SORT1 (sortilin 1) - Rat Genome Database

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Gene: SORT1 (sortilin 1) Sus scrofa
Analyze
Symbol: SORT1
Name: sortilin 1
RGD ID: 14104754
Description: ENCODES a protein that exhibits enzyme binding (inferred); nerve growth factor binding (inferred); nerve growth factor receptor activity (inferred); INVOLVED IN endocytosis (ortholog); G protein-coupled receptor signaling pathway (ortholog); negative regulation of fat cell differentiation (ortholog); ASSOCIATED WITH autistic disorder (ortholog); cardiovascular system disease (ortholog); cholestasis (ortholog); FOUND IN clathrin-coated vesicle (ortholog); cytoplasmic vesicle (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: sortilin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4110,720,100 - 110,789,702 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14110,721,110 - 110,791,406 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24121,230,024 - 121,289,561 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
SORT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4110,720,100 - 110,789,702 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14110,721,110 - 110,791,406 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24121,230,024 - 121,289,561 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SORT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1109,309,568 - 109,397,918 (-)EnsemblGRCh38hg38GRCh38
GRCh381109,309,575 - 109,397,940 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371109,852,197 - 109,940,540 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361109,653,715 - 109,742,086 (-)NCBINCBI36hg18NCBI36
Build 341109,564,233 - 109,652,605NCBI
Celera1108,121,561 - 108,209,921 (-)NCBI
Cytogenetic Map1p13.3NCBI
HuRef1107,745,442 - 107,833,803 (-)NCBIHuRef
CHM1_11109,967,032 - 110,055,404 (-)NCBICHM1_1
Sort1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393108,191,272 - 108,268,835 (+)NCBIGRCm39mm39
GRCm39 Ensembl3108,191,398 - 108,268,827 (+)Ensembl
GRCm383108,283,974 - 108,361,519 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3108,284,082 - 108,361,511 (+)EnsemblGRCm38mm10GRCm38
MGSCv373108,087,050 - 108,164,429 (+)NCBIGRCm37mm9NCBIm37
MGSCv363108,412,188 - 108,489,567 (+)NCBImm8
Celera3110,641,971 - 110,695,148 (+)NCBICelera
Cytogenetic Map3F3NCBI
Sort1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22195,924,033 - 196,002,354 (+)NCBI
Rnor_6.0 Ensembl2211,078,334 - 211,156,312 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02211,078,092 - 211,156,312 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02230,546,773 - 230,626,278 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,853,009 - 203,931,559 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12203,816,049 - 203,890,296 (+)NCBI
Celera2188,569,202 - 188,647,900 (+)NCBICelera
Cytogenetic Map2q34NCBI
Sort1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543512,730,270 - 12,819,029 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543512,725,952 - 12,819,280 (-)NCBIChiLan1.0ChiLan1.0
SORT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11110,850,311 - 110,888,690 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01111,687,119 - 111,775,339 (-)NCBIMhudiblu_PPA_v0panPan3
SORT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1642,454,091 - 42,521,251 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl642,453,942 - 42,516,740 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha645,228,326 - 45,295,415 (+)NCBI
ROS_Cfam_1.0642,784,113 - 42,848,096 (+)NCBI
UMICH_Zoey_3.1642,517,324 - 42,583,603 (+)NCBI
UNSW_CanFamBas_1.0642,474,716 - 42,541,652 (+)NCBI
UU_Cfam_GSD_1.0642,909,755 - 42,976,918 (+)NCBI
Sort1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505819,210,972 - 19,281,426 (+)NCBI
SpeTri2.0NW_004936704832,651 - 901,658 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SORT1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12024,150,210 - 24,235,518 (+)NCBI
ChlSab1.1 Ensembl2024,150,300 - 24,239,503 (+)Ensembl
Sort1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247725,044,948 - 5,123,300 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 1 21 2 2 2
Low 2 4 2 5 2 2 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013997288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK235323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK236900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK240123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK389500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK397320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK397624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK397870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU207229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01051277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE650897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE650898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE650899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE650900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE650901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE650902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE650903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HE650904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000007482   ⟹   ENSSSCP00000007286
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4110,720,100 - 110,789,702 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000063798   ⟹   ENSSSCP00000034340
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4110,720,100 - 110,789,092 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000065281   ⟹   ENSSSCP00000037889
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4110,720,100 - 110,789,702 (+)Ensembl
RefSeq Acc Id: XM_013997288   ⟹   XP_013852742
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14110,721,110 - 110,791,406 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090071   ⟹   XP_020945730
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14110,721,145 - 110,791,406 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090072   ⟹   XP_020945731
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14110,721,169 - 110,791,406 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021090073   ⟹   XP_020945732
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14110,721,170 - 110,791,406 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013852742   ⟸   XM_013997288
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020945730   ⟸   XM_021090071
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020945731   ⟸   XM_021090072
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020945732   ⟸   XM_021090073
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSSSCP00000037889   ⟸   ENSSSCT00000065281
RefSeq Acc Id: ENSSSCP00000007286   ⟸   ENSSSCT00000007482
RefSeq Acc Id: ENSSSCP00000034340   ⟸   ENSSSCT00000063798
Protein Domains
Sortilin-Vps10   VPS10


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006831 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000007286 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000034340 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000037889 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000007482 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000063798 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000065281 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro BNR_rpt UniProtKB/TrEMBL
  Sortilin_C UniProtKB/TrEMBL
  Sortilin_N UniProtKB/TrEMBL
  VPS10 UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:106504120 UniProtKB/TrEMBL
NCBI Gene SORT1 ENTREZGENE
Pfam BNR_6 UniProtKB/TrEMBL
  Sortilin-Vps10 UniProtKB/TrEMBL
  Sortilin_C UniProtKB/TrEMBL
SMART VPS10 UniProtKB/TrEMBL
UniProt A0A286ZSA0_PIG UniProtKB/TrEMBL
  A0A287A1U0_PIG UniProtKB/TrEMBL
  A0A480IRZ7_PIG UniProtKB/TrEMBL
  F1S5Z7_PIG UniProtKB/TrEMBL
  H2B2M0_PIG UniProtKB/TrEMBL
  H2B2M1_PIG UniProtKB/TrEMBL
VGNC ID VGNC:93343 ENTREZGENE