Aqp3 (aquaporin 3 (Gill blood group)) - Rat Genome Database

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Gene: Aqp3 (aquaporin 3 (Gill blood group)) Rattus norvegicus
Symbol: Aqp3
Name: aquaporin 3 (Gill blood group)
RGD ID: 68428
Description: Enables glycerol channel activity and water channel activity. Involved in glycerol transmembrane transport and water transport. Located in basolateral plasma membrane. Biomarker of brain ischemia and hypothyroidism. Orthologous to human AQP3 (aquaporin 3 (Gill blood group)); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 31.4 kDa water channel protein; AQP-3; aquaglyceroporin-3; aquaporin 3; aquaporin-3; MGC156623
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2556,239,200 - 56,244,718 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,239,201 - 56,244,720 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx558,214,542 - 58,220,027 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0560,033,565 - 60,039,050 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0560,018,965 - 60,024,339 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0557,423,735 - 57,429,252 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl557,423,734 - 57,429,245 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0561,954,830 - 61,960,347 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4558,501,642 - 58,507,159 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1558,501,820 - 58,507,338 (-)NCBI
Celera554,836,731 - 54,842,234 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (ISO)
1,4-phenylenediamine  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-1,4-phenylenediamine  (ISO)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorogenic acid  (ISO)
choline  (ISO)
ciglitazone  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
Clofop  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
diprotium oxide  (EXP,ISO)
diquat  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
fenamic acid  (ISO)
fenofibrate  (EXP)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (EXP)
genistein  (EXP,ISO)
glucose  (ISO)
glycerol  (EXP,ISO)
hydroquinone  (ISO)
isoflavones  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lucanthone  (ISO)
LY294002  (ISO)
malvidin 3-O-beta-D-glucoside  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
mercaptoethanol  (ISO)
mercury dichloride  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (EXP,ISO)
morphine  (EXP)
Muraglitazar  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
Osajin  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
palmitoyl ethanolamide  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (EXP)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
petunidin 3-O-beta-D-glucoside  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
Pomiferin  (ISO)
proanthocyanidin  (ISO)
procyanidin B1  (ISO)
procyanidin B3  (ISO)
progesterone  (ISO)
propanal  (ISO)
puerarin  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
Rosavin  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
selenium atom  (ISO)
serotonin  (EXP,ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sulforaphane  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
thiourea  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
triacsin C  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)
water  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
basolateral plasma membrane  (IBA,IDA,IEA,ISO)
cell-cell junction  (IEA,ISO)
cytoplasm  (IEA,ISO)
nucleoplasm  (IEA,ISO)
plasma membrane  (IBA,ISO)

Molecular Function


References - curated
# Reference Title Reference Citation
1. Urinary concentrating defect in hypothyroid rats: role of sodium, potassium, 2-chloride co-transporter, and aquaporins. Cadnapaphornchai MA, etal., J Am Soc Nephrol 2003 Mar;14(3):566-74.
2. Cloning and expression of AQP3, a water channel from the medullary collecting duct of rat kidney. Echevarria M, etal., Proc Natl Acad Sci U S A 1994 Nov 8;91(23):10997-1001.
3. Human neuronal changes in brain edema and increased intracranial pressure. Faragó N, etal., Acta Neuropathol Commun. 2016 Aug 4;4(1):78. doi: 10.1186/s40478-016-0356-x.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells. Ishibashi K, etal., Proc Natl Acad Sci U S A 1994 Jul 5;91(14):6269-73.
7. Aquaporins in the kidney. Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
8. Downregulation of renal aquaporins in response to unilateral ureteral obstruction. Li C, etal., Am J Physiol Renal Physiol 2003 May;284(5):F1066-79.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus. Nejsum LN, etal., Am J Physiol Renal Physiol 2001 Apr;280(4):F715-26.
12. Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Nejsum LN, etal., Proc Natl Acad Sci U S A 2002 Jan 8;99(1):511-516.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Expression, localization, and regulation of aquaporin-1 to -3 in rat urothelia. Spector DA, etal., Am J Physiol Renal Physiol 2002 Jun;282(6):F1034-42.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Molecular characterization of a broad selectivity neutral solute channel. Tsukaguchi H, etal., J Biol Chem 1998 Sep 18;273(38):24737-43.
21. Temporal changes in expression of aquaporin-3, -4, -5 and -8 in rat brains after permanent focal cerebral ischemia. Yang M, etal., Brain Res. 2009 Sep 22;1290:121-32. Epub 2009 Jul 16.
Additional References at PubMed
PMID:1373524   PMID:1510932   PMID:7530250   PMID:9369468   PMID:9405233   PMID:9806845   PMID:9829975   PMID:10318966   PMID:10322639   PMID:10510269   PMID:10564231   PMID:10795927  
PMID:11001937   PMID:11034202   PMID:11035042   PMID:11076974   PMID:11382807   PMID:11573934   PMID:12042359   PMID:12084581   PMID:12477932   PMID:12522663   PMID:14521551   PMID:14605277  
PMID:14701836   PMID:15223838   PMID:15248066   PMID:15550389   PMID:15557451   PMID:15844003   PMID:15948717   PMID:16525162   PMID:16596446   PMID:17178220   PMID:17213730   PMID:17325454  
PMID:17429015   PMID:17943189   PMID:18202181   PMID:18501347   PMID:18511455   PMID:18543247   PMID:18718702   PMID:18762715   PMID:19515809   PMID:19545896   PMID:21178974   PMID:21251984  
PMID:21479884   PMID:21677414   PMID:21713710   PMID:22028046   PMID:22166655   PMID:22531364   PMID:22687538   PMID:23041062   PMID:23152856   PMID:24286754   PMID:24462679   PMID:25184686  
PMID:25766885   PMID:26231231   PMID:26367709   PMID:27525904   PMID:28525373   PMID:30384362   PMID:30420639   PMID:34099798   PMID:34657253  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2556,239,200 - 56,244,718 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,239,201 - 56,244,720 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx558,214,542 - 58,220,027 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0560,033,565 - 60,039,050 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0560,018,965 - 60,024,339 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0557,423,735 - 57,429,252 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl557,423,734 - 57,429,245 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0561,954,830 - 61,960,347 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4558,501,642 - 58,507,159 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1558,501,820 - 58,507,338 (-)NCBI
Celera554,836,731 - 54,842,234 (-)NCBICelera
Cytogenetic Map5q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38933,441,160 - 33,447,593 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl933,441,156 - 33,447,596 (-)EnsemblGRCh38hg38GRCh38
GRCh37933,441,158 - 33,447,591 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36933,431,158 - 33,437,590 (-)NCBINCBI36Build 36hg18NCBI36
Build 34933,431,161 - 33,437,590NCBI
Celera933,371,265 - 33,377,697 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef933,397,455 - 33,403,933 (-)NCBIHuRef
CHM1_1933,440,929 - 33,447,408 (-)NCBICHM1_1
T2T-CHM13v2.0933,459,659 - 33,466,091 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39441,092,724 - 41,098,183 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl441,092,722 - 41,098,183 (-)EnsemblGRCm39 Ensembl
GRCm38441,092,724 - 41,098,183 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl441,092,722 - 41,098,183 (-)EnsemblGRCm38mm10GRCm38
MGSCv37441,039,757 - 41,045,216 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36441,281,477 - 41,286,849 (-)NCBIMGSCv36mm8
Celera440,753,580 - 40,759,039 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map420.94NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554722,234,770 - 2,240,027 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554722,234,770 - 2,239,753 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1991,159,328 - 91,165,801 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0933,221,989 - 33,228,469 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1934,032,983 - 34,039,438 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl934,032,983 - 34,039,438 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11150,517,509 - 50,524,565 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1149,147,497 - 49,154,480 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01151,458,242 - 51,465,233 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1151,458,249 - 51,464,338 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11150,122,208 - 50,128,303 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01149,989,326 - 49,996,305 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01150,754,568 - 50,761,559 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947165,416,549 - 165,422,364 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365241,963,247 - 1,969,998 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365241,963,427 - 1,969,977 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1033,045,245 - 33,051,082 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11033,045,374 - 33,050,285 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21037,307,632 - 37,312,545 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11246,817,790 - 46,825,154 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603843,708,128 - 43,714,966 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473638,194,545 - 38,201,036 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473638,194,722 - 38,200,961 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Aqp3
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:274
Count of miRNA genes:182
Interacting mature miRNAs:213
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2556,239,687 - 56,239,862 (+)MAPPERmRatBN7.2
Rnor_6.0557,424,222 - 57,424,396NCBIRnor6.0
Rnor_5.0561,955,317 - 61,955,491UniSTSRnor5.0
RGSC_v3.4558,502,129 - 58,502,303UniSTSRGSC3.4
Celera554,837,218 - 54,837,392UniSTS
Cytogenetic Map5q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2556,239,267 - 56,239,478 (+)MAPPERmRatBN7.2
Rnor_6.0557,423,802 - 57,424,012NCBIRnor6.0
Rnor_5.0561,954,897 - 61,955,107UniSTSRnor5.0
RGSC_v3.4558,501,709 - 58,501,919UniSTSRGSC3.4
Celera554,836,798 - 54,837,008UniSTS
Cytogenetic Map5q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2556,240,081 - 56,241,431 (+)MAPPERmRatBN7.2
Rnor_6.0557,424,616 - 57,425,965NCBIRnor6.0
Rnor_5.0561,955,711 - 61,957,060UniSTSRnor5.0
RGSC_v3.4558,502,523 - 58,503,872UniSTSRGSC3.4
Celera554,837,612 - 54,838,947UniSTS
Cytogenetic Map5q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2556,240,085 - 56,240,955 (+)MAPPERmRatBN7.2
Rnor_6.0557,424,620 - 57,425,489NCBIRnor6.0
Rnor_5.0561,955,715 - 61,956,584UniSTSRnor5.0
RGSC_v3.4558,502,527 - 58,503,396UniSTSRGSC3.4
Celera554,837,616 - 54,838,471UniSTS
Cytogenetic Map5q22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 10 22 22 4 22 31 7 1
Low 2 14 9 2 9 2 2 2 15 4 23 10 2
Below cutoff 13 23 14 6 14 6 8 39 10 6


RefSeq Acc Id: ENSRNOT00000013803   ⟹   ENSRNOP00000013803
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl556,239,201 - 56,244,720 (-)Ensembl
Rnor_6.0 Ensembl557,423,734 - 57,429,245 (-)Ensembl
RefSeq Acc Id: NM_031703   ⟹   NP_113891
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2556,239,200 - 56,244,718 (-)NCBI
Rnor_6.0557,423,735 - 57,429,252 (-)NCBI
Rnor_5.0561,954,830 - 61,960,347 (-)NCBI
RGSC_v3.4558,501,642 - 58,507,159 (-)RGD
Celera554,836,731 - 54,842,234 (-)RGD
Protein Sequences
Protein RefSeqs NP_113891 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA53652 (Get FASTA)   NCBI Sequence Viewer  
  AAI27491 (Get FASTA)   NCBI Sequence Viewer  
  EDL98656 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013803
GenBank Protein P47862 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113891   ⟸   NM_031703
- UniProtKB: A0A0G2JSK0 (UniProtKB/TrEMBL),   A6IIT6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013803   ⟸   ENSRNOT00000013803

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47862-F1-model_v2 AlphaFold P47862 1-292 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693643
Promoter ID:EPDNEW_R4167
Type:single initiation site
Description:aquaporin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0557,429,260 - 57,429,320EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68428 AgrOrtholog
BioCyc Gene G2FUF-41579 BioCyc
Ensembl Genes ENSRNOG00000009797 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013803 ENTREZGENE
  ENSRNOT00000013803.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65133 UniProtKB/Swiss-Prot
  AQUAPORIN-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aqp3 PhenoGen
  MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009797 RatGTEx
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC207831
UniProt Secondary A0JPL5 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-27 Aqp3  aquaporin 3 (Gill blood group)  Aqp3  aquaporin 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Aqp3  aquaporin 3  Aqp3  aquaporin 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Aqp3  aquaporin 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in skin epithelium basal layer and kidney, and paw 70240
gene_expression expressed in the cell membrane of the urothelia 628378
gene_function water channel protein 68717
gene_process transports water across cell memebrane 68717
gene_process facilitates the transport of nonionic small solutes such as urea and glycerol 68717
gene_process involved in the bulk water movement across the urothelia 628378
gene_process regulates the epithelial cell volume and osmolality 628378
gene_regulation regulated by circulating vasopressin, expression increased in the bladder and ureter after dehydration 628378
gene_transcript gene has two possible start codons in-frame and contains a potential N-linked glycosylation signal with a poly(A) tail 68216