Gene: Pfkfb2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2) Rattus norvegicus
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Symbol: Pfkfb2
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Description: ENCODES a protein that exhibits fructose-2,6-bisphosphate 2-phosphatase activity; kinase binding; 6-phosphofructo-2-kinase activity (ortholog); INVOLVED IN glucose catabolic process; lactate metabolic process; positive regulation of glucokinase activity; PARTICIPATES IN fructose and mannose metabolic pathway; glycolysis pathway; ASSOCIATED WITH autistic disorder (ortholog); FOUND IN cytoplasm; nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2-ethoxyethanol; 2-methoxyethanol; ammonium chloride
AGR Description: Exhibits fructose-2,6-bisphosphate 2-phosphatase activity and kinase binding activity; involved in several processes, including glucose catabolic process, monocarboxylic acid metabolic process, and positive regulation of glucokinase activity; localizes to the cytoplasm; orthologous to human PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2).
Merged Description: Exhibits fructose-2,6-bisphosphate 2-phosphatase activity and kinase binding activity; involved in several processes, including glucose catabolic process, monocarboxylic acid metabolic process, and positive regulation of glucokinase activity; localizes to the cytoplasm; orthologous to human PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); PARTICIPATES IN fructose and mannose metabolic pathway; glycolysis pathway; INTERACTS WITH 2-ethoxyethanol; 2-methoxyethanol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (heart); 6-phosphofructo-2-kinase/fructose-26-bisphosphatase 2 (heart); 6-phosphofructo-2-kinase/fructose-26-bisphosphatase 2 (heart) (conflicting physical mapping); 6PF-2-K/Fru-2,6-P2ase 2; 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme; fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase; PFK-2; PFK-2/FBPase-2; PFK/FBPase 2; RH2K
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01347,413,453 - 47,440,682 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01352,502,121 - 52,529,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,624,838 - 43,652,660 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11343,641,369 - 43,666,703 (-)NCBI
Celera1342,498,231 - 42,525,453 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pfkfb2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3309
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.