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Gene: Aqp3 (aquaporin 3) Mus musculus
Symbol: Aqp3
Name: aquaporin 3
RGD ID: 68639
Description: Predicted to have glycerol channel activity; urea transmembrane transporter activity; and water channel activity. Involved in several processes, including cellular response to oxygen-glucose deprivation; glycerol transport; and renal water absorption. Localizes to basolateral plasma membrane and cell-cell junction. Is expressed in several structures, including alimentary system; early conceptus; gonad; lateral plate mesoderm; and metanephros. Used to study nephrogenic diabetes insipidus. Orthologous to human AQP3 (aquaporin 3 (Gill blood group)); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AQP-2; AQP-3; aquaglyceroporin-3; aquaporin-3
Homo sapiens (human) : AQP3 (aquaporin 3 (Gill blood group))  HGNC  Alliance
Rattus norvegicus (Norway rat) : Aqp3 (aquaporin 3 (Gill blood group))  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aqp3 (aquaporin 3 (Gill blood group))
Pan paniscus (bonobo/pygmy chimpanzee) : AQP3 (aquaporin 3 (Gill blood group))
Canis lupus familiaris (dog) : AQP3 (aquaporin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aqp3 (aquaporin 3 (Gill blood group))
Sus scrofa (pig) : AQP3 (aquaporin 3)
Chlorocebus sabaeus (African green monkey) : AQP3 (aquaporin 3 (Gill blood group))
Heterocephalus glaber (naked mole-rat) : Aqp3 (aquaporin 3 (Gill blood group))
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl441,092,722 - 41,098,183 (-)EnsemblGRCm38mm10GRCm38
GRCm38441,092,724 - 41,098,183 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37441,039,757 - 41,045,216 (-)NCBIGRCm37mm9NCBIm37
MGSCv36441,281,477 - 41,286,849 (-)NCBImm8
Celera440,753,580 - 40,759,039 (-)NCBICelera
Cytogenetic Map4A5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Aqp3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68639
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.