Tac1 (tachykinin, precursor 1) - Rat Genome Database

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Gene: Tac1 (tachykinin, precursor 1) Rattus norvegicus
Analyze
Symbol: Tac1
Name: tachykinin, precursor 1
RGD ID: 3807
Description: Enables substance P receptor binding activity. Involved in several processes, including learning or memory; positive regulation of cell communication; and positive regulation of stress fiber assembly. Located in extracellular space. Used to study central sleep apnea and pulmonary hypertension. Biomarker of colitis and respiratory syncytial virus infectious disease. Orthologous to human TAC1 (tachykinin precursor 1); INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: VALIDATED
Previously known as: PPT; Ppt5fl; PPTA3; protachykinin-1; RATPPTA3; TAC; Tachykinin (substance P neurokinin A neuropeptide K neuropeptide gamma); Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma); tachykinin 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2435,679,183 - 35,687,180 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl435,679,704 - 35,687,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx440,638,023 - 40,645,989 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0436,564,213 - 36,572,177 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0434,981,526 - 34,989,526 (+)NCBIRnor_WKY
Rnor_6.0433,638,853 - 33,646,819 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl433,638,709 - 33,646,819 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0433,499,891 - 33,507,857 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4432,649,666 - 32,657,632 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1432,768,205 - 32,776,170 (+)NCBI
Celera431,183,136 - 31,191,779 (+)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-amphetamine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-nitropropanoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetylcholine  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
alfuzosin  (EXP)
allyl isothiocyanate  (EXP)
ammonium chloride  (EXP)
amoxapine  (EXP)
amphetamine  (EXP)
Anetholtrithion  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apomorphine  (EXP)
aprepitant  (ISO)
arsenite(3-)  (ISO)
ATP  (EXP)
baclofen  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
Botulinum toxin type A  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP)
capsaicin  (EXP,ISO)
capsazepine  (EXP,ISO)
carbamazepine  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
clomipramine  (EXP)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
CP-96345(1+)  (EXP,ISO)
Cuprizon  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (EXP)
desipramine  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazepam  (EXP)
diazinon  (EXP)
dieldrin  (EXP)
dioxygen  (EXP)
diprotium oxide  (EXP)
disodium cromoglycate  (EXP)
dizocilpine maleate  (EXP)
dobutamine  (ISO)
dodecane  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fluphenazine  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
furan  (EXP)
gabapentin  (EXP)
genistein  (EXP)
ginsenoside Re  (ISO)
Goe 6976  (EXP)
GW 4064  (ISO)
haloperidol  (EXP)
herbimycin  (EXP)
histamine  (EXP,ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
icatibant  (EXP)
iloprost  (EXP)
imipramine  (EXP)
indometacin  (EXP)
isoprenaline  (EXP)
kainic acid  (EXP)
Kallidin  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP,ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
mianserin  (EXP)
misoprostol  (EXP)
monosodium L-glutamate  (ISO)
morphine  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-1,4-benzoquinone imine  (EXP)
N-Nitrosopyrrolidine  (ISO)
N-Vanillyloleamide  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (EXP)
nedocromil  (ISO)
nimesulide  (EXP)
nitroglycerin  (EXP)
nizatidine  (ISO)
nonane  (EXP)
Norbinaltorphimine  (ISO)
NS-398  (EXP)
O-methyleugenol  (ISO)
Olopatadine hydrochloride  (ISO)
omega-conotoxin GVIA  (EXP)
oxaliplatin  (EXP)
oxidopamine  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
PCB138  (ISO)
pemirolast  (EXP)
phencyclidine  (ISO)
phenylarsine oxide  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 12,13-dibutanoate  (EXP)
phosphoramidon  (EXP)
piperine  (EXP)
pirinixic acid  (ISO)
potassium atom  (EXP)
potassium chloride  (EXP,ISO)
potassium dichromate  (ISO)
pregabalin  (EXP)
progesterone  (EXP)
prostaglandin D2  (EXP)
prostaglandin E2  (EXP)
quercetin  (ISO)
quinpirole  (EXP)
ranitidine  (ISO)
reserpine  (EXP)
resiniferatoxin  (ISO)
rofecoxib  (ISO)
SB 203580  (EXP)
SB 431542  (EXP,ISO)
scopolamine  (EXP)
serotonin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
SKF 38393  (EXP)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sorbinil  (EXP)
streptozocin  (EXP)
sucrose  (EXP)
T-2 toxin  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP)
toluene 2,6-diisocyanate  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
U-73122  (EXP)
U69593  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
water  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Thiorphan-induced survival and proliferation of rat thymocytes by activation of Akt/survivin pathway and inhibition of caspase-3 activity. Amantini C, etal., J Pharmacol Exp Ther. 2008 Oct;327(1):215-25. Epub 2008 Jul 11.
2. Direct evidence for the interaction of neurokinin A with the tachykinin NK(1) receptor in tissue. Bremer AA, etal., Eur J Pharmacol. 2001 Jul 6;423(2-3):143-7.
3. Hemodynamic effects of substance P and its receptor antagonist RP67580 in anesthetized rats with carbon tetrachloride-induced cirrhosis. Cardenas A, etal., Scand J Gastroenterol. 2008 Mar;43(3):328-33.
4. Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma. Carter MS and Krause JE, J Neurosci 1990 Jul;10(7):2203-14.
5. Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation. Cattaruzza F, etal., Br J Pharmacol. 2009 Feb 16.
6. Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin. Caudle RM, etal., BMC Neurosci. 2007 May 10;8:30.
7. The sequence of 5' flanking DNA from the rat preprotachykinin gene; analysis of putative transcription factor binding sites. Chapman K, etal., Biochim Biophys Acta 1993 Mar 20;1172(3):361-3.
8. Exercise reduces GABA synaptic input onto nucleus tractus solitarii baroreceptor second-order neurons via NK1 receptor internalization in spontaneously hypertensive rats. Chen CY, etal., J Neurosci. 2009 Mar 4;29(9):2754-61.
9. Tachykinin dysfunction attenuates monocrotaline-induced pulmonary hypertension. Chen MJ and Lai YL, Toxicol Appl Pharmacol. 2003 Mar 15;187(3):178-85.
10. Substance P and its receptor neurokinin 1 expression in asthmatic airways. Chu HW, etal., J Allergy Clin Immunol. 2000 Oct;106(4):713-22.
11. Spatial and temporal expression of tachykinins and NK1- and NK2-receptor gene during TNB induced colitis in rats. Evangelista S, etal., Neuropeptides. 2008 Oct-Dec;42(5-6):663-70. Epub 2008 Aug 19.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Substance P stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptors. Goto T, etal., Neuropeptides. 2007 Feb;41(1):25-31. Epub 2007 Jan 3.
15. Identification and cDNA sequence of delta-preprotachykinin, a fourth splicing variant of the rat substance P precursor. Harmar AJ, etal., FEBS Lett 1990 Nov 26;275(1-2):22-4.
16. Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies. Juszczak M, etal., J Physiol Pharmacol. 2007 Dec;58(4):829-43.
17. Neuropeptide K stimulates corticosterone release in the rat. Kalra PS and Kalra SP, Brain Res. 1993 May 7;610(2):330-3.
18. Sequence analysis of cloned cDNA for rat substance P precursor: existence of a third substance P precursor. Kawaguchi Y, etal., Biochem Biophys Res Commun 1986 Sep 30;139(3):1040-6.
19. Effects of substance P microinjections into the globus pallidus and central nucleus of amygdala on passive avoidance learning in rats. Kertes E, etal., Behav Brain Res. 2009 Mar 17;198(2):397-403. Epub 2008 Nov 24.
20. Substance P is involved in the cutaneous blood flow increase response to sympathetic nerve stimulation in persistently inflamed rats. Koeda T, etal., J Physiol Sci. 2007 Dec;57(6):361-6. Epub 2007 Dec 4.
21. Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A. Krause JE, etal., Proc Natl Acad Sci U S A 1987 Feb;84(3):881-5.
22. The effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis. Lau HY and Bhatia M, J Pathol. 2006 Feb;208(3):364-71.
23. Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure. Li PC, etal., Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L912-20. Epub 2008 Mar 7.
24. Unilateral ablation of pre-Botzinger complex disrupts breathing during sleep but not wakefulness. McKay LC and Feldman JL, Am J Respir Crit Care Med. 2008 Jul 1;178(1):89-95. Epub 2008 Apr 17.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Physiological and morphological properties of, and effect of substance P on, neurons in the A7 catecholamine cell group in rats. Min MY, etal., Neuroscience. 2008 Jun 2;153(4):1020-33. Epub 2008 Mar 19.
27. Cardiovascular roles of tachykinin peptides in the nucleus tractus solitarii of rats. Nagashima A, etal., Brain Res. 1989 May 22;487(2):392-6.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Tachykinin regulation of cholinergic transmission in the limbic/prefrontal territory of the rat dorsal striatum: implication of new neurokinine 1-sensitive receptor binding site and interaction with enkephalin/mu opioid receptor transmission. Perez S, etal., J Neurochem. 2007 Dec;103(6):2153-63. Epub 2007 Oct 18.
30. The role of the N-terminal and mid-region residues of substance P in regulating functional selectivity at the tachykinin NK1 receptor. Perrine SA, etal., Eur J Pharmacol. 2008 Sep 11;592(1-3):1-6. Epub 2008 Jul 2.
31. Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs. Piedimonte G, etal., Am J Physiol. 1999 Oct;277(4 Pt 1):L831-40.
32. Neurokinin-1 receptor and substance P messenger RNA levels increase during intraabdominal adhesion formation. Reed KL, etal., J Surg Res 2002 Nov;108(1):165-72.
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene. Sio SW, etal., Am J Respir Crit Care Med. 2010 Jan 1;181(1):36-46. Epub 2009 Oct 1.
35. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
36. Decreased substance P and NK1 receptor immunoreactivity and function in the spinal cord dorsal horn of morphine-treated neonatal rats. Thomson LM, etal., J Pain. 2008 Jan;9(1):11-9. Epub 2007 Oct 24.
37. Substance P regulates migration in rat intestinal epithelial cells. Turner DJ, etal., Ann Surg. 2007 Mar;245(3):408-14.
38. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
39. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
40. TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats. Wang Y, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1517-23. Epub 2008 Mar 12.
41. Interdependent regulation of afferent renal nerve activity and renal function: role of transient receptor potential vanilloid type 1, neurokinin 1, and calcitonin gene-related peptide receptors. Xie C, etal., J Pharmacol Exp Ther. 2008 Jun;325(3):751-7. Epub 2008 Mar 25.
42. Paracrine-like excitation of low-threshold mechanoceptive C-fibers innervating rat hairy skin is mediated by substance P via NK-1 receptors. Zhang SH, etal., Brain Res Bull. 2008 Jan 31;75(1):138-45. Epub 2007 Sep 7.
Additional References at PubMed
PMID:1317267   PMID:2218531   PMID:2809597   PMID:7519424   PMID:7521790   PMID:8889548   PMID:8957234   PMID:9537322   PMID:9853118   PMID:11805341   PMID:11882578   PMID:11950831  
PMID:11959652   PMID:12074933   PMID:12084526   PMID:12172789   PMID:12183023   PMID:12372698   PMID:12458035   PMID:12489754   PMID:12574450   PMID:12578120   PMID:12620366   PMID:12632517  
PMID:12716968   PMID:12746258   PMID:12888222   PMID:12892378   PMID:14511128   PMID:14552872   PMID:14578115   PMID:14654230   PMID:14684370   PMID:14724197   PMID:15159534   PMID:15879482  
PMID:15978559   PMID:15987503   PMID:15992924   PMID:16198417   PMID:16284585   PMID:16399878   PMID:16477146   PMID:16647007   PMID:16763782   PMID:17101218   PMID:17314299   PMID:17336102  
PMID:17437961   PMID:17492626   PMID:17512547   PMID:17540463   PMID:17655832   PMID:17686587   PMID:17868995   PMID:17952636   PMID:17989135   PMID:18079587   PMID:18208479   PMID:18308827  
PMID:18418359   PMID:18551569   PMID:18580444   PMID:18603306   PMID:18607539   PMID:18615578   PMID:18673452   PMID:18679163   PMID:18945947   PMID:19000921   PMID:19015883   PMID:19125373  
PMID:19283865   PMID:19341730   PMID:19344710   PMID:19429049   PMID:19464118   PMID:19467322   PMID:19490080   PMID:19500558   PMID:19545608   PMID:19575822   PMID:19743505   PMID:19906978  
PMID:19934806   PMID:20074214   PMID:20139325   PMID:20140043   PMID:20218316   PMID:20490673   PMID:20535049   PMID:20540103   PMID:20546710   PMID:20690045   PMID:20865295   PMID:20942583  
PMID:21377453   PMID:21554904   PMID:21611833   PMID:21685692   PMID:21689789   PMID:21809559   PMID:21820035   PMID:21877901   PMID:21908647   PMID:22418790   PMID:22525132   PMID:22531375  
PMID:22559732   PMID:22762361   PMID:22763971   PMID:22765994   PMID:22825006   PMID:23809436   PMID:24010178   PMID:24045094   PMID:24307802   PMID:24760869   PMID:24877063   PMID:25001955  
PMID:25095383   PMID:25550118   PMID:25751638   PMID:25914462   PMID:26349209   PMID:26762802   PMID:27431609   PMID:27706667   PMID:28337884   PMID:28399671   PMID:28500728   PMID:28685530  
PMID:28791754   PMID:30518958   PMID:31922222   PMID:33212101   PMID:35008014  


Genomics

Comparative Map Data
Tac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2435,679,183 - 35,687,180 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl435,679,704 - 35,687,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx440,638,023 - 40,645,989 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0436,564,213 - 36,572,177 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0434,981,526 - 34,989,526 (+)NCBIRnor_WKY
Rnor_6.0433,638,853 - 33,646,819 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl433,638,709 - 33,646,819 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0433,499,891 - 33,507,857 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4432,649,666 - 32,657,632 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1432,768,205 - 32,776,170 (+)NCBI
Celera431,183,136 - 31,191,779 (+)NCBICelera
Cytogenetic Map4q21NCBI
TAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38797,732,086 - 97,740,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl797,732,084 - 97,740,472 (+)EnsemblGRCh38hg38GRCh38
GRCh37797,361,398 - 97,369,784 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36797,199,311 - 97,207,720 (+)NCBINCBI36Build 36hg18NCBI36
Build 34797,006,025 - 97,014,433NCBI
Celera792,055,970 - 92,064,483 (+)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef791,962,648 - 91,971,157 (+)NCBIHuRef
CHM1_1797,291,306 - 97,299,818 (+)NCBICHM1_1
T2T-CHM13v2.0798,961,638 - 98,970,024 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2796,683,759 - 96,692,272 (+)NCBI
Tac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3967,555,061 - 7,562,978 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl67,554,879 - 7,565,834 (+)EnsemblGRCm39 Ensembl
GRCm3867,555,061 - 7,562,978 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl67,554,879 - 7,565,834 (+)EnsemblGRCm38mm10GRCm38
MGSCv3767,505,071 - 7,512,973 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3667,505,071 - 7,512,973 (+)NCBIMGSCv36mm8
Celera67,693,231 - 7,701,130 (+)NCBICelera
Cytogenetic Map6A1NCBI
cM Map63.31NCBI
Tac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543213,991,414 - 13,999,728 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543213,991,647 - 13,999,665 (+)NCBIChiLan1.0ChiLan1.0
TAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan17163,826,347 - 163,834,906 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0789,675,834 - 89,684,391 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17103,257,450 - 103,266,005 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7103,257,501 - 103,266,389 (+)Ensemblpanpan1.1panPan2
TAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11422,631,106 - 22,640,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1422,632,642 - 22,640,258 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1422,207,754 - 22,215,926 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01422,451,048 - 22,459,223 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11422,597,269 - 22,605,445 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01422,330,414 - 22,338,555 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01422,594,017 - 22,602,196 (+)NCBIUU_Cfam_GSD_1.0
Tac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511835,921,952 - 35,930,508 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365852,932,727 - 2,941,384 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365852,932,783 - 2,941,141 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl977,197,536 - 77,206,523 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1977,197,403 - 77,206,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2984,764,564 - 84,773,747 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12151,339,085 - 51,347,561 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2151,339,095 - 51,347,550 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604253,024,229 - 53,032,700 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248134,542,011 - 4,550,486 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248134,542,226 - 4,550,378 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tac1
194 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:764
Count of miRNA genes:207
Interacting mature miRNAs:239
Transcripts:ENSRNOT00000009888, ENSRNOT00000034719, ENSRNOT00000052333
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
8655949Rf62Renal function QTL 6222blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)43443011944463908Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat

Markers in Region
D4Mgh31  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0433,641,609 - 33,641,941NCBIRnor6.0
Rnor_5.0433,502,647 - 33,502,979UniSTSRnor5.0
RGSC_v3.4432,652,422 - 32,652,754UniSTSRGSC3.4
Celera431,186,569 - 31,186,901UniSTS
Cytogenetic Map4q21UniSTS
D4Wox30  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0433,637,803 - 33,637,931NCBIRnor6.0
Rnor_5.0433,498,841 - 33,498,969UniSTSRnor5.0
RGSC_v3.4432,648,616 - 32,648,744UniSTSRGSC3.4
Celera431,182,086 - 31,182,214UniSTS
Cytogenetic Map4q21UniSTS
RH127708  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0433,646,516 - 33,646,709NCBIRnor6.0
Rnor_5.0433,507,554 - 33,507,747UniSTSRnor5.0
RGSC_v3.4432,657,329 - 32,657,522UniSTSRGSC3.4
Celera431,191,476 - 31,191,669UniSTS
RH 3.4 Map4212.0UniSTS
Cytogenetic Map4q21UniSTS
RH136646  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0433,645,908 - 33,646,087NCBIRnor6.0
Rnor_5.0433,506,946 - 33,507,125UniSTSRnor5.0
RGSC_v3.4432,656,721 - 32,656,900UniSTSRGSC3.4
Celera431,190,868 - 31,191,047UniSTS
RH 3.4 Map4212.4UniSTS
Cytogenetic Map4q21UniSTS


Related Rat Strains
The following Strains have been annotated to Tac1


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 64
Low 2 7 7 10 13 9
Below cutoff 12 6 4 7 4 3 3 4 20 2 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001124768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001124769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001124770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA818532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC128514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L07328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000009888   ⟹   ENSRNOP00000009888
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl433,638,709 - 33,646,819 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000034719   ⟹   ENSRNOP00000033246
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl433,638,853 - 33,646,817 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000052333   ⟹   ENSRNOP00000048764
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl433,638,853 - 33,646,817 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108392
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl435,679,704 - 35,687,178 (+)Ensembl
RefSeq Acc Id: NM_001124768   ⟹   NP_001118240
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2435,679,183 - 35,687,180 (+)NCBI
Rnor_6.0433,638,853 - 33,646,819 (+)NCBI
Rnor_5.0433,499,891 - 33,507,857 (+)NCBI
RGSC_v3.4432,649,666 - 32,657,632 (+)RGD
Celera431,183,136 - 31,191,779 (+)RGD
Sequence:
RefSeq Acc Id: NM_001124769   ⟹   NP_001118241
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2435,679,183 - 35,687,180 (+)NCBI
Rnor_6.0433,638,853 - 33,646,819 (+)NCBI
Rnor_5.0433,499,891 - 33,507,857 (+)NCBI
RGSC_v3.4432,649,666 - 32,657,632 (+)RGD
Celera431,183,136 - 31,191,779 (+)RGD
Sequence:
RefSeq Acc Id: NM_001124770   ⟹   NP_001118242
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2435,679,183 - 35,687,180 (+)NCBI
Rnor_6.0433,638,853 - 33,646,819 (+)NCBI
Rnor_5.0433,499,891 - 33,507,857 (+)NCBI
RGSC_v3.4432,649,666 - 32,657,632 (+)RGD
Celera431,183,136 - 31,191,779 (+)RGD
Sequence:
RefSeq Acc Id: NM_012666   ⟹   NP_036798
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2435,679,183 - 35,687,180 (+)NCBI
Rnor_6.0433,638,853 - 33,646,819 (+)NCBI
Rnor_5.0433,499,891 - 33,507,857 (+)NCBI
RGSC_v3.4432,649,666 - 32,657,632 (+)RGD
Celera431,183,136 - 31,191,779 (+)RGD
Sequence:
RefSeq Acc Id: XM_039107066   ⟹   XP_038962994
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2435,680,115 - 35,687,180 (+)NCBI
RefSeq Acc Id: XM_039107067   ⟹   XP_038962995
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2435,680,162 - 35,687,180 (+)NCBI
RefSeq Acc Id: XM_039107068   ⟹   XP_038962996
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2435,680,076 - 35,687,180 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036798   ⟸   NM_012666
- Peptide Label: isoform a precursor
- UniProtKB: Q6LD93 (UniProtKB/Swiss-Prot),   P06767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001118240   ⟸   NM_001124768
- Peptide Label: isoform b precursor
- UniProtKB: P06767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001118241   ⟸   NM_001124769
- Peptide Label: isoform c precursor
- UniProtKB: P06767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001118242   ⟸   NM_001124770
- Peptide Label: isoform d precursor
- UniProtKB: P06767 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009888   ⟸   ENSRNOT00000009888
RefSeq Acc Id: ENSRNOP00000033246   ⟸   ENSRNOT00000034719
RefSeq Acc Id: ENSRNOP00000048764   ⟸   ENSRNOT00000052333
RefSeq Acc Id: XP_038962996   ⟸   XM_039107068
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038962994   ⟸   XM_039107066
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038962995   ⟸   XM_039107067
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06767-F1-model_v2 AlphaFold P06767 1-130 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692868
Promoter ID:EPDNEW_R3393
Type:single initiation site
Name:Tac1_1
Description:tachykinin, precursor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0433,638,841 - 33,638,901EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3807 AgrOrtholog
BioCyc Gene G2FUF-45674 BioCyc
Ensembl Genes ENSRNOG00000007374 Ensembl
  ENSRNOG00000067502 Ensembl
InterPro Tachy_Neuro_lke_CS UniProtKB/Swiss-Prot
  Tachykinin_dom UniProtKB/Swiss-Prot
  Tachykinin_fam UniProtKB/Swiss-Prot
KEGG Report rno:24806 UniProtKB/Swiss-Prot
NCBI Gene 24806 ENTREZGENE
PANTHER PROTACHYKININ-1 UniProtKB/Swiss-Prot
  TACHYKININ UniProtKB/Swiss-Prot
Pfam Tachykinin UniProtKB/Swiss-Prot
PhenoGen Tac1 PhenoGen
PRINTS PROTACHYKNIN UniProtKB/Swiss-Prot
PROSITE TACHYKININ UniProtKB/Swiss-Prot
SMART SM00203 UniProtKB/Swiss-Prot
TIGR TC205233
UniProt P06767 ENTREZGENE
  Q6LD93 ENTREZGENE
  TKN1_RAT UniProtKB/Swiss-Prot
UniProt Secondary P08856 UniProtKB/Swiss-Prot
  P08857 UniProtKB/Swiss-Prot
  P22356 UniProtKB/Swiss-Prot
  Q6LD93 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-03-06 Tac1  tachykinin, precursor 1  Tac1  tachykinin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Tac1  Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in uterine tumors 70557
gene_expression expressed in uterus 70348
gene_expression expressed in uterus 70557