Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Pfkfb2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PFKFB2 mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | affects expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine affects the expression of PFKFB2 mRNA | CTD | PMID:22206623 | 17beta-estradiol | affects expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | Estradiol affects the expression of PFKFB2 mRNA | CTD | PMID:22574217 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of PFKFB2 mRNA | CTD | PMID:29581250 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Pfkfb2 (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of PFKFB2 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PFKFB2 promoter] | CTD | PMID:19654925 and PMID:25975270 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PFKFB2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PFKFB2 mRNA | CTD | PMID:21889950 | 2-ethoxyethanol | increases expression | EXP | | 6480464 | 2-ethoxyethanol results in increased expression of PFKFB2 mRNA | CTD | PMID:19643169 | 2-methoxyethanol | increases expression | EXP | | 6480464 | methyl cellosolve results in increased expression of PFKFB2 mRNA | CTD | PMID:19643169 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PFKFB2 mRNA | CTD | PMID:20188158 | 3,4-methylenedioxymethamphetamine | increases methylation | ISO | Pfkfb2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of PFKFB2 promoter | CTD | PMID:26251327 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PFKFB2 mRNA | CTD | PMID:26251327 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of PFKFB2 protein | CTD | PMID:34915118 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Pfkfb2 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of PFKFB2 exon | CTD | PMID:33297965 | 4-hydroxyphenyl retinamide | increases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | Fenretinide results in increased expression of PFKFB2 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of PFKFB2 mRNA | CTD | PMID:30047161 | aflatoxin B1 | increases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of PFKFB2 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | PFKFB2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of PFKFB2 gene | CTD | PMID:27153756 | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of PFKFB2 mRNA | CTD | PMID:30047161 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PFKFB2 mRNA | CTD | PMID:16483693 | arsenite(3-) | multiple interactions | ISO | PFKFB2 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PFKFB2 mRNA] | CTD | PMID:32406909 | aspartame | multiple interactions | ISO | Pfkfb2 (Mus musculus) | 6480464 | [Fats more ... | CTD | PMID:23783067 | benzo[a]pyrene | multiple interactions | ISO | Pfkfb2 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PFKFB2 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | decreases methylation | ISO | PFKFB2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PFKFB2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | PFKFB2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PFKFB2 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | increases expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | bis(2-chloroethyl) sulfide | increases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | Mustard Gas results in increased expression of PFKFB2 mRNA | CTD | PMID:15674844 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PFKFB2 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PFKFB2 mRNA | CTD | PMID:32156529 | bisphenol A | multiple interactions | ISO | PFKFB2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of PFKFB2 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PFKFB2 mRNA | CTD | PMID:30816183 more ... | bisphenol A | increases expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PFKFB2 mRNA | CTD | PMID:29275510 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of PFKFB2 mRNA | CTD | PMID:33453195 | caffeine | decreases phosphorylation | ISO | PFKFB2 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of PFKFB2 protein | CTD | PMID:35688186 | calcitriol | increases expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of PFKFB2 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | PFKFB2 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of PFKFB2 mRNA | CTD | PMID:21592394 | carbon nanotube | decreases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of PFKFB2 mRNA | CTD | PMID:25554681 | carbon nanotube | increases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of PFKFB2 mRNA | CTD | PMID:25620056 | carmustine | decreases expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | Carmustine results in decreased expression of PFKFB2 mRNA | CTD | PMID:15980968 | choline | multiple interactions | ISO | Pfkfb2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PFKFB2 more ... | CTD | PMID:20938992 | ciguatoxin CTX1B | affects expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of PFKFB2 mRNA | CTD | PMID:18353800 | cisplatin | multiple interactions | ISO | PFKFB2 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of PFKFB2 mRNA | CTD | PMID:27392435 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of PFKFB2 mRNA | CTD | PMID:22465980 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of PFKFB2 mRNA | CTD | PMID:22465980 | coumarin | increases phosphorylation | ISO | PFKFB2 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of PFKFB2 protein | CTD | PMID:35688186 | decabromodiphenyl ether | increases expression | EXP | | 6480464 | decabromobiphenyl ether results in increased expression of PFKFB2 mRNA | CTD | PMID:23914054 | dorsomorphin | multiple interactions | ISO | PFKFB2 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PFKFB2 mRNA | CTD | PMID:27188386 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of PFKFB2 mRNA | CTD | PMID:30307764 | folic acid | multiple interactions | ISO | Pfkfb2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PFKFB2 more ... | CTD | PMID:20938992 | folic acid | decreases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of PFKFB2 mRNA | CTD | PMID:25629700 | formaldehyde | increases expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of PFKFB2 mRNA | CTD | PMID:27664576 | FR900359 | affects phosphorylation | ISO | PFKFB2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of PFKFB2 protein | CTD | PMID:37730182 | FR900359 | decreases expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | FR900359 results in decreased expression of PFKFB2 protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | PFKFB2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of PFKFB2 gene | CTD | PMID:31601247 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of PFKFB2 mRNA | CTD | PMID:25539665 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PFKFB2 mRNA | CTD | PMID:33387578 | glyphosate | affects methylation | EXP | | 6480464 | Glyphosate affects the methylation of PFKFB2 gene | CTD | PMID:35440735 | hydrazine | decreases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | hydrazine results in decreased expression of PFKFB2 mRNA | CTD | PMID:15282401 | L-methionine | multiple interactions | ISO | Pfkfb2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PFKFB2 more ... | CTD | PMID:20938992 | lead(0) | affects expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | Lead affects the expression of PFKFB2 mRNA | CTD | PMID:28903495 | lithium carbonate | decreases activity | EXP | | 6480464 | Lithium Carbonate results in decreased activity of PFKFB2 protein | CTD | PMID:10700396 | lithium carbonate | multiple interactions | EXP | | 6480464 | Lithium Carbonate inhibits the reaction [Streptozocin results in decreased activity of PFKFB2 protein] | CTD | PMID:10700396 | methamphetamine | decreases methylation | ISO | Pfkfb2 (Mus musculus) | 6480464 | Methamphetamine results in decreased methylation of PFKFB2 promoter | CTD | PMID:26307267 | methamphetamine | increases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | Methamphetamine results in increased expression of PFKFB2 mRNA | CTD | PMID:26307267 | monosodium L-glutamate | multiple interactions | ISO | Pfkfb2 (Mus musculus) | 6480464 | [Fats more ... | CTD | PMID:23783067 | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of PFKFB2 mRNA | CTD | PMID:28801915 | p-chloromercuribenzoic acid | multiple interactions | ISO | PFKFB2 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PFKFB2 mRNA | CTD | PMID:27188386 | paracetamol | affects expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of PFKFB2 mRNA | CTD | PMID:17562736 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Pfkfb2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PFKFB2 mRNA | CTD | PMID:36331819 | pirinixic acid | multiple interactions | ISO | Pfkfb2 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PFKFB2 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of PFKFB2 mRNA | CTD | PMID:19162173 | pirinixic acid | increases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of PFKFB2 mRNA | CTD | PMID:18445702 | pirinixic acid | decreases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of PFKFB2 mRNA | CTD | PMID:20813756 | resveratrol | multiple interactions | ISO | PFKFB2 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of PFKFB2 mRNA | CTD | PMID:23557933 | SB 431542 | multiple interactions | ISO | PFKFB2 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PFKFB2 mRNA | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of PFKFB2 mRNA | CTD | PMID:25895662 | streptozocin | multiple interactions | EXP | | 6480464 | Lithium Carbonate inhibits the reaction [Streptozocin results in decreased activity of PFKFB2 protein] | CTD | PMID:10700396 | streptozocin | decreases activity | EXP | | 6480464 | Streptozocin results in decreased activity of PFKFB2 protein | CTD | PMID:10700396 | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of PFKFB2 mRNA | CTD | PMID:30047161 | sunitinib | increases expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PFKFB2 mRNA | CTD | PMID:31533062 | testosterone | multiple interactions | ISO | PFKFB2 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of PFKFB2 mRNA | CTD | PMID:21592394 | testosterone | increases expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | Testosterone results in increased expression of PFKFB2 mRNA | CTD | PMID:21592394 | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of PFKFB2 mRNA | CTD | PMID:12734012 | tetraphene | increases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | benz(a)anthracene results in increased expression of PFKFB2 mRNA | CTD | PMID:26377693 | thapsigargin | decreases expression | EXP | | 6480464 | Thapsigargin results in decreased expression of PFKFB2 protein | CTD | PMID:35544339 | thimerosal | decreases expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of PFKFB2 mRNA | CTD | PMID:27188386 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of PFKFB2 mRNA | CTD | PMID:34492290 | titanium dioxide | affects expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | titanium dioxide affects the expression of PFKFB2 mRNA | CTD | PMID:17656681 | titanium dioxide | decreases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of PFKFB2 mRNA | CTD | PMID:29264374 | triptonide | increases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | triptonide results in increased expression of PFKFB2 mRNA | CTD | PMID:33045310 | valproic acid | increases expression | ISO | Pfkfb2 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of PFKFB2 mRNA | CTD | PMID:19136453 and PMID:21427059 | valproic acid | affects expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PFKFB2 mRNA | CTD | PMID:25979313 | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of PFKFB2 gene | CTD | PMID:31682807 | zearalenone | decreases expression | ISO | PFKFB2 (Homo sapiens) | 6480464 | Zearalenone results in decreased expression of PFKFB2 mRNA | CTD | PMID:19371625 | zinc atom | decreases expression | EXP | | 6480464 | Zinc results in decreased expression of PFKFB2 mRNA | CTD | PMID:17074742 | zinc sulfate | decreases expression | EXP | | 6480464 | Zinc Sulfate results in decreased expression of PFKFB2 mRNA | CTD | PMID:17074742 | zinc(0) | decreases expression | EXP | | 6480464 | Zinc results in decreased expression of PFKFB2 mRNA | CTD | PMID:17074742 | |