Pfkfb2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2) - Rat Genome Database

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Gene: Pfkfb2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2) Rattus norvegicus
Analyze
Symbol: Pfkfb2
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
RGD ID: 3309
Description: Enables fructose-2,6-bisphosphate 2-phosphatase activity and kinase binding activity. Involved in several processes, including monocarboxylic acid metabolic process; positive regulation of insulin secretion; and response to glucose. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Orthologous to human PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); PARTICIPATES IN fructose and mannose metabolic pathway; glycolysis pathway; INTERACTS WITH 2-ethoxyethanol; 2-methoxyethanol; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (heart); 6-phosphofructo-2-kinase/fructose-26-bisphosphatase 2 (heart); 6-phosphofructo-2-kinase/fructose-26-bisphosphatase 2 (heart) (conflicting physical mapping); 6PF-2-K/Fru-2,6-P2ase 2; 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme; fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase; PFK-2; PFK-2/FBPase-2; PFK/FBPase 2; RH2K
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81344,683,499 - 44,727,135 (-)NCBIGRCr8
mRatBN7.21342,147,473 - 42,174,699 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,147,478 - 42,174,699 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1344,754,082 - 44,781,270 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,042,224 - 46,069,414 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,286,917 - 43,314,104 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,413,453 - 47,440,682 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,413,458 - 47,440,682 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,502,121 - 52,529,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,624,838 - 43,652,660 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11343,641,369 - 43,666,703 (-)NCBI
Celera1342,498,231 - 42,525,453 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumarin  (ISO)
decabromodiphenyl ether  (EXP)
dorsomorphin  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
hydrazine  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lithium carbonate  (EXP)
methamphetamine  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP,ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IEA)
nucleoplasm  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells. Arden C, etal., Biochem J. 2008 Apr 1;411(1):41-51.
2. Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells. Baltrusch S, etal., Endocrinology. 2006 Dec;147(12):5768-76. Epub 2006 Sep 15.
3. Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner. Baltrusch S, etal., J Biol Chem. 2001 Nov 23;276(47):43915-23. Epub 2001 Aug 24.
4. Molecular cloning and tissue-specific expression of mouse kidney 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Batra RS, etal., FEBS Lett 1996 Sep 16;393(2-3):167-73.
5. A rat gene encoding heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Darville MI, etal., FEBS Lett 1991 Aug 19;288(1-2):91-4.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. Rider MH, etal., Biochem J. 2004 Aug 1;381(Pt 3):561-79.
14. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
15. Alternative splicing of novel exons of rat heart-type fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase gene. Watanabe F and Furuya E, Biochem Biophys Res Commun 2001 Apr 6;282(3):803-10.
16. Molecular cloning and tissue specific expression of fructose 6-phosphate,2-kinase:fructose 2,6-bisphosphatase of rat brain. Watanabe F, etal., Biochem Biophys Res Commun 1994 Jan 14;198(1):335-40.
Additional References at PubMed
PMID:1299004   PMID:2837207   PMID:7612629   PMID:8889548   PMID:9464277   PMID:10095107   PMID:11069105   PMID:14623077   PMID:15896703   PMID:17553851   PMID:18199594   PMID:18710022  
PMID:19140452   PMID:23457334  


Genomics

Comparative Map Data
Pfkfb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81344,683,499 - 44,727,135 (-)NCBIGRCr8
mRatBN7.21342,147,473 - 42,174,699 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,147,478 - 42,174,699 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1344,754,082 - 44,781,270 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,042,224 - 46,069,414 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,286,917 - 43,314,104 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,413,453 - 47,440,682 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,413,458 - 47,440,682 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,502,121 - 52,529,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,624,838 - 43,652,660 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11343,641,369 - 43,666,703 (-)NCBI
Celera1342,498,231 - 42,525,453 (-)NCBICelera
Cytogenetic Map13q13NCBI
PFKFB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381207,034,416 - 207,081,027 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1207,034,366 - 207,081,024 (+)EnsemblGRCh38hg38GRCh38
GRCh371207,226,620 - 207,254,372 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,293,243 - 205,320,991 (+)NCBINCBI36Build 36hg18NCBI36
Build 341203,615,037 - 203,634,707NCBI
Celera1180,478,124 - 180,505,909 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,923,976 - 177,951,760 (+)NCBIHuRef
CHM1_11208,499,231 - 208,527,022 (+)NCBICHM1_1
T2T-CHM13v2.01206,299,607 - 206,346,250 (+)NCBIT2T-CHM13v2.0
Pfkfb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,616,780 - 130,656,990 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,597,946 - 130,643,536 (-)EnsemblGRCm39 Ensembl
GRCm39 Ensembl1130,616,919 - 130,656,990 (-)EnsemblGRCm39 Ensembl
GRCm381130,689,043 - 130,729,253 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,670,209 - 130,715,799 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,689,182 - 130,729,253 (-)EnsemblGRCm38mm10GRCm38
MGSCv371132,585,620 - 132,625,830 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,516,728 - 132,543,360 (-)NCBIMGSCv36mm8
Celera1133,312,034 - 133,352,649 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.89NCBI
Pfkfb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540642,574,450 - 42,598,109 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540642,573,210 - 42,601,994 (+)NCBIChiLan1.0ChiLan1.0
PFKFB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,293,986 - 42,322,643 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,259,991 - 42,287,893 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01182,655,487 - 182,683,881 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,934,229 - 186,962,001 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,934,446 - 186,961,995 (+)Ensemblpanpan1.1panPan2
PFKFB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.176,193,519 - 6,220,034 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl76,196,656 - 6,218,397 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha75,756,664 - 5,783,300 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.075,882,130 - 5,908,755 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl75,884,641 - 5,908,751 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.175,815,825 - 5,842,428 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,917,370 - 5,943,986 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.075,960,072 - 5,984,198 (+)NCBIUU_Cfam_GSD_1.0
Pfkfb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,319,391 - 68,344,685 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365575,560,746 - 5,585,192 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365575,559,993 - 5,584,912 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PFKFB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl967,681,953 - 67,709,516 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1967,681,786 - 67,716,921 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2974,061,189 - 74,080,759 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PFKFB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,277,692 - 22,306,057 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,286,305 - 22,305,490 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605522,919,723 - 22,948,072 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pfkfb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,420,047 - 4,443,370 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248074,420,577 - 4,442,842 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pfkfb2
189 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:346
Count of miRNA genes:156
Interacting mature miRNAs:184
Transcripts:ENSRNOT00000005729, ENSRNOT00000037679, ENSRNOT00000050354, ENSRNOT00000050859, ENSRNOT00000067445
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat

Markers in Region
D13Mgh12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,155,534 - 42,155,659 (+)MAPPERmRatBN7.2
Rnor_6.01347,421,515 - 47,421,639NCBIRnor6.0
Rnor_5.01352,510,179 - 52,510,303UniSTSRnor5.0
RGSC_v3.41343,633,492 - 43,633,617RGDRGSC3.4
RGSC_v3.41343,633,493 - 43,633,617UniSTSRGSC3.4
RGSC_v3.11343,647,535 - 43,647,660RGD
Celera1342,506,292 - 42,506,410UniSTS
RH 3.4 Map13110.5UniSTS
RH 3.4 Map13110.5RGD
RH 2.0 Map13322.5RGD
Cytogenetic Map13q24-q25UniSTS
RH144599  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,173,824 - 42,173,999 (+)MAPPERmRatBN7.2
Rnor_6.01347,439,808 - 47,439,982NCBIRnor6.0
Rnor_5.01352,528,472 - 52,528,646UniSTSRnor5.0
RGSC_v3.41343,651,786 - 43,651,960UniSTSRGSC3.4
Celera1342,524,579 - 42,524,753UniSTS
RH 3.4 Map13111.2UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map13q24-q25UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 15 14 8 14 8 68 27 35 11
Low 1 28 43 33 5 33 8 11 6 8 6 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001033965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_080477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB040530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB040531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB040532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB040533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB041950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE113134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY312091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ422137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ422138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ438758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ438759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L27084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X61956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000005729   ⟹   ENSRNOP00000005729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,147,478 - 42,174,699 (-)Ensembl
Rnor_6.0 Ensembl1347,415,351 - 47,440,682 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000037679   ⟹   ENSRNOP00000030819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,147,478 - 42,174,699 (-)Ensembl
Rnor_6.0 Ensembl1347,413,458 - 47,440,682 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000050354   ⟹   ENSRNOP00000044506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,156,708 - 42,174,699 (-)Ensembl
Rnor_6.0 Ensembl1347,415,351 - 47,440,682 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000050859   ⟹   ENSRNOP00000044027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,149,371 - 42,174,699 (-)Ensembl
Rnor_6.0 Ensembl1347,421,129 - 47,440,682 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000067445   ⟹   ENSRNOP00000060044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,155,716 - 42,172,378 (-)Ensembl
Rnor_6.0 Ensembl1347,421,696 - 47,438,360 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101692   ⟹   ENSRNOP00000093709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,147,478 - 42,166,379 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117528   ⟹   ENSRNOP00000082431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,147,478 - 42,174,699 (-)Ensembl
RefSeq Acc Id: NM_001033964   ⟹   NP_001029136
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,699,744 - 44,726,971 (-)NCBI
mRatBN7.21342,147,478 - 42,174,699 (-)NCBI
Rnor_6.01347,413,458 - 47,440,682 (-)NCBI
Rnor_5.01352,502,121 - 52,529,346 (-)NCBI
RGSC_v3.41343,624,838 - 43,652,660 (-)RGD
Celera1342,498,231 - 42,525,453 (-)RGD
Sequence:
RefSeq Acc Id: NM_001033965   ⟹   NP_001029137
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,699,744 - 44,726,971 (-)NCBI
mRatBN7.21342,147,478 - 42,174,699 (-)NCBI
Rnor_6.01347,413,458 - 47,440,682 (-)NCBI
Rnor_5.01352,502,121 - 52,529,346 (-)NCBI
RGSC_v3.41343,624,838 - 43,652,660 (-)RGD
Celera1342,498,231 - 42,525,453 (-)RGD
Sequence:
RefSeq Acc Id: NM_080477   ⟹   NP_536725
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,699,744 - 44,726,971 (-)NCBI
mRatBN7.21342,147,478 - 42,174,699 (-)NCBI
Rnor_6.01347,413,458 - 47,440,682 (-)NCBI
Rnor_5.01352,502,121 - 52,529,346 (-)NCBI
RGSC_v3.41343,624,838 - 43,652,660 (-)RGD
Celera1342,498,231 - 42,525,453 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249706   ⟹   XP_006249768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,702,870 - 44,725,869 (-)NCBI
mRatBN7.21342,150,604 - 42,173,610 (-)NCBI
Rnor_6.01347,416,584 - 47,439,557 (-)NCBI
Rnor_5.01352,502,121 - 52,529,346 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249707   ⟹   XP_006249769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,702,870 - 44,725,915 (-)NCBI
mRatBN7.21342,150,604 - 42,173,761 (-)NCBI
Rnor_6.01347,416,584 - 47,439,693 (-)NCBI
Rnor_5.01352,502,121 - 52,529,346 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249708   ⟹   XP_006249770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,702,870 - 44,726,941 (-)NCBI
mRatBN7.21342,150,604 - 42,174,699 (-)NCBI
Rnor_6.01347,416,584 - 47,440,682 (-)NCBI
Rnor_5.01352,502,121 - 52,529,346 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249709   ⟹   XP_006249771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,699,743 - 44,725,869 (-)NCBI
mRatBN7.21342,147,473 - 42,173,610 (-)NCBI
Rnor_6.01347,413,453 - 47,439,557 (-)NCBI
Rnor_5.01352,502,121 - 52,529,346 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249710   ⟹   XP_006249772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,702,870 - 44,718,388 (-)NCBI
mRatBN7.21342,150,604 - 42,172,378 (-)NCBI
Rnor_6.01347,416,584 - 47,438,360 (-)NCBI
Rnor_5.01352,502,121 - 52,529,346 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769425   ⟹   XP_008767647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,702,870 - 44,725,821 (-)NCBI
mRatBN7.21342,150,604 - 42,172,379 (-)NCBI
Rnor_6.01347,416,584 - 47,438,321 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090337   ⟹   XP_038946265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,702,870 - 44,726,029 (-)NCBI
mRatBN7.21342,150,604 - 42,174,666 (-)NCBI
RefSeq Acc Id: XM_039090338   ⟹   XP_038946266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,699,743 - 44,726,029 (-)NCBI
mRatBN7.21342,147,473 - 42,173,785 (-)NCBI
RefSeq Acc Id: XM_039090340   ⟹   XP_038946268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,702,870 - 44,718,388 (-)NCBI
mRatBN7.21342,150,604 - 42,166,120 (-)NCBI
RefSeq Acc Id: XM_039090343   ⟹   XP_038946271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,711,918 - 44,726,029 (-)NCBI
mRatBN7.21342,159,647 - 42,173,785 (-)NCBI
RefSeq Acc Id: XM_063272025   ⟹   XP_063128095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,702,870 - 44,725,633 (-)NCBI
RefSeq Acc Id: XM_063272026   ⟹   XP_063128096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,702,870 - 44,727,135 (-)NCBI
RefSeq Acc Id: XM_063272027   ⟹   XP_063128097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,683,499 - 44,726,029 (-)NCBI
RefSeq Acc Id: XM_063272029   ⟹   XP_063128099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,702,870 - 44,726,938 (-)NCBI
RefSeq Acc Id: XM_063272030   ⟹   XP_063128100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,699,743 - 44,725,634 (-)NCBI
RefSeq Acc Id: XM_063272031   ⟹   XP_063128101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,699,743 - 44,725,822 (-)NCBI
RefSeq Acc Id: XM_063272032   ⟹   XP_063128102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,702,870 - 44,718,388 (-)NCBI
RefSeq Acc Id: XM_063272033   ⟹   XP_063128103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,702,870 - 44,717,328 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001029136 (Get FASTA)   NCBI Sequence Viewer  
  NP_001029137 (Get FASTA)   NCBI Sequence Viewer  
  NP_536725 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249768 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249769 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249770 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249771 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249772 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767647 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946265 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946266 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946268 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946271 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128095 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128096 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128097 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128099 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128100 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128101 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128102 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128103 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41132 (Get FASTA)   NCBI Sequence Viewer  
  ACV65520 (Get FASTA)   NCBI Sequence Viewer  
  ACV65521 (Get FASTA)   NCBI Sequence Viewer  
  ACX42382 (Get FASTA)   NCBI Sequence Viewer  
  ACX42383 (Get FASTA)   NCBI Sequence Viewer  
  BAA96495 (Get FASTA)   NCBI Sequence Viewer  
  BAA96496 (Get FASTA)   NCBI Sequence Viewer  
  BAA96497 (Get FASTA)   NCBI Sequence Viewer  
  BAA96498 (Get FASTA)   NCBI Sequence Viewer  
  BAA96499 (Get FASTA)   NCBI Sequence Viewer  
  EDM09847 (Get FASTA)   NCBI Sequence Viewer  
  EDM09848 (Get FASTA)   NCBI Sequence Viewer  
  EDM09849 (Get FASTA)   NCBI Sequence Viewer  
  EDM09850 (Get FASTA)   NCBI Sequence Viewer  
  EDM09851 (Get FASTA)   NCBI Sequence Viewer  
  EDM09852 (Get FASTA)   NCBI Sequence Viewer  
  EDM09853 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005729
  ENSRNOP00000005729.3
  ENSRNOP00000030819
  ENSRNOP00000030819.4
  ENSRNOP00000044027
  ENSRNOP00000044027.4
  ENSRNOP00000044506.2
  ENSRNOP00000060044.3
  ENSRNOP00000082431
  ENSRNOP00000082431.1
  ENSRNOP00000093709.1
  ENSRNOP00055029386
  ENSRNOP00060027948
  ENSRNOP00065027454
GenBank Protein Q9JJH5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_536725   ⟸   NM_080477
- Peptide Label: isoform c
- UniProtKB: A6IBZ2 (UniProtKB/TrEMBL),   R9PXY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029137   ⟸   NM_001033965
- Peptide Label: isoform a
- UniProtKB: Q9JHL5 (UniProtKB/Swiss-Prot),   Q64297 (UniProtKB/Swiss-Prot),   Q9JJH4 (UniProtKB/Swiss-Prot),   Q9JJH5 (UniProtKB/Swiss-Prot),   A6IBZ4 (UniProtKB/TrEMBL),   A0A8I6GKS2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029136   ⟸   NM_001033964
- Peptide Label: isoform b
- UniProtKB: A6IBZ3 (UniProtKB/TrEMBL),   R9PXY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249771   ⟸   XM_006249709
- Peptide Label: isoform X6
- UniProtKB: A6IBZ2 (UniProtKB/TrEMBL),   R9PXY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249770   ⟸   XM_006249708
- Peptide Label: isoform X2
- UniProtKB: R9PXY6 (UniProtKB/TrEMBL),   A6IBZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249769   ⟸   XM_006249707
- Peptide Label: isoform X2
- UniProtKB: R9PXY6 (UniProtKB/TrEMBL),   A6IBZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249768   ⟸   XM_006249706
- Peptide Label: isoform X2
- UniProtKB: R9PXY6 (UniProtKB/TrEMBL),   A6IBZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249772   ⟸   XM_006249710
- Peptide Label: isoform X8
- UniProtKB: C9DRP6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767647   ⟸   XM_008769425
- Peptide Label: isoform X5
- UniProtKB: R9PXY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060044   ⟸   ENSRNOT00000067445
RefSeq Acc Id: ENSRNOP00000044506   ⟸   ENSRNOT00000050354
RefSeq Acc Id: ENSRNOP00000044027   ⟸   ENSRNOT00000050859
RefSeq Acc Id: ENSRNOP00000030819   ⟸   ENSRNOT00000037679
RefSeq Acc Id: ENSRNOP00000005729   ⟸   ENSRNOT00000005729
RefSeq Acc Id: XP_038946266   ⟸   XM_039090338
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GKS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946265   ⟸   XM_039090337
- Peptide Label: isoform X1
- UniProtKB: R9PXY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946268   ⟸   XM_039090340
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038946271   ⟸   XM_039090343
- Peptide Label: isoform X11
RefSeq Acc Id: ENSRNOP00000093709   ⟸   ENSRNOT00000101692
RefSeq Acc Id: ENSRNOP00000082431   ⟸   ENSRNOT00000117528
RefSeq Acc Id: XP_063128097   ⟸   XM_063272027
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063128101   ⟸   XM_063272031
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063128100   ⟸   XM_063272030
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063128096   ⟸   XM_063272026
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063128099   ⟸   XM_063272029
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063128095   ⟸   XM_063272025
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063128102   ⟸   XM_063272032
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063128103   ⟸   XM_063272033
- Peptide Label: isoform X10
Protein Domains
6-phosphofructo-2-kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJH5-F1-model_v2 AlphaFold Q9JJH5 1-557 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3309 AgrOrtholog
BioCyc Gene G2FUF-18369 BioCyc
BioCyc Pathway PWY66-423 [fructose 2,6-bisphosphate biosynthesis] BioCyc
BioCyc Pathway Image PWY66-423 BioCyc
Ensembl Genes ENSRNOG00000004162 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055021098 UniProtKB/Swiss-Prot
  ENSRNOG00060019223 UniProtKB/Swiss-Prot
  ENSRNOG00065020137 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005729 ENTREZGENE
  ENSRNOT00000005729.6 UniProtKB/Swiss-Prot
  ENSRNOT00000037679 ENTREZGENE
  ENSRNOT00000037679.7 UniProtKB/Swiss-Prot
  ENSRNOT00000050354.4 UniProtKB/TrEMBL
  ENSRNOT00000050859.5 UniProtKB/TrEMBL
  ENSRNOT00000067445.4 UniProtKB/TrEMBL
  ENSRNOT00000101692.1 UniProtKB/TrEMBL
  ENSRNOT00000117528 ENTREZGENE
  ENSRNOT00000117528.1 UniProtKB/Swiss-Prot
  ENSRNOT00055036175 UniProtKB/Swiss-Prot
  ENSRNOT00060034108 UniProtKB/Swiss-Prot
  ENSRNOT00065034284 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6Pfruct_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6Phosfructo_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_Pase_superF_clade-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_PPase_superfam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG/BPGM_mutase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24640 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24640 ENTREZGENE
PANTHER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 6PF2K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_Phos_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pfkfb2 PhenoGen
PIRSF 6PFK_2-Ptase UniProtKB/TrEMBL
PRINTS 6PFRUCTKNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PG_MUTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004162 RatGTEx
  ENSRNOG00055021098 RatGTEx
  ENSRNOG00060019223 RatGTEx
  ENSRNOG00065020137 RatGTEx
SMART PGAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53254 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GKS2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QNS5_RAT UniProtKB/TrEMBL
  A6IBZ2 ENTREZGENE, UniProtKB/TrEMBL
  A6IBZ3 ENTREZGENE, UniProtKB/TrEMBL
  A6IBZ4 ENTREZGENE, UniProtKB/TrEMBL
  A6IBZ8 ENTREZGENE, UniProtKB/TrEMBL
  C9DRP5_RAT UniProtKB/TrEMBL
  C9DRP6 ENTREZGENE, UniProtKB/TrEMBL
  D0EA88_RAT UniProtKB/TrEMBL
  D0EA89_RAT UniProtKB/TrEMBL
  F262_RAT UniProtKB/Swiss-Prot
  Q64297 ENTREZGENE
  Q9JHL5 ENTREZGENE
  Q9JJH4 ENTREZGENE
  Q9JJH5 ENTREZGENE
  R9PXY6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q64297 UniProtKB/Swiss-Prot
  Q9JHL5 UniProtKB/Swiss-Prot
  Q9JJH4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Pfkfb2  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2  Name updated 1299863 APPROVED
2002-06-10 Pfkfb2  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization intracellular 61489
gene_process regulatory molecule that controls glycolysis in all eukaryotic tissues by integrating hormonal and metabolic signals