Predicted to enable several functions, including nerve growth factor binding activity; nerve growth factor receptor activity; and neurotensin receptor activity, non-G protein-coupled. Involved in positive regulation of epithelial cell apoptotic process. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm. Orthologous to human SORT1 (sortilin 1); PARTICIPATES IN neurotrophic factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SORT1 mRNA
[[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of SORT1 mRNA
Chloroquine affects the reaction [SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]] and SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]
Cycloheximide promotes the reaction [Palmitic Acid results in increased degradation of SORT1 protein] and Docosahexaenoic Acids inhibits the reaction [Cycloheximide promotes the reaction [Palmitic Acid results in increased degradation of SORT1 protein]]
SORT1 mutant form inhibits the reaction [Pentanoic Acids results in decreased susceptibility to [TNF protein co-treated with Cycloheximide]] and SORT1 mutant form inhibits the reaction [sodium arsenite results in decreased susceptibility to [TNF protein co-treated with Cycloheximide]]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SORT1 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SORT1 mRNA
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tetrabromocinnamic acid results in increased degradation of SORT1 protein] and benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [wortmannin results in increased degradation of SORT1 protein]
