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Gene: AQP3 (aquaporin 3 (Gill blood group)) Pan paniscus

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Symbol:

AQP3

Name:

aquaporin 3 (Gill blood group)

RGD ID:

11720833

Description:

ENCODES a protein that exhibits polyol transmembrane transporter activity (ortholog); water channel activity (ortholog); INVOLVED IN cellular response to hypoxia (ortholog); establishment of localization in cell (ortholog); renal water absorption (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); brain edema (ortholog); brain ischemia (ortholog); FOUND IN basolateral plasma membrane (inferred); cell-cell junction (inferred); cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

aquaporin-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AQP3 (aquaporin 3 (Gill blood group))	NCBI	Ortholog
Mus musculus (house mouse):	Aqp3 (aquaporin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Aqp3 (aquaporin 3 (Gill blood group))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Aqp3 (aquaporin 3 (Gill blood group))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AQP3 (aquaporin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Aqp3 (aquaporin 3 (Gill blood group))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AQP3 (aquaporin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AQP3 (aquaporin 3 (Gill blood group))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Aqp3 (aquaporin 3 (Gill blood group))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	91,153,391 - 91,159,857 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	91,159,328 - 91,165,801 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	33,221,989 - 33,228,469 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	34,032,983 - 34,039,438 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	34,032,983 - 34,039,438 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia, Maroteaux type (ISO)

brain edema (ISO)

brain ischemia (ISO)

distal arthrogryposis type 1A (ISO)

Esophageal Neoplasms (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ISO)

galactosemia (ISO)

hypothyroidism (ISO)

Lymphatic Metastasis (ISO)

nephrogenic diabetes insipidus (ISO)

Ovarian Neoplasms (ISO)

paraplegia (ISO)

primary ciliary dyskinesia (ISO)

Skin Neoplasms (ISO)

squamous cell carcinoma (ISO)

Tongue Neoplasms (ISO)

urinary bladder cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to hypoxia (IEA,ISO)

establishment of localization in cell (IEA,ISO)

glycerol transmembrane transport (IEA)

odontogenesis (IEA)

polyol transmembrane transport (IEA)

positive regulation of immune system process (IEA)

renal water absorption (IEA,ISO)

response to ischemia (IEA,ISO)

response to retinoic acid (IEA)

transmembrane transport (IEA)

urea transmembrane transport (IEA)

urea transport (IEA,ISO)

water transport (IEA,ISO)

Cellular Component

basolateral plasma membrane (IEA)

cell-cell junction (IEA)

cytoplasm (IEA)

membrane (IEA)

nucleoplasm (IEA)

plasma membrane (IEA)

Molecular Function

channel activity (IEA)

glycerol channel activity (IEA)

identical protein binding (IEA)

polyol transmembrane transporter activity (ISO)

protein binding (ISO)

urea transmembrane transporter activity (IEA)

water channel activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

amiloride pharmacodynamics pathway (ISO)

bendroflumethiazide pharmacodynamics pathway (ISO)

bumetanide pharmacodynamics pathway (ISO)

chlorothiazide pharmacodynamics pathway (ISO)

chlorthalidone pharmacodynamics pathway (ISO)

cystinuria pathway (ISO)

E-cadherin signaling pathway (ISO)

eplerenone pharmacodynamics pathway (ISO)

etacrynic acid pharmacodynamics pathway (ISO)

furosemide pharmacodynamics pathway (ISO)

Hartnup disease pathway (ISO)

hydrochlorothiazide pharmacodynamics pathway (ISO)

hydroflumethiazide pharmacodynamics pathway (ISO)

iminoglycinuria pathway (ISO)

lysinuric protein intolerance pathway (ISO)

metolazone pharmacodynamics pathway (ISO)

spironolactone pharmacodynamics pathway (ISO)

torasemide pharmacodynamics pathway (ISO)

triamterene pharmacodynamics pathway (ISO)

trichlormethiazide pharmacodynamics pathway (ISO)

water transport pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

AQP3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	91,153,391 - 91,159,857 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	91,159,328 - 91,165,801 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	33,221,989 - 33,228,469 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	34,032,983 - 34,039,438 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	34,032,983 - 34,039,438 (-)	Ensembl	panpan1.1		panPan2

AQP3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	33,441,160 - 33,447,593 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	33,441,156 - 33,447,596 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	33,441,158 - 33,447,591 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	33,431,158 - 33,437,590 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	33,431,161 - 33,437,590	NCBI
Celera	9	33,371,265 - 33,377,697 (-)	NCBI		Celera
Cytogenetic Map	9	p13.3	NCBI
HuRef	9	33,397,455 - 33,403,933 (-)	NCBI		HuRef
CHM1_1	9	33,440,929 - 33,447,408 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	33,459,659 - 33,466,091 (-)	NCBI		T2T-CHM13v2.0

Aqp3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	41,092,724 - 41,098,183 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	41,092,722 - 41,098,183 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	41,092,724 - 41,098,183 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	41,092,722 - 41,098,183 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	41,039,757 - 41,045,216 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	41,281,477 - 41,286,849 (-)	NCBI		MGSCv36	mm8
Celera	4	40,753,580 - 40,759,039 (-)	NCBI		Celera
Cytogenetic Map	4	A5	NCBI
cM Map	4	20.94	NCBI

Aqp3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	61,035,165 - 61,040,683 (-)	NCBI		GRCr8
mRatBN7.2	5	56,239,200 - 56,244,718 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	56,239,201 - 56,244,720 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	58,214,542 - 58,220,027 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	60,033,565 - 60,039,050 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	60,018,965 - 60,024,339 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	57,423,735 - 57,429,252 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	57,423,734 - 57,429,245 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	61,954,830 - 61,960,347 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	58,501,642 - 58,507,159 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	58,501,820 - 58,507,338 (-)	NCBI
Celera	5	54,836,731 - 54,842,234 (-)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

Aqp3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955472	2,234,770 - 2,240,027 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955472	2,234,770 - 2,239,753 (+)	NCBI	ChiLan1.0	ChiLan1.0

AQP3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	50,517,509 - 50,524,565 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	49,147,497 - 49,154,480 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	51,458,242 - 51,465,233 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	51,458,249 - 51,464,338 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	50,122,208 - 50,128,303 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	49,989,326 - 49,996,305 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	50,754,568 - 50,761,559 (-)	NCBI		UU_Cfam_GSD_1.0

Aqp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	165,416,549 - 165,422,364 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	1,963,247 - 1,969,998 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	1,963,427 - 1,969,977 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AQP3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	33,045,245 - 33,051,082 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	33,045,374 - 33,050,285 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	37,307,632 - 37,312,545 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AQP3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	46,817,790 - 46,825,154 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	43,708,128 - 43,714,966 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aqp3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	38,194,545 - 38,201,036 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624736	38,194,722 - 38,200,961 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003830123	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_024930109	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000062153 ⟹ ENSPPAP00000039243

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	9	34,032,983 - 34,039,438 (-)	Ensembl

RefSeq Acc Id:

XM_003830123 ⟹ XP_003830171

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	11	91,153,391 - 91,159,857 (+)	NCBI
NHGRI_mPanPan1	9	91,159,328 - 91,165,801 (+)	NCBI
Mhudiblu_PPA_v0	9	33,221,989 - 33,228,465 (-)	NCBI
PanPan1.1	9	34,032,983 - 34,039,438 (-)	NCBI

Sequence:

show sequence

GCGCTCCTATAAAGGGAGCCACCAGCGCTGGAGGCCGCTGCTCGCTGCGCCGCCGCCTCCCGCC
ACCCCTTCCCGCCCGACAGCGCCGCCGCCTGCCCCGCCATGGGTCGACAGAAGGAGCTGGTGTC
CCGCTGCGGGGAGATGCTCCACATCCGCTACCGGCTGCTCCGACAGGCGCTGGCCGAGTGCCTG
GGGACCCTCATCCTCGTGATGTTTGGCTGTGGCTCCGTGGCCCAGGTTGTGCTCAGCCGGGGCA
CCCACGGTGGTTTCCTCACCATCAACCTGGCCTTTGGCTTTGCTGTCACTCTGGGCATCCTCAT
CGCTGGCCAGGTCTCTGGGGCCCACCTGAACCCTGCCGTGACCTTTGCCATGTGCTTCCTGGCT
CGTGAGCCCTGGATCAAGCTGCCCATCTACACCCTGGCACAGACGCTGGGAGCCTTCTTGGGTG
CTGGAATAGTTTTTGGGCTGTATTATGATGCAATCTGGCACTTTGGCGACAACCAGCTTTATGT
TTCGGGCCCCAATGGCACAGCCGGCATCTTTGCTACCTACCCCTCTGGACACTTGGATATGATC
AATGGCTTCTTTGACCAGTTCATAGGCACAGCCTCCCTTATCGTGTGTGTGCTGGCCATTGTTG
ACCCCTACAACAACCCCGTCCCCCGAGGCCTGGAGGCCTTCACCGTGGGCCTGGTGGTCCTGGT
CATTGGCACCTCCATGGGCTTCAACTCCGGCTATGCCGTCAACCCTGCCCGGGACTTTGGCCCC
CGCCTTTTTACAGCCCTTGCGGGCTGGGGCTCTGCAGTCTTCACGACCGGCCAGCATTGGTGGT
GGGTGCCCATCGTGTCCCCACTCCTGGGCTCCATTGCGGGTGTCTTCGTGTACCAGCTGATGAT
CGGCTGCCACCTGGAGCAGCCCCCACCCTCCAACGAGGAAGAGAATGTGAAGCTGGCCCATGTG
AAGCACAAGGAGCAGATCTGAGTGGGCAGGGGCCATCTCCCCACTCTGCTGCCCTGGCCTTGAG
CATCCACAGACTGTCCAAGGGCCACTCCCAAGAAGCCCCCTTCACGATCCACCCTTTCAGGCTA
AGGAGCTCCCTATCTACCCTCACCCCACGAGACAGCCCCTTCAGGATTTCCACTGGACCTTGCC
CAAATAGCACCTTAGGCCACTGCCCCTAAGCTGGGGTGGAACCGGAATTTGGGTCAATACATCC
TTTTGTCTCCCAAGGGAAGAGAATGGGCAGCAGGTATGTGTGTGTGTGCATATGTGTGCAGGGG
TGTGTGTGTGTGTGTGTGTGTGTGTGGTTTCCCAGATATTCAGGGCAAGGGACCAGTCGGAAGG
GATTCCGGCTATTGGGGGAGCCCAGAGACAGGGGAAGGCAGCCTGTCCATCTGTGCATAAGGAG
AGGAAAGTTCCAGGGTGTGTATGTTTCAAGGGCTTCACATGGAGGAGCTGCAGATAGATATGTG
TTTCTGTGTATGTGTATGTCTGCCTTTTTTTCTAAGTGGGGGCTTCTACAGGCTTTTGGGAAGT
AGGGTGGATGTGGGTAGGGCTGGGAGGAGGGGGCCACAGCTTAGGTTTGGAGCTCTGGATGTAC
ATACATAAGTAGGAGCAGTGGGAAGTGTTTCTGTCATAATGCAGGCATGAAGGGTGGAGTGAAG
TCAGGTCATAAGTTTCATGTTTGCTTTTGTTTTGTTTTGTTTTTAATGTACGTAGCAGATGTTA
CAGTCTTAGGGATCCGGGATGGGAGACCCCACTTTAGAAAGGGTCGTCACTCCTTTAATCCTCT
ACTCAACAATGTACTCTTTTATCTTTTATATTTAAAAAAATTAAATAAATATGTGCCTAAAACC
TCCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003830171	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000039243
	ENSPPAP00000039243.1

RefSeq Acc Id:

XP_003830171 ⟸ XM_003830123

- UniProtKB:

A0A2R9CE25 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFG
FAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIW
HFGDNQLYVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEA
FTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIA
GVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI

hide sequence

Ensembl Acc Id:

ENSPPAP00000039243 ⟸ ENSPPAT00000062153

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000042338	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000062153.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1080.10	UniProtKB/TrEMBL
InterPro	Aquaporin-like	UniProtKB/TrEMBL
	Aquaporin_3	UniProtKB/TrEMBL
	MIP	UniProtKB/TrEMBL
	MIP/Aquaporin	UniProtKB/TrEMBL
	MIP_CS	UniProtKB/TrEMBL
KEGG Report	pps:100977111	UniProtKB/TrEMBL
NCBI Gene	AQP3	ENTREZGENE
PANTHER	AQUAPORIN OR AQUAGLYCEROPORIN RELATED	UniProtKB/TrEMBL
	AQUAPORIN-3	UniProtKB/TrEMBL
Pfam	MIP	UniProtKB/TrEMBL
PRINTS	AQUAPORIN3	UniProtKB/TrEMBL
	MINTRINSICP	UniProtKB/TrEMBL
PROSITE	MIP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF81338	UniProtKB/TrEMBL
UniProt	A0A2R9CE25	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)