortilin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VPS10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83576 UniProtKB/Swiss-Prot
NCBI Gene 83576 ENTREZGENE
PANTHER SORTILIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SORTILIN RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sortilin-Vps10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sortilin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sort1 PhenoGen
RatGTEx ENSRNOG00000031814 RatGTEx
SMART VPS10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Oligoxyloglucan reducing end-specific cellobiohydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6G6Z1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QPF6 ENTREZGENE, UniProtKB/TrEMBL
  A6HUZ4_RAT UniProtKB/TrEMBL
  A6HUZ5_RAT UniProtKB/TrEMBL
  O35389 ENTREZGENE
  O54861 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O35389 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Sort1  sortilin 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Sort1  sortilin 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to vesicles and plasma membrane 730041
gene_cellular_localization predominantly localized to the membrane of intracellular membrane-bound organelles 1299257