|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Oligopeptides analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Oligopeptides analog results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:24875536 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Atg12 |
autophagy related 12 |
decreases expression |
ISO |
Oligopeptides analog results in decreased expression of ATG12 protein |
CTD |
PMID:24875536 |
|
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
|
|
G |
Atg3 |
autophagy related 3 |
increases expression |
ISO |
Oligopeptides analog results in increased expression of ATG3 protein |
CTD |
PMID:24875536 |
|
NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224
|
|
G |
Atg5 |
autophagy related 5 |
increases expression |
ISO |
Oligopeptides analog results in increased expression of ATG5 protein |
CTD |
PMID:24875536 |
|
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
|
|
G |
Atg7 |
autophagy related 7 |
increases expression |
ISO |
Oligopeptides analog results in increased expression of ATG7 protein |
CTD |
PMID:24875536 |
|
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
Oligopeptides analog results in increased expression of BAX protein |
CTD |
PMID:24875536 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
Oligopeptides analog results in decreased expression of BCL2 protein |
CTD |
PMID:24875536 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Becn1 |
beclin 1 |
multiple interactions increases expression |
ISO |
BECN1 mutant form inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein] Oligopeptides analog results in increased expression of BECN1 protein |
CTD |
PMID:24875536 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases cleavage |
ISO EXP |
benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Oligopeptides analog results in increased cleavage of CASP3 protein] Oligopeptides inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] |
CTD |
PMID:24875536 PMID:25868679 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
Oligopeptides inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP9 protein] |
CTD |
PMID:25868679 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cat |
catalase |
multiple interactions |
ISO |
Oligopeptides inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of CAT protein] |
CTD |
PMID:22154906 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ctss |
cathepsin S |
decreases expression |
ISO |
Oligopeptides analog results in decreased expression of CTSS protein |
CTD |
PMID:24875536 |
|
NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
|
|
G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein] |
CTD |
PMID:22154906 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
|
|
G |
Gss |
glutathione synthetase |
increases activity |
ISO |
Oligopeptides results in increased activity of GSS protein |
CTD |
PMID:23796539 |
|
NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO |
Oligopeptides analog results in increased phosphorylation of MAPK1 protein U 0126 inhibits the reaction [Oligopeptides analog results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24875536 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
Oligopeptides analog results in increased phosphorylation of MAPK3 protein U 0126 inhibits the reaction [Oligopeptides analog results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24875536 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation |
ISO |
Oligopeptides analog results in decreased phosphorylation of MTOR protein |
CTD |
PMID:24875536 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Oligopeptides inhibits the reaction [Galactose results in increased activity of NOS2 protein]; Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] |
CTD |
PMID:22154906 PMID:23796539 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; BECN1 mutant form inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein] |
CTD |
PMID:24875536 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] |
CTD |
PMID:22154906 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases phosphorylation |
ISO |
Oligopeptides analog results in decreased phosphorylation of RPS6KB1 protein |
CTD |
PMID:24875536 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:22154906 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Bdkrb1 |
bradykinin receptor B1 |
increases expression multiple interactions |
ISO |
bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein lipopolysaccharide A promotes the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein]; Thalidomide inhibits the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein]; TNF protein promotes the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein]; TNFRSF1A protein promotes the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein] |
CTD |
PMID:16039549 |
|
NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
TNF protein promotes the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein] |
CTD |
PMID:16039549 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
multiple interactions |
ISO |
TNFRSF1A protein promotes the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein] |
CTD |
PMID:16039549 |
|
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
|
|
|
G |
Folh1 |
folate hydrolase 1 |
affects binding multiple interactions |
ISO |
isospaglumic acid binds to FOLH1 protein [2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein] |
CTD |
PMID:24508213 |
|
NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379
|
|
|
G |
Ace |
angiotensin I converting enzyme |
increases expression decreases expression multiple interactions |
ISO |
goralatide results in increased expression of ACE mRNA goralatide results in decreased expression of ACE mRNA [BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA] |
CTD |
PMID:20096676 PMID:33007385 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
|
|
G |
Ace2 |
angiotensin converting enzyme 2 |
multiple interactions |
ISO |
ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein] |
CTD |
PMID:33007385 |
|
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO EXP |
goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein] [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein] |
CTD |
PMID:31181250 PMID:33007385 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
|
|
G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]; goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of VIM protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SHH protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein] |
CTD |
PMID:31181250 PMID:33007385 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
ISO |
ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein] |
CTD |
PMID:33007385 |
|
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
|
|
G |
Bdkrb1 |
bradykinin receptor B1 |
multiple interactions affects abundance |
ISO |
[BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide BDKRB1 protein affects the abundance of goralatide |
CTD |
PMID:20096676 |
|
NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
|
|
G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] |
CTD |
PMID:33007385 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
|
|
G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein] |
CTD |
PMID:33007385 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
|
|
G |
Gli1 |
GLI family zinc finger 1 |
multiple interactions |
EXP ISO |
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI1 protein] |
CTD |
PMID:31181250 |
|
NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
|
|
G |
Gli2 |
GLI family zinc finger 2 |
multiple interactions |
EXP ISO |
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI2 protein] |
CTD |
PMID:31181250 |
|
NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
|
|
G |
Gli3 |
GLI family zinc finger 3 |
multiple interactions |
EXP ISO |
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of GLI3 protein] |
CTD |
PMID:31181250 |
|
NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
|
|
G |
Mas1 |
MAS1 proto-oncogene, G protein-coupled receptor |
multiple interactions |
ISO |
ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] |
CTD |
PMID:33007385 |
|
NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
|
|
G |
Ptch1 |
patched 1 |
multiple interactions |
EXP ISO |
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein] |
CTD |
PMID:31181250 |
|
NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
|
|
G |
Shh |
sonic hedgehog signaling molecule |
multiple interactions |
ISO EXP |
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SHH protein] [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein] |
CTD |
PMID:31181250 |
|
NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
|
|
G |
Smo |
smoothened, frizzled class receptor |
multiple interactions |
EXP ISO |
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein] |
CTD |
PMID:31181250 |
|
NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
|
|
G |
Vim |
vimentin |
multiple interactions |
ISO |
goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of VIM protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] |
CTD |
PMID:33007385 |
|
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
|
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
CTD |
PMID:15364539 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Apob |
apolipoprotein B |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Glucosamine results in decreased expression of and results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [lactacystin results in decreased expression of and results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal results in increased expression of and results in increased secretion of APOB protein |
CTD |
PMID:19342510 PMID:19383982 |
|
NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
|
|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of BIRC5 protein] |
CTD |
PMID:29974605 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
|
|
G |
Capn1 |
calpain 1 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in increased expression of CAPN1 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Acrylamide results in increased expression of CAPN1 protein] |
CTD |
PMID:35713544 PMID:37353096 |
|
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
|
|
G |
Capn2 |
calpain 2 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in increased expression of CAPN2 protein] |
CTD |
PMID:35713544 |
|
NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
|
|
G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal results in increased activity of CASP3 protein acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein] |
CTD |
PMID:15618349 PMID:27481217 PMID:29111403 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal promotes the reaction [Immunologic Factors results in increased expression of CASP7 protein modified form] |
CTD |
PMID:29974605 |
|
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
|
|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] |
CTD |
PMID:29111403 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
G |
Cast |
calpastatin |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in increased cleavage of CAST protein] |
CTD |
PMID:35713544 |
|
NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659
|
|
G |
Ccnb1 |
cyclin B1 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [arsenite results in increased degradation of CCNB1 protein] |
CTD |
PMID:17373649 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
|
|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [resveratrol results in increased degradation of CCND1 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Tretinoin results in increased degradation of and results in decreased expression of CCND1 protein] |
CTD |
PMID:11895924 PMID:16024653 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Ccnd3 |
cyclin D3 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Tretinoin results in increased degradation of and results in decreased expression of CCND3 protein] |
CTD |
PMID:16024653 |
|
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
|
|
G |
Cdc20 |
cell division cycle 20 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in increased degradation of CDC20 protein]; acetylleucyl-leucyl-norleucinal promotes the reaction [Cadmium Chloride results in increased ubiquitination of CDC20 protein] |
CTD |
PMID:20054826 |
|
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
|
|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of CTNNB1 protein] |
CTD |
PMID:29974605 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
|
|
G |
Dnm1l |
dynamin 1-like |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal affects the reaction [Acetaminophen affects the phosphorylation of DNM1L protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in increased expression of and results in increased cleavage of DNM1L protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein] |
CTD |
PMID:27481217 PMID:35713544 |
|
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
|
|
G |
Eif4e |
eukaryotic translation initiation factor 4E |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein] |
CTD |
PMID:15878868 |
|
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
|
|
G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA] |
CTD |
PMID:17559834 |
|
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in increased activity of GPT protein] |
CTD |
PMID:35713544 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Acrylamide results in decreased expression of HSPA9 protein] |
CTD |
PMID:37353096 |
|
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [IL1B protein results in increased ubiquitination of NFKBIA protein] |
CTD |
PMID:17291458 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Ins1 |
insulin 1 |
decreases secretion |
ISO EXP |
acetylleucyl-leucyl-norleucinal results in decreased secretion of INS1 protein |
CTD |
PMID:15618349 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
|
|
G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal promotes the reaction [Tretinoin results in increased expression of ITGAM protein] |
CTD |
PMID:20945414 |
|
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
|
|
G |
Itpr3 |
inositol 1,4,5-trisphosphate receptor, type 3 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Acrylamide results in decreased expression of ITPR3 protein] |
CTD |
PMID:37353096 |
|
NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases phosphorylation |
ISO |
acetylleucyl-leucyl-norleucinal results in increased phosphorylation of JUN protein |
CTD |
PMID:15618349 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation |
ISO |
acetylleucyl-leucyl-norleucinal results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:15618349 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mapk8ip1 |
mitogen-activated protein kinase 8 interacting protein 1 |
increases expression |
ISO EXP |
acetylleucyl-leucyl-norleucinal results in increased expression of MAPK8IP1 protein |
CTD |
PMID:15618349 |
|
NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
|
|
G |
Mfn2 |
mitofusin 2 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in decreased expression of and results in increased cleavage of MFN2 protein] |
CTD |
PMID:35713544 |
|
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of MYC protein] |
CTD |
PMID:29974605 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions decreases degradation |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid results in increased degradation of and results in decreased expression of NFKBIA protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [IL1B protein results in increased ubiquitination of NFKBIA protein] acetylleucyl-leucyl-norleucinal results in decreased degradation of NFKBIA protein |
CTD |
PMID:15930313 PMID:17291458 PMID:18606398 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] |
CTD |
PMID:29111403 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Ppp3ca |
protein phosphatase 3 catalytic subunit alpha |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Acetaminophen results in increased cleavage of PPP3CA protein] |
CTD |
PMID:35713544 |
|
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
|
|
G |
Rad51 |
RAD51 recombinase |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] |
CTD |
PMID:21810436 |
|
NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
|
|
G |
Rbpj |
recombination signal binding protein for immunoglobulin kappa J region |
increases expression |
ISO |
acetylleucyl-leucyl-norleucinal results in increased expression of RBPJ protein |
CTD |
PMID:22302987 |
|
NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
|
|
G |
Scnn1g |
sodium channel epithelial 1 subunit gamma |
increases methylation decreases expression |
ISO |
acetylleucyl-leucyl-norleucinal results in increased methylation of SCNN1G promoter acetylleucyl-leucyl-norleucinal results in decreased expression of SCNN1G mRNA |
CTD |
PMID:15564131 |
|
NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816
|
|
G |
Slc38a3 |
solute carrier family 38, member 3 |
multiple interactions |
EXP |
acetylleucyl-leucyl-norleucinal inhibits the reaction [manganese chloride results in increased degradation of SLC38A3 protein] |
CTD |
PMID:20737472 |
|
NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988
|
|
G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [SGA 360 results in increased degradation of and results in decreased expression of SREBF1 protein] |
CTD |
PMID:31225620 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
|
|
G |
Ttn |
titin |
multiple interactions |
EXP |
acetylleucyl-leucyl-norleucinal inhibits the reaction [Doxorubicin results in increased degradation of TTN protein] |
CTD |
PMID:22532871 |
|
NCBI chr 3:61,652,432...61,924,912
Ensembl chr 3:61,652,439...61,924,741
|
|
G |
Tymp |
thymidine phosphorylase |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMP protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]] |
CTD |
PMID:21444628 PMID:30796972 |
|
NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874 Ensembl chr 7:120,438,770...120,443,874
|
|
G |
Tyms |
thymidylate synthetase |
multiple interactions |
ISO |
acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein] |
CTD |
PMID:21444628 |
|
NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
|
|
|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
alanylglutamine inhibits the reaction [tcdA protein, Clostridium difficile results in increased activity of CASP8 protein] |
CTD |
PMID:16368960 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
arginyl-glycyl-aspartic acid inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:14627993 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Itga5 |
integrin subunit alpha 5 |
multiple interactions |
ISO |
arginyl-glycyl-aspartic acid inhibits the reaction [Resveratrol binds to [ITGA5 protein binds to ITGB3 protein]] |
CTD |
PMID:16790523 |
|
NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
|
|
G |
Itgav |
integrin subunit alpha V |
multiple interactions |
ISO |
arginyl-glycyl-aspartic acid inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]] |
CTD |
PMID:15213856 |
|
NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639
|
|
G |
Itgb1 |
integrin subunit beta 1 |
affects binding |
ISO |
arginyl-glycyl-aspartic acid binds to ITGB1 protein |
CTD |
PMID:37027338 |
|
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
|
|
G |
Itgb3 |
integrin subunit beta 3 |
multiple interactions |
ISO |
arginyl-glycyl-aspartic acid inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; arginyl-glycyl-aspartic acid inhibits the reaction [Resveratrol binds to [ITGA5 protein binds to ITGB3 protein]] |
CTD |
PMID:15213856 PMID:16790523 |
|
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO EXP |
arginyl-glycyl-aspartic acid inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK1 protein] arginyl-glycyl-aspartic acid inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; arginyl-glycyl-aspartic acid inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:14627993 PMID:16790523 PMID:17984113 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO EXP |
arginyl-glycyl-aspartic acid inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK3 protein] arginyl-glycyl-aspartic acid inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; arginyl-glycyl-aspartic acid inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:14627993 PMID:16790523 PMID:17984113 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mmp1 |
matrix metallopeptidase 1 |
increases expression |
ISO |
arginyl-glycyl-aspartic acid results in increased expression of MMP1 |
CTD |
PMID:15547672 |
|
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
|
|
G |
Myl9 |
myosin light chain 9 |
affects phosphorylation |
ISO |
arginyl-glycyl-aspartic acid affects the phosphorylation of MYL9 protein |
CTD |
PMID:37027338 |
|
NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
|
|
G |
Pou5f1 |
POU class 5 homeobox 1 |
decreases expression |
ISO |
arginyl-glycyl-aspartic acid results in decreased expression of POU5F1 protein |
CTD |
PMID:37027338 |
|
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
|
|
G |
Tfap2a |
transcription factor AP-2 alpha |
decreases expression |
ISO |
arginyl-glycyl-aspartic acid results in decreased expression of TFAP2A protein |
CTD |
PMID:37027338 |
|
NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507
|
|
G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
decreases expression |
ISO |
arginyl-glycyl-aspartic acid results in decreased expression of TIMP1 |
CTD |
PMID:15547672 |
|
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
arginyl-glycyl-aspartic acid inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein] |
CTD |
PMID:16790523 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
|
G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCA1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
|
|
G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCB4 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
|
|
G |
Abcd1 |
ATP binding cassette subfamily D member 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of ABCD1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr X:151,428,334...151,450,115
Ensembl chr X:151,428,578...151,450,115
|
|
G |
Abcd2 |
ATP binding cassette subfamily D member 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642
|
|
G |
Acaa1a |
acetyl-CoA acyltransferase 1A |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACAA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1A mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624
|
|
G |
Acaa1b |
acetyl-Coenzyme A acyltransferase 1B |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1B mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825
|
|
G |
Acacb |
acetyl-CoA carboxylase beta |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACACB mRNA |
CTD |
PMID:23783067 |
|
NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
|
|
G |
Acads |
acyl-CoA dehydrogenase short chain |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADS mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADS mRNA |
CTD |
PMID:23783067 |
|
NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
|
|
G |
Acadvl |
acyl-CoA dehydrogenase, very long chain |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADVL mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADVL mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
|
|
G |
Ache |
acetylcholinesterase |
decreases activity |
ISO EXP |
Aspartame metabolite results in decreased activity of ACHE protein |
CTD |
PMID:16129618 PMID:17580119 PMID:17673349 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
|
|
G |
Aco1 |
aconitase 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of ACO1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACO1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
|
|
G |
Acot1 |
acyl-CoA thioesterase 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACOT1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
|
|
G |
Adgre1 |
adhesion G protein-coupled receptor E1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ADGRE1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
|
|
G |
Agt |
angiotensinogen |
decreases expression |
ISO |
Aspartame results in decreased expression of AGT mRNA |
CTD |
PMID:31655124 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Agtr1a |
angiotensin II receptor, type 1a |
decreases expression |
ISO |
Aspartame results in decreased expression of AGTR1 mRNA |
CTD |
PMID:31655124 |
|
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation |
ISO |
Aspartame results in increased phosphorylation of AKT1 protein |
CTD |
PMID:33992720 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Alox15 |
arachidonate 15-lipoxygenase |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ALOX15 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
|
|
G |
Apoe |
apolipoprotein E |
decreases expression |
ISO |
Aspartame results in decreased expression of APOE mRNA |
CTD |
PMID:31655124 |
|
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
EXP ISO |
[Aspartame co-treated with Methotrexate] results in increased expression of BAX mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of BAX protein Aspartame results in increased expression of BAX mRNA [Fats, Unsaturated co-treated with Aspartame] affects the expression of BAX mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of BAX mRNA |
CTD |
PMID:23783067 PMID:25009784 PMID:32951320 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
EXP ISO |
[Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 mRNA; [Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 protein Aspartame results in decreased expression of BCL2 mRNA |
CTD |
PMID:25009784 PMID:32951320 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Cabp2 |
calcium binding protein 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CABP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CABP2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:201,374,649...201,380,469
Ensembl chr 1:201,375,276...201,380,469
|
|
G |
Cacna1a |
calcium voltage-gated channel subunit alpha1 A |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1A mRNA |
CTD |
PMID:23783067 |
|
NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
|
|
G |
Cacna1i |
calcium voltage-gated channel subunit alpha1 I |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1I mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1I mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
|
|
G |
Cacna2d4 |
calcium voltage-gated channel auxiliary subunit alpha2delta 4 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA2D4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA2D4 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:152,408,588...152,521,478
Ensembl chr 4:152,408,657...152,521,268
|
|
G |
Cacnb2 |
calcium voltage-gated channel auxiliary subunit beta 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNB2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
|
|
G |
Cacng4 |
calcium voltage-gated channel auxiliary subunit gamma 4 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG4 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:92,683,778...92,745,842
Ensembl chr10:92,683,761...92,746,126
|
|
G |
Cacng8 |
calcium voltage-gated channel auxiliary subunit gamma 8 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG8 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:65,755,334...65,775,567
Ensembl chr 1:65,755,334...65,779,089
|
|
G |
Calhm2 |
calcium homeostasis modulator family member 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CALHM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALHM2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:246,022,324...246,028,050
Ensembl chr 1:246,022,324...246,028,218
|
|
G |
Calr3 |
calreticulin 3 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CALR3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALR3 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr16:17,396,064...17,423,166
Ensembl chr16:17,396,247...17,423,015
|
|
G |
Cant1 |
calcium activated nucleotidase 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CANT1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CANT1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:103,637,079...103,650,240
Ensembl chr10:103,531,504...103,650,109
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases expression |
EXP ISO |
[Aspartame co-treated with Methotrexate] results in increased expression of CASP3 mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of CASP3 protein modified form Aspartame results in increased expression of CASP3 mRNA |
CTD |
PMID:25009784 PMID:32951320 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CASP9 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CASP9 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cat |
catalase |
multiple interactions decreases activity |
EXP ISO |
[Aspartame co-treated with Methotrexate] results in increased activity of CAT protein Aspartame results in decreased activity of CAT protein |
CTD |
PMID:25009784 PMID:32951320 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] results in increased expression of CCL2 protein; [Sodium Glutamate co-treated with Aspartame] inhibits the reaction [Fats, Unsaturated results in increased expression of CCL2 protein] |
CTD |
PMID:23783067 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Cdh1 |
cadherin 1 |
decreases expression |
ISO |
Aspartame results in decreased expression of CDH1 protein |
CTD |
PMID:33992720 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
affects localization multiple interactions |
ISO |
Aspartame affects the localization of CDKN1A protein TAS1R1 protein affects the reaction [Aspartame affects the localization of CDKN1A protein] |
CTD |
PMID:33992720 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions decreases expression |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CDKN1B mRNA Aspartame results in decreased expression of CDKN1B protein |
CTD |
PMID:23783067 PMID:33992720 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
|
|
G |
Cherp |
calcium homeostasis endoplasmic reticulum protein |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CHERP mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CHERP mRNA |
CTD |
PMID:23783067 |
|
NCBI chr16:17,367,455...17,380,507
Ensembl chr16:17,367,455...17,380,507
|
|
G |
Cmc1 |
C-x(9)-C motif containing 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CMC1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CMC1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 8:117,798,036...117,900,458
Ensembl chr 8:117,798,945...117,900,462
|
|
G |
Cox11 |
cytochrome c oxidase copper chaperone COX11 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of COX11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX11 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322
|
|
G |
Cox7a1 |
cytochrome c oxidase subunit 7A1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of COX7A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX7A1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:85,422,162...85,447,530
Ensembl chr 1:85,441,871...85,445,151
|
|
G |
Cpt1b |
carnitine palmitoyltransferase 1B |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of CPT1B mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1B mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
|
|
G |
Cpt1c |
carnitine palmitoyltransferase 1c |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1C mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342
|
|
G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CREB1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
|
|
G |
Csf1 |
colony stimulating factor 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CSF1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases activity |
EXP |
Aspartame results in increased activity of CYP1A1 protein |
CTD |
PMID:16937917 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases activity |
EXP |
Aspartame results in increased activity of CYP1A2 protein |
CTD |
PMID:16937917 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
multiple interactions |
EXP |
Aspartame results in increased expression of and results in increased activity of CYP2B1 protein |
CTD |
PMID:16937917 |
|
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
|
|
G |
Cyp2b2 |
cytochrome P450, family 2, subfamily b, polypeptide 2 |
increases activity |
EXP |
Aspartame results in increased activity of CYP2B2 protein |
CTD |
PMID:16937917 |
|
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
Aspartame results in increased expression of and results in increased activity of CYP2E1 protein |
CTD |
PMID:16937917 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
increases activity |
EXP |
Aspartame results in increased activity of CYP3A62 protein |
CTD |
PMID:16937917 |
|
NCBI chr12:16,397,998...16,433,833
Ensembl chr12:16,397,998...16,433,833
|
|
G |
Diablo |
diablo, IAP-binding mitochondrial protein |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of DIABLO mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DIABLO mRNA |
CTD |
PMID:23783067 |
|
NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
|
|
G |
Dnajc27 |
DnaJ heat shock protein family (Hsp40) member C27 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of DNAJC27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DNAJC27 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 6:27,068,713...27,098,449
Ensembl chr 6:27,068,686...27,098,449
|
|
G |
E2f1 |
E2F transcription factor 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of E2F1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of E2F1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
|
|
G |
Edn2 |
endothelin 2 |
decreases expression |
ISO |
Aspartame results in decreased expression of EDN2 mRNA |
CTD |
PMID:31655124 |
|
NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814
|
|
G |
Ednra |
endothelin receptor type A |
decreases expression |
ISO |
Aspartame results in decreased expression of EDNRA mRNA |
CTD |
PMID:31655124 |
|
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
|
|
G |
Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of EHHADH mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EHHADH mRNA |
CTD |
PMID:23783067 |
|
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
|
|
G |
Ephx2 |
epoxide hydrolase 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of EPHX2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EPHX2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
|
|
G |
F2 |
coagulation factor II, thrombin |
decreases activity |
ISO |
Aspartame analog results in decreased activity of F2 protein; Aspartame results in decreased activity of F2 protein |
CTD |
PMID:15572260 |
|
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
|
|
G |
Fgf1 |
fibroblast growth factor 1 |
increases expression |
ISO |
Aspartame results in increased expression of FGF1 mRNA |
CTD |
PMID:31655124 |
|
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
|
|
G |
Foxo3 |
forkhead box O3 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of FOXO3 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
|
|
G |
Fshb |
follicle stimulating hormone subunit beta |
decreases expression |
ISO |
Aspartame results in decreased expression of FSHB protein |
CTD |
PMID:32951320 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
|
|
G |
Gadd45b |
growth arrest and DNA-damage-inducible, beta |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GADD45B mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
|
|
G |
Gfm2 |
GTP dependent ribosome recycling factor mitochondrial 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of GFM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GFM2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:28,449,452...28,488,200
Ensembl chr 2:28,449,517...28,488,197
|
|
G |
Gip |
gastric inhibitory polypeptide |
multiple interactions |
ISO |
Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]; Sodium Glutamate inhibits the reaction [Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]] |
CTD |
PMID:23783067 |
|
NCBI chr10:80,968,360...80,976,506
Ensembl chr10:80,968,352...80,976,503
|
|
G |
Gli1 |
GLI family zinc finger 1 |
affects localization multiple interactions |
ISO |
Aspartame affects the localization of GLI1 protein TAS1R1 protein affects the reaction [Aspartame affects the localization of GLI1 protein] |
CTD |
PMID:33992720 |
|
NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
|
|
G |
Gli2 |
GLI family zinc finger 2 |
decreases expression |
ISO |
Aspartame results in decreased expression of GLI2 protein |
CTD |
PMID:33992720 |
|
NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
|
|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation |
ISO |
Aspartame results in increased phosphorylation of GSK3B protein |
CTD |
PMID:33992720 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
[Aspartame co-treated with Methotrexate] results in decreased activity of GSR protein |
CTD |
PMID:25009784 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHA mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
|
|
G |
Hadhb |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHB mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
|
|
G |
Hdac1 |
histone deacetylase 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
|
|
G |
Hdac5 |
histone deacetylase 5 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC5 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
|
|
G |
Hgf |
hepatocyte growth factor |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HGF mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
|
|
G |
Hras |
HRas proto-oncogene, GTPase |
increases expression |
ISO |
Aspartame results in increased expression of HRAS |
CTD |
PMID:17354619 |
|
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
|
|
G |
Hspg2 |
heparan sulfate proteoglycan 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HSPG2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594
|
|
G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of IDH2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IDH2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
|
|
G |
Il11 |
interleukin 11 |
decreases expression |
ISO |
Aspartame results in decreased expression of IL11 mRNA |
CTD |
PMID:31655124 |
|
NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
|
|
G |
Il1b |
interleukin 1 beta |
increases expression |
ISO |
Aspartame results in increased expression of IL1B mRNA |
CTD |
PMID:31655124 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il3 |
interleukin 3 |
decreases expression |
ISO |
Aspartame results in decreased expression of IL3 mRNA |
CTD |
PMID:31655124 |
|
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
|
|
G |
Il6 |
interleukin 6 |
increases secretion |
ISO |
Aspartame results in increased secretion of IL6 protein |
CTD |
PMID:20837131 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Immt |
inner membrane mitochondrial protein |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of IMMT mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IMMT mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109
|
|
G |
Ins2 |
insulin 2 |
increases expression multiple interactions |
ISO |
Aspartame results in increased expression of INS protein [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] results in increased expression of INS2 protein; Aspartame inhibits the reaction [Fats, Unsaturated results in increased expression of INS2 protein] |
CTD |
PMID:1805284 PMID:23783067 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
|
|
G |
Kdr |
kinase insert domain receptor |
increases secretion |
ISO |
Aspartame results in increased secretion of KDR protein |
CTD |
PMID:20837131 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
|
|
G |
Lep |
leptin |
decreases expression multiple interactions |
EXP ISO |
Aspartame results in decreased expression of LEP protein [Fats, Unsaturated co-treated with Aspartame] results in increased expression of LEP protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of LEP protein] |
CTD |
PMID:11890951 PMID:23783067 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
|
|
G |
Lhb |
luteinizing hormone subunit beta |
decreases expression |
ISO |
Aspartame results in decreased expression of LHB protein |
CTD |
PMID:32951320 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
|
|
G |
Lipg |
lipase G, endothelial type |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LIPG mRNA |
CTD |
PMID:23783067 |
|
NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
|
|
G |
Lrp1 |
LDL receptor related protein 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
|
|
G |
Lrp2 |
LDL receptor related protein 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708
|
|
G |
Lrp4 |
LDL receptor related protein 4 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP4 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
Aspartame results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:20837131 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
Aspartame results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:20837131 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mcu |
mitochondrial calcium uniporter |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MCU mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MCU mRNA |
CTD |
PMID:23783067 |
|
NCBI chr20:27,417,529...27,580,110
Ensembl chr20:27,417,526...27,580,110
|
|
G |
Mdm2 |
MDM2 proto-oncogene |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
|
|
G |
Med23 |
mediator complex subunit 23 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MED23 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:20,490,315...20,558,461
Ensembl chr 1:20,490,315...20,537,463
|
|
G |
Mef2d |
myocyte enhancer factor 2D |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MEF2D mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457
|
|
G |
Micos10 |
mitochondrial contact site and cristae organizing system subunit 10 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MINOS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MINOS1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:151,341,124...151,367,403
Ensembl chr 5:151,339,176...151,367,485
|
|
G |
Micu1 |
mitochondrial calcium uptake 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MICU1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MICU1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr20:27,668,681...27,816,322
Ensembl chr20:27,668,747...27,814,964
|
|
G |
Mrpl20 |
mitochondrial ribosomal protein L20 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL20 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL20 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:166,408,962...166,413,492
Ensembl chr 5:166,408,962...166,413,492
|
|
G |
Mrpl3 |
mitochondrial ribosomal protein L3 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL3 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 8:105,670,184...105,693,544
Ensembl chr 8:105,670,184...105,693,544
|
|
G |
Mrps12 |
mitochondrial ribosomal protein S12 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS12 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:84,025,896...84,028,896
Ensembl chr 1:84,025,899...84,028,780
|
|
G |
Mrps24 |
mitochondrial ribosomal protein S24 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS24 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS24 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr14:80,584,671...80,588,801
Ensembl chr14:80,584,673...80,588,871
|
|
G |
Mrps27 |
mitochondrial ribosomal protein S27 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS27 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:30,740,007...30,808,577
Ensembl chr 2:30,740,033...30,808,577
|
|
G |
Mrps7 |
mitochondrial ribosomal protein S7 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS7 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:100,843,691...100,846,838
Ensembl chr10:100,843,356...100,847,129
|
|
G |
Mtfp1 |
mitochondrial fission process 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of MTFP1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MTFP1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr14:78,968,434...78,972,274
Ensembl chr14:78,968,442...78,972,274
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
ISO |
Aspartame results in increased expression of MYC Aspartame results in increased expression of MYC protein |
CTD |
PMID:17354619 PMID:33992720 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
|
|
G |
Ncor1 |
nuclear receptor co-repressor 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NCOR1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
|
|
G |
Ndufa12 |
NADH:ubiquinone oxidoreductase subunit A12 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA12 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:28,771,330...28,798,316
Ensembl chr 7:28,771,330...28,798,315
|
|
G |
Ndufa5 |
NADH:ubiquinone oxidoreductase subunit A5 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA5 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598 Ensembl chr 5:52,995,546...53,005,598
|
|
G |
Ndufb10 |
NADH:ubiquinone oxidoreductase subunit B10 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB10 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB10 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442
|
|
G |
Ndufb2 |
NADH:ubiquinone oxidoreductase subunit B2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851 Ensembl chr 4:46,536,062...46,536,851
|
|
G |
Ndufb6 |
NADH:ubiquinone oxidoreductase subunit B6 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB6 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181
|
|
G |
Ndufs1 |
NADH:ubiquinone oxidoreductase core subunit S1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893
|
|
G |
Ndufs6 |
NADH:ubiquinone oxidoreductase subunit S6 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS6 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:29,968,833...29,977,423
Ensembl chr 1:29,968,842...29,977,467
|
|
G |
Ndufv1 |
NADH:ubiquinone oxidoreductase core subunit V1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFV1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFV1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466
|
|
G |
Nf1 |
neurofibromin 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NF1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
|
|
G |
Notch1 |
notch receptor 1 |
multiple interactions affects localization |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOTCH1 mRNA Aspartame affects the localization of NOTCH1 protein modified form TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form] |
CTD |
PMID:23783067 PMID:33992720 |
|
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
|
|
G |
Nox1 |
NADPH oxidase 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOX1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
|
|
G |
Nppb |
natriuretic peptide B |
decreases expression |
ISO |
Aspartame results in decreased expression of NPPB mRNA |
CTD |
PMID:31655124 |
|
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
|
|
G |
Npy |
neuropeptide Y |
decreases expression |
EXP |
Aspartame results in decreased expression of NPY protein |
CTD |
PMID:11890951 |
|
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
|
|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NR1I3 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
|
|
G |
Onecut1 |
one cut homeobox 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ONECUT1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277
|
|
G |
Pdha2 |
pyruvate dehydrogenase E1 subunit alpha 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHA2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHA2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:229,872,300...229,873,848
|
|
G |
Pdhb |
pyruvate dehydrogenase E1 subunit beta |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHB mRNA |
CTD |
PMID:23783067 |
|
NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500
|
|
G |
Pex1 |
peroxisomal biogenesis factor 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:30,519,950...30,558,953
Ensembl chr 4:30,519,955...30,558,921
|
|
G |
Pex11a |
peroxisomal biogenesis factor 11 alpha |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX11A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX11A mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:133,680,091...133,687,172
|
|
G |
Pex13 |
peroxisomal biogenesis factor 13 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX13 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr14:97,602,829...97,621,233
Ensembl chr14:97,603,539...97,621,262
|
|
G |
Pex5 |
peroxisomal biogenesis factor 5 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX5 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:157,270,671...157,296,432
Ensembl chr 4:157,270,672...157,296,431
|
|
G |
Pex7 |
peroxisomal biogenesis factor 7 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX7 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:14,582,698...14,646,686
Ensembl chr 1:14,582,699...14,646,748
|
|
G |
Pfkfb2 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699
|
|
G |
Pfkfb4 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB4 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634
|
|
G |
Pld2 |
phospholipase D2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLD2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
|
|
G |
Plg |
plasminogen |
decreases expression |
ISO |
Aspartame results in decreased expression of PLG mRNA |
CTD |
PMID:31655124 |
|
NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
|
|
G |
Plxnd1 |
plexin D1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLXND1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244
|
|
G |
Polg |
DNA polymerase gamma, catalytic subunit |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of POLG mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of POLG mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567
|
|
G |
Pomc |
proopiomelanocortin |
increases expression |
ISO |
Aspartame results in increased expression of POMC protein alternative form |
CTD |
PMID:1805284 |
|
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
|
|
G |
Pou5f1 |
POU class 5 homeobox 1 |
affects localization |
ISO |
Aspartame affects the localization of POU5F1 protein |
CTD |
PMID:33992720 |
|
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
|
|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARA mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
|
|
G |
Ppard |
peroxisome proliferator-activated receptor delta |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARD mRNA |
CTD |
PMID:23783067 |
|
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARG mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARGC1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARGC1A mRNA |
CTD |
PMID:23783067 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
|
|
G |
Prdx5 |
peroxiredoxin 5 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of PRDX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PRDX5 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268
|
|
G |
Rock1 |
Rho-associated coiled-coil containing protein kinase 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ROCK1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
|
|
G |
S100a13 |
S100 calcium binding protein A13 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A13 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:175,999,439...176,005,933
|
|
G |
S100a8 |
S100 calcium binding protein A8 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A8 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
|
|
G |
Sdhb |
succinate dehydrogenase complex iron sulfur subunit B |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of SDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SDHB mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
|
|
G |
Sirt1 |
sirtuin 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
|
|
G |
Sirt2 |
sirtuin 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
|
|
G |
Slc15a1 |
solute carrier family 15 member 1 |
decreases activity |
ISO |
Aspartame results in decreased activity of SLC15A1 protein |
CTD |
PMID:15846457 |
|
NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
|
|
G |
Slc4a2 |
solute carrier family 4 member 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC4A2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965
|
|
G |
Slc8a1 |
solute carrier family 8 member A1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of SLC8A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC8A1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
|
|
G |
Sox2 |
SRY-box transcription factor 2 |
affects localization |
ISO |
Aspartame affects the localization of SOX2 protein |
CTD |
PMID:33992720 |
|
NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338
|
|
G |
Srebf2 |
sterol regulatory element binding transcription factor 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SREBF2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of STAT3 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
G |
Surf1 |
SURF1, cytochrome c oxidase assembly factor |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of SURF1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SURF1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 3:10,241,793...10,244,686
Ensembl chr 3:10,241,837...10,263,315
|
|
G |
Tas1r1 |
taste 1 receptor member 1 |
increases expression multiple interactions |
ISO |
Aspartame results in increased expression of TAS1R1 protein Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of CDKN1A protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of GLI1 protein]; TAS1R1 protein affects the reaction [Aspartame affects the localization of NOTCH1 protein modified form] |
CTD |
PMID:33992720 |
|
NCBI chr 5:162,533,838...162,546,408
Ensembl chr 5:162,533,841...162,545,562
|
|
G |
Tas1r2 |
taste 1 receptor member 2 |
multiple interactions affects binding |
ISO |
Aspartame binds to and results in increased activity of TAS1R2 protein; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]] Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]; Aspartame binds to TAS1R2 protein |
CTD |
PMID:15353592 PMID:17168764 PMID:17935609 PMID:20173092 PMID:33992720 |
|
NCBI chr 5:151,909,617...151,925,760
Ensembl chr 5:151,830,701...151,925,345
|
|
G |
Tas1r3 |
taste 1 receptor member 3 |
affects binding decreases expression multiple interactions |
ISO |
Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein] Aspartame results in decreased expression of TAS1R3 protein Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]] |
CTD |
PMID:17168764 PMID:17935609 PMID:33992720 |
|
NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742
|
|
G |
Tfam |
transcription factor A, mitochondrial |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of TFAM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TFAM mRNA |
CTD |
PMID:23783067 |
|
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
|
|
G |
Thbs1 |
thrombospondin 1 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of THBS1 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] results in increased expression of TNF protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of TNF protein] |
CTD |
PMID:23783067 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tp53 |
tumor protein p53 |
increases expression multiple interactions |
ISO |
Aspartame results in increased expression of TRP53; Aspartame results in increased expression of TRP53 mRNA [Fats, Unsaturated co-treated with Aspartame] affects the expression of TRP53 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TRP53 mRNA |
CTD |
PMID:17354619 PMID:23783067 PMID:32951320 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
increases activity |
ISO |
Aspartame results in increased activity of TRPV1 protein |
CTD |
PMID:17567713 PMID:18804451 |
|
NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
|
|
G |
Tufm |
Tu translation elongation factor, mitochondrial |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of TUFM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TUFM mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
|
|
G |
Ucp2 |
uncoupling protein 2 |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of UCP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UCP2 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
|
|
G |
Uqcr11 |
ubiquinol-cytochrome c reductase, complex III subunit XI |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Aspartame] affects the expression of UQCR11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UQCR11 mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750
|
|
G |
Vegfa |
vascular endothelial growth factor A |
increases secretion |
ISO |
Aspartame results in increased secretion of VEGFA protein |
CTD |
PMID:20837131 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
G |
Vim |
vimentin |
increases expression |
ISO |
Aspartame results in increased expression of VIM protein |
CTD |
PMID:33992720 |
|
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
|
|
G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
ISO |
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of XDH mRNA |
CTD |
PMID:23783067 |
|
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
|
|
|
G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
atosiban inhibits the reaction [Sildenafil Citrate results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:27220266 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
|
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
decreases activity |
ISO |
B 581 results in decreased activity of NFKB1 protein |
CTD |
PMID:12085227 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
decreases phosphorylation |
ISO |
B 581 results in decreased phosphorylation of NFKBIA protein |
CTD |
PMID:12085227 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases activity |
ISO |
B 581 results in decreased activity of RELA protein |
CTD |
PMID:12085227 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
|
G |
Casp1 |
caspase 1 |
decreases activity multiple interactions |
ISO EXP |
belnacasan results in decreased activity of CASP1 protein belnacasan inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CASP1 protein] belnacasan inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein] |
CTD |
PMID:30205151 PMID:31070765 PMID:34935985 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
|
|
G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions |
EXP |
belnacasan inhibits the reaction [Clozapine results in increased secretion of CXCL1 protein] |
CTD |
PMID:34935985 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
|
|
G |
Il18 |
interleukin 18 |
multiple interactions |
ISO |
belnacasan inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein] belnacasan inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL18 protein] |
CTD |
PMID:30205151 PMID:31070765 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
belnacasan inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein] belnacasan inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein] belnacasan inhibits the reaction [Clozapine results in increased secretion of IL1B protein] |
CTD |
PMID:30205151 PMID:31070765 PMID:34935985 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
belnacasan inhibits the reaction [Clozapine results in increased secretion of TNF protein] |
CTD |
PMID:34935985 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Nos3 |
nitric oxide synthase 3 |
decreases expression |
ISO |
Bradykinin results in decreased expression of NOS3 mRNA |
CTD |
PMID:24839774 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
|
|
|
G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
[Buserelin co-treated with CGB3 protein] results in increased expression of ABCC3 mRNA |
CTD |
PMID:19955106 |
|
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
|
|
G |
Ahnak2 |
AHNAK nucleoprotein 2 |
multiple interactions |
ISO |
[Buserelin co-treated with CGB3 protein] results in increased expression of AHNAK2 mRNA |
CTD |
PMID:19955106 |
|
NCBI chr 6:131,830,668...131,876,311
Ensembl chr 6:131,831,454...131,854,463
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
Buserelin results in increased expression of BAX protein |
CTD |
PMID:15965100 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Casp3 |
caspase 3 |
increases expression |
ISO |
Buserelin results in increased expression of CASP3 protein |
CTD |
PMID:15965100 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
increases expression |
ISO |
Buserelin results in increased expression of CASP9 protein |
CTD |
PMID:15965100 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cycs |
cytochrome c, somatic |
affects localization |
ISO |
Buserelin affects the localization of CYCS protein |
CTD |
PMID:15965100 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
|
|
G |
Dkk1 |
dickkopf WNT signaling pathway inhibitor 1 |
multiple interactions |
ISO |
[Buserelin co-treated with CGB3 protein] results in increased expression of DKK1 mRNA; [Buserelin co-treated with CGB3 protein] results in increased expression of DKK1 protein |
CTD |
PMID:19955106 |
|
NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
|
|
G |
Dkk2 |
dickkopf WNT signaling pathway inhibitor 2 |
multiple interactions |
ISO |
[Buserelin co-treated with CGB3 protein] results in decreased expression of DKK2 mRNA |
CTD |
PMID:19955106 |
|
NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225
|
|
G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
Buserelin inhibits the reaction [Doxorubicin inhibits the reaction [FSHB protein results in increased chemical synthesis of Estradiol]] |
CTD |
PMID:17028438 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
|
|
G |
Gnrhr |
gonadotropin releasing hormone receptor |
multiple interactions |
ISO |
Buserelin binds to and results in increased activity of GNRHR protein; Buserelin inhibits the reaction [GNRHR protein results in increased transport of deslorelin] |
CTD |
PMID:15212170 |
|
NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
|
|
G |
Muc16 |
mucin 16, cell surface associated |
multiple interactions |
ISO |
[Buserelin co-treated with CGB3 protein] results in increased expression of MUC16 mRNA |
CTD |
PMID:19955106 |
|
NCBI chr 8:16,164,531...16,323,126
|
|
G |
Sfrp4 |
secreted frizzled-related protein 4 |
multiple interactions |
ISO |
[Buserelin co-treated with CGB3 protein] results in decreased expression of SFRP4 mRNA |
CTD |
PMID:19955106 |
|
NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736
|
|
|
G |
Afp |
alpha-fetoprotein |
multiple interactions |
EXP |
carfilzomib inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] |
CTD |
PMID:24632418 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
|
|
G |
Ar |
androgen receptor |
multiple interactions |
ISO |
carfilzomib inhibits the reaction [Metribolone results in increased activity of AR protein] |
CTD |
PMID:30818834 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
|
|
G |
Brca1 |
BRCA1, DNA repair associated |
increases response to substance |
ISO |
BRCA1 mutant form results in increased susceptibility to carfilzomib |
CTD |
PMID:25522274 |
|
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
|
|
G |
Brd4 |
bromodomain containing 4 |
multiple interactions |
ISO |
carfilzomib inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein] |
CTD |
PMID:26051217 |
|
NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
|
|
G |
Bsg |
basigin |
multiple interactions decreases expression |
ISO |
carfilzomib promotes the reaction [[Dronabinol co-treated with Cannabidiol] results in decreased expression of BSG mRNA] carfilzomib results in decreased expression of BSG mRNA |
CTD |
PMID:27769052 |
|
NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387
|
|
G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions increases activity |
ISO EXP |
carfilzomib results in increased cleavage of CASP3 protein apremilast inhibits the reaction [carfilzomib results in increased activity of CASP3 protein] |
CTD |
PMID:27769052 PMID:27785949 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cat |
catalase |
decreases activity |
EXP |
carfilzomib results in decreased activity of CAT protein |
CTD |
PMID:27785949 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ckm |
creatine kinase, M-type |
increases secretion multiple interactions |
EXP ISO |
carfilzomib results in increased secretion of CKM protein Dexrazoxane inhibits the reaction [carfilzomib results in increased secretion of CKM protein] apremilast inhibits the reaction [carfilzomib results in increased secretion of CKM protein] |
CTD |
PMID:26899300 PMID:27785949 |
|
NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
|
|
G |
Cox8a |
cytochrome c oxidase subunit 8A |
decreases expression |
ISO |
carfilzomib results in decreased expression of COX8A mRNA |
CTD |
PMID:30818834 |
|
NCBI chr 1:204,402,118...204,404,439
|
|
G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
decreases expression multiple interactions |
ISO |
carfilzomib results in decreased expression of CXCR4 mRNA carfilzomib promotes the reaction [[Dronabinol co-treated with Cannabidiol] results in decreased expression of CXCR4 mRNA] |
CTD |
PMID:27769052 |
|
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
|
|
G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
carfilzomib inhibits the reaction [Estradiol results in increased activity of ESR1 protein] |
CTD |
PMID:30818834 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
carfilzomib inhibits the reaction [Estradiol results in increased activity of ESR2 protein] |
CTD |
PMID:30818834 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
|
|
G |
Esrra |
estrogen related receptor, alpha |
multiple interactions |
ISO |
carfilzomib inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; carfilzomib inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] |
CTD |
PMID:30818834 |
|
NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
|
|
G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
increases secretion multiple interactions |
EXP |
carfilzomib results in increased secretion of GOT1 protein apremilast inhibits the reaction [carfilzomib results in increased secretion of GOT1 protein] |
CTD |
PMID:27785949 |
|
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
carfilzomib inhibits the reaction [Acetaminophen results in increased activity of GPT protein] |
CTD |
PMID:27900802 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Ldha |
lactate dehydrogenase A |
multiple interactions increases secretion |
EXP ISO |
apremilast inhibits the reaction [carfilzomib results in increased secretion of LDHA protein] Dexrazoxane inhibits the reaction [carfilzomib results in increased secretion of LDHA protein] |
CTD |
PMID:26899300 PMID:27785949 |
|
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
increases expression multiple interactions |
EXP |
carfilzomib results in increased expression of MAPK1 mRNA apremilast inhibits the reaction [carfilzomib results in increased expression of MAPK1 mRNA] |
CTD |
PMID:27785949 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases expression multiple interactions |
EXP |
carfilzomib results in increased expression of MAPK8 mRNA apremilast inhibits the reaction [carfilzomib results in increased expression of MAPK8 mRNA] |
CTD |
PMID:27785949 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
EXP |
carfilzomib inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein] |
CTD |
PMID:24632418 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
|
|
G |
Myh6 |
myosin heavy chain 6 |
multiple interactions decreases expression |
ISO |
Dexrazoxane inhibits the reaction [carfilzomib results in decreased expression of MYH6 mRNA] |
CTD |
PMID:26899300 |
|
NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
|
|
G |
Myh7 |
myosin heavy chain 7 |
increases expression multiple interactions |
ISO |
carfilzomib results in increased expression of MYH7 mRNA Dexrazoxane inhibits the reaction [carfilzomib results in increased expression of MYH7 mRNA] |
CTD |
PMID:26899300 |
|
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases activity |
ISO |
carfilzomib results in increased activity of NFE2L2 protein |
CTD |
PMID:30818834 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions decreases expression |
EXP |
apremilast inhibits the reaction [carfilzomib results in decreased expression of NFKBIA protein] |
CTD |
PMID:27785949 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
carfilzomib inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA] |
CTD |
PMID:27900802 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Pgr |
progesterone receptor |
multiple interactions |
ISO |
carfilzomib inhibits the reaction [Promegestone results in increased activity of PGR protein] |
CTD |
PMID:30818834 |
|
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
|
|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
ISO |
carfilzomib inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein] |
CTD |
PMID:30818834 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
|
|
G |
Prkcsh |
PRKCSH beta subunit of glucosidase II |
increases response to substance |
ISO |
PRKCSH gene mutant form results in increased susceptibility to carfilzomib |
CTD |
PMID:21685914 |
|
NCBI chr 8:20,534,787...20,546,493
Ensembl chr 8:20,534,880...20,546,492
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
carfilzomib inhibits the reaction [Acetaminophen results in increased expression of PTGS2 mRNA] |
CTD |
PMID:27900802 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
increases expression multiple interactions |
EXP |
carfilzomib results in increased expression of RELA mRNA apremilast inhibits the reaction [carfilzomib results in increased expression of RELA mRNA] |
CTD |
PMID:27785949 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases activity |
ISO |
carfilzomib results in decreased activity of TGFB1 protein |
CTD |
PMID:31652400 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
EXP |
carfilzomib inhibits the reaction [Diethylnitrosamine results in increased expression of TIMP1 protein] |
CTD |
PMID:24632418 |
|
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
carfilzomib inhibits the reaction [Acetaminophen results in increased expression of TNF protein] |
CTD |
PMID:27900802 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tp53 |
tumor protein p53 |
increases activity affects activity |
ISO |
carfilzomib results in increased activity of TP53 protein carfilzomib affects the activity of TP53 protein |
CTD |
PMID:30818834 PMID:35435491 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Zfand2a |
zinc finger AN1-type containing 2A |
increases expression |
ISO |
carfilzomib results in increased expression of ZFAND2A protein |
CTD |
PMID:31540997 |
|
NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677
|
|
|
G |
Ache |
acetylcholinesterase |
multiple interactions |
ISO |
Carnosine inhibits the reaction [cupric chloride results in decreased activity of ACHE protein] |
CTD |
PMID:32745495 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
Carnosine inhibits the reaction [Norepinephrine results in increased expression of ACTA2 mRNA] |
CTD |
PMID:34609854 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
|
|
G |
Ager |
advanced glycosylation end product-specific receptor |
multiple interactions |
ISO |
Carnosine inhibits the reaction [ALB protein modified form results in increased expression of AGER mRNA]; Carnosine inhibits the reaction [ALB protein modified form results in increased expression of AGER protein] |
CTD |
PMID:34609854 |
|
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of AKT1 protein] |
CTD |
PMID:28266762 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Alb |
albumin |
multiple interactions |
ISO |
Carnosine inhibits the reaction [ALB protein modified form results in increased expression of AGER mRNA]; Carnosine inhibits the reaction [ALB protein modified form results in increased expression of AGER protein]; Carnosine inhibits the reaction [ALB protein modified form results in increased expression of COL3A1 mRNA]; Carnosine inhibits the reaction [ALB protein modified form results in increased expression of TNF mRNA] |
CTD |
PMID:34609854 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
|
|
G |
App |
amyloid beta precursor protein |
decreases expression |
ISO |
Carnosine results in decreased expression of APP protein modified form |
CTD |
PMID:21423579 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP ISO |
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein] [Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Glucose results in increased expression of BAX mRNA] |
CTD |
PMID:28266762 PMID:28833918 PMID:30802477 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP ISO |
Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein] asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]; Carnosine inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]] |
CTD |
PMID:28266762 PMID:30802477 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Bmal1 |
basic helix-loop-helix ARNT like 1 |
increases abundance |
ISO |
BMAL1 gene mutant form results in increased abundance of Carnosine |
CTD |
PMID:27056296 |
|
NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
|
|
G |
Carns1 |
carnosine synthase 1 |
increases expression |
ISO EXP |
Carnosine results in increased expression of CARNS1 mRNA; Carnosine results in increased expression of CARNS1 protein |
CTD |
PMID:30485136 |
|
NCBI chr 1:201,459,061...201,470,019
Ensembl chr 1:201,459,076...201,469,845
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
Carnosine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein] [Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased activity of CASP3 protein]; Carnosine inhibits the reaction [Glucose results in increased activity of CASP3 protein] Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of CASP3 protein] |
CTD |
PMID:19748544 PMID:28833918 PMID:29191451 PMID:30802477 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
Carnosine inhibits the reaction [Cisplatin results in increased cleavage of CASP8 protein] |
CTD |
PMID:29191451 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
G |
Cat |
catalase |
multiple interactions |
ISO |
Carnosine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Carnosine inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Carnosine inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA] Carnosine inhibits the reaction [cupric chloride results in decreased activity of CAT protein] |
CTD |
PMID:19748544 PMID:19799668 PMID:29191451 PMID:32745495 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Carnosine inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of CCL2 protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of CCL2 mRNA] |
CTD |
PMID:19799668 PMID:29191451 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Cndp1 |
carnosine dipeptidase 1 |
increases expression |
EXP ISO |
Carnosine results in increased expression of CNDP1 mRNA; Carnosine results in increased expression of CNDP1 protein |
CTD |
PMID:30485136 |
|
NCBI chr18:77,984,886...78,030,837
Ensembl chr18:77,984,907...78,007,765
|
|
G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
Carnosine inhibits the reaction [ALB protein modified form results in increased expression of COL3A1 mRNA]; Carnosine inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA] |
CTD |
PMID:34609854 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
|
|
G |
Crp |
C-reactive protein |
multiple interactions |
ISO EXP |
Carnosine inhibits the reaction [Acetaminophen results in increased expression of CRP protein] Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of CRP protein] |
CTD |
PMID:19799668 PMID:28266762 PMID:28833918 |
|
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO |
Carnosine inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein] |
CTD |
PMID:19799668 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Carnosine results in increased expression of FOS protein |
CTD |
PMID:17628717 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
ISO |
Carnosine inhibits the reaction [cupric chloride results in decreased activity of G6PD protein] |
CTD |
PMID:32745495 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of GPT protein] |
CTD |
PMID:28833918 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO |
Carnosine inhibits the reaction [Acetaminophen results in decreased expression of GPX1 mRNA] |
CTD |
PMID:19799668 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
Carnosine inhibits the reaction [cupric chloride results in decreased activity of GSR protein] |
CTD |
PMID:32745495 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
EXP |
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein] |
CTD |
PMID:28266762 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
|
|
G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
increases expression |
EXP |
Carnosine results in increased expression of HSPA1B protein |
CTD |
PMID:16984587 |
|
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
Carnosine inhibits the reaction [Cisplatin results in increased expression of ICAM1 mRNA] |
CTD |
PMID:29191451 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
Carnosine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] |
CTD |
PMID:23011206 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
Carnosine inhibits the reaction [Acetaminophen results in increased expression of IL10 protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of IL10 mRNA] |
CTD |
PMID:19799668 PMID:29191451 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein]]; Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein] [Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL1B protein]; Carnosine inhibits the reaction [Glucose results in increased secretion of IL1B protein] |
CTD |
PMID:30802477 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]; Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]] [Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL6 protein]; Carnosine inhibits the reaction [Glucose results in increased secretion of IL6 protein] Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of IL6 protein] |
CTD |
PMID:19799668 PMID:28266762 PMID:30802477 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Ins1 |
insulin 1 |
multiple interactions |
ISO |
[Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Carnosine inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] |
CTD |
PMID:30802477 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
[Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; Carnosine inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:30802477 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
Carnosine inhibits the reaction [Cadmium Chloride results in increased activity of MPO protein] |
CTD |
PMID:19748544 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
EXP |
Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of NFKBIA mRNA] |
CTD |
PMID:28833918 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Carnosine inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] |
CTD |
PMID:29191451 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
Carnosine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] |
CTD |
PMID:23011206 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]]; Carnosine inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]] |
CTD |
PMID:30802477 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Carnosine inhibits the reaction [Cisplatin affects the localization of RELA protein]; Carnosine inhibits the reaction [Streptozocin results in increased expression of RELA protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]] |
CTD |
PMID:29191451 PMID:30802477 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Slc15a2 |
solute carrier family 15 member 2 |
increases expression |
ISO |
Carnosine results in increased expression of SLC15A2 mRNA; Carnosine results in increased expression of SLC15A2 protein |
CTD |
PMID:30485136 |
|
NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
|
|
G |
Slc15a4 |
solute carrier family 15 member 4 |
increases expression |
EXP |
Carnosine results in increased expression of SLC15A4 mRNA |
CTD |
PMID:30485136 |
|
NCBI chr12:29,048,634...29,082,480
Ensembl chr12:29,063,015...29,082,480
|
|
G |
Slc31a1 |
solute carrier family 31 member 1 |
decreases expression |
EXP ISO |
Carnosine results in decreased expression of SLC31A1 mRNA; Carnosine results in decreased expression of SLC31A1 protein |
CTD |
PMID:30485136 |
|
NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
|
|
G |
Smad2 |
SMAD family member 2 |
multiple interactions |
EXP |
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein] |
CTD |
PMID:28266762 |
|
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
Carnosine inhibits the reaction [cupric chloride results in decreased activity of SOD1 protein] |
CTD |
PMID:32745495 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G |
Sp1 |
Sp1 transcription factor |
decreases expression |
EXP ISO |
Carnosine results in decreased expression of SP1 mRNA |
CTD |
PMID:30485136 |
|
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
Carnosine inhibits the reaction [Norepinephrine results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:34609854 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein] |
CTD |
PMID:28266762 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; Carnosine inhibits the reaction [ALB protein modified form results in increased expression of TNF mRNA]; Carnosine inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; Carnosine inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]] asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]]; Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]] Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein] |
CTD |
PMID:19799668 PMID:28266762 PMID:29191451 PMID:30802477 PMID:34609854 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
EXP |
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of VEGFA protein] |
CTD |
PMID:28266762 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions increases expression |
ISO |
PTHLH protein promotes the reaction [Ceruletide results in increased expression of ACTA2 protein]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of ACTA2 mRNA]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of ACTA2 protein] Ceruletide results in increased expression of ACTA2 mRNA; Ceruletide results in increased expression of ACTA2 protein |
CTD |
PMID:25035110 PMID:38113986 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
|
|
G |
Ahcy |
adenosylhomocysteinase |
decreases expression |
EXP |
Ceruletide results in decreased expression of AHCY protein |
CTD |
PMID:18024178 |
|
NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
|
|
G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases expression |
EXP |
Ceruletide results in increased expression of AKR1B1 protein |
CTD |
PMID:18024178 |
|
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein |
CTD |
PMID:26390243 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Alb |
albumin |
decreases expression |
EXP |
Ceruletide results in decreased expression of ALB protein modified form |
CTD |
PMID:17169977 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
|
|
G |
Atf4 |
activating transcription factor 4 |
multiple interactions |
ISO |
[2,2',4,4'-tetrabromodiphenyl ether co-treated with Ceruletide] results in increased expression of ATF4 protein |
CTD |
PMID:38407484 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression multiple interactions |
ISO |
Ceruletide results in increased expression of BCL2 mRNA; Ceruletide results in increased expression of BCL2 protein coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 mRNA]; limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of BCL2 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of BCL2 protein] |
CTD |
PMID:34423886 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Bdkrb1 |
bradykinin receptor B1 |
increases expression |
ISO |
Ceruletide results in increased expression of BDKRB1 mRNA |
CTD |
PMID:21484880 |
|
NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
|
|
G |
Bdkrb2 |
bradykinin receptor B2 |
increases expression |
ISO |
Ceruletide results in increased expression of BDKRB2 mRNA |
CTD |
PMID:21484880 |
|
NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
|
|
G |
Brd4 |
bromodomain containing 4 |
multiple interactions |
ISO |
(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein |
CTD |
PMID:26390243 |
|
NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
[Glycodeoxycholic Acid co-treated with Ceruletide] results in decreased activity of CASP3 protein; Ceruletide results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:16339139 PMID:18832452 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp8 |
caspase 8 |
multiple interactions |
EXP |
Ceruletide results in increased cleavage of and results in increased activity of CASP8 protein |
CTD |
PMID:16339139 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
Ceruletide results in increased cleavage of and results in increased activity of CASP9 protein |
CTD |
PMID:16339139 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases secretion increases expression |
ISO |
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]]; limonin inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]; PPARG affects the reaction [Ceruletide results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]; Rosiglitazone inhibits the reaction [Ceruletide results in increased expression of CCL2 mRNA] |
CTD |
PMID:17463185 PMID:21484880 PMID:34423886 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Ccnd1 |
cyclin D1 |
multiple interactions increases expression |
ISO |
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 mRNA]; limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of CCND1 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of CCND1 protein] Ceruletide results in increased expression of CCND1 mRNA; Ceruletide results in increased expression of CCND1 protein |
CTD |
PMID:34423886 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Cct2 |
chaperonin containing TCP1 subunit 2 |
increases expression |
EXP |
Ceruletide results in increased expression of CCT2 protein |
CTD |
PMID:18024178 |
|
NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944
|
|
G |
Cebpa |
CCAAT/enhancer binding protein alpha |
increases expression multiple interactions |
EXP |
Ceruletide results in increased expression of CEBPA mRNA [Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPA protein; Dietary Fats promotes the reaction [Ceruletide results in increased expression of CEBPA mRNA]; Quercetin inhibits the reaction [[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPA protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of CEBPA mRNA] |
CTD |
PMID:26873426 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
|
|
G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions increases expression |
EXP |
[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPB protein; Dietary Fats promotes the reaction [Ceruletide results in increased expression of CEBPB mRNA]; Quercetin inhibits the reaction [[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPB protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of CEBPB mRNA] |
CTD |
PMID:26873426 |
|
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions increases expression |
ISO EXP |
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA] PTHLH protein inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA] |
CTD |
PMID:22280800 PMID:25035110 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
|
|
G |
Ctsb |
cathepsin B |
affects localization multiple interactions |
EXP |
Ceruletide affects the localization of CTSB protein sodium arsenite inhibits the reaction [Ceruletide affects the localization of CTSB protein] |
CTD |
PMID:17941083 |
|
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
|
|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases expression multiple interactions |
ISO |
Ceruletide results in increased expression of CXCL1 mRNA AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; AM 251 promotes the reaction [iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; HU 211 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; iodopravadoline promotes the reaction [AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; PPARG affects the reaction [Ceruletide results in increased expression of CXCL1 mRNA] |
CTD |
PMID:17463185 PMID:17484889 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
|
|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
[2,2',4,4'-tetrabromodiphenyl ether co-treated with Ceruletide] results in increased expression of DDIT3 protein |
CTD |
PMID:38407484 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
|
|
G |
Dusp1 |
dual specificity phosphatase 1 |
increases expression |
EXP |
Ceruletide results in increased expression of DUSP1 mRNA |
CTD |
PMID:11027531 |
|
NCBI chr10:16,680,478...16,683,275
|
|
G |
Dusp10 |
dual specificity phosphatase 10 |
increases expression |
EXP |
Ceruletide results in increased expression of DUSP10 mRNA |
CTD |
PMID:11027531 |
|
NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
|
|
G |
Dusp6 |
dual specificity phosphatase 6 |
increases expression |
EXP |
Ceruletide results in increased expression of DUSP6 mRNA |
CTD |
PMID:11027531 |
|
NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
|
|
G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
[2,2',4,4'-tetrabromodiphenyl ether co-treated with Ceruletide] results in increased expression of and results in increased phosphorylation of EIF2AK3 protein |
CTD |
PMID:38407484 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
|
|
G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
increases expression multiple interactions |
EXP |
Ceruletide results in increased expression of ERN1 mRNA; Ceruletide results in increased expression of ERN1 protein Dietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 mRNA]; Quercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 protein] |
CTD |
PMID:26873426 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
|
|
G |
Glud1 |
glutamate dehydrogenase 1 |
increases expression |
EXP |
Ceruletide results in increased expression of GLUD1 protein |
CTD |
PMID:18024178 |
|
NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions increases expression |
ISO |
isoborneol inhibits the reaction [Ceruletide results in increased expression of GPT protein] |
CTD |
PMID:33166053 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO |
Ceruletide results in increased expression of HMOX1 protein coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein] |
CTD |
PMID:34423886 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hnrnph1 |
heterogeneous nuclear ribonucleoprotein H1 |
increases expression |
EXP |
Ceruletide results in increased expression of HNRNPH1 protein |
CTD |
PMID:18024178 |
|
NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846
|
|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
decreases expression |
EXP |
Ceruletide results in decreased expression of HSPA5 protein |
CTD |
PMID:18024178 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
|
|
G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
decreases expression |
EXP |
Ceruletide results in decreased expression of HSPA8 protein |
CTD |
PMID:18024178 |
|
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
|
|
G |
Hyou1 |
hypoxia up-regulated 1 |
increases expression |
EXP |
Ceruletide results in increased expression of HYOU1 protein |
CTD |
PMID:18024178 |
|
NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions increases expression |
ISO |
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA] rosiglitazone inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA] |
CTD |
PMID:17463185 PMID:25035110 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Il10 |
interleukin 10 |
multiple interactions |
EXP |
[resveratrol co-treated with Ceruletide] results in increased expression of IL10 protein |
CTD |
PMID:24234420 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
|
|
G |
Il1b |
interleukin 1 beta |
increases expression increases secretion multiple interactions |
EXP ISO |
Ceruletide results in increased expression of IL1B mRNA; Ceruletide results in increased expression of IL1B protein Ceruletide results in increased secretion of IL1B protein coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]]; isoborneol inhibits the reaction [Ceruletide results in increased expression of IL1B protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of IL1B protein] Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL1B mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of IL1B protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of IL1B mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL1B mRNA]]; resveratrol inhibits the reaction [Ceruletide results in increased expression of IL1B protein] |
CTD |
PMID:14751415 PMID:21484880 PMID:24234420 PMID:26873426 PMID:33166053 PMID:34423886 More...
|
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
increases expression increases secretion multiple interactions |
ISO EXP |
Ceruletide results in increased expression of IL6 mRNA Ceruletide results in increased secretion of IL6 protein Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of IL6 protein]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]] (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]]; HU 211 inhibits the reaction [Ceruletide results in increased expression of IL6 protein]; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]]; isoborneol inhibits the reaction [Ceruletide results in increased expression of IL6 protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of IL6 protein] Ceruletide results in increased expression of IL6 mRNA; Ceruletide results in increased expression of IL6 protein PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA] |
CTD |
PMID:17484889 PMID:22280800 PMID:25035110 PMID:26390243 PMID:26873426 PMID:33166053 PMID:34423886 PMID:38113986 More...
|
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Jak2 |
Janus kinase 2 |
multiple interactions increases expression |
ISO |
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of JAK2 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of JAK2 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of JAK2 protein] |
CTD |
PMID:34423886 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
ISO |
Ceruletide results in increased expression of JUN mRNA rosiglitazone inhibits the reaction [Ceruletide results in increased expression of JUN mRNA] |
CTD |
PMID:17463185 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Kras |
KRAS proto-oncogene, GTPase |
multiple interactions |
ISO |
(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]] |
CTD |
PMID:26390243 |
|
NCBI chr 4:178,185,418...178,218,484
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
[2,2',4,4'-tetrabromodiphenyl ether co-treated with Ceruletide] results in increased expression of and results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:38407484 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mir216a |
microRNA 216a |
increases expression |
EXP |
Ceruletide results in increased expression of MIR216A mRNA |
CTD |
PMID:27521901 |
|
NCBI chr14:102,524,105...102,524,210
Ensembl chr14:102,524,105...102,524,210
|
|
G |
Mir216b |
microRNA 216b |
increases expression |
EXP |
Ceruletide results in increased expression of MIR216B mRNA |
CTD |
PMID:27521901 |
|
NCBI chr14:102,513,054...102,513,155
Ensembl chr14:102,513,054...102,513,155
|
|
G |
Mir217 |
microRNA 217 |
increases expression |
EXP |
Ceruletide results in increased expression of MIR217 mRNA |
CTD |
PMID:27521901 |
|
NCBI chr14:102,531,505...102,531,609
Ensembl chr14:102,531,505...102,531,609
|
|
G |
Mpo |
myeloperoxidase |
increases expression increases activity multiple interactions |
ISO |
Ceruletide results in increased expression of MPO protein Ceruletide results in increased activity of MPO protein HU 211 inhibits the reaction [Ceruletide results in increased expression of MPO protein]; isoborneol inhibits the reaction [Ceruletide results in increased activity of MPO protein] |
CTD |
PMID:17484889 PMID:33166053 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions decreases expression |
ISO |
isoborneol inhibits the reaction [Ceruletide results in decreased expression of NFE2L2 protein] |
CTD |
PMID:33166053 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
increases degradation multiple interactions |
EXP |
Ceruletide results in increased degradation of NFKBIA protein sodium arsenite inhibits the reaction [Ceruletide results in increased degradation of NFKBIA protein] |
CTD |
PMID:17941083 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nos2 |
nitric oxide synthase 2 |
increases expression multiple interactions |
ISO |
Ceruletide results in increased expression of NOS2 protein isoborneol inhibits the reaction [Ceruletide results in increased expression of NOS2 protein] |
CTD |
PMID:33166053 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Pdia4 |
protein disulfide isomerase family A, member 4 |
increases expression |
EXP |
Ceruletide results in increased expression of PDIA4 protein |
CTD |
PMID:18024178 |
|
NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
PPARG affects the reaction [Ceruletide results in increased expression of CCL2 mRNA]; PPARG affects the reaction [Ceruletide results in increased expression of CXCL1 mRNA] |
CTD |
PMID:17463185 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G |
Prdx2 |
peroxiredoxin 2 |
increases expression |
EXP |
Ceruletide results in increased expression of PRDX2 protein |
CTD |
PMID:18024178 |
|
NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression |
EXP |
Ceruletide results in increased expression of PTGS2 mRNA; Ceruletide results in increased expression of PTGS2 protein |
CTD |
PMID:14751415 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Pthlh |
parathyroid hormone-like hormone |
multiple interactions affects response to substance increases expression |
ISO EXP |
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]; PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA] Ethanol results in increased susceptibility to [Ceruletide results in increased expression of PTHLH mRNA]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA] PTHLH protein affects the susceptibility to Ceruletide Ceruletide results in increased expression of PTHLH mRNA; Ceruletide results in increased expression of PTHLH protein PTHLH protein promotes the reaction [Ceruletide results in increased expression of ACTA2 protein]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA] |
CTD |
PMID:22280800 PMID:25035110 |
|
NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases phosphorylation increases expression |
ISO |
ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate inhibits the reaction [Ceruletide results in increased expression of RELA protein]; isoborneol inhibits the reaction [Ceruletide results in decreased phosphorylation of RELA protein] |
CTD |
PMID:22982818 PMID:33166053 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Ripk1 |
receptor interacting serine/threonine kinase 1 |
increases cleavage |
EXP |
Ceruletide results in increased cleavage of RIPK1 protein |
CTD |
PMID:16339139 |
|
NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
|
|
G |
Ruvbl1 |
RuvB-like AAA ATPase 1 |
increases expression |
EXP |
Ceruletide results in increased expression of RUVBL1 protein |
CTD |
PMID:18024178 |
|
NCBI chr 4:120,932,486...120,967,400
Ensembl chr 4:120,932,417...121,029,384
|
|
G |
Serpinf1 |
serpin family F member 1 |
increases activity |
EXP |
cerulein increases activity of Serpinf1 protein in blood |
RGD |
PMID:10423332 |
RGD:1625538 |
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
|
|
G |
Smad2 |
SMAD family member 2 |
multiple interactions |
ISO |
[Shuangshen co-treated with Ceruletide] results in decreased expression of SMAD2 protein |
CTD |
PMID:38113986 |
|
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
|
|
G |
Smad3 |
SMAD family member 3 |
increases expression multiple interactions |
ISO |
Ceruletide results in increased expression of SMAD3 protein Shuangshen inhibits the reaction [Ceruletide results in increased expression of SMAD3 protein] |
CTD |
PMID:38113986 |
|
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions decreases expression |
ISO |
isoborneol inhibits the reaction [Ceruletide results in decreased expression of SOD1 protein] |
CTD |
PMID:33166053 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions increases phosphorylation |
ISO |
(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein]]; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]]; limonin inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:26390243 PMID:34423886 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions increases expression |
ISO |
Shuangshen inhibits the reaction [Ceruletide results in increased expression of TGFB1 protein] |
CTD |
PMID:38113986 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tnf |
tumor necrosis factor |
increases expression increases secretion multiple interactions |
EXP ISO |
Ceruletide results in increased expression of TNF mRNA; Ceruletide results in increased expression of TNF protein Ceruletide results in increased secretion of TNF protein coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of TNF protein]]; isoborneol inhibits the reaction [Ceruletide results in increased expression of TNF protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of TNF protein]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of TNF protein]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of TNF protein] 2-acetoxy-5-(2-4-(trifluoromethyl)phenethylamino)benzoic acid inhibits the reaction [[Ceruletide co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; [Ceruletide co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; arsenic trioxide inhibits the reaction [Ceruletide results in increased expression of TNF mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of TNF mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of TNF protein]; Pentoxifylline inhibits the reaction [Ceruletide results in increased expression of TNF protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of TNF mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of TNF mRNA]] |
CTD |
PMID:10773043 PMID:17517186 PMID:22575522 PMID:26873426 PMID:33166053 PMID:34423886 PMID:38113986 More...
|
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tpi1 |
triosephosphate isomerase 1 |
increases expression |
EXP |
Ceruletide results in increased expression of TPI1 protein |
CTD |
PMID:18024178 |
|
NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
|
|
G |
Vcp |
valosin-containing protein |
decreases expression |
EXP |
Ceruletide results in decreased expression of VCP protein |
CTD |
PMID:18024178 |
|
NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
|
|
G |
Xbp1 |
X-box binding protein 1 |
increases expression multiple interactions |
EXP |
Ceruletide results in increased expression of XBP1 mRNA alternative form; Ceruletide results in increased expression of XBP1 protein alternative form Dietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 protein alternative form]; Quercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]; Quercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 protein alternative form] |
CTD |
PMID:26873426 |
|
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
|
|
G |
Xiap |
X-linked inhibitor of apoptosis |
increases degradation |
EXP |
Ceruletide results in increased degradation of XIAP protein |
CTD |
PMID:16339139 |
|
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
|
|
|
G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases activity |
ISO |
cetrorelix results in decreased activity of ABCB11 protein |
CTD |
PMID:23956101 |
|
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
|
|
G |
Apoe |
apolipoprotein E |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of APOE mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of APOE mRNA |
CTD |
PMID:18160741 |
|
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO EXP |
cetrorelix results in increased expression of BAX mRNA; cetrorelix results in increased expression of BAX protein |
CTD |
PMID:17268770 PMID:18829022 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO EXP |
cetrorelix results in decreased expression of BCL2 protein cetrorelix results in decreased expression of BCL2 mRNA |
CTD |
PMID:18829022 PMID:21062912 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
cetrorelix results in decreased expression of BCL2L1 protein |
CTD |
PMID:21062912 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
|
|
G |
Casp3 |
caspase 3 |
increases activity |
ISO EXP |
cetrorelix results in increased activity of CASP3 protein |
CTD |
PMID:17268770 PMID:21062912 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
increases activity |
ISO EXP |
cetrorelix results in increased activity of CASP9 protein |
CTD |
PMID:17268770 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Ccn5 |
cellular communication network factor 5 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CCN5 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CCN5 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
cetrorelix results in increased expression of CDKN1A protein |
CTD |
PMID:21062912 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Chga |
chromogranin A |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate] results in decreased expression of CHGA mRNA |
CTD |
PMID:18160741 |
|
NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
|
|
G |
Clcf1 |
cardiotrophin-like cytokine factor 1 |
decreases expression |
ISO |
cetrorelix results in decreased expression of CLCF1 mRNA |
CTD |
PMID:21062912 |
|
NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605
|
|
G |
Cst9l |
cystatin 9-like |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of CST9L mRNA; [cetrorelix co-treated with testosterone enanthate] results in increased expression of CST9L mRNA |
CTD |
PMID:18160741 |
|
NCBI chr 3:136,288,093...136,290,906
Ensembl chr 3:136,288,093...136,290,906
|
|
G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
decreases expression |
ISO |
cetrorelix results in decreased expression of CXCL12 mRNA |
CTD |
PMID:21062912 |
|
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
|
|
G |
Cyb5a |
cytochrome b5 type A |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYB5A mRNA |
CTD |
PMID:18160741 |
|
NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
|
|
G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP11A1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYP11A1 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
|
|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP17A1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYP17A1 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
|
|
G |
Ddr1 |
discoidin domain receptor tyrosine kinase 1 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of DDR1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in increased expression of DDR1 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
|
|
G |
Dhcr24 |
24-dehydrocholesterol reductase |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of DHCR24 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of DHCR24 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
|
|
G |
Dpep3 |
dipeptidase 3 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of DPEP3 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of DPEP3 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr19:33,868,229...33,876,609
Ensembl chr19:33,868,242...33,873,896
|
|
G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO EXP |
cetrorelix results in increased expression of FAS mRNA; cetrorelix results in increased expression of FAS protein |
CTD |
PMID:17268770 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
|
|
G |
Fshb |
follicle stimulating hormone subunit beta |
decreases expression |
ISO EXP |
cetrorelix results in decreased expression of FSHB protein |
CTD |
PMID:10077358 PMID:17638707 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
|
|
G |
Gsta2 |
glutathione S-transferase alpha 2 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate] results in decreased expression of GSTA2 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
|
|
G |
Hcrtr1 |
hypocretin receptor 1 |
decreases expression |
EXP |
cetrorelix results in decreased expression of HCRTR1 mRNA |
CTD |
PMID:17638707 |
|
NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:142,477,214...142,486,674
|
|
G |
Hcrtr2 |
hypocretin receptor 2 |
decreases expression |
EXP |
cetrorelix results in decreased expression of HCRTR2 mRNA |
CTD |
PMID:17638707 |
|
NCBI chr 8:76,989,834...77,105,953
Ensembl chr 8:76,989,834...77,105,893
|
|
G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-CoA synthase 2 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of HMGCS2 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of HMGCS2 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
|
|
G |
Hsd17b6 |
hydroxysteroid (17-beta) dehydrogenase 6 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate] results in decreased expression of HSD17B6 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425
|
|
G |
Igf1 |
insulin-like growth factor 1 |
decreases expression |
ISO |
cetrorelix results in decreased expression of IGF1 mRNA |
CTD |
PMID:21062912 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
|
|
G |
Il6 |
interleukin 6 |
decreases expression |
ISO |
cetrorelix results in decreased expression of IL6 mRNA |
CTD |
PMID:21062912 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Insl3 |
insulin-like 3 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of INSL3 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of INSL3 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560
|
|
G |
Lhb |
luteinizing hormone subunit beta |
decreases expression multiple interactions decreases secretion |
EXP ISO |
cetrorelix results in decreased expression of LHB protein cypermethrin inhibits the reaction [cetrorelix results in decreased secretion of LHB protein] |
CTD |
PMID:10077358 PMID:16914592 PMID:17638707 PMID:28731686 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
ISO |
cetrorelix results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:21062912 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
ISO |
cetrorelix results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:21062912 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Msmo1 |
methylsterol monooxygenase 1 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate] results in decreased expression of MSMO1 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
|
|
G |
Papss2 |
3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PAPSS2 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PAPSS2 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331
|
|
G |
Pgrmc1 |
progesterone receptor membrane component 1 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PGRMC1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PGRMC1 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682
|
|
G |
Prl |
prolactin |
decreases expression |
EXP |
cetrorelix results in decreased expression of PRL protein |
CTD |
PMID:17638707 |
|
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
|
|
G |
Prok1 |
prokineticin 1 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PROK1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PROK1 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr 2:194,850,539...194,859,343
Ensembl chr 2:194,853,991...194,859,250
|
|
G |
Prps2 |
phosphoribosyl pyrophosphate synthetase 2 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate] results in decreased expression of PRPS2 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr X:26,975,915...27,013,184
Ensembl chr X:26,976,061...27,013,181
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
cetrorelix results in decreased phosphorylation of and results in decreased activity of RELA protein |
CTD |
PMID:21062912 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Rhob |
ras homolog family member B |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of RHOB mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of RHOB mRNA |
CTD |
PMID:18160741 |
|
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
|
|
G |
Star |
steroidogenic acute regulatory protein |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate] results in decreased expression of STAR mRNA |
CTD |
PMID:18160741 |
|
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
decreases phosphorylation |
ISO |
cetrorelix results in decreased phosphorylation of STAT3 protein |
CTD |
PMID:21062912 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
G |
Sycp1 |
synaptonemal complex protein 1 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of SYCP1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of SYCP1 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr 2:190,296,688...190,456,687
Ensembl chr 2:190,296,954...190,456,737
|
|
G |
Taf4b |
TATA-box binding protein associated factor 4b |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of TAF4B mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of TAF4B mRNA |
CTD |
PMID:18160741 |
|
NCBI chr18:5,952,737...6,086,408
Ensembl chr18:5,952,769...6,068,307
|
|
G |
Tex19.2 |
testis expressed gene 19.2 |
multiple interactions |
ISO |
[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of TEX19 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of TEX19 mRNA |
CTD |
PMID:18160741 |
|
NCBI chr10:106,379,757...106,382,344
Ensembl chr10:106,379,757...106,382,344
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression |
ISO |
cetrorelix results in decreased expression of TGFB1 mRNA |
CTD |
PMID:21062912 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tnfsf13 |
TNF superfamily member 13 |
decreases expression |
ISO |
cetrorelix results in decreased expression of TNFSF13 mRNA |
CTD |
PMID:21062912 |
|
NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042
|
|
G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
cetrorelix results in increased expression of TP53 protein |
CTD |
PMID:21062912 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
cetrorelix results in decreased expression of VEGFA mRNA |
CTD |
PMID:21062912 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
|
G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB mRNA]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB protein]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 protein]; CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]; CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]; CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]; CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]] |
CTD |
PMID:25446015 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Agtr2 |
angiotensin II receptor, type 2 |
multiple interactions |
ISO EXP |
CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]; CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]] [CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [CGP 42112A binds to and results in increased activity of AGTR2 protein] which results in increased abundance of and results in increased secretion of Triglycerides; [CGP 42112A binds to and results in increased activity of AGTR2 protein] which results in increased abundance of Fatty Acids, Nonesterified; CGP 42112A binds to and results in increased activity of AGTR2 protein |
CTD |
PMID:16003179 PMID:19151255 PMID:25446015 |
|
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
|
|
G |
Agtrap |
angiotensin II receptor-associated protein |
multiple interactions |
ISO |
CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]; CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]] |
CTD |
PMID:25446015 |
|
NCBI chr 5:158,507,427...158,519,036
Ensembl chr 5:158,508,749...158,519,036
|
|
G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions |
ISO |
CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB mRNA]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB protein]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of CYBB protein]] |
CTD |
PMID:25446015 |
|
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
|
|
G |
Nox1 |
NADPH oxidase 1 |
multiple interactions |
ISO |
CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]] |
CTD |
PMID:25446015 |
|
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
|
|
G |
Nox4 |
NADPH oxidase 4 |
multiple interactions |
ISO |
CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 protein]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]] |
CTD |
PMID:25446015 |
|
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
|
|
G |
Ube2v2 |
ubiquitin conjugating enzyme E2 V2 |
increases expression |
EXP |
CGP 42112A results in increased expression of UBE2V2 mRNA; CGP 42112A results in increased expression of UBE2V2 protein |
CTD |
PMID:17068200 |
|
NCBI chr11:85,304,528...85,338,430
Ensembl chr11:85,304,526...85,336,369
|
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
chlamydocin analog results in increased expression of CDKN1A protein |
CTD |
PMID:16439135 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Hdac1 |
histone deacetylase 1 |
decreases activity |
ISO |
chlamydocin analog results in decreased activity of HDAC1 protein |
CTD |
PMID:16439135 |
|
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
|
|
G |
Hdac4 |
histone deacetylase 4 |
decreases activity |
ISO |
chlamydocin analog results in decreased activity of HDAC4 protein |
CTD |
PMID:16439135 |
|
NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
|
|
G |
Hdac6 |
histone deacetylase 6 |
decreases activity |
ISO |
chlamydocin analog results in decreased activity of HDAC6 protein |
CTD |
PMID:16439135 |
|
NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441
|
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one promotes the reaction [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased expression of ACTA2 protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased expression of ACTA2 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [polyhexamethyleneguanidine results in increased expression of ACTA2 protein]] |
CTD |
PMID:31348943 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one promotes the reaction [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of AKT1 protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:31348943 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Tunicamycin results in increased secretion of APP protein modified form] |
CTD |
PMID:22115781 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of BAX protein N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]] |
CTD |
PMID:21209419 PMID:34897970 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of BCL2 protein N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in decreased expression of BCL2 protein]] |
CTD |
PMID:21209419 PMID:34897970 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Bmp6 |
bone morphogenetic protein 6 |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT10 mRNA] |
CTD |
PMID:23566955 |
|
NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP3 protein modified form]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of and results in increased activity of CASP3 protein |
CTD |
PMID:21209419 PMID:34897970 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP9 protein modified form]] |
CTD |
PMID:34897970 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of CCND1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of CCND1 mRNA] |
CTD |
PMID:19160421 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
[N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester co-treated with 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one] inhibits the reaction [polyhexamethyleneguanidine results in decreased expression of CDH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased secretion of CDH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium results in increased cleavage of CDH1 protein] |
CTD |
PMID:18791180 PMID:31348943 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
|
|
G |
Cdh2 |
cadherin 2 |
multiple interactions |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein] |
CTD |
PMID:23876460 |
|
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
|
|
G |
Csf1 |
colony stimulating factor 1 |
multiple interactions |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of CSF1 mRNA] |
CTD |
PMID:24223152 |
|
NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
|
|
G |
Eno2 |
enolase 2 |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of ENO2 mRNA] |
CTD |
PMID:24929042 |
|
NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
|
|
G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of FLT1 protein] |
CTD |
PMID:21843347 |
|
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
|
|
G |
Foxo3 |
forkhead box O3 |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [Hydrogen Peroxide results in increased expression of FOXO3 protein] |
CTD |
PMID:25108166 |
|
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
|
|
G |
Hes1 |
hes family bHLH transcription factor 1 |
multiple interactions decreases expression |
ISO EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HES1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HES1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Hydrogen Peroxide results in increased expression of HES1 protein] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of HES1 protein N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of HES1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [tetrabromobisphenol A results in increased expression of HES1 mRNA] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of HES1 protein] |
CTD |
PMID:19160421 PMID:24223152 PMID:25005833 PMID:25108166 PMID:32041402 PMID:36988346 More...
|
|
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
|
|
G |
Hey1 |
hes-related family bHLH transcription factor with YRPW motif 1 |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA] |
CTD |
PMID:19160421 |
|
NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312
|
|
G |
Hey2 |
hes-related family bHLH transcription factor with YRPW motif 2 |
multiple interactions |
ISO EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY2 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [tetrabromobisphenol A results in increased expression of HEY2 mRNA] |
CTD |
PMID:19160421 PMID:32041402 |
|
NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein] |
CTD |
PMID:25108166 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
|
|
G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of HMGB1 protein] |
CTD |
PMID:21843347 |
|
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
|
|
G |
Il10 |
interleukin 10 |
multiple interactions |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL10 mRNA] |
CTD |
PMID:24223152 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL1B protein] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL1B protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA] |
CTD |
PMID:21843347 PMID:24223152 PMID:36988346 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL6 mRNA] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein] |
CTD |
PMID:21843347 PMID:24223152 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of ITGAM protein] |
CTD |
PMID:28130038 |
|
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
|
|
G |
Ivl |
involucrin |
decreases expression |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of IVL mRNA; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of IVL protein |
CTD |
PMID:18633435 |
|
NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
|
|
G |
Jag1 |
jagged canonical Notch ligand 1 |
decreases expression |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of JAG1 mRNA; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of JAG1 protein |
CTD |
PMID:18633435 |
|
NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209
|
|
G |
Krt1 |
keratin 1 |
multiple interactions decreases expression |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [U 0126 results in increased expression of KRT1 mRNA] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of KRT1 mRNA |
CTD |
PMID:18633435 PMID:23566955 |
|
NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
|
|
G |
Krt10 |
keratin 10 |
multiple interactions decreases expression |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT10 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [U 0126 results in increased expression of KRT10 mRNA] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of KRT10 mRNA; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of KRT10 protein |
CTD |
PMID:18633435 PMID:23566955 |
|
NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
|
|
G |
Lgr5 |
leucine rich repeat containing G protein coupled receptor 5 |
multiple interactions |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [tetrabromobisphenol A results in increased expression of LGR5 mRNA] |
CTD |
PMID:32041402 |
|
NCBI chr 7:51,087,059...51,221,882
Ensembl chr 7:51,088,239...51,222,446
|
|
G |
Map2 |
microtubule-associated protein 2 |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of MAP2 mRNA] |
CTD |
PMID:24929042 |
|
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
|
|
G |
Mdm2 |
MDM2 proto-oncogene |
multiple interactions increases expression |
ISO |
Hydrogen Peroxide inhibits the reaction [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of MDM2 protein] |
CTD |
PMID:25005833 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
|
|
G |
Mir141 |
microRNA 141 |
multiple interactions |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in decreased expression of BCL2 protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP3 protein modified form]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP9 protein modified form]] |
CTD |
PMID:34897970 |
|
NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332
|
|
G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
ISO EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 protein] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA] |
CTD |
PMID:24223152 |
|
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of NOS2 protein] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of NOS2 mRNA] |
CTD |
PMID:24223152 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Notch1 |
notch receptor 1 |
multiple interactions decreases expression |
ISO EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Hydrogen Peroxide results in increased cleavage of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [phenethyl isothiocyanate results in increased cleavage of and results in increased activity of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased cleavage of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [polyhexamethyleneguanidine results in increased cleavage of NOTCH1 protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased cleavage of and results in decreased activity of NOTCH1 protein N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of NOTCH1 protein N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NOTCH1 protein] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency affects the localization of NOTCH1 protein modified form]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Tunicamycin results in increased cleavage of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [Oxygen deficiency results in increased expression of NOTCH1 protein] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of NOTCH1 protein modified form |
CTD |
PMID:18633435 PMID:22039516 PMID:22115781 PMID:24223152 PMID:25108166 PMID:25118938 PMID:28130038 PMID:31348943 PMID:36988346 More...
|
|
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
|
|
G |
Notch2 |
notch receptor 2 |
multiple interactions decreases expression |
ISO EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased cleavage of and results in decreased activity of NOTCH2 protein N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NOTCH2 protein] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of NOTCH2 protein |
CTD |
PMID:22039516 PMID:36988346 |
|
NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
|
|
G |
Notch3 |
notch receptor 3 |
decreases expression |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of NOTCH3 protein |
CTD |
PMID:36988346 |
|
NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025
|
|
G |
Notch4 |
notch receptor 4 |
decreases expression |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of NOTCH4 protein |
CTD |
PMID:36988346 |
|
NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465
|
|
G |
Numb |
NUMB, endocytic adaptor protein |
increases expression |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of NUMB protein |
CTD |
PMID:25005833 |
|
NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354
|
|
G |
Pml |
PML nuclear body scaffold |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]] |
CTD |
PMID:28130038 |
|
NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
|
|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases expression multiple interactions |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of PPARA protein N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of PPARA protein] |
CTD |
PMID:36988346 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium results in increased expression of PTGS2 mRNA] |
CTD |
PMID:18791180 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rara |
retinoic acid receptor, alpha |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]] |
CTD |
PMID:28130038 |
|
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
|
|
G |
Rbpj |
recombination signal binding protein for immunoglobulin kappa J region |
multiple interactions increases expression |
EXP ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of RBPJ mRNA] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of RBPJ protein N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cycloheximide results in decreased expression of RBPJ protein] |
CTD |
PMID:22302987 PMID:24223152 |
|
NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency affects the localization of RELA protein modified form]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of RELA protein] |
CTD |
PMID:24223152 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TGFB1 mRNA] |
CTD |
PMID:24223152 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TLR4 mRNA] |
CTD |
PMID:24223152 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TNF protein] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA] |
CTD |
PMID:24223152 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tp53 |
tumor protein p53 |
decreases expression multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of TP53 protein Hydrogen Peroxide inhibits the reaction [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of TP53 protein] |
CTD |
PMID:25005833 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Traf6 |
TNF receptor associated factor 6 |
multiple interactions |
ISO EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TRAF6 protein] N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TRAF6 mRNA] |
CTD |
PMID:24223152 |
|
NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
|
|
G |
Tubb3 |
tubulin, beta 3 class III |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of TUBB3 mRNA] |
CTD |
PMID:24929042 |
|
NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of VEGFA protein] |
CTD |
PMID:21843347 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
G |
Vil1 |
villin 1 |
multiple interactions |
EXP |
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [tetrabromobisphenol A results in increased expression of VIL1 mRNA] |
CTD |
PMID:32041402 |
|
NCBI chr 9:75,991,141...76,018,860
Ensembl chr 9:75,991,141...76,018,858
|
|
|
G |
Gnrhr |
gonadotropin releasing hormone receptor |
increases transport multiple interactions |
ISO |
GNRHR protein results in increased transport of deslorelin 2,4-Dinitrophenol inhibits the reaction [GNRHR protein results in increased transport of deslorelin]; Buserelin inhibits the reaction [GNRHR protein results in increased transport of deslorelin] |
CTD |
PMID:15212170 |
|
NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
|
|
|
G |
Oprd1 |
opioid receptor, delta 1 |
multiple interactions affects binding |
EXP |
Cadmium inhibits the reaction [enkephalin, Ser(2), Leu(5), Thr(6)- binds to OPRD1 protein]; Copper inhibits the reaction [enkephalin, Ser(2), Leu(5), Thr(6)- binds to OPRD1 protein]; Mercury inhibits the reaction [enkephalin, Ser(2), Leu(5), Thr(6)- binds to OPRD1 protein] |
CTD |
PMID:2162496 |
|
NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
|
|
|
G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
increases transport |
ISO |
ABCC4 protein results in increased transport of Enalapril |
CTD |
PMID:17939016 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
|
|
G |
Ace |
angiotensin I converting enzyme |
decreases activity multiple interactions increases expression |
ISO EXP |
Enalapril results in decreased activity of ACE protein Enalapril inhibits the reaction [Dexamethasone results in increased expression of ACE protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein]]; Enalapril inhibits the reaction [Formaldehyde results in increased expression of ACE protein] ACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride]; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form] Enalapril results in increased expression of ACE mRNA Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Enalapril promotes the reaction [Folic Acid results in increased expression of ACE mRNA] |
CTD |
PMID:15728788 PMID:15816410 PMID:20679179 PMID:20829712 PMID:23733546 PMID:28973481 PMID:30940551 PMID:36706861 More...
|
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression |
EXP |
Enalapril results in decreased expression of ACTA2 protein |
CTD |
PMID:19349682 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
|
|
G |
Acvrl1 |
activin A receptor like type 1 |
decreases expression |
EXP |
Enalapril results in decreased expression of ACVRL1 protein |
CTD |
PMID:12883979 |
|
NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591
|
|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression |
ISO |
Enalapril results in increased expression of ADIPOQ protein |
CTD |
PMID:25037058 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
|
|
G |
Adrb1 |
adrenoceptor beta 1 |
increases expression |
EXP |
Enalapril results in increased expression of ADRB1 protein |
CTD |
PMID:7586371 |
|
NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
|
|
G |
Agt |
angiotensinogen |
decreases activity affects response to substance increases expression decreases response to substance multiple interactions decreases expression |
EXP ISO |
Enalapril results in decreased activity of AGT protein modified form AGT gene alternative form affects the susceptibility to Enalapril; AGT protein polymorphism affects the susceptibility to Enalapril Enalapril results in increased expression of AGT mRNA Enalapril results in decreased susceptibility to AGT protein modified form Enalapril affects the reaction [chymostatin results in decreased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [Cyclosporine results in increased expression of AGT protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of AGT protein] Enalapril results in decreased expression of AGT protein modified form [Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone] Enalapril results in decreased expression of AGT mRNA |
CTD |
PMID:1330361 PMID:2474097 PMID:6319675 PMID:12003776 PMID:12911327 PMID:14659064 PMID:16685205 PMID:18300870 PMID:18679781 PMID:18796534 PMID:19114890 PMID:20829712 PMID:21602471 More...
|
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Agtr1a |
angiotensin II receptor, type 1a |
increases expression multiple interactions decreases expression affects expression |
EXP ISO |
Enalapril results in increased expression of AGTR1A mRNA Enalapril inhibits the reaction [Dexamethasone results in increased expression of AGTR1 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of AGTR1 protein]]; Enalapril inhibits the reaction [Formaldehyde results in increased expression of AGTR1 protein] Enalapril results in decreased expression of AGTR1A mRNA Enalapril inhibits the reaction [Cyclosporine results in decreased expression of AGTR1A mRNA] Enalapril affects the expression of AGTR1A mRNA |
CTD |
PMID:14659064 PMID:18403896 PMID:18765277 PMID:18796534 PMID:30940551 PMID:36706861 More...
|
|
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
|
|
G |
Agtr2 |
angiotensin II receptor, type 2 |
increases expression decreases expression |
EXP |
Enalapril results in increased expression of AGTR2 mRNA Enalapril results in decreased expression of AGTR2 mRNA |
CTD |
PMID:9740612 PMID:18403896 PMID:18765277 |
|
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
Enalapril promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:18806606 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Corticosterone results in decreased expression of ALPL mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of ALPL mRNA] |
CTD |
PMID:30423288 PMID:31887396 |
|
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
|
|
G |
Ang |
angiogenin |
decreases expression |
ISO |
Enalapril results in decreased expression of ANG protein |
CTD |
PMID:3038326 |
|
NCBI chr15:24,312,711...24,323,361
|
|
G |
Angpt2 |
angiopoietin 2 |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Streptozocin results in increased expression of ANGPT2 mRNA] |
CTD |
PMID:19958114 |
|
NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
|
|
G |
Apoe |
apolipoprotein E |
multiple interactions |
ISO |
[Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein Enalapril inhibits the reaction [APOE gene mutant form results in decreased abundance of Antioxidants]; Enalapril inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol] |
CTD |
PMID:19603250 PMID:25037058 |
|
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
|
|
G |
Atf2 |
activating transcription factor 2 |
increases expression |
EXP |
Enalapril results in increased expression of ATF2 protein |
CTD |
PMID:15531746 |
|
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
|
|
G |
Atp1a2 |
ATPase Na+/K+ transporting subunit alpha 2 |
increases expression |
EXP |
Enalapril results in increased expression of ATP1A2 mRNA; Enalapril results in increased expression of ATP1A2 protein |
CTD |
PMID:18418421 |
|
NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
|
|
G |
Atp1a3 |
ATPase Na+/K+ transporting subunit alpha 3 |
decreases expression |
EXP |
Enalapril results in decreased expression of ATP1A3 mRNA; Enalapril results in decreased expression of ATP1A3 protein |
CTD |
PMID:18418421 |
|
NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
|
|
G |
Avp |
arginine vasopressin |
multiple interactions |
EXP |
Enalapril promotes the reaction [Dexamethasone results in increased activity of AVP protein] |
CTD |
PMID:3346065 |
|
NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
decreases expression |
EXP |
Enalapril results in decreased expression of BAX protein |
CTD |
PMID:21153712 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression multiple interactions |
EXP |
Enalapril results in increased expression of BCL2 protein Enalapril inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein] |
CTD |
PMID:21153712 PMID:30623541 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Bdkrb1 |
bradykinin receptor B1 |
increases expression multiple interactions |
EXP |
Enalapril results in increased expression of BDKRB1 mRNA [kallidin, des-Arg(10)- results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Enalapril |
CTD |
PMID:18796534 PMID:21430409 |
|
NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
|
|
G |
Bdkrb2 |
bradykinin receptor B2 |
increases expression |
EXP |
Enalapril results in increased expression of BDKRB2 mRNA; Enalapril results in increased expression of BDKRB2 protein |
CTD |
PMID:18190998 |
|
NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
|
|
G |
Becn1 |
beclin 1 |
increases expression |
EXP |
Enalapril results in increased expression of BECN1 protein |
CTD |
PMID:30563025 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
|
|
G |
Bglap |
bone gamma-carboxyglutamate protein |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Corticosterone results in decreased expression of BGLAP mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of BGLAP mRNA] |
CTD |
PMID:30423288 PMID:31887396 |
|
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
|
|
G |
Car2 |
carbonic anhydrase 2 |
decreases activity |
ISO |
Enalapril results in decreased activity of CA2 protein |
CTD |
PMID:28126276 |
|
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
|
|
G |
Casp3 |
caspase 3 |
decreases activity multiple interactions |
EXP |
Enalapril results in decreased activity of CASP3 protein Enalapril inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein] |
CTD |
PMID:21153712 PMID:30623541 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
decreases activity |
EXP |
Enalapril results in decreased activity of CASP9 protein |
CTD |
PMID:21153712 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cat |
catalase |
increases activity multiple interactions |
EXP |
Enalapril results in increased activity of CAT protein Enalapril inhibits the reaction [Isoproterenol results in decreased expression of CAT protein] |
CTD |
PMID:12124199 PMID:30623541 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions decreases expression |
EXP ISO |
[paricalcitol co-treated with Enalapril] results in decreased expression of CCL2 protein Enalapril inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein] Enalapril results in decreased expression of CCL2 protein Enalapril results in decreased expression of CCL2 mRNA |
CTD |
PMID:10925121 PMID:17513326 PMID:19627010 PMID:20720404 PMID:25037058 PMID:28973481 More...
|
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Ccn2 |
cellular communication network factor 2 |
decreases expression multiple interactions |
EXP ISO |
Enalapril results in decreased expression of CCN2 mRNA; Enalapril results in decreased expression of CCN2 protein Enalapril inhibits the reaction [Streptozocin results in increased expression of CCN2 protein] |
CTD |
PMID:18812665 PMID:19349682 PMID:21416479 PMID:25037058 |
|
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
|
|
G |
Cela2a |
chymotrypsin like elastase 2A |
decreases expression |
EXP |
Enalapril results in decreased expression of CELA2A mRNA |
CTD |
PMID:21602471 |
|
NCBI chr 5:154,126,879...154,136,630
Ensembl chr 5:154,126,878...154,136,632
|
|
G |
Cltrn |
collectrin, amino acid transport regulator |
decreases expression |
EXP |
Enalapril results in decreased expression of CLTRN mRNA; Enalapril results in decreased expression of CLTRN protein |
CTD |
PMID:12887829 |
|
NCBI chr X:30,361,967...30,395,264
Ensembl chr X:30,361,967...30,395,349
|
|
G |
Clu |
clusterin |
decreases expression |
EXP |
Enalapril results in decreased expression of CLU protein |
CTD |
PMID:12193663 |
|
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
|
|
G |
Cma1 |
chymase 1 |
decreases expression |
EXP |
Enalapril results in decreased expression of CMA1 mRNA |
CTD |
PMID:18796534 |
|
NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
Enalapril inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA] |
CTD |
PMID:12003776 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
|
|
G |
Col3a1 |
collagen type III alpha 1 chain |
decreases expression increases expression |
EXP ISO |
Enalapril results in decreased expression of COL3A1 mRNA Enalapril results in increased expression of COL3A1 mRNA |
CTD |
PMID:17164399 PMID:25037058 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
|
|
G |
Col4a1 |
collagen type IV alpha 1 chain |
multiple interactions decreases expression |
EXP |
[eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA] Enalapril results in decreased expression of COL4A1 mRNA; Enalapril results in decreased expression of COL4A1 protein |
CTD |
PMID:9175058 PMID:18682491 |
|
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
|
|
G |
Cs |
citrate synthase |
increases activity |
EXP |
Enalapril results in increased activity of CS protein |
CTD |
PMID:30563025 |
|
NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
|
|
G |
Cyba |
cytochrome b-245 alpha chain |
multiple interactions decreases expression |
ISO |
[paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein Enalapril results in decreased expression of CYBA protein |
CTD |
PMID:20720404 PMID:25037058 |
|
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
|
|
G |
Cycs |
cytochrome c, somatic |
affects localization |
EXP |
Enalapril affects the localization of CYCS protein |
CTD |
PMID:21153712 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
Enalapril inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] |
CTD |
PMID:19299527 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
|
|
G |
Edn1 |
endothelin 1 |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] |
CTD |
PMID:9175058 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
|
|
G |
Eng |
endoglin |
multiple interactions |
ISO |
[Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA |
CTD |
PMID:25037058 |
|
NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
|
|
G |
Epo |
erythropoietin |
decreases expression multiple interactions |
ISO EXP |
Enalapril results in decreased expression of EPO protein Enalapril inhibits the reaction [Streptozocin results in increased expression of EPO mRNA] |
CTD |
PMID:2474097 PMID:9434678 PMID:19958114 |
|
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
|
|
G |
Epor |
erythropoietin receptor |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR protein] |
CTD |
PMID:19958114 |
|
NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
|
|
G |
F3 |
coagulation factor III, tissue factor |
decreases expression multiple interactions |
ISO |
Enalapril results in decreased expression of F3 protein Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein] |
CTD |
PMID:18060435 PMID:22188725 |
|
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
|
|
G |
Faslg |
Fas ligand |
decreases expression |
EXP |
Enalapril results in decreased expression of FASLG mRNA |
CTD |
PMID:10925121 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
|
|
G |
Gh1 |
growth hormone 1 |
increases response to substance |
ISO |
GH1 protein results in increased susceptibility to Enalapril |
CTD |
PMID:12883983 |
|
NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
|
|
G |
Gja5 |
gap junction protein, alpha 5 |
multiple interactions |
ISO |
GJA5 affects the reaction [Enalapril results in increased secretion of REN protein] |
CTD |
PMID:19109587 |
|
NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
|
|
G |
Gjc1 |
gap junction protein, gamma 1 |
multiple interactions |
ISO |
GJC1 affects the reaction [Enalapril results in increased secretion of REN protein] |
CTD |
PMID:19109587 |
|
NCBI chr10:87,758,192...87,785,443
Ensembl chr10:87,760,528...87,785,867
|
|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein] |
CTD |
PMID:18806606 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
|
|
G |
Has2 |
hyaluronan synthase 2 |
increases expression |
EXP |
Enalapril results in increased expression of HAS2 mRNA |
CTD |
PMID:20933085 |
|
NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
|
|
G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
EXP ISO |
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein] Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of HMGB1 protein] |
CTD |
PMID:19114890 |
|
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression |
EXP |
Enalapril results in increased expression of HMOX1 protein |
CTD |
PMID:21263376 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hyal1 |
hyaluronidase 1 |
decreases expression |
EXP |
Enalapril results in decreased expression of HYAL1 mRNA; Enalapril results in decreased expression of HYAL1 protein |
CTD |
PMID:20933085 |
|
NCBI chr 8:108,250,668...108,254,519
Ensembl chr 8:108,250,667...108,260,210
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression multiple interactions |
EXP ISO |
Enalapril results in decreased expression of ICAM1 protein Enalapril inhibits the reaction [sodium arsenite results in increased secretion of ICAM1 protein modified form] [Enalapril co-treated with paricalcitol] results in decreased expression of ICAM1 mRNA Enalapril results in decreased expression of ICAM1 protein modified form |
CTD |
PMID:14716214 PMID:17347482 PMID:25037058 PMID:28973481 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Igf1 |
insulin-like growth factor 1 |
affects expression decreases expression |
EXP |
Enalapril affects the expression of IGF1 protein Enalapril results in decreased expression of IGF1 mRNA |
CTD |
PMID:12883983 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
|
|
G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression |
EXP |
Enalapril results in increased expression of IGFBP1 mRNA |
CTD |
PMID:12883983 |
|
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
|
|
G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein] |
CTD |
PMID:17299153 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions decreases expression |
EXP ISO |
Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA] Enalapril results in decreased expression of IL1B mRNA |
CTD |
PMID:17167242 PMID:21265103 PMID:25037058 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions affects response to substance |
EXP ISO |
Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA] Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL6 protein] IL6 gene polymorphism affects the susceptibility to Enalapril |
CTD |
PMID:15342284 PMID:17167242 PMID:19114890 PMID:21265103 PMID:30623541 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Irak1 |
interleukin-1 receptor-associated kinase 1 |
multiple interactions |
ISO |
[Atorvastatin co-treated with Enalapril] results in decreased expression of IRAK1 mRNA |
CTD |
PMID:20524934 |
|
NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521
|
|
G |
Itga2 |
integrin subunit alpha 2 |
decreases expression |
ISO |
Enalapril results in decreased expression of ITGA2 mRNA |
CTD |
PMID:25037058 |
|
NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
|
|
G |
Kdr |
kinase insert domain receptor |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] |
CTD |
PMID:12110003 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
|
|
G |
Kng1 |
kininogen 1 |
increases response to substance |
EXP |
Enalapril results in increased susceptibility to KNG1 protein modified form |
CTD |
PMID:18190998 |
|
NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
|
|
G |
Lamb1 |
laminin subunit beta 1 |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA] |
CTD |
PMID:9175058 |
|
NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585
|
|
G |
Lamb2 |
laminin subunit beta 2 |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA] |
CTD |
PMID:9175058 |
|
NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549
|
|
G |
Lep |
leptin |
increases response to substance |
ISO |
LEP protein results in increased susceptibility to Enalapril |
CTD |
PMID:20614101 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
|
|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases expression increases phosphorylation |
EXP |
Enalapril results in increased expression of MAPK9 mRNA; Enalapril results in increased expression of MAPK9 protein Enalapril results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:15531746 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
|
|
G |
Mfn2 |
mitofusin 2 |
increases expression |
EXP |
Enalapril results in increased expression of MFN2 protein |
CTD |
PMID:30563025 |
|
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
|
|
G |
Mir146a |
microRNA 146a |
multiple interactions |
ISO |
[Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146A |
CTD |
PMID:20524934 |
|
NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
|
|
G |
Mir146b |
microRNA 146b |
multiple interactions |
ISO |
[Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146B |
CTD |
PMID:20524934 |
|
NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525
|
|
G |
Mmp3 |
matrix metallopeptidase 3 |
decreases expression |
ISO |
Enalapril results in decreased expression of MMP3 mRNA |
CTD |
PMID:25037058 |
|
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased activity of MPO protein] |
CTD |
PMID:19114890 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Myh6 |
myosin heavy chain 6 |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein] |
CTD |
PMID:15362513 |
|
NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
|
|
G |
Myh7 |
myosin heavy chain 7 |
decreases expression multiple interactions |
EXP |
Enalapril results in decreased expression of MYH7 mRNA Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 protein] |
CTD |
PMID:15362513 PMID:21423293 |
|
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
|
|
G |
Ndst1 |
N-deacetylase and N-sulfotransferase 1 |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein] |
CTD |
PMID:15793251 |
|
NCBI chr18:54,136,887...54,199,545
Ensembl chr18:54,140,779...54,178,191
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases expression |
EXP |
Enalapril results in decreased expression of NFE2L2 mRNA |
CTD |
PMID:18765277 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
decreases activity multiple interactions |
EXP |
Enalapril results in decreased activity of NFKB1 protein Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 protein] |
CTD |
PMID:19225048 PMID:21265102 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased degradation of and results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:19114890 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Noa1 |
nitric oxide associated 1 |
increases expression increases activity |
EXP |
Enalapril results in increased expression of NOA1 mRNA Enalapril results in increased activity of NOA1 protein |
CTD |
PMID:14588141 |
|
NCBI chr14:30,835,264...30,851,294
Ensembl chr14:30,835,247...30,851,293
|
|
G |
Nos2 |
nitric oxide synthase 2 |
decreases expression multiple interactions |
EXP ISO |
Enalapril results in decreased expression of NOS2 protein [paricalcitol co-treated with Enalapril] results in decreased expression of NOS2 protein |
CTD |
PMID:20720404 PMID:21377515 PMID:25037058 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions increases expression affects expression |
EXP ISO |
[Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA; Enalapril inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein] Enalapril results in increased expression of NOS3 protein [paricalcitol co-treated with Enalapril] results in increased expression of NOS3 protein; Enalapril inhibits the reaction [Dexamethasone results in decreased expression of NOS3 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in decreased expression of NOS3 protein]] Enalapril affects the expression of NOS3 mRNA |
CTD |
PMID:12176110 PMID:16197366 PMID:20571278 PMID:20720404 PMID:25037058 PMID:30940551 More...
|
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
|
|
G |
Nppa |
natriuretic peptide A |
decreases expression |
ISO EXP |
Enalapril results in decreased expression of NPPA protein Enalapril results in decreased expression of NPPA mRNA |
CTD |
PMID:2136812 PMID:8112904 PMID:21423293 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
|
|
G |
Nppb |
natriuretic peptide B |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Isoproterenol results in increased expression of NPPB protein] |
CTD |
PMID:18806606 |
|
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
|
|
G |
Nr3c2 |
nuclear receptor subfamily 3, group C, member 2 |
increases expression |
EXP |
Enalapril results in increased expression of NR3C2 mRNA |
CTD |
PMID:18796534 |
|
NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
|
|
G |
Nrf1 |
nuclear respiratory factor 1 |
increases expression |
EXP |
Enalapril results in increased expression of NRF1 mRNA |
CTD |
PMID:18765277 |
|
NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
|
|
G |
Pdpn |
podoplanin |
increases expression |
EXP |
Enalapril results in increased expression of PDPN protein |
CTD |
PMID:20933085 |
|
NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
|
|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
[Enalapril co-treated with Glucose] binds to PPARA protein; Enalapril inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] |
CTD |
PMID:18812576 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression multiple interactions |
EXP |
Enalapril results in decreased expression of PPARG protein Enalapril inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein] |
CTD |
PMID:19225048 PMID:30623541 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
EXP |
Enalapril results in increased expression of PPARGC1A mRNA |
CTD |
PMID:18765277 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
|
|
G |
Prdx3 |
peroxiredoxin 3 |
increases expression |
EXP |
Enalapril results in increased expression of PRDX3 protein |
CTD |
PMID:30563025 |
|
NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
|
|
G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
increases expression |
ISO |
Enalapril results in increased expression of PRKAA1 protein |
CTD |
PMID:25037058 |
|
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
|
|
G |
Prkca |
protein kinase C, alpha |
decreases expression |
EXP |
Enalapril results in decreased expression of PRKCA protein modified form |
CTD |
PMID:21565836 |
|
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
|
|
G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
decreases expression |
ISO |
Enalapril results in decreased expression of PTGS1 mRNA |
CTD |
PMID:25037058 |
|
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression multiple interactions |
EXP ISO |
Enalapril results in decreased expression of PTGS2 protein [paricalcitol co-treated with Enalapril] results in decreased expression of PTGS2 protein |
CTD |
PMID:20720404 PMID:21377515 PMID:25037058 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Pth1r |
parathyroid hormone 1 receptor |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein] |
CTD |
PMID:15728788 |
|
NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729
|
|
G |
Pthlh |
parathyroid hormone-like hormone |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein] |
CTD |
PMID:15728788 |
|
NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Isoproterenol results in increased expression of RELA protein] |
CTD |
PMID:30623541 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Ren |
renin |
multiple interactions increases expression increases secretion decreases activity increases activity |
ISO EXP |
[Indomethacin co-treated with Enalapril] results in decreased expression of REN protein; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone] Enalapril results in increased expression of REN mRNA; Enalapril results in increased expression of REN protein Enalapril results in increased secretion of REN protein [Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA; GJA5 affects the reaction [Enalapril results in increased secretion of REN protein]; GJC1 affects the reaction [Enalapril results in increased secretion of REN protein]; REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]; Sodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]; Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]; Sodium inhibits the reaction [Enalapril results in increased secretion of REN protein] Enalapril results in decreased activity of REN protein Enalapril results in increased activity of REN protein |
CTD |
PMID:1330361 PMID:2994932 PMID:6094050 PMID:11078175 PMID:12434137 PMID:17846348 PMID:18679781 PMID:18796534 PMID:19109587 PMID:19536436 PMID:19767874 PMID:21423293 PMID:21424707 More...
|
|
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
|
|
G |
Runx2 |
RUNX family transcription factor 2 |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Corticosterone results in decreased expression of RUNX2 mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of RUNX2 mRNA] |
CTD |
PMID:30423288 PMID:31887396 |
|
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
|
|
G |
Sele |
selectin E |
multiple interactions |
ISO |
Enalapril inhibits the reaction [sodium arsenite results in increased expression of SELE protein] |
CTD |
PMID:28973481 |
|
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
|
|
G |
Sell |
selectin L |
multiple interactions |
ISO |
[Enalapril co-treated with paricalcitol] results in decreased expression of SELL mRNA |
CTD |
PMID:25037058 |
|
NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
|
|
G |
Selp |
selectin P |
multiple interactions decreases expression |
EXP ISO |
Enalapril inhibits the reaction [Diclofenac results in decreased expression of SELP protein] Enalapril results in decreased expression of SELP mRNA |
CTD |
PMID:14716214 PMID:25037058 |
|
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
|
|
G |
Serpinb2 |
serpin family B member 2 |
decreases expression |
ISO |
Enalapril results in decreased expression of SERPINB2 mRNA |
CTD |
PMID:25037058 |
|
NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
|
|
G |
Serpine1 |
serpin family E member 1 |
multiple interactions decreases expression |
EXP |
[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein] Enalapril results in decreased expression of SERPINE1 mRNA; Enalapril results in decreased expression of SERPINE1 protein |
CTD |
PMID:18682491 |
|
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
|
|
G |
Slc15a2 |
solute carrier family 15 member 2 |
multiple interactions |
ISO |
Enalapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] |
CTD |
PMID:18713951 |
|
NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
|
|
G |
Slc22a12 |
solute carrier family 22 member 12 |
multiple interactions |
ISO |
Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] |
CTD |
PMID:21272127 |
|
NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
|
|
G |
Slc22a7 |
solute carrier family 22 member 7 |
multiple interactions |
ISO |
Enalapril inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] |
CTD |
PMID:12065749 |
|
NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
|
|
G |
Slc22a8 |
solute carrier family 22 member 8 |
multiple interactions |
ISO |
Enalapril inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid] |
CTD |
PMID:15100168 |
|
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
|
|
G |
Smad2 |
SMAD family member 2 |
multiple interactions |
EXP |
Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein] |
CTD |
PMID:17513326 |
|
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
|
|
G |
Smad7 |
SMAD family member 7 |
increases expression |
EXP |
Enalapril results in increased expression of SMAD7 mRNA; Enalapril results in increased expression of SMAD7 protein |
CTD |
PMID:19197123 PMID:19349682 |
|
NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions increases expression |
ISO |
[paricalcitol co-treated with Enalapril] results in increased expression of SOD1 protein Enalapril results in increased expression of SOD1 protein |
CTD |
PMID:20720404 PMID:25037058 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G |
Sod2 |
superoxide dismutase 2 |
decreases activity increases expression decreases expression multiple interactions |
EXP ISO |
Enalapril results in decreased activity of SOD2 protein Enalapril results in increased expression of SOD2 protein Enalapril results in decreased expression of SOD2 protein [paricalcitol co-treated with Enalapril] results in decreased expression of SOD2 protein |
CTD |
PMID:18765277 PMID:20720404 PMID:25037058 PMID:30563025 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Spp1 |
secreted phosphoprotein 1 |
multiple interactions |
ISO EXP |
[Enalapril co-treated with paricalcitol] results in decreased expression of SPP1 mRNA Enalapril inhibits the reaction [Corticosterone results in decreased expression of SPP1 mRNA]; Enalapril inhibits the reaction [Ethanol results in decreased expression of SPP1 mRNA] |
CTD |
PMID:25037058 PMID:30423288 PMID:31887396 |
|
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
|
|
G |
Sqstm1 |
sequestosome 1 |
increases expression |
EXP |
Enalapril results in increased expression of SQSTM1 protein |
CTD |
PMID:30563025 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
|
|
G |
Ssbp1 |
single stranded DNA binding protein 1 |
increases expression |
EXP |
Enalapril results in increased expression of SSBP1 mRNA |
CTD |
PMID:18765277 |
|
NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 protein] |
CTD |
PMID:19958114 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
G |
Tek |
TEK receptor tyrosine kinase |
multiple interactions |
EXP |
Enalapril inhibits the reaction [Streptozocin results in increased expression of TEK mRNA] |
CTD |
PMID:19958114 |
|
NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
|
|
G |
Tfam |
transcription factor A, mitochondrial |
increases expression |
EXP |
Enalapril results in increased expression of TFAM protein |
CTD |
PMID:30563025 |
|
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions decreases expression |
EXP |
[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 mRNA]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 protein] Enalapril results in decreased expression of TGFB1 mRNA; Enalapril results in decreased expression of TGFB1 protein |
CTD |
PMID:12883979 PMID:15309289 PMID:17164399 PMID:17513326 PMID:18682491 PMID:19197123 PMID:19349682 PMID:23733546 More...
|
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tgfb2 |
transforming growth factor, beta 2 |
decreases expression |
EXP |
Enalapril results in decreased expression of TGFB2 mRNA |
CTD |
PMID:17164399 |
|
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
|
|
G |
Tgfbi |
transforming growth factor, beta induced |
decreases secretion multiple interactions |
EXP |
Enalapril results in decreased secretion of TGFBI protein [eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein |
CTD |
PMID:18682491 |
|
NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240
|
|
G |
Tgfbr1 |
transforming growth factor, beta receptor 1 |
decreases expression |
EXP |
Enalapril results in decreased expression of TGFBR1 mRNA; Enalapril results in decreased expression of TGFBR1 protein |
CTD |
PMID:12883979 |
|
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
|
|
G |
Thbs4 |
thrombospondin 4 |
increases expression |
ISO |
Enalapril results in increased expression of THBS4 mRNA |
CTD |
PMID:25037058 |
|
NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
|
|
G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
[Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 protein |
CTD |
PMID:20524934 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
|
|
G |
Tnf |
tumor necrosis factor |
decreases expression multiple interactions |
EXP ISO |
Enalapril results in decreased expression of TNF protein Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA] [paricalcitol co-treated with Enalapril] results in decreased expression of TNF protein; Enalapril inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein] Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein] |
CTD |
PMID:12003776 PMID:16336586 PMID:17167242 PMID:17299153 PMID:18060435 PMID:19114890 PMID:19225048 PMID:20720404 PMID:25037058 PMID:30623541 More...
|
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tomm20 |
translocase of outer mitochondrial membrane 20 |
decreases expression |
EXP |
Enalapril results in decreased expression of TOMM20 mRNA |
CTD |
PMID:18765277 |
|
NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198
|
|
G |
Traf6 |
TNF receptor associated factor 6 |
multiple interactions |
ISO |
[Atorvastatin co-treated with Enalapril] results in decreased expression of TRAF6 mRNA |
CTD |
PMID:20524934 |
|
NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
|
|
G |
Vcam1 |
vascular cell adhesion molecule 1 |
affects expression decreases expression |
ISO |
Enalapril affects the expression of VCAM1 Enalapril results in decreased expression of VCAM1 mRNA; Enalapril results in decreased expression of VCAM1 protein modified form |
CTD |
PMID:17347482 PMID:19939336 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions increases expression |
EXP ISO |
Enalapril inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein] Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [VEGFA protein results in increased expression of VEGFA mRNA] Enalapril results in increased expression of VEGFA protein |
CTD |
PMID:12110003 PMID:16202860 PMID:17299153 PMID:21263376 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
G |
Vwf |
von Willebrand factor |
decreases expression |
ISO |
Enalapril results in decreased expression of VWF mRNA |
CTD |
PMID:25037058 |
|
NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
|
|
|
G |
Ace |
angiotensin I converting enzyme |
multiple interactions |
ISO |
Enalaprilat inhibits the reaction [Glucose results in increased expression of ACE protein] |
CTD |
PMID:16452552 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
|
|
G |
Adrb1 |
adrenoceptor beta 1 |
affects expression |
EXP |
Enalaprilat affects the expression of ADRB1 protein |
CTD |
PMID:9260993 |
|
NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
|
|
G |
Adrb2 |
adrenoceptor beta 2 |
affects expression |
EXP |
Enalaprilat affects the expression of ADRB2 protein |
CTD |
PMID:9260993 |
|
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
|
|
G |
Agt |
angiotensinogen |
decreases expression multiple interactions |
EXP ISO |
Enalaprilat results in decreased expression of AGT protein modified form Enalaprilat inhibits the reaction [Glucose results in increased expression of AGT protein] |
CTD |
PMID:16452552 PMID:21795644 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
ISO |
Enalaprilat inhibits the reaction [Glucose results in increased expression of AGTR1 protein] |
CTD |
PMID:16452552 |
|
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
ISO |
Enalaprilat results in increased expression of BCL2 mRNA |
CTD |
PMID:17342403 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Bdkrb1 |
bradykinin receptor B1 |
multiple interactions increases activity |
ISO |
bradykinin, Lys-Leu(8)-desArg(9)- inhibits the reaction [Enalaprilat results in increased activity of BDKRB1 protein]; Zinc affects the reaction [Enalaprilat results in increased activity of BDKRB1 protein] |
CTD |
PMID:11880373 |
|
NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
|
|
G |
Edn1 |
endothelin 1 |
decreases secretion |
ISO |
Enalaprilat results in decreased secretion of EDN1 protein |
CTD |
PMID:19079593 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
|
|
G |
Fn1 |
fibronectin 1 |
decreases expression multiple interactions |
EXP ISO |
Enalaprilat results in decreased expression of FN1 mRNA; Enalaprilat results in decreased expression of FN1 protein Enalaprilat inhibits the reaction [Glucose results in increased expression of FN1 mRNA] |
CTD |
PMID:14520012 PMID:21795644 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
|
|
G |
Glud1 |
glutamate dehydrogenase 1 |
multiple interactions |
EXP |
Enalaprilat inhibits the reaction [Dexamethasone results in decreased expression of GLUD1 mRNA]; Enalaprilat inhibits the reaction [Dexamethasone results in decreased expression of GLUD2 mRNA] |
CTD |
PMID:32494933 |
|
NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
|
|
G |
Grm1 |
glutamate metabotropic receptor 1 |
multiple interactions |
EXP |
Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of GRM1 mRNA] |
CTD |
PMID:32494933 |
|
NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
|
|
G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
EXP |
Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 mRNA]; Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 protein] |
CTD |
PMID:32494933 |
|
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
|
|
G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
Enalaprilat inhibits the reaction [Glucose results in decreased secretion of INS protein] |
CTD |
PMID:16452552 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
|
|
G |
Ppard |
peroxisome proliferator-activated receptor delta |
multiple interactions |
EXP |
[Enalaprilat co-treated with Daunorubicin] results in increased expression of PPARD mRNA |
CTD |
PMID:23834779 |
|
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
|
|
G |
Ren |
renin |
increases expression |
EXP |
Enalaprilat results in increased expression of REN mRNA |
CTD |
PMID:21795644 |
|
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
|
|
G |
Serpine1 |
serpin family E member 1 |
decreases expression |
EXP |
Enalaprilat results in decreased expression of SERPINE1 mRNA |
CTD |
PMID:21795644 |
|
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
|
|
G |
Slc22a8 |
solute carrier family 22 member 8 |
multiple interactions increases uptake |
ISO |
verlukast inhibits the reaction [SLC22A8 protein results in increased uptake of Enalaprilat] |
CTD |
PMID:33007874 |
|
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression |
EXP |
Enalaprilat results in decreased expression of TGFB1 mRNA; Enalaprilat results in decreased expression of TGFB1 protein |
CTD |
PMID:21795644 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of TLR4 mRNA] |
CTD |
PMID:32494933 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
|
|
G |
Tnf |
tumor necrosis factor |
decreases expression |
ISO |
Enalaprilat results in decreased expression of TNF mRNA |
CTD |
PMID:17342403 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions affects localization |
ISO |
epoxomicin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein] epoxomicin affects the localization of AHR protein |
CTD |
PMID:17445780 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Atf4 |
activating transcription factor 4 |
multiple interactions |
ISO |
epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of ATF4 protein]] |
CTD |
PMID:25639565 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BAX protein]] |
CTD |
PMID:25639565 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of BCL2 protein]] |
CTD |
PMID:25639565 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
increases expression multiple interactions |
ISO |
epoxomicin results in increased expression of BIRC5 protein epoxomicin inhibits the reaction [Aspirin results in decreased expression of BIRC5 protein] |
CTD |
PMID:17510429 PMID:18483385 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased cleavage of and results in increased activity of CASP3 protein]] |
CTD |
PMID:25639565 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cdh1 |
cadherin 1 |
increases expression multiple interactions |
ISO |
epoxomicin results in increased expression of CDH1 protein NFE2L2 protein alternative form inhibits the reaction [epoxomicin results in increased expression of CDH1 protein] |
CTD |
PMID:35124418 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
|
|
G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
ISO |
epoxomicin inhibits the reaction [NSC606985 results in decreased expression of CEBPA protein] |
CTD |
PMID:19662097 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
|
|
G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
affects expression |
ISO |
epoxomicin affects the expression of CFLAR protein alternative form |
CTD |
PMID:17510429 |
|
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
|
|
G |
Dao |
D-amino-acid oxidase |
affects localization |
ISO |
epoxomicin affects the localization of DAO protein |
CTD |
PMID:28451739 |
|
NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741
|
|
G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2AK3 protein]] |
CTD |
PMID:25639565 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
|
|
G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions |
ISO |
epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2S1 protein]] |
CTD |
PMID:25639565 |
|
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
|
|
G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
ISO |
epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of ERN1 protein]] |
CTD |
PMID:25639565 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions increases expression |
ISO |
epoxomicin inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; epoxomicin inhibits the reaction [scutellarin results in decreased expression of HIF1A protein] epoxomicin results in increased expression of HIF1A protein |
CTD |
PMID:25192544 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
|
|
G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
epoxomicin results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
|
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
|
|
G |
Nfe2l1 |
NFE2 like bZIP transcription factor 1 |
multiple interactions increases expression |
ISO |
epoxomicin results in increased expression of and affects the localization of NFE2L1 protein; NFE2L1 protein affects the reaction [epoxomicin results in increased expression of PSMA2 mRNA]; NFE2L1 protein affects the reaction [epoxomicin results in increased expression of PSMB6 mRNA]; NFE2L1 protein affects the reaction [epoxomicin results in increased expression of PSMC4 mRNA] epoxomicin results in increased expression of NFE2L1 protein alternative form NFE2L1 alternative form affects the reaction [epoxomicin results in increased expression of NFE2L1 protein alternative form] |
CTD |
PMID:27345029 PMID:32980394 |
|
NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression multiple interactions |
ISO |
epoxomicin results in increased expression of NFE2L2 protein NFE2L2 protein alternative form inhibits the reaction [epoxomicin results in increased expression of CDH1 protein] |
CTD |
PMID:22558124 PMID:35124418 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Optn |
optineurin |
increases expression |
ISO EXP |
epoxomicin results in increased expression of OPTN protein |
CTD |
PMID:21059646 |
|
NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251
|
|
G |
Pacrg |
parkin coregulated |
decreases expression |
EXP ISO |
epoxomicin results in decreased expression of PACRG mRNA |
CTD |
PMID:18586549 |
|
NCBI chr 1:49,882,671...50,305,564
Ensembl chr 1:49,882,630...50,305,430
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [epoxomicin results in increased cleavage of PARP1 protein] |
CTD |
PMID:20153345 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Pdyn |
prodynorphin |
multiple interactions decreases expression |
ISO EXP |
epoxomicin inhibits the reaction [Potassium results in increased secretion of PDYN protein alternative form]; epoxomicin results in decreased expression of and results in decreased secretion of PDYN protein alternative form epoxomicin results in decreased expression of PDYN protein alternative form |
CTD |
PMID:17670969 |
|
NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
epoxomicin inhibits the reaction [resveratrol results in decreased expression of PPARG protein]; epoxomicin inhibits the reaction [rosiglitazone results in decreased expression of PPARG protein] |
CTD |
PMID:18555852 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
decreases expression multiple interactions |
ISO EXP |
epoxomicin results in decreased expression of PRKN mRNA epoxomicin inhibits the reaction [PRKN protein results in decreased susceptibility to Ceramides] |
CTD |
PMID:12588799 PMID:18586549 |
|
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
|
|
G |
Psma2 |
proteasome 20S subunit alpha 2 |
multiple interactions increases expression |
ISO |
NFE2L1 protein affects the reaction [epoxomicin results in increased expression of PSMA2 mRNA] |
CTD |
PMID:27345029 |
|
NCBI chr17:50,554,536...50,564,923
Ensembl chr17:50,551,924...50,564,938
|
|
G |
Psmb6 |
proteasome 20S subunit beta 6 |
increases expression multiple interactions |
ISO |
epoxomicin results in increased expression of PSMB6 mRNA Ascorbic Acid inhibits the reaction [epoxomicin results in increased expression of PSMB6 mRNA]; NFE2L1 protein affects the reaction [epoxomicin results in increased expression of PSMB6 mRNA]; sulforaphane inhibits the reaction [epoxomicin results in increased expression of PSMB6 mRNA] |
CTD |
PMID:27345029 |
|
NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586
|
|
G |
Psmc4 |
proteasome 26S subunit, ATPase 4 |
multiple interactions increases expression |
ISO |
NFE2L1 protein affects the reaction [epoxomicin results in increased expression of PSMC4 mRNA] |
CTD |
PMID:27345029 |
|
NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494
|
|
G |
Sp1 |
Sp1 transcription factor |
multiple interactions increases ubiquitination |
ISO |
epoxomicin inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of SP1 protein]; epoxomicin inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in increased degradation of SP1 protein] epoxomicin results in increased ubiquitination of SP1 protein |
CTD |
PMID:17409431 |
|
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
|
|
G |
Taf1 |
TATA-box binding protein associated factor 1 |
multiple interactions |
ISO |
epoxomicin inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of TAF1 protein] |
CTD |
PMID:17409431 |
|
NCBI chr X:66,640,915...66,716,543
Ensembl chr X:66,640,982...66,716,543
|
|
G |
Tardbp |
TAR DNA binding protein |
multiple interactions |
ISO |
epoxomicin inhibits the reaction [Cycloheximide results in decreased expression of and results in decreased stability of TARDBP protein mutant form]; epoxomicin inhibits the reaction [Cycloheximide results in decreased expression of TARDBP protein] |
CTD |
PMID:24477737 |
|
NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
|
|
|
G |
Gsta4 |
glutathione S-transferase alpha 4 |
multiple interactions |
EXP |
GSTA4 protein binds to and affects the metabolism of gamma-glutamyl-glutathione |
CTD |
PMID:2619714 |
|
NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
EXP |
GSTP1 protein binds to and affects the metabolism of gamma-glutamyl-glutathione |
CTD |
PMID:2619714 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
|
|
|
G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions |
ISO |
Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BIRC3 mRNA] |
CTD |
PMID:14527959 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
EXP |
Gliotoxin results in increased cleavage of and results in increased activity of CASP3 protein; Mercuric Chloride inhibits the reaction [Gliotoxin results in increased activity of CASP3 protein] |
CTD |
PMID:17466404 PMID:20958918 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cyp2b2 |
cytochrome P450, family 2, subfamily b, polypeptide 2 |
decreases expression |
EXP |
Gliotoxin results in decreased expression of CYP2B2 mRNA |
CTD |
PMID:18346771 |
|
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
|
|
G |
Decr2 |
2,4-dienoyl-CoA reductase 2 |
decreases expression |
EXP |
Gliotoxin results in decreased expression of DECR2 mRNA |
CTD |
PMID:18346771 |
|
NCBI chr10:15,104,907...15,113,281
Ensembl chr10:15,002,926...15,118,479
|
|
G |
Dnajb1 |
DnaJ heat shock protein family (Hsp40) member B1 |
increases expression |
EXP |
Gliotoxin results in increased expression of DNAJB1 mRNA |
CTD |
PMID:18346771 |
|
NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458
|
|
G |
Dpys |
dihydropyrimidinase |
decreases expression |
EXP |
Gliotoxin results in decreased expression of DPYS mRNA |
CTD |
PMID:18346771 |
|
NCBI chr 7:70,822,648...70,929,255
Ensembl chr 7:70,835,789...70,929,231
|
|
G |
Ech1 |
enoyl-CoA hydratase 1 |
decreases expression |
EXP |
Gliotoxin results in decreased expression of ECH1 mRNA |
CTD |
PMID:18346771 |
|
NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
|
|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
EXP |
Gliotoxin results in increased expression of GADD45A mRNA |
CTD |
PMID:18346771 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
|
|
G |
Gjb1 |
gap junction protein, beta 1 |
decreases expression |
EXP |
Gliotoxin results in decreased expression of GJB1 mRNA |
CTD |
PMID:18346771 |
|
NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925
|
|
G |
Gnmt |
glycine N-methyltransferase |
decreases expression |
EXP |
Gliotoxin results in decreased expression of GNMT mRNA |
CTD |
PMID:18346771 |
|
NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
|
|
G |
Gstm2 |
glutathione S-transferase mu 2 |
decreases expression |
EXP |
Gliotoxin results in decreased expression of GSTM2 mRNA |
CTD |
PMID:18346771 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
|
|
G |
Hal |
histidine ammonia lyase |
decreases expression |
EXP |
Gliotoxin results in decreased expression of HAL mRNA |
CTD |
PMID:18346771 |
|
NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
decreases expression |
ISO |
Gliotoxin results in decreased expression of HIF1A mRNA |
CTD |
PMID:20432243 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
|
|
G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
Gliotoxin inhibits the reaction [Acetaminophen results in increased activity of HRAS protein] |
CTD |
PMID:19739265 |
|
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
|
|
G |
Ifng |
interferon gamma |
decreases expression decreases secretion |
ISO |
Gliotoxin results in decreased expression of IFNG mRNA Gliotoxin results in decreased secretion of IFNG protein |
CTD |
PMID:12112629 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G |
Ifrd1 |
interferon-related developmental regulator 1 |
increases expression |
EXP |
Gliotoxin results in increased expression of IFRD1 mRNA |
CTD |
PMID:18346771 |
|
NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
|
|
G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Gliotoxin results in increased expression of JUNB mRNA |
CTD |
PMID:18346771 |
|
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK1 protein |
CTD |
PMID:17466404 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK3 protein |
CTD |
PMID:17466404 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
Gliotoxin results in increased phosphorylation of and results in increased activity of MAPK8 protein |
CTD |
PMID:17466404 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mbl1 |
mannose binding lectin 1 |
decreases expression |
EXP |
Gliotoxin results in decreased expression of MBL1 mRNA |
CTD |
PMID:18346771 |
|
NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:14527959 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
|
|
G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
increases expression |
EXP |
Gliotoxin results in increased expression of PPP1R15A mRNA |
CTD |
PMID:18346771 |
|
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:14527959 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
Gliotoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SOD2 mRNA] |
CTD |
PMID:10653605 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sult1b1 |
sulfotransferase family 1B member 1 |
decreases expression |
EXP |
Gliotoxin results in decreased expression of SULT1B1 mRNA |
CTD |
PMID:18346771 |
|
NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Gliotoxin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] |
CTD |
PMID:10653605 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Ttpa |
alpha tocopherol transfer protein |
decreases expression |
EXP |
Gliotoxin results in decreased expression of TTPA mRNA |
CTD |
PMID:18346771 |
|
NCBI chr 5:33,497,537...33,518,936
Ensembl chr 5:33,497,137...33,518,073
|
|
G |
Upb1 |
beta-ureidopropionase 1 |
decreases expression |
EXP |
Gliotoxin results in decreased expression of UPB1 mRNA |
CTD |
PMID:18346771 |
|
NCBI chr20:13,217,252...13,243,590
Ensembl chr20:13,217,258...13,243,590
|
|
|
G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions increases expression |
ISO |
Glutathione promotes the reaction [Quercetin results in increased expression of ABCA1 mRNA]; Quercetin promotes the reaction [Glutathione results in increased expression of ABCA1 mRNA] |
CTD |
PMID:25204422 |
|
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
|
|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Glutathione inhibits the reaction [Ethanol results in increased expression of ABCB1 mRNA]; Glutathione inhibits the reaction [Hydrogen Peroxide affects the expression of ABCB1 mRNA]; Glutathione inhibits the reaction [titanium dioxide results in increased expression of ABCB1 mRNA] |
CTD |
PMID:33766574 PMID:35478211 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
|
|
G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
affects export |
ISO |
ABCB4 protein affects the export of Glutathione |
CTD |
PMID:11302927 |
|
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
|
|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
affects export increases uptake multiple interactions increases export affects transport |
ISO EXP |
ABCC1 protein affects the export of Glutathione ABCC1 protein results in increased uptake of Glutathione [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to arsenite]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to monomethylarsonous acid analog]; [Glutathione binds to 10-nitro-oleic acid] promotes the reaction [ABCC1 protein results in increased export of 10-nitro-oleic acid metabolite]; [Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; [Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; ABCC1 protein affects the reaction [chrysin results in increased transport of Glutathione]; ABCC1 protein affects the transport of [arsenite co-treated with Glutathione]; Apigenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]; estradiol-17 beta-glucuronide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]]; Genistein promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Glutathione affects the reaction [ABCC1 protein results in increased secretion of Antimony Potassium Tartrate]; Glutathione affects the reaction [ABCC1 protein results in increased secretion of Arsenic Trioxide]; Glutathione binds to and affects the folding of and affects the activity of ABCC1 protein; Glutathione Disulfide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; Glutathione inhibits the reaction [titanium dioxide results in increased expression of ABCC1 mRNA]; Glutathione promotes the reaction [ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog]; Glutathione promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]; Glutathione promotes the reaction [Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [Genistein affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin results in increased activity of ABCC1 protein]; Glutathione results in increased stability of and results in decreased degradation of and affects the localization of ABCC1 protein mutant form; naringenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; PAK 104P promotes the reaction [ABCC1 protein affects the export of Glutathione]; Quercetin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Verapamil promotes the reaction [ABCC1 protein affects the export of Glutathione]; Verapamil promotes the reaction [ABCC1 protein affects the transport of Glutathione]; Verapamil promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Vincristine inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]] [verlukast results in decreased activity of ABCC1 protein] inhibits the reaction [Arsenates results in increased export of Glutathione] ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione]; ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Glutathione]; buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione] ABCC1 protein affects the transport of Glutathione; ABCC1 protein affects the transport of Glutathione analog |
CTD |
PMID:11278867 PMID:11306701 PMID:12018890 PMID:12485947 PMID:12504668 PMID:15161912 PMID:15245331 PMID:15498506 PMID:15561710 PMID:15579473 PMID:15581632 PMID:15766272 PMID:16679408 PMID:17272743 PMID:20584751 PMID:21856323 PMID:21918036 PMID:23542460 PMID:29158255 PMID:33766574 More...
|
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions affects abundance affects transport |
ISO EXP |
ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione]; Glutathione promotes the reaction [ABCC2 protein affects the export of phenethyl isothiocyanate] ABCC2 protein affects the abundance of Glutathione ABCC2 protein affects the transport of Glutathione ABCC2 protein affects the transport of Glutathione analog |
CTD |
PMID:16002050 PMID:16049127 PMID:16611851 PMID:20584751 PMID:25450747 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
|
|
G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
ABCC3 protein affects the reaction [chrysin results in increased transport of Glutathione]; Glutathione promotes the reaction [ABCC3 protein affects the transport of calcein AM] |
CTD |
PMID:15210835 PMID:21856323 |
|
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
|
|
G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions affects transport |
ISO |
ABCC4 protein results in increased export of [2,6-dibromobenzoquinone binds to Glutathione]; ABCC4 protein results in increased export of [2,6-dichloro-(1,4)benzoquinone binds to Glutathione]; Glutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM] ABCC4 protein affects the transport of Glutathione analog |
CTD |
PMID:15210835 PMID:20584751 PMID:28885828 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
|
|
G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
multiple interactions affects transport |
ISO |
ABCC5 protein affects the reaction [chrysin results in increased transport of Glutathione] ABCC5 protein affects the transport of Glutathione analog |
CTD |
PMID:20584751 PMID:21856323 |
|
NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
|
|
G |
Abcc6 |
ATP binding cassette subfamily C member 6 |
multiple interactions |
ISO |
Glutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM] |
CTD |
PMID:15210835 |
|
NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
|
|
G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions increases export |
ISO |
2',5'-dihydroxychalcone promotes the reaction [ABCG2 protein results in increased export of Glutathione]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of Glutathione] |
CTD |
PMID:20332504 |
|
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
|
|
G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein] |
CTD |
PMID:20100039 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
|
|
G |
Acox1 |
acyl-CoA oxidase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ACOX1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
|
|
G |
Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ACSL4 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
|
|
G |
Adh5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
multiple interactions |
ISO |
Glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] |
CTD |
PMID:19428350 |
|
NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
|
|
G |
Agt |
angiotensinogen |
multiple interactions decreases abundance |
ISO |
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione]; AGT protein promotes the reaction [GSR protein affects the chemical synthesis of Glutathione]; FNDC5 protein inhibits the reaction [AGT protein modified form results in decreased abundance of Glutathione] AGT protein modified form results in increased chemical synthesis of [4-oxo-2-nonenal binds to Glutathione] AGT protein modified form results in decreased abundance of Glutathione; AGT protein results in decreased abundance of Glutathione |
CTD |
PMID:17272743 PMID:30703374 PMID:31144504 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased abundance of Glutathione] |
CTD |
PMID:12398935 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
AIFM1 protein inhibits the reaction [arsenic acid results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [Nitroprusside results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [Paraquat results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Glutathione] |
CTD |
PMID:15316071 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
|
|
G |
Akap1 |
A-kinase anchoring protein 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of AKAP1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr10:73,621,021...73,654,123
Ensembl chr10:73,621,883...73,653,896
|
|
G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases glutathionylation increases reduction affects binding |
ISO |
Glutathione results in increased glutathionylation of AKR1B1 protein modified form Glutathione results in increased reduction of AKR1B1 protein modified form AKR1B1 protein binds to Glutathione |
CTD |
PMID:11306073 PMID:19061876 |
|
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
|
|
G |
Akr1d1 |
aldo-keto reductase family 1, member D1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of AKR1D1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
|
|
G |
Akr7a2 |
aldo-keto reductase family 7, member A2 |
increases expression multiple interactions |
EXP ISO |
Glutathione deficiency results in increased expression of AKR7A2 mRNA AKR7A2 protein inhibits the reaction [Vitamin K 3 results in decreased abundance of Glutathione] |
CTD |
PMID:15345336 PMID:22001351 |
|
NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
|
|
G |
Akr7a3 |
aldo-keto reductase family 7 member A3 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of AKR7A3 mRNA |
CTD |
PMID:15345336 PMID:20621112 |
|
NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:17640567 PMID:24015256 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Alad |
aminolevulinate dehydratase |
multiple interactions |
EXP |
Glutathione inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein] |
CTD |
PMID:21620807 |
|
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
|
|
G |
Alb |
albumin |
multiple interactions |
ISO |
[4,4'-diphenylmethane diisocyanate co-treated with Glutathione] binds to and results in increased metabolism of ALB protein |
CTD |
PMID:23791970 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
|
|
G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
|
|
G |
Ap2m1 |
adaptor related protein complex 2 subunit mu 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of AP2M1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
|
|
G |
Aplp2 |
amyloid beta precursor like protein 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of APLP2 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855
|
|
G |
Apoa1 |
apolipoprotein A1 |
multiple interactions |
ISO |
[Glutathione co-treated with Quercetin] promotes the reaction [APOA1 protein results in increased export of Cholesterol] |
CTD |
PMID:25204422 |
|
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
|
|
G |
Apoe |
apolipoprotein E |
decreases abundance multiple interactions |
ISO |
APOE gene mutant form results in decreased abundance of Glutathione notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased abundance of Glutathione] |
CTD |
PMID:24933211 |
|
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
|
|
G |
Apol9a-Apol7a |
Apol9a-Apol7a readthrough |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of APOL7B mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 7:109,118,559...109,149,798
Ensembl chr 7:109,131,064...109,147,649
|
|
G |
App |
amyloid beta precursor protein |
decreases abundance multiple interactions |
EXP ISO |
APP protein modified form results in decreased abundance of Glutathione vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione] resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione] |
CTD |
PMID:25654502 PMID:29545167 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G |
As3mt |
arsenite methyltransferase |
multiple interactions affects folding |
EXP ISO |
Glutathione affects the reaction [AS3MT protein affects the metabolism of arsenic acid]; Glutathione affects the reaction [AS3MT protein affects the metabolism of arsenous acid]; Glutathione affects the reaction [AS3MT protein affects the metabolism of dimethylarsine]; Glutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine oxide]; Glutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine] Glutathione affects the folding of AS3MT protein Glutathione promotes the reaction [[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid]; Glutathione promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]; Glutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite]; Glutathione promotes the reaction [AS3MT protein results in increased methylation of arsenite]; Glutathione results in increased reduction of and affects the folding of AS3MT protein |
CTD |
PMID:15606138 PMID:22868225 PMID:22955273 PMID:25349987 |
|
NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872
|
|
G |
Atf4 |
activating transcription factor 4 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of ATF4 protein]; Glutathione inhibits the reaction [Camptothecin results in increased expression of ATF4 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of ATF4 protein] |
CTD |
PMID:24515801 PMID:30266318 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
|
|
G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
ISO |
SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of ATF6 protein modified form] |
CTD |
PMID:27349771 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
|
|
G |
Atg5 |
autophagy related 5 |
multiple interactions affects abundance |
ISO |
[ATG5 gene mutant form results in increased activity of NFE2L2 protein] affects the reaction [Acetaminophen affects the abundance of Glutathione]; [ATG5 gene mutant form results in increased activity of NFE2L2 protein] which affects the abundance of Glutathione; ATG5 protein affects the reaction [Acetaminophen affects the abundance of Glutathione] ATG5 protein affects the abundance of Glutathione |
CTD |
PMID:22491424 |
|
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
|
|
G |
Atg7 |
autophagy related 7 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Apigenin results in increased expression of ATG7 protein] |
CTD |
PMID:29247770 |
|
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
|
|
G |
Atp1b1 |
ATPase Na+/K+ transporting subunit beta 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ATP1B1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
|
|
G |
Atp7b |
ATPase copper transporting beta |
decreases abundance multiple interactions |
ISO |
ATP7B gene mutant form results in decreased abundance of Glutathione Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione]; Zinc Sulfate inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione] |
CTD |
PMID:24368744 |
|
NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
Glutathione results in increased expression of BAX protein Glutathione inhibits the reaction [Acrolein results in increased expression of BAX protein] [[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein; Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of BAX protein]; Glutathione inhibits the reaction [Ivermectin results in increased expression of BAX protein] |
CTD |
PMID:10897038 PMID:21621595 PMID:24036456 PMID:24376112 PMID:34904774 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases export |
ISO |
Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in decreased expression of BCL2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; Glutathione inhibits the reaction [Ivermectin results in decreased expression of BCL2 protein] [diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA; Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 protein]; Glutathione inhibits the reaction [Acrolein results in decreased expression of BCL2 protein] BCL2 protein results in decreased export of Glutathione |
CTD |
PMID:15561710 PMID:17640567 PMID:22564015 PMID:24036456 PMID:24376112 PMID:34904774 PMID:36689145 More...
|
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]] |
CTD |
PMID:17640567 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
|
|
G |
Bcl3 |
BCL3, transcription coactivator |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of BCL3 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
|
|
G |
Bdh2 |
3-hydroxybutyrate dehydrogenase 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of BDH2 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072
|
|
G |
Bgn |
biglycan |
multiple interactions |
ISO |
[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in increased chemical synthesis of Glutathione |
CTD |
PMID:35234341 |
|
NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461
|
|
G |
Birc2 |
baculoviral IAP repeat-containing 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]] |
CTD |
PMID:17640567 |
|
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
|
|
G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Thimerosal results in decreased expression of BIRC3 protein] |
CTD |
PMID:12140745 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
|
|
G |
Bmi1 |
BMI1 proto-oncogene, polycomb ring finger |
increases abundance |
ISO |
BMI1 protein results in increased abundance of Glutathione |
CTD |
PMID:21445297 |
|
NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690
|
|
G |
Bnip3 |
BCL2 interacting protein 3 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein] |
CTD |
PMID:19442826 |
|
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
|
|
G |
Bst2 |
bone marrow stromal cell antigen 2 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of BST2 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979
|
|
G |
C5 |
complement C5 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of C5 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO EXP |
[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which results in increased activity of CASP3 protein; Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of CASP3 protein]; Glutathione inhibits the reaction [aristolochic acid I results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [Diquat results in increased cleavage of CASP3 protein]; Glutathione inhibits the reaction [Thimerosal results in increased activity of CASP3 protein] Glutathione results in increased activity of CASP3 protein Glutathione inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [JP8 aviation fuel results in increased activity of CASP3 protein] Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP3 protein]; Glutathione inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]; Glutathione inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP3 protein]; Glutathione promotes the reaction [FAS protein results in increased activity of CASP3 protein] |
CTD |
PMID:10385654 PMID:11969376 PMID:12140745 PMID:14660655 PMID:15683462 PMID:17640567 PMID:21300145 PMID:21621595 PMID:24036456 PMID:24376112 PMID:33309544 PMID:36689145 PMID:38128689 More...
|
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp6 |
caspase 6 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CASP6 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
|
|
G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of CASP7 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP7 protein] |
CTD |
PMID:24515801 |
|
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
|
|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Acrolein results in increased expression of CASP8 protein] Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of CASP8 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP8 protein] |
CTD |
PMID:24376112 PMID:24515801 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
Glutathione affects the reaction [SOD2 protein affects the activity of CASP9 protein]; Glutathione inhibits the reaction [Thimerosal results in increased activity of CASP9 protein] Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased cleavage of CASP9 protein]; Glutathione inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP9 protein] |
CTD |
PMID:12140745 PMID:18594523 PMID:33309544 PMID:36689145 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cat |
catalase |
multiple interactions decreases response to substance |
ISO EXP |
[INS1 protein co-treated with Glutathione] affects the activity of CAT protein; [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of CAT mRNA; CAT inhibits the reaction [Buthionine Sulfoximine results in decreased abundance of Glutathione]; CAT protein inhibits the reaction [casiopeina II results in decreased abundance of Glutathione] CAT protein results in decreased susceptibility to Glutathione Glutathione inhibits the reaction [diphenyldiselenide results in decreased activity of CAT protein]; Glutathione inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Glutathione inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein] |
CTD |
PMID:19419996 PMID:20580664 PMID:21354300 PMID:21620807 PMID:25362599 PMID:26187465 PMID:27718046 More...
|
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Cav2 |
caveolin 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CAV2 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244
|
|
G |
Cbr3 |
carbonyl reductase 3 |
multiple interactions |
ISO |
[GCLM gene mutant form results in decreased abundance of Glutathione] which results in increased expression of CBR3 protein |
CTD |
PMID:25446851 |
|
NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
|
|
G |
Cbs |
cystathionine beta synthase |
decreases abundance |
ISO |
CBS gene mutant form results in decreased abundance of Glutathione |
CTD |
PMID:15016621 |
|
NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [[Particulate Matter analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL2 protein]; Glutathione inhibits the reaction [[Vehicle Emissions analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL2 protein] |
CTD |
PMID:10919993 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Ccl20 |
C-C motif chemokine ligand 20 |
decreases expression |
ISO |
Glutathione results in decreased expression of CCL20 mRNA |
CTD |
PMID:22385246 |
|
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
|
|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [[Particulate Matter analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [[Vehicle Emissions analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Particulate Matter analog results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Vehicle Emissions analog results in increased secretion of CCL5 protein] |
CTD |
PMID:10919993 |
|
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
|
|
G |
Ccna2 |
cyclin A2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [rubimaillin results in decreased expression of CCNA2 protein] |
CTD |
PMID:35007525 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
|
|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]] |
CTD |
PMID:17640567 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Cd14 |
CD14 molecule |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CD14 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
|
|
G |
Cd36 |
CD36 molecule |
multiple interactions decreases expression |
ISO |
[GCLC mRNA results in increased abundance of Glutathione] which results in decreased expression of CD36 protein Glutathione results in decreased expression of CD36 protein |
CTD |
PMID:26187465 |
|
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
|
|
G |
Cd40lg |
CD40 ligand |
multiple interactions |
ISO |
Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein] |
CTD |
PMID:27634759 |
|
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
|
|
G |
Cd86 |
CD86 molecule |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Glutathione inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]; Glutathione inhibits the reaction [Thimerosal results in increased expression of CD86 protein] |
CTD |
PMID:20457211 |
|
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
|
|
G |
Cdc25b |
cell division cycle 25B |
multiple interactions |
ISO |
[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate |
CTD |
PMID:20025242 |
|
NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
|
|
G |
Cdc25c |
cell division cycle 25C |
multiple interactions |
ISO |
[CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate |
CTD |
PMID:20025242 |
|
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
|
|
G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [rubimaillin results in decreased expression of CDK2 protein] |
CTD |
PMID:35007525 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
|
|
G |
Cdk4 |
cyclin-dependent kinase 4 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CDK4 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein] |
CTD |
PMID:22927544 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cdo1 |
cysteine dioxygenase type 1 |
increases abundance |
EXP |
CDO1 protein results in increased abundance of Glutathione |
CTD |
PMID:23665415 |
|
NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296
|
|
G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions |
ISO |
Glutathione inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA] |
CTD |
PMID:21220312 |
|
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
|
|
G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions affects export decreases activity |
ISO |
[Bicarbonates co-treated with Glutathione co-treated with Ascorbic Acid] results in increased activity of CFTR protein; [Glutathione co-treated with Diamide] results in decreased activity of CFTR protein; Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein]; Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CFTR protein affects the export of Glutathione Glutathione analog results in decreased activity of CFTR protein |
CTD |
PMID:15561710 PMID:15657297 PMID:15857825 PMID:32374624 |
|
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
|
|
G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]] |
CTD |
PMID:17067557 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
|
|
G |
Cldn4 |
claudin 4 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] |
CTD |
PMID:23816505 |
|
NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
|
|
G |
Clu |
clusterin |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CLU mRNA |
CTD |
PMID:15345336 |
|
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
|
|
G |
Cntf |
ciliary neurotrophic factor |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]] |
CTD |
PMID:16896058 |
|
NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877
|
|
G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CPT1A mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
|
|
G |
Creg1 |
cellular repressor of E1A-stimulated genes 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CREG1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308
|
|
G |
Cryab |
crystallin, alpha B |
multiple interactions |
EXP |
Glutathione inhibits the reaction [arsenite results in increased expression of CRYAB protein] |
CTD |
PMID:15175009 |
|
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
|
|
G |
Ctps1 |
CTP synthase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of CTPS1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180
|
|
G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of CXCL1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
|
|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
Glutathione deficiency promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of CXCL1 protein] |
CTD |
PMID:26149495 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
|
|
G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of CYCS protein |
CTD |
PMID:21621595 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of CYP1A1 mRNA; Glutathione affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Glutathione affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA] [CYP1A1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1A1 protein results in increased susceptibility to 4,4'-hexafluorisopropylidene diphenol] which results in increased abundance of Glutathione |
CTD |
PMID:18078826 PMID:21094198 PMID:24246759 PMID:35395335 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[CYP1A2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; [CYP1A2 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP1A2 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [myristicin results in decreased activity of CYP1A2 protein] |
CTD |
PMID:20825217 PMID:24246759 PMID:26091900 PMID:31102647 PMID:32198085 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
[CYP1B1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; CYP1B1 protein affects the metabolism of [2-hydroxyestradiol co-treated with Glutathione]; CYP1B1 protein affects the metabolism of [4-hydroxyestradiol co-treated with Glutathione] |
CTD |
PMID:14679015 PMID:24246759 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G |
Cyp2a2 |
cytochrome P450, family 2, subfamily a, polypeptide 2 |
multiple interactions |
EXP |
[CYP2A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine |
CTD |
PMID:20825217 |
|
NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487
|
|
G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions |
ISO |
[CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2B6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] |
CTD |
PMID:24246759 PMID:32198085 |
|
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
|
|
G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions |
ISO |
[CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac |
CTD |
PMID:24246759 |
|
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
|
|
G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions |
ISO |
[CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP2C19 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] |
CTD |
PMID:24246759 PMID:31102647 PMID:32198085 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
|
|
G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
multiple interactions |
ISO |
[CYP2C8 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac |
CTD |
PMID:24246759 |
|
|
|
G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
ISO |
[[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; [CYP2D6 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP2D6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein] |
CTD |
PMID:20825217 PMID:24246759 PMID:31102647 PMID:32198085 |
|
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO EXP |
[CYP2E1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2E1 protein results in increased metabolism of Ethanol] which results in decreased abundance of Glutathione; [CYP2E1 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene] Glutathione inhibits the reaction [Alcohols results in increased expression of CYP2E1 protein] 1-phenylimidazole inhibits the reaction [[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde]; [[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde; [Glutathione co-treated with [CYP2E1 protein results in increased metabolism of Phenol]] results in increased chemical synthesis of [Glutathione binds to hydroquinone metabolite] |
CTD |
PMID:8211999 PMID:10573527 PMID:16872732 PMID:21842885 PMID:24246759 PMID:28803762 PMID:32198085 More...
|
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Cyp2j4 |
cytochrome P450, family 2, subfamily j, polypeptide 4 |
multiple interactions |
ISO |
[CYP2J2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac |
CTD |
PMID:24246759 |
|
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions affects binding |
EXP ISO |
[CYP3A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; [CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione; [CYP3A4 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP3A4 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Acetylcysteine inhibits the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]; Buthionine Sulfoximine promotes the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]; CYP3A4 protein promotes the reaction [Acetaminophen results in decreased abundance of Glutathione]; Glutathione affects the reaction [CYP3A4 protein binds to 1-pyrenebutanol]; Glutathione affects the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Glutathione affects the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxyquinoline]; Glutathione inhibits the reaction [Saquinavir results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; neferine promotes the reaction [[CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione] Glutathione binds to CYP3A4 protein |
CTD |
PMID:15523003 PMID:18206979 PMID:20825217 PMID:24246759 PMID:25451576 PMID:27485346 PMID:31102647 PMID:32198085 More...
|
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
|
|
G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions |
EXP |
[CYP3A23-3A1 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine |
CTD |
PMID:20825217 |
|
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
|
|
G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions |
ISO |
[CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; CYP3A5 protein promotes the reaction [tetrandrine results in decreased abundance of Glutathione] |
CTD |
PMID:24246759 PMID:26302866 |
|
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
|
|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of DDIT3 protein] Glutathione inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein] |
CTD |
PMID:17171638 PMID:20493918 PMID:24515801 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
|
|
G |
Decr1 |
2,4-dienoyl-CoA reductase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of DECR1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
|
|
G |
Decr2 |
2,4-dienoyl-CoA reductase 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of DECR2 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr10:15,104,907...15,113,281
Ensembl chr10:15,002,926...15,118,479
|
|
G |
Defb5 |
defensin beta 5 |
decreases expression |
ISO |
Glutathione results in decreased expression of DEFB4A mRNA |
CTD |
PMID:22385246 |
|
NCBI chr16:70,612,985...70,615,389
Ensembl chr16:70,613,146...70,615,467
|
|
G |
Dek |
DEK proto-oncogene |
decreases chemical synthesis |
ISO |
DEK protein results in decreased chemical synthesis of Glutathione |
CTD |
PMID:28558019 |
|
NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
|
|
G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Alcohols results in increased expression of DGAT1 protein] |
CTD |
PMID:28803762 |
|
NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
|
|
G |
Diablo |
diablo, IAP-binding mitochondrial protein |
multiple interactions |
ISO |
Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of DIABLO mRNA]; Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of DIABLO protein] |
CTD |
PMID:36689145 |
|
NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
|
|
G |
Dio1 |
iodothyronine deiodinase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of DIO1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
|
|
G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Particulate Matter results in decreased expression of DLG4 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein] |
CTD |
PMID:27624276 PMID:28153600 |
|
NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
|
|
G |
Dusp1 |
dual specificity phosphatase 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Cadmium results in increased expression of DUSP1 mRNA]; Glutathione inhibits the reaction [Cadmium results in increased expression of DUSP1 protein] |
CTD |
PMID:18573614 |
|
NCBI chr10:16,680,478...16,683,275
|
|
G |
Egf |
epidermal growth factor |
affects abundance |
EXP |
EGF protein affects the abundance of Glutathione |
CTD |
PMID:10544272 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
|
|
G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased phosphorylation of EGFR protein] [Acetaminophen results in decreased abundance of Glutathione] which results in increased phosphorylation of and results in increased activity of EGFR protein; [phorone results in decreased abundance of Glutathione] which results in increased phosphorylation of and results in increased activity of EGFR protein |
CTD |
PMID:14660655 PMID:28123000 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
|
|
G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of EIF2AK2 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
|
|
G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the phosphorylation of EIF2AK3 protein] |
CTD |
PMID:24515801 PMID:30266318 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
|
|
G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:30266318 |
|
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
|
|
G |
Epas1 |
endothelial PAS domain protein 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; Glutathione inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] |
CTD |
PMID:23958427 |
|
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
|
|
G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of EPHX1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
|
|
G |
Epo |
erythropoietin |
multiple interactions |
EXP ISO |
EPO protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione] EPO protein inhibits the reaction [Cisplatin results in decreased abundance of Glutathione] |
CTD |
PMID:16405037 PMID:22013135 |
|
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
|
|
G |
Extl1 |
exostosin-like glycosyltransferase 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of EXTL1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 5:146,573,911...146,589,115
Ensembl chr 5:146,573,912...146,589,115
|
|
G |
F3 |
coagulation factor III, tissue factor |
increases activity |
ISO |
Glutathione results in increased activity of F3 protein |
CTD |
PMID:17726162 |
|
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
|
|
G |
Fahd1 |
fumarylacetoacetate hydrolase domain containing 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of FAHD1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr10:13,873,539...13,874,978
Ensembl chr10:13,873,527...13,875,012
|
|
G |
Fas |
Fas cell surface death receptor |
multiple interactions affects chemical synthesis |
ISO |
[FAS protein results in increased expression of GCLC mRNA] which results in increased chemical synthesis of Glutathione; [FAS protein results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; FAS protein affects the reaction [Acetaminophen affects the chemical synthesis of Glutathione]; Glutathione promotes the reaction [FAS protein results in increased activity of CASP3 protein] FAS protein affects the chemical synthesis of Glutathione |
CTD |
PMID:10385654 PMID:23628456 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
|
|
G |
Faslg |
Fas ligand |
decreases abundance multiple interactions |
ISO |
FASL protein results in decreased abundance of Glutathione Glutathione inhibits the reaction [Acrolein results in increased expression of FASL protein] verlukast promotes the reaction [FASL protein results in decreased abundance of Glutathione] |
CTD |
PMID:17724027 PMID:24376112 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
|
|
G |
Fasn |
fatty acid synthase |
decreases expression multiple interactions |
EXP ISO |
Glutathione deficiency results in decreased expression of FASN mRNA Glutathione inhibits the reaction [Alcohols results in increased expression of FASN protein] |
CTD |
PMID:20621112 PMID:28803762 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
|
|
G |
Fgf1 |
fibroblast growth factor 1 |
multiple interactions |
EXP |
2-tert-butylhydroquinone promotes the reaction [FGF1 protein results in increased abundance of and results in increased secretion of Glutathione]; FGF1 protein results in increased abundance of and results in increased secretion of Glutathione |
CTD |
PMID:16524372 |
|
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
|
|
G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA] |
CTD |
PMID:19524604 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
|
|
G |
Fndc5 |
fibronectin type III domain containing 5 |
multiple interactions increases abundance |
ISO EXP |
FNDC5 protein inhibits the reaction [AGT protein modified form results in decreased abundance of Glutathione] FNDC5 protein results in increased abundance of Glutathione |
CTD |
PMID:30703374 PMID:32165127 |
|
NCBI chr 5:141,481,593...141,491,257
Ensembl chr 5:141,481,590...141,490,731
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Glutathione affects the reaction [Sodium Selenite results in increased expression of FOS mRNA]; Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Glutathione inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA] |
CTD |
PMID:15105052 PMID:15520183 PMID:18449455 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA] |
CTD |
PMID:15520183 |
|
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
|
|
G |
Foxa2 |
forkhead box A2 |
multiple interactions |
ISO |
Glutathione affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of FOXA2 mRNA]; Glutathione affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of FOXA2 protein] |
CTD |
PMID:36689145 |
|
NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
|
|
G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
EXP |
Glutathione inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein] |
CTD |
PMID:20580664 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
|
|
G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of FTH1 mRNA] |
CTD |
PMID:16631525 |
|
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
|
|
G |
Ftl1 |
ferritin light chain 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [arsenite results in increased expression of FTL1 protein] |
CTD |
PMID:15175009 |
|
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
|
|
G |
Fyn |
FYN proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein] |
CTD |
PMID:14572611 |
|
NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
|
|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
ISO EXP |
Glutathione inhibits the reaction [Quartz results in decreased activity of G6PDX protein] Glutathione inhibits the reaction [Asbestos, Amosite results in decreased activity of G6PD protein] Glutathione inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA] |
CTD |
PMID:14613721 PMID:15225644 PMID:18370412 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
ISO EXP |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone binds to GAPDH protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone results in decreased activity of GAPDH protein]; [GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog; Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; Glutathione results in increased metabolism of and results in increased activity of GAPDH protein modified form; NAD analog inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; NADP inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog] Glutathione inhibits the reaction [arsenite results in decreased expression of GAPDH protein] |
CTD |
PMID:15175009 PMID:15788719 PMID:21827172 |
|
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
|
|
G |
Gch1 |
GTP cyclohydrolase 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of GCH1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases abundance increases expression affects chemical synthesis |
ISO EXP |
[[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [Chenodeoxycholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [GCLC results in increased abundance of Glutathione] which results in decreased susceptibility to Cadmium Chloride; [Ginkgo biloba extract results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; [KLF4 results in increased expression of GCLC mRNA] which results in increased abundance of Glutathione; [Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]; GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]] GCLC mRNA results in increased abundance of Glutathione; GCLC protein results in increased abundance of Glutathione [2-tert-butylhydroquinone results in increased activity of GCLC protein] which results in increased abundance of Glutathione; [Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione]; [Buthionine Sulfoximine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [FAS protein results in increased expression of GCLC mRNA] which results in increased chemical synthesis of Glutathione; [FAS protein results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; [GCLC mRNA results in increased abundance of Glutathione] which results in decreased expression of CD36 protein; [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA; GCLC protein affects the reaction [RXRA protein affects the abundance of Glutathione]; GCLC protein inhibits the reaction [Hydrogen Peroxide results in decreased abundance of Glutathione]; GCLC protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione] Glutathione deficiency results in increased expression of GCLC mRNA GCLC polymorphism affects the chemical synthesis of Glutathione [HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione |
CTD |
PMID:7955076 PMID:10544272 PMID:11673643 PMID:12504668 PMID:14978233 PMID:15282320 PMID:15345336 PMID:15707499 PMID:16599007 PMID:17724089 PMID:18556457 PMID:19914271 PMID:20159942 PMID:20621112 PMID:21728338 PMID:21833590 PMID:22762311 PMID:23628456 PMID:26187465 More...
|
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions increases abundance increases chemical synthesis affects response to substance affects metabolic processing decreases abundance increases expression |
ISO EXP |
[Chenodeoxycholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione; [Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione]; GCLM gene SNP results in decreased chemical synthesis of and results in decreased abundance of Glutathione GCLM gene SNP results in increased abundance of Glutathione GCLM protein results in increased chemical synthesis of Glutathione GCLM protein affects the susceptibility to Glutathione GCLM protein affects the metabolism of Glutathione GCLM gene mutant form results in decreased abundance of Glutathione; GCLM protein mutant form results in decreased abundance of Glutathione Glutathione deficiency results in increased expression of GCLM mRNA [GCLM gene mutant form results in decreased abundance of Glutathione] which results in decreased susceptibility to Benzo(a)pyrene; [GCLM gene mutant form results in decreased abundance of Glutathione] which results in increased expression of CBR3 protein; GCLM protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione] |
CTD |
PMID:12975258 PMID:15345336 PMID:17584759 PMID:17724089 PMID:20159942 PMID:20417186 PMID:20621112 PMID:22253057 PMID:23135907 PMID:23704229 PMID:24107266 PMID:25446851 PMID:32715377 More...
|
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Ggt1 |
gamma-glutamyltransferase 1 |
multiple interactions |
ISO |
[acivicin results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione; [hexylglutathione results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione; GGT1 protein affects the reaction [acetaminophen cysteine results in decreased abundance of Glutathione] |
CTD |
PMID:15629191 PMID:19419996 |
|
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
|
|
G |
Glrx |
glutaredoxin |
multiple interactions |
ISO EXP |
[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; [CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]] [GLRX protein co-treated with Glutathione] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein] |
CTD |
PMID:12680778 PMID:20025242 PMID:24451382 |
|
NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680
|
|
G |
Glrx3 |
glutaredoxin 3 |
multiple interactions |
ISO |
[frenolicin B results in decreased activity of GLRX3 protein] which results in decreased abundance of Glutathione |
CTD |
PMID:30661989 |
|
NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
|
|
G |
Gne |
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of GNE mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 5:58,267,189...58,307,396
Ensembl chr 5:58,267,210...58,307,499
|
|
G |
Gnl3 |
G protein nucleolar 3 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of GNL3 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr16:6,207,402...6,213,491
Ensembl chr16:6,207,402...6,213,392
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP ISO |
Glutathione inhibits the reaction [Methyl Parathion results in increased activity of GPT protein] Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of GPT protein] |
CTD |
PMID:20100039 PMID:36689145 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO |
[GPX1 protein co-treated with SOD1 protein] affects the reaction [Acetaminophen results in decreased abundance of Glutathione]; GPX1 protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione] |
CTD |
PMID:16636302 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
|
|
G |
Gsdme |
gasdermin E |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Diquat results in increased cleavage of GSDME protein] |
CTD |
PMID:38128689 |
|
NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806
|
|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases abundance |
ISO |
GSK3B protein mutant form results in increased abundance of Glutathione |
CTD |
PMID:25246272 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions decreases activity affects activity increases expression |
ISO EXP |
[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; [CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate Glutathione results in decreased activity of GSR protein Glutathione inhibits the reaction [Chlorpyrifos results in decreased activity of GSR protein] Glutathione deficiency affects the activity of GSR protein Glutathione deficiency results in increased expression of GSR mRNA 1'-acetoxychavicol acetate analog inhibits the reaction [GSR protein results in increased reduction of Glutathione]; AGT protein promotes the reaction [GSR protein affects the chemical synthesis of Glutathione]; Glutathione inhibits the reaction [Alcohols results in decreased expression of GSR protein] |
CTD |
PMID:15345336 PMID:15707499 PMID:17272743 PMID:20025242 PMID:20230805 PMID:23172834 PMID:24038001 PMID:28803762 More...
|
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Gss |
glutathione synthetase |
multiple interactions |
ISO |
[Arsenic results in increased expression of GSS protein] which results in increased chemical synthesis of Glutathione |
CTD |
PMID:18487201 |
|
NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
|
|
G |
Gsta1 |
glutathione S-transferase alpha 1 |
multiple interactions affects binding affects metabolic processing |
ISO EXP |
GSTA1 protein affects the metabolism of [Busulfan co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Chlorambucil co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Cyclophosphamide metabolite co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]; GSTA1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]; GSTA1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTA1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]; GSTA1 protein binds to and affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]; GSTA1 protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione] Glutathione binds to GSTA1 protein [GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Glutathione; Glutathione inhibits the reaction [Cholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]]; GSTA1 protein affects the metabolism of [2-hydroxymenthofuran co-treated with Glutathione] GSTA1 protein affects the metabolism of Glutathione |
CTD |
PMID:3783048 PMID:7712478 PMID:8886613 PMID:9084911 PMID:9877184 PMID:10437668 PMID:10496977 PMID:10751412 PMID:11115505 PMID:11368548 PMID:11849043 PMID:12147362 PMID:12516103 PMID:14690442 PMID:16890185 More...
|
|
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
|
|
G |
Gsta2 |
glutathione S-transferase alpha 2 |
multiple interactions affects metabolic processing |
ISO EXP |
[GSTA2 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTA2 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine GSTA2 protein affects the metabolism of Glutathione [GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Glutathione; GSTA2 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione] |
CTD |
PMID:8973562 PMID:9084911 PMID:9877184 PMID:28478157 |
|
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
|
|
G |
Gsta3 |
glutathione S-transferase alpha 3 |
affects metabolic processing multiple interactions increases expression |
EXP |
GSTA3 protein affects the metabolism of Glutathione Glutathione inhibits the reaction [Cholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]] Glutathione deficiency results in increased expression of GSTA3 mRNA |
CTD |
PMID:3783048 PMID:6095330 PMID:15345336 |
|
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
|
|
G |
Gsta4 |
glutathione S-transferase alpha 4 |
affects metabolic processing multiple interactions |
ISO EXP |
GSTA4 protein affects the metabolism of Glutathione [GSTA4 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTA4 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine |
CTD |
PMID:14727915 PMID:28478157 |
|
NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
|
|
G |
Gsta5 |
glutathione S-transferase alpha 5 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of GSTA5 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
|
|
G |
Gstk1 |
glutathione S-transferase kappa 1 |
multiple interactions |
ISO |
[diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA |
CTD |
PMID:22564015 |
|
NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
|
|
G |
Gstm1 |
glutathione S-transferase mu 1 |
multiple interactions affects metabolic processing decreases abundance increases expression affects binding |
ISO EXP |
4-O-decyl-gabosine D inhibits the reaction [Glutathione binds to GSTM1 protein]; [GSTM1 protein co-treated with 4-hydroxy-2-nonenal] results in decreased abundance of Glutathione; GSTM1 protein affects the metabolism of [1,2,5,6-dibenzanthracene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Glutathione]; GSTM1 protein affects the metabolism of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTM1 protein affects the metabolism of [Benzo(a)pyrene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [chrysene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTM1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTM1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione] GSTM5 protein affects the metabolism of Glutathione GSTM1 gene mutant form results in decreased abundance of Glutathione Glutathione analog binds to and results in decreased activity of GSTM1 protein; GSTM1 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]; GSTM1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione analog]; GSTM1 protein affects the metabolism of [styrene oxide co-treated with Glutathione] GSTM1 protein affects the metabolism of Glutathione Glutathione deficiency results in increased expression of GSTM1 mRNA |
CTD |
PMID:1883342 PMID:2604743 PMID:2904809 PMID:6095330 PMID:7826396 PMID:8886613 PMID:8973562 PMID:9084911 PMID:9403173 PMID:9545290 PMID:11368548 PMID:11849043 PMID:14979731 PMID:15345336 PMID:21925487 PMID:22085405 PMID:25420021 More...
|
|
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
|
|
G |
Gstm2 |
glutathione S-transferase mu 2 |
affects metabolic processing multiple interactions |
ISO EXP |
GSTM2 protein affects the metabolism of Glutathione [GSTM2 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTM2 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine Dinitrochlorobenzene promotes the reaction [GSTM2 protein affects the metabolism of Glutathione]; GSTM2 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]; GSTM2 protein affects the metabolism of [styrene oxide co-treated with Glutathione] |
CTD |
PMID:2604743 PMID:8924604 PMID:8973562 PMID:9794801 PMID:10858281 PMID:28478157 More...
|
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
|
|
G |
Gstm4 |
glutathione S-transferase mu 4 |
multiple interactions |
ISO |
[GSTM4 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTM4 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine; GSTM4 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione] |
CTD |
PMID:8203914 PMID:28478157 |
|
NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
|
|
G |
Gstm5 |
glutathione S-transferase, mu 5 |
affects metabolic processing |
ISO |
GSTM3 protein affects the metabolism of Glutathione |
CTD |
PMID:9545290 |
|
NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
|
|
G |
Gstm5l |
glutathione S-transferase, mu 5-like |
affects metabolic processing |
EXP |
GSTM5 protein affects the metabolism of Glutathione |
CTD |
PMID:9545290 |
|
NCBI chr 2:195,544,424...195,549,895
Ensembl chr 2:195,544,426...195,628,961
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases activity multiple interactions increases expression affects metabolic processing |
ISO EXP |
Glutathione analog results in decreased activity of GSTP1 protein GSTP1 protein affects the metabolism of [Atrazine co-treated with Glutathione] Glutathione deficiency results in increased expression of GSTP1 mRNA GSTP1 protein affects the metabolism of Glutathione Glutathione inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of GSTP1 protein]; GSTP1 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione] [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP1A1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1A2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1B1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2A6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C8 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2E1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2J2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; [GSTP1 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTP1 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine; GSTP1 gene affects the reaction [Glutathione affects the metabolism of Thiotepa]; GSTP1 protein affects the metabolism of [4-oxo-2-nonenal co-treated with Glutathione]; GSTP1 protein affects the metabolism of [6-bromoacetyl-2-dimethylaminonaphthalene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTP1 protein affects the metabolism of [acrylodan co-treated with Glutathione]; GSTP1 protein affects the metabolism of [Atrazine co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(c)chrysene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(c)phenanthrene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(g)chrysene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTP1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]; GSTP1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTP1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]; GSTP1 protein promotes the reaction [Glutathione binds to Atrazine]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac] |
CTD |
PMID:7712478 PMID:7826396 PMID:8886613 PMID:8973562 PMID:9403173 PMID:9877184 PMID:10334868 PMID:11196146 PMID:11368548 PMID:11849043 PMID:12470677 PMID:13679171 PMID:15115887 PMID:15528046 PMID:18607078 PMID:20570720 PMID:20621112 PMID:24246759 PMID:28478157 More...
|
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
|
|
G |
Gstt1 |
glutathione S-transferase theta 1 |
affects metabolic processing multiple interactions |
ISO EXP |
GSTT1 protein affects the metabolism of Glutathione GSTT1 protein affects the metabolism of [bromodichloromethane co-treated with Glutathione] GSTT1 protein polymorphism affects the metabolism of [Benzene co-treated with Glutathione]; GSTT1 protein promotes the reaction [diepoxybutane binds to Glutathione] |
CTD |
PMID:14727918 PMID:14998683 PMID:15533900 PMID:33381973 |
|
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
|
|
G |
Gstz1 |
glutathione S-transferase zeta 1 |
affects metabolic processing affects binding multiple interactions |
ISO |
GSTZ1 protein affects the metabolism of Glutathione Glutathione binds to GSTZ1 protein GSTZ1 protein binds to and affects the metabolism of Glutathione |
CTD |
PMID:1846734 PMID:9396740 PMID:11327815 PMID:12852784 PMID:15173170 |
|
NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
|
|
G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO |
Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of H2AX protein] Glutathione inhibits the reaction [rubimaillin results in increased phosphorylation of H2AX protein] |
CTD |
PMID:21722719 PMID:35007525 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
|
|
G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
increases expression |
EXP |
Glutathione deficiency results in increased expression of HADHA mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
|
|
G |
Has2 |
hyaluronan synthase 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA] |
CTD |
PMID:21220312 |
|
NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
|
|
G |
Hfe |
homeostatic iron regulator |
increases expression |
EXP |
Glutathione deficiency results in increased expression of HFE mRNA |
CTD |
PMID:15345336 |
|
NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
|
|
G |
Hgf |
hepatocyte growth factor |
increases abundance multiple interactions |
EXP |
HGF protein results in increased abundance of Glutathione [HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione |
CTD |
PMID:10544272 |
|
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [Vanadates results in increased expression of HIF1A protein] |
CTD |
PMID:11641398 PMID:16678800 PMID:17658243 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
|
|
G |
Hk2 |
hexokinase 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Ivermectin results in decreased expression of HK2 protein] |
CTD |
PMID:34904774 |
|
NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
|
|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases expression |
EXP |
Glutathione deficiency results in increased expression of HMGCR mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression affects expression |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; [Acetylcysteine results in increased abundance of Glutathione] inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]; [Dimethyl Fumarate results in decreased abundance of Glutathione] which results in increased expression of HMOX1 protein; Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Air Pollutants results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]] [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [resveratrol results in increased abundance of Glutathione]; Glutathione inhibits the reaction [arsenite results in increased expression of HMOX1 protein] Glutathione deficiency results in increased expression of HMOX1 mRNA; Glutathione results in increased expression of HMOX1 mRNA Glutathione affects the expression of HMOX1 mRNA |
CTD |
PMID:8743975 PMID:12420312 PMID:15175009 PMID:15602829 PMID:16631525 PMID:18078826 PMID:18332044 PMID:20020861 PMID:20621112 PMID:20888885 PMID:20934533 PMID:20961405 PMID:21971136 PMID:23649983 PMID:23691207 PMID:26945724 More...
|
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hnf4a |
hepatocyte nuclear factor 4, alpha |
increases expression |
EXP |
Glutathione deficiency results in increased expression of HNF4A mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
|
|
G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene; Dactinomycin promotes the reaction [[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene] |
CTD |
PMID:9345283 |
|
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
|
|
G |
Hsd17b1 |
hydroxysteroid (17-beta) dehydrogenase 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [sodium arsenite results in decreased activity of HSD17B1 protein] |
CTD |
PMID:20580664 |
|
NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
|
|
G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [sodium arsenite results in decreased activity of HSD3B1 protein] |
CTD |
PMID:20580664 |
|
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
|
|
G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
multiple interactions |
EXP |
Glutathione inhibits the reaction [arsenite results in increased expression of HSPA1B protein] |
CTD |
PMID:15175009 |
|
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
|
|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Glutathione inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein] |
CTD |
PMID:20493918 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
|
|
G |
Hspb1 |
heat shock protein family B (small) member 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [arsenite results in increased expression of HSPB1 protein] |
CTD |
PMID:15175009 |
|
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
|
|
G |
Iapp |
islet amyloid polypeptide |
multiple interactions |
ISO |
IAPP protein inhibits the reaction [[Copper co-treated with Glutathione] results in increased abundance of Hydrogen Peroxide] |
CTD |
PMID:23793354 |
|
NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
[Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:20351055 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
increases abundance multiple interactions |
ISO |
IDH2 protein mutant form results in increased abundance of Glutathione Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Glutathione] |
CTD |
PMID:27469509 |
|
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein] [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IFNG protein; Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]] |
CTD |
PMID:12847270 PMID:16896058 PMID:17079650 PMID:18214930 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions increases expression |
ISO |
deoxynivalenol promotes the reaction [Glutathione results in increased expression of IGF1 mRNA] |
CTD |
PMID:19805407 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
|
|
G |
Igfals |
insulin-like growth factor binding protein, acid labile subunit |
multiple interactions increases expression |
ISO |
deoxynivalenol inhibits the reaction [Glutathione results in increased expression of IGFALS mRNA] |
CTD |
PMID:19805407 |
|
NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677
|
|
G |
Igfbp3 |
insulin-like growth factor binding protein 3 |
multiple interactions increases expression |
ISO |
deoxynivalenol promotes the reaction [Glutathione results in increased expression of IGFBP3 mRNA] |
CTD |
PMID:19805407 |
|
NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
|
|
G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions affects abundance |
ISO |
GCLC protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]; GCLM protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]; Glutathione inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]] IKBKB protein affects the abundance of Glutathione |
CTD |
PMID:17067557 PMID:20159942 |
|
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
|
|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL10 protein |
CTD |
PMID:18214930 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
|
|
G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL13 protein; Glutathione inhibits the reaction [[Thimerosal co-treated with Lipopolysaccharides] results in increased secretion of IL13 protein] |
CTD |
PMID:17079650 PMID:18214930 |
|
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
|
|
G |
Il1b |
interleukin 1 beta |
increases abundance decreases expression multiple interactions |
ISO |
IL1B protein results in increased abundance of Glutathione Glutathione results in decreased expression of IL1B mRNA Glutathione deficiency promotes the reaction [Phenol results in increased secretion of IL1B protein]; Glutathione deficiency promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of IL1B protein] |
CTD |
PMID:10802230 PMID:17922553 PMID:22385246 PMID:26149495 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il33 |
interleukin 33 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of IL33 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
|
|
G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
[IL4 gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased abundance of Glutathione [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL4 protein; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein] |
CTD |
PMID:18214930 PMID:22107450 PMID:27634759 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Glutathione analog promotes the reaction [Ozone results in increased expression of IL6 protein]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]] |
CTD |
PMID:15379216 PMID:17079650 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Ins1 |
insulin 1 |
multiple interactions |
ISO |
[INS1 protein co-treated with Glutathione] affects the activity of CAT protein; [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of CAT mRNA; [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of SOD2 mRNA |
CTD |
PMID:25362599 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
|
|
G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
INS protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione] |
CTD |
PMID:26739624 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
|
|
G |
Isg20 |
interferon stimulated exonuclease gene 20 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ISG20 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
|
|
G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA] |
CTD |
PMID:16357311 |
|
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
|
|
G |
Jak2 |
Janus kinase 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein] |
CTD |
PMID:12847270 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases phosphorylation |
ISO |
Glutathione affects the reaction [Sodium Selenite results in increased expression of JUN mRNA]; Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Glutathione inhibits the reaction [tert-Butylhydroperoxide results in increased expression of JUN mRNA] Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of JUN protein] Glutathione deficiency results in increased phosphorylation of JUN protein |
CTD |
PMID:12774022 PMID:15105052 PMID:15520183 PMID:18449455 PMID:30266318 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUNB mRNA] |
CTD |
PMID:15520183 |
|
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
|
|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions increases abundance |
ISO EXP |
[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione; [Plant Extracts results in decreased expression of KEAP1 protein] which results in increased chemical synthesis of Glutathione; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione] KEAP1 gene mutant form results in increased abundance of Glutathione Glutathione inhibits the reaction [falcarindiol binds to and results in increased alkylation of KEAP1 protein] [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA; Glutathione inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein]; Glutathione inhibits the reaction [2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased glutathionylation of KEAP1 protein]; KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione] |
CTD |
PMID:19608619 PMID:20026152 PMID:20800667 PMID:21972102 PMID:22762311 PMID:25807370 PMID:26827822 More...
|
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
|
|
G |
Klf4 |
KLF transcription factor 4 |
increases abundance multiple interactions |
ISO |
KLF4 results in increased abundance of Glutathione [KLF4 results in increased expression of GCLC mRNA] which results in increased abundance of Glutathione |
CTD |
PMID:21833590 |
|
NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
|
|
G |
Klkb1 |
kallikrein B1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of KLKB1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
|
|
G |
Krt18 |
keratin 18 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of KRT18 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 Ensembl chr10:133,157,475...133,161,166
|
|
G |
Lck |
LCK proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LCK protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LCK protein] |
CTD |
PMID:14572611 |
|
NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
|
|
G |
Lepr |
leptin receptor |
multiple interactions |
EXP |
LEPR gene mutant form results in increased oxidation of and results in decreased abundance of Glutathione |
CTD |
PMID:29743445 |
|
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
|
|
G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP ISO |
Glutathione inhibits the reaction [sodium arsenite results in decreased expression of LHB protein] Glutathione inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of PGR mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA] |
CTD |
PMID:20580664 PMID:21220312 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
|
|
G |
Lrp1 |
LDL receptor related protein 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of LRP1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
|
|
G |
Lyn |
LYN proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein] |
CTD |
PMID:14572611 |
|
NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
|
|
G |
Maob |
monoamine oxidase B |
multiple interactions |
ISO |
Glutathione inhibits the reaction [MAOB protein results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole] |
CTD |
PMID:26686552 |
|
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
|
|
G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases expression multiple interactions |
EXP ISO |
Glutathione deficiency results in increased expression of MAP1LC3B mRNA Glutathione inhibits the reaction [Apigenin results in increased expression of MAP1LC3B protein modified form]; Glutathione inhibits the reaction [Ivermectin results in increased expression of and results in increased lipidation of MAP1LC3B protein] |
CTD |
PMID:15345336 PMID:29247770 PMID:34904774 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
|
|
G |
Map2 |
microtubule-associated protein 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Particulate Matter results in decreased expression of MAP2 mRNA] |
CTD |
PMID:28153600 |
|
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP ISO |
Glutathione inhibits the reaction [Cadmium Chloride results in increased activity of MAPK1 protein]; Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased activity of MAPK1 protein] Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [ciglitazone results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK1 protein; Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Glutathione inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:10658192 PMID:12083801 PMID:14566972 PMID:15252869 PMID:21971136 PMID:22767315 PMID:23370007 PMID:24015256 More...
|
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP ISO |
Glutathione inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK3 protein] Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [ciglitazone results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK3 protein; Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:12083801 PMID:15252869 PMID:21971136 PMID:22767315 PMID:24015256 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO EXP |
Glutathione deficiency promotes the reaction [antimony trioxide results in increased activity of MAPK8 protein] Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK8 protein] Glutathione inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Dopamine results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:16112521 PMID:17481858 PMID:20423716 PMID:22767315 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO EXP |
Glutathione inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK9 protein] Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:20423716 PMID:22767315 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
|
|
G |
Me1 |
malic enzyme 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ME1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
|
|
G |
Met |
MET proto-oncogene, receptor tyrosine kinase |
multiple interactions |
ISO |
MET gene mutant form promotes the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased oxidation of Glutathione] |
CTD |
PMID:27394961 |
|
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
|
|
G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
multiple interactions |
ISO |
Glutathione affects the reaction [MGMT protein results in increased susceptibility to Mitomycin] |
CTD |
PMID:16039682 |
|
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
|
|
G |
Mgst1 |
microsomal glutathione S-transferase 1 |
multiple interactions |
EXP |
[Diamide co-treated with Glutathione] results in increased activity of MGST1 protein; [Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein; Bongkrekic Acid inhibits the reaction [[Diamide co-treated with Glutathione] results in increased activity of MGST1 protein]; Cyclosporine inhibits the reaction [[Diamide co-treated with Glutathione] results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Glutathione binds to and results in increased activity of MGST1 protein; Leukotriene C4 inhibits the reaction [Glutathione binds to and results in increased activity of MGST1 protein]; MGST1 protein affects the metabolism of [6-bromoacetyl-2-dimethylaminonaphthalene co-treated with Glutathione]; MGST1 protein affects the metabolism of [acrylodan co-treated with Glutathione]; sodium arsenite inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein] |
CTD |
PMID:9890956 PMID:12470677 PMID:16386761 PMID:18634816 |
|
NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
decreases secretion |
ISO |
Glutathione results in decreased secretion of MMP2 protein |
CTD |
PMID:15147517 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
affects binding multiple interactions decreases secretion |
ISO |
Glutathione binds to MMP9 protein Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of MMP9 protein] Glutathione results in decreased secretion of MMP9 protein Glutathione inhibits the reaction [4-aminophenylmercuriacetate results in increased activity of MMP9 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glutathione binds to MMP9 protein] |
CTD |
PMID:15147517 PMID:17015178 PMID:17640567 PMID:21722719 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; [[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione] which results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione; [MPO protein results in increased oxidation of Phenolsulfonphthalein] which results in decreased abundance of Glutathione; desmethylnaproxen promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]; Glutathione promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Glutathione promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile] |
CTD |
PMID:19462961 PMID:25614581 PMID:28754375 PMID:31288001 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Mst1r |
macrophage stimulating 1 receptor |
multiple interactions |
ISO |
MST1R protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione] |
CTD |
PMID:22575169 |
|
NCBI chr 8:108,596,100...108,611,441
Ensembl chr 8:108,597,299...108,612,455
|
|
G |
Mt1 |
metallothionein 1 |
increases expression multiple interactions |
EXP ISO |
Glutathione deficiency results in increased expression of MT1A mRNA [MT1 protein co-treated with MT2 protein] affects the reaction [Glutathione affects the susceptibility to Doxorubicin] |
CTD |
PMID:15345336 PMID:20600803 |
|
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
|
|
G |
Mt2A |
metallothionein 2A |
multiple interactions |
ISO |
[MT1 protein co-treated with MT2 protein] affects the reaction [Glutathione affects the susceptibility to Doxorubicin] |
CTD |
PMID:20600803 |
|
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
|
|
G |
Mtf1 |
metal-regulatory transcription factor 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Cadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]] |
CTD |
PMID:9507026 |
|
NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
|
|
G |
Mtr |
5-methyltetrahydrofolate-homocysteine methyltransferase |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] |
CTD |
PMID:26989453 |
|
NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
affects abundance multiple interactions |
ISO EXP |
MYC protein affects the abundance of Glutathione Glutathione inhibits the reaction [arsenite results in increased expression of MYC mRNA] |
CTD |
PMID:9848127 PMID:12226097 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases abundance decreases abundance affects abundance |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased abundance of Glutathione; [[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein; [Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein; [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione]; Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid affects the localization of NFE2L2 protein]; Glutathione inhibits the reaction [Air Pollutants results in increased expression of NFE2L2 protein]; NFE2L2 promotes the reaction [Chalcone analog results in increased abundance of Glutathione]; NFE2L2 protein affects the reaction [Silver results in increased abundance of Glutathione] NFE2L2 protein results in increased abundance of Glutathione NFE2L2 gene mutant form results in decreased abundance of Glutathione NFE2L2 protein affects the abundance of Glutathione NFE2L2 protein inhibits the reaction [triptolide results in decreased abundance of Glutathione] [ATG5 gene mutant form results in increased activity of NFE2L2 protein] affects the reaction [Acetaminophen affects the abundance of Glutathione]; [ATG5 gene mutant form results in increased activity of NFE2L2 protein] which affects the abundance of Glutathione; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased abundance of Glutathione; Glutathione inhibits the reaction [2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form promotes the reaction [Diquat results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [Dinitrochlorobenzene results in decreased abundance of Glutathione]; sulforaphane affects the reaction [NFE2L2 affects the abundance of Glutathione] NFE2L2 affects the abundance of Glutathione; NFE2L2 protein affects the abundance of Glutathione |
CTD |
PMID:11287661 PMID:16524372 PMID:16631525 PMID:19303893 PMID:19608619 PMID:20124447 PMID:20800667 PMID:21728338 PMID:21971136 PMID:22491424 PMID:22546375 PMID:22762311 PMID:22820427 PMID:23649983 PMID:23764462 PMID:24211276 PMID:27633142 PMID:28219650 PMID:29618784 PMID:31299238 More...
|
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]] |
CTD |
PMID:16219905 PMID:17640567 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]] |
CTD |
PMID:17067557 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Ngf |
nerve growth factor |
multiple interactions affects reduction affects oxidation affects activity |
EXP ISO |
N-acetylsphingosine affects the reaction [Glutathione affects the activity of NGF protein] NGF protein affects the reduction of Glutathione NGF protein affects the oxidation of Glutathione |
CTD |
PMID:12381813 PMID:23472850 |
|
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
|
|
G |
Nlgn3 |
neuroligin 3 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of NLGN3 mRNA]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased methylation of NLGN3 promoter]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 protein]; Glutathione inhibits the reaction [Particulate Matter results in increased methylation of NLGN3 promoter] |
CTD |
PMID:27624276 |
|
NCBI chr X:66,427,926...66,457,378
Ensembl chr X:66,429,458...66,451,876
|
|
G |
Nnmt |
nicotinamide N-methyltransferase |
increases abundance |
ISO |
NNMT protein results in increased abundance of Glutathione |
CTD |
PMID:31909875 |
|
NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]] Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of NOS2 protein]; Glutathione inhibits the reaction [orazipone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] |
CTD |
PMID:17640567 PMID:18039960 PMID:21722719 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nox4 |
NADPH oxidase 4 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NOX4 protein] |
CTD |
PMID:36689145 |
|
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions decreases expression |
EXP ISO |
Glutathione deficiency results in increased expression of NQO1 mRNA Glutathione inhibits the reaction [2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased expression of NQO1 protein] Glutathione results in decreased expression of NQO1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA; NQO1 protein inhibits the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; NQO1 protein polymorphism promotes the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA] |
CTD |
PMID:15345336 PMID:20800667 PMID:21034357 PMID:21971136 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of NR0B2 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
|
|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions |
ISO |
NR1I3 gene mutant form inhibits the reaction [pyrene results in decreased abundance of Glutathione] |
CTD |
PMID:26160115 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
|
|
G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of ATF4 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP7 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP8 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of PARP1 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of DDIT3 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of SESN2 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of XBP1 protein alternative form]; Glutathione inhibits the reaction [NR4A1 protein affects the phosphorylation of EIF2AK3 protein] |
CTD |
PMID:24515801 PMID:26035713 |
|
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
|
|
G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [Permethrin results in increased expression of NR4A2 mRNA] |
CTD |
PMID:28943456 |
|
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
|
|
G |
Nrxn1 |
neurexin 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 protein]; Glutathione inhibits the reaction [Particulate Matter results in increased methylation of NRXN1 promoter] |
CTD |
PMID:27624276 |
|
NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710
|
|
G |
Oaf |
out at first homolog |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of OAF mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
|
|
G |
Odc1 |
ornithine decarboxylase 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [mezerein results in increased activity of ODC1 protein]; Glutathione inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] |
CTD |
PMID:3098411 |
|
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
|
|
G |
Ogdh |
oxoglutarate dehydrogenase |
multiple interactions |
EXP |
[GLRX protein co-treated with Glutathione] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein]; Glutathione promotes the reaction [Diamide results in decreased activity of OGDH protein] |
CTD |
PMID:12680778 |
|
NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
|
|
G |
Ogg1 |
8-oxoguanine DNA glycosylase |
multiple interactions |
ISO |
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA |
CTD |
PMID:22564015 |
|
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
|
|
G |
Otub1 |
OTU deubiquitinase, ubiquitin aldehyde binding 1 |
multiple interactions |
ISO |
[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in increased chemical synthesis of Glutathione |
CTD |
PMID:35234341 |
|
NCBI chr 1:204,387,215...204,395,495
Ensembl chr 1:204,387,215...204,395,483
|
|
G |
Panx1 |
Pannexin 1 |
decreases oxidation |
ISO |
PANX1 gene mutant form results in decreased oxidation of Glutathione |
CTD |
PMID:29246445 |
|
NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774
|
|
G |
Park7 |
Parkinsonism associated deglycase |
increases abundance |
ISO |
PARK7 protein results in increased abundance of Glutathione |
CTD |
PMID:18331584 |
|
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
Glutathione deficiency promotes the reaction [antimony trioxide results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [N-methylisoindigotin results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of PARP1 protein] |
CTD |
PMID:14660655 PMID:16112521 PMID:24036456 PMID:24515801 PMID:26887594 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Pcsk9 |
proprotein convertase subtilisin/kexin type 9 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of PCSK9 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
|
|
G |
Pdgfrb |
platelet derived growth factor receptor beta |
increases abundance |
ISO |
PDGFRB protein results in increased abundance of Glutathione |
CTD |
PMID:29857117 |
|
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
|
|
G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein] |
CTD |
PMID:17171638 |
|
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
|
|
G |
Pfkm |
phosphofructokinase, muscle |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Ivermectin results in decreased expression of PFKM protein] |
CTD |
PMID:34904774 |
|
NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
|
|
G |
Pgr |
progesterone receptor |
multiple interactions |
ISO |
Glutathione inhibits the reaction [LHB protein results in increased abundance of PGR mRNA] |
CTD |
PMID:21220312 |
|
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
|
|
G |
Plin2 |
perilipin 2 |
multiple interactions |
ISO |
SOD1 gene mutant form promotes the reaction [Glutathione results in increased expression of PLIN2 protein modified form] |
CTD |
PMID:27349771 |
|
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
|
|
G |
Pon1 |
paraoxonase 1 |
multiple interactions |
ISO |
PON1 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione] |
CTD |
PMID:20079818 |
|
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
|
|
G |
Pon3 |
paraoxonase 3 |
multiple interactions |
ISO |
PON3 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione] |
CTD |
PMID:20079818 |
|
NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
|
|
G |
Ppan |
peter pan homolog |
increases expression |
EXP |
Glutathione deficiency results in increased expression of PPAN mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 8:19,423,908...19,427,941
Ensembl chr 8:19,423,961...19,427,938
|
|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases expression multiple interactions |
ISO |
Glutathione results in increased expression of PPARA mRNA Glutathione inhibits the reaction [Alcohols results in decreased expression of PPARA protein]; Quercetin promotes the reaction [Glutathione results in increased expression of PPARA mRNA] |
CTD |
PMID:25204422 PMID:28803762 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
|
|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
ISO |
Glutathione analog results in increased expression of PPARGC1A mRNA |
CTD |
PMID:23056435 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
|
|
G |
Ppat |
phosphoribosyl pyrophosphate amidotransferase |
increases expression |
EXP |
Glutathione deficiency results in increased expression of PPAT mRNA |
CTD |
PMID:20621112 |
|
NCBI chr14:31,215,741...31,250,144
Ensembl chr14:31,216,165...31,250,144
|
|
G |
Ppp1r3c |
protein phosphatase 1, regulatory subunit 3C |
increases expression |
EXP |
Glutathione deficiency results in increased expression of PPP1R3C mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961
|
|
G |
Prdx1 |
peroxiredoxin 1 |
multiple interactions |
ISO |
[frenolicin B results in decreased activity of PRDX1 protein] which results in decreased abundance of Glutathione |
CTD |
PMID:30661989 |
|
NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
|
|
G |
Prdx2 |
peroxiredoxin 2 |
multiple interactions |
ISO |
SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of PRDX2 protein] |
CTD |
PMID:27349771 |
|
NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
|
|
G |
Prdx6 |
peroxiredoxin 6 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of PRDX6 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
|
|
G |
Prim2 |
DNA primase subunit 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of PRIM2 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 9:35,692,376...35,904,521
Ensembl chr 9:35,692,376...35,903,030
|
|
G |
Prkcd |
protein kinase C, delta |
multiple interactions affects abundance |
ISO |
Glutathione inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of PRKCD protein]; Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein] PRKCD protein affects the abundance of Glutathione |
CTD |
PMID:15131007 PMID:15707588 PMID:17171638 |
|
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
|
|
G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
affects abundance |
ISO |
PRKN protein affects the abundance of Glutathione |
CTD |
PMID:12915482 |
|
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
|
|
G |
Prnp |
prion protein |
multiple interactions |
ISO |
PRNP protein inhibits the reaction [manganese chloride results in decreased abundance of Glutathione] |
CTD |
PMID:17483122 |
|
NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
|
|
G |
Procr |
protein C receptor |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Doxorubicin results in decreased expression of PROCR protein] |
CTD |
PMID:17172434 |
|
NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903
|
|
G |
Ptbp1 |
polypyrimidine tract binding protein 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of PTBP1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 7:9,842,574...9,852,332
Ensembl chr 7:9,842,574...9,852,397
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO EXP |
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]] Glutathione inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 mRNA]; Glutathione inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 protein] Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of PTGS2 protein]; Glutathione inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA] |
CTD |
PMID:17640567 PMID:21220312 PMID:21722719 PMID:22767315 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Ptma |
prothymosin alpha |
increases abundance multiple interactions decreases abundance |
ISO |
PTMA protein alternative form results in increased abundance of Glutathione PTMA protein inhibits the reaction [Dexamethasone results in decreased abundance of Glutathione] PTMA protein alternative form results in decreased abundance of Glutathione |
CTD |
PMID:9147362 PMID:19442654 |
|
NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
|
|
G |
Ptpn2 |
protein tyrosine phosphatase, non-receptor type 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [quinone results in decreased activity of PTPN2 protein] |
CTD |
PMID:31248982 |
|
NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
|
|
G |
Ptprf |
protein tyrosine phosphatase, receptor type, F |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of PTPRF mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023
|
|
G |
Ptprs |
protein tyrosine phosphatase, receptor type, S |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of PTPRS mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 9:1,245,408...1,307,015
Ensembl chr 9:1,245,410...1,306,947
|
|
G |
Rb1 |
RB transcriptional corepressor 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Doxorubicin results in decreased phosphorylation of RB1 protein]; Glutathione inhibits the reaction [Levamisole results in decreased expression of RB1 protein] |
CTD |
PMID:11139434 PMID:22927544 |
|
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
|
|
G |
Rbm27 |
RNA binding motif protein 27 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of RBM27 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr18:34,273,527...34,336,124
Ensembl chr18:34,273,527...34,334,126
|
|
G |
Rdh16 |
retinol dehydrogenase 16 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of RDH2 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 7:63,616,711...63,625,053
Ensembl chr 7:63,597,536...63,624,124
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases glutathionylation affects abundance |
ISO |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]; [cinnamaldehyde results in increased abundance of Glutathione] which results in increased glutathionylation of RELA protein; [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein affects the localization of RELA protein]; [Glutathione co-treated with Hydrogen Peroxide] results in increased glutathionylation of RELA protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]] Glutathione results in increased glutathionylation of RELA protein RELA protein affects the abundance of Glutathione Glutathione affects the reaction [Sodium Selenite results in increased expression of RELA mRNA]; Glutathione inhibits the reaction [Alcohols results in increased expression of RELA protein] |
CTD |
PMID:16219905 PMID:17640567 PMID:18449455 PMID:20116392 PMID:20159942 PMID:20351055 PMID:28803762 More...
|
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Reln |
reelin |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of RELN mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
|
|
G |
Retreg1 |
reticulophagy regulator 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of RETREG1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 2:76,335,609...76,474,817
Ensembl chr 2:76,335,609...76,493,898
|
|
G |
Rfk |
riboflavin kinase |
increases abundance |
ISO |
RFK protein results in increased abundance of Glutathione |
CTD |
PMID:21308351 |
|
NCBI chr 1:214,799,880...214,807,440
Ensembl chr 1:214,799,825...214,807,438 Ensembl chr X:214,799,825...214,807,438
|
|
G |
Rps6 |
ribosomal protein S6 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of RPS6 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
|
|
G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of RPS6KB1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
|
|
G |
Rreb1 |
ras responsive element binding protein 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of RREB1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr17:26,876,687...27,002,554
Ensembl chr17:26,876,697...27,002,615
|
|
G |
Rup2 |
urinary protein 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of RUP2 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 8:35,336,764...35,340,345
Ensembl chr 8:35,336,764...35,489,103
|
|
G |
Rxra |
retinoid X receptor alpha |
multiple interactions affects abundance |
ISO |
GCLC protein affects the reaction [RXRA protein affects the abundance of Glutathione] |
CTD |
PMID:14978233 |
|
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
|
|
G |
Samd4a |
sterile alpha motif domain containing 4A |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SAMD4A mRNA |
CTD |
PMID:20621112 |
|
NCBI chr15:20,135,994...20,352,131
Ensembl chr15:20,134,377...20,348,380
|
|
G |
Scd |
stearoyl-CoA desaturase |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of SCD1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
|
|
G |
Sdf2l1 |
stromal cell-derived factor 2-like 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SDF2L1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902
|
|
G |
Sele |
selectin E |
multiple interactions |
ISO |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA] |
CTD |
PMID:21971136 |
|
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
|
|
G |
Selenow |
selenoprotein W |
multiple interactions |
ISO |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased expression of SELENOW mRNA; Glutathione deficiency promotes the reaction [Methylmercury Compounds results in decreased expression of SELENOW mRNA] |
CTD |
PMID:15823556 |
|
NCBI chr 1:76,599,441...76,604,514
Ensembl chr 1:76,598,779...76,604,724 Ensembl chr 1:76,598,779...76,604,724
|
|
G |
Sesn2 |
sestrin 2 |
increases expression multiple interactions |
EXP ISO |
Glutathione deficiency results in increased expression of SESN2 mRNA Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of SESN2 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of SESN2 protein]; Glutathione inhibits the reaction [p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in increased expression of SESN2 protein] |
CTD |
PMID:20621112 PMID:26035713 |
|
NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
|
|
G |
Sfxn1 |
sideroflexin 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SFXN1 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529
|
|
G |
Sgk2 |
serum/glucocorticoid regulated kinase 2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SGK2 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480
|
|
G |
Sirt1 |
sirtuin 1 |
multiple interactions decreases abundance |
ISO |
[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]; GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]] SIRT1 protein results in decreased abundance of Glutathione |
CTD |
PMID:24451382 PMID:29134718 |
|
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
|
|
G |
Slc22a6 |
solute carrier family 22 member 6 |
multiple interactions |
ISO |
SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Glutathione] |
CTD |
PMID:12606766 |
|
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
|
|
G |
Slc25a10 |
solute carrier family 25 member 10 |
multiple interactions increases uptake |
EXP |
[SLC25A10 protein co-treated with Glutathione] results in decreased susceptibility to S-(1,2-dichlorovinyl)cysteine; [SLC25A10 protein co-treated with Glutathione] results in decreased susceptibility to tert-Butylhydroperoxide SLC25A10 protein results in increased uptake of Glutathione |
CTD |
PMID:12388626 |
|
NCBI chr10:105,765,598...105,775,159
Ensembl chr10:105,765,372...105,773,556
|
|
G |
Slc25a20 |
solute carrier family 25 member 20 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Mercuric Chloride results in decreased activity of SLC25A20 protein]; Glutathione inhibits the reaction [methylmercuric chloride results in decreased activity of SLC25A20 protein] |
CTD |
PMID:25849418 |
|
NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
|
|
G |
Slc25a33 |
solute carrier family 25 member 33 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SLC25A33 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 5:160,195,040...160,219,961
Ensembl chr 5:160,195,042...160,219,961
|
|
G |
Slc31a1 |
solute carrier family 31 member 1 |
multiple interactions |
ISO |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [SLC31A1 protein results in increased import of Copper] |
CTD |
PMID:23426973 |
|
NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
|
|
G |
Slc39a2 |
solute carrier family 39 member 2 |
multiple interactions |
ISO |
[SLC39A2 protein co-treated with zinc chloride] results in increased abundance of Glutathione |
CTD |
PMID:18385089 |
|
NCBI chr15:24,590,738...24,592,850
Ensembl chr15:24,590,738...24,592,850
|
|
G |
Slc3a2 |
solute carrier family 3 member 2 |
multiple interactions |
ISO |
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione |
CTD |
PMID:22216172 |
|
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
|
|
G |
Slc5a6 |
solute carrier family 5 member 6 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SLC5A6 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712
|
|
G |
Slc7a11 |
solute carrier family 7 member 11 |
increases abundance multiple interactions |
ISO |
SLC7A11 results in increased abundance of Glutathione [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in increased chemical synthesis of Glutathione; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species; [SLC7A11 gene mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Glutathione; [SLC7A11 results in increased abundance of Glutathione] which results in decreased abundance of Reactive Oxygen Species; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione |
CTD |
PMID:19015640 PMID:22216172 PMID:23085521 PMID:35234341 |
|
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
|
|
G |
Slc9a9 |
solute carrier family 9 member A9 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SLC9A9 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 8:95,232,889...95,797,262
Ensembl chr 8:95,232,905...95,796,318
|
|
G |
Snca |
synuclein alpha |
multiple interactions decreases abundance |
EXP ISO |
Glutathione inhibits the reaction [manganese chloride promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]] Dopamine inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]; ferrous sulfate inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]; geraniol inhibits the reaction [SNCA protein results in decreased abundance of Glutathione] |
CTD |
PMID:23353026 PMID:27026137 PMID:27424009 |
|
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions increases abundance affects activity affects abundance |
ISO |
[Glutathione results in increased reduction of SOD1 protein] promotes the reaction [Hydrogen Peroxide results in increased oxidation of SOD1 protein modified form]; [Glutathione results in increased reduction of SOD1 protein] which results in increased susceptibility to Hydrogen Peroxide; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]; Glutathione promotes the reaction [SOD1 protein binds to Oligodeoxyribonucleotides]; Glutathione results in increased reduction of and results in decreased activity of SOD1 protein SOD1 gene mutant form results in increased abundance of Glutathione Glutathione deficiency affects the activity of SOD1 protein [GPX1 protein co-treated with SOD1 protein] affects the reaction [Acetaminophen results in decreased abundance of Glutathione]; SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of ATF6 protein modified form]; SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of PRDX2 protein]; SOD1 gene mutant form promotes the reaction [Glutathione results in increased expression of PLIN2 protein modified form]; Thioacetamide promotes the reaction [SOD1 gene mutant form results in increased abundance of Glutathione] SOD1 protein affects the abundance of Glutathione |
CTD |
PMID:15707499 PMID:16101137 PMID:16377630 PMID:16636302 PMID:22867017 PMID:27349771 PMID:31162603 More...
|
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G |
Sod2 |
superoxide dismutase 2 |
increases abundance multiple interactions |
ISO |
SOD2 protein results in increased abundance of Glutathione [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of SOD2 mRNA Glutathione affects the reaction [SOD2 protein affects the activity of CASP9 protein]; Glutathione affects the reaction [SOD2 protein results in decreased susceptibility to Doxorubicin]; Glutathione affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA] |
CTD |
PMID:15130278 PMID:16101137 PMID:18594523 PMID:25362599 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sp1 |
Sp1 transcription factor |
multiple interactions decreases expression |
ISO |
Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP1 protein] Glutathione results in decreased expression of SP1 |
CTD |
PMID:18556457 PMID:20435036 |
|
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
|
|
G |
Sp3 |
Sp3 transcription factor |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP3 protein] |
CTD |
PMID:20435036 |
|
NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
|
|
G |
Sp4 |
Sp4 transcription factor |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP4 protein] |
CTD |
PMID:20435036 |
|
NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126
|
|
G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein]; Glutathione inhibits the reaction [Ivermectin results in decreased expression of SQSTM1 protein] |
CTD |
PMID:22927544 PMID:34904774 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
|
|
G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Alcohols results in increased expression of SREBF1 protein] |
CTD |
PMID:28803762 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
|
|
G |
Srek1ip1 |
SREK1-interacting protein 1 |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of SREK1IP1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 2:35,975,978...35,999,636
Ensembl chr 2:35,975,989...35,999,636 Ensembl chr 7:35,975,989...35,999,636
|
|
G |
Srxn1 |
sulfiredoxin 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SRXN1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
|
|
G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein] Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]] |
CTD |
PMID:12847270 PMID:16896058 |
|
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions affects abundance |
ISO |
Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]] STAT3 protein affects the abundance of Glutathione |
CTD |
PMID:16896058 PMID:20224768 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
G |
Sult1c2a |
sulfotransferase family 1C member 2A |
increases expression |
EXP |
Glutathione deficiency results in increased expression of SULT1C2 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734
|
|
G |
Syn1 |
synapsin I |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Particulate Matter results in decreased expression of SYN1 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of SYN1 protein] |
CTD |
PMID:27624276 PMID:28153600 |
|
NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396
|
|
G |
Taldo1 |
transaldolase 1 |
multiple interactions decreases abundance |
ISO |
Acetylcysteine inhibits the reaction [TALDO1 gene mutant form results in decreased abundance of Glutathione] |
CTD |
PMID:19436114 |
|
NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
|
|
G |
Tert |
telomerase reverse transcriptase |
increases expression multiple interactions |
ISO |
Glutathione results in increased expression of TERT protein Glutathione inhibits the reaction [Camptothecin results in increased expression of TERT protein] |
CTD |
PMID:30851366 |
|
NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
|
|
G |
Tes |
testin LIM domain protein |
increases expression |
EXP |
Glutathione deficiency results in increased expression of TES mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 4:45,365,304...45,403,829
Ensembl chr 4:45,365,285...45,403,829
|
|
G |
Tet1 |
tet methylcytosine dioxygenase 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Particulate Matter results in increased expression of TET1 mRNA] |
CTD |
PMID:28153600 |
|
NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions decreases abundance |
EXP ISO |
diphenyleneiodonium inhibits the reaction [TGFB1 protein results in decreased abundance of Glutathione]; Rotenone inhibits the reaction [TGFB1 protein results in decreased abundance of Glutathione] |
CTD |
PMID:11260395 PMID:14732287 PMID:34769192 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Thpo |
thrombopoietin |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of THPO mRNA |
CTD |
PMID:20621112 |
|
Ensembl chr11:80,182,820...80,188,167
|
|
G |
Tlr2 |
toll-like receptor 2 |
decreases expression |
ISO |
Glutathione results in decreased expression of TLR2 mRNA |
CTD |
PMID:22385246 |
|
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
|
|
G |
Tlr4 |
toll-like receptor 4 |
decreases expression |
ISO |
Glutathione results in decreased expression of TLR4 mRNA |
CTD |
PMID:22385246 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
|
|
G |
Tmcc1 |
transmembrane and coiled-coil domain family 1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of TMCC1 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 4:149,069,252...149,239,585
Ensembl chr 4:149,069,260...149,239,620
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions decreases abundance decreases expression increases chemical synthesis affects abundance increases abundance |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein]; [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein; [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein affects the localization of RELA protein]; [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in decreased abundance of Glutathione]; cyanidin-3-O-beta-glucopyranoside inhibits the reaction [TNF protein results in decreased abundance of Glutathione]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA] Glutathione affects the reaction [Alcohols results in increased expression of TNF protein] Glutathione results in decreased expression of TNF mRNA TNF protein results in increased chemical synthesis of Glutathione TNF protein affects the abundance of Glutathione TNF protein results in increased abundance of Glutathione |
CTD |
PMID:9374527 PMID:9535218 PMID:10802230 PMID:16219905 PMID:16271621 PMID:17079650 PMID:17640567 PMID:19900513 PMID:20351055 PMID:20626112 PMID:21971136 PMID:22385246 PMID:27793764 PMID:28803762 More...
|
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tnfaip6 |
TNF alpha induced protein 6 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA] |
CTD |
PMID:21220312 |
|
NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
|
|
G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
affects abundance |
ISO |
TNFRSF1A protein affects the abundance of Glutathione |
CTD |
PMID:20159942 |
|
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
|
|
G |
Top2a |
DNA topoisomerase II alpha |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of TOP2A protein] |
CTD |
PMID:21497582 |
|
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions increases glutathionylation decreases abundance increases expression |
ISO |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [Benzo(a)pyrene results in increased activity of TP53 protein]; Dithiothreitol inhibits the reaction [Glutathione results in increased glutathionylation of TP53 protein]; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]; Glutathione inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein]; Glutathione inhibits the reaction [Doxorubicin results in increased expression of TP53 protein] TP53 protein results in decreased abundance of Glutathione Glutathione results in increased expression of TP53 protein |
CTD |
PMID:10897038 PMID:12807757 PMID:12967322 PMID:17555331 PMID:19202565 PMID:22927544 PMID:27634759 More...
|
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Tpo |
thyroid peroxidase |
multiple interactions decreases activity |
ISO |
arsenic trioxide promotes the reaction [Glutathione results in decreased activity of TPO protein]; Glutathione promotes the reaction [arsenic trioxide results in decreased activity of TPO protein] |
CTD |
PMID:25595679 |
|
NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
|
|
G |
Trib3 |
tribbles pseudokinase 3 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of TRIB3 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
|
|
G |
Trpa1 |
transient receptor potential cation channel, subfamily A, member 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [agathic acid results in increased activity of TRPA1 protein]; Glutathione inhibits the reaction [Particulate Matter results in increased activity of TRPA1 protein]; Glutathione inhibits the reaction [phenalen-1-one results in increased activity of TRPA1 protein] |
CTD |
PMID:23541125 PMID:30945539 |
|
NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
|
|
G |
Trpm2 |
transient receptor potential cation channel, subfamily M, member 2 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; Glutathione inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] |
CTD |
PMID:33309544 |
|
NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
|
|
G |
Tsku |
tsukushi, small leucine rich proteoglycan |
increases expression |
EXP |
Glutathione deficiency results in increased expression of TSKU mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588
|
|
G |
Tubb3 |
tubulin, beta 3 class III |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Particulate Matter results in decreased expression of TUBB3 mRNA] |
CTD |
PMID:28153600 |
|
NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
|
|
G |
Txnrd1 |
thioredoxin reductase 1 |
multiple interactions |
EXP |
Glutathione affects the reaction [arsenic trioxide results in decreased activity of TXNRD1 protein]; Glutathione inhibits the reaction [[Mitomycin co-treated with NADP] results in decreased activity of TXNRD1 protein]; Glutathione inhibits the reaction [N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein] |
CTD |
PMID:17640917 PMID:22694104 PMID:24661219 |
|
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
|
|
G |
Tyr |
tyrosinase |
multiple interactions |
ISO |
[TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Glutathione; [TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of 3-phenylpropionic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of Chlorogenic Acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of cinnamic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of ferulic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of p-coumaric acid] which results in decreased abundance of Glutathione; Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid]; Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD]; Glutathione inhibits the reaction [TYR protein results in increased oxidation of caffeic acid phenethyl ester] |
CTD |
PMID:20685355 |
|
NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
|
|
G |
Uchl1 |
ubiquitin C-terminal hydrolase L1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [1,2-naphthoquinone results in increased metabolism of and results in decreased activity of UCHL1 protein] |
CTD |
PMID:24582816 |
|
NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590
|
|
G |
Ucp1 |
uncoupling protein 1 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [alitretinoin results in increased expression of UCP1 mRNA]; Glutathione inhibits the reaction [rosiglitazone results in increased expression of UCP1 mRNA] |
CTD |
PMID:12414803 |
|
NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
|
|
G |
Ucp2 |
uncoupling protein 2 |
multiple interactions |
EXP |
Glutathione inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide] |
CTD |
PMID:19361538 |
|
NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
|
|
G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UGT1A2 mRNA; Glutathione deficiency results in increased expression of UGT1A3 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
G |
Ugt1a3 |
UDP glycosyltransferase 1 family, polypeptide A3 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UGT1A5 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UGT1A6 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
G |
Ugt1a7c |
UDP glucuronosyltransferase 1 family, polypeptide A7C |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UGT1A10 mRNA; Glutathione deficiency results in increased expression of UGT1A7 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
G |
Ugt1a8 |
UDP glucuronosyltransferase family 1 member A8 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UGT1A8 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
G |
Ugt2b1 |
UDP glucuronosyltransferase 2 family, polypeptide B1 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UGT2B1 mRNA; Glutathione deficiency results in increased expression of UGT2B4 mRNA |
CTD |
PMID:15345336 |
|
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
|
|
G |
UST4r |
integral membrane transport protein UST4r |
increases expression |
EXP |
Glutathione deficiency results in increased expression of UST4R mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 1:205,072,204...205,142,718
Ensembl chr 1:205,072,296...205,142,691
|
|
G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
[[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] |
CTD |
PMID:16271621 PMID:21971136 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
Glutathione inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA] |
CTD |
PMID:11641398 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
G |
Vnn1 |
vanin 1 |
affects abundance |
ISO |
VNN1 affects the abundance of Glutathione |
CTD |
PMID:15282320 |
|
NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
|
|
G |
Xbp1 |
X-box binding protein 1 |
multiple interactions |
ISO |
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of XBP1 protein alternative form]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of XBP1 protein alternative form] |
CTD |
PMID:24515801 |
|
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
|
|
G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
EXP |
[Xanthine co-treated with XDH protein] results in increased abundance of Glutathione |
CTD |
PMID:7743507 |
|
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
|
|
G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions |
ISO |
Glutathione inhibits the reaction [Thimerosal results in decreased expression of XIAP protein] Glutathione inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of XIAP protein] |
CTD |
PMID:12140745 PMID:36689145 |
|
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
|
|
G |
Xk |
X-linked Kx blood group antigen, Kell and VPS13A binding protein |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of XK mRNA |
CTD |
PMID:20621112 |
|
NCBI chr X:13,436,412...13,472,830
Ensembl chr X:13,436,418...13,472,830
|
|
G |
Xrcc1 |
X-ray repair cross complementing 1 |
multiple interactions increases oxidation decreases oxidation |
ISO |
Acetylcysteine promotes the reaction [XRCC1 protein results in decreased oxidation of Glutathione] XRCC1 gene mutant form results in increased oxidation of Glutathione |
CTD |
PMID:30998386 |
|
NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
|
|
G |
Ywhag |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma |
increases expression |
EXP |
Glutathione deficiency results in increased expression of YWHAG mRNA |
CTD |
PMID:15345336 |
|
NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827
|
|
G |
Zbtb7b |
zinc finger and BTB domain containing 7B |
decreases expression |
EXP |
Glutathione deficiency results in decreased expression of ZBTB7B mRNA |
CTD |
PMID:20621112 |
|
NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
|
|
G |
Zfp367 |
zinc finger protein 367 |
increases expression |
EXP |
Glutathione deficiency results in increased expression of ZFP367 mRNA |
CTD |
PMID:20621112 |
|
NCBI chr17:965,161...984,290
Ensembl chr17:965,161...984,287
|
|
|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
increases export increases activity multiple interactions |
ISO EXP |
ABCC1 protein results in increased export of Glutathione Disulfide Glutathione Disulfide results in increased activity of ABCC1 protein [Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide Glutathione Disulfide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; Glutathione Disulfide promotes the reaction [Leukotriene C4 analog binds to ABCC1 protein] ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione Disulfide] |
CTD |
PMID:11306701 PMID:15628876 PMID:17272743 PMID:19053318 PMID:21918036 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases transport multiple interactions |
EXP |
ABCC2 protein results in increased transport of Glutathione Disulfide Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of Glutathione Disulfide] |
CTD |
PMID:15276087 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
|
|
G |
Agt |
angiotensinogen |
multiple interactions increases export decreases abundance |
ISO |
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione Disulfide] AGT protein results in increased export of Glutathione Disulfide |
CTD |
PMID:17272743 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Alox12 |
arachidonate 12-lipoxygenase, 12S type |
affects response to substance increases glutathionylation increases activity |
ISO |
ALOX12 protein affects the susceptibility to Glutathione Disulfide Glutathione Disulfide results in increased glutathionylation of ALOX12 protein Glutathione Disulfide results in increased activity of ALOX12 protein |
CTD |
PMID:19373248 |
|
NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
|
|
G |
Ar |
androgen receptor |
affects localization multiple interactions |
ISO |
Glutathione Disulfide affects the localization of AR protein Glutathione Disulfide binds to and results in increased activity of AR protein |
CTD |
PMID:28478275 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
Glutathione Disulfide results in increased expression of CDKN1A protein |
CTD |
PMID:15993333 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cftr |
CF transmembrane conductance regulator |
decreases activity |
ISO |
Glutathione Disulfide results in decreased activity of CFTR protein |
CTD |
PMID:15657297 |
|
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
|
|
G |
Crygd |
crystallin, gamma D |
increases oxidation |
ISO |
Glutathione Disulfide results in increased oxidation of CRYGD protein mutant form |
CTD |
PMID:30242128 |
|
NCBI chr 9:66,442,057...66,443,668
Ensembl chr 9:66,442,054...66,444,067
|
|
G |
Fas |
Fas cell surface death receptor |
decreases activity |
ISO |
Glutathione Disulfide results in decreased activity of FAS protein |
CTD |
PMID:10385654 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
|
|
G |
Fndc5 |
fibronectin type III domain containing 5 |
decreases abundance |
EXP |
FNDC5 protein results in decreased abundance of Glutathione Disulfide |
CTD |
PMID:32165127 |
|
NCBI chr 5:141,481,593...141,491,257
Ensembl chr 5:141,481,590...141,490,731
|
|
G |
Glrx |
glutaredoxin |
affects response to substance |
ISO |
GLRX protein affects the susceptibility to Glutathione Disulfide |
CTD |
PMID:19373248 |
|
NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO EXP |
Glutathione Disulfide inhibits the reaction [Carmustine results in decreased activity of GSR protein] arsenic trioxide inhibits the reaction [GSR protein results in increased reduction of Glutathione Disulfide]; arsenic trioxide promotes the reaction [GSR protein binds to Glutathione Disulfide]; GSR protein binds to and results in increased reduction of Glutathione Disulfide [[Carmustine results in decreased activity of GSR protein] which co-treated with Oligodeoxyribonucleotides analog] results in increased abundance of Glutathione Disulfide; [[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione Disulfide |
CTD |
PMID:12114195 PMID:12477282 PMID:19668867 PMID:24634002 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
Glutathione Disulfide analog promotes the reaction [cobaltous chloride results in increased activity of HIF1A protein]; Glutathione Disulfide analog promotes the reaction [Oxygen deficiency results in increased activity of HIF1A protein] |
CTD |
PMID:19374849 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
[MPO protein results in increased oxidation of Phenolsulfonphthalein] which results in increased abundance of Glutathione Disulfide |
CTD |
PMID:31288001 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO EXP |
Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to RELA protein]] Glutathione Disulfide results in decreased activity of [NFKB1 protein binds to RELA protein] |
CTD |
PMID:12433058 PMID:12477282 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
|
|
G |
Ngf |
nerve growth factor |
affects abundance |
ISO |
NGF protein affects the abundance of Glutathione Disulfide |
CTD |
PMID:23472850 |
|
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
|
|
G |
Nnmt |
nicotinamide N-methyltransferase |
increases abundance |
ISO |
NNMT protein results in increased abundance of Glutathione Disulfide |
CTD |
PMID:31909875 |
|
NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to RELA protein]] Glutathione Disulfide results in decreased activity of [NFKB1 protein binds to RELA protein] |
CTD |
PMID:12433058 PMID:12477282 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions increases abundance |
ISO |
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [SLC2A4 gene mutant form results in increased abundance of Glutathione Disulfide] |
CTD |
PMID:22221582 |
|
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
|
|
G |
Snca |
synuclein alpha |
decreases abundance |
ISO |
SNCA protein results in decreased abundance of Glutathione Disulfide |
CTD |
PMID:27424009 |
|
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
|
|
G |
Sod2 |
superoxide dismutase 2 |
increases abundance |
ISO |
SOD2 protein results in increased abundance of Glutathione Disulfide |
CTD |
PMID:15130278 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sult1a1 |
sulfotransferase family 1A member 1 |
multiple interactions |
EXP |
Glutathione Disulfide affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog binds to SULT1A1 protein] |
CTD |
PMID:21130751 |
|
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions increases glutathionylation |
ISO |
Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Glutathione Disulfide results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein |
CTD |
PMID:15993333 PMID:17555331 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
|
G |
Camk2a |
calcium/calmodulin-dependent protein kinase II alpha |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
|
|
G |
Cartpt |
CART prepropeptide |
multiple interactions |
EXP |
S-ethyl glutathione inhibits the reaction [Amphetamine results in decreased expression of CARTPT protein]; S-ethyl glutathione inhibits the reaction [Amphetamine results in increased expression of CARTPT mRNA] |
CTD |
PMID:25825358 |
|
NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
|
|
G |
Cat |
catalase |
multiple interactions |
EXP |
S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of CAT mRNA] |
CTD |
PMID:24792324 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Cav1 |
caveolin 1 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased phosphorylation of CAV1 protein] |
CTD |
PMID:35349355 |
|
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
|
|
G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]] |
CTD |
PMID:25619640 |
|
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
|
|
G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CXCL12 mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [[CYP2E1 protein co-treated with Paraquat] results in increased expression of KLF6 protein]; S-ethyl glutathione inhibits the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein]; S-ethyl glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene] |
CTD |
PMID:16872732 PMID:22486562 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [Benzo(a)pyrene results in decreased expression of ESR1 protein] |
CTD |
PMID:26149760 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
Fgf18 |
fibroblast growth factor 18 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818
|
|
G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
[S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA] |
CTD |
PMID:19524604 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
|
|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
EXP |
S-ethyl glutathione inhibits the reaction [Cadmium Chloride results in increased expression of G6PD mRNA]; S-ethyl glutathione inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA] |
CTD |
PMID:12717738 PMID:15225644 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA] |
CTD |
PMID:17980396 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation multiple interactions |
ISO |
S-ethyl glutathione results in increased phosphorylation of GSK3B protein S-ethyl glutathione inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein] |
CTD |
PMID:25246272 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
|
|
G |
Gss |
glutathione synthetase |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
|
|
G |
Gsta1 |
glutathione S-transferase alpha 1 |
multiple interactions |
EXP |
S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of GSTA1 mRNA] |
CTD |
PMID:24792324 |
|
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
|
|
G |
Gsta5 |
glutathione S-transferase alpha 5 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA1 mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [Fenretinide results in increased expression of HMOX1 protein] |
CTD |
PMID:25246272 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Il2 |
interleukin 2 |
increases expression |
ISO |
S-ethyl glutathione results in increased expression of IL2 protein |
CTD |
PMID:7632946 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
|
|
G |
Il4 |
interleukin 4 |
multiple interactions |
EXP |
S-ethyl glutathione inhibits the reaction [Mercuric Chloride results in increased expression of IL4 mRNA]; S-ethyl glutathione inhibits the reaction [Mercuric Chloride results in increased expression of IL4 protein] |
CTD |
PMID:11222498 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
|
|
G |
Klf6 |
KLF transcription factor 6 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [[CYP2E1 protein co-treated with Paraquat] results in increased expression of KLF6 protein]; S-ethyl glutathione inhibits the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein] |
CTD |
PMID:22486562 |
|
NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
|
|
G |
Lox |
lysyl oxidase |
decreases expression decreases activity |
EXP |
S-ethyl glutathione results in decreased expression of LOX mRNA S-ethyl glutathione results in decreased activity of LOX protein |
CTD |
PMID:19879314 |
|
NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK1 protein] S-ethyl glutathione inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24307199 PMID:24814887 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK3 protein] S-ethyl glutathione inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24307199 PMID:24814887 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA] |
CTD |
PMID:17980396 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
S-ethyl glutathione inhibits the reaction [Acetaminophen inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]] S-ethyl glutathione inhibits the reaction [Potassium Cyanide results in increased expression of NOS2 protein] |
CTD |
PMID:12774022 PMID:16933320 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Npy |
neuropeptide Y |
multiple interactions |
EXP |
S-ethyl glutathione inhibits the reaction [Amphetamine results in decreased expression of NPY mRNA]; S-ethyl glutathione inhibits the reaction [Amphetamine results in decreased expression of NPY protein]; S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY mRNA] |
CTD |
PMID:24792324 PMID:25825358 |
|
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
|
|
G |
Nr2e3 |
nuclear receptor subfamily 2, group E, member 3 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [Benzo(a)pyrene results in decreased expression of NR2E3 protein] |
CTD |
PMID:26149760 |
|
NCBI chr 8:60,365,581...60,373,383
Ensembl chr 8:60,366,124...60,373,163
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [wedelolactone results in increased cleavage of PARP1 protein] |
CTD |
PMID:22733624 PMID:25246272 PMID:25619640 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Pax3 |
paired box 3 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [Glucose results in decreased expression of PAX3 mRNA] |
CTD |
PMID:12739027 |
|
NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042
|
|
G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
|
|
G |
Pomc |
proopiomelanocortin |
multiple interactions |
EXP |
S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of POMC mRNA] |
CTD |
PMID:24792324 |
|
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [Buthionine Sulfoximine results in increased expression of PPARG mRNA] |
CTD |
PMID:21520053 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of SOD1 mRNA] |
CTD |
PMID:24792324 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP |
S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of STAT3 mRNA] |
CTD |
PMID:24792324 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
G |
Tgfb2 |
transforming growth factor, beta 2 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA] |
CTD |
PMID:24814887 |
|
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [Acetaminophen inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]] |
CTD |
PMID:12774022 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] |
CTD |
PMID:25619640 |
|
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
S-ethyl glutathione inhibits the reaction [Camptothecin results in increased expression of TP53 protein modified form]; S-ethyl glutathione inhibits the reaction [tert-Butylhydroperoxide results in increased expression of TP53 protein modified form] |
CTD |
PMID:17555331 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
glycyl-histidyl-lysine inhibits the reaction [TNF protein results in increased secretion of IL6 protein] |
CTD |
PMID:23285694 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
EXP |
[glycyl-histidyl-lysine co-treated with Copper] results in increased expression of MMP2 mRNA; [glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of MMP2 protein |
CTD |
PMID:11045606 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
|
|
G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
EXP |
[glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of TIMP1 protein |
CTD |
PMID:11045606 |
|
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
|
|
G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
multiple interactions |
EXP |
[glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of TIMP2 protein |
CTD |
PMID:11045606 |
|
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
glycyl-histidyl-lysine inhibits the reaction [TNF protein results in increased secretion of IL6 protein] |
CTD |
PMID:23285694 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Nox1 |
NADPH oxidase 1 |
multiple interactions |
ISO |
1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]]; NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]] |
CTD |
PMID:24912985 |
|
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
|
|
|
G |
Slc15a1 |
solute carrier family 15 member 1 |
multiple interactions decreases activity increases uptake affects transport |
ISO EXP |
[Zinc results in decreased activity of SLC15A1 protein] which results in decreased uptake of glycylsarcosine; benazepril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]; Cilazapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]; Fosinopril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]; glycylsarcosine inhibits the reaction [SLC15A1 protein results in increased transport of Lisdexamfetamine Dimesylate]; moexipril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]; Perindopril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]; Quinapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]; quinaprilat inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]; Ramipril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]; spirapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]; trandolapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] glycylsarcosine results in decreased activity of SLC15A1 protein SLC15A1 protein affects the transport of glycylsarcosine |
CTD |
PMID:14567632 PMID:18713951 PMID:20628632 PMID:21240898 PMID:21341280 PMID:33007874 More...
|
|
NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
|
|
G |
Slc15a2 |
solute carrier family 15 member 2 |
multiple interactions increases uptake |
ISO EXP |
benazepril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]; Enalapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]; Quinapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]; quinaprilat inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]; spirapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] benazepril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]; Cilazapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]; Fosinopril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]; moexipril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]; Perindopril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]; Quinapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]; quinaprilat inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]; Ramipril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]; spirapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]; trandolapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] |
CTD |
PMID:18713951 PMID:33007874 |
|
NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
|
|
|
G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gonadotropin-Releasing Hormone results in decreased expression of ESR1 protein]; Gonadotropin-Releasing Hormone results in increased ubiquitination of and results in increased degradation of and results in decreased expression of ESR1 protein |
CTD |
PMID:16055746 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
Ube2d2 |
ubiquitin-conjugating enzyme E2D 2 |
increases expression |
ISO |
Gonadotropin-Releasing Hormone results in increased expression of UBE2D2 mRNA; Gonadotropin-Releasing Hormone results in increased expression of UBE2D2 protein |
CTD |
PMID:16055746 |
|
NCBI chr18:27,364,325...27,406,322
Ensembl chr18:27,364,303...27,406,181
|
|
|
G |
Ace |
angiotensin I converting enzyme |
increases expression decreases expression multiple interactions |
ISO |
goralatide results in increased expression of ACE mRNA goralatide results in decreased expression of ACE mRNA [BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA] |
CTD |
PMID:20096676 PMID:33007385 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
|
|
G |
Ace2 |
angiotensin converting enzyme 2 |
multiple interactions |
ISO |
ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein] |
CTD |
PMID:33007385 |
|
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO EXP |
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein] [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein] goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein] |
CTD |
PMID:31181250 PMID:33007385 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
|
|
G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]]; goralatide inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; goralatide inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; goralatide inhibits the reaction [AGT protein results in increased expression of ACE protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of AGT protein]; goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of VIM protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SHH protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein] |
CTD |
PMID:31181250 PMID:33007385 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
ISO |
ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein] |
CTD |
PMID:33007385 |
|
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
|
|
G |
Bdkrb1 |
bradykinin receptor B1 |
affects abundance multiple interactions |
ISO |
BDKRB1 protein affects the abundance of goralatide [BDKRB1 protein affects the activity of ACE protein] which affects the hydrolysis of goralatide |
CTD |
PMID:20096676 |
|
NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
|
|
G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] |
CTD |
PMID:33007385 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
|
|
G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein] |
CTD |
PMID:33007385 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
|
|
G |
Gli1 |
GLI family zinc finger 1 |
multiple interactions |
ISO EXP |
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI1 protein] [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein] |
CTD |
PMID:31181250 |
|
NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
|
|
G |
Gli2 |
GLI family zinc finger 2 |
multiple interactions |
ISO EXP |
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; goralatide inhibits the reaction [AGT protein results in increased expression of GLI2 protein] [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein] |
CTD |
PMID:31181250 |
|
NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
|
|
G |
Gli3 |
GLI family zinc finger 3 |
multiple interactions |
EXP ISO |
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of GLI3 protein] |
CTD |
PMID:31181250 |
|
NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
|
|
G |
Mas1 |
MAS1 proto-oncogene, G protein-coupled receptor |
multiple interactions |
ISO |
ACE2 protein affects the reaction [goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]]; goralatide inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] |
CTD |
PMID:33007385 |
|
NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
|
|
G |
Ptch1 |
patched 1 |
multiple interactions |
EXP ISO |
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein] |
CTD |
PMID:31181250 |
|
NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
|
|
G |
Shh |
sonic hedgehog signaling molecule |
multiple interactions |
ISO EXP |
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SHH protein] [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein] |
CTD |
PMID:31181250 |
|
NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
|
|
G |
Smo |
smoothened, frizzled class receptor |
multiple interactions |
EXP ISO |
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein] [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; goralatide inhibits the reaction [AGT protein results in increased expression of SMO protein] |
CTD |
PMID:31181250 |
|
NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
|
|
G |
Vim |
vimentin |
multiple interactions |
ISO |
goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide inhibits the reaction [AGT protein results in increased expression of VIM protein]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] |
CTD |
PMID:33007385 |
|
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
|
|
|
G |
Gldc |
glycine decarboxylase |
increases expression |
ISO |
HC toxin results in increased expression of GLDC mRNA |
CTD |
PMID:33770205 |
|
NCBI chr 1:227,883,249...227,962,119
Ensembl chr 1:227,883,249...227,962,097
|
|
G |
Gpr183 |
G protein-coupled receptor 183 |
decreases expression |
ISO |
HC toxin results in decreased expression of GPR183 mRNA |
CTD |
PMID:33770205 |
|
NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559
|
|
G |
Idi1 |
isopentenyl-diphosphate delta isomerase 1 |
increases expression |
ISO |
HC toxin results in increased expression of IDI1 mRNA |
CTD |
PMID:33770205 |
|
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
|
|
G |
Klhl42 |
kelch-like family, member 42 |
decreases expression |
ISO |
HC toxin results in decreased expression of KLHL42 mRNA |
CTD |
PMID:33770205 |
|
NCBI chr 4:179,999,655...180,027,283
Ensembl chr 4:180,004,580...180,027,283
|
|
G |
Mepce |
methylphosphate capping enzyme |
decreases expression |
ISO |
HC toxin results in decreased expression of MEPCE mRNA |
CTD |
PMID:33770205 |
|
NCBI chr12:18,911,796...18,916,515
Ensembl chr12:18,911,796...18,916,514
|
|
G |
Nrros |
negative regulator of reactive oxygen species |
decreases expression |
ISO |
HC toxin results in decreased expression of NRROS mRNA |
CTD |
PMID:33770205 |
|
NCBI chr11:68,628,641...68,646,152
Ensembl chr11:68,628,712...68,646,142
|
|
G |
Ppil1 |
peptidylprolyl isomerase like 1 |
decreases expression |
ISO |
HC toxin results in decreased expression of PPIL1 mRNA |
CTD |
PMID:33770205 |
|
NCBI chr20:7,302,292...7,322,349
Ensembl chr20:7,302,621...7,322,354
|
|
G |
Srgap3 |
SLIT-ROBO Rho GTPase activating protein 3 |
increases expression |
ISO |
HC toxin results in increased expression of SRGAP3 mRNA |
CTD |
PMID:33770205 |
|
NCBI chr 4:145,839,369...146,070,556
Ensembl chr 4:145,840,078...146,070,575
|
|
G |
Tmcc2 |
transmembrane and coiled-coil domain family 2 |
increases expression |
ISO |
HC toxin results in increased expression of TMCC2 mRNA |
CTD |
PMID:33770205 |
|
NCBI chr13:43,794,029...43,831,716
Ensembl chr13:43,794,029...43,831,716
|
|
G |
Tubb2a |
tubulin, beta 2A class IIa |
increases expression |
ISO |
HC toxin results in increased expression of TUBB2A mRNA |
CTD |
PMID:33770205 |
|
NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714
|
|
G |
Yes1 |
YES proto-oncogene 1, Src family tyrosine kinase |
increases expression |
ISO |
HC toxin results in increased expression of YES1 mRNA |
CTD |
PMID:33770205 |
|
NCBI chr 9:113,200,256...113,275,942
Ensembl chr 9:113,200,256...113,299,837
|
|
|
G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of AGT protein] |
CTD |
PMID:38027817 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Bdkrb2 |
bradykinin receptor B2 |
multiple interactions |
ISO EXP |
icatibant binds to and results in decreased activity of BDKRB2 protein; icatibant inhibits the reaction [FR 190997 binds to and results in increased activity of BDKRB2 protein]; icatibant inhibits the reaction [KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein] icatibant binds to and results in decreased activity of BDKRB2 protein; icatibant inhibits the reaction [KNG1 protein modified form binds to BDKRB2 protein] [icatibant binds to and results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Chondroitin Sulfates; [icatibant binds to and results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Streptozocin; [icatibant binds to and results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Vincristine; [icatibant results in decreased activity of BDKRB2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to benazepril; [icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Valsartan; icatibant binds to and results in decreased activity of BDKRB2 protein; icatibant inhibits the reaction [[KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein] which results in increased abundance of Inositol Phosphates] |
CTD |
PMID:10666510 PMID:12727271 PMID:15140628 PMID:16982965 PMID:17347322 PMID:17989505 PMID:21436127 PMID:24975837 PMID:30685357 More...
|
|
NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
EXP |
icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of ICAM1 protein]] |
CTD |
PMID:16401625 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of IL6 protein] |
CTD |
PMID:38027817 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Klk1 |
kallikrein 1 |
multiple interactions |
EXP |
icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of ICAM1 protein]]; icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of TGFB1 protein]]; icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased phosphorylation of MAPK8 protein]]; icatibant inhibits the reaction [KLK1 protein results in increased abundance of Nitric Oxide] |
CTD |
PMID:16401625 |
|
NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754
|
|
G |
Kng1 |
kininogen 1 |
multiple interactions decreases activity |
ISO EXP |
icatibant inhibits the reaction [KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein] icatibant inhibits the reaction [KNG1 protein modified form binds to BDKRB2 protein] icatibant results in decreased activity of KNG1 [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of KNG1 protein]; icatibant inhibits the reaction [[KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein] which results in increased abundance of Inositol Phosphates]; icatibant inhibits the reaction [KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]]; icatibant inhibits the reaction [KNG1 results in increased expression of PTGS2 mRNA]; icatibant inhibits the reaction [KNG1 results in increased secretion of TAC1 protein] |
CTD |
PMID:1334751 PMID:15140628 PMID:15750287 PMID:16696851 PMID:17347322 PMID:22198006 PMID:30685357 PMID:38027817 More...
|
|
NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
increases activity multiple interactions |
ISO |
icatibant results in increased activity of MAPK3 protein FR 173657 inhibits the reaction [icatibant results in increased activity of MAPK3 protein] |
CTD |
PMID:11139431 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased phosphorylation of MAPK8 protein]] |
CTD |
PMID:16401625 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Plat |
plasminogen activator, tissue type |
decreases expression |
ISO |
icatibant results in decreased expression of PLAT protein |
CTD |
PMID:16321614 |
|
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
icatibant inhibits the reaction [KNG1 results in increased expression of PTGS2 mRNA] |
CTD |
PMID:15750287 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Tac1 |
tachykinin, precursor 1 |
multiple interactions |
EXP |
icatibant inhibits the reaction [KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]]; icatibant inhibits the reaction [KNG1 results in increased secretion of TAC1 protein] |
CTD |
PMID:16696851 PMID:22198006 |
|
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of TGFB1 protein]] |
CTD |
PMID:16401625 PMID:38027817 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of TNF protein] |
CTD |
PMID:38027817 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Ace2 |
angiotensin converting enzyme 2 |
increases response to substance |
ISO |
ACE2 gene SNP results in increased susceptibility to imidapril |
CTD |
PMID:27121444 |
|
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
|
|
G |
Ces1d |
carboxylesterase 1D |
multiple interactions |
ISO |
CES1 protein results in increased hydrolysis of and results in increased activity of imidapril; CES1 protein results in increased metabolism of and results in increased activity of imidapril; Dust inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril]; tert-butylphenyl diphenyl phosphate inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril]; triphenyl phosphate inhibits the reaction [CES1 protein results in increased metabolism of and results in increased activity of imidapril] |
CTD |
PMID:9300133 PMID:31268531 |
|
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
|
|
G |
Cyp11b3 |
cytochrome P450, family 11, subfamily b, polypeptide 3 |
affects response to substance |
ISO |
CYP11B2 gene polymorphism affects the susceptibility to imidapril |
CTD |
PMID:16765146 |
|
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
|
|
|
G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
imidaprilat inhibits the reaction [AGT protein results in increased activity of and results in increased localization of PRKCA protein] |
CTD |
PMID:16257180 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Prkca |
protein kinase C, alpha |
multiple interactions |
ISO |
imidaprilat inhibits the reaction [AGT protein results in increased activity of and results in increased localization of PRKCA protein] |
CTD |
PMID:16257180 |
|
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
|
|
|
G |
Aif1 |
allograft inflammatory factor 1 |
multiple interactions |
ISO |
gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of AIF1 protein] |
CTD |
PMID:35714925 |
|
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:34767868 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein] |
CTD |
PMID:34767868 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP |
gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein] |
CTD |
PMID:34767868 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
AKT activator SC79 inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]]; Anisomycin inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein] |
CTD |
PMID:34767868 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
AKT activator SC79 inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein]]; Anisomycin inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein]]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein] |
CTD |
PMID:34767868 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cat |
catalase |
multiple interactions |
EXP |
gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein] |
CTD |
PMID:34767868 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased phosphorylation of CHUK protein] |
CTD |
PMID:35714925 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
|
|
G |
Cycs |
cytochrome c, somatic |
multiple interactions |
EXP |
gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CYCS protein] |
CTD |
PMID:34767868 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases chemical synthesis |
EXP |
Buthionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]; Cysteine promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]; Excitatory Amino Acid Agents promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine] |
CTD |
PMID:15115889 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased secretion of IL1B protein]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased secretion of IL1B protein]] |
CTD |
PMID:35714925 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Map2k7 |
mitogen activated protein kinase kinase 7 |
multiple interactions |
EXP |
gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAP2K7 protein] |
CTD |
PMID:34767868 |
|
NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:34767868 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:35714925 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) promotes the reaction [RELA protein binds to NOS2 promoter]]; gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of NOS2 protein]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) promotes the reaction [RELA protein binds to NOS2 promoter]]]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of NOS2 protein]] |
CTD |
PMID:35714925 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
multiple interactions |
ISO |
gamma-glutamylcysteine promotes the reaction [amyloid beta-protein (1-42) results in increased expression of NR4A2 mRNA]; gamma-glutamylcysteine promotes the reaction [amyloid beta-protein (1-42) results in increased expression of NR4A2 protein]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) promotes the reaction [RELA protein binds to NOS2 promoter]]]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of NOS2 protein]]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of PTGS2 protein]]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased secretion of IL1B protein]]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased secretion of TNF protein]] |
CTD |
PMID:35714925 |
|
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
EXP |
AKT activator SC79 inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]]; Anisomycin inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein] |
CTD |
PMID:34767868 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of PTGS2 protein]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of PTGS2 protein]] |
CTD |
PMID:35714925 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) promotes the reaction [RELA protein binds to NOS2 promoter]]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) promotes the reaction [RELA protein binds to NOS2 promoter]]] |
CTD |
PMID:35714925 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased secretion of TNF protein]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased secretion of TNF protein]] |
CTD |
PMID:35714925 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with lanreotide] results in increased activity of CASP3 protein |
CTD |
PMID:19874807 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
EXP |
lanreotide promotes the reaction [Diethylnitrosamine results in increased expression of CDKN1A mRNA] |
CTD |
PMID:19874807 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
multiple interactions |
EXP |
lanreotide inhibits the reaction [Diethylnitrosamine results in increased expression of FLT1 mRNA] |
CTD |
PMID:19874807 |
|
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP |
lanreotide inhibits the reaction [Diethylnitrosamine results in increased expression of NFKB1 protein] |
CTD |
PMID:19874807 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
|
|
G |
Sstr2 |
somatostatin receptor 2 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with lanreotide] results in increased expression of SSTR2 mRNA |
CTD |
PMID:19874807 |
|
NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351
|
|
G |
Sstr3 |
somatostatin receptor 3 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with lanreotide] results in increased expression of SSTR3 mRNA |
CTD |
PMID:19874807 |
|
NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769
|
|
G |
Sstr5 |
somatostatin receptor 5 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with lanreotide] results in increased expression of SSTR5 mRNA |
CTD |
PMID:19874807 |
|
NCBI chr10:14,506,868...14,512,946
Ensembl chr10:14,506,868...14,512,946
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
lanreotide inhibits the reaction [Diethylnitrosamine results in increased expression of TP53 mRNA] |
CTD |
PMID:19874807 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
|
G |
Dpp3 |
dipeptidylpeptidase 3 |
increases cleavage multiple interactions |
ISO |
DPP3 protein results in increased cleavage of Enkephalin, Leucine spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine] |
CTD |
PMID:10873616 |
|
NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
|
|
G |
Oprd1 |
opioid receptor, delta 1 |
increases activity |
ISO |
Enkephalin, Leucine results in increased activity of OPRD1 protein |
CTD |
PMID:26476280 |
|
NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
|
|
G |
Oprm1 |
opioid receptor, mu 1 |
increases activity |
ISO |
Enkephalin, Leucine results in increased activity of OPRM1 protein |
CTD |
PMID:26476280 |
|
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
|
|
|
G |
Alox5 |
arachidonate 5-lipoxygenase |
increases abundance multiple interactions |
ISO |
ALOX5 protein results in increased abundance of Leukotriene D4 ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]] [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene D4 |
CTD |
PMID:10764316 PMID:12629151 PMID:12794006 |
|
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
|
|
G |
Arrb1 |
arrestin, beta 1 |
multiple interactions |
ISO |
Leukotriene D4 promotes the reaction [CYSLTR2 protein binds to ARRB1 protein] |
CTD |
PMID:33288675 |
|
NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
|
|
G |
Arrb2 |
arrestin, beta 2 |
multiple interactions |
ISO |
Leukotriene D4 promotes the reaction [CYSLTR2 protein binds to ARRB2 protein] |
CTD |
PMID:33288675 |
|
NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
|
|
G |
Csf2 |
colony stimulating factor 2 |
multiple interactions |
ISO |
Leukotriene D4 promotes the reaction [CSF2 protein results in increased expression of TGFB1 protein] |
CTD |
PMID:15947480 |
|
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
|
|
G |
Cysltr1 |
cysteinyl leukotriene receptor 1 |
multiple interactions affects binding increases activity increases response to substance |
ISO |
[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; [Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; [Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein; [Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein; [Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein; alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; BAY u9773 inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; BAY u9773 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; BAY u9773 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; CGP 57698 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; CYSLTR1 protein promotes the reaction [Leukotriene D4 results in increased abundance of Calcium]; iralukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein; LY 171883 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; MEN91507 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; montelukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; montelukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; montelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; pobilukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; pobilukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; pobilukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; pranlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; pranlukast inhibits the reaction [CYSLTR1 protein results in increased susceptibility to Leukotriene D4]; pranlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; pranlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; verlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; verlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; zafirlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein]; zafirlukast inhibits the reaction [CYSLTR1 protein promotes the reaction [Leukotriene D4 results in increased abundance of Calcium]]; zafirlukast inhibits the reaction [CYSLTR1 protein results in increased susceptibility to Leukotriene D4]; zafirlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein] [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; CYSLTR1 protein binds to and affects the susceptibility to Leukotriene D4; Leukotriene C4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein; Leukotriene E4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; pranlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein] |
CTD |
PMID:8014876 PMID:8384568 PMID:9620942 PMID:9647482 PMID:10391245 PMID:10462554 PMID:10825389 PMID:11093801 PMID:11705452 PMID:11932261 PMID:11996896 PMID:12853847 PMID:14718577 PMID:15792791 PMID:15990778 PMID:18651869 PMID:18704935 PMID:20083671 More...
|
|
NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121
|
|
G |
Cysltr2 |
cysteinyl leukotriene receptor 2 |
multiple interactions |
ISO |
[Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; [Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein] which results in increased chemical synthesis of inositol 1-phosphate; [Leukotriene D4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; BAY u9773 inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium]; Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein; Leukotriene D4 promotes the reaction [CYSLTR2 protein binds to ARRB1 protein]; Leukotriene D4 promotes the reaction [CYSLTR2 protein binds to ARRB2 protein]; montelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein]; pranlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein]; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein]; zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein] |
CTD |
PMID:10851239 PMID:11093801 PMID:33288675 |
|
NCBI chr15:48,189,476...48,228,750
Ensembl chr15:48,189,073...48,304,136
|
|
G |
Fas |
Fas cell surface death receptor |
decreases expression |
ISO |
Leukotriene D4 results in decreased expression of FAS protein |
CTD |
PMID:15990778 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
|
|
G |
Gpr17 |
G protein-coupled receptor 17 |
increases activity multiple interactions |
ISO |
Leukotriene D4 results in increased activity of GPR17 protein montelukast inhibits the reaction [Leukotriene D4 results in increased activity of GPR17 protein] |
CTD |
PMID:18974869 |
|
NCBI chr18:23,576,232...23,583,153
Ensembl chr18:23,577,242...23,582,966
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
Leukotriene D4 promotes the reaction [ICAM1 protein results in increased expression of TGFB1 protein] |
CTD |
PMID:15947480 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
BAY u9773 inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]; Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]; montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]; zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:19118273 |
|
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
|
|
G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
BAY u9773 inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]; Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]; montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]; zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:19118273 |
|
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
|
|
G |
Il13 |
interleukin 13 |
increases abundance multiple interactions |
EXP |
IL13 protein results in increased abundance of Leukotriene D4 [IL13 protein results in increased abundance of Leukotriene D4] which results in increased secretion of MUC5AC protein |
CTD |
PMID:12654629 |
|
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
|
|
G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
Leukotriene D4 promotes the reaction [IL5 protein results in increased expression of TGFB1 protein] |
CTD |
PMID:15947480 |
|
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
|
|
G |
Il6 |
interleukin 6 |
multiple interactions increases secretion |
ISO |
[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein; BAY u9773 inhibits the reaction [Leukotriene D4 results in increased secretion of IL6 protein]; montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of IL6 protein]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein]; zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of IL6 protein] |
CTD |
PMID:18704935 PMID:19118273 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
Leukotriene D4 results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:19837106 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
Leukotriene D4 results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:19837106 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mgst1 |
microsomal glutathione S-transferase 1 |
decreases activity |
EXP |
Leukotriene D4 results in decreased activity of MGST1 protein |
CTD |
PMID:9890956 |
|
NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Leukotriene D4 results in increased expression of MMP9 protein]; SB 203580 inhibits the reaction [Leukotriene D4 results in increased expression of MMP9 protein] |
CTD |
PMID:19837106 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
multiple interactions increases expression |
EXP |
[IL13 protein results in increased abundance of Leukotriene D4] which results in increased secretion of MUC5AC protein; verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC mRNA]; verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC protein] Leukotriene D4 results in increased expression of MUC5AC mRNA; Leukotriene D4 results in increased expression of MUC5AC protein |
CTD |
PMID:12654629 |
|
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
|
|
G |
Pdgfrb |
platelet derived growth factor receptor beta |
multiple interactions |
ISO |
6,7-dimethoxy-3-phenylquinoxaline inhibits the reaction [Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein]; bisindolylmaleimide I inhibits the reaction [Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein]; Leukotriene D4 promotes the reaction [SRC protein binds to PDGFRB protein]; Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein; lipoxin A4 inhibits the reaction [Leukotriene D4 results in increased activity of PDGFRB protein]; pobilukast inhibits the reaction [Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein] |
CTD |
PMID:12223454 |
|
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
|
|
G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
multiple interactions |
ISO |
PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene D4] |
CTD |
PMID:25432964 |
|
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
|
|
G |
Selp |
selectin P |
increases expression |
ISO |
Leukotriene D4 results in increased expression of SELP protein |
CTD |
PMID:9152370 |
|
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
|
|
G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
ISO |
Leukotriene D4 promotes the reaction [SRC protein binds to PDGFRB protein]; Leukotriene D4 results in increased phosphorylation of and results in increased activity of SRC protein; pobilukast inhibits the reaction [Leukotriene D4 results in increased activity of SRC protein] |
CTD |
PMID:12223454 |
|
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
Leukotriene D4 promotes the reaction [CSF2 protein results in increased expression of TGFB1 protein]; Leukotriene D4 promotes the reaction [ICAM1 protein results in increased expression of TGFB1 protein]; Leukotriene D4 promotes the reaction [IL5 protein results in increased expression of TGFB1 protein] |
CTD |
PMID:15947480 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions increases secretion |
ISO |
[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein; BAY u9773 inhibits the reaction [Leukotriene D4 results in increased secretion of TNF protein]; montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of TNF protein]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein]; zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of TNF protein] |
CTD |
PMID:18704935 PMID:19118273 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
leupeptin inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:21818627 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Aqp8 |
aquaporin 8 |
multiple interactions |
EXP |
leupeptin inhibits the reaction [Ethinyl Estradiol results in decreased expression of AQP8 protein] |
CTD |
PMID:17110522 |
|
NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
leupeptin inhibits the reaction [Tretinoin results in increased cleavage of BAX protein] |
CTD |
PMID:16242776 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Casp6 |
caspase 6 |
multiple interactions |
ISO |
leupeptin inhibits the reaction [Estradiol results in increased degradation of and results in decreased activity of CASP6 protein] |
CTD |
PMID:15086513 |
|
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
|
|
G |
Cdc25c |
cell division cycle 25C |
multiple interactions increases expression |
ISO |
leupeptin inhibits the reaction [xanthatin results in decreased stability of CDC25C protein] leupeptin results in increased expression of CDC25C protein |
CTD |
PMID:29074359 |
|
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
|
|
G |
Cdh1 |
cadherin 1 |
multiple interactions |
EXP |
leupeptin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CDH1 protein] |
CTD |
PMID:19464575 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
|
|
G |
Cip2a |
cellular inhibitor of PP2A |
multiple interactions |
ISO |
leupeptin inhibits the reaction [temsirolimus results in decreased expression of CIP2A protein] |
CTD |
PMID:24493623 |
|
NCBI chr11:51,792,143...51,823,016
Ensembl chr11:51,795,024...51,822,938
|
|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
EXP |
leupeptin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CTNNB1 protein] |
CTD |
PMID:19464575 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
|
|
G |
Ctsb |
cathepsin B |
multiple interactions |
ISO |
leupeptin inhibits the reaction [CTSB protein results in increased degradation of NEFL protein] |
CTD |
PMID:11071371 |
|
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO |
leupeptin inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] |
CTD |
PMID:9143349 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Ddx3x |
DEAD-box helicase 3, X-linked |
multiple interactions |
ISO |
leupeptin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein] |
CTD |
PMID:30821613 |
|
NCBI chr X:9,479,532...9,493,169
Ensembl chr X:9,479,532...9,493,168
|
|
G |
Egf |
epidermal growth factor |
decreases degradation |
ISO |
leupeptin results in decreased degradation of EGF protein |
CTD |
PMID:23125191 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
|
|
G |
Eif4a1 |
eukaryotic translation initiation factor 4A1 |
multiple interactions |
ISO |
leupeptin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein] |
CTD |
PMID:30821613 |
|
NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858
|
|
G |
Eif4h |
eukaryotic translation initiation factor 4H |
multiple interactions |
ISO |
leupeptin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein] |
CTD |
PMID:30821613 |
|
NCBI chr12:22,083,155...22,099,876
Ensembl chr12:22,082,835...22,099,876
|
|
G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
ISO |
leupeptin inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA] |
CTD |
PMID:17559834 |
|
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
Fomepizole inhibits the reaction [leupeptin promotes the reaction [Acetaminophen results in increased activity of GPT protein]]; leupeptin promotes the reaction [Acetaminophen results in increased activity of GPT protein] |
CTD |
PMID:33458793 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
leupeptin inhibits the reaction [Particulate Matter results in increased secretion of IL1A protein] |
CTD |
PMID:21818627 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
leupeptin inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein] |
CTD |
PMID:21818627 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Klk8 |
kallikrein related-peptidase 8 |
decreases activity |
ISO |
leupeptin results in decreased activity of KLK8 protein |
CTD |
PMID:16800733 |
|
NCBI chr 1:94,251,803...94,258,646
Ensembl chr 1:94,251,803...94,258,646
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
leupeptin promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:33458793 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mt1 |
metallothionein 1 |
multiple interactions |
ISO |
leupeptin inhibits the reaction [MT1A protein results in decreased expression of XAF1 protein]; leupeptin inhibits the reaction [XAF1 protein results in decreased expression of MT1A protein] |
CTD |
PMID:28507149 |
|
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
|
|
G |
Mt2A |
metallothionein 2A |
multiple interactions |
ISO |
leupeptin inhibits the reaction [MT2A protein results in decreased expression of XAF1 protein]; leupeptin inhibits the reaction [XAF1 protein results in decreased expression of MT2A protein] |
CTD |
PMID:28507149 |
|
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
|
|
G |
Nefl |
neurofilament light chain |
multiple interactions |
ISO |
leupeptin inhibits the reaction [CTSB protein results in increased degradation of NEFL protein] |
CTD |
PMID:11071371 |
|
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
|
|
G |
Plin1 |
perilipin 1 |
multiple interactions decreases degradation |
ISO |
leupeptin inhibits the reaction [Nelfinavir results in increased degradation of PLIN1 protein] leupeptin results in decreased degradation of PLIN1 protein |
CTD |
PMID:17488708 |
|
NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828
|
|
G |
Tgfbr1 |
transforming growth factor, beta receptor 1 |
increases expression |
EXP |
leupeptin results in increased expression of TGFBR1 protein |
CTD |
PMID:27826032 |
|
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
|
|
G |
Xaf1 |
XIAP associated factor 1 |
multiple interactions |
ISO |
leupeptin inhibits the reaction [MT1A protein results in decreased expression of XAF1 protein]; leupeptin inhibits the reaction [MT2A protein results in decreased expression of XAF1 protein]; leupeptin inhibits the reaction [XAF1 protein results in decreased expression of MT1A protein]; leupeptin inhibits the reaction [XAF1 protein results in decreased expression of MT2A protein] |
CTD |
PMID:28507149 |
|
NCBI chr10:56,917,378...56,929,791
Ensembl chr10:56,917,121...56,929,770
|
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Leuprolide inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:17143537 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
Leuprolide results in increased expression of BAX protein |
CTD |
PMID:15965100 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
EXP |
Leuprolide results in increased expression of BCL2 mRNA |
CTD |
PMID:18829022 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Casp3 |
caspase 3 |
increases expression |
ISO |
Leuprolide results in increased expression of CASP3 protein |
CTD |
PMID:15965100 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
increases expression |
ISO |
Leuprolide results in increased expression of CASP9 protein |
CTD |
PMID:15965100 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cldn4 |
claudin 4 |
decreases expression |
ISO |
Leuprolide results in decreased expression of CLDN4 protein |
CTD |
PMID:21761342 |
|
NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
|
|
G |
Cldn8 |
claudin 8 |
decreases expression |
ISO |
Leuprolide results in decreased expression of CLDN8 protein |
CTD |
PMID:21761342 |
|
NCBI chr11:27,875,857...27,878,106
Ensembl chr11:27,875,692...27,878,513
|
|
G |
Cycs |
cytochrome c, somatic |
affects localization increases expression |
ISO EXP |
Leuprolide affects the localization of CYCS protein Leuprolide results in increased expression of CYCS mRNA |
CTD |
PMID:15965100 PMID:18829022 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
|
|
G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[Leuprolide co-treated with Testosterone] results in decreased expression of CYP19A1 mRNA |
CTD |
PMID:16032706 |
|
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
|
|
G |
Fshr |
follicle stimulating hormone receptor |
multiple interactions |
ISO |
[Leuprolide co-treated with Testosterone] results in decreased expression of FSHR mRNA |
CTD |
PMID:16032706 |
|
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
|
|
G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions |
ISO |
Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]; Leuprolide inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:17143537 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
|
|
G |
Igf1r |
insulin-like growth factor 1 receptor |
multiple interactions |
ISO |
Leuprolide results in decreased expression of and results in decreased phosphorylation of IGF1R protein |
CTD |
PMID:17143537 |
|
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
|
|
G |
Il6 |
interleukin 6 |
multiple interactions decreases expression |
EXP |
Leuprolide inhibits the reaction [resveratrol results in decreased expression of IL6 protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of IL6 protein] |
CTD |
PMID:25462211 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Itga5 |
integrin subunit alpha 5 |
multiple interactions |
ISO |
Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]] |
CTD |
PMID:17143537 |
|
NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
|
|
G |
Itgb3 |
integrin subunit beta 3 |
multiple interactions |
ISO |
Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]] |
CTD |
PMID:17143537 |
|
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
|
|
G |
Lhb |
luteinizing hormone subunit beta |
decreases expression |
ISO |
Leuprolide results in decreased expression of LHB protein |
CTD |
PMID:10221860 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
|
|
G |
Lhcgr |
luteinizing hormone/choriogonadotropin receptor |
multiple interactions decreases expression |
ISO |
[Leuprolide co-treated with Testosterone] results in decreased expression of LHCGR mRNA Leuprolide results in decreased expression of LHCGR mRNA |
CTD |
PMID:16032706 |
|
NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions decreases expression |
EXP |
Leuprolide inhibits the reaction [Resveratrol results in decreased expression of MMP2 protein]; Resveratrol inhibits the reaction [Leuprolide results in decreased expression of MMP2 protein] |
CTD |
PMID:25462211 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression multiple interactions |
EXP |
Leuprolide results in decreased expression of MMP9 protein Leuprolide inhibits the reaction [Resveratrol results in decreased expression of MMP9 protein]; Resveratrol inhibits the reaction [Leuprolide results in decreased expression of MMP9 protein] |
CTD |
PMID:25462211 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Leuprolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions decreases expression |
EXP |
Leuprolide inhibits the reaction [resveratrol results in decreased expression of TNF protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of TNF protein] |
CTD |
PMID:25462211 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Vegfa |
vascular endothelial growth factor A |
decreases expression multiple interactions |
EXP |
Leuprolide results in decreased expression of VEGFA protein Leuprolide inhibits the reaction [resveratrol results in decreased expression of VEGFA protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of VEGFA protein] |
CTD |
PMID:25462211 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
|
G |
Ace |
angiotensin I converting enzyme |
decreases activity |
ISO |
Lisinopril analog results in decreased activity of ACE protein |
CTD |
PMID:22200082 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
|
|
G |
Ace2 |
angiotensin converting enzyme 2 |
increases expression multiple interactions increases activity |
EXP ISO |
Lisinopril results in increased expression of ACE2 mRNA ACE2 protein affects the reaction [[[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7)] Lisinopril results in increased activity of ACE2 protein |
CTD |
PMID:15897343 PMID:16221218 PMID:27649628 |
|
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
|
|
G |
Ache |
acetylcholinesterase |
multiple interactions |
ISO EXP |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Lisinopril inhibits the reaction [Streptozocin results in increased activity of ACHE protein]]; Lisinopril inhibits the reaction [Streptozocin results in increased activity of ACHE protein] Lisinopril inhibits the reaction [Sodium Fluoride results in decreased activity of ACHE protein] |
CTD |
PMID:23060470 PMID:31710167 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
|
|
G |
Agt |
angiotensinogen |
decreases expression multiple interactions affects metabolic processing decreases secretion increases secretion affects response to substance increases expression |
ISO EXP |
Lisinopril results in decreased expression of AGT protein [[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [[Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril affects the metabolism of AGT protein] which results in increased abundance of angiotensin I (1-7); [Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein; [Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein; ACE2 protein affects the reaction [[[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7)]; Thiorphan inhibits the reaction [[Lisinopril affects the metabolism of AGT protein] which results in increased abundance of angiotensin I (1-7)] [[Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [[Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [[Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein] which results in decreased abundance of angiotensin I (1-7); [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein; [Lisinopril co-treated with Thiorphan co-treated with N-benzyloxycarbonylprolylprolinal] affects the metabolism of AGT protein; [Lisinopril co-treated with Thiorphan] affects the metabolism of AGT protein [Lisinopril co-treated with Losartan] results in increased expression of AGT mRNA Lisinopril results in decreased secretion of AGT protein Lisinopril results in increased secretion of AGT protein alternative form AGT gene alternative form affects the susceptibility to Lisinopril Lisinopril results in increased expression of AGT mRNA |
CTD |
PMID:8393685 PMID:8915971 PMID:15897343 PMID:16221218 PMID:16685205 PMID:27649628 More...
|
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
Lisinopril results in decreased expression of BCL2 |
CTD |
PMID:10075388 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Cd2ap |
CD2-associated protein |
multiple interactions |
EXP |
Lisinopril inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein] |
CTD |
PMID:16636307 |
|
NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199
|
|
G |
Edn1 |
endothelin 1 |
decreases secretion |
ISO |
Lisinopril results in decreased secretion of EDN1 protein |
CTD |
PMID:19079593 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
|
|
G |
Gh1 |
growth hormone 1 |
multiple interactions |
EXP |
[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]; [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]; [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA] |
CTD |
PMID:20051877 |
|
NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
|
|
G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 mRNA]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein] |
CTD |
PMID:19225054 |
|
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
|
|
G |
Hpse |
heparanase |
multiple interactions |
EXP |
[Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HPSE protein] |
CTD |
PMID:19429930 |
|
NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010
|
|
G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression |
ISO |
Lisinopril results in increased expression of IGFBP1 protein |
CTD |
PMID:9663927 |
|
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
EXP |
[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of MMP2 protein] |
CTD |
PMID:20051877 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Lisinopril inhibits the reaction [Streptozocin results in increased activity of MPO protein]]; Lisinopril inhibits the reaction [Streptozocin results in increased activity of MPO protein] |
CTD |
PMID:23060470 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA] |
CTD |
PMID:20051877 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nphs2 |
NPHS2 stomatin family member, podocin |
multiple interactions |
EXP |
Lisinopril affects the reaction [Doxorubicin results in increased expression of NPHS2 mRNA]; Lisinopril affects the reaction [Doxorubicin results in increased expression of NPHS2 protein] |
CTD |
PMID:16636307 |
|
NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
|
|
G |
Nppa |
natriuretic peptide A |
decreases expression |
ISO |
Lisinopril results in decreased expression of NPPA protein |
CTD |
PMID:8393685 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
|
|
G |
Ren |
renin |
increases expression multiple interactions |
ISO EXP |
Lisinopril results in increased expression of REN protein [Lisinopril co-treated with Losartan] results in increased expression of REN mRNA Lisinopril results in increased expression of REN mRNA |
CTD |
PMID:2550029 PMID:8915971 PMID:16221218 |
|
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
|
|
G |
RT1-M3-1 |
RT1 class Ib, locus M3, gene 1 |
affects expression |
ISO |
Lisinopril affects the expression of HLA-G mRNA |
CTD |
PMID:25811541 |
|
NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
|
|
G |
Spmip11 |
sperm microtubule inner protein 11 |
multiple interactions |
EXP |
Lisinopril inhibits the reaction [Doxorubicin results in decreased phosphorylation of NPHS1 protein]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of NPHS1 protein] |
CTD |
PMID:16636307 PMID:19293598 |
|
NCBI chr 7:129,720,950...129,742,485
Ensembl chr 7:129,720,950...129,742,485
|
|
G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
EXP |
[Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]; Lisinopril inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein] |
CTD |
PMID:20051877 |
|
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
EXP |
Lisinopril inhibits the reaction [Doxorubicin results in decreased expression of VEGFA protein] |
CTD |
PMID:19293598 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein] |
CTD |
PMID:34726822 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
maculosin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein] |
CTD |
PMID:34726822 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 mRNA]; maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 protein] |
CTD |
PMID:34726822 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cat |
catalase |
multiple interactions |
ISO |
maculosin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein] |
CTD |
PMID:34726822 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
maculosin inhibits the reaction [Diethylnitrosamine results in decreased activity of GSR protein] |
CTD |
PMID:34726822 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
multiple interactions |
ISO |
maculosin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein modified form] |
CTD |
PMID:34726822 |
|
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
|
|
G |
Pten |
phosphatase and tensin homolog |
multiple interactions |
ISO |
maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein] |
CTD |
PMID:34726822 |
|
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 mRNA]; maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein] |
CTD |
PMID:34726822 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
|
G |
F3 |
coagulation factor III, tissue factor |
increases expression |
ISO |
mifamurtide results in increased expression of F3 protein |
CTD |
PMID:25569083 |
|
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
|
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
morphiceptin analog affects the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; morphiceptin analog inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] |
CTD |
PMID:25149976 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Oprm1 |
opioid receptor, mu 1 |
multiple interactions |
EXP |
morphiceptin binds to and results in increased activity of OPRM1 protein |
CTD |
PMID:8383026 |
|
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
|
|
|
G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases abundance |
ISO |
BV6 decreases abundance of BIRC2 protein in colorectal cancer cells |
RGD |
PMID:31289894 |
RGD:152999013 |
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
|
|
G |
Birc3 |
baculoviral IAP repeat-containing 3 |
decreases abundance |
ISO |
BV6 decreases abundance of BIRC3 protein in colorectal cancer cells |
RGD |
PMID:31289894 |
RGD:152999013 |
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
|
|
|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
EXP ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [isoborneol results in decreased expression of ABCB1A protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [CERS6 protein affects the expression of ABCB1 protein] |
CTD |
PMID:26593909 PMID:34915026 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
|
|
G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [indolo(3,2-b)carbazole results in increased expression of ABCG2 mRNA] |
CTD |
PMID:17077187 |
|
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
|
|
G |
Acaa2 |
acetyl-CoA acyltransferase 2 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACAA2 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACAA2 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
|
|
G |
Ace |
angiotensin I converting enzyme |
multiple interactions |
ISO |
[Butyrates co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the localization of ACE protein mutant form; [Butyrates co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased activity of ACE protein mutant form |
CTD |
PMID:20454656 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
|
|
G |
Ace2 |
angiotensin converting enzyme 2 |
multiple interactions decreases expression |
ISO |
ATF6 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACE2 protein]; ERN1 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACE2 protein] |
CTD |
PMID:27638906 |
|
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
|
|
G |
Ache |
acetylcholinesterase |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lithium Chloride results in decreased stability of ACHE protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lithium Chloride results in increased degradation of ACHE protein] |
CTD |
PMID:22944069 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACTA2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
|
|
G |
Actb |
actin, beta |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACTB mRNA |
CTD |
PMID:15857753 |
|
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
|
|
G |
Actc1 |
actin, alpha, cardiac muscle 1 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACTC1 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACTC1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523
|
|
G |
Adam17 |
ADAM metallopeptidase domain 17 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ADAM17 protein 4-methylumbelliferone 8-carbaldehyde inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ADAM17 protein]; 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ADAM17 protein] |
CTD |
PMID:27638906 |
|
NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
|
|
G |
Adss1 |
adenylosuccinate synthase 1 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ADSS1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 6:131,679,795...131,702,012
Ensembl chr 6:131,679,701...131,701,998
|
|
G |
Agrp |
agouti related neuropeptide |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AGRP mRNA |
CTD |
PMID:20061341 |
|
NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
|
|
G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [AGT protein results in increased degradation of SYP protein] |
CTD |
PMID:18487452 PMID:26612707 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions increases expression increases localization affects localization decreases expression |
ISO EXP |
AHR protein affects the reaction [[TNF protein co-treated with alpinetin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [beta-hexachlorocyclohexane affects the expression of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-formylindolo(3,2-b)carbazole results in decreased expression of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [AHR protein results in decreased expression of VIM protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide results in decreased expression of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [AHR protein results in increased expression of ESR1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in decreased expression of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [herbimycin results in decreased expression of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [monorden results in decreased expression of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tanespimycin results in decreased expression of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of and affects the localization of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of and results in decreased expression of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [AHR protein binds to VIM protein] MG132 pretreatment increases expression of protein in liver of intestinal ischemia/reperfusion rats benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased localization of AHR protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the localization of AHR protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of and affects the localization of AHR protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of AHR protein |
CTD RGD |
PMID:10497241 PMID:10722677 PMID:10922479 PMID:12002481 PMID:12237327 PMID:12606767 PMID:15385644 PMID:15899923 PMID:16891617 PMID:17445780 PMID:20057149 PMID:27752740 PMID:31676321 PMID:33207735 PMID:34801851 PMID:37217010 PMID:22079846 More...
|
RGD:401794136 |
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKR1B1 mRNA |
CTD |
PMID:21215737 |
|
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
|
|
G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKR1B10 mRNA |
CTD |
PMID:21215737 |
|
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
|
|
G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKR1C1 mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin]] |
CTD |
PMID:21215737 PMID:23165153 |
|
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
|
|
G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
multiple interactions increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [tolfenamic acid inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Cisplatin]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKR1C3 mRNA |
CTD |
PMID:21215737 PMID:23165153 |
|
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [cadmium acetate results in decreased expression of AKT1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in decreased phosphorylation of AKT1 protein] AKT1 protein modified form inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with dihydromyricetin] results in increased ubiquitination of BIRC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [sodium arsenite affects the expression of AKT1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tubocapsenolide A results in increased degradation of AKT1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of AKT1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKT1 protein |
CTD |
PMID:18442981 PMID:24085292 PMID:24449419 PMID:24933620 PMID:32061799 PMID:33256086 PMID:36807944 More...
|
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Anln |
anillin, actin binding protein |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ANLN mRNA |
CTD |
PMID:25566086 PMID:31806706 |
|
NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538
|
|
G |
Anxa2 |
annexin A2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ANXA2 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
|
|
G |
Aoc3 |
amine oxidase, copper containing 3 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of AOC3 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr10:86,272,757...86,280,702
|
|
G |
Aph1a |
aph-1 homolog A, gamma secretase subunit |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of APH1A mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of APH1A mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 2:183,437,676...183,443,113
Ensembl chr 2:183,438,434...183,441,955
|
|
G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [APP protein modified form results in decreased expression of and results in decreased activity of TERT protein] |
CTD |
PMID:21520056 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G |
Appl1 |
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resiquimod results in increased degradation of APPL1 protein] |
CTD |
PMID:25780039 |
|
NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
|
|
G |
Aqp2 |
aquaporin 2 |
decreases degradation |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of AQP2 protein |
CTD |
PMID:21734099 |
|
NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
|
|
G |
Aqp3 |
aquaporin 3 (Gill blood group) |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP3 protein results in increased stability of EPAS1 protein]] |
CTD |
PMID:23545307 |
|
NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
|
|
G |
Aqp5 |
aquaporin 5 |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP5 protein results in increased stability of EPAS1 protein]] |
CTD |
PMID:23545307 |
|
NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
|
|
G |
Ar |
androgen receptor |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [decursin results in increased degradation of AR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [isobavachin results in decreased expression of and results in increased degradation of AR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulforaphane results in decreased expression of AR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Testosterone results in increased expression of AR mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [trichostatin A results in decreased expression of AR protein] |
CTD |
PMID:12376534 PMID:17723170 PMID:19805354 PMID:24740322 PMID:37019376 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
|
|
G |
Arg1 |
arginase 1 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ARG1 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ARG1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
|
|
G |
Arih1 |
ariadne RBR E3 ubiquitin protein ligase 1 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ARIH1 protein 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ARIH1 protein] |
CTD |
PMID:25624349 |
|
NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245
|
|
G |
Arl6ip5 |
ARF like GTPase 6 interacting protein 5 |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]] |
CTD |
PMID:21600884 |
|
NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608
|
|
G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
increases expression multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ARNT mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ARNT protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [SP1 protein binds to ARNT promoter]; bisindolylmaleimide I inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ARNT mRNA] |
CTD |
PMID:14529614 PMID:15899923 PMID:16880289 |
|
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
|
|
G |
Art3 |
ADP-ribosyltransferase 3 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ART3 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ART3 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr14:15,637,230...15,719,442
Ensembl chr14:15,637,237...15,665,407
|
|
G |
Asb2 |
ankyrin repeat and SOCS box-containing 2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ASB2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 6:122,474,754...122,511,014
Ensembl chr 6:122,474,756...122,510,854
|
|
G |
Atf3 |
activating transcription factor 3 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ATF3 protein Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ATF3 protein] |
CTD |
PMID:23593480 |
|
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
|
|
G |
Atf4 |
activating transcription factor 4 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ATF4 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ATF4 protein Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ATF4 protein] |
CTD |
PMID:14604972 PMID:17912641 PMID:23593480 PMID:31806706 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
|
|
G |
Atf6 |
activating transcription factor 6 |
multiple interactions increases expression |
ISO |
4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ATF6 protein]; ATF6 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACE2 protein]; ATF6 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of CTSD protein] |
CTD |
PMID:27638906 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
|
|
G |
Atg12 |
autophagy related 12 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of ATG12 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
|
|
G |
Atg13 |
autophagy related 13 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [ATG13 protein results in decreased expression of SQSTM1 protein] |
CTD |
PMID:27629431 |
|
NCBI chr 3:77,647,069...77,681,028
Ensembl chr 3:77,645,790...77,681,043
|
|
G |
Atg7 |
autophagy related 7 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [ATG7 protein results in decreased expression of SQSTM1 protein] |
CTD |
PMID:27629431 |
|
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
|
|
G |
Atp13a2 |
ATPase cation transporting 13A2 |
decreases response to substance |
ISO |
ATP13A2 protein results in decreased susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde analog |
CTD |
PMID:22847264 |
|
NCBI chr 5:153,292,722...153,312,143
Ensembl chr 5:153,292,751...153,312,139
|
|
G |
Atp1a1 |
ATPase Na+/K+ transporting subunit alpha 1 |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium Chloride results in decreased expression of ATP1A1 protein] |
CTD |
PMID:10506578 |
|
NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
|
|
G |
Atp5f1b |
ATP synthase F1 subunit beta |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [troglitazone results in decreased expression of ATP5F1B mRNA] |
CTD |
PMID:20860658 |
|
NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
|
|
G |
Atp7b |
ATPase copper transporting beta |
decreases degradation |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of ATP7B protein |
CTD |
PMID:21189263 |
|
NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
|
|
G |
Aurka |
aurora kinase A |
multiple interactions |
ISO |
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased expression of and results in increased phosphorylation of AURKA protein; MLN8054 inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased phosphorylation of AURKA protein] |
CTD |
PMID:24976383 |
|
NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
|
|
G |
Aurkb |
aurora kinase B |
multiple interactions |
ISO |
4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased phosphorylation of AURKB protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Nocodazole] results in increased phosphorylation of AURKB protein |
CTD |
PMID:24976383 |
|
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
|
|
G |
Bach1 |
BTB domain and CNC homolog 1 |
multiple interactions increases expression increases ubiquitination |
ISO |
2-tert-butylhydroquinone promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] affects the localization of BACH1 protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of BACH1 protein; [Hemin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of BACH1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tetrachlorobenzoquinone results in increased degradation of BACH1 protein]; hydroquinone promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 protein]; quinone promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BACH1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BACH1 protein |
CTD |
PMID:27393035 PMID:28645578 PMID:33434570 |
|
NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447
|
|
G |
Bag3 |
BAG cochaperone 3 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Staurosporine results in increased degradation of BAG3 protein] |
CTD |
PMID:19352495 |
|
NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
|
|
G |
Bak1 |
BCL2-antagonist/killer 1 |
increases ubiquitination |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BAK1 protein |
CTD |
PMID:36346691 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of BAX protein MitoTEMPO inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BAX protein] |
CTD |
PMID:15782132 PMID:19540902 PMID:34418242 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bbc3 |
Bcl-2 binding component 3 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein] |
CTD |
PMID:20530418 |
|
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
|
|
G |
Bcas2 |
BCAS2, pre-mRNA processing factor |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of BCAS2 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [evodiamine results in increased cleavage of BCL2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [trimethyltin chloride results in decreased expression of BCL2 protein] benzyloxycarbonyl-valyl-alanyl-aspartic acid promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of BCL2 protein]; MitoTEMPO inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of BCL2 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of BCL2; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of BCL2 protein |
CTD |
PMID:19540902 PMID:20005289 PMID:20100472 PMID:20449726 PMID:23423712 PMID:34418242 More...
|
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of BCL2L1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Topotecan results in increased degradation of BCL2L1 protein] |
CTD |
PMID:16960866 PMID:19540902 PMID:19812371 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
|
|
G |
Bcl2l11 |
Bcl2-like 11 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arsenic Trioxide results in increased degradation of BCL2L11 protein] |
CTD |
PMID:36509116 |
|
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
|
|
G |
Birc2 |
baculoviral IAP repeat-containing 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [BIRC2 protein results in increased degradation of SOD1 protein mutant form] |
CTD |
PMID:27773815 |
|
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
|
|
G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [BIRC3 protein results in increased degradation of SOD1 protein mutant form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BIRC3 mRNA] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BIRC3 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BIRC3 protein |
CTD |
PMID:14527959 PMID:24085292 PMID:27773815 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
|
|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
increases expression multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BIRC5 protein [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with dihydromyricetin] results in increased ubiquitination of BIRC5 protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with MK 2206] results in increased ubiquitination of BIRC5 protein; AKT1 protein modified form inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with dihydromyricetin] results in increased ubiquitination of BIRC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [(+)-JQ1 compound results in decreased expression of BIRC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of BIRC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Capsaicin results in decreased expression of BIRC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [dihydromyricetin results in decreased expression of BIRC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Quercetin results in decreased expression of BIRC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased susceptibility to [Oxaliplatin results in decreased expression of BIRC5 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of BIRC5 mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Topotecan results in increased degradation of BIRC5 protein] |
CTD |
PMID:16328441 PMID:17510429 PMID:17548900 PMID:19812371 PMID:19939880 PMID:20708607 PMID:23872705 PMID:25566086 PMID:36807944 More...
|
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
|
|
G |
Blvrb |
biliverdin reductase B |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BLVRB mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375
|
|
G |
Bmi1 |
BMI1 proto-oncogene, polycomb ring finger |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BMI1 protein |
CTD |
PMID:33157086 |
|
NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690
|
|
G |
Bnip3 |
BCL2 interacting protein 3 |
multiple interactions increases expression |
ISO |
[arsenic trioxide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of BNIP3 mRNA; arsenic trioxide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BNIP3 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Valproic Acid results in increased expression of BNIP3 mRNA] |
CTD |
PMID:25446377 |
|
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
|
|
G |
Bok |
BCL2 family apoptosis regulator BOK |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of BOK mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
|
|
G |
Brd4 |
bromodomain containing 4 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [BRD4 mutant form affects the localization of RELA protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [STA 9090 inhibits the reaction [PKD1 gene mutant form results in increased expression of BRD4 protein]] |
CTD |
PMID:23686307 PMID:25877301 PMID:26051217 |
|
NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
|
|
G |
C1qb |
complement C1q B chain |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of C1QB mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
|
|
G |
Cacna1h |
calcium voltage-gated channel subunit alpha1 H |
decreases expression decreases degradation |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CACNA1H mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of CACNA1H protein |
CTD |
PMID:25566086 PMID:30552955 |
|
NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
|
|
G |
Canx |
calnexin |
affects localization |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the localization of CANX protein |
CTD |
PMID:17912641 |
|
NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
|
|
G |
Capn1 |
calpain 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Acrylamide results in increased expression of CAPN1 protein] |
CTD |
PMID:37353096 |
|
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
|
|
G |
Car14 |
carbonic anhydrase 14 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CAR14 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CAR14 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 2:183,442,263...183,449,231
Ensembl chr 2:183,441,667...183,449,693
|
|
G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP1 protein]; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP1 protein]] |
CTD |
PMID:15914627 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases cleavage increases expression increases activity |
ISO EXP |
4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of CASP3 protein]; [Arsenic Trioxide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased cleavage of CASP3 protein; [XBP1 mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [evodiamine results in increased activity of and results in increased cleavage of CASP3 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of and results in increased activity of CASP3 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CASP3 protein modified form benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of CASP3 protein Acetylcysteine inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of CASP3 protein] |
CTD |
PMID:15498850 PMID:15725397 PMID:16880202 PMID:18463101 PMID:18790767 PMID:20005289 PMID:20100472 PMID:20449726 PMID:20649845 PMID:23684743 PMID:25449439 PMID:25568320 PMID:27638906 PMID:29944914 PMID:34418242 More...
|
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp6 |
caspase 6 |
multiple interactions decreases activity |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP6 protein]; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP6 protein]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased activity of CASP6 protein |
CTD |
PMID:15914627 |
|
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
|
|
G |
Casp7 |
caspase 7 |
increases activity |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of CASP7 protein |
CTD |
PMID:19139269 |
|
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
|
|
G |
Casp8 |
caspase 8 |
multiple interactions increases activity |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of and results in increased activity of CASP8 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of CASP8 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP8 protein]; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP8 protein]] |
CTD |
PMID:15498850 PMID:15914627 PMID:20100472 PMID:20449726 PMID:20671745 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
G |
Casp9 |
caspase 9 |
multiple interactions increases activity |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of and results in increased activity of CASP9 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of CASP9 protein |
CTD |
PMID:15498850 PMID:16880202 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cast |
calpastatin |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Acrylamide results in increased cleavage of CAST protein] |
CTD |
PMID:37353096 |
|
NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659
|
|
G |
Cat |
catalase |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CAT mRNA CAT protein inhibits the reaction [[SOD2 protein co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of HDAC2 protein] |
CTD |
PMID:20061341 PMID:24973648 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Cav1 |
caveolin 1 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CAV1 protein [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of CAV1 mRNA |
CTD |
PMID:19706615 PMID:25566086 |
|
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
|
|
G |
Cavin1 |
caveolae associated protein 1 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CAVIN1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr10:85,884,100...85,896,136
Ensembl chr10:85,889,036...85,896,120
|
|
G |
Cavin2 |
caveolae associated protein 2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CAVIN2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 9:50,302,079...50,314,096
Ensembl chr 9:50,301,206...50,314,147
|
|
G |
Cbr3 |
carbonyl reductase 3 |
increases expression |
ISO |
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 protein] which results in increased expression of CBR3 mRNA |
CTD |
PMID:20806931 |
|
NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased secretion of CCL2 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA] |
CTD |
PMID:10541287 PMID:11230753 PMID:11698246 PMID:15139008 PMID:19945525 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CCNA2 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
|
|
G |
Ccnb1 |
cyclin B1 |
multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [arsenite results in increased ubiquitination of CCNB1 protein] [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of CCNB1 mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CCNB1 mRNA |
CTD |
PMID:17373649 PMID:20061341 PMID:25566086 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
|
|
G |
Ccnb2 |
cyclin B2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CCNB2 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
|
|
G |
Ccnd1 |
cyclin D1 |
multiple interactions increases expression increases phosphorylation |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of CCND1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of CCND1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [3,3'-diindolylmethane analog results in decreased expression of CCND1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [alopestatin metabolite results in decreased expression of CCND1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Carbamazepine results in decreased expression of CCND1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Carbamazepine results in decreased expression of CCND1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of CCND1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of CCND1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [kahweol results in decreased expression of CCND1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [lysocellin results in decreased expression of CCND1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [nickel chloride results in decreased expression of and results in increased degradation of CCND1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [nickel chloride results in decreased phosphorylation of CCND1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CCND1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of CCND1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dexamethasone results in increased degradation of CCND1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of CCND1 protein] |
CTD |
PMID:15247282 PMID:16051428 PMID:16525630 PMID:16707792 PMID:16965676 PMID:18792914 PMID:20394812 PMID:21472727 PMID:24231000 PMID:27424123 PMID:28548306 PMID:30703377 More...
|
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Ccnd3 |
cyclin D3 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CCND3 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
|
|
G |
Ccs |
copper chaperone for superoxide dismutase |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Copper Sulfate co-treated with 2,3,2-tetramine] results in increased degradation of CCS protein] |
CTD |
PMID:12832419 |
|
NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915
|
|
G |
Cd14 |
CD14 molecule |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CD14 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CD14 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
|
|
G |
Cd1d1 |
CD1d1 molecule |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CD1D1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
|
|
G |
Cd248 |
CD248 molecule |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CD248 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 1:202,373,676...202,376,240
Ensembl chr 1:202,373,676...202,376,240
|
|
G |
Cd36 |
CD36 molecule |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CD36 protein] |
CTD |
PMID:36534932 |
|
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
|
|
G |
Cdc20 |
cell division cycle 20 |
multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium Chloride results in increased degradation of CDC20 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CDC20 mRNA |
CTD |
PMID:20054826 PMID:20061341 PMID:25566086 |
|
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
|
|
G |
Cdc25b |
cell division cycle 25B |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CDC25B mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
|
|
G |
Cdc25c |
cell division cycle 25C |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CDC25C mRNA |
CTD |
PMID:20061341 |
|
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
|
|
G |
Cdca3 |
cell division cycle associated 3 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CDCA3 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799
|
|
G |
Cdh3 |
cadherin 3 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of CDH3 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
|
|
G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CDK1 mRNA [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of CDK1 mRNA |
CTD |
PMID:20061341 PMID:25566086 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
|
|
G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [troglitazone results in decreased expression of CDK2 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [bruceantinol results in decreased expression of CDK2 protein] |
CTD |
PMID:15610522 PMID:38608999 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
|
|
G |
Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [bruceantinol results in decreased expression of CDK4 protein] |
CTD |
PMID:38608999 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
|
|
G |
Cdk6 |
cyclin-dependent kinase 6 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [bruceantinol results in decreased expression of CDK6 protein] |
CTD |
PMID:38608999 |
|
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
decreases degradation |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of CDKN1B protein |
CTD |
PMID:17283133 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
|
|
G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CDKN2A mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
|
|
G |
Cdkn2c |
cyclin-dependent kinase inhibitor 2C |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CDKN2C mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
|
|
G |
Cdkn3 |
cyclin-dependent kinase inhibitor 3 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CDKN3 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
|
|
G |
Cebpa |
CCAAT/enhancer binding protein alpha |
increases ubiquitination multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of CEBPA protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [NSC606985 results in decreased expression of CEBPA protein] |
CTD |
PMID:19662097 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
|
|
G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of and results in increased localization of CEBPB protein; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of and results in increased localization of CEBPB protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of CEBPB protein] |
CTD |
PMID:11779194 PMID:15319326 |
|
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
|
|
G |
Cebpd |
CCAAT/enhancer binding protein delta |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of and results in increased localization of CEBPD protein; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of and results in increased localization of CEBPD protein] |
CTD |
PMID:11779194 |
|
NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
|
|
G |
Cebpe |
CCAAT/enhancer binding protein epsilon |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tretinoin results in increased expression of CEBPE protein] |
CTD |
PMID:20945414 |
|
NCBI chr15:28,169,711...28,171,471
Ensembl chr15:28,169,704...28,171,814
|
|
G |
Cenpa |
centromere protein A |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CENPA mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CENPA mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
|
|
G |
Cers6 |
ceramide synthase 6 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [CERS6 protein affects the expression of ABCB1 protein] |
CTD |
PMID:34915026 |
|
NCBI chr 3:53,630,637...53,879,692
Ensembl chr 3:53,630,959...53,876,848
|
|
G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
affects expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the expression of CFLAR protein alternative form benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [(+)-JQ1 compound results in decreased expression of CFLAR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [alvocidib results in decreased expression of CFLAR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Quercetin results in decreased expression of CFLAR protein alternative form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [shogaol results in decreased expression of CFLAR protein modified form] |
CTD |
PMID:16951203 PMID:17510429 PMID:18980244 PMID:25619640 PMID:26415225 |
|
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
|
|
G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] |
CTD |
PMID:18230692 |
|
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
|
|
G |
Chek1 |
checkpoint kinase 1 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CHEK1 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
|
|
G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CHRM2 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
|
|
G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
increases activity |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of CHUK protein |
CTD |
PMID:24085292 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
|
|
G |
Cidea |
cell death-inducing DFFA-like effector a |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CIDEA mRNA |
CTD |
PMID:25566086 |
|
NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
|
|
G |
Cited4 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CITED4 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 5:134,246,936...134,247,827
Ensembl chr 5:134,246,682...134,248,135
|
|
G |
Ckb |
creatine kinase B |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of CKB mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
|
|
G |
Ckmt2 |
creatine kinase, mitochondrial 2 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CKMT2 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CKMT2 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 2:23,079,918...23,110,518
Ensembl chr 2:23,079,918...23,110,430
|
|
G |
Cldn4 |
claudin 4 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CLDN4 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CLDN4 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
|
|
G |
Cldn5 |
claudin 5 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of and affects the localization of CLDN5 protein] |
CTD |
PMID:34391839 |
|
NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
|
|
G |
Clip4 |
CAP-GLY domain containing linker protein family, member 4 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CLIP4 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 6:23,616,280...23,697,625 NCBI chr 6:23,718,580...23,729,231 NCBI chr 6:23,597,729...23,601,000
Ensembl chr 6:23,616,281...23,677,874
|
|
G |
Cmya5 |
cardiomyopathy associated 5 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CMYA5 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 2:24,279,520...24,378,253
Ensembl chr 2:24,279,528...24,378,364
|
|
G |
Cnr1 |
cannabinoid receptor 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA] |
CTD |
PMID:21525939 |
|
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
|
|
G |
Cnr2 |
cannabinoid receptor 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA] |
CTD |
PMID:21525939 |
|
NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Asbestos, Amosite results in increased expression of COL1A1 mRNA] |
CTD |
PMID:11306436 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
|
|
G |
Commd1 |
copper metabolism domain containing 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of COMMD1 protein |
CTD |
PMID:23401744 |
|
NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501
|
|
G |
Corin |
corin, serine peptidase |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CORIN mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CORIN mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503
|
|
G |
Cox4i2 |
cytochrome c oxidase subunit 4i2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of COX4I2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 3:141,228,443...141,239,337
Ensembl chr 3:141,228,443...141,239,331
|
|
G |
Cpxm1 |
carboxypeptidase X (M14 family), member 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CPXM1 mRNA |
CTD |
PMID:20061341 PMID:25566086 |
|
NCBI chr 3:117,588,532...117,595,330
Ensembl chr 3:117,588,532...117,595,330
|
|
G |
Crct1 |
cysteine-rich C-terminal 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CRCT1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 2:178,633,789...178,635,274
Ensembl chr 2:178,634,092...178,634,394
|
|
G |
Crebbp |
CREB binding protein |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Valproic Acid results in decreased expression of CREBBP protein] |
CTD |
PMID:27381264 |
|
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
|
|
G |
Crip2 |
cysteine-rich protein 2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CRIP2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065
|
|
G |
Cryaa |
crystallin, alpha A |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CRYAA mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CRYAA protein |
CTD |
PMID:15914627 |
|
NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349
|
|
G |
Cryab |
crystallin, alpha B |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CRYAB mRNA |
CTD |
PMID:15914627 |
|
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
|
|
G |
Csnk2b |
casein kinase 2 beta |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diethylhexyl Phthalate results in increased degradation of CSNK2B protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNFAIP1 protein results in increased degradation of CSNK2B protein] |
CTD |
PMID:37302538 |
|
NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133
|
|
G |
Cst5 |
cystatin D |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CST5 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 3:137,573,194...137,577,754
Ensembl chr 3:137,573,194...137,577,754
|
|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions decreases degradation |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of CTNNB1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [arctigenin results in decreased expression of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Aspirin results in increased ubiquitination of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [GW 4064 results in decreased expression of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [quinocetone results in decreased expression of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [RASSF5 protein results in decreased expression of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Vitamin A results in decreased expression of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Nitroglycerin results in increased degradation of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of and affects the localization of CTNNB1 protein; thymoquinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of CTNNB1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the phosphorylation of and affects the localization of CTNNB1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of CTNNB1 protein; Phenobarbital inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CTNNB1 protein] |
CTD |
PMID:14555707 PMID:16878161 PMID:17030184 PMID:17219422 PMID:20510325 PMID:21472727 PMID:25217643 PMID:26990689 PMID:27693619 PMID:28343033 PMID:28548306 PMID:31115591 PMID:32112862 PMID:34900531 PMID:38216027 More...
|
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
|
|
G |
Ctsd |
cathepsin D |
increases cleavage multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of CTSD protein 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of CTSD protein]; ATF6 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of CTSD protein]; ERN1 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of CTSD protein] |
CTD |
PMID:27638906 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
|
|
G |
Cul2 |
cullin 2 |
multiple interactions |
ISO |
CUL2 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of MAF1 protein] |
CTD |
PMID:31645432 |
|
NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968
|
|
G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CX3CL1 mRNA] |
CTD |
PMID:11698246 |
|
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
|
|
G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CXCL1 protein] |
CTD |
PMID:11698246 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
|
|
G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CXCL12 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
|
|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CXCL1 protein] |
CTD |
PMID:11698246 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
|
|
G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TPD7 compound results in decreased expression of CXCR4 protein] |
CTD |
PMID:25753200 |
|
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
|
|
G |
Cycs |
cytochrome c, somatic |
affects localization |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the localization of CYCS protein |
CTD |
PMID:15725397 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression increases activity |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Harmine results in decreased stability of CYP1A1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [harmol results in decreased stability of CYP1A1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CYP1A1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CYP1A1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of CYP1A1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in increased expression of CYP1A1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Copper results in increased expression of CYP1A1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cycloheximide results in increased expression of CYP1A1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Lead results in increased expression of CYP1A1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Mercury results in increased expression of CYP1A1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:10722677 PMID:10777561 PMID:16093525 PMID:16891617 PMID:17606337 PMID:18835339 PMID:22001777 PMID:22037238 More...
|
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP |
MG132 pretreatment increases expression of protein in liver of intestinal ischemia/reperfusion rats |
RGD |
PMID:22079846 |
RGD:401794136 |
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases stability |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased stability of CYP1B1 protein |
CTD |
PMID:15486049 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G |
Cyp26a1 |
cytochrome P450, family 26, subfamily a, polypeptide 1 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CYP26A1 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
|
|
G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA] |
CTD |
PMID:24224465 |
|
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:24224465 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
|
|
G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dexamethasone results in increased expression of CYP3A23-3A1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dexamethasone results in increased expression of CYP3A23-3A1 protein] |
CTD |
PMID:17083955 |
|
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
|
|
G |
Ddc |
dopa decarboxylase |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of DDC mRNA |
CTD |
PMID:25566086 |
|
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
|
|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression increases activity |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DDIT3 mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DDIT3 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of DDIT3 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DDIT3 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DDIT3 protein |
CTD |
PMID:17912641 PMID:19135031 PMID:19139269 PMID:22959925 PMID:23684743 PMID:25566086 PMID:27638906 More...
|
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
|
|
G |
Dffa |
DNA fragmentation factor subunit alpha |
multiple interactions |
ISO |
DFFA protein inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of DFFB protein] |
CTD |
PMID:18178165 |
|
NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633
|
|
G |
Dffb |
DNA fragmentation factor subunit beta |
multiple interactions decreases degradation increases ubiquitination |
ISO |
DFFA protein inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of DFFB protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of DFFB protein |
CTD |
PMID:18178165 |
|
NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
|
|
G |
Diablo |
diablo, IAP-binding mitochondrial protein |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cannabidiol promotes the reaction [DIABLO protein binds to XIAP protein]] |
CTD |
PMID:31699976 |
|
NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
|
|
G |
Dio2 |
iodothyronine deiodinase 2 |
multiple interactions increases expression increases activity |
ISO EXP |
[Cycloheximide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] inhibits the reaction [2,2',4,4',5-brominated diphenyl ether metabolite results in decreased activity of DIO2 protein]; [Cycloheximide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased activity of DIO2 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [2,2',4,4',5-brominated diphenyl ether results in decreased activity of DIO2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide results in decreased activity of DIO2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [decabromobiphenyl ether results in increased degradation of DIO2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of and results in increased activity of DIO2 protein; Cycloheximide promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [2,2',4,4',5-brominated diphenyl ether results in decreased activity of DIO2 protein]]; Cycloheximide promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DIO2 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of DIO2 protein |
CTD |
PMID:11425850 PMID:17615150 PMID:26004626 PMID:37330034 |
|
NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
|
|
G |
Dnajb1 |
DnaJ heat shock protein family (Hsp40) member B1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DNAJB1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DNAJB1 protein |
CTD |
PMID:15525353 PMID:25566086 |
|
NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458
|
|
G |
Dnajc2 |
DnaJ heat shock protein family (Hsp40) member C2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DNAJC2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 4:13,270,239...13,297,438
Ensembl chr 4:13,270,191...13,297,431
|
|
G |
Dnajc7 |
DnaJ heat shock protein family (Hsp40) member C7 |
multiple interactions increases ubiquitination |
ISO |
1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of DNAJC7 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [DNAJC7 protein results in increased expression of NR1I3 protein]; NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of DNAJC7 protein]] |
CTD |
PMID:24789201 |
|
NCBI chr10:85,518,637...85,555,079
Ensembl chr10:85,518,621...85,555,575
|
|
G |
Dnmt1 |
DNA methyltransferase 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Benzo(a)pyrene results in increased degradation of DNMT1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of DNMT1 protein] |
CTD |
PMID:21150308 PMID:23395981 |
|
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
|
|
G |
Dnmt3a |
DNA methyltransferase 3 alpha |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of DNMT3A protein] |
CTD |
PMID:23395981 |
|
NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
|
|
G |
Dnmt3b |
DNA methyltransferase 3 beta |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of DNMT3B protein] |
CTD |
PMID:23395981 |
|
NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
|
|
G |
Dnmt3l |
DNA methyltransferase 3 like |
multiple interactions increases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DNMT3L mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr20:10,614,933...10,629,337
Ensembl chr20:10,614,934...10,629,516
|
|
G |
Dpp7 |
dipeptidylpeptidase 7 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[DPP7 protein results in increased cleavage of Dipeptides] which results in increased abundance of 4-nitroaniline] |
CTD |
PMID:16725115 |
|
NCBI chr 3:8,165,091...8,169,343
Ensembl chr 3:8,165,091...8,169,355
|
|
G |
Dusp1 |
dual specificity phosphatase 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SKP2 protein results in decreased expression of DUSP1 protein] |
CTD |
PMID:34697729 |
|
NCBI chr10:16,680,478...16,683,275
|
|
G |
Dync1h1 |
dynein cytoplasmic 1 heavy chain 1 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DYNC1H1 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DYNC1H1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
|
|
G |
Dync1i1 |
dynein cytoplasmic 1 intermediate chain 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DYNC1I1 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 4:33,852,597...34,166,159
Ensembl chr 4:33,852,927...34,166,149
|
|
G |
E2f1 |
E2F transcription factor 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dronabinol results in decreased expression of E2F1 protein] |
CTD |
PMID:17934890 |
|
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
|
|
G |
E2f2 |
E2F transcription factor 2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of E2F2 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
|
|
G |
Edn1 |
endothelin 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of EDN1 mRNA |
CTD |
PMID:18457675 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
|
|
G |
Egf |
epidermal growth factor |
multiple interactions increases expression |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [EGF protein affects the localization of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of EGF mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]; Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]] |
CTD |
PMID:22689575 PMID:22766066 PMID:31806706 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
|
|
G |
Egfl7 |
EGF-like-domain, multiple 7 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of EGFL7 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 3:9,404,622...9,416,879
Ensembl chr 3:9,407,520...9,416,879
|
|
G |
Egfr |
epidermal growth factor receptor |
multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [MUC1 affects the expression of EGFR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [platycodin D results in decreased expression of EGFR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of EGFR protein |
CTD |
PMID:17146438 PMID:20332299 PMID:22457794 PMID:28711525 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
|
|
G |
Egln1 |
egl-9 family hypoxia-inducible factor 1 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of EGLN1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777
|
|
G |
Egln3 |
egl-9 family hypoxia-inducible factor 3 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of EGLN3 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of EGLN3 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
|
|
G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of EIF2AK2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
|
|
G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions increases phosphorylation |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of EIF2AK3 mRNA]] 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:22959925 PMID:27638906 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
|
|
G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation multiple interactions increases expression |
EXP ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of EIF2S1 protein 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of EIF2S1 protein]; [XBP1 mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of EIF2S1 protein]; PTPN1 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of EIF2S1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of EIF2S1 protein modified form |
CTD |
PMID:21090173 PMID:22321511 PMID:23684743 PMID:25568320 PMID:27638906 PMID:28359145 More...
|
|
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
|
|
G |
Eif4e |
eukaryotic translation initiation factor 4E |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein] |
CTD |
PMID:15878868 |
|
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
|
|
G |
Elavl1 |
ELAV like RNA binding protein 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ELAVL1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ELAVL1 protein |
CTD |
PMID:23922739 |
|
NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
|
|
G |
Emcn |
endomucin |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of EMCN mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 2:225,891,100...225,970,932
Ensembl chr 2:225,891,100...225,970,929
|
|
G |
Eno3 |
enolase 3 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ENO3 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ENO3 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
|
|
G |
Ep300 |
E1A binding protein p300 |
multiple interactions |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased degradation of EP300 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SIRT6 protein results in decreased expression of EP300 protein] |
CTD |
PMID:15767673 PMID:17927689 PMID:27094368 |
|
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
|
|
G |
Epas1 |
endothelial PAS domain protein 1 |
multiple interactions increases ubiquitination increases expression increases hydroxylation increases stability |
EXP ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP3 protein results in increased stability of EPAS1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP5 protein results in increased stability of EPAS1 protein]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of EPAS1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of EPAS1 protein [Formaldehyde co-treated with pevonedistat co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the folding of EPAS1 protein; [Formaldehyde co-treated with VH298 co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the folding of EPAS1 protein; [VH298 co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the folding of EPAS1 protein; arsenite inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of EPAS1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [MALAT1 mRNA promotes the reaction [sodium arsenite results in increased expression of EPAS1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [sodium arsenite results in increased expression of EPAS1 protein]; MALAT1 mRNA promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased hydroxylation of EPAS1 protein]; MALAT1 mRNA promotes the reaction [sodium arsenite promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased hydroxylation of EPAS1 protein]]; sodium arsenite promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased hydroxylation of EPAS1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased stability of EPAS1 protein |
CTD |
PMID:22447124 PMID:23545307 PMID:26735578 PMID:35504338 |
|
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
|
|
G |
Ephb4 |
EPH receptor B4 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homoharringtonine results in decreased expression of EPHB4 protein] |
CTD |
PMID:31726078 |
|
NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314
|
|
G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of EPHX1 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
|
|
G |
Ephx2 |
epoxide hydrolase 2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of EPHX2 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
|
|
G |
Epo |
erythropoietin |
multiple interactions increases expression |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [methylmercuric chloride results in decreased expression of EPO protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Methylmercury Compounds results in decreased expression of EPO protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of EPO protein |
CTD |
PMID:31850806 PMID:32461003 |
|
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
|
|
G |
Eppk1 |
epiplakin 1 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of EPPK1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 7:107,816,919...107,842,946
Ensembl chr 7:107,817,693...107,831,159
|
|
G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ERBB2 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ERBB2 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Berberine results in decreased expression of ERBB2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [demethoxycurcumin results in increased degradation of ERBB2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Quercetin results in decreased expression of ERBB2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of ERBB2 protein] |
CTD |
PMID:18655187 PMID:20332299 PMID:31806706 PMID:33325633 PMID:34291863 |
|
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
|
|
G |
Erbb3 |
erb-b2 receptor tyrosine kinase 3 |
multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of ERBB3 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of ERBB3 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ERBB3 protein |
CTD |
PMID:20332299 |
|
NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
|
|
G |
Ercc6 |
ERCC excision repair 6, chromatin remodeling factor |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] |
CTD |
PMID:25440059 |
|
NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
|
|
G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
increases expression increases phosphorylation multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ERN1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of ERN1 protein ERN1 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACE2 protein]; ERN1 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of CTSD protein] |
CTD |
PMID:19139269 PMID:27638906 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
|
|
G |
Esr1 |
estrogen receptor 1 |
multiple interactions increases expression increases ubiquitination decreases expression |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-prenylnaringenin results in decreased expression of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [8-prenylnaringenin results in decreased expression of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [baohuoside I results in increased degradation of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Butyrophenones results in increased degradation of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Carbamazepine results in decreased expression of ESR1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Carbamazepine results in decreased expression of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [AHR protein results in increased expression of ESR1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Estradiol inhibits the reaction [ESR1 protein binds to GSK3B protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Estradiol results in decreased expression of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Fulvestrant results in decreased expression of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Okadaic Acid results in increased degradation of ESR1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Plant Extracts results in decreased expression of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Resveratrol results in increased degradation of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [xanthohumol results in decreased expression of ESR1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ESR1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of ESR1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ESR1 mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [fulvestrant results in increased degradation of ESR1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [PTK2B protein affects the ubiquitination of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Estradiol results in decreased expression of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gonadotropin-Releasing Hormone results in decreased expression of ESR1 protein] |
CTD |
PMID:12612060 PMID:14702340 PMID:14750165 PMID:15965230 PMID:16055746 PMID:16564422 PMID:16965676 PMID:20419096 PMID:21041310 PMID:26990689 PMID:29428397 PMID:31806706 PMID:32986415 PMID:34801851 PMID:35802278 More...
|
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
Esr2 |
estrogen receptor 2 |
multiple interactions increases expression |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Estradiol results in increased expression of ESR2 mRNA] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ESR2 protein |
CTD |
PMID:14702340 PMID:15207704 PMID:16564422 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
|
|
G |
Esrra |
estrogen related receptor, alpha |
multiple interactions increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HDAC6 protein results in increased expression of ESRRA protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ESRRA protein |
CTD |
PMID:34524571 |
|
NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
|
|
G |
Fahd1 |
fumarylacetoacetate hydrolase domain containing 1 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of FAHD1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr10:13,873,539...13,874,978
Ensembl chr10:13,873,527...13,875,012
|
|
G |
Fam13b |
family with sequence similarity 13, member B |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of FAM13B mRNA |
CTD |
PMID:25566086 |
|
NCBI chr18:26,040,285...26,107,112
Ensembl chr18:26,040,285...26,106,587
|
|
G |
Fam78a |
family with sequence similarity 78, member A |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of FAM78A mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 3:15,355,958...15,376,330
Ensembl chr 3:15,355,955...15,373,812
|
|
G |
Faslg |
Fas ligand |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [evodiamine results in increased expression of FASLG protein] |
CTD |
PMID:20005289 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
|
|
G |
Fbxl12 |
F-box and leucine-rich repeat protein 12 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of FBXL12 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 8:19,175,864...19,183,373
Ensembl chr 8:19,160,352...19,183,607
|
|
G |
Fbxo10 |
F-box protein 10 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of FBXO10 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 5:59,297,016...59,343,429
Ensembl chr 5:59,297,045...59,343,348
|
|
G |
Fbxo2 |
F-box protein 2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of FBXO2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 5:158,592,926...158,598,355
Ensembl chr 5:158,592,925...158,598,355
|
|
G |
Fbxo32 |
F-box protein 32 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [FBXO32 protein results in decreased expression of KCNN2 protein] |
CTD |
PMID:30635400 |
|
NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436
|
|
G |
Fbxo6 |
F-box protein 6 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of FBXO6 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 5:158,576,729...158,582,520
Ensembl chr 5:158,576,759...158,582,525
|
|
G |
Fbxw7 |
F-box and WD repeat domain containing 7 |
multiple interactions |
ISO |
FBXW7 protein promotes the reaction [NFKB1 gene mutant form inhibits the reaction [arsenite inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of MYC protein]]]] |
CTD |
PMID:24457827 |
|
NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941
|
|
G |
Fhl2 |
four and a half LIM domains 2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of FHL2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192
|
|
G |
Fis1 |
fission, mitochondrial 1 |
multiple interactions increases expression |
EXP ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of FIS1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[PARK protein co-treated with UBB protein] results in decreased expression of FIS1 protein] |
CTD |
PMID:20164189 |
|
NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
|
|
G |
Flnc |
filamin C |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of FLNC mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844
|
|
G |
Fn1 |
fibronectin 1 |
decreases secretion |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased secretion of FN1 protein |
CTD |
PMID:11594554 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hydrogen Peroxide results in increased expression of FOS protein] [Arachidonic Acid co-treated with Quercetin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of FOS protein |
CTD |
PMID:15136564 PMID:20551291 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]] |
CTD |
PMID:17148446 |
|
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
|
|
G |
Foxm1 |
forkhead box M1 |
multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [palbociclib results in decreased expression of FOXM1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of FOXM1 mRNA |
CTD |
PMID:22094256 PMID:31806706 |
|
NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684
|
|
G |
Foxo1 |
forkhead box O1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [dorsomorphin results in decreased expression of FOXO1 protein] |
CTD |
PMID:25065674 |
|
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
|
|
G |
Foxo3 |
forkhead box O3 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arsenic Trioxide results in increased expression of FOXO3 protein] |
CTD |
PMID:31421153 |
|
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
|
|
G |
Fsd2 |
fibronectin type III and SPRY domain containing 2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of FSD2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 1:135,484,002...135,522,517
Ensembl chr 1:135,489,266...135,522,472
|
|
G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [diallyl trisulfide results in increased degradation of and results in decreased expression of FTH1 protein] |
CTD |
PMID:16707465 |
|
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
|
|
G |
Ftl1 |
ferritin light chain 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [diallyl trisulfide results in increased degradation of and results in decreased expression of FTL protein] |
CTD |
PMID:16707465 |
|
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
|
|
G |
Fundc1 |
FUN14 domain containing 1 |
multiple interactions increases expression |
ISO |
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Rotenone] results in increased expression of FUNDC1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Rotenone results in decreased expression of FUNDC1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of FUNDC1 protein |
CTD |
PMID:32001317 PMID:37156403 |
|
NCBI chr X:5,083,635...5,100,293
Ensembl chr X:5,083,617...5,100,284
|
|
G |
G0s2 |
G0/G1switch 2 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of G0S2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
|
|
G |
Gabarapl1 |
GABA type A receptor associated protein like 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GABARAPL1 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450
|
|
G |
Gabbr2 |
gamma-aminobutyric acid type B receptor subunit 2 |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction and affects the localization of [PSMC5 protein binds to GABBR2 protein] |
CTD |
PMID:24482233 |
|
NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
|
|
G |
Gad1 |
glutamate decarboxylase 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen deficiency results in decreased expression of GAD1 protein] |
CTD |
PMID:29107683 |
|
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
|
|
G |
Gad2 |
glutamate decarboxylase 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen deficiency results in decreased expression of GAD2 protein] |
CTD |
PMID:29107683 |
|
NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
|
|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GADD45A mRNA |
CTD |
PMID:20061341 PMID:25566086 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
|
|
G |
Gadd45g |
growth arrest and DNA-damage-inducible, gamma |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of GADD45G mRNA |
CTD |
PMID:25566086 |
|
NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases expression |
ISO |
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLC mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLC protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC protein]; NFE2L2 protein promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GCLC mRNA] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GCLC mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GCLC protein |
CTD |
PMID:25263748 PMID:30186748 PMID:33434570 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GCLM mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GCLM mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GCLM protein [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLM mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLM protein |
CTD |
PMID:20061341 PMID:33434570 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Gdf15 |
growth differentiation factor 15 |
multiple interactions increases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GDF15 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
|
|
G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
EXP ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [antofine results in decreased expression of GJA1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ioxynil analog results in decreased expression of GJA1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ioxynil results in decreased expression of GJA1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of GJA1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [fulvestrant results in decreased expression of GJA1 protein] |
CTD |
PMID:15685554 PMID:20510257 PMID:23403203 PMID:29180066 |
|
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
|
|
G |
Gja5 |
gap junction protein, alpha 5 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of GJA5 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
|
|
G |
Gls |
glutaminase |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [diphenylarsinic acid results in increased degradation of GLS protein alternative form] |
CTD |
PMID:22493432 |
|
NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
|
|
G |
Gpr146 |
G protein-coupled receptor 146 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of GPR146 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr12:15,251,936...15,267,217
Ensembl chr12:15,251,813...15,267,206
|
|
G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions increases expression decreases expression |
ISO |
[sodium arsenite co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of GPX1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in decreased expression of GPX1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [sodium arsenite results in decreased expression of GPX1 mRNA]; sodium arsenite inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of GPX1 protein]; sodium arsenite inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GPX1 mRNA] |
CTD |
PMID:32301004 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
|
|
G |
Gria1 |
glutamate ionotropic receptor AMPA type subunit 1 |
increases localization increases expression |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased localization of GRIA1 protein MG-132 increases expression of Gria1 protein in nucleus accumbens cultured cells |
CTD RGD |
PMID:19674091 PMID:19674091 |
RGD:4107725 |
NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
|
|
G |
Gria2 |
glutamate ionotropic receptor AMPA type subunit 2 |
increases localization increases expression |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased localization of GRIA2 protein MG-132 increases expression of Gria2 protein in nucleus accumbens cultured cells |
CTD RGD |
PMID:19674091 PMID:19674091 |
RGD:4107725 |
NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
|
|
G |
Grip1 |
glutamate receptor interacting protein 1 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GRIP1 mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [GRIP1 protein binds to NR1I3 protein] |
CTD |
PMID:24224465 PMID:25566086 |
|
NCBI chr 7:54,934,856...55,592,274
Ensembl chr 7:54,934,250...55,592,273
|
|
G |
Gsdmd |
gasdermin D |
multiple interactions |
ISO |
[lipopolysaccharide, Escherichia coli O111 B4 co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of and results in increased cleavage of GSDMD protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of GSDMD protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of and results in increased cleavage of GSDMD protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of GSDMD protein] |
CTD |
PMID:34920032 |
|
NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
|
|
G |
Gsg1l |
GSG1-like |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of GSG1L mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 1:180,440,398...180,654,342
Ensembl chr 1:180,442,630...180,654,134
|
|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions increases phosphorylation decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Estradiol inhibits the reaction [ESR1 protein binds to GSK3B protein]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of GSK3B protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of GSK3B protein modified form |
CTD |
PMID:24085292 PMID:26990689 PMID:30703377 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
|
|
G |
Gsr |
glutathione-disulfide reductase |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSR mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSR mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSR protein [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GSR mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GSR protein |
CTD |
PMID:20061341 PMID:33434570 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Gss |
glutathione synthetase |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSS mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
|
|
G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSTA2 mRNA |
CTD |
PMID:12446695 PMID:20061341 |
|
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
|
|
G |
Gsta5 |
glutathione S-transferase alpha 5 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Lead results in increased expression of GSTA1 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Mercury results in increased expression of GSTA1 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide promotes the reaction [Copper results in decreased expression of GSTA1 mRNA]] |
CTD |
PMID:16243960 |
|
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
|
|
G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSTM1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSTM5 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
|
|
G |
Gstm2 |
glutathione S-transferase mu 2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSTM2 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
|
|
G |
Gstm5 |
glutathione S-transferase, mu 5 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSTM3 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
|
|
G |
Gsto1 |
glutathione S-transferase omega 1 |
multiple interactions increases expression |
ISO |
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GSTO1 mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSTO1 mRNA |
CTD |
PMID:33434570 |
|
NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
|
|
G |
Gsto2 |
glutathione S-transferase omega 2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSTO2 mRNA |
CTD |
PMID:33434570 |
|
NCBI chr 1:246,731,314...246,757,592
Ensembl chr 1:246,732,089...246,753,866
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSTP1 protein |
CTD |
PMID:15863507 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
|
|
G |
Gucy1a1 |
guanylate cyclase 1 soluble subunit alpha 1 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of GUCY1A1 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of GUCY1A1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
|
|
G |
Gyg1 |
glycogenin 1 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of GYG1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 2:102,611,888...102,653,916
Ensembl chr 2:102,598,496...102,653,797
|
|
G |
H19 |
H19 imprinted maternally expressed transcript |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of H19 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
|
|
G |
H2ac10 |
H2A clustered histone 10 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of H2AC10 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr17:41,570,532...41,571,020
Ensembl chr17:41,570,273...41,571,049
|
|
G |
H2ac12 |
H2A clustered histone 12 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of H2AC12 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr17:42,486,415...42,486,880
Ensembl chr17:42,486,415...42,486,941
|
|
G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased expression of H2AX protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Etoposide results in increased expression of H2AX protein] |
CTD |
PMID:17875725 PMID:21227924 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
|
|
G |
Haghl |
hydroxyacylglutathione hydrolase-like |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of HAGHL mRNA |
CTD |
PMID:25566086 |
|
NCBI chr10:14,804,957...14,809,495
Ensembl chr10:14,804,997...14,807,665
|
|
G |
Hax1 |
HCLS1 associated protein X-1 |
affects expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the expression of HAX1 protein |
CTD |
PMID:19763263 |
|
NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714
|
|
G |
Hdac1 |
histone deacetylase 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Particulate Matter results in increased degradation of HDAC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Vehicle Emissions results in increased degradation of HDAC1 protein] |
CTD |
PMID:17395887 PMID:17927689 |
|
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
|
|
G |
Hdac2 |
histone deacetylase 2 |
increases ubiquitination multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of HDAC2 protein [SOD2 protein co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of HDAC2 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Smoke results in increased degradation of and results in decreased expression of HDAC2 protein]; CAT protein inhibits the reaction [[SOD2 protein co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of HDAC2 protein] |
CTD |
PMID:18421014 PMID:24973648 |
|
NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
|
|
G |
Hdac6 |
histone deacetylase 6 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HDAC6 protein results in increased expression of ESRRA protein] |
CTD |
PMID:34524571 |
|
NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441
|
|
G |
Hes1 |
hes family bHLH transcription factor 1 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HES1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
decreases degradation multiple interactions increases expression |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of HIF1A protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Methylmercury Compounds results in decreased expression of HIF1A protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein modified form 3-(4-bromophenyl)-2-(ethylsulfonyl)-6-methylquinoxaline-1,4-dioxide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; [andrographolide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HIF1A protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Oxygen deficiency] affects the expression of HIF1A protein; [Formaldehyde co-treated with pevonedistat co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the folding of HIF1A protein; [Formaldehyde co-treated with VH298 co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the folding of HIF1A protein; [Oxygen deficiency co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the expression of HIF1A protein; [VH298 co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the folding of HIF1A protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [[Apigenin co-treated with Oxygen deficiency] affects the expression of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in increased degradation of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [L-4F peptide inhibits the reaction [INS protein results in increased expression of HIF1A protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [MALAT1 mRNA affects the reaction [sodium arsenite results in increased expression of HIF1A protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HIF1A protein binds to VHL protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [VHL protein binds to HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of HIF1A protein; bruceine D inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein modified form]; diallyl trisulfide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of HIF1A protein]; dictamnine inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Digitoxin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; dihydrotanshinone I inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; genipin affects the reaction [[Oxygen deficiency co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the expression of HIF1A protein]; Glucosamine affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein]; manganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]]; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HIF1A protein binds to VHL protein]]; Resveratrol inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resveratrol results in decreased expression of HIF1A protein]; Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein] |
CTD |
PMID:11980636 PMID:17764071 PMID:17973296 PMID:18682687 PMID:19254699 PMID:19263519 PMID:20335389 PMID:20524035 PMID:20554536 PMID:21134392 PMID:22537771 PMID:23593480 PMID:24221993 PMID:24497960 PMID:24975222 PMID:25192544 PMID:26282490 PMID:27287256 PMID:28574600 PMID:28651835 PMID:29630948 PMID:30266538 PMID:31850806 PMID:32461003 PMID:34717917 PMID:34900531 PMID:35504338 PMID:35513012 More...
|
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
|
|
G |
Higd1b |
HIG1 hypoxia inducible domain family, member 1B |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HIGD1B mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HIGD1B mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr10:87,798,864...87,804,459
|
|
G |
Hipk2 |
homeodomain interacting protein kinase 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [cobaltous chloride results in decreased expression of HIPK2 protein] |
CTD |
PMID:19714248 |
|
NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223
|
|
G |
Hist1h2af |
histone cluster 1 H2A family member F |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of H2AC13 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr17:41,379,404...41,379,796
Ensembl chr17:41,379,404...41,379,796
|
|
G |
Hist1h2ah |
histone cluster 1 H2A family member H |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of H2AC22 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr17:41,384,521...41,385,018
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression increases ubiquitination multiple interactions |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HMOX1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HMOX1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of HMOX1 protein [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in decreased expression of HMOX1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hemin results in decreased expression of HMOX1 protein] [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of HMOX1 mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of HMOX1 protein; [USP7 protein co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HMOX1 protein; [USP7 protein mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HMOX1 protein; Arsenic inhibits the reaction [[USP7 protein mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HMOX1 protein]; Arsenic inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of HMOX1 protein]; Arsenic promotes the reaction [[USP7 protein co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HMOX1 protein]; Arsenic promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HMOX1 protein binds to USP7 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hemin results in increased expression of HMOX1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HMOX1 protein binds to USP7 protein]; HMOX1 protein inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HMOX1 mRNA]; USP7 protein affects the reaction [Arsenic inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of HMOX1 protein]]; USP7 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of HMOX1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HMOX1 mRNA] |
CTD |
PMID:12441344 PMID:18550526 PMID:18835339 PMID:25824035 PMID:30186748 PMID:33434570 PMID:35821281 More...
|
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hnrnpa1 |
heterogeneous nuclear ribonucleoprotein A1 |
multiple interactions increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetracaine results in decreased expression of HNRNPA1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Thapsigargin affects the localization of HNRNPA1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tunicamycin affects the localization of HNRNPA1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HNRNPA1 mRNA |
CTD |
PMID:23106379 PMID:34822839 |
|
NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
|
|
G |
Hnrnpk |
heterogeneous nuclear ribonucleoprotein K |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [NSC606985 results in decreased expression of HNRNPK protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [PRKCD protein results in increased ubiquitination of HNRNPK protein] |
CTD |
PMID:19747914 |
|
NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
|
|
G |
Hopx |
HOP homeobox |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of HOPX mRNA |
CTD |
PMID:25566086 |
|
NCBI chr14:31,055,912...31,082,909
Ensembl chr14:31,075,148...31,082,909
|
|
G |
Hp |
haptoglobin |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HP mRNA |
CTD |
PMID:20061341 |
|
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
|
|
G |
Hr |
HR, lysine demethylase and nuclear receptor corepressor |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HR mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313
|
|
G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Progesterone results in increased expression of HSD11B2 mRNA] |
CTD |
PMID:15857753 |
|
NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
|
|
G |
Hsf1 |
heat shock transcription factor 1 |
increases activity multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of HSF1 protein HSF1 promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPA4 mRNA]; HSF1 promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of UBC mRNA] |
CTD |
PMID:11893605 PMID:30186748 |
|
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
|
|
G |
Hsf2 |
heat shock transcription factor 2 |
increases activity increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of HSF2 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSF2 protein Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSF2 protein] |
CTD |
PMID:11893605 PMID:15914627 |
|
NCBI chr20:36,819,864...36,847,490
Ensembl chr20:36,819,864...36,850,174
|
|
G |
Hsf4 |
heat shock transcription factor 4 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSF4 protein Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSF4 protein] |
CTD |
PMID:15914627 |
|
NCBI chr19:33,147,755...33,153,479
Ensembl chr19:33,147,755...33,153,479
|
|
G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSP90AA1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
|
|
G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
multiple interactions increases expression |
EXP ISO |
PARK7 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPA1A protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPA1A mRNA |
CTD |
PMID:18331584 PMID:25566086 |
|
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
|
|
G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPA1B mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPA1B protein |
CTD |
PMID:15525353 PMID:25566086 |
|
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
|
|
G |
Hspa4 |
heat shock protein family A (Hsp70) member 4 |
multiple interactions increases expression |
ISO |
Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPA4 protein] HSF1 promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPA4 mRNA] |
CTD |
PMID:15914627 PMID:30186748 |
|
NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
|
|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPA5 protein |
CTD |
PMID:19139269 PMID:21692457 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
|
|
G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of HSPA8 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
|
|
G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Acrylamide results in decreased expression of HSPA9 protein] |
CTD |
PMID:37353096 |
|
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
|
|
G |
Hspb1 |
heat shock protein family B (small) member 1 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPB1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPB1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [bufalin results in decreased expression of HSPB1 protein] Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPB1 protein] |
CTD |
PMID:15914627 PMID:23091618 |
|
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
|
|
G |
Hspb2 |
heat shock protein family B (small) member 2 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HSPB2 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HSPB2 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 8:51,093,267...51,094,528
Ensembl chr 8:51,081,342...51,094,533
|
|
G |
Hsph1 |
heat shock protein family H (Hsp110) member 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPH1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
|
|
G |
Htra2 |
HtrA serine peptidase 2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HTRA2 protein |
CTD |
PMID:19763263 |
|
NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions decreases expression |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] MG132 pretreatment decreases expression of protein in liver of intestinal ischemia/reperfusion rats |
CTD RGD |
PMID:11698246 PMID:14572618 PMID:22079846 |
RGD:401794136 |
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP6 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP8 protein]; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP1 protein]]; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP6 protein]]; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IFNG protein results in increased activity of CASP8 protein]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]] |
CTD |
PMID:15914627 PMID:19393675 PMID:23395999 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G |
Igf1r |
insulin-like growth factor 1 receptor |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [platycodin D results in decreased expression of IGF1R protein] |
CTD |
PMID:28711525 |
|
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
|
|
G |
Igf2 |
insulin-like growth factor 2 |
multiple interactions decreases response to substance |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IGF2 protein results in increased expression of STS protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased susceptibility to IGF2 protein |
CTD |
PMID:24055520 |
|
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
|
|
G |
Il18 |
interleukin 18 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein] [lipopolysaccharide, Escherichia coli O111 B4 co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of IL18 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of IL18 protein] |
CTD |
PMID:15178407 PMID:34920032 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
|
|
G |
Il1a |
interleukin 1 alpha |
multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of IL1A mRNA |
CTD |
PMID:11230753 PMID:15728660 PMID:20061341 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions decreases response to substance |
ISO EXP |
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with IL1B protein] results in increased expression of and results in increased phosphorylation of NFKBIA protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of IL1B protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of IL1B protein]; sodium arsenite inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with IL1B protein] results in increased expression of and results in increased phosphorylation of NFKBIA protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased susceptibility to IL1B protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA] |
CTD |
PMID:10541287 PMID:11835394 PMID:14581482 PMID:19393675 PMID:23395999 PMID:34920032 More...
|
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
increases expression decreases expression multiple interactions |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of IL6 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of IL6 protein MG132 pretreatment decreases expression of TNFa, IL6 protein in serum of intestinal ischemia/reperfusion rats benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein] Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of IL6 protein] |
CTD RGD |
PMID:11893605 PMID:18457675 PMID:28134560 PMID:31806706 PMID:22079846 |
RGD:401794136 |
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Impact |
impact RWD domain protein |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of IMPACT mRNA |
CTD |
PMID:25566086 |
|
NCBI chr18:4,108,872...4,147,571
Ensembl chr18:4,108,853...4,147,569
|
|
G |
Inafm2 |
InaF motif containing 2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of INAFM2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 3:105,728,208...105,733,766
|
|
G |
Ins1 |
insulin 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [INS1 protein results in decreased expression of IRS1 protein] |
CTD |
PMID:24219910 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
|
|
G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [L-4F peptide inhibits the reaction [INS protein results in increased expression of HIF1A protein]] |
CTD |
PMID:22537771 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
|
|
G |
Insl6 |
insulin-like 6 |
multiple interactions increases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of INSL6 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 1:227,069,958...227,073,493
Ensembl chr 1:227,069,958...227,073,493
|
|
G |
Irf8 |
interferon regulatory factor 8 |
decreases degradation |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of IRF8 protein |
CTD |
PMID:15837792 |
|
NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829
|
|
G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [INS1 protein results in decreased expression of IRS1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in decreased expression of IRS1 protein] |
CTD |
PMID:24219910 PMID:32061799 |
|
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
|
|
G |
Irx3 |
iroquois homeobox 3 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of IRX3 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr19:15,211,882...15,215,317
Ensembl chr19:15,211,878...15,215,317
|
|
G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tretinoin results in increased expression of ITGAM protein] |
CTD |
PMID:20945414 |
|
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
|
|
G |
Itgb1bp2 |
integrin subunit beta 1 binding protein 2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ITGB1BP2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr X:66,572,537...66,577,174
Ensembl chr X:66,572,537...66,577,174
|
|
G |
Itgb3 |
integrin subunit beta 3 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [GW 4064 results in decreased expression of ITGB3 protein] |
CTD |
PMID:38216027 |
|
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
|
|
G |
Itpr3 |
inositol 1,4,5-trisphosphate receptor, type 3 |
multiple interactions |
EXP ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Acrylamide results in decreased expression of ITPR3 protein] |
CTD |
PMID:37353096 |
|
NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337
|
|
G |
Ivl |
involucrin |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of IVL mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of JUN protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [KU-32 compound inhibits the reaction [NRG1 protein results in increased expression of and results in increased phosphorylation of JUN protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NRG1 protein results in increased expression of and results in increased phosphorylation of JUN protein]; Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of JUN protein] |
CTD |
PMID:23240583 PMID:23593480 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUNB protein]] |
CTD |
PMID:17148446 |
|
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
|
|
G |
Kat5 |
lysine acetyltransferase 5 |
multiple interactions increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [KAT5 protein results in increased acetylation of and results in increased degradation of SRSF2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in decreased expression of KAT5 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of KAT5 protein |
CTD |
PMID:21157427 PMID:28837777 |
|
NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458
|
|
G |
Katnb1 |
katanin regulatory subunit B1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of KATNB1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr19:9,921,216...9,940,853
Ensembl chr19:9,921,219...9,940,650
|
|
G |
Kbtbd11 |
kelch repeat and BTB domain containing 11 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of KBTBD11 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr16:74,618,291...74,638,010
Ensembl chr16:74,615,792...74,637,736
|
|
G |
Kcng2 |
potassium voltage-gated channel modifier subfamily G member 2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of KCNG2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr18:73,742,224...73,810,420
Ensembl chr18:73,743,074...73,808,723
|
|
G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [arsenic trioxide results in increased degradation of KCNH2 protein] |
CTD |
PMID:28521025 |
|
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
|
|
G |
Kcnip3 |
potassium voltage-gated channel interacting protein 3 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[SOD1 protein results in increased susceptibility to Thimerosal] which results in decreased expression of KCNIP3 protein] |
CTD |
PMID:30503815 |
|
NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556
|
|
G |
Kcnn2 |
potassium calcium-activated channel subfamily N member 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [FBXO32 protein results in decreased expression of KCNN2 protein] |
CTD |
PMID:30635400 |
|
NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
|
|
G |
Kdm1a |
lysine demethylase 1A |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SP2509 results in decreased stability of KDM1A protein] |
CTD |
PMID:29581250 |
|
NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319
|
|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
[2-tert-butylhydroquinone co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NFE2L2 protein binds to KEAP1 protein] |
CTD |
PMID:18512965 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
|
|
G |
Kif1a |
kinesin family member 1A |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of KIF1A mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of KIF1A mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 9:93,563,033...93,647,412
Ensembl chr 9:93,563,045...93,647,480
|
|
G |
Kif1b |
kinesin family member 1B |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of KIF1B mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778
|
|
G |
Kif20a |
kinesin family member 20A |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of KIF20A mRNA |
CTD |
PMID:20061341 |
|
NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
|
|
G |
Kif4a |
kinesin family member 4A |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of KIF4 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr X:65,721,746...65,824,277
Ensembl chr X:65,721,779...65,824,139
|
|
G |
Klf2 |
KLF transcription factor 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TRAF2 protein results in decreased expression of KLF2 protein] |
CTD |
PMID:35635602 |
|
NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
|
|
G |
Klf6 |
KLF transcription factor 6 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of KLF6 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
|
|
G |
Klhl6 |
kelch-like family member 6 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of KLHL6 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr11:80,970,917...81,010,593
Ensembl chr11:80,970,917...81,009,677
|
|
G |
Knstrn |
kinetochore-localized astrin/SPAG5 binding protein |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of KNSTRN mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 3:105,800,762...105,820,555
Ensembl chr 3:105,800,954...105,820,715
|
|
G |
Kras |
KRAS proto-oncogene, GTPase |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of KRAS mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 4:178,185,418...178,218,484
|
|
G |
Krt5 |
keratin 5 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [Diacetyl affects the expression of and affects the ubiquitination of KRT5 protein] |
CTD |
PMID:32112875 |
|
NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850
|
|
G |
Ky |
kyphoscoliosis peptidase |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of KY mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 8:103,086,959...103,126,305
Ensembl chr 8:103,086,630...103,126,024
|
|
G |
Lat2 |
linker for activation of T cells family, member 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in decreased expression of LAT2 protein] |
CTD |
PMID:23001822 |
|
NCBI chr12:22,104,173...22,118,294
Ensembl chr12:22,104,219...22,118,288
|
|
G |
Ldb3 |
LIM domain binding 3 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of LDB3 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr16:9,855,768...9,920,108
Ensembl chr16:9,855,927...9,918,532
|
|
G |
Lgals1 |
galectin 1 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of LGALS1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
|
|
G |
Lmo7 |
LIM domain 7 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of LMO7 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783
|
|
G |
Lnx1 |
ligand of numb-protein X 1 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of LNX1 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr14:33,514,429...33,617,086
Ensembl chr14:33,514,436...33,617,086
|
|
G |
Lpin1 |
lipin 1 |
multiple interactions increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TGFB1 protein results in decreased expression of LPIN1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of LPIN1 protein |
CTD |
PMID:27345520 |
|
NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
|
|
G |
Lrrc10 |
leucine-rich repeat-containing 10 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of LRRC10 mRNA [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of LRRC10 mRNA; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of LRRC10 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 7:52,686,972...52,688,369
Ensembl chr 7:52,686,972...52,688,369
|
|
G |
Lrrc75a |
leucine rich repeat containing 75A |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of LRRC75A mRNA |
CTD |
PMID:25566086 |
|
NCBI chr10:47,298,222...47,343,301
Ensembl chr10:47,297,288...47,343,664
|
|
G |
Lrrk2 |
leucine-rich repeat kinase 2 |
increases ubiquitination |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of LRRK2 protein |
CTD |
PMID:24942733 |
|
NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703
|
|
G |
Luc7l |
LUC7-like |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of LUC7L mRNA |
CTD |
PMID:25566086 |
|
NCBI chr10:15,273,340...15,307,131
Ensembl chr10:15,273,348...15,303,112
|
|
G |
Lxn |
latexin |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of LXN mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of LXN mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460
|
|
G |
Maf1 |
MAF1 homolog, negative regulator of RNA polymerase III |
multiple interactions |
ISO |
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Sirolimus] results in decreased degradation of MAF1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of and results in decreased degradation of MAF1 protein; CUL2 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of MAF1 protein] |
CTD |
PMID:31645432 |
|
NCBI chr 7:108,075,173...108,078,252
Ensembl chr 7:108,075,189...108,078,249
|
|
G |
Map1b |
microtubule-associated protein 1B |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MAP1B mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MAP1B mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
|
|
G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MAP1LC3B protein modified form benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [trovafloxacin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; MAP1LC3B protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:24085292 PMID:26409479 PMID:33609687 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:25780039 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:25780039 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation decreases response to substance multiple interactions |
EXP ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of MAPK8 protein MAPK8 gene mutant form results in decreased susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde MAPK8 affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PMAIP1 mRNA] |
CTD |
PMID:18463101 PMID:23593480 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
MAPK9 inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PMAIP1 mRNA] |
CTD |
PMID:23593480 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
|
|
G |
Mapkapk2 |
MAPK activated protein kinase 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Benzo(a)pyrene results in increased degradation of MAPKAPK2 protein] |
CTD |
PMID:35427736 |
|
NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
|
|
G |
Marchf6 |
membrane associated ring-CH-type finger 6 |
increases stability |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased stability of MARCHF6 protein |
CTD |
PMID:30545937 |
|
NCBI chr 2:82,455,686...82,532,917
Ensembl chr 2:82,455,689...82,532,910
|
|
G |
Masp1 |
MBL associated serine protease 1 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MASP1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974
|
|
G |
Mb |
myoglobin |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MB mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MB mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
|
|
G |
Mbd2 |
methyl-CpG binding domain protein 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of MBD2 protein] |
CTD |
PMID:23395981 |
|
NCBI chr18:64,174,002...64,240,795
Ensembl chr18:64,174,002...64,240,794
|
|
G |
Mbd3 |
methyl-CpG binding domain protein 3 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of MBD3 protein] |
CTD |
PMID:23395981 |
|
NCBI chr 7:9,312,961...9,320,166
Ensembl chr 7:9,313,098...9,320,165
|
|
G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions increases expression decreases degradation increases ubiquitination |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Resveratrol co-treated with Clofarabine] results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Sorafenib co-treated with PRKN protein] results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arsenic Trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arsenic Trioxide results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [arsenite results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Clofarabine promotes the reaction [Resveratrol results in decreased expression of MCL1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Daunorubicin results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Metformin results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [NVP-BKM120 results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Quercetin results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Resveratrol promotes the reaction [Clofarabine results in decreased expression of MCL1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Sirolimus inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [USP7 protein affects the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[Resveratrol co-treated with Clofarabine] results in increased expression of MCL1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MCL1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of MCL1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of MCL1 protein |
CTD |
PMID:16109713 PMID:17553788 PMID:20802529 PMID:21750559 PMID:21933852 PMID:23082001 PMID:23341456 PMID:23353698 PMID:24924397 PMID:25408576 PMID:28673964 PMID:32305283 PMID:32802178 PMID:34963561 PMID:35561756 PMID:36346691 PMID:38479708 More...
|
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
|
|
G |
Mcm5 |
minichromosome maintenance complex component 5 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of MCM5 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
|
|
G |
Mdm2 |
MDM2 proto-oncogene |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MDM2 mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]] |
CTD |
PMID:17575151 PMID:20061341 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
|
|
G |
Mecp2 |
methyl CpG binding protein 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of MECP2 protein] |
CTD |
PMID:23395981 |
|
NCBI chr X:151,781,177...151,844,687
Ensembl chr X:151,789,930...151,844,689
|
|
G |
Mgarp |
mitochondria-localized glutamic acid-rich protein |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MGARP mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 2:135,431,283...135,439,425
Ensembl chr 2:135,431,283...135,439,612
|
|
G |
Mgll |
monoglyceride lipase |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MGLL mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179
|
|
G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tamoxifen results in increased degradation of MGMT protein] |
CTD |
PMID:17597106 |
|
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
|
|
G |
Mgst1 |
microsomal glutathione S-transferase 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MGST1 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
|
|
G |
Mir122 |
microRNA 122 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MIR122 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr18:58,758,703...58,758,787
|
|
G |
Mir146a |
microRNA 146a |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MIR146A |
CTD |
PMID:32392329 |
|
NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
|
|
G |
Mitf |
melanocyte inducing transcription factor |
multiple interactions decreases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MITF mRNA |
CTD |
PMID:29486182 PMID:31806706 |
|
NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
|
|
G |
Mlkl |
mixed lineage kinase domain like pseudokinase |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MLKL mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MLKL mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502
|
|
G |
Mllt11 |
MLLT11, transcription factor 7 cofactor |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MLLT11 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:182,795,790...182,797,199
|
|
G |
Mmp13 |
matrix metallopeptidase 13 |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [halofuginone results in increased expression of MMP13 mRNA] |
CTD |
PMID:16489207 |
|
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
|
|
G |
Mmp23 |
matrix metallopeptidase 23 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of MMP23 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 5:166,239,643...166,242,734
Ensembl chr 5:166,239,644...166,242,433
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [butein results in decreased expression of MMP9 protein] |
CTD |
PMID:15728660 PMID:20696233 PMID:24613819 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Mocos |
molybdenum cofactor sulfurase |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MOCOS mRNA |
CTD |
PMID:20061341 PMID:25566086 |
|
NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187
|
|
G |
Mocs1 |
molybdenum cofactor synthesis 1 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MOCS1 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MOCS1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 9:11,547,533...11,573,935
Ensembl chr 9:11,547,531...11,567,790
|
|
G |
Mocs2 |
molybdenum cofactor synthesis 2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MOCS2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 2:46,504,588...46,516,327
Ensembl chr 2:46,504,588...46,516,324
|
|
G |
Mt3 |
metallothionein 3 |
multiple interactions increases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MT3 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
|
|
G |
Mterf3 |
mitochondrial transcription termination factor 3 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide results in decreased expression of MTERF3 protein] |
CTD |
PMID:35904214 |
|
NCBI chr 7:63,826,418...63,844,747
Ensembl chr 7:63,826,427...63,844,658
|
|
G |
Mthfd1 |
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [arsenic trioxide results in increased degradation of MTHFD1 protein] |
CTD |
PMID:28265077 |
|
NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372
|
|
G |
Mtor |
mechanistic target of rapamycin kinase |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MTOR protein |
CTD |
PMID:25897075 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
|
|
G |
Mttp |
microsomal triglyceride transfer protein |
multiple interactions increases expression |
ISO |
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Chloroquine] results in increased expression of MTTP protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MTTP protein |
CTD |
PMID:34516972 |
|
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
|
|
G |
Mtus1 |
microtubule associated scaffold protein 1 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MTUS1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr16:51,202,497...51,347,794
Ensembl chr16:51,253,562...51,347,793
|
|
G |
Muc1 |
mucin 1, cell surface associated |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [MUC1 affects the expression of EGFR protein] |
CTD |
PMID:22457794 |
|
NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
|
|
G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein] |
CTD |
PMID:22766066 |
|
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
|
|
G |
Mybpc3 |
myosin binding protein C3 |
decreases expression affects response to substance multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYBPC3 mRNA MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of BOK mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of CAV1 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of CCNB1 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of CDH3 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of CDK1 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of CKB mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of EGFL7 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of FAHD1 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of G0S2 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of GPR146 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of H2AC10 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of H2AC12 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of H2AC13 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of H2AC15 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of H2AC22 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of H2AC7 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of HAGHL mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of HOPX mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of KBTBD11 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of KY mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of LGALS1 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of LRRC10 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of LRRC75A mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of MCM5 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of MMP23 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of MYL12B mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of MYLK mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of NRM mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PBK mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PDLIM4 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PLEKHG2 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PLK1 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PPARGC1B mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PPP1R3G mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of ROBO4 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of RRM2 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of SYNPO mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of TK1 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of TMEM176A mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of TMEM176B mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of TRIB2 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of ZFYVE21 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of ATG12 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of EIF2AK2 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of FAM13B mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of GADD45G mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of HSPA8 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of LUC7L mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of NRIP3 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of SF1 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of SWT1 mRNA; [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of UFD1 mRNA; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACAA2 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACTC1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ADSS1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of APH1A mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ARG1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ART3 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of C1QB mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CAR14 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CAVIN1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CENPA mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CHRM2 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CKMT2 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CLIP4 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CMYA5 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CORIN mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of EGLN1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of EGLN3 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ENO3 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of FBXO10 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of GSG1L mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of GUCY1A1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of GYG1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of H2-AB1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HES1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HIGD1B mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HR mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HSPB2 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of KLHL6 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of LDB3 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of LMO7 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of LRRC10 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of LXN mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MB mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYBPC3 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYBPHL mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYL1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYL7 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYO5B mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYZAP mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of NACAD mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of NIPSNAP2 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of NMRK2 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PCDH7 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PDK1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PDLIM5 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PERM1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PFKP mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PIP5K1B mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PLAC8 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PPP1R14C mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PRC1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of RARRES2 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SH3KBP1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SNRK mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SPON2 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SPSB4 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SSPN mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TFRC mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of THY1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TMEM204 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TMOD1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TNNI2 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TRIL mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TSC22D4 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of UNC13C mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ZBTB8B mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CD14 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CLDN4 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DNMT3L mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DYNC1H1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GDF15 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of INSL6 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of KIF1A mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MAP1B mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MLKL mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MOCS1 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MT3 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NGF mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PDPN mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SLC6A9 mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SPRR2G mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SYBU mRNA]; MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TENM4 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405
|
|
G |
Mybphl |
myosin binding protein H-like |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYBPHL mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYBPHL mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 2:196,005,297...196,018,826
Ensembl chr 2:196,005,325...196,018,824
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [STK11 mutant form results in increased expression of MYC protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of MYC protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of MYC protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [lobetyolin results in decreased expression of MYC protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [nickel sulfate results in increased degradation of MYC protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tretinoin results in decreased expression of MYC protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MYC protein [arsenite co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of MYC protein; [arsenite co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of MYC protein modified form; arsenite inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of MYC protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of MYC protein; Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of MYC protein]; Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MYC protein]; FBXW7 protein promotes the reaction [NFKB1 gene mutant form inhibits the reaction [arsenite inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of MYC protein]]]]; NFKB1 gene mutant form inhibits the reaction [arsenite inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of MYC protein]]] |
CTD |
PMID:20046830 PMID:20945414 PMID:21472727 PMID:23593480 PMID:24457827 PMID:24793789 PMID:25897075 PMID:28548306 PMID:34075790 More...
|
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
|
|
G |
Myh6 |
myosin heavy chain 6 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYH6 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
|
|
G |
Myl1 |
myosin, light chain 1 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYL1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261
|
|
G |
Myl12b |
myosin light chain 12B |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of MYL12B mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 9:110,873,855...110,888,187
|
|
G |
Myl7 |
myosin light chain 7 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYL7 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYL7 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr14:80,780,684...80,783,259
Ensembl chr14:80,779,776...80,783,244
|
|
G |
Mylk |
myosin light chain kinase |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of MYLK mRNA |
CTD |
PMID:25566086 |
|
NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
|
|
G |
Mylk3 |
myosin light chain kinase 3 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYLK3 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr19:21,685,085...21,743,587
Ensembl chr19:21,691,929...21,742,954
|
|
G |
Myo5b |
myosin Vb |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYO5B mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYO5B mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr18:68,038,759...68,341,568
Ensembl chr18:68,038,759...68,338,745
|
|
G |
Myzap |
myocardial zonula adherens protein |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYZAP mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYZAP mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 8:72,155,817...72,243,036
Ensembl chr 8:72,131,530...72,243,036
|
|
G |
Nacad |
NAC alpha domain containing |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of NACAD mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of NACAD mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr14:81,465,299...81,473,866
Ensembl chr14:81,465,299...81,473,781
|
|
G |
Nanog |
Nanog homeobox |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resveratrol results in decreased expression of NANOG protein] |
CTD |
PMID:23651583 |
|
NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
|
|
G |
Napb |
NSF attachment protein beta |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NAPB mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 3:136,132,248...136,179,280
Ensembl chr 3:136,133,428...136,179,345
|
|
G |
Ncoa1 |
nuclear receptor coactivator 1 |
increases expression |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NCOA1 protein |
CTD |
PMID:16564422 |
|
NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
|
|
G |
Ncoa3 |
nuclear receptor coactivator 3 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased degradation of NCOA3 protein] |
CTD |
PMID:16456540 |
|
NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594
|
|
G |
Ncor1 |
nuclear receptor co-repressor 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased stability of and results in increased expression of NCOR1 protein |
CTD |
PMID:15857753 |
|
NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
|
|
G |
Ncor2 |
nuclear receptor co-repressor 2 |
multiple interactions increases expression |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased stability of and results in increased expression of NCOR2 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NCOR2 protein |
CTD |
PMID:15857753 PMID:16564422 |
|
NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319
|
|
G |
Ndfip1 |
Nedd4 family interacting protein 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [NDFIP1 protein results in decreased expression of SLC6A3 protein] |
CTD |
PMID:26300475 |
|
NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311
|
|
G |
Nedd4l |
NEDD4 like E3 ubiquitin protein ligase |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NEDD4L mRNA |
CTD |
PMID:20061341 |
|
NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137
|
|
G |
Neurl2 |
neuralized E3 ubiquitin protein ligase 2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of NEURL2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 3:153,566,659...153,569,380
Ensembl chr 3:153,566,660...153,569,380
|
|
G |
Nfat5 |
nuclear factor of activated T-cells 5 |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased degradation of NFAT5 protein] |
CTD |
PMID:17105721 |
|
NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675
|
|
G |
Nfe2l1 |
NFE2 like bZIP transcription factor 1 |
decreases degradation multiple interactions increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of NFE2L1 protein alternative form benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Glucose results in increased expression of NFE2L1 protein]; Glucose promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L1 protein]; Metformin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L1 protein] |
CTD |
PMID:28549828 PMID:33838154 |
|
NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions decreases expression increases ubiquitination decreases degradation increases expression increases activity |
ISO EXP |
2-tert-butyl-4-quinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of and affects the localization of NFE2L2 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of NFE2L2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Glucose results in increased expression of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [sulforaphane results in increased expression of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of and affects the localization of NFE2L2 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of and results in increased stability of and results in increased ubiquitination of NFE2L2 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased localization of and results in increased activity of NFE2L2 protein; Curcumin inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 protein]]; cyanoginosin LR inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein]; Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 protein]; hydroquinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein]; Metformin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 protein]; NFE2L2 protein promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GCLC mRNA]; NFE2L2 protein promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HMOX1 mRNA]; quinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of NFE2L2 protein modified form benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of NFE2L2 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [triptolide affects the expression of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [NFE2L2 protein inhibits the reaction [Streptozocin results in increased expression of USP15 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in increased ubiquitination of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [sulforaphane results in increased activity of NFE2L2 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of NFE2L2 protein [2-tert-butylhydroquinone co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of and results in increased ubiquitination of NFE2L2 protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 2-tert-butylhydroquinone] results in increased expression of NFE2L2 protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Cycloheximide] results in increased expression of NFE2L2 protein; baicalin inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased ubiquitination of NFE2L2 protein]; baicalin promotes the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Particulate Matter analog results in increased expression of NFE2L2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Vehicle Emissions analog results in increased expression of NFE2L2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [2-tert-butylhydroquinone results in increased ubiquitination of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride affects the ubiquitination of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of and affects the localization of NFE2L2 protein; Exenatide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein] [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 protein] which results in increased expression of CBR3 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 protein |
CTD |
PMID:12441344 PMID:12446695 PMID:14510636 PMID:15319326 PMID:15322212 PMID:18512965 PMID:18550526 PMID:19786557 PMID:20722399 PMID:20806931 PMID:22019695 PMID:22558124 PMID:22606287 PMID:22964297 PMID:25263748 PMID:26598004 PMID:27939242 PMID:28645578 PMID:29618784 PMID:30186748 PMID:30703377 PMID:30926361 PMID:31319135 PMID:31806706 PMID:33434570 PMID:33838154 PMID:34758851 PMID:35478295 PMID:38016618 More...
|
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased activity of [NFKB1 protein binds to RELA protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]; FBXW7 protein promotes the reaction [NFKB1 gene mutant form inhibits the reaction [arsenite inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of MYC protein]]]]; NFKB1 gene mutant form inhibits the reaction [arsenite inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of MYC protein]]] |
CTD |
PMID:11543732 PMID:14527959 PMID:14581482 PMID:16026644 PMID:24457827 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions increases expression increases phosphorylation |
ISO EXP |
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with IL1B protein] results in increased expression of and results in increased phosphorylation of NFKBIA protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with TNF protein] results in increased phosphorylation of NFKBIA protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased degradation of NFKBIA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [osthol results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Deoxycholic Acid results in increased phosphorylation of NFKBIA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of and results in increased degradation of NFKBIA protein; MAP1LC3B protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of NFKBIA protein]; sodium arsenite inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with IL1B protein] results in increased expression of and results in increased phosphorylation of NFKBIA protein]; TNF protein affects the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Thiopental] affects the phosphorylation of NFKBIA protein] MG132 pretreatment increases expression of protein in liver of intestinal ischemia/reperfusion rats benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFKBIA protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ammonium Chloride results in increased degradation of NFKBIA protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zymosan results in increased degradation of NFKBIA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zymosan results in increased phosphorylation of NFKBIA protein] |
CTD RGD |
PMID:11543732 PMID:11698246 PMID:11835394 PMID:11923223 PMID:12185005 PMID:12628480 PMID:12721113 PMID:12883408 PMID:15477007 PMID:16421291 PMID:17644113 PMID:20005289 PMID:22503731 PMID:23423712 PMID:24085292 PMID:25780039 PMID:22079846 More...
|
RGD:401794136 |
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nfkbib |
NFKB inhibitor beta |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein] |
CTD |
PMID:11543732 |
|
NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
|
|
G |
Nfkbie |
NFKB inhibitor epsilon |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIE protein] |
CTD |
PMID:12185005 |
|
NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437
|
|
G |
Ngf |
nerve growth factor |
multiple interactions increases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NGF mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
|
|
G |
Ngly1 |
N-glycanase 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NGLY1 protein binds to UBXN1 protein] |
CTD |
PMID:15362974 |
|
NCBI chr15:9,153,738...9,210,228
Ensembl chr15:9,153,738...9,204,630
|
|
G |
Nipsnap2 |
nipsnap homolog 2 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of NIPSNAP2 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of NIPSNAP2 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr12:26,906,068...26,944,201
Ensembl chr12:26,911,723...26,944,166
|
|
G |
Nme3 |
NME/NM23 nucleoside diphosphate kinase 3 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of NME3 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr10:13,917,309...13,918,415
Ensembl chr10:13,917,403...13,918,359
|
|
G |
Nmrk2 |
nicotinamide riboside kinase 2 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of NMRK2 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of NMRK2 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 7:8,514,855...8,517,916
Ensembl chr 7:8,514,927...8,517,922
|
|
G |
Nol3 |
nucleolar protein 3 |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [Doxorubicin results in increased degradation of NOL3 protein] |
CTD |
PMID:19139834 |
|
NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases expression |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zymosan results in increased expression of NOS2 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ammonium Chloride results in increased expression of NOS2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of NOS2 protein |
CTD |
PMID:11923223 PMID:12628480 PMID:12721113 PMID:17891158 PMID:19376148 PMID:19393675 PMID:20675566 PMID:23395999 More...
|
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nos3 |
nitric oxide synthase 3 |
decreases degradation increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of NOS3 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NOS3 protein |
CTD |
PMID:20229525 PMID:20675566 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
|
|
G |
Notch1 |
notch receptor 1 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NOTCH1 mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arsenic Trioxide results in decreased expression of NOTCH1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptonide results in increased degradation of NOTCH1 protein] |
CTD |
PMID:24497960 PMID:24801890 PMID:31597699 PMID:31866380 |
|
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases expression |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Lead results in increased expression of NQO1 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide promotes the reaction [Copper results in decreased expression of NQO1 mRNA]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NQO1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NQO1 protein [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of NQO1 mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of NQO1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NFE2L2 protein binds to NQO1 promoter] |
CTD |
PMID:16243960 PMID:20061341 PMID:22606287 PMID:30186748 PMID:33434570 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions increases ubiquitination decreases activity increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [DNAJC7 protein results in increased expression of NR1I3 protein]; NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of DNAJC7 protein]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NR1I3 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased activity of NR1I3 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime affects the localization of NR1I3 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein modified form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diethylhexyl Phthalate results in increased activity of NR1I3 protein modified form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [GRIP1 protein binds to NR1I3 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phenobarbital affects the localization of NR1I3 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SRC protein binds to NR1I3 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NR1I3 protein |
CTD |
PMID:24224465 PMID:24789201 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
|
|
G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions increases expression |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dexamethasone results in increased degradation of NR3C1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NR3C1 mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tubacin results in decreased expression of and results in increased degradation of NR3C1 mRNA] |
CTD |
PMID:20619282 PMID:31778773 PMID:31806706 |
|
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
|
|
G |
Nrg1 |
neuregulin 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [KU-32 compound inhibits the reaction [NRG1 protein results in increased expression of and results in increased phosphorylation of JUN protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NRG1 protein results in increased expression of and results in increased phosphorylation of JUN protein] |
CTD |
PMID:23240583 |
|
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
|
|
G |
Nrip3 |
nuclear receptor interacting protein 3 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of NRIP3 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 1:163,789,738...163,815,036
Ensembl chr 1:163,789,738...163,815,600
|
|
G |
Nrm |
nurim |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of NRM mRNA |
CTD |
PMID:25566086 |
|
NCBI chr20:2,888,321...2,892,804
Ensembl chr20:2,877,567...2,891,802
|
|
G |
Nsd2 |
nuclear receptor binding SET domain protein 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [3-deazaneplanocin results in increased degradation of NSD2 protein] |
CTD |
PMID:32001260 |
|
NCBI chr14:76,833,179...76,911,304
Ensembl chr14:76,835,637...76,913,641
|
|
G |
Nuf2 |
NUF2 component of NDC80 kinetochore complex |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of NUF2 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766
|
|
G |
Nupr1 |
nuclear protein 1, transcriptional regulator |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NUPR1 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
|
|
G |
Ogg1 |
8-oxoguanine DNA glycosylase |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TH5487 inhibits the reaction [TGFB1 protein results in increased expression of OGG1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [TGFB1 protein results in increased expression of OGG1 protein] |
CTD |
PMID:35654123 |
|
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
|
|
G |
Opa1 |
OPA1, mitochondrial dynamin like GTPase |
increases expression |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of OPA1 protein alternative form |
CTD |
PMID:20678484 |
|
NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
|
|
G |
Oprd1 |
opioid receptor, delta 1 |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]] |
CTD |
PMID:21600884 |
|
NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
|
|
G |
Osgin1 |
oxidative stress induced growth inhibitor 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of OSGIN1 mRNA |
CTD |
PMID:20061341 PMID:25566086 |
|
NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
|
|
G |
P2rx6 |
purinergic receptor P2X 6 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of P2RX6 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr11:83,439,922...83,450,449
Ensembl chr11:83,439,924...83,450,481
|
|
G |
Park7 |
Parkinsonism associated deglycase |
multiple interactions decreases response to substance |
EXP ISO |
PARK7 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPA1A protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Paraquat results in increased sulfation of and results in increased oxidation of PARK7 protein] PARK7 protein results in decreased susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde |
CTD |
PMID:18331584 PMID:26409479 |
|
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of PARP1 protein |
CTD |
PMID:15498850 PMID:16051428 PMID:18790767 PMID:20100472 PMID:34418242 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Pax2 |
paired box 2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PAX2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 1:243,616,509...243,697,454
Ensembl chr 1:243,616,606...243,695,321
|
|
G |
Pbk |
PDZ binding kinase |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PBK mRNA |
CTD |
PMID:25566086 |
|
NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014
|
|
G |
Pcdh7 |
protocadherin 7 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PCDH7 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PCDH7 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr14:52,471,801...52,901,696
Ensembl chr14:52,475,610...52,902,051 Ensembl chr14:52,475,610...52,902,051
|
|
G |
Pdcd6ip |
programmed cell death 6 interacting protein |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PDCD6IP protein |
CTD |
PMID:21692457 |
|
NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773
|
|
G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PDGFB mRNA |
CTD |
PMID:15728660 PMID:25566086 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
|
|
G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PDK1 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PDK1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
|
|
G |
Pdlim4 |
PDZ and LIM domain 4 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PDLIM4 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr10:38,198,686...38,212,935
Ensembl chr10:38,198,689...38,212,938
|
|
G |
Pdlim5 |
PDZ and LIM domain 5 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PDLIM5 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PDLIM5 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275
|
|
G |
Pdpn |
podoplanin |
multiple interactions increases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PDPN mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
|
|
G |
Pdxp |
pyridoxal phosphatase |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PDXP mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 7:110,472,515...110,477,963
Ensembl chr 7:110,472,515...110,477,963
|
|
G |
Pdyn |
prodynorphin |
decreases secretion |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased secretion of PDYN protein alternative form |
CTD |
PMID:17670969 |
|
NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
|
|
G |
Perm1 |
PPARGC1 and ESRR induced regulator, muscle 1 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PERM1 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PERM1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 5:166,800,030...166,805,323
Ensembl chr 5:166,800,030...166,805,323
|
|
G |
Pfkfb3 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
increases expression |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PFKFB3 protein |
CTD |
PMID:19448625 |
|
NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125
|
|
G |
Pfkp |
phosphofructokinase, platelet |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PFKP mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PFKP mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018
|
|
G |
Pgr |
progesterone receptor |
increases expression |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PGR protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PGR protein alternative form |
CTD |
PMID:15218360 PMID:16564422 |
|
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
|
|
G |
Pin1 |
peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arsenic Trioxide results in decreased expression of PIN1 protein] |
CTD |
PMID:30093655 |
|
NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785
|
|
G |
Pink1 |
PTEN induced kinase 1 |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein] |
CTD |
PMID:20164189 |
|
NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
|
|
G |
Pip5k1b |
phosphatidylinositol-4-phosphate 5-kinase type 1 beta |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PIP5K1B mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 1:221,907,220...222,183,672
Ensembl chr 1:221,914,159...222,183,672
|
|
G |
Pkd1 |
polycystin 1, transient receptor potential channel interacting |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [STA 9090 inhibits the reaction [PKD1 gene mutant form results in increased expression of BRD4 protein]] |
CTD |
PMID:25877301 |
|
NCBI chr10:13,573,779...13,621,138
Ensembl chr10:13,573,021...13,621,128
|
|
G |
Pkig |
cAMP-dependent protein kinase inhibitor gamma |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PKIG mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 3:152,330,477...152,398,085
Ensembl chr 3:152,366,041...152,398,082
|
|
G |
Plac8 |
placenta associated 8 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PLAC8 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr14:9,052,601...9,074,264
Ensembl chr14:9,063,048...9,074,264
|
|
G |
Plekha6 |
pleckstrin homology domain containing A6 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PLEKHA6 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr13:44,614,740...44,754,951
Ensembl chr13:44,615,011...44,754,673
|
|
G |
Plekhg2 |
pleckstrin homology and RhoGEF domain containing G2 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PLEKHG2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 1:83,651,902...83,665,063
Ensembl chr 1:83,647,748...83,665,063
|
|
G |
Plk1 |
polo-like kinase 1 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PLK1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
|
|
G |
Pln |
phospholamban |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PLN mRNA |
CTD |
PMID:25566086 |
|
NCBI chr20:32,629,537...32,639,559
|
|
G |
Plod3 |
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PLOD3 protein |
CTD |
PMID:21692457 |
|
NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960
|
|
G |
Plvap |
plasmalemma vesicle associated protein |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PLVAP mRNA |
CTD |
PMID:25566086 |
|
NCBI chr16:18,184,985...18,197,301
Ensembl chr16:18,184,975...18,197,301
|
|
G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
decreases degradation increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of PMAIP1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PMAIP1 mRNA MAPK8 affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PMAIP1 mRNA]; MAPK9 inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PMAIP1 mRNA] |
CTD |
PMID:20802529 PMID:23593480 PMID:31806706 |
|
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
|
|
G |
Pml |
PML nuclear body scaffold |
decreases degradation |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of PML protein modified form |
CTD |
PMID:26049103 |
|
NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
|
|
G |
Pnpla3 |
patatin-like phospholipase domain containing 3 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PNPLA3 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077
|
|
G |
Pou5f1 |
POU class 5 homeobox 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of POU5F1 protein |
CTD |
PMID:24497960 |
|
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases activity multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of PPARG protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resveratrol results in decreased expression of PPARG protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [rosiglitazone results in decreased expression of PPARG protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [alitretinoin results in increased activity of PPARG protein] |
CTD |
PMID:15707588 PMID:18555852 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
decreases degradation |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of PPARGC1A protein |
CTD |
PMID:20860658 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
|
|
G |
Ppargc1b |
PPARG coactivator 1 beta |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PPARGC1B mRNA |
CTD |
PMID:25566086 |
|
NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
|
|
G |
Ppia |
peptidylprolyl isomerase A |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PPIA mRNA |
CTD |
PMID:15857753 |
|
NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
|
|
G |
Ppl |
periplakin |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PPL mRNA |
CTD |
PMID:20061341 |
|
NCBI chr10:10,450,919...10,496,575
Ensembl chr10:10,450,919...10,496,575
|
|
G |
Ppp1r14c |
protein phosphatase 1, regulatory (inhibitor) subunit 14c |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PPP1R14C mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PPP1R14C mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 1:39,773,403...39,886,970
Ensembl chr 1:39,773,403...39,886,956
|
|
G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PPP1R15A mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide results in decreased expression of PPP1R15A protein] |
CTD |
PMID:19135031 PMID:25566086 PMID:29109149 |
|
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
|
|
G |
Ppp1r3g |
protein phosphatase 1, regulatory subunit 3G |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PPP1R3G mRNA |
CTD |
PMID:25566086 |
|
NCBI chr17:28,874,956...28,878,288
Ensembl chr17:28,876,482...28,877,525
|
|
G |
Prc1 |
protein regulator of cytokinesis 1 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PRC1 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PRC1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
|
|
G |
Prdx1 |
peroxiredoxin 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PRDX1 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
|
|
G |
Prkcb |
protein kinase C, beta |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein] |
CTD |
PMID:17644113 |
|
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
|
|
G |
Prkcd |
protein kinase C, delta |
multiple interactions increases phosphorylation |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NSC606985 results in increased activity of and results in increased cleavage of PRKCD protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [PRKCD protein results in increased ubiquitination of HNRNPK protein]; Glutathione inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of PRKCD protein] |
CTD |
PMID:15707588 PMID:19662097 PMID:19747914 |
|
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
|
|
G |
Prkcsh |
PRKCSH beta subunit of glucosidase II |
increases response to substance |
ISO |
PRKCSH gene mutant form results in increased susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde |
CTD |
PMID:21685914 |
|
NCBI chr 8:20,534,787...20,546,493
Ensembl chr 8:20,534,880...20,546,492
|
|
G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
multiple interactions decreases expression affects expression |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Sorafenib co-treated with PRKN protein] results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [PRKN protein results in decreased expression of SLC11A2 protein alternative form]; Tretinoin affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the expression of PRKN protein alternative form] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PRKN protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PRKN mRNA |
CTD |
PMID:18586549 PMID:20089134 PMID:28673964 PMID:28688199 |
|
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
|
|
G |
Psen1 |
presenilin 1 |
multiple interactions |
ISO |
[PSEN1 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the reaction [Cycloheximide results in decreased expression of RBPJ protein] |
CTD |
PMID:22302987 |
|
NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650
|
|
G |
Psma1 |
proteasome 20S subunit alpha 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMA1 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472
|
|
G |
Psma2 |
proteasome 20S subunit alpha 2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMA2 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr17:50,554,536...50,564,923
Ensembl chr17:50,551,924...50,564,938
|
|
G |
Psma3 |
proteasome 20S subunit alpha 3 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMA3 mRNA |
CTD |
PMID:15525353 PMID:31806706 |
|
NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965
|
|
G |
Psma4 |
proteasome 20S subunit alpha 4 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMA4 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 8:55,340,431...55,347,893
Ensembl chr 8:55,340,386...55,347,890
|
|
G |
Psma5 |
proteasome 20S subunit alpha 5 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMA5 mRNA |
CTD |
PMID:15525353 PMID:31806706 |
|
NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731
|
|
G |
Psma6 |
proteasome 20S subunit alpha 6 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMA6 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554
|
|
G |
Psma7 |
proteasome 20S subunit alpha 7 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMA7 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 3:167,137,279...167,143,626
Ensembl chr 3:167,137,263...167,143,672
|
|
G |
Psmb10 |
proteasome 20S subunit beta 10 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PSMB10 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr19:33,830,958...33,833,442
Ensembl chr19:33,827,229...33,833,626
|
|
G |
Psmb2 |
proteasome 20S subunit beta 2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMB2 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137
|
|
G |
Psmb3 |
proteasome 20S subunit beta 3 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMB3 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521
|
|
G |
Psmb4 |
proteasome 20S subunit beta 4 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMB4 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746
|
|
G |
Psmb5 |
proteasome 20S subunit beta 5 |
increases expression decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMB5 mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PSMB5 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PSMB5 protein [sodium arsenite co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of PSMB5 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased expression of PSMB5 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [sodium arsenite results in decreased expression of PSMB5 protein]; sodium arsenite promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PSMB5 mRNA] |
CTD |
PMID:15525353 PMID:31806706 PMID:32301004 |
|
NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
|
|
G |
Psmb6 |
proteasome 20S subunit beta 6 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMB6 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586
|
|
G |
Psmb7 |
proteasome 20S subunit beta 7 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMB7 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937
|
|
G |
Psmb9 |
proteasome 20S subunit beta 9 |
decreases expression increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PSMB9 mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMB9 mRNA |
CTD |
PMID:20061341 PMID:31806706 |
|
NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
|
|
G |
Psmc1 |
proteasome 26S subunit, ATPase 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMC1 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123
|
|
G |
Psmc2 |
proteasome 26S subunit, ATPase 2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMC2 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185
|
|
G |
Psmc3 |
proteasome 26S subunit, ATPase 3 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMC3 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358
|
|
G |
Psmc4 |
proteasome 26S subunit, ATPase 4 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMC4 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494
|
|
G |
Psmc5 |
proteasome 26S subunit, ATPase 5 |
multiple interactions increases expression |
EXP ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction and affects the localization of [PSMC5 protein binds to GABBR2 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMC5 mRNA |
CTD |
PMID:24482233 PMID:31806706 |
|
NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135
|
|
G |
Psmc6 |
proteasome 26S subunit, ATPase 6 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMC6 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
|
|
G |
Psmd1 |
proteasome 26S subunit, non-ATPase 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMD1 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 9:86,709,714...86,785,213
Ensembl chr 9:86,709,947...86,785,211
|
|
G |
Psmd11 |
proteasome 26S subunit, non-ATPase 11 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMD11 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr10:65,433,853...65,479,774
Ensembl chr10:65,433,853...65,479,766
|
|
G |
Psmd12 |
proteasome 26S subunit, non-ATPase 12 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMD12 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287
|
|
G |
Psmd13 |
proteasome 26S subunit, non-ATPase 13 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMD13 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 1:195,964,617...195,976,895
Ensembl chr 1:195,964,138...195,976,905
|
|
G |
Psmd14 |
proteasome 26S subunit, non-ATPase 14 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMD14 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076
|
|
G |
Psmd2 |
proteasome 26S subunit ubiquitin receptor, non-ATPase 2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMD2 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043
|
|
G |
Psmd3 |
proteasome 26S subunit, non-ATPase 3 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMD3 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr10:83,643,473...83,655,620
Ensembl chr10:83,643,647...83,655,618
|
|
G |
Psmd4 |
proteasome 26S subunit ubiquitin receptor, non-ATPase 4 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein] |
CTD |
PMID:15362974 |
|
NCBI chr 2:182,598,934...182,608,250
Ensembl chr 2:182,598,934...182,608,194
|
|
G |
Psmd6 |
proteasome 26S subunit, non-ATPase 6 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMD6 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr15:11,102,174...11,112,180
Ensembl chr15:11,102,180...11,205,620
|
|
G |
Psmd8 |
proteasome 26S subunit, non-ATPase 8 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMD8 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 1:84,474,377...84,481,209
Ensembl chr 1:84,474,378...84,481,209
|
|
G |
Psme1 |
proteasome activator subunit 1 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PSME1 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890
|
|
G |
Psme2 |
proteasome activator subunit 2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PSME2 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr15:29,078,495...29,082,794
Ensembl chr15:29,078,500...29,082,946
|
|
G |
Psme4 |
proteasome activator subunit 4 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSME4 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr14:104,505,716...104,609,410
Ensembl chr14:104,505,716...104,609,408
|
|
G |
Pten |
phosphatase and tensin homolog |
multiple interactions increases ubiquitination increases expression |
EXP ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zinc Sulfate results in decreased stability of PTEN protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of PTEN protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of PTEN protein modified form benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PTEN protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium results in increased degradation of and results in decreased expression of PTEN protein] |
CTD |
PMID:17684018 PMID:20100827 PMID:24449419 PMID:33256086 |
|
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
|
|
G |
Ptger1 |
prostaglandin E receptor 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein] |
CTD |
PMID:20335389 |
|
NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559
|
|
G |
Ptges3 |
prostaglandin E synthase 3 |
decreases degradation multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of PTGES3 protein 4-tosylcyclonovobiocic acid promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of PTGES3 protein] |
CTD |
PMID:19118525 |
|
NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zymosan results in increased expression of PTGS2 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased secretion of PTGS2 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PTGS2 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PTGS2 protein |
CTD |
PMID:11230753 PMID:12628480 PMID:12721113 PMID:17084486 PMID:18457675 PMID:22767315 PMID:24085292 More...
|
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Ptk2b |
protein tyrosine kinase 2 beta |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [PTK2B protein affects the ubiquitination of ESR1 protein] |
CTD |
PMID:29428397 |
|
NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
|
|
G |
Ptp4a3 |
protein tyrosine phosphatase 4A3 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PTP4A3 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 7:105,650,640...105,660,921
Ensembl chr 7:105,628,029...105,660,919
|
|
G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
multiple interactions |
ISO |
PTPN1 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:28359145 |
|
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
|
|
G |
Rab33a |
RAB33A, member RAS oncogene family |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of RAB33A mRNA |
CTD |
PMID:25566086 |
|
NCBI chr X:127,694,219...127,706,378
Ensembl chr X:127,694,964...127,706,378
|
|
G |
Rabl6 |
RAB, member RAS oncogene family-like 6 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of RABL6 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 3:8,402,666...8,428,588
Ensembl chr 3:8,402,672...8,428,611
|
|
G |
Rad51 |
RAD51 recombinase |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] |
CTD |
PMID:21810436 |
|
NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
|
|
G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[arsenic trioxide co-treated with PD 173074] results in decreased expression of RAF1 protein modified form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[arsenic trioxide co-treated with PD 173074] results in decreased expression of RAF1 protein] |
CTD |
PMID:27794399 |
|
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
|
|
G |
Ramp1 |
receptor activity modifying protein 1 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of RAMP1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 9:91,765,481...91,816,152
Ensembl chr 9:91,781,285...91,816,151
|
|
G |
Rara |
retinoic acid receptor, alpha |
increases ubiquitination multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of RARA protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in decreased expression of RARA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased degradation of RARA protein] |
CTD |
PMID:20945414 PMID:24819975 |
|
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
|
|
G |
Rarres2 |
retinoic acid receptor responder 2 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of RARRES2 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of RARRES2 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556
|
|
G |
Rassf5 |
Ras association domain family member 5 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [RASSF5 protein results in decreased expression of CTNNB1 protein] |
CTD |
PMID:25217643 |
|
NCBI chr13:42,637,513...42,703,024
Ensembl chr13:42,637,549...42,703,024
|
|
G |
Rbl1 |
RB transcriptional corepressor like 1 |
increases expression increases ubiquitination multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of RBL1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of RBL1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [palbociclib results in decreased expression of RBL1 protein]; palbociclib promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of RBL1 protein] |
CTD |
PMID:20100483 |
|
NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
|
|
G |
Rbp3 |
retinol binding protein 3 |
decreases degradation |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of RBP3 protein mutant form |
CTD |
PMID:23486466 |
|
NCBI chr16:9,267,538...9,276,006
Ensembl chr16:9,267,538...9,276,006
|
|
G |
Rbpj |
recombination signal binding protein for immunoglobulin kappa J region |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of RBPJ protein [PSEN1 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the reaction [Cycloheximide results in decreased expression of RBPJ protein]; Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of RBPJ protein] |
CTD |
PMID:22302987 |
|
NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
|
|
G |
Rcn2 |
reticulocalbin 2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of RCN2 protein |
CTD |
PMID:21692457 |
|
NCBI chr 8:56,449,206...56,466,253
Ensembl chr 8:56,449,206...56,466,251
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
increases activity decreases expression increases ubiquitination multiple interactions affects localization decreases activity |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of RELA protein MG132 pretreatment decreases expression of protein in liver of intestinal ischemia/reperfusion rats benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of RELA protein Acetylcysteine inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [(+)-JQ1 compound affects the localization of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cisplatin promotes the reaction [RELA protein binds to TP63 protein alternative form]] which results in increased degradation of TP63 protein alternative form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [BRD4 mutant form affects the localization of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [CIGB-552 peptide results in decreased expression of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Deoxycholic Acid results in increased localization of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [EGF protein affects the localization of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [trimethyltin chloride affects the localization of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased activity of [NFKB1 protein binds to RELA protein]; SB 203580 inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of RELA protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the localization of RELA protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [halofuginone affects the localization of RELA protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zymosan affects the localization of RELA protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased activity of RELA protein |
CTD RGD |
PMID:11543732 PMID:12628480 PMID:12721113 PMID:14527959 PMID:14581482 PMID:15498850 PMID:16026644 PMID:16489207 PMID:17644113 PMID:18457675 PMID:21088498 PMID:22766066 PMID:23401744 PMID:23423712 PMID:23686307 PMID:22079846 More...
|
RGD:401794136 |
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Rgma |
repulsive guidance molecule BMP co-receptor a |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of RGMA mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918
|
|
G |
Rhob |
ras homolog family member B |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SMURF1 protein results in increased degradation of RHOB protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in decreased expression of RHOB protein] |
CTD |
PMID:30587574 PMID:31140275 |
|
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
|
|
G |
Rhoc |
ras homolog family member C |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [RNF168 protein results in decreased expression of RHOC protein] |
CTD |
PMID:34873829 |
|
NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306
|
|
G |
Rictor |
RPTOR independent companion of MTOR, complex 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of and results in increased ubiquitination of RICTOR protein |
CTD |
PMID:25897075 |
|
NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426
|
|
G |
Rnf144b |
ring finger protein 144B |
decreases degradation multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of RNF144B protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [2-hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1H-indole-5-carbonitrile inhibits the reaction [Estrogens deficiency results in decreased degradation of RNF144B protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [2-hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1H-indole-5-carbonitrile results in increased degradation of RNF144B protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lithium Chloride inhibits the reaction [Estrogens deficiency results in decreased degradation of RNF144B protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lithium Chloride results in increased degradation of RNF144B protein] |
CTD |
PMID:29724995 |
|
NCBI chr17:17,431,271...17,580,687
Ensembl chr17:17,432,786...17,562,760
|
|
G |
Rnf168 |
ring finger protein 168 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [RNF168 protein results in decreased expression of RHOC protein] |
CTD |
PMID:34873829 |
|
NCBI chr11:68,486,313...68,508,296
Ensembl chr11:68,486,321...68,508,277
|
|
G |
Rnf187 |
ring finger protein 187 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ro 31-8220 results in decreased stability of RNF187 protein] |
CTD |
PMID:25851810 |
|
NCBI chr10:43,709,493...43,715,392
Ensembl chr10:43,702,357...43,716,157
|
|
G |
Rnf208 |
ring finger protein 208 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of RNF208 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 3:8,057,808...8,059,721
Ensembl chr 3:8,043,685...8,059,844
|
|
G |
Rnf31 |
ring finger protein 31 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [RNF31 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 protein]] |
CTD |
PMID:34416243 |
|
NCBI chr15:29,083,047...29,095,328
Ensembl chr15:29,083,631...29,101,915
|
|
G |
Robo4 |
roundabout guidance receptor 4 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of ROBO4 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 8:37,119,953...37,133,887
Ensembl chr 8:37,119,988...37,132,519
|
|
G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
multiple interactions decreases phosphorylation |
EXP ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]; Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]] Sirolimus promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased phosphorylation of RPS6KB1 protein] |
CTD |
PMID:22689575 PMID:31645432 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
|
|
G |
Rptor |
regulatory associated protein of MTOR, complex 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of RPTOR protein |
CTD |
PMID:25897075 |
|
NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
|
|
G |
Rrm2 |
ribonucleotide reductase regulatory subunit M2 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of RRM2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
|
|
G |
RT1-Bb |
RT1 class II, locus Bb |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of H2-AB1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
|
|
G |
Rxra |
retinoid X receptor alpha |
multiple interactions increases expression |
ISO |
[alitretinoin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the localization of RXRA protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [alitretinoin results in increased degradation of RXRA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased degradation of RXRA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased stability of and results in increased expression of RXRA protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of RXRA protein |
CTD |
PMID:12970875 PMID:15707588 PMID:17170071 PMID:22310326 |
|
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
|
|
G |
Sae1 |
SUMO1 activating enzyme subunit 1 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SAE1 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986
|
|
G |
Scarb1 |
scavenger receptor class B, member 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein] |
CTD |
PMID:22442701 |
|
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
|
|
G |
Selenbp1 |
selenium binding protein 1 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SELENBP1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594
|
|
G |
Sesn2 |
sestrin 2 |
multiple interactions increases ubiquitination increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide results in decreased expression of SESN2 protein]; Lipopolysaccharides inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of SESN2 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SESN2 protein |
CTD |
PMID:25637945 |
|
NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
|
|
G |
Set |
Set nuclear proto-oncogene |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SET protein |
CTD |
PMID:21692457 |
|
NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567
|
|
G |
Sf1 |
splicing factor 1 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of SF1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 1:203,670,016...203,683,432
Ensembl chr 1:203,670,018...203,684,330
|
|
G |
Sh3kbp1 |
SH3 domain-containing kinase-binding protein 1 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SH3KBP1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr X:34,877,862...35,223,013
Ensembl chr X:34,877,866...35,222,747
|
|
G |
Siah2 |
siah E3 ubiquitin protein ligase 2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SIAH2 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950
|
|
G |
Sirt1 |
sirtuin 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] |
CTD |
PMID:25440059 |
|
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
|
|
G |
Sirt6 |
sirtuin 6 |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SIRT6 protein results in decreased expression of EP300 protein] |
CTD |
PMID:27094368 |
|
NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
|
|
G |
Skp1 |
S-phase kinase-associated protein 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SKP1 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388
|
|
G |
Skp2 |
S-phase kinase associated protein 2 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SKP2 mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SKP2 protein results in decreased expression of DUSP1 protein] |
CTD |
PMID:20061341 PMID:34697729 |
|
NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
|
|
G |
Slbp |
stem-loop histone mRNA binding protein |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in decreased expression of SLBP protein] |
CTD |
PMID:25266719 |
|
NCBI chr14:77,071,441...77,081,911
Ensembl chr14:77,071,632...77,081,906
|
|
G |
Slc10a2 |
solute carrier family 10 member 2 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SLC10A2 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resveratrol results in decreased expression of SLC10A2 protein] |
CTD |
PMID:23872411 PMID:24498857 |
|
NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475
|
|
G |
Slc11a2 |
solute carrier family 11 member 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [PRKN protein results in decreased expression of SLC11A2 protein alternative form] |
CTD |
PMID:20089134 |
|
NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
|
|
G |
Slc1a5 |
solute carrier family 1 member 5 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [lobetyolin results in decreased expression of SLC1A5 protein] |
CTD |
PMID:34075790 |
|
NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952
|
|
G |
Slc29a1 |
solute carrier family 29 member 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SLC29A1 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
|
|
G |
Slc2a1 |
solute carrier family 2 member 1 |
increases expression multiple interactions |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SLC2A1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [methylmercuric chloride results in decreased expression of SLC2A1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Methylmercury Compounds results in decreased expression of SLC2A1 protein] |
CTD |
PMID:17442736 PMID:31850806 PMID:32461003 |
|
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
|
|
G |
Slc31a1 |
solute carrier family 31 member 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein] |
CTD |
PMID:17108132 |
|
NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
|
|
G |
Slc39a4 |
solute carrier family 39 member 4 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein] |
CTD |
PMID:17202136 |
|
NCBI chr 7:108,333,368...108,337,553
Ensembl chr 7:108,333,381...108,337,553
|
|
G |
Slc6a3 |
solute carrier family 6 member 3 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [NDFIP1 protein results in decreased expression of SLC6A3 protein] |
CTD |
PMID:26300475 |
|
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
|
|
G |
Slc6a9 |
solute carrier family 6 member 9 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SLC6A9 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SLC6A9 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
|
|
G |
Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SLC7A11 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
|
|
G |
Sln |
sarcolipin |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SLN mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 8:54,221,389...54,248,110
Ensembl chr 8:54,243,542...54,247,791
|
|
G |
Smtnl2 |
smoothelin-like 2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SMTNL2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr10:57,008,322...57,029,505
Ensembl chr10:57,008,327...57,029,505
|
|
G |
Smurf1 |
SMAD specific E3 ubiquitin protein ligase 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SMURF1 protein results in increased degradation of RHOB protein] |
CTD |
PMID:30587574 |
|
NCBI chr12:9,635,009...9,726,520
Ensembl chr12:9,635,025...9,726,519
|
|
G |
Snca |
synuclein alpha |
increases phosphorylation multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of SNCA protein [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of and results in increased ubiquitination of NFE2L2 protein; baicalin inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased ubiquitination of NFE2L2 protein]; baicalin promotes the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein] |
CTD |
PMID:33157086 PMID:38016618 |
|
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
|
|
G |
Snrk |
SNF related kinase |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SNRK mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SNRK mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 8:121,779,704...121,833,949
Ensembl chr 8:121,793,302...121,832,323
|
|
G |
Soat2 |
sterol O-acyltransferase 2 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SOAT2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 7:133,281,818...133,294,915
Ensembl chr 7:133,281,818...133,294,915
|
|
G |
Socs3 |
suppressor of cytokine signaling 3 |
decreases degradation |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of SOCS3 protein |
CTD |
PMID:23782265 |
|
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions decreases expression increases expression |
ISO |
[sodium arsenite co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of SOD1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[SOD1 protein results in increased susceptibility to Thimerosal] which results in decreased expression of KCNIP3 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [BIRC2 protein results in increased degradation of SOD1 protein mutant form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [BIRC3 protein results in increased degradation of SOD1 protein mutant form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in decreased expression of SOD1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [sodium arsenite results in increased expression of SOD1 mRNA]; sodium arsenite inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SOD1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SOD1 mRNA |
CTD |
PMID:17309078 PMID:20061341 PMID:27773815 PMID:30503815 PMID:32301004 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
[SOD2 protein co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of HDAC2 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of SOD2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA]; CAT protein inhibits the reaction [[SOD2 protein co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased expression of HDAC2 protein] |
CTD |
PMID:12161520 PMID:24973648 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sort1 |
sortilin 1 |
multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tetrabromocinnamic acid results in increased degradation of SORT1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [wortmannin results in increased degradation of SORT1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SORT1 protein |
CTD |
PMID:25805502 |
|
NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
|
|
G |
Sox18 |
SRY-box transcription factor 18 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SOX18 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 3:168,785,488...168,787,290
Ensembl chr 3:168,785,490...168,787,290
|
|
G |
Sox9 |
SRY-box transcription factor 9 |
multiple interactions |
ISO |
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of SRY protein mutant form] which results in increased expression of SOX9 mRNA |
CTD |
PMID:27576690 |
|
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
|
|
G |
Sp1 |
Sp1 transcription factor |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [SP1 protein binds to ARNT promoter]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of and results in increased activity of SP1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of SP1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein] |
CTD |
PMID:14529614 PMID:17409431 PMID:34963561 |
|
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
|
|
G |
Sp3 |
Sp3 transcription factor |
multiple interactions increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SP3 protein |
CTD |
PMID:25068794 |
|
NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
|
|
G |
Spon2 |
spondin 2 |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SPON2 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr14:77,505,695...77,518,001
Ensembl chr14:77,511,901...77,517,996
|
|
G |
Spsb4 |
splA/ryanodine receptor domain and SOCS box containing 4 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SPSB4 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SPSB4 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 8:97,536,519...97,609,757
Ensembl chr 8:97,536,520...97,609,787
|
|
G |
Sqstm1 |
sequestosome 1 |
multiple interactions increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [ATG13 protein results in decreased expression of SQSTM1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [ATG7 protein results in decreased expression of SQSTM1 protein] [methylmercuric chloride co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of SQSTM1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [SQSTM1 protein affects the susceptibility to methylmercuric chloride]; methylmercuric chloride promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SQSTM1 mRNA] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SQSTM1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SQSTM1 protein |
CTD |
PMID:27629431 PMID:37258240 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
|
|
G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[arsenic trioxide co-treated with PD 173074] results in decreased expression of SRC protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SRC protein binds to NR1I3 protein] |
CTD |
PMID:24224465 PMID:27794399 |
|
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
|
|
G |
Srl |
sarcalumenin |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SRL mRNA |
CTD |
PMID:25566086 |
|
NCBI chr10:11,033,976...11,078,103
Ensembl chr10:11,034,035...11,078,101
|
|
G |
Srsf2 |
serine and arginine rich splicing factor 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [KAT5 protein results in increased acetylation of and results in increased degradation of SRSF2 protein] |
CTD |
PMID:21157427 |
|
NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
|
|
G |
Srxn1 |
sulfiredoxin 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SRXN1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
|
|
G |
Sry |
sex determining region Y |
decreases degradation increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of SRY protein mutant form benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SRY protein modified form [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of SRY protein mutant form] which results in increased expression of SOX9 mRNA; SRY protein mutant form promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SRY protein modified form] |
CTD |
PMID:27576690 |
|
NCBI chr Y:441,525...442,037
|
|
G |
Sspn |
sarcospan |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SSPN mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SSPN mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 4:178,890,030...178,946,267
Ensembl chr 4:178,897,147...178,931,554
|
|
G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tretinoin results in increased expression of and results in increased phosphorylation of STAT1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tretinoin results in increased expression of STAT1 mRNA] |
CTD |
PMID:20945414 |
|
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
|
|
G |
Stat6 |
signal transducer and activator of transcription 6 |
affects phosphorylation |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the phosphorylation of STAT6 protein |
CTD |
PMID:12459556 |
|
NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
|
|
G |
Stk11 |
serine/threonine kinase 11 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [STK11 mutant form results in increased expression of MYC protein]] |
CTD |
PMID:24793789 |
|
NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
|
|
G |
Strip2 |
striatin interacting protein 2 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of STRIP2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 4:58,536,034...58,578,279
Ensembl chr 4:58,536,055...58,578,291
|
|
G |
Sts |
steroid sulfatase |
multiple interactions decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IGF2 protein results in increased expression of STS protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased activity of STS protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of STS mRNA |
CTD |
PMID:16178010 PMID:24055520 |
|
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
|
|
G |
Suv39h1 |
SUV39H1 histone lysine methyltransferase |
multiple interactions |
ISO |
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[TNF protein co-treated with alpinetin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein]; [TNF protein co-treated with 6-formylindolo(3,2-b)carbazole co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein; [TNF protein co-treated with alpinetin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein; [TNF protein co-treated with Sirolimus co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein; AHR protein affects the reaction [[TNF protein co-treated with alpinetin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[TNF protein co-treated with alpinetin] results in decreased expression of SUV39H1 protein] |
CTD |
PMID:31676321 |
|
NCBI chr X:14,421,028...14,433,993
Ensembl chr X:14,421,109...14,433,982
|
|
G |
Suv39h1-ps1 |
SUV39H1 histone lysine methyltransferase, pseudogene 1 |
multiple interactions |
ISO |
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[TNF protein co-treated with alpinetin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein]; [TNF protein co-treated with 6-formylindolo(3,2-b)carbazole co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein; [TNF protein co-treated with alpinetin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein; [TNF protein co-treated with Sirolimus co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein; AHR protein affects the reaction [[TNF protein co-treated with alpinetin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[TNF protein co-treated with alpinetin] results in decreased expression of SUV39H1 protein] |
CTD |
PMID:31676321 |
|
NCBI chr X:141,792,589...141,795,257
|
|
G |
Swt1 |
SWT1 RNA endoribonuclease homolog |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of SWT1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr13:63,452,494...63,509,982
Ensembl chr13:63,452,496...63,509,980
|
|
G |
Sybu |
syntabulin |
multiple interactions increases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SYBU mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 7:75,847,000...75,948,919
Ensembl chr 7:75,847,003...75,948,828
|
|
G |
Synpo |
synaptopodin |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of SYNPO mRNA |
CTD |
PMID:25566086 |
|
NCBI chr18:54,048,299...54,106,388
Ensembl chr18:54,026,152...54,102,126
|
|
G |
Syp |
synaptophysin |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [AGT protein results in increased degradation of SYP protein] |
CTD |
PMID:18487452 |
|
NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745
|
|
G |
Taf1 |
TATA-box binding protein associated factor 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of TAF1 protein] |
CTD |
PMID:17409431 |
|
NCBI chr X:66,640,915...66,716,543
Ensembl chr X:66,640,982...66,716,543
|
|
G |
Taf1a |
TATA-box binding protein associated factor, RNA polymerase I subunit A |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TAF1A mRNA |
CTD |
PMID:25566086 |
|
NCBI chr13:95,012,160...95,048,131
Ensembl chr13:95,029,225...95,048,087
|
|
G |
Tardbp |
TAR DNA binding protein |
affects localization increases ubiquitination |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the localization of TARDBP protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of TARDBP protein |
CTD |
PMID:19765185 PMID:31780563 |
|
NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
|
|
G |
Tdrp |
testis development related protein |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TDRP mRNA |
CTD |
PMID:25566086 |
|
NCBI chr16:75,624,047...75,652,635
Ensembl chr16:75,624,907...75,652,420
|
|
G |
Tenm4 |
teneurin transmembrane protein 4 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TENM4 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TENM4 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 1:149,895,097...151,263,315
Ensembl chr 1:150,780,381...151,259,144
|
|
G |
Tert |
telomerase reverse transcriptase |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [APP protein modified form results in decreased expression of and results in decreased activity of TERT protein] |
CTD |
PMID:21520056 |
|
NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
|
|
G |
Tesc |
tescalcin |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TESC mRNA |
CTD |
PMID:25566086 |
|
NCBI chr12:38,521,832...38,555,665
Ensembl chr12:38,521,861...38,555,824
|
|
G |
Tfam |
transcription factor A, mitochondrial |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [troglitazone results in decreased expression of TFAM mRNA] |
CTD |
PMID:20860658 |
|
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
|
|
G |
Tfrc |
transferrin receptor |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TFRC mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TFRC mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
|
|
G |
Tg |
thyroglobulin |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Amiodarone results in decreased expression of TG protein] |
CTD |
PMID:25295624 |
|
NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TGFB1 protein results in decreased expression of LPIN1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TH5487 inhibits the reaction [TGFB1 protein results in increased expression of OGG1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [TGFB1 protein results in increased expression of OGG1 protein] |
CTD |
PMID:27345520 PMID:35654123 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tgfbi |
transforming growth factor, beta induced |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TGFBI mRNA |
CTD |
PMID:25566086 |
|
NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240
|
|
G |
Tgfbr1 |
transforming growth factor, beta receptor 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tolfenamic acid results in decreased expression of TGFBR1 protein] |
CTD |
PMID:31381904 |
|
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
|
|
G |
Thy1 |
Thy-1 cell surface antigen |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of THY1 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of THY1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
|
|
G |
Tiparp |
TCDD-inducible poly(ADP-ribose) polymerase |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] |
CTD |
PMID:12147270 |
|
NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
|
|
G |
Tk1 |
thymidine kinase 1 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TK1 mRNA [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of TK1 mRNA |
CTD |
PMID:20061341 PMID:25566086 |
|
NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
|
|
G |
Tmem176a |
transmembrane protein 176A |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of TMEM176A mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 4:77,774,940...77,778,620
Ensembl chr 4:77,774,843...77,778,620
|
|
G |
Tmem176b |
transmembrane protein 176B |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of TMEM176B mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 4:77,766,928...77,774,740
Ensembl chr 4:77,766,928...77,774,384
|
|
G |
Tmem204 |
transmembrane protein 204 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TMEM204 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TMEM204 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr10:14,076,518...14,104,849
Ensembl chr10:14,076,519...14,101,920
|
|
G |
Tmod1 |
tropomodulin 1 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TMOD1 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TMOD1 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 5:60,316,445...60,393,957
Ensembl chr 5:60,338,512...60,393,956
|
|
G |
Tmt1a |
thiol methyltransferase 1A |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TMT1A mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions decreases expression |
ISO EXP |
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[TNF protein co-treated with alpinetin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with TNF protein] results in increased phosphorylation of NFKBIA protein; [TNF protein co-treated with 6-formylindolo(3,2-b)carbazole co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein; [TNF protein co-treated with alpinetin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein; [TNF protein co-treated with Sirolimus co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein; AHR protein affects the reaction [[TNF protein co-treated with alpinetin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[TNF protein co-treated with alpinetin] results in decreased expression of SUV39H1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [hydroquinone results in increased expression of TNF protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CX3CL1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CXCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased secretion of PTGS2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased secretion of VEGFA protein]; TNF protein affects the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Thiopental] affects the phosphorylation of NFKBIA protein] MG132 pretreatment decreases expression of TNFa, IL6 protein in serum of intestinal ischemia/reperfusion rats benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TNF mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]] benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zymosan results in increased expression of TNF mRNA] |
CTD RGD |
PMID:11230753 PMID:11698246 PMID:12185005 PMID:12628480 PMID:12883408 PMID:14572618 PMID:19393675 PMID:23288922 PMID:23395999 PMID:24085292 PMID:24613819 PMID:28134560 PMID:31676321 PMID:31806706 PMID:22079846 More...
|
RGD:401794136 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tnfaip1 |
TNF alpha induced protein 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNFAIP1 protein results in increased degradation of CSNK2B protein] |
CTD |
PMID:37302538 |
|
NCBI chr10:63,417,774...63,432,466
Ensembl chr10:63,417,775...63,432,466
|
|
G |
Tnfaip3 |
TNF alpha induced protein 3 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [RNF31 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 protein]] |
CTD |
PMID:34416243 |
|
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
|
|
G |
Tnfaip8l1 |
TNF alpha induced protein 8 like 1 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TNFAIP8L1 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 9:988,587...999,342
Ensembl chr 9:988,594...1,002,254
|
|
G |
Tnfrsf10b |
TNF receptor superfamily member 10b |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TNFRSF10A protein |
CTD |
PMID:16287099 |
|
NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
|
|
G |
Tnni1 |
troponin I1, slow skeletal type |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TNNI1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr13:47,229,217...47,241,640
Ensembl chr13:47,229,216...47,241,644
|
|
G |
Tnni2 |
troponin I2, fast skeletal type |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TNNI2 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TNNI2 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 1:197,595,012...197,597,554
Ensembl chr 1:197,594,813...197,597,560
|
|
G |
Tnni3 |
troponin I3, cardiac type |
multiple interactions decreases expression |
EXP ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in decreased expression of TNNI3 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TNNI3 mRNA |
CTD |
PMID:19801490 PMID:25566086 |
|
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
|
|
G |
Top2a |
DNA topoisomerase II alpha |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]] |
CTD |
PMID:17575151 |
|
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression increases ubiquitination |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Zinc Sulfate co-treated with prolinedithiocarbamate] results in decreased expression of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Capsaicin results in increased degradation of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Chlorpyrifos results in decreased expression of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of TP53 protein mutant form]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of TP53 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TP53 protein modified form benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of TP53 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Acetaminophen results in increased degradation of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of and results in increased expression of TP53 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TP53 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TP53 protein |
CTD |
PMID:10837373 PMID:16330492 PMID:18463101 PMID:18951928 PMID:19699254 PMID:20530418 PMID:21454520 PMID:26612707 PMID:27129209 PMID:27993609 PMID:31806706 PMID:35821281 More...
|
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Tp63 |
tumor protein p63 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cisplatin promotes the reaction [RELA protein binds to TP63 protein alternative form]] which results in increased degradation of TP63 protein alternative form] |
CTD |
PMID:21088498 |
|
NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
|
|
G |
Traf2 |
Tnf receptor-associated factor 2 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TRAF2 protein results in decreased expression of KLF2 protein] |
CTD |
PMID:35635602 |
|
NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
|
|
G |
Trib2 |
tribbles pseudokinase 2 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of TRIB2 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 6:38,545,971...38,570,349
Ensembl chr 6:38,545,975...38,569,370
|
|
G |
Trib3 |
tribbles pseudokinase 3 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TRIB3 mRNA |
CTD |
PMID:31806706 |
|
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
|
|
G |
Tril |
TLR4 interactor with leucine-rich repeats |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TRIL mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TRIL mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 4:82,922,327...82,927,172
Ensembl chr 4:82,922,328...82,927,172
|
|
G |
Trim72 |
tripartite motif containing 72 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TRIM72 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 1:182,613,753...182,621,613
Ensembl chr 1:182,613,712...182,621,606
|
|
G |
Tsc22d3 |
TSC22 domain family, member 3 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]] |
CTD |
PMID:20671745 |
|
NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861
|
|
G |
Tsc22d4 |
TSC22 domain family, member 4 |
decreases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TSC22D4 mRNA MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of TSC22D4 mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr12:18,939,150...18,952,008
Ensembl chr12:18,914,398...18,952,008
|
|
G |
Txnl1 |
thioredoxin-like 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [arsenite results in increased degradation of TXNL1 protein] |
CTD |
PMID:19349280 |
|
NCBI chr18:57,125,362...57,155,167
Ensembl chr18:57,125,369...57,165,266
|
|
G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TXNRD1 mRNA |
CTD |
PMID:18550526 |
|
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
|
|
G |
Tymp |
thymidine phosphorylase |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMP protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]] |
CTD |
PMID:21444628 PMID:30796972 |
|
NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874 Ensembl chr 7:120,438,770...120,443,874
|
|
G |
Tyms |
thymidylate synthetase |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [cinobufagin results in decreased expression of TYMS protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [trichostatin A results in decreased expression of TYMS protein] |
CTD |
PMID:17172411 PMID:21444628 PMID:35427566 |
|
NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
|
|
G |
Tyr |
tyrosinase |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Fenofibrate results in decreased expression of TYR protein] |
CTD |
PMID:23872139 |
|
NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
|
|
G |
Ubb |
ubiquitin B |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[PARK protein co-treated with UBB protein] results in decreased expression of FIS1 protein] |
CTD |
PMID:20164189 |
|
NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,245,637...47,249,333
|
|
G |
Ubc |
ubiquitin C |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of UBC mRNA HSF1 promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of UBC mRNA] |
CTD |
PMID:30186748 |
|
NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925
|
|
G |
Ube2c |
ubiquitin-conjugating enzyme E2C |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of UBE2C mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
|
|
G |
Ube2t |
ubiquitin-conjugating enzyme E2T |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of UBE2T mRNA |
CTD |
PMID:20061341 |
|
NCBI chr13:46,403,352...46,413,854
Ensembl chr13:46,403,375...46,414,835
|
|
G |
Ubqln1 |
ubiquilin 1 |
increases stability |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased stability of UBQLN1 protein mutant form |
CTD |
PMID:24747970 |
|
NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090
|
|
G |
Ubr1 |
ubiquitin protein ligase E3 component n-recognin 1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of UBR1 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr 3:107,813,721...107,921,701
Ensembl chr 3:107,811,392...107,922,204
|
|
G |
Ubxn1 |
UBX domain protein 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NGLY1 protein binds to UBXN1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein] |
CTD |
PMID:15362974 |
|
NCBI chr 1:205,765,309...205,769,234
Ensembl chr 1:205,745,120...205,816,520
|
|
G |
Uchl1 |
ubiquitin C-terminal hydrolase L1 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of UCHL1 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590
|
|
G |
Ufd1 |
ubiquitin recognition factor in ER associated degradation 1 |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of UFD1 mRNA [MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of UFD1 mRNA |
CTD |
PMID:20061341 PMID:25566086 |
|
NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087
|
|
G |
Uhrf1 |
ubiquitin-like with PHD and ring finger domains 1 |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of UHRF1 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
|
|
G |
Ulk1 |
unc-51 like autophagy activating kinase 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein] |
CTD |
PMID:27629431 |
|
NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
|
|
G |
Unc13c |
unc-13 homolog C |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of UNC13C mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 8:74,247,026...74,697,629
Ensembl chr 8:74,247,899...74,673,223
|
|
G |
Usp14 |
ubiquitin specific peptidase 14 |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of USP14 mRNA |
CTD |
PMID:20061341 |
|
NCBI chr18:1,018,111...1,057,727
Ensembl chr18:1,019,400...1,057,519
|
|
G |
Usp15 |
ubiquitin specific peptidase 15 |
multiple interactions |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [NFE2L2 protein inhibits the reaction [Streptozocin results in increased expression of USP15 protein]] |
CTD |
PMID:35478295 |
|
NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721
|
|
G |
Usp28 |
ubiquitin specific peptidase 28 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [nickel sulfate results in decreased expression of USP28 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen deficiency results in decreased expression of USP28 protein] |
CTD |
PMID:20046830 |
|
NCBI chr 8:49,325,766...49,386,229
Ensembl chr 8:49,325,867...49,386,229
|
|
G |
Usp7 |
ubiquitin specific peptidase 7 |
multiple interactions |
ISO |
[USP7 protein co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HMOX1 protein; [USP7 protein mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HMOX1 protein; Arsenic inhibits the reaction [[USP7 protein mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HMOX1 protein]; Arsenic promotes the reaction [[USP7 protein co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of HMOX1 protein]; Arsenic promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HMOX1 protein binds to USP7 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Sirolimus inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [USP7 protein affects the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HMOX1 protein binds to USP7 protein]; USP7 protein affects the reaction [Arsenic inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of HMOX1 protein]]; USP7 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of HMOX1 protein] |
CTD |
PMID:32802178 PMID:35821281 |
|
NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355
|
|
G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of VCAM1 mRNA |
CTD |
PMID:11698246 PMID:18457675 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
|
|
G |
Vcp |
valosin-containing protein |
increases expression multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of VCP protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein] |
CTD |
PMID:15362974 |
|
NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions increases expression |
EXP ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [methylmercuric chloride results in decreased expression of VEGFA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Methylmercury Compounds results in decreased expression of VEGFA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of VEGFA mRNA] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of VEGFA protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of VEGFA mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased secretion of VEGFA protein] |
CTD |
PMID:12590138 PMID:24613819 PMID:28651835 PMID:31850806 PMID:32461003 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
G |
Vhl |
von Hippel-Lindau tumor suppressor |
multiple interactions |
ISO |
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HIF1A protein binds to VHL protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [VHL protein binds to HIF1A protein]; manganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]]; Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HIF1A protein binds to VHL protein]] |
CTD |
PMID:17973296 PMID:19263519 |
|
NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
|
|
G |
Vim |
vimentin |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [AHR protein results in decreased expression of VIM protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [AHR protein binds to VIM protein] |
CTD |
PMID:27752740 |
|
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
|
|
G |
Vwf |
von Willebrand factor |
decreases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of VWF mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
|
|
G |
Wwtr1 |
WW domain containing transcription regulator 1 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of WWTR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tcdA protein, Clostridium difficile results in decreased expression of WWTR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [toxB protein, Clostridium difficile results in decreased expression of WWTR1 protein] |
CTD |
PMID:33251692 PMID:33539684 |
|
NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968
|
|
G |
Xbp1 |
X-box binding protein 1 |
decreases response to substance increases expression multiple interactions |
ISO |
XBP1 protein results in decreased susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of XBP1 protein alternative form 4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of XBP1 protein alternative form]; [XBP1 mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of EIF2S1 protein]; [XBP1 mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein] |
CTD |
PMID:19135031 PMID:25568320 PMID:27638906 |
|
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
|
|
G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions increases ubiquitination increases cleavage |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of XIAP protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cannabidiol promotes the reaction [DIABLO protein binds to XIAP protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cannabidiol results in decreased expression of XIAP protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [diallyl trisulfide results in decreased expression of XIAP protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in decreased expression of XIAP protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cannabidiol results in increased ubiquitination of XIAP protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [trimethyltin chloride results in decreased expression of XIAP protein]; Cannabidiol promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of XIAP protein] benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of XIAP protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Topotecan results in increased degradation of XIAP protein] |
CTD |
PMID:16287099 PMID:19812371 PMID:21411500 PMID:22627131 PMID:23423712 PMID:31699976 More...
|
|
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
|
|
G |
Xpc |
XPC complex subunit, DNA damage recognition and repair factor |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in decreased expression of XPC protein] |
CTD |
PMID:28237621 |
|
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
|
|
G |
Yap1 |
Yes1 associated transcriptional regulator |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tcdA protein, Clostridium difficile results in decreased expression of YAP1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [toxB protein, Clostridium difficile results in decreased expression of YAP1 protein] |
CTD |
PMID:33251692 |
|
NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
|
|
G |
Zbtb8b |
zinc finger and BTB domain containing 8b |
multiple interactions decreases expression |
ISO |
MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ZBTB8B mRNA] |
CTD |
PMID:25566086 |
|
NCBI chr 5:141,765,925...141,781,619
Ensembl chr 5:141,766,309...141,781,600
|
|
G |
Zfand2a |
zinc finger AN1-type containing 2A |
increases expression |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ZFAND2A mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ZFAND2A protein |
CTD |
PMID:24619424 PMID:25566086 PMID:31540997 |
|
NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677
|
|
G |
Zfp36 |
zinc finger protein 36 |
multiple interactions |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [hydroquinone results in decreased expression of ZFP36 protein] |
CTD |
PMID:23288922 |
|
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
|
|
G |
Zfyve21 |
zinc finger FYVE-type containing 21 |
multiple interactions |
ISO |
[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of ZFYVE21 mRNA |
CTD |
PMID:25566086 |
|
NCBI chr 6:130,873,979...130,894,618
Ensembl chr 6:130,873,912...130,894,411
|
|
|
G |
Ada |
adenosine deaminase |
multiple interactions |
ISO |
ADA protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides] |
CTD |
PMID:10947063 |
|
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation increases activity multiple interactions |
ISO EXP |
N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein N-Formylmethionine Leucyl-Phenylalanine results in increased activity of AKT1 protein 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [AKT1 protein binds to NCF1 protein]]; 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of AKT1 protein]; N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [AKT1 protein binds to NCF1 protein] cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:15925284 PMID:16621998 PMID:19445920 PMID:34144024 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions |
ISO |
[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]; ALOX5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of ALOX5 protein; SB 203580 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of ALOX5 protein] |
CTD |
PMID:9495842 PMID:10779545 PMID:11116075 |
|
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
|
|
G |
Arf1 |
ARF GTPase 1 |
affects localization |
ISO |
N-Formylmethionine Leucyl-Phenylalanine affects the localization of ARF1 protein |
CTD |
PMID:10931844 |
|
NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434
|
|
G |
Arf6 |
ARF GTPase 6 |
multiple interactions affects localization |
ISO |
1-Butanol inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 1-Butanol inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]; ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides] N-Formylmethionine Leucyl-Phenylalanine affects the localization of ARF6 protein |
CTD |
PMID:10931844 |
|
NCBI chr 6:87,853,742...87,854,890
Ensembl chr 6:87,840,142...87,874,114
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases activity |
ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased activity of BAX protein |
CTD |
PMID:20130848 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP3 protein] |
CTD |
PMID:20130848 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
multiple interactions increases activity |
ISO |
Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP9 protein] |
CTD |
PMID:20130848 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cd38 |
CD38 molecule |
increases cleavage multiple interactions |
ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased cleavage of CD38 protein SB 203580 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased cleavage of CD38 protein] |
CTD |
PMID:15494208 |
|
NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
|
|
G |
Cd63 |
Cd63 molecule |
multiple interactions increases expression |
ISO |
Mustard Gas promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]; Quercetin affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]; SB 203580 inhibits the reaction [Mustard Gas promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]] |
CTD |
PMID:19887118 PMID:22036725 |
|
NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
|
|
G |
Ctsg |
cathepsin G |
multiple interactions increases secretion |
ISO |
cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of CTSG protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of CTSG protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of CTSG protein] |
CTD |
PMID:25980585 PMID:34144024 |
|
NCBI chr15:29,930,988...29,937,353
Ensembl chr15:29,931,003...29,937,353
|
|
G |
Cyba |
cytochrome b-245 alpha chain |
multiple interactions |
EXP |
2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of NCF1 protein] promotes the reaction [NCF1 protein binds to CYBA protein]]; [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of NCF1 protein] promotes the reaction [NCF1 protein binds to CYBA protein] |
CTD |
PMID:19445920 |
|
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
|
|
G |
Cybb |
cytochrome b-245 beta chain |
increases activity multiple interactions |
ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CYBB protein diphenyleneiodonium inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CYBB protein]; Genistein inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CYBB protein] |
CTD |
PMID:29183754 |
|
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
|
|
G |
Elane |
elastase, neutrophil expressed |
multiple interactions increases secretion |
ISO |
2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of ELANE protein]; [Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein; pirinixic acid analog inhibits the reaction [[Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein] |
CTD |
PMID:19686721 PMID:21457779 |
|
NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
|
|
G |
Enpp3 |
ectonucleotide pyrophosphatase/phosphodiesterase 3 |
multiple interactions increases expression |
ISO |
Quercetin affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ENPP3 protein] |
CTD |
PMID:19887118 |
|
NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041
|
|
G |
Fgr |
FGR proto-oncogene, Src family tyrosine kinase |
multiple interactions increases phosphorylation |
ISO |
1-Butanol inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with dihydrocytochalasin B] results in increased activity of FGR protein] N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of FGR protein |
CTD |
PMID:11078731 PMID:25980585 |
|
NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
|
|
G |
Fpr1 |
formyl peptide receptor 1 |
multiple interactions |
ISO |
N-Formylmethionine Leucyl-Phenylalanine binds to and results in increased activity of FPR1 protein |
CTD |
PMID:17520823 |
|
NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:58,747,246...58,756,559
|
|
G |
Gusb |
glucuronidase, beta |
increases secretion multiple interactions |
EXP ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of GUSB protein epigallocatechin gallate inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of GUSB protein] |
CTD |
PMID:9545557 PMID:11944907 |
|
NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
|
|
G |
Hck |
HCK proto-oncogene, Src family tyrosine kinase |
increases phosphorylation |
ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of HCK protein |
CTD |
PMID:25980585 |
|
NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of IL1B protein]; nimesulide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of IL1B protein] |
CTD |
PMID:12946449 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il3 |
interleukin 3 |
increases response to substance |
ISO |
IL3 protein results in increased susceptibility to N-Formylmethionine Leucyl-Phenylalanine |
CTD |
PMID:11145705 |
|
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
|
|
G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
ISO |
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of IL6 protein]; nimesulide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of IL6 protein] |
CTD |
PMID:12946449 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Itga2b |
integrin subunit alpha 2b |
multiple interactions |
ISO |
ITGA2B protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein] |
CTD |
PMID:11116075 |
|
NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
|
|
G |
Itgam |
integrin subunit alpha M |
multiple interactions increases expression |
ISO |
2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; dimemorfan inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; Foropafant inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; KT 5720 inhibits the reaction [2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Rolipram inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; plaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; Rolipram inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; Staurosporine inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein] fMLP increases expression of ITGAM protein on neutrophils and monocytes [N-formyl-methionyl-leucyl-phenylalanine cotreated with midazolam] decreases expression of ITGAM protein on neutrophils |
CTD RGD |
PMID:10215738 PMID:11116075 PMID:15774851 PMID:18500357 PMID:21457779 PMID:18064325 PMID:20421794 More...
|
RGD:329901666, RGD:329853762 |
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
|
|
G |
Itgb2 |
integrin subunit beta 2 |
increases expression multiple interactions |
ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; crenatoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; plaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein] |
CTD |
PMID:10215738 PMID:16393473 PMID:21664406 |
|
NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
|
|
G |
Itgb3 |
integrin subunit beta 3 |
increases expression |
ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB3 protein |
CTD |
PMID:21664406 |
|
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
|
|
G |
Lyn |
LYN proto-oncogene, Src family tyrosine kinase |
multiple interactions increases phosphorylation |
ISO |
AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein] |
CTD |
PMID:25980585 |
|
NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
|
|
G |
Lyz2 |
lysozyme 2 |
increases secretion |
EXP |
N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of LYZ protein |
CTD |
PMID:9545557 |
|
NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO EXP |
cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; Grape Seed Proanthocyanidins inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Pentoxifylline inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Qingdai compound inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein] N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein; resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein] RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:11145705 PMID:11427526 PMID:15494208 PMID:16212921 PMID:16621998 PMID:17377739 PMID:17560994 PMID:19167369 PMID:19559779 PMID:19697996 PMID:25980585 PMID:34144024 More...
|
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions increases phosphorylation |
ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK14 protein; Omeprazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:16621998 PMID:17406807 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO EXP |
cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; Grape Seed Proanthocyanidins inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Pentoxifylline inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Qingdai compound inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; Resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein] N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein; resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein] RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:11145705 PMID:11427526 PMID:15494208 PMID:16212921 PMID:16621998 PMID:17377739 PMID:17560994 PMID:19167369 PMID:19559779 PMID:19697996 PMID:25980585 PMID:34144024 More...
|
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO EXP |
N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK8 protein; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK8 protein] MAPK8 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Reactive Oxygen Species]; N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK8 protein |
CTD |
PMID:17377739 PMID:17560994 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mmp8 |
matrix metallopeptidase 8 |
increases expression |
ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased expression of MMP8 protein |
CTD |
PMID:32367270 |
|
NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions increases activity increases secretion increases expression |
ISO |
carvedilol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of MPO protein] N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein carvedilol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein]; diphenyleneiodonium inhibits the reaction [manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]]; manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]; Sodium Azide inhibits the reaction [manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]]; wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein] |
CTD |
PMID:16601795 PMID:17159805 PMID:18987595 PMID:22906169 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Ncf1 |
neutrophil cytosolic factor 1 |
multiple interactions affects localization increases phosphorylation |
ISO EXP |
AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF1 protein]; bisindolylmaleimide I inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF1 protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF1 protein] N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of NCF1 protein 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of NCF1 protein] promotes the reaction [NCF1 protein binds to CYBA protein]]; 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF1 protein]; 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [AKT1 protein binds to NCF1 protein]]; 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [NCF1 protein binds to PAK1 protein]]; 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of NCF1 protein]; [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of NCF1 protein] promotes the reaction [NCF1 protein binds to CYBA protein]; N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [AKT1 protein binds to NCF1 protein]; N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [NCF1 protein binds to PAK1 protein] |
CTD |
PMID:19445920 PMID:25980585 |
|
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
|
|
G |
Ncf2 |
neutrophil cytosolic factor 2 |
affects localization multiple interactions |
EXP |
N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF2 protein 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF2 protein] |
CTD |
PMID:19445920 |
|
NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277
|
|
G |
Ncf4 |
neutrophil cytosolic factor 4 |
affects localization multiple interactions |
EXP |
N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF4 protein 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF4 protein] |
CTD |
PMID:19445920 |
|
NCBI chr 7:109,825,420...109,843,389
Ensembl chr 7:109,826,020...109,843,389
|
|
G |
Pak1 |
p21 (RAC1) activated kinase 1 |
multiple interactions |
EXP |
2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PAK1 protein]; 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [NCF1 protein binds to PAK1 protein]]; N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased activity of PAK1 protein; N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [NCF1 protein binds to PAK1 protein] |
CTD |
PMID:19445920 |
|
NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
|
|
G |
Pak2 |
p21 (RAC1) activated kinase 2 |
multiple interactions increases phosphorylation |
EXP |
2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of PAK2 protein] |
CTD |
PMID:19445920 |
|
NCBI chr11:68,707,940...68,768,816
Ensembl chr11:68,707,969...68,768,816
|
|
G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
increases expression |
ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased expression of PECAM1 protein |
CTD |
PMID:21664406 |
|
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
|
|
G |
Pla2g4a |
phospholipase A2 group 4A |
multiple interactions |
ISO |
PLA2G4A protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased metabolism of Leukotriene B4] |
CTD |
PMID:11741884 |
|
NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
|
|
G |
Pla2g5 |
phospholipase A2, group V |
increases activity multiple interactions increases secretion |
ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased activity of PLA2G5 protein PLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Arachidonic Acid]; PLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4] N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of PLA2G5 protein |
CTD |
PMID:9495842 PMID:11741884 |
|
NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
|
|
G |
Plcg2 |
phospholipase C, gamma 2 |
multiple interactions increases phosphorylation |
ISO |
AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of PLCG2 protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of PLCG2 protein] |
CTD |
PMID:25980585 |
|
NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
|
|
G |
Pld1 |
phospholipase D1 |
multiple interactions |
ISO EXP |
PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein] PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Reactive Oxygen Species] |
CTD |
PMID:11427526 PMID:17560994 |
|
NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
|
|
G |
Prkca |
protein kinase C, alpha |
multiple interactions |
EXP |
2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCA protein]; N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCA protein |
CTD |
PMID:19445920 |
|
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
|
|
G |
Prkcb |
protein kinase C, beta |
multiple interactions |
EXP |
2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCB protein]; N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCB protein |
CTD |
PMID:19445920 |
|
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
|
|
G |
Prkcd |
protein kinase C, delta |
multiple interactions |
EXP |
2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCD protein]; N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCD protein |
CTD |
PMID:19445920 |
|
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
|
|
G |
Prkcz |
protein kinase C, zeta |
multiple interactions |
EXP |
2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCZ protein]; N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCZ protein |
CTD |
PMID:19445920 |
|
NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
|
|
G |
Ptafr |
platelet-activating factor receptor |
multiple interactions |
ISO |
PTAFR protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein] |
CTD |
PMID:11116075 |
|
NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression |
ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased expression of PTGS2 mRNA; N-Formylmethionine Leucyl-Phenylalanine results in increased expression of PTGS2 protein |
CTD |
PMID:12946449 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rac1 |
Rac family small GTPase 1 |
increases activity multiple interactions |
ISO EXP |
N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein] 6-amino-N-(3-(4-(4-morpholinyl)pyrido(3',2'-4,5)furo(3,2-d)pyrimidin-2-yl)phenyl)-3-pyridinecarboxamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein]; apilimod inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein]; RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein] |
CTD |
PMID:16621998 PMID:19445920 PMID:28779020 |
|
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
|
|
G |
Rac2 |
Rac family small GTPase 2 |
increases activity decreases activity multiple interactions |
ISO EXP |
N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein N-Formylmethionine Leucyl-Phenylalanine results in decreased activity of RAC2 protein 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in decreased activity of RAC2 protein] 6-amino-N-(3-(4-(4-morpholinyl)pyrido(3',2'-4,5)furo(3,2-d)pyrimidin-2-yl)phenyl)-3-pyridinecarboxamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]; apilimod inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]; RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein] |
CTD |
PMID:11145705 PMID:16621998 PMID:19445920 PMID:28779020 |
|
NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720
|
|
G |
Rhog |
ras homolog family member G |
multiple interactions affects response to substance |
ISO |
RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein]; RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein] RHOG protein affects the susceptibility to N-Formylmethionine Leucyl-Phenylalanine |
CTD |
PMID:16621998 |
|
NCBI chr 1:156,618,713...156,630,710
Ensembl chr 1:156,615,349...156,631,257
|
|
G |
Sell |
selectin L |
increases expression |
ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELL protein |
CTD |
PMID:21664406 |
|
NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
|
|
G |
Selp |
selectin P |
multiple interactions increases expression |
ISO |
ALOX5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; Foropafant inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; ITGA2B protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; MK-886 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; PTAFR protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; SR 121566 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; zileuton inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein] |
CTD |
PMID:11116075 |
|
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
|
|
G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
increases phosphorylation multiple interactions |
ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein]; cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein] |
CTD |
PMID:25980585 PMID:34144024 |
|
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
|
|
G |
Tec |
tec protein tyrosine kinase |
multiple interactions affects localization |
ISO |
AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of TEC protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of TEC protein] |
CTD |
PMID:25980585 |
|
NCBI chr14:35,352,551...35,461,585
Ensembl chr14:35,352,829...35,461,557
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
ISO |
[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides; Cyclosporine inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]; Tacrolimus inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides] N-Formylmethionine Leucyl-Phenylalanine results in increased expression of TNF protein |
CTD |
PMID:11121130 PMID:12946449 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tnfaip6 |
TNF alpha induced protein 6 |
decreases response to substance |
ISO |
TNFAIP6 protein modified form results in decreased susceptibility to N-Formylmethionine Leucyl-Phenylalanine |
CTD |
PMID:12401803 |
|
NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
|
|
G |
Vav1 |
vav guanine nucleotide exchange factor 1 |
increases phosphorylation |
ISO |
N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of VAV1 protein |
CTD |
PMID:25980585 |
|
NCBI chr 9:2,161,985...2,209,951
Ensembl chr 9:2,157,900...2,208,937
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions increases expression increases secretion |
ISO |
Masoprocol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA mRNA]; Masoprocol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of VEGFA protein]; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA mRNA]; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of VEGFA protein] N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA mRNA; N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA protein |
CTD |
PMID:17377739 PMID:17459229 PMID:17520823 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
|
G |
Birc3 |
baculoviral IAP repeat-containing 3 |
increases expression |
ISO |
Pam3Cys increases expression of BIRC3 mRNA in colorectal cancer cells |
RGD |
PMID:29689497 |
RGD:152999011 |
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
|
|
G |
Irak3 |
interleukin-1 receptor-associated kinase 3 |
increases expression |
ISO |
N-palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-Cys-Ser-Lys-Lys-Lys-Lys increases expression of Irak3 mRNA and protein in splenocyte Pam3CSK4 increases expression of Irak3 mRNA and protein in peritoneal macrophages |
RGD |
PMID:28954388 PMID:21998452 |
RGD:34888230, RGD:36049794 |
NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
|
|
|
G |
Tas1r2 |
taste 1 receptor member 2 |
affects binding multiple interactions |
ISO |
neotame binds to [TAS1R2 protein binds to TAS1R3 protein]; neotame binds to TAS1R2 protein neotame binds to and results in increased activity of TAS1R2 protein; neotame results in increased activity of [TAS1R2 protein binds to TAS1R3 protein] |
CTD |
PMID:15353592 PMID:17168764 PMID:20173092 |
|
NCBI chr 5:151,909,617...151,925,760
Ensembl chr 5:151,830,701...151,925,345
|
|
G |
Tas1r3 |
taste 1 receptor member 3 |
affects binding multiple interactions |
ISO |
neotame binds to [TAS1R2 protein binds to TAS1R3 protein] neotame results in increased activity of [TAS1R2 protein binds to TAS1R3 protein] |
CTD |
PMID:17168764 PMID:20173092 |
|
NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742
|
|
|
G |
Ace |
angiotensin I converting enzyme |
decreases activity |
ISO |
omapatrilat results in decreased activity of ACE protein |
CTD |
PMID:11762555 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
|
|
G |
Mme |
membrane metallo-endopeptidase |
decreases activity |
ISO |
omapatrilat results in decreased activity of MME protein |
CTD |
PMID:18084312 |
|
NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
|
|
G |
Mmel1 |
membrane metallo-endopeptidase-like 1 |
decreases activity |
ISO |
omapatrilat results in decreased activity of MMEL1 protein |
CTD |
PMID:18084312 |
|
NCBI chr 5:165,431,278...165,461,716
Ensembl chr 5:165,431,343...165,461,716
|
|
G |
Nppa |
natriuretic peptide A |
increases expression |
ISO |
omapatrilat results in increased expression of NPPA protein |
CTD |
PMID:11762555 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
|
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
pepstatin inhibits the reaction [AKT1 protein modified form results in increased susceptibility to Etoposide] |
CTD |
PMID:17699715 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
pepstatin inhibits the reaction [Glucosamine results in decreased expression of BCL2L1 protein] |
CTD |
PMID:16850161 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
|
|
G |
Bid |
BH3 interacting domain death agonist |
multiple interactions |
EXP |
pepstatin inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; pepstatin inhibits the reaction [manganese chloride results in increased expression of BID protein]; pepstatin inhibits the reaction [thallium nitrate analog results in increased cleavage of BID protein] |
CTD |
PMID:22669516 PMID:28378122 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP ISO |
pepstatin affects the reaction [thallium nitrate results in increased activity of CASP3 protein]; pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; pepstatin inhibits the reaction [thallium nitrate analog results in increased activity of CASP3 protein] [aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; pepstatin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form] |
CTD |
PMID:22669516 PMID:26853465 PMID:28378122 PMID:31226464 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp8 |
caspase 8 |
multiple interactions |
EXP |
pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein] |
CTD |
PMID:28378122 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
EXP ISO |
pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein] pepstatin inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein modified form]; pepstatin inhibits the reaction [syringic acid analog results in increased secretion of CASP9 protein] |
CTD |
PMID:28378122 PMID:31226464 PMID:34523043 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Ctsb |
cathepsin B |
multiple interactions |
ISO |
[aloxistatin co-treated with pepstatin] results in decreased expression of CTSB protein; [CA 074 methyl ester co-treated with pepstatin] results in decreased expression of CTSB protein |
CTD |
PMID:32186374 |
|
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
|
|
G |
Ctsd |
cathepsin D |
multiple interactions decreases activity |
ISO EXP |
[aloxistatin co-treated with pepstatin] results in decreased expression of CTSD protein; [CA 074 methyl ester co-treated with pepstatin] results in decreased expression of CTSD protein; pepstatin inhibits the reaction [Glucosamine results in decreased expression of CTSD protein alternative form] pepstatin results in decreased activity of CTSD protein |
CTD |
PMID:6497855 PMID:11423908 PMID:16850161 PMID:32186374 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
|
|
G |
Faslg |
Fas ligand |
multiple interactions |
EXP |
pepstatin inhibits the reaction [manganese chloride results in increased expression of FASLG protein] |
CTD |
PMID:28378122 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
|
|
G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
ISO |
pepstatin inhibits the reaction [syringic acid analog results in increased secretion of GAPDH protein] |
CTD |
PMID:34523043 |
|
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
|
|
G |
Hmga1 |
high mobility group AT-hook 1 |
multiple interactions |
ISO |
pepstatin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of HMGA1 mRNA] |
CTD |
PMID:20660070 |
|
NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752
|
|
G |
Inhba |
inhibin subunit beta A |
multiple interactions |
ISO |
pepstatin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of INHBA mRNA] |
CTD |
PMID:20660070 |
|
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
|
|
G |
Lamp2 |
lysosomal-associated membrane protein 2 |
multiple interactions |
ISO |
[aloxistatin co-treated with pepstatin] results in increased expression of LAMP2 protein; [CA 074 methyl ester co-treated with pepstatin] results in increased expression of LAMP2 protein |
CTD |
PMID:32186374 |
|
NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522
|
|
G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
[aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] promotes the reaction [ABTL0812 results in increased expression of and results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] promotes the reaction [Brefeldin A results in increased expression of and results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] promotes the reaction [N-((1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl)octanamide results in increased expression of and results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] results in decreased degradation of MAP1LC3B protein modified form; pepstatin promotes the reaction [BO-1051 results in increased expression of MAP1LC3B protein modified form] [aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] results in increased expression of MAP1LC3B protein |
CTD |
PMID:21184746 PMID:26483381 PMID:27635674 PMID:32397857 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
pepstatin inhibits the reaction [Glucosamine results in increased cleavage of PARP1 protein] |
CTD |
PMID:16850161 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
ISO |
[aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [CA 074 methyl ester co-treated with pepstatin] results in increased expression of SQSTM1 protein [aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [Dronabinol co-treated with aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [HU 211 co-treated with aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein |
CTD |
PMID:26483381 PMID:32186374 PMID:32773031 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
|
|
G |
Stc1 |
stanniocalcin 1 |
multiple interactions |
ISO |
pepstatin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA] |
CTD |
PMID:20660070 |
|
NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
|
|
G |
Tnfaip6 |
TNF alpha induced protein 6 |
multiple interactions |
ISO |
pepstatin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of TNFAIP6 mRNA] |
CTD |
PMID:20660070 |
|
NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
|
|
G |
Tomm20 |
translocase of outer mitochondrial membrane 20 |
multiple interactions |
ISO |
pepstatin inhibits the reaction [Doxorubicin results in decreased expression of TOMM20 protein] |
CTD |
PMID:31226464 |
|
NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198
|
|
|
G |
Slc15a1 |
solute carrier family 15 member 1 |
affects binding |
ISO |
phenylalanylserine analog binds to SLC15A1 protein |
CTD |
PMID:21147219 |
|
NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
|
|
|
G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
phosphoramidon inhibits the reaction [AGT protein results in increased expression of EDNRA protein] |
CTD |
PMID:15007106 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] |
CTD |
PMID:15177934 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Ece1 |
endothelin converting enzyme 1 |
multiple interactions decreases activity |
EXP |
EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]; phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]; phosphoramidon inhibits the reaction [Indomethacin results in increased expression of ECE1 protein] phosphoramidon decreases activity of recombinant Ece1 protein in COS cells |
CTD RGD |
PMID:11145282 PMID:16280098 PMID:8034569 |
RGD:728596 |
NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
|
|
G |
Edn1 |
endothelin 1 |
decreases expression multiple interactions |
EXP |
phosphoramidon results in decreased expression of EDN1 protein EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]; EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]]; phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein] |
CTD |
PMID:11145282 PMID:16280098 PMID:16391412 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
|
|
G |
Ednra |
endothelin receptor type A |
multiple interactions |
EXP |
phosphoramidon inhibits the reaction [AGT protein results in increased expression of EDNRA protein]; phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein] |
CTD |
PMID:15007106 |
|
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
|
|
G |
Ednrb |
endothelin receptor type B |
increases expression |
EXP |
phosphoramidon results in increased expression of EDNRB protein |
CTD |
PMID:15007106 |
|
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
|
|
G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] |
CTD |
PMID:15177934 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
EXP |
phosphoramidon inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form] |
CTD |
PMID:10070497 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Kel |
Kell metallo-endopeptidase (Kell blood group) |
multiple interactions |
ISO |
KEL protein alternative form binds to and affects the metabolism of phosphoramidon |
CTD |
PMID:15769748 |
|
NCBI chr 4:70,568,241...70,585,666
Ensembl chr 4:70,568,243...70,585,631
|
|
G |
Lep |
leptin |
decreases expression |
EXP |
phosphoramidon results in decreased expression of LEP protein |
CTD |
PMID:16391412 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] |
CTD |
PMID:15177934 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:15177934 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mme |
membrane metallo-endopeptidase |
multiple interactions |
EXP |
phosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein] |
CTD |
PMID:10070497 |
|
NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
|
|
G |
Nts |
neurotensin |
multiple interactions |
ISO |
phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:15177934 |
|
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
|
|
G |
Sell |
selectin L |
multiple interactions |
EXP |
phosphoramidon inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form] |
CTD |
PMID:10070497 |
|
NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
|
|
G |
Tac1 |
tachykinin, precursor 1 |
multiple interactions |
EXP |
[TAC1 protein co-treated with phosphoramidon] results in increased uptake of Oxygen |
CTD |
PMID:9808699 |
|
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
|
|
|
G |
Slc22a17 |
solute carrier family 22, member 17 |
increases uptake |
ISO |
SLC22A17 protein results in increased uptake of Phytochelatins |
CTD |
PMID:24518829 |
|
NCBI chr15:28,382,285...28,389,435
Ensembl chr15:28,382,292...28,388,799
|
|
|
G |
Ace |
angiotensin I converting enzyme |
decreases activity multiple interactions |
ISO EXP |
Ramipril results in decreased activity of ACE protein Ramipril inhibits the reaction [Doxorubicin results in increased expression of ACE mRNA] |
CTD |
PMID:3034026 PMID:10543928 PMID:36636964 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
Ramipril inhibits the reaction [Doxorubicin results in increased expression of ACTA2 mRNA] |
CTD |
PMID:36636964 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
|
|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions decreases expression increases expression |
ISO |
candesartan promotes the reaction [Ramipril results in increased expression of ADIPOQ]; Ramipril promotes the reaction [candesartan results in increased expression of ADIPOQ] Ramipril results in decreased expression of ADIPOQ |
CTD |
PMID:17483542 PMID:19059660 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
|
|
G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
EXP |
Ramipril inhibits the reaction [Doxorubicin results in increased expression of AGTR1A mRNA] |
CTD |
PMID:36636964 |
|
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
|
|
G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
EXP |
Ramipril inhibits the reaction [Carbon Tetrachloride results in increased expression of ALPL protein] |
CTD |
PMID:26862777 |
|
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
affects expression |
EXP |
Ramipril affects the expression of BAX protein |
CTD |
PMID:10728395 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
affects expression |
EXP |
Ramipril affects the expression of BCL2 protein |
CTD |
PMID:10728395 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Bmp7 |
bone morphogenetic protein 7 |
multiple interactions |
EXP |
Ramipril inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein] |
CTD |
PMID:17703430 |
|
NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
|
|
G |
Cat |
catalase |
multiple interactions |
EXP |
Ramipril inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] |
CTD |
PMID:26862777 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
[Simvastatin co-treated with Ramipril] results in decreased expression of CCL2 protein |
CTD |
PMID:15184351 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Ccn2 |
cellular communication network factor 2 |
multiple interactions |
EXP |
[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased expression of CCN2 protein |
CTD |
PMID:31062909 |
|
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
|
|
G |
Ces1d |
carboxylesterase 1D |
increases hydrolysis |
ISO |
CES1 protein results in increased hydrolysis of Ramipril |
CTD |
PMID:25445008 |
|
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
EXP |
Ramipril results in decreased expression of COL1A1 mRNA |
CTD |
PMID:11851355 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
|
|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
EXP |
Ramipril inhibits the reaction [Doxorubicin results in increased phosphorylation of CTNNB1 protein] |
CTD |
PMID:36636964 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
|
|
G |
Cyba |
cytochrome b-245 alpha chain |
multiple interactions decreases expression |
ISO |
Ramipril inhibits the reaction [Cyclosporine results in increased expression of CYBA mRNA]; Ramipril inhibits the reaction [Tacrolimus results in increased expression of CYBA mRNA] Ramipril results in decreased expression of CYBA mRNA |
CTD |
PMID:12352326 PMID:16891913 |
|
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
|
|
G |
Cybb |
cytochrome b-245 beta chain |
decreases expression |
ISO |
Ramipril results in decreased expression of CYBB mRNA |
CTD |
PMID:16891913 |
|
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
|
|
G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
Ramipril inhibits the reaction [Doxorubicin results in increased expression of FN1 protein] |
CTD |
PMID:36636964 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
|
|
G |
Foxo3 |
forkhead box O3 |
multiple interactions |
EXP |
[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased phosphorylation of FOXO3 protein |
CTD |
PMID:31062909 |
|
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
|
|
G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
EXP |
Ramipril inhibits the reaction [Carbon Tetrachloride results in increased expression of GOT1 protein] |
CTD |
PMID:26862777 |
|
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
Ramipril inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] |
CTD |
PMID:26862777 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
Ramipril inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] |
CTD |
PMID:36636964 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
Ramipril inhibits the reaction [Doxorubicin results in increased expression of IL6 protein] |
CTD |
PMID:36636964 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Kng1 |
kininogen 1 |
decreases degradation |
EXP |
Ramipril results in decreased degradation of KNG1 protein |
CTD |
PMID:2535056 |
|
NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
|
|
G |
Lep |
leptin |
multiple interactions decreases expression |
ISO |
candesartan promotes the reaction [Ramipril results in increased expression of LEP]; Ramipril promotes the reaction [candesartan results in increased expression of LEP] Ramipril results in decreased expression of LEP |
CTD |
PMID:17483542 PMID:19059660 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
[Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; Ramipril inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:31062909 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression |
EXP |
Ramipril results in decreased expression of MMP2 mRNA |
CTD |
PMID:11851355 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
|
|
G |
Myh7 |
myosin heavy chain 7 |
decreases expression multiple interactions |
EXP |
Ramipril results in decreased expression of MYH7 mRNA Ramipril inhibits the reaction [Doxorubicin results in increased expression of MYH7 mRNA] |
CTD |
PMID:15667801 PMID:36636964 |
|
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
|
|
G |
Nos1 |
nitric oxide synthase 1 |
multiple interactions |
EXP |
[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein; Metoprolol inhibits the reaction [[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein]; Metoprolol inhibits the reaction [Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA]]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA] |
CTD |
PMID:11832429 |
|
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
|
|
G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
NOS3 protein affects the reaction [Ramipril results in increased abundance of Cyclic GMP] |
CTD |
PMID:16891913 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
|
|
G |
Nppb |
natriuretic peptide B |
decreases expression |
EXP |
Ramipril results in decreased expression of NPPB mRNA |
CTD |
PMID:15667801 |
|
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
|
|
G |
Pdgfa |
platelet derived growth factor subunit A |
multiple interactions decreases expression |
ISO |
Ramipril inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PDGFA mRNA] Ramipril results in decreased expression of PDGFA mRNA |
CTD |
PMID:10352363 |
|
NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
|
|
G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions decreases expression |
ISO |
Ramipril inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PDGFB mRNA] Ramipril results in decreased expression of PDGFB mRNA |
CTD |
PMID:10352363 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of PTGS2 protein; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of PTGS2 mRNA] |
CTD |
PMID:11832429 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Ren |
renin |
increases activity increases expression multiple interactions |
ISO EXP |
Ramipril results in increased activity of REN protein Ramipril results in increased expression of REN protein Ramipril inhibits the reaction [Doxorubicin results in increased expression of REN mRNA]; Ramipril inhibits the reaction [Isoproterenol results in increased expression of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased activity of REN protein]; Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of REN mRNA] Ramipril results in increased expression of REN mRNA |
CTD |
PMID:1327051 PMID:9179393 PMID:9539862 PMID:11832429 PMID:14504926 PMID:36636964 More...
|
|
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
|
|
G |
Rhoa |
ras homolog family member A |
multiple interactions |
EXP |
[Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased expression of RHOA protein]; Ramipril inhibits the reaction [Streptozocin results in increased expression of RHOA protein] |
CTD |
PMID:31062909 |
|
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
|
|
G |
Rock2 |
Rho-associated coiled-coil containing protein kinase 2 |
multiple interactions |
EXP |
[Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased expression of ROCK2 protein]; Ramipril inhibits the reaction [Streptozocin results in increased expression of ROCK2 protein] |
CTD |
PMID:31062909 |
|
NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
|
|
G |
Sirt1 |
sirtuin 1 |
multiple interactions |
EXP |
[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased expression of SIRT1 protein |
CTD |
PMID:31062909 |
|
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
|
|
G |
Slc15a1 |
solute carrier family 15 member 1 |
multiple interactions |
ISO |
Ramipril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] |
CTD |
PMID:18713951 |
|
NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
|
|
G |
Slc15a2 |
solute carrier family 15 member 2 |
multiple interactions |
EXP |
Ramipril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] |
CTD |
PMID:18713951 |
|
NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
|
|
G |
Smad2 |
SMAD family member 2 |
multiple interactions |
EXP |
[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased phosphorylation of SMAD2 protein |
CTD |
PMID:31062909 |
|
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions decreases expression decreases activity |
ISO EXP |
Ramipril inhibits the reaction [Cyclosporine results in increased expression of TGFB1 mRNA]; Ramipril inhibits the reaction [Tacrolimus results in increased expression of TGFB1 mRNA] Ramipril results in decreased expression of TGFB1 mRNA [Streptozocin co-treated with Ramipril] results in increased expression of TGFB1 protein; [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased expression of TGFB1 protein; Ramipril inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein] Ramipril results in decreased activity of TGFB1 protein |
CTD |
PMID:12352326 PMID:12631109 PMID:15667801 PMID:17703430 PMID:20551625 PMID:31062909 More...
|
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tgfbr3 |
transforming growth factor beta receptor 3 |
multiple interactions |
EXP |
[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased expression of TGFBR3 protein |
CTD |
PMID:31062909 |
|
NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341
|
|
G |
Timp4 |
TIMP metallopeptidase inhibitor 4 |
increases expression |
EXP |
Ramipril results in increased expression of TIMP4 mRNA |
CTD |
PMID:11851355 |
|
NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Ramipril inhibits the reaction [Doxorubicin results in increased expression of TNF protein] |
CTD |
PMID:36636964 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Wnt3a |
Wnt family member 3A |
multiple interactions |
EXP |
Ramipril inhibits the reaction [Doxorubicin results in increased expression of WNT3A protein] |
CTD |
PMID:36636964 |
|
NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324
|
|
|
G |
Bdkrb2 |
bradykinin receptor B2 |
increases response to substance |
ISO |
BDKRB2 results in increased susceptibility to ramiprilat |
CTD |
PMID:10523327 |
|
NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
|
|
G |
Kng1 |
kininogen 1 |
decreases degradation |
EXP |
ramiprilat results in decreased degradation of KNG1 protein |
CTD |
PMID:2535056 |
|
NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
|
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions decreases activity |
ISO |
Calcium Chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein] |
CTD |
PMID:10086886 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
|
|
|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
affects export multiple interactions increases export affects transport |
ISO |
ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione flavone inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]; hesperetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; Mefloquine inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione]; naringenin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; Quercetin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]; Quercetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; resveratrol inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; Silymarin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; taxifolin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]; verlukast inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione] |
CTD |
PMID:15041478 PMID:16004972 PMID:16156793 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions increases transport affects transport increases export |
EXP ISO |
[Benzbromarone results in decreased activity of ABCC2 protein] inhibits the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]; [Furosemide results in increased activity of ABCC2 protein] promotes the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]; [Spironolactone results in increased expression of ABCC2 protein] which results in increased transport of S-(2,4-dinitrophenyl)glutathione; [sulfanitran results in increased activity of ABCC2 protein] promotes the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]; Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of S-(2,4-dinitrophenyl)glutathione]; S-(2,4-dinitrophenyl)glutathione inhibits the reaction [ABCC2 protein results in increased transport of temocaprilat]; temocaprilat inhibits the reaction [ABCC2 protein results in increased transport of S-(2,4-dinitrophenyl)glutathione]; Ursodeoxycholic Acid promotes the reaction [ABCC2 protein results in increased export of S-(2,4-dinitrophenyl)glutathione] ABCC2 protein affects the transport of S-(2,4-dinitrophenyl)glutathione |
CTD |
PMID:9067317 PMID:9430713 PMID:9525973 PMID:15276087 PMID:15652244 PMID:15846474 PMID:15901347 PMID:19067394 PMID:19766108 PMID:19782883 More...
|
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
|
|
G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
S-(2,4-dinitrophenyl)glutathione inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate] |
CTD |
PMID:11856762 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
|
|
|
G |
Tp53 |
tumor protein p53 |
increases mutagenesis multiple interactions |
ISO |
S-(2-chloroethyl)glutathione results in increased mutagenesis of TP53 gene [S-(2-chloroethyl)glutathione results in increased mutagenesis of TP53 gene] which results in decreased activity of TP53 protein |
CTD |
PMID:14715658 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
|
G |
Adh5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
increases oxidation multiple interactions |
ISO |
ADH5 protein results in increased oxidation of S-hydroxymethylglutathione Cimetidine inhibits the reaction [ADH5 protein results in increased oxidation of S-hydroxymethylglutathione] |
CTD |
PMID:23220590 |
|
NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
|
|
|
G |
Ggt1 |
gamma-glutamyltransferase 1 |
multiple interactions |
ISO |
[hexylglutathione results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione |
CTD |
PMID:19419996 |
|
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
|
|
G |
Gsta1 |
glutathione S-transferase alpha 1 |
affects binding |
ISO |
hexylglutathione binds to GSTA1 protein |
CTD |
PMID:12211029 PMID:15893769 |
|
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
|
|
G |
Gstm2 |
glutathione S-transferase mu 2 |
decreases activity |
ISO |
hexylglutathione results in decreased activity of GSTM2 protein |
CTD |
PMID:10858281 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
hexylglutathione inhibits the reaction [captafol results in decreased activity of GSTP1 protein]; hexylglutathione inhibits the reaction [Captan results in decreased activity of GSTP1 protein] |
CTD |
PMID:8678907 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
|
|
|
G |
Adh5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
multiple interactions |
ISO |
S-methyl glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] |
CTD |
PMID:19428350 |
|
NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
S-methyl glutathione inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein] |
CTD |
PMID:26124276 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
affects transport |
EXP |
ABCC2 affects the transport of S-Nitrosoglutathione |
CTD |
PMID:20683964 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
|
|
G |
Adh5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
increases reduction multiple interactions |
ISO |
ADH5 protein results in increased reduction of S-Nitrosoglutathione decanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; dodecanedioic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; Glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; lauric acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; octanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; pelargonic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; S-methyl glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Ethanol]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Formaldehyde]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Octanols]; sebacic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; undecanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] [SPL-334 results in decreased activity of ADH5 protein] which results in decreased metabolism of S-Nitrosoglutathione |
CTD |
PMID:19038239 PMID:19428350 PMID:26209236 |
|
NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
|
|
G |
Atm |
ATM serine/threonine kinase |
increases response to substance |
ISO |
ATM results in increased susceptibility to S-Nitrosoglutathione |
CTD |
PMID:8958160 |
|
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased expression of BAX protein |
CTD |
PMID:10828028 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased expression of BCL2 protein |
CTD |
PMID:10828028 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Bnip3 |
BCL2 interacting protein 3 |
decreases expression |
ISO |
S-Nitrosoglutathione results in decreased expression of BNIP3 mRNA |
CTD |
PMID:11592958 |
|
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein; [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein] Cyclosporine inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein] |
CTD |
PMID:10205001 PMID:10828028 PMID:20153346 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp8 |
caspase 8 |
increases activity |
ISO |
S-Nitrosoglutathione results in increased activity of CASP8 protein |
CTD |
PMID:20153346 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
G |
Cbr1 |
carbonyl reductase 1 |
multiple interactions increases reduction |
ISO |
[S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 1,4-naphthoquinone]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 2,3-hexanedione]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 4-benzoylpyridine]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Vitamin K 3]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 1,2-naphthoquinone]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 9,10-phenanthrenequinone]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of Isatin]; Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]]; S-Nitrosoglutathione binds to and results in decreased activity of CBR1 protein; S-Nitrosoglutathione binds to and results in increased activity of CBR1 protein; S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione] |
CTD |
PMID:21256830 PMID:23295225 |
|
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
|
|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
decreases secretion |
ISO |
S-Nitrosoglutathione results in decreased secretion of CCL5 protein |
CTD |
PMID:13678430 |
|
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
|
|
G |
Cct7 |
chaperonin containing TCP1 subunit 7 |
multiple interactions |
ISO |
CCT7 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased abundance of Cyclic GMP] |
CTD |
PMID:24213632 |
|
NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580
|
|
G |
Cd86 |
CD86 molecule |
decreases expression |
ISO |
S-Nitrosoglutathione results in decreased expression of CD86 protein |
CTD |
PMID:13678430 |
|
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
|
|
G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions increases expression decreases expression decreases activity |
ISO |
acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of CFTR mRNA]; DDT inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein S-Nitrosoglutathione results in decreased expression of CFTR mRNA S-Nitrosoglutathione results in decreased activity of CFTR protein |
CTD |
PMID:14766015 PMID:15657297 |
|
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
|
|
G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
decreases secretion |
ISO |
S-Nitrosoglutathione results in decreased secretion of CXCL10 protein |
CTD |
PMID:13678430 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
|
|
G |
Faslg |
Fas ligand |
multiple interactions |
ISO |
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter] |
CTD |
PMID:10811113 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
|
|
G |
Gucy1a1 |
guanylate cyclase 1 soluble subunit alpha 1 |
multiple interactions |
ISO |
GUCY1A1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased abundance of Cyclic GMP] |
CTD |
PMID:24213632 |
|
NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression |
ISO |
S-Nitrosoglutathione results in increased expression of HIF1A mRNA |
CTD |
PMID:11514583 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO |
[linsidomine co-treated with S-Nitrosoglutathione] results in increased expression of HMOX1 mRNA; Nitroprusside promotes the reaction [S-Nitrosoglutathione results in increased expression of HMOX1 mRNA]; S-Nitrosoglutathione promotes the reaction [Nitroprusside results in increased expression of HMOX1 mRNA] |
CTD |
PMID:8764571 PMID:10423162 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Htra2 |
HtrA serine peptidase 2 |
multiple interactions affects localization |
ISO |
[tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] |
CTD |
PMID:20153346 |
|
NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
|
|
G |
Ifng |
interferon gamma |
increases secretion |
ISO |
S-Nitrosoglutathione results in increased secretion of IFNG protein |
CTD |
PMID:13678430 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G |
Il10 |
interleukin 10 |
decreases secretion |
ISO |
S-Nitrosoglutathione results in decreased secretion of IL10 protein |
CTD |
PMID:13678430 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
|
|
G |
Il12b |
interleukin 12B |
decreases expression |
ISO |
S-Nitrosoglutathione results in decreased expression of IL12B protein |
CTD |
PMID:13678430 |
|
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
|
|
G |
Il5 |
interleukin 5 |
decreases secretion |
ISO |
S-Nitrosoglutathione results in decreased secretion of IL5 protein |
CTD |
PMID:13678430 |
|
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
|
|
G |
Mgst1 |
microsomal glutathione S-transferase 1 |
affects metabolic processing multiple interactions |
EXP |
S-Nitrosoglutathione affects the metabolism of MGST1 protein [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein] |
CTD |
PMID:16386761 PMID:16899233 |
|
NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
[NOS2 protein results in increased chemical synthesis of S-Nitrosoglutathione] which results in decreased susceptibility to Carmustine |
CTD |
PMID:15110396 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
P4hb |
prolyl 4-hydroxylase subunit beta |
increases nitrosation |
EXP |
S-Nitrosoglutathione results in increased nitrosation of P4HB protein |
CTD |
PMID:28823167 |
|
NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
|
|
G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
multiple interactions |
ISO |
[S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein binds to TP53 promoter]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione inhibits the reaction [PRKN protein binds to TP53 promoter]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione results in increased nitrosation of and affects the localization of PRKN protein |
CTD |
PMID:23985028 |
|
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
|
|
G |
Rasd1 |
ras related dexamethasone induced 1 |
multiple interactions |
EXP |
S-Nitrosoglutathione results in increased nitrosation of and results in increased activity of RASD1 protein |
CTD |
PMID:16908409 |
|
NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
S-Nitrosoglutathione promotes the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein] |
CTD |
PMID:21464294 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Sp1 |
Sp1 transcription factor |
increases activity |
ISO |
S-Nitrosoglutathione results in increased activity of SP1 protein |
CTD |
PMID:14766015 |
|
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
|
|
G |
Sp3 |
Sp3 transcription factor |
decreases activity increases activity |
ISO |
S-Nitrosoglutathione results in decreased activity of SP3 protein S-Nitrosoglutathione results in increased activity of SP3 protein |
CTD |
PMID:14766015 |
|
NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
|
|
G |
Tnf |
tumor necrosis factor |
increases secretion |
ISO |
S-Nitrosoglutathione results in increased secretion of TNF protein |
CTD |
PMID:13678430 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP ISO |
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased expression of TP53 protein [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein binds to TP53 promoter]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione inhibits the reaction [PRKN protein binds to TP53 promoter]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 protein] |
CTD |
PMID:8982730 PMID:23985028 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
|
G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
Saralasin inhibits the reaction [AGT protein affects the localization of Calcium]; Saralasin inhibits the reaction [AGT protein results in increased activity of SERPINE1 protein] |
CTD |
PMID:11244025 PMID:21613610 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Ccn2 |
cellular communication network factor 2 |
multiple interactions |
ISO |
Saralasin inhibits the reaction [Paraquat results in increased expression of CCN2 mRNA]; Saralasin inhibits the reaction [Paraquat results in increased expression of CCN2 protein] |
CTD |
PMID:20035857 |
|
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
Saralasin inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA] |
CTD |
PMID:20035857 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
|
|
G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
Saralasin inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA] |
CTD |
PMID:20035857 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
|
|
G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
EXP |
Saralasin inhibits the reaction [AGT protein results in increased activity of SERPINE1 protein] |
CTD |
PMID:11244025 |
|
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
|
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
affects export |
ISO |
ABCC2 protein affects the export of Sincalide |
CTD |
PMID:15665139 PMID:16046661 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
|
|
G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
EXP |
[Palmitic Acid co-treated with Sincalide] results in increased expression of CEBPA mRNA; [Palmitic Acid co-treated with Sincalide] results in increased expression of CEBPA protein; Quercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of CEBPA protein] |
CTD |
PMID:26873426 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
|
|
G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions |
EXP |
[Palmitic Acid co-treated with Sincalide] results in increased expression of CEBPB mRNA; [Palmitic Acid co-treated with Sincalide] results in increased expression of CEBPB protein; Quercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of CEBPB protein] |
CTD |
PMID:26873426 |
|
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
|
|
G |
Crk |
CRK proto-oncogene, adaptor protein |
multiple interactions increases phosphorylation |
EXP |
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Sincalide results in increased phosphorylation of CRK protein]; Egtazic Acid inhibits the reaction [Sincalide results in increased phosphorylation of CRK protein]; Thapsigargin inhibits the reaction [Sincalide results in increased phosphorylation of CRK protein] |
CTD |
PMID:16187300 |
|
NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
|
|
G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
EXP |
[Palmitic Acid co-treated with Sincalide] results in increased expression of ERN1 mRNA; [Palmitic Acid co-treated with Sincalide] results in increased expression of ERN1 protein; Quercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of ERN1 protein] |
CTD |
PMID:26873426 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
[Palmitic Acid co-treated with Sincalide] results in increased expression of IL1B mRNA; [Palmitic Acid co-treated with Sincalide] results in increased expression of IL1B protein; Quercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of IL1B protein] |
CTD |
PMID:26873426 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
[Palmitic Acid co-treated with Sincalide] results in increased expression of IL6 mRNA; [Palmitic Acid co-treated with Sincalide] results in increased expression of IL6 protein; Quercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of IL6 protein] |
CTD |
PMID:26873426 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
EXP |
[Palmitic Acid co-treated with Sincalide] results in increased degradation of NFKBIA protein; Quercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased degradation of NFKBIA protein] |
CTD |
PMID:26873426 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nfkbib |
NFKB inhibitor beta |
multiple interactions |
EXP |
[Palmitic Acid co-treated with Sincalide] results in increased degradation of NFKBIB protein; Quercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased degradation of NFKBIB protein] |
CTD |
PMID:26873426 |
|
NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
|
|
G |
Rxra |
retinoid X receptor alpha |
affects binding |
EXP |
Sincalide binds to RXRA protein |
CTD |
PMID:31566444 |
|
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
|
|
G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
affects uptake affects import multiple interactions |
ISO |
SLCO1B3 protein affects the uptake of Sincalide SLCO1B3 protein affects the import of Sincalide [icariin results in decreased activity of SLCO1B3 protein] which results in decreased uptake of Sincalide |
CTD |
PMID:15665139 PMID:16046661 PMID:24265111 |
|
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
[Palmitic Acid co-treated with Sincalide] results in increased expression of TNF mRNA; [Palmitic Acid co-treated with Sincalide] results in increased expression of TNF protein; Quercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of TNF protein] |
CTD |
PMID:26873426 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Xbp1 |
X-box binding protein 1 |
multiple interactions |
EXP |
[Palmitic Acid co-treated with Sincalide] results in increased expression of XBP1 mRNA alternative form; [Palmitic Acid co-treated with Sincalide] results in increased expression of XBP1 protein alternative form; Quercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of XBP1 protein alternative form] |
CTD |
PMID:26873426 |
|
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
|
|
|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of CCND1 protein] |
CTD |
PMID:27517622 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Foxm1 |
forkhead box M1 |
multiple interactions |
ISO |
siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of FOXM1 protein] |
CTD |
PMID:27517622 |
|
NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684
|
|
G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of CCND1 protein]; siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of FOXM1 protein]; siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of NFE2L2 protein]; siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of PRDX1 protein] |
CTD |
PMID:27517622 |
|
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
|
|
G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
siomycin A results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
|
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of NFE2L2 protein] |
CTD |
PMID:27517622 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Prdx1 |
peroxiredoxin 1 |
multiple interactions |
ISO |
siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of PRDX1 protein] |
CTD |
PMID:27517622 |
|
NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
|
|
|
G |
Dpp3 |
dipeptidylpeptidase 3 |
multiple interactions |
ISO |
spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine] |
CTD |
PMID:10873616 |
|
NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
|
|
|
G |
Ren |
renin |
increases expression multiple interactions |
EXP |
spirapril results in increased expression of REN mRNA; spirapril results in increased expression of REN protein spirapril promotes the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein] |
CTD |
PMID:1764812 PMID:9300315 |
|
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
|
|
G |
Slc15a1 |
solute carrier family 15 member 1 |
multiple interactions |
ISO |
spirapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] |
CTD |
PMID:18713951 |
|
NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
|
|
G |
Slc15a2 |
solute carrier family 15 member 2 |
multiple interactions |
ISO EXP |
spirapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] |
CTD |
PMID:18713951 |
|
NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
|
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
telaprevir inhibits the reaction [CYP3A4 protein results in increased metabolism of Simvastatin] |
CTD |
PMID:24927617 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
|
|
|
G |
Ces1d |
carboxylesterase 1D |
increases hydrolysis |
ISO |
CES1 protein results in increased hydrolysis of temocapril hydrochloride |
CTD |
PMID:9300133 PMID:15908471 |
|
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
|
|
G |
Nppb |
natriuretic peptide B |
multiple interactions |
ISO |
[carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein |
CTD |
PMID:21378469 |
|
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
|
|
|
G |
Ace |
angiotensin I converting enzyme |
decreases activity |
EXP |
trandolapril results in decreased activity of ACE protein |
CTD |
PMID:27428043 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
|
|
G |
Ace2 |
angiotensin converting enzyme 2 |
multiple interactions |
ISO |
trandolapril promotes the reaction [REN2 protein results in increased expression of ACE2 protein] |
CTD |
PMID:27428043 |
|
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
|
|
G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP |
trandolapril inhibits the reaction [3-nitropropionic acid results in increased activity of ACHE protein] |
CTD |
PMID:25445565 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
|
|
G |
Adrb1 |
adrenoceptor beta 1 |
increases expression |
EXP |
trandolapril results in increased expression of ADRB1 protein |
CTD |
PMID:7586371 |
|
NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
|
|
G |
Agt |
angiotensinogen |
multiple interactions decreases expression |
EXP ISO |
trandolapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein] trandolapril inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form] trandolapril results in decreased expression of AGT protein modified form |
CTD |
PMID:1534315 PMID:27428043 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Cat |
catalase |
multiple interactions |
EXP |
trandolapril inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein] |
CTD |
PMID:25445565 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Cyba |
cytochrome b-245 alpha chain |
multiple interactions decreases expression |
EXP |
[trandolapril co-treated with eplerenone] results in decreased expression of CYBA mRNA trandolapril results in decreased expression of CYBA mRNA |
CTD |
PMID:17324946 |
|
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
|
|
G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
[trandolapril co-treated with eplerenone] results in decreased expression of FN1 protein |
CTD |
PMID:17324946 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
|
|
G |
Ncf1 |
neutrophil cytosolic factor 1 |
multiple interactions decreases expression |
EXP |
[trandolapril co-treated with eplerenone] results in decreased expression of NCF1 mRNA; [trandolapril co-treated with eplerenone] results in decreased expression of NCF1 protein trandolapril results in decreased expression of NCF1 mRNA; trandolapril results in decreased expression of NCF1 protein |
CTD |
PMID:17324946 |
|
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
|
|
G |
Ren |
renin |
multiple interactions increases expression |
ISO EXP |
[Bumetanide co-treated with trandolapril] results in increased expression of REN protein trandolapril results in increased expression of REN protein |
CTD |
PMID:16635047 PMID:27428043 |
|
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
|
|
G |
Slc15a1 |
solute carrier family 15 member 1 |
multiple interactions |
ISO |
trandolapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] |
CTD |
PMID:18713951 |
|
NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
|
|
G |
Slc15a2 |
solute carrier family 15 member 2 |
multiple interactions |
EXP |
trandolapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] |
CTD |
PMID:18713951 |
|
NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
|
|
G |
Sod2 |
superoxide dismutase 2 |
increases expression |
EXP |
trandolapril results in increased expression of SOD2 protein |
CTD |
PMID:17324946 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
|
G |
Hdac1 |
histone deacetylase 1 |
decreases activity |
ISO |
trapoxin B results in decreased activity of HDAC1 protein |
CTD |
PMID:15930892 |
|
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
|
|
G |
Hdac3 |
histone deacetylase 3 |
decreases activity |
ISO |
trapoxin B results in decreased activity of HDAC3 protein |
CTD |
PMID:15930892 |
|
NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
|
|
G |
Hdac6 |
histone deacetylase 6 |
decreases activity |
ISO |
trapoxin B results in decreased activity of HDAC6 protein |
CTD |
PMID:15930892 |
|
NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441
|
|
|
G |
Gnrhr |
gonadotropin releasing hormone receptor |
multiple interactions affects expression |
ISO |
[Estradiol co-treated with Progesterone] inhibits the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA]; Estradiol inhibits the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA]; Progesterone promotes the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA] |
CTD |
PMID:17185802 |
|
NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
|
|
G |
Lhb |
luteinizing hormone subunit beta |
decreases expression increases expression |
EXP |
Triptorelin Pamoate results in decreased expression of LHB protein Triptorelin Pamoate results in increased expression of LHB protein |
CTD |
PMID:3158510 PMID:20463352 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
testosterone enanthate inhibits the reaction [Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]]; testosterone enanthate inhibits the reaction [Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 protein]]; Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]; Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 protein] |
CTD |
PMID:20463352 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Pde5a |
phosphodiesterase 5A |
multiple interactions |
EXP |
[testosterone enanthate co-treated with Triptorelin Pamoate] results in increased expression of PDE5A mRNA; [testosterone enanthate co-treated with Triptorelin Pamoate] results in increased expression of PDE5A protein |
CTD |
PMID:20463352 |
|
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
|
|
G |
Pde6d |
phosphodiesterase 6D |
decreases expression |
EXP |
Triptorelin Pamoate results in decreased expression of PDE6D mRNA |
CTD |
PMID:20463352 |
|
NCBI chr 9:87,192,989...87,237,979
Ensembl chr 9:87,192,983...87,237,969
|
|
G |
Pde9a |
phosphodiesterase 9A |
decreases expression |
EXP |
Triptorelin Pamoate results in decreased expression of PDE9A mRNA |
CTD |
PMID:20463352 |
|
NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948
|
|
G |
Prkg1 |
protein kinase cGMP-dependent 1 |
decreases expression multiple interactions |
EXP |
Triptorelin Pamoate results in decreased expression of PRKG1 mRNA; Triptorelin Pamoate results in decreased expression of PRKG1 protein testosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 mRNA]; testosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 protein] |
CTD |
PMID:20463352 |
|
NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
|
|
G |
Prl |
prolactin |
multiple interactions |
ISO EXP |
Triptorelin Pamoate inhibits the reaction [Sulpiride results in increased abundance of PRL protein] Triptorelin Pamoate inhibits the reaction [Haloperidol results in increased expression of PRL protein] |
CTD |
PMID:2954994 PMID:3158510 |
|
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
|
|
|
G |
Arg1 |
arginase 1 |
decreases activity |
ISO |
trypanothione results in decreased activity of ARG1 protein |
CTD |
PMID:21232540 |
|
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
|
|
|
G |
Arg1 |
arginase 1 |
decreases activity |
ISO |
trypanothione results in decreased activity of ARG1 protein |
CTD |
PMID:21232540 |
|
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
|
|
|
G |
Ghsr |
growth hormone secretagogue receptor |
multiple interactions |
ISO |
ulimorelin binds to and results in increased activity of GHSR protein |
CTD |
PMID:22106937 |
|
NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
|
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
calpain inhibitor III inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein] |
CTD |
PMID:16891617 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
EXP |
calpain inhibitor III inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein] |
CTD |
PMID:29289695 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
|
|
G |
Capn1 |
calpain 1 |
multiple interactions decreases activity |
ISO EXP |
calpain inhibitor III inhibits the reaction [CAPN1 protein results in increased susceptibility to Cisplatin] calpain inhibitor III inhibits the reaction [Calcium results in increased activity of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Manganese results in increased activity of CAPN1 protein] calpain inhibitor III results in decreased activity of CAPN1 protein |
CTD |
PMID:13678654 PMID:20878076 PMID:21985864 PMID:29289695 |
|
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
|
|
G |
Capn2 |
calpain 2 |
multiple interactions |
EXP |
calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein] |
CTD |
PMID:29289695 |
|
NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
calpain inhibitor III inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:16891617 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
calpain inhibitor III inhibits the reaction [deoxynivalenol results in increased degradation of HSPA5 protein] |
CTD |
PMID:19336499 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
|
|
G |
Il1a |
interleukin 1 alpha |
affects localization |
ISO |
calpain inhibitor III affects the localization of IL1A protein |
CTD |
PMID:24024155 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
|
|
G |
Nefl |
neurofilament light chain |
multiple interactions |
EXP |
calpain inhibitor III inhibits the reaction [Zymosan results in increased degradation of NEFL protein] |
CTD |
PMID:15275793 |
|
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
calpain inhibitor III inhibits the reaction [Thioacetamide results in increased expression of NOS2 mRNA] |
CTD |
PMID:15316131 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Sptan1 |
spectrin, alpha, non-erythrocytic 1 |
multiple interactions |
ISO EXP |
calpain inhibitor III inhibits the reaction [lactacystin results in increased cleavage of SPTAN1 protein] calpain inhibitor III inhibits the reaction [Manganese results in increased cleavage of SPTAN1 protein] |
CTD |
PMID:21683092 PMID:21985864 |
|
NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
calpain inhibitor III inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA] |
CTD |
PMID:15316131 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|