imidazole antifungal drug - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	imidazole antifungal drug	go back to main search page
Accession:	CHEBI:87069	browse the term
Definition:	Any imidazole antifungal agent that has been used for the treatment of fungal infections in humans or animals.
Synonyms:	related_synonym:	imidazole antifungal drugs

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Rat (1584) Mouse (1587) Human (1586) Chinchilla (0) Bonobo (0) Dog (4) Squirrel (0) Pig (1) Green Monkey (0) Naked Mole-rat (0) All
Genes (1584)

bifonazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

bifonazole results in decreased activity of CYP19A1 protein

PMID:15554355 PMID:24496634

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

bifonazole results in decreased activity of CYP3A4 protein

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 51

decreases activity

bifonazole results in decreased activity of CYP51A1 protein

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

butoconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

butoconazole results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

nuclear receptor subfamily 1, group I, member 2

increases activity

butoconazole results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

climbazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

climbazole results in increased expression of CYP2B1 mRNA; climbazole results in increased expression of CYP2B1 protein

PMID:11552297 PMID:11824557

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

climbazole results in increased expression of CYP3A2 protein

PMID:11552297 PMID:11824557

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 4, subfamily a, polypeptide 1

increases expression

climbazole results in increased expression of CYP4A1 protein

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

clotrimazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

Clotrimazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Clotrimazole results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

affects binding
multiple interactions
increases expression

Clotrimazole binds to ABCB1 protein
Clotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]
Clotrimazole results in increased expression of ABCB1 protein
Clotrimazole inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]

PMID:8632764 PMID:8917702 PMID:12235267

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 2

increases expression

Clotrimazole results in increased expression of ABCC2 mRNA; Clotrimazole results in increased expression of ABCC2 protein

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

multiple interactions
increases expression

MAPK14 promotes the reaction [Clotrimazole results in increased expression of ABCC3 mRNA]; SB 203580 inhibits the reaction [Clotrimazole results in increased expression of ABCC3 mRNA]

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

acid phosphatase 2, lysosomal

increases expression

Clotrimazole results in increased expression of ACP2 mRNA

NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680

G

ADAM metallopeptidase domain 22

decreases expression

Clotrimazole results in decreased expression of ADAM22 mRNA

NCBI chr 4:25,716,055...25,970,932
Ensembl chr 4:25,715,990...25,964,962

G

ADAM metallopeptidase with thrombospondin type 1 motif, 12

decreases expression

Clotrimazole results in decreased expression of ADAMTS12 mRNA

NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629

G

ADAM metallopeptidase with thrombospondin type 1 motif, 7

increases expression

Clotrimazole results in increased expression of ADAMTS7 mRNA

NCBI chr 8:90,704,727...90,744,333
Ensembl chr 8:90,704,727...90,744,328

G

ADAMTS-like 5

decreases expression

Clotrimazole results in decreased expression of ADAMTSL5 mRNA

NCBI chr 7:9,362,623...9,371,248
Ensembl chr 7:9,363,237...9,370,285

G

adenosine deaminase, RNA-specific

decreases expression

Clotrimazole results in decreased expression of ADAR mRNA

NCBI chr 2:175,138,391...175,178,280
Ensembl chr 2:175,138,403...175,178,282

G

adenylate cyclase 9

decreases activity

Clotrimazole results in decreased activity of ADCY9 protein

NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066

G

adenosine A2a receptor

increases expression

Clotrimazole results in increased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

AE binding protein 1

increases expression

Clotrimazole results in increased expression of AEBP1 mRNA

NCBI chr14:80,738,800...80,748,878
Ensembl chr14:80,738,892...80,748,877

G

ArfGAP with FG repeats 1

increases expression

Clotrimazole results in increased expression of AGFG1 mRNA

NCBI chr 9:84,124,845...84,182,615
Ensembl chr 9:84,125,120...84,178,128

G

aryl hydrocarbon receptor

increases activity

Clotrimazole results in increased activity of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

adenylate kinase 6

increases expression

Clotrimazole results in increased expression of AK6 mRNA

NCBI chr 2:31,794,316...31,806,375
Ensembl chr 2:31,794,519...31,806,371
Ensembl chr20:31,794,519...31,806,371

G

aldehyde dehydrogenase 9 family, member A1

increases expression

Clotrimazole results in increased expression of ALDH9A1 mRNA

NCBI chr13:79,505,738...79,522,539
Ensembl chr13:79,505,695...79,540,568

G

aldolase, fructose-bisphosphate B

affects localization

Clotrimazole affects the localization of ALDOB protein

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

ankyrin repeat domain 40

increases expression

Clotrimazole results in increased expression of ANKRD40 mRNA

NCBI chr10:79,282,075...79,295,322
Ensembl chr10:79,282,075...79,295,320

G

apolipoprotein E

decreases expression

Clotrimazole results in decreased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

arrestin domain containing 1

decreases expression

Clotrimazole results in decreased expression of ARRDC1 mRNA

NCBI chr 3:7,735,002...7,742,195
Ensembl chr 3:7,735,011...7,742,197

G

activating transcription factor 3

increases expression
multiple interactions

Clotrimazole results in increased expression of ATF3 mRNA
SB 203580 inhibits the reaction [Clotrimazole results in increased expression of ATF3 mRNA]

PMID:27507784 PMID:27965148

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATP synthase F1 subunit gamma

increases expression

Clotrimazole results in increased expression of ATP5F1C mRNA

NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367

G

ATP synthase peripheral stalk-membrane subunit b

increases expression

Clotrimazole results in increased expression of ATP5PB mRNA

NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418

G

ATP synthase peripheral stalk subunit d

increases expression

Clotrimazole results in increased expression of ATP5PD mRNA

NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479

G

ATP synthase mitochondrial F1 complex assembly factor 2

increases expression

Clotrimazole results in increased expression of ATPAF2 mRNA

NCBI chr10:45,205,658...45,221,891
Ensembl chr10:45,197,441...45,221,026

G

5-azacytidine induced 2

increases expression

Clotrimazole results in increased expression of AZI2 mRNA

NCBI chr 8:117,773,248...117,797,844
Ensembl chr 8:117,773,279...117,797,847

G

basic leucine zipper ATF-like transcription factor 3

increases expression

Clotrimazole results in increased expression of BATF3 mRNA

NCBI chr13:102,689,657...102,701,241
Ensembl chr13:102,689,657...102,701,139

G

Bardet-Biedl syndrome 4

decreases expression

Clotrimazole results in decreased expression of BBS4 mRNA

NCBI chr 8:59,731,912...59,765,408
Ensembl chr 8:59,731,912...59,765,607

G

branched chain keto acid dehydrogenase E1 subunit alpha

decreases expression

Clotrimazole results in decreased expression of BCKDHA mRNA

NCBI chr 1:81,138,946...81,167,765
Ensembl chr 1:81,138,947...81,167,862

G

basic helix-loop-helix family, member e22

decreases expression

Clotrimazole results in decreased expression of BHLHE22 mRNA

NCBI chr 2:100,486,400...100,489,510
Ensembl chr 2:100,486,400...100,489,510

G

BICD cargo adaptor 2

increases expression

Clotrimazole results in increased expression of BICD2 mRNA

NCBI chr17:15,259,773...15,304,889
Ensembl chr17:15,259,773...15,304,889

G

Bri3 binding protein

increases expression

Clotrimazole results in increased expression of BRI3BP mRNA

NCBI chr12:31,176,742...31,188,563
Ensembl chr12:31,173,971...31,188,572

G

basic transcription factor 3

decreases expression

Clotrimazole results in decreased expression of BTF3 mRNA

NCBI chr 2:29,659,764...29,666,898
Ensembl chr 2:29,659,231...29,666,879

G

C1q and TNF related 1

decreases expression

Clotrimazole results in decreased expression of C1QTNF1 mRNA

NCBI chr10:103,660,319...103,681,662
Ensembl chr10:103,660,327...103,681,660

G

C1q and TNF related 5

increases expression

Clotrimazole results in increased expression of C1QTNF5 mRNA

NCBI chr 8:44,450,934...44,453,075
Ensembl chr 8:44,451,154...44,453,074

G

calcium voltage-gated channel auxiliary subunit beta 1

decreases expression

Clotrimazole results in decreased expression of CACNB1 mRNA

NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694

G

calreticulin

increases expression

Clotrimazole results in increased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

caspase 12

decreases expression

Clotrimazole results in decreased expression of CASP12 mRNA

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions

Clotrimazole inhibits the reaction [Benzo(a)pyrene results in increased expression of CASP3 mRNA]
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of CASP3 protein]

PMID:22033380 PMID:24239969

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP8 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

multiple interactions

[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in decreased activity of CAT protein]; Clotrimazole inhibits the reaction [lead acetate results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

coiled-coil domain containing 17

decreases expression

Clotrimazole results in decreased expression of CCDC17 mRNA

NCBI chr 5:130,051,158...130,056,676
Ensembl chr 5:130,045,938...130,056,673

G

coiled-coil domain containing 28A

decreases expression

Clotrimazole results in decreased expression of CCDC28A mRNA

NCBI chr 1:12,857,668...12,872,944
Ensembl chr 1:12,857,666...12,873,003

G

centriole, cilia and spindle-associated protein

decreases expression

Clotrimazole results in decreased expression of CCSAP mRNA

NCBI chr19:51,824,954...51,843,469
Ensembl chr19:51,826,994...51,842,753

G

Cd81 molecule

increases expression

Clotrimazole results in increased expression of CD81 mRNA

NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660

G

CD93 molecule

increases expression

Clotrimazole results in increased expression of CD93 mRNA

NCBI chr 3:135,891,859...135,898,378
Ensembl chr 3:135,891,859...135,898,378

G

cell death-inducing p53 target 1

decreases expression

Clotrimazole results in decreased expression of CDIP1 mRNA

NCBI chr10:10,773,538...10,796,979
Ensembl chr10:10,774,705...10,796,980

G

cyclin-dependent kinase 1

decreases expression

Clotrimazole results in decreased expression of CDK1

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 4

decreases expression

Clotrimazole results in decreased expression of CDK4

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

decreases expression

Clotrimazole results in decreased expression of CDKN1A

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression

Clotrimazole results in increased expression of CDKN1B

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

CDKN2A interacting protein

decreases expression

Clotrimazole results in decreased expression of CDKN2AIP mRNA

NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033

G

centromere protein J

decreases expression

Clotrimazole results in decreased expression of CENPJ mRNA

NCBI chr15:30,627,206...30,690,384
Ensembl chr15:30,627,224...30,686,791

G

coiled-coil-helix-coiled-coil-helix domain containing 1

increases expression

Clotrimazole results in increased expression of CHCHD1 mRNA

NCBI chr15:3,592,719...3,593,901
Ensembl chr15:3,592,727...3,593,901

G

chromodomain helicase DNA binding protein 2

decreases expression

Clotrimazole results in decreased expression of CHD2 mRNA

NCBI chr 1:127,188,146...127,317,041
Ensembl chr 1:127,190,059...127,300,502

G

carbohydrate sulfotransferase 1

increases expression

Clotrimazole results in increased expression of CHST1 mRNA

NCBI chr 3:78,552,059...78,574,740
Ensembl chr 3:78,548,525...78,574,883

G

ciliary microtubule associated protein 1C

increases expression

Clotrimazole results in increased expression of CIMAP1C mRNA

NCBI chr 8:57,248,746...57,281,084
Ensembl chr 8:57,248,746...57,281,004

G

CDGSH iron sulfur domain 2

increases expression

Clotrimazole results in increased expression of CISD2 mRNA

NCBI chr 2:223,828,937...223,853,768
Ensembl chr 2:223,828,937...223,868,946

G

chloride voltage-gated channel 3

increases expression

Clotrimazole results in increased expression of CLCN3 mRNA

NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119

G

CDC-like kinase 2

decreases expression

Clotrimazole results in decreased expression of CLK2 mRNA

NCBI chr 2:174,570,614...174,582,645
Ensembl chr 2:174,570,653...174,588,985

G

calponin 2

increases expression

Clotrimazole results in increased expression of CNN2 mRNA

NCBI chr 7:9,712,505...9,719,678
Ensembl chr 7:9,712,516...9,719,656

G

collagen type I alpha 1 chain

decreases expression

Clotrimazole results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type VI alpha 2 chain

increases expression

Clotrimazole results in increased expression of COL6A2 mRNA

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

collagen type VII alpha 1 chain

decreases expression

Clotrimazole results in decreased expression of COL7A1 mRNA

NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252

G

collagen type IX alpha 2 chain

decreases expression

Clotrimazole results in decreased expression of COL9A2 mRNA

NCBI chr 5:134,607,616...134,624,678
Ensembl chr 5:134,607,616...134,624,677

G

COMM domain containing 2

increases expression

Clotrimazole results in increased expression of COMMD2 mRNA

NCBI chr 2:141,848,661...141,852,907
Ensembl chr 2:141,848,680...141,852,888

G

coronin 2B

increases expression

Clotrimazole results in increased expression of CORO2B mRNA

NCBI chr 8:62,906,861...63,017,295
Ensembl chr 8:62,906,867...63,017,302

G

cytochrome c oxidase subunit 7A2

increases expression

Clotrimazole results in increased expression of COX7A2 mRNA

NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633
Ensembl chr 8:51,301,168...51,301,633

G

cytochrome c oxidase subunit 8A

increases expression

Clotrimazole results in increased expression of COX8A mRNA

NCBI chr 1:204,402,118...204,404,439

G

carboxypeptidase Z

decreases expression

Clotrimazole results in decreased expression of CPZ mRNA

NCBI chr14:75,223,692...75,246,946
Ensembl chr14:75,223,605...75,246,945

G

cAMP responsive element binding protein 3-like 2

increases expression

Clotrimazole results in increased expression of CREB3L2 mRNA

NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763

G

cysteine-rich secretory protein 1

decreases expression

Clotrimazole results in decreased expression of CRISP1 mRNA

NCBI chr 9:20,741,775...20,768,796
Ensembl chr 9:20,741,777...20,768,796

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity

Clotrimazole results in decreased activity of CYP17A1 protein

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

Clotrimazole results in decreased activity of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases activity

Clotrimazole results in increased expression of CYP1A1 protein
Clotrimazole results in decreased activity of CYP1A1 protein

PMID:7986207 PMID:33814510

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression
multiple interactions

Clotrimazole results in increased expression of CYP1A2 protein
Clotrimazole inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin]

PMID:7986207 PMID:19858067

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Clotrimazole results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily a, polypeptide 2

multiple interactions

Clotrimazole inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline]

NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions
increases activity
increases expression

Clotrimazole inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin]
Clotrimazole results in increased activity of CYP2B1 protein
Clotrimazole results in increased expression of CYP2B1 mRNA; Clotrimazole results in increased expression of CYP2B1 protein

PMID:1372805 PMID:7986207 PMID:19858067 PMID:36356836

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

Clotrimazole results in increased expression of CYP2B2 mRNA; Clotrimazole results in increased expression of CYP2B2 protein

PMID:7986207 PMID:12971794

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases expression
increases activity

Clotrimazole results in increased expression of and results in increased activity of CYP2B6 protein; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]]; NR1I2 protein affects the reaction [Clotrimazole results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]
NR1I3 protein affects the reaction [Clotrimazole results in increased expression of CYP2B10 mRNA]
Clotrimazole results in increased expression of CYP2B6 protein
Clotrimazole results in increased activity of CYP2B6 protein

PMID:12049174 PMID:12571232 PMID:12695351 PMID:14977870

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions
decreases expression

Clotrimazole inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
Clotrimazole results in decreased expression of CYP2C11 protein

PMID:7986207 PMID:19858067

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

Clotrimazole inhibits the reaction [CYP2C6 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity

Clotrimazole results in decreased activity of CYP2C8 protein

PMID:15601807 PMID:33775687

G

cytochrome P450, family 2, subfamily d, polypeptide 2

multiple interactions

Clotrimazole inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]

NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209

G

cytochrome P450, family 2, subfamily j, polypeptide 3

decreases expression

Clotrimazole results in decreased expression of CYP2J3 mRNA

NCBI chr 5:111,219,921...111,244,987
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases activity
increases expression
increases activity

Clotrimazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline]
Clotrimazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Clotrimazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP3A4 mRNA]
Clotrimazole results in decreased activity of CYP3A4 protein
Clotrimazole results in increased expression of CYP3A4 mRNA; Clotrimazole results in increased expression of CYP3A4 protein
Clotrimazole results in increased activity of CYP3A4 protein

PMID:8632764 PMID:12065438 PMID:12505310 PMID:12673034 PMID:14977870 More...

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression
multiple interactions

Clotrimazole results in increased expression of CYP3A23-3A1 mRNA
Clotrimazole inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline]

PMID:12971794 PMID:16125621 PMID:19858067

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression

Clotrimazole results in increased expression of CYP3A5 protein

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 51

decreases activity
decreases response to substance

Clotrimazole results in decreased activity of CYP51A1 protein
CYP51A1 gene results in decreased susceptibility to Clotrimazole

PMID:16989930 PMID:18694951

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

DAB adaptor protein 2

increases expression

Clotrimazole results in increased expression of DAB2 mRNA

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

drebrin 1

increases expression

Clotrimazole results in increased expression of DBN1 mRNA

NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984

G

dachsous cadherin-related 1

increases expression

Clotrimazole results in increased expression of DCHS1 mRNA

NCBI chr 1:160,104,931...160,138,958
Ensembl chr 1:160,104,931...160,124,808

G

doublecortin-like kinase 1

decreases expression

Clotrimazole results in decreased expression of DCLK1 mRNA

NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956

G

DExD-box helicase 39A

increases expression

Clotrimazole results in increased expression of DDX39A mRNA

NCBI chr19:24,418,743...24,427,422
Ensembl chr19:24,418,114...24,426,954

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

Clotrimazole results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

double C2 domain beta

increases expression

Clotrimazole results in increased expression of DOC2B mRNA

NCBI chr10:60,628,029...60,653,267
Ensembl chr10:60,628,029...60,653,267

G

docking protein 4

increases expression

Clotrimazole results in increased expression of DOK4 mRNA

NCBI chr19:10,146,520...10,157,187
Ensembl chr19:10,146,474...10,158,203

G

diphthamide biosynthesis 3

increases expression

Clotrimazole results in increased expression of DPH3 mRNA

NCBI chr16:7,288,295...7,293,734
Ensembl chr16:7,282,705...7,291,265

G

dolichyl-phosphate mannosyltransferase subunit 1, catalytic

increases expression

Clotrimazole results in increased expression of DPM1 mRNA

NCBI chr 3:156,919,979...156,939,522
Ensembl chr 3:156,919,979...156,939,536

G

DS cell adhesion molecule

decreases expression

Clotrimazole results in decreased expression of DSCAM mRNA

NCBI chr11:35,921,924...36,507,100
Ensembl chr11:35,926,896...36,507,415

G

EP300 interacting inhibitor of differentiation 2

increases expression

Clotrimazole results in increased expression of EID2 mRNA

NCBI chr 1:83,538,274...83,539,599

G

eukaryotic translation initiation factor 2A

multiple interactions
increases phosphorylation

[Clotrimazole results in increased phosphorylation of EIF2A protein] which results in increased expression of TMEFF2 protein

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

endoglin

increases expression

Clotrimazole results in increased expression of ENG mRNA

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

erythrocyte membrane protein band 4.1-like 2

increases expression

Clotrimazole results in increased expression of EPB41L2 mRNA

NCBI chr 1:19,863,010...20,037,795
Ensembl chr 1:19,863,009...20,037,721

G

epoxide hydrolase 1

increases activity

Clotrimazole results in increased activity of EPHX1 protein

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

EPS8-like 1

decreases expression

Clotrimazole results in decreased expression of EPS8L1 mRNA

NCBI chr 1:69,343,202...69,359,778
Ensembl chr 1:69,344,243...69,363,524

G

endoplasmic reticulum to nucleus signaling 1

decreases expression

Clotrimazole results in decreased expression of ERN1 mRNA

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

endothelial cell adhesion molecule

increases expression

Clotrimazole results in increased expression of ESAM mRNA

NCBI chr 8:37,238,228...37,249,217
Ensembl chr 8:37,238,287...37,249,215

G

F2R like trypsin receptor 1

multiple interactions

Clotrimazole inhibits the reaction [F2RL1 protein results in increased transport of Chlorides]

NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226

G

family with sequence similarity 110, member B

decreases expression

Clotrimazole results in decreased expression of FAM110B mRNA

NCBI chr 5:18,789,362...18,929,647
Ensembl chr 5:18,789,389...18,929,828

G

family with sequence similarity 120 member B

increases expression

Clotrimazole results in increased expression of FAM120B mRNA

NCBI chr 1:56,320,015...56,385,064
Ensembl chr 1:56,339,129...56,385,061

G

family with sequence similarity 124 member A

decreases expression

Clotrimazole results in decreased expression of FAM124A mRNA

NCBI chr15:36,799,836...36,855,062
Ensembl chr15:36,799,877...36,853,683

G

family with sequence similarity 167, member B

increases expression

Clotrimazole results in increased expression of FAM167B mRNA

NCBI chr 5:141,920,695...141,922,342
Ensembl chr 5:141,920,695...141,922,340

G

FA complementation group I

increases expression

Clotrimazole results in increased expression of FANCI mRNA

NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640

G

Fas cell surface death receptor

multiple interactions

[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of and results in increased activity of FAS protein]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

four and a half LIM domains 2

increases expression

Clotrimazole results in increased expression of FHL2 mRNA

NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

Clotrimazole results in decreased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

follistatin-like 1

increases expression

Clotrimazole results in increased expression of FSTL1 mRNA

NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677

G

FXYD domain-containing ion transport regulator 5

increases expression

Clotrimazole results in increased expression of FXYD5 mRNA

NCBI chr 1:86,267,937...86,277,329
Ensembl chr 1:86,267,406...86,277,519

G

galanin receptor 2

decreases expression

Clotrimazole results in decreased expression of GALR2 mRNA

NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176

G

glucosidase, alpha; neutral C

decreases expression

Clotrimazole results in decreased expression of GANC mRNA

NCBI chr 3:107,353,369...107,406,104
Ensembl chr 3:107,353,369...107,405,241

G

growth associated protein 43

decreases expression

Clotrimazole results in decreased expression of GAP43 mRNA

NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045

G

golgi associated RAB2 interactor 5A

decreases expression

Clotrimazole results in decreased expression of FAM71E1 mRNA

NCBI chr 1:94,988,959...94,995,971
Ensembl chr 1:94,988,613...94,993,539

G

gem (nuclear organelle) associated protein 7-like 1

increases expression

Clotrimazole results in increased expression of GEMIN7L1 mRNA

NCBI chr 4:78,269,910...78,270,681
Ensembl chr 4:78,269,888...78,270,669

G

glial fibrillary acidic protein

increases expression

Clotrimazole results in increased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

gliomedin

decreases expression

Clotrimazole results in decreased expression of GLDN mRNA

NCBI chr 8:54,679,015...54,723,198
Ensembl chr 8:54,679,119...54,723,196

G

glutaredoxin 2

increases expression

Clotrimazole results in increased expression of GLRX2 mRNA

NCBI chr13:55,481,875...55,504,737
Ensembl chr13:55,482,694...55,492,831

G

glutamic-oxaloacetic transaminase 1

multiple interactions

[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glypican 3

decreases expression

Clotrimazole results in decreased expression of GPC3 mRNA

NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798

G

G protein-coupled receptor 62

decreases expression

Clotrimazole results in decreased expression of GPR62 mRNA

NCBI chr 8:107,103,225...107,105,311
Ensembl chr 8:107,103,980...107,105,056

G

glutamic--pyruvic transaminase

multiple interactions

[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

GRAM domain containing 1A

decreases expression

Clotrimazole results in decreased expression of GRAMD1A mRNA

NCBI chr 1:86,367,001...86,393,348
Ensembl chr 1:86,367,001...86,393,336

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

increases expression

Clotrimazole results in increased expression of GRINA mRNA

NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366

G

Gse1 coiled-coil protein

decreases expression

Clotrimazole results in decreased expression of GSE1 mRNA

NCBI chr19:48,274,164...48,629,456
Ensembl chr19:48,274,127...48,629,458

G

glutathione S-transferase alpha 2

increases expression

Clotrimazole results in increased expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase mu 2

decreases expression

Clotrimazole results in decreased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

multiple interactions

Clotrimazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

guanylate cyclase activator 1A

increases expression

Clotrimazole results in increased expression of GUCA1A mRNA

NCBI chr 9:13,588,988...13,598,566
Ensembl chr 9:13,588,525...13,598,565

G

guanylate cyclase 1 soluble subunit alpha 1

increases expression

Clotrimazole results in increased expression of GUCY1A3 mRNA

NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

decreases expression

Clotrimazole results in decreased expression of HERC1 mRNA

NCBI chr 8:66,857,169...67,070,318
Ensembl chr 8:66,856,935...67,070,312

G

huntingtin interacting protein 1

increases expression

Clotrimazole results in increased expression of HIP1 mRNA

NCBI chr12:21,133,364...21,267,796
Ensembl chr12:21,133,406...21,267,725

G

histone cluster 1 H2B family member D

increases expression

Clotrimazole results in increased expression of HIST1H2BD mRNA

NCBI chr17:42,792,887...42,793,268

G

hexokinase 2

affects localization
decreases expression

Clotrimazole affects the localization of HK2 protein
Clotrimazole results in decreased expression of HK2 mRNA

PMID:20724915 PMID:25863232

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

high mobility group box 1

increases expression

Clotrimazole results in increased expression of HMGB1 mRNA

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

HPS4, biogenesis of lysosomal organelles complex 3 subunit 2

decreases expression

Clotrimazole results in decreased expression of HPS4 mRNA

NCBI chr12:44,264,037...44,294,791
Ensembl chr12:44,264,037...44,294,632

G

heat shock transcription factor 1

increases activity

Clotrimazole results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein family A (Hsp70) member 4

increases expression

Clotrimazole results in increased expression of HSPA4 mRNA

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family E (Hsp10) member 1

increases expression

Clotrimazole results in increased expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

interferon-induced protein 44

decreases expression

Clotrimazole results in decreased expression of IFI44 mRNA

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844

G

interferon alpha and beta receptor subunit 2

decreases expression

Clotrimazole results in decreased expression of IFNAR2 mRNA

NCBI chr11:30,613,576...30,645,958
Ensembl chr11:30,613,767...30,668,124

G

insulin-like growth factor 2 mRNA binding protein 2

increases expression

Clotrimazole results in increased expression of IGF2BP2 mRNA

NCBI chr11:78,874,402...78,974,392
Ensembl chr11:78,874,414...78,974,377

G

insulin-like growth factor binding protein 1

increases expression
increases secretion

Clotrimazole results in increased expression of IGFBP1 mRNA
Clotrimazole results in increased secretion of IGFBP1 protein

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

immunoglobulin superfamily, member 10

decreases expression

Clotrimazole results in decreased expression of IGSF10 mRNA

NCBI chr 2:143,575,710...143,605,044
Ensembl chr 2:143,576,070...143,604,773

G

interleukin 34

increases expression

Clotrimazole results in increased expression of IL34 mRNA

NCBI chr19:38,714,990...38,782,749
Ensembl chr19:38,714,991...38,764,000

G

inositol polyphosphate-5-phosphatase D

increases expression

Clotrimazole results in increased expression of INPP5D mRNA

NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746

G

integrator complex subunit 14

increases expression

Clotrimazole results in increased expression of VWA9 mRNA

NCBI chr 8:65,475,788...65,500,807
Ensembl chr 8:65,475,910...65,500,804

G

inositol hexakisphosphate kinase 2

decreases expression

Clotrimazole results in decreased expression of IP6K2 mRNA

NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166

G

integrin subunit alpha 9

increases expression

Clotrimazole results in increased expression of ITGA9 mRNA

NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754

G

integrin subunit beta 1

increases expression

Clotrimazole results in increased expression of ITGB1 mRNA

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

inter-alpha trypsin inhibitor, heavy chain 3

increases expression

Clotrimazole results in increased expression of ITIH3 mRNA

NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Clotrimazole results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium inwardly-rectifying channel, subfamily J, member 1

decreases expression

Clotrimazole results in decreased expression of KCNJ1 mRNA

NCBI chr 8:30,779,883...30,808,607
Ensembl chr 8:30,753,617...30,813,796

G

potassium calcium-activated channel subfamily N member 4

multiple interactions
decreases activity

Clotrimazole inhibits the reaction [[Ionomycin co-treated with Tetraethylammonium] results in increased activity of KCNN4 protein]
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of KCNN4 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of KCNN4 protein]
Clotrimazole results in decreased activity of KCNN4 protein

PMID:14985237 PMID:15921678 PMID:17699636 PMID:20050851 PMID:22033380

NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340

G

lysine demethylase 4A

decreases expression

Clotrimazole results in decreased expression of KDM4A mRNA

NCBI chr 5:131,672,754...131,719,534
Ensembl chr 5:131,672,754...131,719,501

G

lecithin cholesterol acyltransferase

decreases expression

Clotrimazole results in decreased expression of LCAT mRNA

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

LHFPL tetraspan subfamily member 5

decreases expression

Clotrimazole results in decreased expression of LHFPL5 mRNA

NCBI chr20:6,632,324...6,642,534
Ensembl chr20:6,632,362...6,642,532

G

LIM zinc finger domain containing 2

decreases expression

Clotrimazole results in decreased expression of LIMS2 mRNA

NCBI chr18:23,553,937...23,592,137
Ensembl chr18:23,553,937...23,592,137

G

lipase G, endothelial type

decreases expression

Clotrimazole results in decreased expression of LIPG mRNA

NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260

G

lysyl oxidase-like 1

increases expression

Clotrimazole results in increased expression of LOXL1 mRNA

NCBI chr 8:58,691,763...58,716,365
Ensembl chr 8:58,692,593...58,716,356

G

LDL receptor related protein 1

decreases expression

Clotrimazole results in decreased expression of LRP1 mRNA

NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910

G

limbic system-associated membrane protein

decreases expression

Clotrimazole results in decreased expression of LSAMP mRNA

NCBI chr11:58,547,533...60,717,328
Ensembl chr11:58,554,805...60,717,029

G

latent transforming growth factor beta binding protein 4

decreases expression

Clotrimazole results in decreased expression of LTBP4 mRNA

NCBI chr 1:82,600,136...82,634,346
Ensembl chr 1:82,600,136...82,632,178

G

mitogen activated protein kinase 14

multiple interactions

MAPK14 promotes the reaction [Clotrimazole results in increased expression of ABCC3 mRNA]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

microtubule-associated protein tau

decreases expression

Clotrimazole results in decreased expression of MAPT mRNA

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

myristoylated alanine rich protein kinase C substrate

increases expression

Clotrimazole results in increased expression of MARCKS mRNA

NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012

G

microtubule affinity regulating kinase 3

increases expression

Clotrimazole results in increased expression of MARK3 mRNA

NCBI chr 6:130,626,612...130,716,245
Ensembl chr 6:130,627,482...130,716,647

G

muscleblind-like splicing regulator 1

decreases expression

Clotrimazole results in decreased expression of MBNL1 mRNA

NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368

G

multiple coagulation factor deficiency 2, ER cargo receptor complex subunit

increases expression

Clotrimazole results in increased expression of MCFD2 mRNA

NCBI chr 6:7,274,469...7,285,841
Ensembl chr 6:7,274,469...7,285,841

G

microfibril associated protein 2

decreases expression

Clotrimazole results in decreased expression of MFAP2 mRNA

NCBI chr 5:153,312,068...153,320,266
Ensembl chr 5:153,314,711...153,320,259

G

mirror-image polydactyly 1

decreases expression

Clotrimazole results in decreased expression of MIPOL1 mRNA

NCBI chr 6:74,755,293...75,090,403
Ensembl chr 6:74,755,395...75,086,811

G

microRNA 96

increases expression

Clotrimazole results in increased expression of MIR96 mRNA

NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516

G

MLLT3, super elongation complex subunit

increases expression

Clotrimazole results in increased expression of MLLT3 mRNA

NCBI chr 5:102,259,075...102,515,447
Ensembl chr 5:102,260,011...102,515,361

G

maturin, neural progenitor differentiation regulator homolog

decreases expression

Clotrimazole results in decreased expression of MTURN mRNA

NCBI chr 4:83,807,528...83,828,494
Ensembl chr 4:83,807,579...83,824,950

G

matrix remodeling associated 8

decreases expression

Clotrimazole results in decreased expression of MXRA8 mRNA

NCBI chr 5:166,448,919...166,453,645
Ensembl chr 5:166,449,154...166,453,636

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

Clotrimazole results in decreased expression of MYC protein

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myc target 1

increases expression

Clotrimazole results in increased expression of MYCT1 mRNA

NCBI chr 1:42,018,137...42,029,410
Ensembl chr 1:42,018,137...42,029,410

G

myelin expression factor 2

increases expression

Clotrimazole results in increased expression of MYEF2 mRNA

NCBI chr 3:112,338,241...112,374,122
Ensembl chr 3:112,338,241...112,374,181

G

myosin light chain 9

increases expression

Clotrimazole results in increased expression of MYL9 mRNA

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

myosin XVI

increases expression

Clotrimazole results in increased expression of MYO16 mRNA

NCBI chr16:78,884,405...79,364,445
Ensembl chr16:78,884,406...79,248,388

G

myosin Ib

increases expression

Clotrimazole results in increased expression of MYO1B mRNA

NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798

G

N-acetylated alpha-linked acidic dipeptidase-like 2

decreases expression

Clotrimazole results in decreased expression of NAALADL2 mRNA

NCBI chr 2:106,639,146...107,992,218
Ensembl chr 2:106,645,608...107,991,689

G

NACC family member 2

decreases expression

Clotrimazole results in decreased expression of NACC2 mRNA

NCBI chr 3:8,879,952...8,946,660
Ensembl chr 3:8,883,065...8,946,660

G

nuclear receptor coactivator 1

multiple interactions

Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
Clotrimazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]

PMID:17998298 PMID:18973326 PMID:21924250

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

nuclear receptor co-repressor 1

multiple interactions

Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOR1 protein]

NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032

G

Nedd4 family interacting protein 2

increases expression

Clotrimazole results in increased expression of NDFIP2 mRNA

NCBI chr15:82,032,366...82,087,043
Ensembl chr15:82,032,366...82,086,317

G

NADH:ubiquinone oxidoreductase subunit A5

increases expression

Clotrimazole results in increased expression of NDUFA5 mRNA

NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598

G

NADH:ubiquinone oxidoreductase complex assembly factor 7

increases expression

Clotrimazole results in increased expression of NDUFAF7 mRNA

NCBI chr 6:16,108,630...16,119,810
Ensembl chr 6:16,103,003...16,119,810

G

NADH:ubiquinone oxidoreductase subunit B5

increases expression

Clotrimazole results in increased expression of NDUFB5 mRNA

NCBI chr 2:115,519,248...115,533,589
Ensembl chr 2:115,519,154...115,533,589

G

NADH:ubiquinone oxidoreductase core subunit S3

increases expression

Clotrimazole results in increased expression of NDUFS3 mRNA

NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824

G

NADH:ubiquinone oxidoreductase subunit S6

increases expression

Clotrimazole results in increased expression of NDUFS6 mRNA

NCBI chr 1:29,968,833...29,977,423
Ensembl chr 1:29,968,842...29,977,467

G

NEDD4 E3 ubiquitin protein ligase

decreases expression

Clotrimazole results in decreased expression of NEDD4 mRNA

NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951

G

niban apoptosis regulator 1

increases expression

Clotrimazole results in increased expression of FAM129A mRNA

NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729

G

nidogen 1

increases expression

Clotrimazole results in increased expression of NID1 mRNA

NCBI chr17:86,085,133...86,158,272
Ensembl chr17:86,085,077...86,158,267

G

nipsnap homolog 1

decreases expression

Clotrimazole results in decreased expression of NIPSNAP1 mRNA

NCBI chr14:79,734,234...79,758,101
Ensembl chr14:79,734,209...79,758,098

G

nipsnap homolog 3A (C. elegans)

increases expression

Clotrimazole results in increased expression of NIPSNAP3B mRNA

NCBI chr 5:67,613,993...67,625,067
Ensembl chr 5:67,614,036...67,669,700

G

NIN1 (RPN12) binding protein 1 homolog

decreases expression

Clotrimazole results in decreased expression of NOB1 mRNA

NCBI chr19:35,322,803...35,335,354
Ensembl chr19:35,322,669...35,346,815

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity
increases expression

Clotrimazole binds to and results in increased activity of NR1I2 protein; Clotrimazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Clotrimazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]]; NR1I2 protein affects the reaction [Clotrimazole results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]; NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP3A4 mRNA]
Clotrimazole results in increased activity of NR1I2 protein
Clotrimazole results in increased expression of NR1I2 mRNA

PMID:12049174 PMID:12065438 PMID:12695351 PMID:14977870 PMID:15548381 More...

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions
decreases activity
increases activity
affects binding

1,1-bis(4-hydroxyphenyl)cyclohexane inhibits the reaction [Clotrimazole binds to NR1I3 protein]; 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Clotrimazole binds to NR1I3 protein]; androstan-3-ol inhibits the reaction [Clotrimazole binds to NR1I3 protein]; bisphenol A inhibits the reaction [Clotrimazole binds to NR1I3 protein]; bisphenol B inhibits the reaction [Clotrimazole binds to NR1I3 protein]; Clotrimazole binds to and affects the activity of NR1I3 protein; Clotrimazole binds to and results in decreased activity of NR1I3 protein; Clotrimazole binds to and results in increased activity of and results in increased localization of NR1I3 protein mutant form; Clotrimazole binds to and results in increased activity of NR1I3 protein alternative form; Clotrimazole inhibits the reaction [4-nonylphenol results in increased activity of NR1I3 protein]; Clotrimazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime binds to and results in increased activity of NR1I3 protein mutant form]; Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
Clotrimazole results in decreased activity of NR1I3 protein
Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein alternative form
Clotrimazole results in decreased activity of NR1I3 protein; Clotrimazole results in decreased activity of NR1I3 protein alternative form
Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein alternative form; Clotrimazole results in increased activity of NR1I3 protein mutant form
androstan-3-ol inhibits the reaction [Clotrimazole results in increased activity of NR1I3 protein mutant form]; Clotrimazole inhibits the reaction [androstan-3-ol results in decreased activity of NR1I3 protein alternative form]; Clotrimazole inhibits the reaction [Imidazoles results in decreased activity of NR1I3 protein alternative form]; Imidazoles inhibits the reaction [Clotrimazole results in increased activity of NR1I3 protein mutant form]
Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein mutant form
Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]; Clotrimazole promotes the reaction [NR1I3 protein modified form binds to NCOR1 protein]; NR1I3 protein affects the reaction [Clotrimazole results in increased expression of CYP2B10 mRNA]

PMID:12049174 PMID:15905360 PMID:16919048 PMID:18973326 PMID:20686338 More...

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Clotrimazole results in increased expression of CYP2B6 mRNA]]]

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

neuronal cell adhesion molecule

decreases expression

Clotrimazole results in decreased expression of NRCAM mRNA

NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992

G

NSFL1 cofactor

increases expression

Clotrimazole results in increased expression of NSFL1C mRNA

NCBI chr 3:139,978,306...140,002,876
Ensembl chr 3:139,978,301...140,002,870

G

NudC domain containing 2

increases expression

Clotrimazole results in increased expression of NUDCD2 mRNA

NCBI chr10:25,163,247...25,168,738
Ensembl chr10:25,163,220...25,168,738

G

nudix hydrolase 12

decreases expression

Clotrimazole results in decreased expression of NUDT12 mRNA

NCBI chr 9:98,741,627...98,755,039
Ensembl chr 9:98,742,360...98,755,039

G

ornithine decarboxylase 1

increases expression

Clotrimazole results in increased expression of ODC1 mRNA

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

optineurin

increases expression

Clotrimazole results in increased expression of OPTN mRNA

NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251

G

origin recognition complex, subunit 1

increases expression

Clotrimazole results in increased expression of ORC1 mRNA

NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375

G

purinergic receptor P2X 3

decreases expression

Clotrimazole results in decreased expression of P2RX3 mRNA

NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178

G

pecanex 4

decreases expression

Clotrimazole results in decreased expression of PCNXL4 mRNA

NCBI chr 6:91,125,063...91,170,423
Ensembl chr 6:91,125,063...91,170,439

G

platelet derived growth factor receptor beta

increases expression

Clotrimazole results in increased expression of PDGFRB mRNA

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

pyruvate dehydrogenase complex, component X

increases expression

Clotrimazole results in increased expression of PDHX mRNA

NCBI chr 3:89,372,248...89,431,779
Ensembl chr 3:89,371,497...89,431,773

G

protein disulfide isomerase family A, member 4

increases expression

Clotrimazole results in increased expression of PDIA4 mRNA

NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107

G

peroxisomal biogenesis factor 2

increases expression

Clotrimazole results in increased expression of PEX2 mRNA

NCBI chr 2:96,050,380...96,072,928
Ensembl chr 2:96,045,958...96,073,404

G

phosphofructokinase, muscle

decreases expression

Clotrimazole results in decreased expression of PFKM mRNA

NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192

G

phosphofructokinase, platelet

affects localization

Clotrimazole affects the localization of PFKP protein

NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018

G

PHD finger protein 1

decreases expression

Clotrimazole results in decreased expression of PHF1 mRNA

NCBI chr20:5,017,765...5,022,872
Ensembl chr20:5,017,893...5,022,871

G

protein inhibitor of activated STAT, 1

decreases expression

Clotrimazole results in decreased expression of PIAS1 mRNA

NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905

G

PTEN induced kinase 1

decreases expression

Clotrimazole results in decreased expression of PINK1 mRNA

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

phospholipase A1 member A

increases expression

Clotrimazole results in increased expression of PLA1A mRNA

NCBI chr11:62,320,112...62,357,779
Ensembl chr11:62,320,493...62,357,779

G

plasminogen activator, urokinase

decreases expression

Clotrimazole results in decreased expression of PLAU mRNA

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

phospholipase C, eta 2

decreases expression

Clotrimazole results in decreased expression of PLCH2 mRNA

NCBI chr 5:165,544,209...165,613,769
Ensembl chr 5:165,544,200...165,602,356

G

pleckstrin homology domain containing O1

increases expression

Clotrimazole results in increased expression of PLEKHO1 mRNA

NCBI chr 2:183,544,487...183,552,928
Ensembl chr 2:183,544,499...183,552,785

G

podocalyxin-like

increases expression

Clotrimazole results in increased expression of PODXL mRNA

NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899

G

DNA polymerase epsilon 3, accessory subunit

increases expression

Clotrimazole results in increased expression of POLE3 mRNA

NCBI chr 5:75,973,941...75,977,175
Ensembl chr 5:75,974,717...75,977,231
Ensembl chr 7:75,974,717...75,977,231

G

protein phosphatase, Mg2+/Mn2+ dependent, 1J

decreases expression

Clotrimazole results in decreased expression of PPM1J mRNA

NCBI chr 2:192,278,597...192,283,883
Ensembl chr 2:192,278,517...192,283,882

G

protein phosphatase 1, regulatory subunit 9A

decreases expression

Clotrimazole results in decreased expression of PPP1R9A mRNA

NCBI chr 4:32,970,501...33,292,360
Ensembl chr 4:33,024,450...33,286,907

G

peroxiredoxin 2

multiple interactions

[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of PRDX2 protein]; [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]]; Clotrimazole inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]]

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

protein kinase C, eta

increases expression

Clotrimazole results in increased expression of PRKCH mRNA

NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654

G

protein kinase D2

decreases expression

Clotrimazole results in decreased expression of PRKD2 mRNA

NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376

G

paired related homeobox 1

increases expression

Clotrimazole results in increased expression of PRRX1 mRNA

NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866

G

serine protease 41

decreases expression

Clotrimazole results in decreased expression of PRSS41 mRNA

NCBI chr10:12,865,872...12,873,552
Ensembl chr10:12,865,872...12,873,552

G

PC4 and SRSF1 interacting protein 1

increases expression

Clotrimazole results in increased expression of PSIP1 mRNA

NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257

G

prostaglandin F2 receptor inhibitor

increases expression

Clotrimazole results in increased expression of PTGFRN mRNA

NCBI chr 2:188,469,521...188,544,795
Ensembl chr 2:188,469,521...188,544,795

G

RAB11 family interacting protein 4

increases expression

Clotrimazole results in increased expression of RAB11FIP4 mRNA

NCBI chr10:64,550,109...64,658,123
Ensembl chr10:64,550,177...64,654,759

G

RAB9A, member RAS oncogene family

decreases expression

Clotrimazole results in decreased expression of RAB9A mRNA

NCBI chr X:27,955,552...28,009,870
Ensembl chr X:27,952,204...28,001,622

G

RAD18 E3 ubiquitin protein ligase

increases expression

Clotrimazole results in increased expression of RAD18 mRNA

NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069

G

ralA binding protein 1

decreases expression

Clotrimazole results in decreased expression of RALBP1 mRNA

NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707

G

Ras interacting protein 1

increases expression

Clotrimazole results in increased expression of RASIP1 mRNA

NCBI chr 1:96,097,135...96,109,564
Ensembl chr 1:96,091,074...96,109,562

G

retinol binding protein 2

increases expression

Clotrimazole results in increased expression of RBP2 mRNA

NCBI chr 8:99,079,293...99,104,489
Ensembl chr 8:99,079,104...99,104,473

G

replication factor C subunit 2

increases expression

Clotrimazole results in increased expression of RFC2 mRNA

NCBI chr12:22,120,449...22,133,576
Ensembl chr12:22,120,010...22,133,557

G

raftlin family member 2

decreases expression

Clotrimazole results in decreased expression of RFTN2 mRNA

NCBI chr 9:56,651,617...56,707,830
Ensembl chr 9:56,630,460...56,707,810

G

regucalcin

decreases expression

Clotrimazole results in decreased expression of RGN mRNA

NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450

G

regulator of G-protein signaling 5

increases expression

Clotrimazole results in increased expression of RGS5 mRNA

NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518

G

regulator of G protein signaling 9 binding protein

decreases expression

Clotrimazole results in decreased expression of RGS9BP mRNA

NCBI chr 1:88,249,438...88,250,151
Ensembl chr 1:88,249,438...88,250,151

G

Rab interacting lysosomal protein-like 1

decreases expression

Clotrimazole results in decreased expression of RILPL1 mRNA

NCBI chr12:32,071,870...32,109,687
Ensembl chr12:32,071,693...32,109,938

G

ring finger protein 8

decreases expression

Clotrimazole results in decreased expression of RNF8 mRNA

NCBI chr20:7,682,258...7,710,448
Ensembl chr20:7,682,322...7,708,491

G

ribosomal protein S27-like

increases expression

Clotrimazole results in increased expression of RPS27L mRNA

NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418

G

ribosomal protein S6 kinase B2

decreases expression

Clotrimazole results in decreased expression of RPS6KB2 mRNA

NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078

G

round spermatid basic protein 1

decreases expression

Clotrimazole results in decreased expression of RSBN1 mRNA

NCBI chr 2:191,416,631...191,470,711
Ensembl chr 2:191,416,631...191,470,711

G

schwannomin interacting protein 1

increases expression

Clotrimazole results in increased expression of SCHIP1 mRNA

NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585

G

succinate dehydrogenase complex subunit D

increases expression

Clotrimazole results in increased expression of SDHD mRNA

NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238

G

SUMO specific peptidase 7

decreases expression

Clotrimazole results in decreased expression of SENP7 mRNA

NCBI chr11:44,423,733...44,584,129
Ensembl chr11:44,423,735...44,564,711

G

SUMO peptidase family member, NEDD8 specific

decreases expression

Clotrimazole results in decreased expression of SENP8 mRNA

NCBI chr 8:60,135,446...60,148,836
Ensembl chr 8:60,121,714...60,148,928

G

serpin family F member 1

decreases expression

Clotrimazole results in decreased expression of SERPINF1 mRNA

NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646

G

serum/glucocorticoid regulated kinase 1

increases expression

Clotrimazole results in increased expression of SGK1 mRNA

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

sialic acid binding Ig like lectin 1

decreases expression

Clotrimazole results in decreased expression of SIGLEC1 mRNA

NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850

G

signal-induced proliferation-associated 1

increases expression

Clotrimazole results in increased expression of SIPA1 mRNA

NCBI chr 1:202,938,532...202,950,672
Ensembl chr 1:202,938,580...202,950,591

G

solute carrier family 19 member 1

multiple interactions
decreases activity

Clotrimazole inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]
Clotrimazole results in decreased activity of SLC19A1 protein

NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972

G

solute carrier family 25 member 14

decreases expression

Clotrimazole results in decreased expression of SLC25A14 mRNA

NCBI chr X:127,807,630...127,845,823
Ensembl chr X:127,807,449...127,845,823

G

sphingomyelin phosphodiesterase 1

multiple interactions

[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of SMPD1 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of SMPD1 protein]

NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794

G

small nuclear ribonucleoprotein U4/U6.U5 subunit 27

increases expression

Clotrimazole results in increased expression of SNRNP27 mRNA

NCBI chr 4:119,123,676...119,133,234
Ensembl chr 4:119,121,877...119,133,234

G

sorting nexin 16

decreases expression

Clotrimazole results in decreased expression of SNX16 mRNA

NCBI chr 2:91,335,896...91,357,622
Ensembl chr 2:91,336,092...91,357,619

G

sorting nexin 24

decreases expression

Clotrimazole results in decreased expression of SNX24 mRNA

NCBI chr18:46,670,987...46,826,070
Ensembl chr18:46,671,443...46,826,068

G

sorting nexin 33

decreases expression

Clotrimazole results in decreased expression of SNX33 mRNA

NCBI chr 8:57,315,861...57,328,522
Ensembl chr 8:57,317,161...57,327,538

G

sorbitol dehydrogenase

increases expression

Clotrimazole results in increased expression of SORD mRNA

NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133

G

serine palmitoyltransferase, small subunit A

increases expression

Clotrimazole results in increased expression of SPTSSA mRNA

NCBI chr 6:72,144,714...72,156,130
Ensembl chr 6:72,144,714...72,156,214

G

signal recognition particle 9

increases expression

Clotrimazole results in increased expression of SRP9 mRNA

NCBI chr13:93,832,580...93,840,720
Ensembl chr13:93,832,580...93,840,720

G

sushi-repeat-containing protein, X-linked

decreases expression

Clotrimazole results in decreased expression of SRPX mRNA

NCBI chr X:12,676,984...12,751,296
Ensembl chr X:12,566,645...12,747,882

G

sushi-repeat-containing protein, X-linked 2

increases expression

Clotrimazole results in increased expression of SRPX2 mRNA

NCBI chr X:97,106,455...97,132,197
Ensembl chr X:97,106,561...97,132,195

G

sarcospan

decreases expression

Clotrimazole results in decreased expression of SSPN mRNA

NCBI chr 4:178,890,030...178,946,267
Ensembl chr 4:178,897,147...178,931,554

G

SH3 and cysteine rich domain

increases expression

Clotrimazole results in increased expression of STAC mRNA

NCBI chr 8:111,530,800...111,653,228
Ensembl chr 8:111,530,800...111,654,008

G

stonin 1

decreases expression

Clotrimazole results in decreased expression of RAET1L mRNA

NCBI chr 6:5,843,186...5,892,557
Ensembl chr 6:5,843,185...5,892,449

G

serine/threonine/tyrosine interacting-like 1

decreases expression

Clotrimazole results in decreased expression of STYXL1 mRNA

NCBI chr12:20,907,410...20,940,232
Ensembl chr12:20,907,435...20,939,752

G

sulfotransferase family 1A member 1

decreases expression

Clotrimazole results in decreased expression of SULT1A1 mRNA

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 2A member 1

decreases expression

Clotrimazole results in decreased expression of SULT2A1 mRNA

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

SURF1, cytochrome c oxidase assembly factor

decreases expression

Clotrimazole results in decreased expression of SURF1 mRNA

NCBI chr 3:10,241,793...10,244,686
Ensembl chr 3:10,241,837...10,263,315

G

spectrin repeat containing nuclear envelope protein 2

decreases expression

Clotrimazole results in decreased expression of SYNE2 mRNA

NCBI chr 6:94,537,088...94,848,085
Ensembl chr 6:94,537,088...94,848,064

G

tafazzin, phospholipid-lysophospholipid transacylase

increases expression

Clotrimazole results in increased expression of TAZ mRNA

NCBI chr X:152,065,539...152,076,178
Ensembl chr X:152,065,609...152,074,001

G

transgelin

increases expression

Clotrimazole results in increased expression of TAGLN mRNA

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

tet methylcytosine dioxygenase 3

decreases expression

Clotrimazole results in decreased expression of TET3 mRNA

NCBI chr 4:115,867,412...115,964,433
Ensembl chr 4:115,871,265...115,964,193

G

transforming growth factor, beta 1

increases expression

Clotrimazole results in increased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta induced

decreases expression

Clotrimazole results in decreased expression of TGFBI mRNA

NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240

G

THAP domain containing 3

decreases expression

Clotrimazole results in decreased expression of THAP3 mRNA

NCBI chr 5:162,488,480...162,494,149
Ensembl chr 5:162,488,480...162,494,149

G

transmembrane p24 trafficking protein 4

increases expression

Clotrimazole results in increased expression of TMED4 mRNA

NCBI chr14:81,125,049...81,129,646
Ensembl chr14:81,125,053...81,129,631

G

transmembrane p24 trafficking protein 7

increases expression

Clotrimazole results in increased expression of TMED7 mRNA

NCBI chr18:39,318,564...39,325,640
Ensembl chr18:39,297,351...39,325,640

G

transmembrane protein with EGF-like and two follistatin-like domains 2

multiple interactions

[Clotrimazole results in increased phosphorylation of EIF2A protein] which results in increased expression of TMEFF2 protein

NCBI chr 9:50,445,947...50,733,473
Ensembl chr 9:50,436,079...50,733,475

G

transmembrane protein 116

decreases expression

Clotrimazole results in decreased expression of TMEM116 mRNA

NCBI chr12:35,021,912...35,089,409
Ensembl chr12:35,041,572...35,089,430

G

transmembrane protein 39b

decreases expression

Clotrimazole results in decreased expression of TMEM39B mRNA

NCBI chr 5:142,024,271...142,046,607
Ensembl chr 5:142,024,273...142,046,549

G

transmembrane protein 88

increases expression

Clotrimazole results in increased expression of TMEM88 mRNA

NCBI chr10:54,118,752...54,120,447
Ensembl chr10:54,118,752...54,120,447

G

transmembrane protein 97

increases expression

Clotrimazole results in increased expression of TMEM97 mRNA

NCBI chr10:63,438,228...63,447,311
Ensembl chr10:63,438,222...63,589,730

G

transmembrane serine protease 9

decreases expression

Clotrimazole results in decreased expression of TMPRSS9 mRNA

NCBI chr 7:8,810,321...8,831,177
Ensembl chr 7:8,810,320...8,831,177

G

tankyrase 1 binding protein 1

increases expression

Clotrimazole results in increased expression of TNKS1BP1 mRNA

NCBI chr 3:70,135,335...70,160,071
Ensembl chr 3:70,137,837...70,160,038

G

tenascin XA, pseudogene 1

decreases expression

Clotrimazole results in decreased expression of TNXA-PS1 mRNA

NCBI chr20:4,026,471...4,027,826

G

tumor protein p53

increases expression

Clotrimazole results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tropomyosin 2

increases expression

Clotrimazole results in increased expression of TPM2 mRNA

NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992

G

Tnf receptor associated factor 4

increases expression

Clotrimazole results in increased expression of TRAF4 mRNA

NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284

G

transient receptor potential cation channel, subfamily C, member 6

increases expression

Clotrimazole results in increased expression of TRPC6 mRNA

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

G

transient receptor potential cation channel, subfamily M, member 2

multiple interactions

Clotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]]
[Clotrimazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium]

PMID:21900507 PMID:22036725

NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181

G

thiosulfate sulfurtransferase like domain containing 2

decreases expression

Clotrimazole results in decreased expression of TSTD2 mRNA

NCBI chr 5:60,371,751...60,415,916
Ensembl chr 5:60,393,454...60,415,916

G

tetratricopeptide repeat domain 33

decreases expression

Clotrimazole results in decreased expression of TTC33 mRNA

NCBI chr 2:54,279,906...54,326,851
Ensembl chr 2:54,279,997...54,323,871

G

tubulin, beta 2A class IIa

increases expression

Clotrimazole results in increased expression of TUBB2A mRNA

NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714

G

taxilin alpha

increases expression

Clotrimazole results in increased expression of TXLNA mRNA

NCBI chr 5:141,969,337...141,985,054
Ensembl chr 5:141,969,346...141,984,583

G

U2 snRNP-associated SURP domain containing

decreases expression

Clotrimazole results in decreased expression of U2SURP mRNA

NCBI chr 8:96,018,932...96,075,795
Ensembl chr 8:96,022,957...96,075,691

G

UDP glucuronosyltransferase family 1 member A1

affects expression

Clotrimazole affects the expression of UGT1A1 mRNA

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UPF2, regulator of nonsense mediated mRNA decay

decreases expression

Clotrimazole results in decreased expression of UPF2 mRNA

NCBI chr17:72,224,575...72,335,896
Ensembl chr17:72,225,316...72,335,855

G

ubiquinol-cytochrome c reductase, complex III subunit X

increases expression

Clotrimazole results in increased expression of UQCR10 mRNA

NCBI chr14:79,566,151...79,569,017
Ensembl chr14:79,566,157...79,569,003

G

vasohibin 2

increases expression

Clotrimazole results in increased expression of VASH2 mRNA

NCBI chr13:102,529,718...102,561,204
Ensembl chr13:102,529,719...102,560,391

G

vascular endothelial growth factor A

multiple interactions
increases secretion

[Clotrimazole co-treated with Imatinib Mesylate] results in increased secretion of VEGFA protein
Clotrimazole results in increased secretion of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

Wnt family member 2

decreases expression

Clotrimazole results in decreased expression of WNT2 mRNA

NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402

G

exportin 4

decreases expression

Clotrimazole results in decreased expression of XPO4 mRNA

NCBI chr15:31,717,016...31,807,723
Ensembl chr15:31,716,762...31,807,908

G

zinc finger and BTB domain containing 10

decreases expression

Clotrimazole results in decreased expression of ZBTB10 mRNA

NCBI chr 2:92,475,254...92,509,892
Ensembl chr 2:92,479,014...92,512,515

G

zinc finger protein 407

increases expression

Clotrimazole results in increased expression of ZFP407 mRNA

NCBI chr18:77,571,140...77,970,282
Ensembl chr18:77,571,204...77,974,129

G

zinc finger and SCAN domain containing 2

decreases expression

Clotrimazole results in decreased expression of ZSCAN2 mRNA

NCBI chr 1:134,833,701...134,848,957
Ensembl chr 1:134,833,871...134,848,952

econazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate cyclase 9

increases activity

Econazole results in increased activity of ADCY9 protein

NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases expression
decreases activity

Econazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; Econazole promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]
Econazole results in increased expression of CYP3A4 mRNA
Econazole results in decreased activity of CYP3A4 protein

PMID:15135088 PMID:17998298

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 51

decreases response to substance

CYP51A1 gene results in decreased susceptibility to Econazole

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

glutathione S-transferase pi 1

multiple interactions

Econazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

potassium voltage-gated channel subfamily A member 3

multiple interactions
decreases activity

[Econazole results in decreased activity of KCNA3 protein] which results in decreased import of Thallium

NCBI chr 2:194,632,106...194,634,059
Ensembl chr 2:194,632,196...194,650,138

G

potassium voltage-gated channel subfamily H member 2

decreases activity
multiple interactions

Econazole results in decreased activity of KCNH2 protein
[Econazole results in decreased activity of KCNH2 protein] which results in decreased import of Thallium

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

nuclear receptor coactivator 1

multiple interactions

Econazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Econazole binds to and results in increased activity of NR1I2 protein; Econazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Econazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

[tebuconazole co-treated with Econazole] results in increased phosphorylation of PRKAA1 protein

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

[tebuconazole co-treated with Econazole] results in increased phosphorylation of PRKAA2 protein

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

solute carrier family 22 member 2

multiple interactions

Econazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

transient receptor potential cation channel, subfamily M, member 2

multiple interactions

[Econazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium]

NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181

G

unc-51 like autophagy activating kinase 1

multiple interactions

[tebuconazole co-treated with Econazole] results in increased phosphorylation of ULK1 protein; dorsomorphin inhibits the reaction [[tebuconazole co-treated with Econazole] results in increased phosphorylation of ULK1 protein]

NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966

enilconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases expression

enilconazole results in decreased expression of ABCB11 mRNA

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily C member 2

decreases expression

enilconazole results in decreased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

decreases expression
multiple interactions
increases expression

enilconazole results in decreased expression of ABCC3 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of ABCC3 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of ABCC3 mRNA
enilconazole results in increased expression of ABCC3 mRNA

PMID:29451352 PMID:33426623

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily D member 3

decreases expression

enilconazole results in decreased expression of ABCD3 mRNA

NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020

G

acyl-CoA oxidase 1

decreases expression

enilconazole results in decreased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

adenosine kinase

increases expression

enilconazole results in increased expression of ADK mRNA

NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510

G

aldehyde dehydrogenase 1 family, member A1

decreases expression
multiple interactions
increases expression

enilconazole results in decreased expression of ALDH1A1 mRNA
[thiacloprid co-treated with enilconazole] results in decreased expression of ALDH1A1 mRNA
enilconazole results in increased expression of ALDH1A1 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of ALDH1A1 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of ALDH1A1 mRNA

PMID:32201337 PMID:33426623

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 2 family member

decreases expression
multiple interactions

enilconazole results in decreased expression of ALDH2 mRNA
[Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in decreased expression of ALDH2 mRNA; [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in decreased expression of and results in decreased activity of ALDH2 protein

PMID:32201337 PMID:34830855

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

anoctamin 1

decreases expression

enilconazole results in decreased expression of ANO1 mRNA

NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069

G

annexin A10

increases expression

enilconazole results in increased expression of ANXA10 mRNA

NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648

G

androgen receptor

multiple interactions
affects binding
decreases expression

Dihydrotestosterone inhibits the reaction [enilconazole results in increased activity of AR protein]; enilconazole inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; enilconazole inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; enilconazole inhibits the reaction [Metribolone results in increased activity of AR protein]
enilconazole binds to AR protein
enilconazole results in decreased expression of AR mRNA

PMID:15064155 PMID:18324785 PMID:21310686 PMID:30853599 PMID:33049310

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

arginase 1

decreases expression

enilconazole results in decreased expression of ARG1 mRNA

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

ATPase phospholipid transporting 8B1

increases expression

enilconazole results in increased expression of ATP8B1 mRNA

NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396

G

catalase

increases expression

enilconazole results in increased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 5

increases expression

enilconazole results in increased expression of CCL5 mRNA

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

carboxylesterase 2H

multiple interactions
decreases expression

[enilconazole co-treated with thiacloprid] results in increased expression of CES2 protein
enilconazole results in decreased expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

CF transmembrane conductance regulator

affects binding
decreases expression

enilconazole binds to CFTR protein
enilconazole results in decreased expression of CFTR mRNA; enilconazole results in decreased expression of CFTR protein

PMID:29106682 PMID:32814239

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

catechol-O-methyltransferase

increases expression

enilconazole results in increased expression of COMT protein

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

cytochrome P450, family 11, subfamily a, polypeptide 1

affects expression

enilconazole affects the expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases expression

enilconazole results in increased expression of CYP17A1 mRNA

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity
affects secretion

enilconazole results in decreased activity of CYP19A1 protein
enilconazole affects the secretion of CYP19A1 mRNA

PMID:10806373 PMID:15554355 PMID:26141389 PMID:30853599

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
multiple interactions
increases expression

enilconazole results in increased activity of CYP1A1 protein
enilconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
enilconazole results in increased expression of CYP1A1 mRNA; enilconazole results in increased expression of CYP1A1 protein

PMID:19070657 PMID:21762035 PMID:32194361

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects expression
multiple interactions

enilconazole affects the expression of CYP1A2 mRNA
[clothianidin co-treated with enilconazole] results in increased expression of CYP1A2 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP1A2 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression
multiple interactions

enilconazole results in increased expression of CYP1B1 mRNA
[clothianidin co-treated with enilconazole] results in increased expression of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 27, subfamily a, polypeptide 1

increases expression

enilconazole results in increased expression of CYP27A1 mRNA

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression
multiple interactions

enilconazole results in increased expression of CYP2B2 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of CYP2B2 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP2B2 mRNA

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases expression
affects expression

[enilconazole co-treated with thiacloprid] results in increased expression of CYP2B6 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CYP2B9 protein; [thiacloprid co-treated with enilconazole] results in increased expression of CYP2B6 mRNA
enilconazole results in increased expression of CYP2B10
enilconazole affects the expression of CYP2B6 mRNA

PMID:27853109 PMID:32201337

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases expression

enilconazole results in decreased expression of CYP2C19 mRNA; enilconazole results in decreased expression of CYP2C19 protein

PMID:32194361 PMID:32201337

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases expression

[clothianidin co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA
enilconazole results in decreased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects expression
decreases activity
multiple interactions
increases expression

enilconazole affects the expression of CYP3A4 mRNA
enilconazole results in decreased activity of CYP3A4 protein
[Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein; [clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 mRNA; [clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 protein; [enilconazole co-treated with methidathion] results in increased expression of CYP3A4 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP3A4 mRNA; [enilconazole co-treated with thiacloprid] results in increased expression of CYP3A4 protein; [thiacloprid co-treated with enilconazole] results in increased expression of CYP3A4 mRNA
enilconazole results in increased expression of CYP3A4 protein

PMID:21762035 PMID:25028461 PMID:32201337 PMID:34273450

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions
increases expression

[enilconazole co-treated with clothianidin] results in increased expression of CYP3A23-3A1 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP3A23-3A1 mRNA
enilconazole results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression
multiple interactions

enilconazole results in increased expression of CYP3A5 mRNA; enilconazole results in increased expression of CYP3A5 protein
[clothianidin co-treated with enilconazole] results in increased expression of CYP3A5 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CYP3A5 protein

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 51

decreases activity

enilconazole results in decreased activity of CYP51A1 protein

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

cytochrome P450 family 7 subfamily A member 1

decreases expression
multiple interactions

enilconazole results in decreased expression of CYP7A1 mRNA
[enilconazole co-treated with clothianidin] results in decreased expression of CYP7A1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of CYP7A1 mRNA
enilconazole results in decreased expression of CYP7A1 mRNA; enilconazole results in decreased expression of CYP7A1 protein

PMID:29451352 PMID:32194361 PMID:32201337 PMID:32814239 PMID:33426623

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 7 subfamily B member 1

decreases expression

enilconazole results in decreased expression of CYP7B1 mRNA

NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698

G

cytochrome P450 family 8 subfamily B member 1

increases expression

enilconazole results in increased expression of CYP8B1 mRNA

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

defensin alpha 3

decreases expression

enilconazole results in decreased expression of DEFA3 mRNA

NCBI chr16:70,533,436...70,535,592
Ensembl chr16:70,533,436...70,535,604

G

dynamin 1

decreases expression

enilconazole results in decreased expression of DNM1 mRNA

NCBI chr 3:15,604,782...15,648,654
Ensembl chr 3:15,604,784...15,648,538

G

elastin

decreases expression
multiple interactions

enilconazole results in decreased expression of ELN mRNA
[enilconazole co-treated with clothianidin] results in decreased expression of ELN mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of ELN mRNA

NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928

G

estrogen receptor 1

multiple interactions

enilconazole binds to and results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

decreases expression
multiple interactions

enilconazole results in decreased expression of ESR2 mRNA
enilconazole binds to and results in increased activity of ESR2 protein

PMID:30853599 PMID:33049310

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

fatty acid binding protein 6

decreases expression

enilconazole results in decreased expression of FABP6 mRNA

NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282

G

Fas cell surface death receptor

increases expression

enilconazole results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fibroblast growth factor 19

decreases expression
increases expression

enilconazole results in decreased expression of FGF15 mRNA
enilconazole results in increased expression of FGF15 mRNA

PMID:29451352 PMID:32814239

NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

enilconazole results in decreased expression of G6PC1 mRNA

PMID:32194361 PMID:32201337

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glutathione peroxidase 1

increases expression

enilconazole results in increased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

decreases expression

enilconazole results in decreased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione-disulfide reductase

increases expression

enilconazole results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

decreases expression

enilconazole results in decreased expression of GSS mRNA

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

H2A.X variant histone

multiple interactions

[Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

3-hydroxyanthranilate 3,4-dioxygenase

decreases expression

enilconazole results in decreased expression of HAAO mRNA

NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877

G

3-hydroxy-3-methylglutaryl-CoA reductase

affects expression

enilconazole affects the expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

affects expression

enilconazole affects the expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

hydroxysteroid (17-beta) dehydrogenase 13

decreases expression

enilconazole results in decreased expression of HSD17B13 mRNA

NCBI chr14:5,751,697...5,766,809
Ensembl chr14:5,752,132...5,768,166

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

affects expression

enilconazole affects the expression of HSD3B1 mRNA

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

interferon gamma

increases expression

enilconazole results in increased expression of IFNG mRNA

PMID:27393971 PMID:32814239

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 17A

multiple interactions
increases expression

enilconazole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]
enilconazole results in increased expression of IL17A mRNA

PMID:22289359 PMID:32814239

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 1 alpha

increases expression

enilconazole results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression

enilconazole results in increased expression of IL1B mRNA

PMID:27393971 PMID:32814239

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression

enilconazole results in increased expression of IL6 mRNA

PMID:27393971 PMID:32201337 PMID:32814239

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

enilconazole results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

ketohexokinase

decreases expression

enilconazole results in decreased expression of KHK mRNA

NCBI chr 6:25,445,298...25,455,834
Ensembl chr 6:25,445,300...25,455,717

G

KLF transcription factor 4

affects expression
decreases expression

enilconazole affects the expression of KLF4 mRNA
enilconazole results in decreased expression of KLF4 mRNA

PMID:29106682 PMID:32814239

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

kyphoscoliosis peptidase

multiple interactions
decreases expression

[enilconazole co-treated with clothianidin] results in decreased expression of KY mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of KY mRNA
enilconazole results in decreased expression of KY mRNA

NCBI chr 8:103,086,959...103,126,305
Ensembl chr 8:103,086,630...103,126,024

G

lipocalin 2

increases expression

enilconazole results in increased expression of LCN2

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

luteinizing hormone subunit beta

decreases expression

enilconazole results in decreased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

lipoprotein lipase

increases expression

enilconazole results in increased expression of LPL mRNA

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

lymphocyte antigen 6 family member D

decreases expression

enilconazole results in decreased expression of LY6D mRNA

NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:106,643,232...106,644,733

G

mitogen-activated protein kinase 8

increases expression

enilconazole results in increased expression of MAPK8 mRNA

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

multiple EGF-like-domains 11

multiple interactions
decreases expression

[enilconazole co-treated with clothianidin] results in decreased expression of MEGF11 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of MEGF11 mRNA
enilconazole results in decreased expression of MEGF11 mRNA

NCBI chr 8:64,892,312...65,218,984
Ensembl chr 8:64,892,387...65,216,061

G

meprin A subunit beta

affects expression
decreases expression

enilconazole affects the expression of MEP1B mRNA
enilconazole results in decreased expression of MEP1B mRNA

PMID:29106682 PMID:32814239

NCBI chr18:12,366,126...12,392,840
Ensembl chr18:12,365,289...12,392,840

G

MLX interacting protein-like

decreases expression

enilconazole results in decreased expression of MLXIPL mRNA

NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112

G

membrane metallo-endopeptidase

multiple interactions
increases expression

[enilconazole co-treated with clothianidin] results in increased expression of MME mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of MME mRNA
enilconazole results in increased expression of MME mRNA

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

microsomal triglyceride transfer protein

decreases expression

enilconazole results in decreased expression of MTTP mRNA

NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239

G

mucin 1, cell surface associated

affects expression
decreases expression

enilconazole affects the expression of MUC1 mRNA
enilconazole results in decreased expression of MUC1 mRNA

PMID:29106682 PMID:32814239

NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733

G

mucin 17, cell surface associated

decreases expression

enilconazole results in decreased expression of MUC17 mRNA

NCBI chr12:19,527,251...19,536,924
Ensembl chr12:19,527,321...19,538,522

G

mucin 2, oligomeric mucus/gel-forming

affects expression
decreases expression

enilconazole affects the expression of MUC2 mRNA
enilconazole results in decreased expression of MUC2 mRNA

PMID:29106682 PMID:32814239

NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756

G

nuclear receptor subfamily 0, group B, member 2

multiple interactions
decreases expression

[clothianidin co-treated with enilconazole] results in decreased expression of NR0B2 mRNA
enilconazole results in decreased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group H, member 4

decreases expression
increases expression

enilconazole results in decreased expression of NR1H4 mRNA
enilconazole results in increased expression of NR1H4 mRNA

PMID:29451352 PMID:32814239

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

[enilconazole co-treated with methidathion] results in increased activity of NR1I2 protein; enilconazole binds to and results in increased activity of NR1I2 protein; enilconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]
enilconazole results in increased activity of NR1I2 protein

PMID:16565514 PMID:17438109 PMID:21115097 PMID:25028461 PMID:29973476 More...

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions
affects response to substance

enilconazole binds to and results in increased activity of NR1I3 protein; enilconazole inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]
NR1I3 protein affects the susceptibility to enilconazole

PMID:18832183 PMID:27853109

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

pyruvate dehydrogenase kinase 4

decreases expression

enilconazole results in decreased expression of PDK4 mRNA

NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850

G

patatin-like phospholipase domain containing 3

decreases expression

enilconazole results in decreased expression of PNPLA3 mRNA

NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077

G

peroxisome proliferator-activated receptor gamma

multiple interactions

enilconazole binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

decreases expression

enilconazole results in decreased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[enilconazole binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

retinoic acid receptor, alpha

increases activity

enilconazole results in increased activity of RARA protein

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

retinoic acid receptor, gamma

increases activity

enilconazole results in increased activity of RARG protein

NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177

G

resistin like beta

affects expression

enilconazole affects the expression of RETNLB mRNA

NCBI chr11:51,983,482...51,985,368
Ensembl chr11:51,983,483...51,985,368

G

regulator of cell cycle

increases expression

enilconazole results in increased expression of RGCC mRNA

NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141

G

RAR-related orphan receptor A

multiple interactions

enilconazole binds to and results in decreased activity of RORA protein

NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931

G

stearoyl-CoA desaturase

decreases expression

enilconazole results in decreased expression of SCD mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

solute carrier family 10 member 1

decreases expression

enilconazole results in decreased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 10 member 2

increases expression

enilconazole results in increased expression of SLC10A2 mRNA

NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475

G

solute carrier family 12 member 2

decreases expression

enilconazole results in decreased expression of SLC12A2 mRNA; enilconazole results in decreased expression of SLC12A2 protein

PMID:29106682 PMID:32814239

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 22 member 5

decreases expression

enilconazole results in decreased expression of SLC22A5 mRNA; enilconazole results in decreased expression of SLC22A5 protein

NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 26 member 3

decreases expression

enilconazole results in decreased expression of SLC26A3 mRNA; enilconazole results in decreased expression of SLC26A3 protein

PMID:29106682 PMID:32814239

NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772

G

solute carrier family 26 member 6

decreases expression

enilconazole results in decreased expression of SLC26A6 mRNA; enilconazole results in decreased expression of SLC26A6 protein

PMID:29106682 PMID:32814239

NCBI chr 8:109,558,968...109,569,778
Ensembl chr 8:109,559,642...109,569,778

G

solute carrier family 6 member 1

multiple interactions

[enilconazole co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of SLC6A1 mRNA

NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293

G

solute carrier family 9 member A3

decreases expression

enilconazole results in decreased expression of SLC9A3 mRNA

PMID:29106682 PMID:32814239

NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417

G

solute carrier organic anion transporter family, member 4a1

increases expression

enilconazole results in increased expression of SLCO4A1 mRNA

NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305

G

superoxide dismutase 1

increases expression

enilconazole results in increased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression

enilconazole results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

steroidogenic acute regulatory protein

affects expression
decreases expression

enilconazole affects the expression of STAR mRNA
enilconazole results in decreased expression of STAR mRNA

PMID:30853599 PMID:36410587

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

sulfotransferase family 1B member 1

decreases expression

enilconazole results in decreased expression of SULT1B1 mRNA

NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483

G

sulfotransferase family 1C member 2A

increases expression

enilconazole results in increased expression of SULT1C2 mRNA

NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734

G

trefoil factor 3

decreases expression

enilconazole results in decreased expression of TFF3 mRNA

NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054

G

thyroid hormone receptor alpha

multiple interactions

enilconazole binds to and results in decreased activity of THRA protein

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

tumor necrosis factor

increases expression

enilconazole results in increased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

UDP glucuronosyltransferase family 2 member B7

decreases expression

enilconazole results in decreased expression of UGT2B7 mRNA

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

isoconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

isoconazole results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

ketoconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

decreases expression

Ketoconazole results in decreased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

aminoadipate aminotransferase

affects expression

Ketoconazole affects the expression of AADAT mRNA

NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332

G

angio-associated, migratory cell protein

increases expression

Ketoconazole results in increased expression of AAMP mRNA

NCBI chr 9:75,863,382...75,869,188
Ensembl chr 9:75,863,389...75,868,547

G

apoptosis antagonizing transcription factor

decreases expression

Ketoconazole results in decreased expression of AATF mRNA

NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201

G

4-aminobutyrate aminotransferase

increases expression

Ketoconazole results in increased expression of ABAT mRNA

NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835

G

ATP binding cassette subfamily A member 1

multiple interactions
decreases expression

Ketoconazole inhibits the reaction [Clofibrate results in increased expression of ABCA1 mRNA]
Ketoconazole results in decreased expression of ABCA1 mRNA

PMID:14690017 PMID:37077353

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily A member 3

decreases expression

Ketoconazole results in decreased expression of ABCA3 mRNA

NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

[Ketoconazole results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Ketoconazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]

PMID:20147439 PMID:20829430 PMID:23956101 PMID:24014644 PMID:28437613

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

increases transport
decreases expression
multiple interactions
affects expression
decreases activity

ABCB1 protein results in increased transport of Ketoconazole
Ketoconazole results in decreased expression of ABCB1A mRNA
Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCB1A mRNA]
Ketoconazole affects the expression of ABCB1 mRNA
Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein]
Ketoconazole results in decreased expression of ABCB1 mRNA
Ketoconazole results in decreased activity of ABCB1 protein
[Ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; Ketoconazole binds to and results in decreased activity of ABCB1 protein; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Glucosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Lactosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Ketoconazole inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Ethanol results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Hydrogen Peroxide affects the expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCB1 mRNA]

PMID:10350002 PMID:12235267 PMID:14662772 PMID:15969931 PMID:16819505 More...

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 4

decreases activity
multiple interactions

Ketoconazole results in decreased activity of ABCB4 protein
[Chenodeoxycholic Acid co-treated with Ketoconazole] results in increased expression of ABCB4 mRNA

PMID:28437613 PMID:30985903

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 1

multiple interactions

Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCC1 mRNA]

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

decreases activity
multiple interactions

Ketoconazole results in decreased activity of ABCC2 protein
Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA]

PMID:19070657 PMID:19766108

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily D member 2

increases expression

Ketoconazole results in increased expression of ABCD2 mRNA

NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642

G

ATP binding cassette subfamily G member 2

multiple interactions
increases expression

Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCG2 mRNA]
Ketoconazole results in increased expression of ABCG2 mRNA

PMID:32185415 PMID:37077353

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ABRA C-terminal like

decreases expression

Ketoconazole results in decreased expression of ABRACL mRNA

NCBI chr 1:12,654,951...12,665,143
Ensembl chr 1:12,654,838...12,665,207

G

acetyl-CoA acyltransferase 1A

increases expression

Ketoconazole results in increased expression of ACAA1 mRNA

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acetyl-CoA acyltransferase 2

increases expression

Ketoconazole results in increased expression of ACAA2 mRNA

NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249

G

acyl-CoA dehydrogenase, long chain

increases expression

Ketoconazole results in increased expression of ACADL mRNA

NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220

G

acyl-CoA dehydrogenase medium chain

increases expression

Ketoconazole results in increased expression of ACADM mRNA

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

acyl-CoA dehydrogenase short chain

increases expression

Ketoconazole results in increased expression of ACADS mRNA

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

G

angiotensin converting enzyme 2

increases expression

Ketoconazole results in increased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acyl-CoA thioesterase 8

increases expression

Ketoconazole results in increased expression of ACOT8 mRNA

NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851

G

acyl-CoA synthetase long-chain family member 4

decreases expression

Ketoconazole results in decreased expression of ACSL4 mRNA

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

acyl-CoA synthetase long-chain family member 5

increases expression

Ketoconazole results in increased expression of ACSL5 mRNA

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

acyl-CoA synthetase medium-chain family member 1

decreases expression

Ketoconazole results in decreased expression of ACSM1 mRNA

NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495

G

ADAM metallopeptidase domain 9

affects expression

Ketoconazole affects the expression of ADAM9 mRNA

NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917

G

adenylate cyclase 6

decreases expression

Ketoconazole results in decreased expression of ADCY6 mRNA

NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

decreases expression

Ketoconazole results in decreased expression of ADH1 mRNA

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

acireductone dioxygenase 1

decreases expression

Ketoconazole results in decreased expression of ADI1 mRNA

NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842

G

adiponectin, C1Q and collagen domain containing

increases expression

Ketoconazole results in increased expression of ADIPOQ mRNA

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adiponectin receptor 2

increases expression

Ketoconazole results in increased expression of ADIPOR2 mRNA

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

adenosine A1 receptor

increases expression

Ketoconazole results in increased expression of ADORA1 mRNA

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adrenoceptor beta 2

increases expression

Ketoconazole results in increased expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

AE binding protein 2

decreases expression

Ketoconazole results in decreased expression of AEBP2 mRNA

NCBI chr 4:173,527,881...173,566,033
Ensembl chr 4:173,528,344...173,593,100

G

alkylglycerone phosphate synthase

increases expression

Ketoconazole results in increased expression of AGPS mRNA

NCBI chr 3:60,747,323...60,845,831
Ensembl chr 3:60,747,323...60,845,830

G

agouti related neuropeptide

decreases expression

Ketoconazole results in decreased expression of AGRP mRNA

NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584

G

angiotensinogen

increases expression

Ketoconazole results in increased expression of AGT mRNA

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aryl hydrocarbon receptor

multiple interactions
increases expression
increases activity

AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]
Ketoconazole results in increased expression of AHR mRNA
Ketoconazole results in increased activity of AHR protein
[Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; Ketoconazole results in increased activity of and results in increased localization of AHR protein
Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein]

PMID:17505019 PMID:17923278 PMID:21753779 PMID:25000292 PMID:31168027

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aryl-hydrocarbon receptor repressor

multiple interactions
increases expression

[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of AHRR mRNA
Ketoconazole results in increased expression of AHRR mRNA

NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673

G

alpha-2-HS-glycoprotein

increases expression

Ketoconazole results in increased expression of AHSG mRNA

NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999

G

A-kinase anchoring protein 12

decreases expression

Ketoconazole results in decreased expression of AKAP12 mRNA

NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886

G

aldo-keto reductase family 1, member B7

increases expression

Ketoconazole results in increased expression of AKR1B7 mRNA

NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502

G

aldo-keto reductase family 1, member C15

increases expression

Ketoconazole results in increased expression of AKR1C15 mRNA

NCBI chr17:66,181,493...66,208,090
Ensembl chr17:66,181,493...66,208,061

G

5'-aminolevulinate synthase 1

increases expression

Ketoconazole results in increased expression of ALAS1 mRNA

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

albumin

affects expression

Ketoconazole affects the expression of ALB mRNA

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

affects expression

Ketoconazole affects the expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 7 family, member A1

decreases expression

Ketoconazole results in decreased expression of ALDH7A1 mRNA

NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193

G

alkB homolog 7

decreases expression

Ketoconazole results in decreased expression of ALKBH7 mRNA

NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

Ketoconazole inhibits the reaction [Calcifediol results in increased expression of ALPL mRNA]
Ketoconazole results in increased expression of ALPL protein

PMID:21542014 PMID:31099283

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

amidohydrolase domain containing 1

decreases expression

Ketoconazole results in decreased expression of AMDHD1 mRNA

NCBI chr 7:28,043,923...28,059,156
Ensembl chr 7:28,043,716...28,059,156

G

anti-Mullerian hormone

increases expression

Ketoconazole results in increased expression of AMH protein

NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282

G

angiogenin

increases expression

Ketoconazole results in increased expression of ANG mRNA

NCBI chr15:24,312,711...24,323,361

G

annexin A1

decreases expression

Ketoconazole results in decreased expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

aldehyde oxidase 1

decreases expression

Ketoconazole results in decreased expression of AOX1 mRNA

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

Ketoconazole results in decreased expression of AP1S1 mRNA

NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713

G

adaptor related protein complex 3 subunit mu 1

decreases expression

Ketoconazole results in decreased expression of AP3M1 mRNA

NCBI chr15:3,246,616...3,264,846
Ensembl chr15:3,246,926...3,264,844

G

apoptotic peptidase activating factor 1

decreases expression

Ketoconazole results in decreased expression of APAF1 mRNA

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

apolipoprotein A1

increases expression

Ketoconazole results in increased expression of APOA1 mRNA

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein A4

affects expression

Ketoconazole affects the expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein E

increases expression

Ketoconazole results in increased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

androgen receptor

multiple interactions
decreases expression
increases activity
decreases activity

[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of AR protein; Ketoconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; Ketoconazole inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein]
Ketoconazole results in decreased expression of AR protein
Ketoconazole results in increased activity of AR protein
Ketoconazole results in decreased activity of AR protein

PMID:11118046 PMID:18324785 PMID:19226368 PMID:19587329 PMID:24323034 More...

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

arginase 1

increases expression

Ketoconazole results in increased expression of ARG1 mRNA

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

ankyrin repeat and SOCS box-containing 17

increases expression

Ketoconazole results in increased expression of ASB17 mRNA

NCBI chr 2:242,775,887...242,786,950
Ensembl chr 2:242,775,994...242,786,903

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

Ketoconazole results in increased expression of ASNS mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

argininosuccinate synthase 1

increases expression

Ketoconazole results in increased expression of ASS1 mRNA

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

ATPase family, AAA domain containing 2

increases expression

Ketoconazole results in increased expression of ATAD2 mRNA

NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738

G

activating transcription factor 1

multiple interactions

Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]

NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670

G

ATP synthase membrane subunit c locus 2

increases expression

Ketoconazole results in increased expression of ATP5MC2 mRNA

NCBI chr 7:133,791,341...133,799,713
Ensembl chr 7:133,791,342...133,799,733

G

ATP synthase peripheral stalk subunit OSCP

increases expression

Ketoconazole results in increased expression of ATP5PO mRNA

NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592

G

ATPase H+ transporting V1 subunit D

increases expression

Ketoconazole results in increased expression of ATP6V1D mRNA

NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303

G

arginine vasopressin

increases expression

Ketoconazole results in increased expression of AVP mRNA

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

beta-secretase 1

decreases expression

Ketoconazole results in decreased expression of BACE1 mRNA

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BCL2-associated agonist of cell death

increases expression

Ketoconazole results in increased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; Ketoconazole inhibits the reaction [Calcifediol results in decreased expression of BAX mRNA]

PMID:21542014 PMID:31629065

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of BCL2 mRNA]

PMID:21542014 PMID:31629065

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 11

increases expression

Ketoconazole results in increased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

beclin 1

increases expression

Ketoconazole results in increased expression of BECN1 mRNA

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

betaine-homocysteine S-methyltransferase

affects expression

Ketoconazole affects the expression of BHMT mRNA

NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742

G

BicC family RNA binding protein 1

decreases expression

Ketoconazole results in decreased expression of BICC1 mRNA

NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776

G

BH3 interacting domain death agonist

increases expression

Ketoconazole results in increased expression of BID mRNA

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

bridging integrator 1

increases expression

Ketoconazole results in increased expression of BIN1 mRNA

NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263

G

baculoviral IAP repeat-containing 5

increases expression

Ketoconazole results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein 2

multiple interactions

Ketoconazole inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

bone morphogenetic protein 4

decreases expression

Ketoconazole results in decreased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

bone morphogenetic protein 6

increases expression

Ketoconazole results in increased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

basonuclin zinc finger protein 1

decreases expression

Ketoconazole results in decreased expression of BNC1 mRNA

NCBI chr 1:135,917,676...135,943,333
Ensembl chr 1:135,917,687...135,943,333

G

BCL2 interacting protein 1

increases expression

Ketoconazole results in increased expression of BNIP1 mRNA

NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157

G

BCL2 interacting protein 2

increases expression

Ketoconazole results in increased expression of BNIP2 mRNA

NCBI chr 8:70,640,436...70,661,782
Ensembl chr 8:70,640,445...70,675,590

G

BCL2 interacting protein 3

increases expression

Ketoconazole results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BCL2 interacting protein 3 like

decreases expression

Ketoconazole results in decreased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

similar to human chromosome 5 open reading frame 15

increases expression

Ketoconazole results in increased expression of C5ORF15 mRNA

NCBI chr10:36,563,989...36,576,593
Ensembl chr10:36,563,958...36,576,590

G

core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1

decreases expression

Ketoconazole results in decreased expression of C1GALT1 mRNA

NCBI chr 4:35,930,981...35,966,100
Ensembl chr 4:35,928,104...35,961,831

G

C1GALT1-specific chaperone 1

decreases expression

Ketoconazole results in decreased expression of C1GALT1C1 mRNA

NCBI chr X:117,378,123...117,382,620
Ensembl chr X:117,375,525...117,382,787

G

complement C3

increases expression

Ketoconazole results in increased expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

similar to human chromosome 1 open reading frame 174

increases expression

Ketoconazole results in increased expression of C1ORF174 mRNA

NCBI chr 5:164,515,578...164,520,022
Ensembl chr 5:164,515,559...164,520,021

G

calcium voltage-gated channel subunit alpha1 H

decreases expression

Ketoconazole results in decreased expression of CACNA1H mRNA

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

G

calcium voltage-gated channel subunit alpha1 I

decreases expression

Ketoconazole results in decreased expression of CACNA1I mRNA

NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688

G

calcium voltage-gated channel auxiliary subunit alpha2delta 3

increases expression

Ketoconazole results in increased expression of CACNA2D3 mRNA

NCBI chr16:4,098,439...4,912,498
Ensembl chr16:4,098,445...4,912,351

G

calcium voltage-gated channel auxiliary subunit alpha2delta 4

increases expression

Ketoconazole results in increased expression of CACNA2D4 mRNA

NCBI chr 4:152,408,588...152,521,478
Ensembl chr 4:152,408,657...152,521,268

G

calcium voltage-gated channel auxiliary subunit beta 1

decreases expression

Ketoconazole results in decreased expression of CACNB1 mRNA

NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694

G

calcium voltage-gated channel auxiliary subunit gamma 3

increases expression

Ketoconazole results in increased expression of CACNG3 mRNA

NCBI chr 1:177,201,361...177,297,019
Ensembl chr 1:177,201,288...177,297,024

G

calcium voltage-gated channel auxiliary subunit gamma 4

decreases expression

Ketoconazole results in decreased expression of CACNG4 mRNA

NCBI chr10:92,683,778...92,745,842
Ensembl chr10:92,683,761...92,746,126

G

calbindin 1

decreases expression

Ketoconazole results in decreased expression of CALB1 mRNA

NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431

G

calbindin 2

decreases expression

Ketoconazole results in decreased expression of CALB2 mRNA

NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438

G

cyclase associated actin cytoskeleton regulatory protein 1

increases expression

Ketoconazole results in increased expression of CAP1 mRNA

NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769

G

carbonic anhydrase 2

increases expression

Ketoconazole results in increased expression of CA2 mRNA; Ketoconazole results in increased expression of CAR2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

capping protein regulator and myosin 1 linker 1

decreases expression

Ketoconazole results in decreased expression of CARMIL1 mRNA

NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326

G

caspase 12

increases expression

Ketoconazole results in increased expression of CASP12 mRNA

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

increases activity
multiple interactions

Ketoconazole results in increased activity of CASP3 protein
Ketoconazole inhibits the reaction [Galactosamine results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Ketoconazole results in increased activity of CASP3 protein]

PMID:17936189 PMID:19631732

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

decreases expression
increases expression

Ketoconazole results in decreased expression of CASP6 mRNA
Ketoconazole results in increased expression of CASP6 mRNA

PMID:25787151 PMID:25808816

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

increases expression

Ketoconazole results in increased expression of CASP7 mRNA

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8 associated protein 2

affects expression

Ketoconazole affects the expression of CASP8AP2 mRNA

NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275

G

caspase 9

increases expression

Ketoconazole results in increased expression of CASP9 mRNA

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases expression

Ketoconazole results in decreased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

increases expression

Ketoconazole results in increased expression of CAV1 mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

chromobox 7

increases expression

Ketoconazole results in increased expression of CBX7 mRNA

NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973

G

coiled-coil domain containing 8

increases expression

Ketoconazole results in increased expression of CCDC8 mRNA

NCBI chr 1:77,679,521...77,682,849
Ensembl chr 1:77,679,218...77,683,090

G

cholecystokinin

increases expression

Ketoconazole results in increased expression of CCK mRNA

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]
Ketoconazole results in increased expression of CCL2 mRNA

PMID:16784723 PMID:37077353

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 27

multiple interactions

Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]

NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506

G

C-C motif chemokine ligand 5

multiple interactions
increases expression

Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
Ketoconazole results in increased expression of CCL5 mRNA

PMID:16784723 PMID:23688403 PMID:37077353

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 1

increases expression
affects expression

Ketoconazole results in increased expression of CCN1 mRNA
Ketoconazole affects the expression of CCN1 mRNA

PMID:36621641 PMID:36653537

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cyclin G1

increases expression

Ketoconazole results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

Cd200 molecule

increases expression

Ketoconazole results in increased expression of CD200 mRNA

NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648

G

Cd247 molecule

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr13:78,043,302...78,118,437
Ensembl chr13:78,043,307...78,122,263

G

CD274 molecule

decreases expression

Ketoconazole results in decreased expression of CD274 mRNA

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

Cd28 molecule

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

G

CD3 delta subunit of T-cell receptor complex

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809

G

CD3 epsilon subunit of T-cell receptor complex

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr 8:45,303,848...45,315,005
Ensembl chr 8:45,303,852...45,315,022

G

CD3 gamma subunit of T-cell receptor complex

multiple interactions

Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]

NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147

G

Cd47 molecule

increases expression

Ketoconazole results in increased expression of CD47 mRNA

NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425

G

CDC42 effector protein 2

decreases expression

Ketoconazole results in decreased expression of CDC42EP2 mRNA

NCBI chr 1:203,202,000...203,210,891
Ensembl chr 1:203,201,873...203,210,897

G

CDC42 effector protein 3

increases expression

Ketoconazole results in increased expression of CDC42EP3 mRNA

NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721

G

cyclin dependent kinase 2

decreases expression

Ketoconazole results in decreased expression of CDK2 mRNA

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 6

decreases expression

Ketoconazole results in decreased expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

increases expression

Ketoconazole results in increased expression of CDKN1A mRNA

PMID:16483768 PMID:25808816 PMID:37077353

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression

Ketoconazole results in increased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2C

affects expression

Ketoconazole affects the expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

CCAAT/enhancer binding protein alpha

increases expression

Ketoconazole results in increased expression of CEBPA mRNA

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

centromere protein U

decreases expression

Ketoconazole results in decreased expression of CENPU mRNA

NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823

G

centrosomal protein 15

increases expression

Ketoconazole results in increased expression of CEP15 mRNA

NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838

G

centrosomal protein 19

increases expression

Ketoconazole results in increased expression of CEP19 mRNA

NCBI chr11:68,677,869...68,687,117
Ensembl chr11:68,677,871...68,687,022

G

carboxylesterase 2H

affects expression

Ketoconazole affects the expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

complement factor B

increases expression

Ketoconazole results in increased expression of CFB mRNA

NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505

G

glycoprotein hormones, alpha polypeptide

decreases expression

Ketoconazole results in decreased expression of CGA mRNA

NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191

G

chromatin accessibility complex subunit 1

increases expression

Ketoconazole results in increased expression of CHRAC1 mRNA

NCBI chr 7:105,013,047...105,016,435
Ensembl chr 7:105,013,015...105,017,136

G

CBY1 interacting BAR domain containing 1

decreases expression

Ketoconazole results in decreased expression of CIBAR1 mRNA

NCBI chr 5:25,613,993...25,632,440
Ensembl chr 5:25,614,033...25,632,489

G

cell death-inducing DFFA-like effector a

increases expression

Ketoconazole results in increased expression of CIDEA mRNA

PMID:36653537 PMID:37077353

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

cytoskeleton associated protein 2-like

decreases expression

Ketoconazole results in decreased expression of CKAP2L mRNA

NCBI chr 3:116,497,186...116,524,302
Ensembl chr 3:116,498,022...116,524,366

G

cardiotrophin-like cytokine factor 1

increases expression

Ketoconazole results in increased expression of CLCF1 mRNA

NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605

G

C-type lectin domain family 4, member E

increases expression

Ketoconazole results in increased expression of CLEC4E mRNA

NCBI chr 4:156,606,927...156,612,911
Ensembl chr 4:156,607,614...156,612,767

G

calmin

multiple interactions

Ketoconazole promotes the reaction [Calcitriol results in increased expression of CLMN mRNA]

NCBI chr 6:123,707,710...123,807,283
Ensembl chr 6:123,713,507...123,807,272

G

CLN5, intracellular trafficking protein

affects expression

Ketoconazole affects the expression of CLN5 mRNA

NCBI chr15:79,893,573...79,903,438
Ensembl chr15:79,893,548...79,903,438

G

clusterin

affects expression
decreases expression

Ketoconazole affects the expression of CLU mRNA
Ketoconazole results in decreased expression of CLU mRNA

PMID:17558187 PMID:18289764

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

CKLF-like MARVEL transmembrane domain containing 6

affects expression

Ketoconazole affects the expression of CMTM6 mRNA

NCBI chr 8:114,422,934...114,441,034
Ensembl chr 8:114,422,921...114,441,033

G

CKLF-like MARVEL transmembrane domain containing 7

increases expression

Ketoconazole results in increased expression of CMTM7 mRNA

NCBI chr 8:114,448,037...114,474,958
Ensembl chr 8:114,448,042...114,474,621

G

cannabinoid receptor 2

decreases expression

Ketoconazole results in decreased expression of CNR2 mRNA

NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548

G

collagen type I alpha 1 chain

decreases expression

Ketoconazole results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

COMM domain containing 2

decreases expression

Ketoconazole results in decreased expression of COMMD2 mRNA

NCBI chr 2:141,848,661...141,852,907
Ensembl chr 2:141,848,680...141,852,888

G

COP1, E3 ubiquitin ligase

decreases expression

Ketoconazole results in decreased expression of COP1 mRNA

NCBI chr13:71,467,164...71,561,826
Ensembl chr13:71,429,961...71,538,890

G

COPI coat complex subunit zeta 1

decreases expression

Ketoconazole results in decreased expression of COPZ1 mRNA

NCBI chr 7:134,409,523...134,435,661
Ensembl chr 7:134,409,799...134,435,662

G

cytochrome c oxidase assembly factor COX18

affects expression

Ketoconazole affects the expression of COX18 mRNA

NCBI chr14:17,864,581...17,877,483
Ensembl chr14:17,865,857...17,877,480

G

carboxypeptidase N subunit 2

decreases expression

Ketoconazole results in decreased expression of CPN2 mRNA

NCBI chr11:70,486,054...70,495,937
Ensembl chr11:70,486,057...70,496,472

G

calcineurin-like phosphoesterase domain containing 1

affects expression

Ketoconazole affects the expression of CPPED1 mRNA

NCBI chr10:3,701,522...3,821,050
Ensembl chr10:3,701,459...3,821,054

G

carnitine palmitoyltransferase 1B

decreases expression

Ketoconazole results in decreased expression of CPT1B mRNA

NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404

G

carnitine palmitoyltransferase 2

increases expression

Ketoconazole results in increased expression of CPT2 mRNA

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

complement C3d receptor 2

increases expression

Ketoconazole results in increased expression of CR2 mRNA

NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235

G

cAMP responsive element binding protein 1

multiple interactions
decreases expression

Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]
Ketoconazole results in decreased expression of CREB1 mRNA
Ketoconazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of CREB1 protein]; Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]

PMID:12164941 PMID:17680988 PMID:37077353

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element modulator

affects expression
decreases expression

Ketoconazole affects the expression of CREM mRNA
Ketoconazole results in decreased expression of CREM mRNA

PMID:18355885 PMID:36653537

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

corticotropin releasing hormone receptor 2

decreases expression

Ketoconazole results in decreased expression of CRHR2 mRNA

NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904

G

cardiolipin synthase 1

increases expression

Ketoconazole results in increased expression of CRLS1 mRNA

NCBI chr 3:120,119,822...120,138,674
Ensembl chr 3:120,119,852...120,138,655

G

crystallin, mu

decreases expression

Ketoconazole results in decreased expression of CRYM mRNA

NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633

G

catenin beta 1

decreases expression

Ketoconazole results in decreased expression of CTNNB1 mRNA

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin L

decreases expression

Ketoconazole results in decreased expression of CTSL mRNA

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

cathepsin S

affects expression

Ketoconazole affects the expression of CTSS mRNA

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

C-X-C motif chemokine ligand 10

multiple interactions

Ketoconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Ketoconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 protein]

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 14

increases expression

Ketoconazole results in increased expression of CXCL14 mRNA

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

cytochrome b-245 alpha chain

increases expression

Ketoconazole results in increased expression of CYBA mRNA

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome c, somatic

decreases expression
increases expression

Ketoconazole results in decreased expression of CYCS mRNA
Ketoconazole results in increased expression of CYCS mRNA

PMID:25787151 PMID:37077353

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome c, testis

increases expression

Ketoconazole results in increased expression of CYCT mRNA

NCBI chr 3:61,290,090...61,297,158
Ensembl chr 3:60,913,562...61,297,158

G

cytochrome P450, family 11, subfamily a, polypeptide 1

increases expression

Ketoconazole results in increased expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 11, subfamily b, polypeptide 2

multiple interactions
decreases activity

Ketoconazole binds to and results in decreased activity of CYP11B1 protein
Ketoconazole results in decreased activity of CYP11B1 protein

PMID:15743198 PMID:31982514

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 11, subfamily b, polypeptide 3

decreases activity
multiple interactions
increases expression

Ketoconazole results in decreased activity of CYP11B2 protein
Ketoconazole binds to and results in decreased activity of CYP11B2 protein; Ketoconazole promotes the reaction [Colforsin results in increased expression of CYP11B2 mRNA]
Ketoconazole results in increased expression of CYP11B2 mRNA

PMID:15743198 PMID:16935330 PMID:31982514

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity
decreases expression
multiple interactions

Ketoconazole results in decreased activity of CYP17A1 protein
Ketoconazole results in decreased expression of CYP17A1 mRNA
Ketoconazole inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]

PMID:11118046 PMID:15743198 PMID:15771425 PMID:15934942 PMID:16935330 More...

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases activity
decreases expression
multiple interactions
decreases activity

Ketoconazole results in increased activity of CYP19A1 protein
Ketoconazole results in decreased expression of CYP19A1 mRNA
[Ketoconazole results in increased activity of CYP19A1 protein] which results in increased chemical synthesis of Estrone; [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased metabolism of Androstenedione
Ketoconazole results in decreased activity of CYP19A1 protein

PMID:20087668 PMID:27159630 PMID:31330226 PMID:36374910 PMID:36653537

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
increases expression
multiple interactions
decreases activity

Ketoconazole results in increased activity of CYP1A1 protein
Ketoconazole results in increased expression of CYP1A1 mRNA
Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 protein
Ketoconazole results in increased expression of CYP1A1 mRNA; Ketoconazole results in increased expression of CYP1A1 protein
Ketoconazole results in decreased activity of CYP1A1 protein
[Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of CYP1A1 mRNA]; Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 protein
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of CYP1A1 mRNA; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]

PMID:14709627 PMID:17283379 PMID:18420780 PMID:18493746 PMID:19070657 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression
decreases activity

Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines]
Ketoconazole results in increased expression of CYP1A2 mRNA; Ketoconazole results in increased expression of CYP1A2 protein
Ketoconazole results in decreased activity of CYP1A2 protein
Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin]
Ketoconazole inhibits the reaction [CYP1A2 protein results in increased oxidation of Uroporphyrinogens]

PMID:1567206 PMID:9305587 PMID:12814958 PMID:15618748 PMID:15879494 More...

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Ketoconazole results in decreased activity of CYP1B1 protein

PMID:14709627 PMID:18420780

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 24, subfamily a, polypeptide 1

multiple interactions
decreases activity

[Ketoconazole co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA; Ketoconazole inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein]
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]
[Ketoconazole results in decreased metabolism of alfacalcidol] which results in decreased expression of CYP24A1 mRNA; [Ketoconazole results in decreased metabolism of Calcitriol] which results in increased expression of CYP24A1 mRNA; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]
Ketoconazole results in decreased activity of CYP24A1 protein

PMID:16483768 PMID:16824767 PMID:18840526 PMID:20206692 PMID:26485663

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 26, subfamily a, polypeptide 1

decreases response to substance
increases expression
decreases activity
multiple interactions

Ketoconazole results in decreased susceptibility to CYP26A1 protein
Ketoconazole results in increased expression of CYP26A1 mRNA
Ketoconazole results in decreased activity of CYP26A1; Ketoconazole results in decreased activity of CYP26A1 protein
[[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-hydroxyretinoic acid; [[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-hydroxyretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-hydroxyretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNF protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNFSF10 protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of and results in decreased susceptibility to Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 results in increased metabolism of Tretinoin]

PMID:12091498 PMID:14532297 PMID:15703382 PMID:18059332 PMID:21906690 More...

NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204

G

cytochrome P450, family 26, subfamily b, polypeptide 1

multiple interactions
decreases activity

Ketoconazole inhibits the reaction [CYP26B1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26B1 results in increased metabolism of Tretinoin]
Ketoconazole results in decreased activity of CYP26B1

PMID:14532297 PMID:21906690

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

cytochrome P450, family 26, subfamily C, polypeptide 1

multiple interactions

Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of alitretinoin]; Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of Tretinoin]

NCBI chr 1:235,458,961...235,468,433
Ensembl chr 1:235,459,356...235,466,842

G

cytochrome P450, family 27, subfamily b, polypeptide 1

decreases activity

Ketoconazole results in decreased activity of CYP27B1 protein

NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241

G

cytochrome P450, family 2, subfamily a, polypeptide 1

affects expression
decreases activity
increases expression

Ketoconazole affects the expression of CYP2A1 mRNA
Ketoconazole results in decreased activity of CYP2A1 protein
Ketoconazole results in increased expression of CYP2A1 protein

PMID:7986207 PMID:15879494 PMID:18355885

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily a, polypeptide 2

multiple interactions

Ketoconazole inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline]

NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487

G

cytochrome P450, family 2, subfamily a, polypeptide 3

decreases activity

Ketoconazole results in decreased activity of CYP2A4 protein

NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

Ketoconazole inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin]

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 15

affects expression

Ketoconazole affects the expression of CYP2B15 mRNA

NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases activity
increases expression
multiple interactions

Ketoconazole results in decreased activity of CYP2B6 protein
Ketoconazole results in decreased activity of CYP2B10 protein
Ketoconazole results in increased expression of CYP2B10 mRNA
Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]

PMID:14709627 PMID:16608920 PMID:17438109 PMID:17966066 PMID:18420780

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions
decreases activity

Ketoconazole inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
Ketoconazole results in decreased activity of CYP2C11 protein

PMID:15879494 PMID:19858067

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
decreases activity

Ketoconazole inhibits the reaction [CYP2C6 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
Ketoconazole results in decreased activity of CYP2C29 protein
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
Ketoconazole results in decreased activity of CYP2C19 protein
Ketoconazole results in decreased activity of CYP2C6 protein

PMID:12814958 PMID:14709627 PMID:15618748 PMID:15879494 PMID:18420780 More...

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity
multiple interactions

Ketoconazole results in decreased activity of CYP2C8 protein
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]

PMID:14709627 PMID:15601807 PMID:24120545

G

cytochrome P450, family 2, subfamily d, polypeptide 2

multiple interactions

Ketoconazole inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]

NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
decreases expression
decreases activity

Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758]
Ketoconazole results in decreased expression of CYP2D22 mRNA; Ketoconazole results in decreased expression of CYP2D22 protein
Ketoconazole results in decreased activity of CYP2D22 protein; Ketoconazole results in decreased activity of CYP2D6 protein
Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan]; Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 mRNA]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 protein]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein]; Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]; Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 protein]

PMID:15618748 PMID:16595712 PMID:18420780 PMID:19230594 PMID:19594327 More...

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

Ketoconazole results in decreased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily j, polypeptide 4

decreases activity

Ketoconazole results in decreased activity of CYP2J2 protein

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases expression
increases response to substance
decreases activity
increases expression
increases metabolic processing

Ketoconazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of CYP3A2 protein]
Ketoconazole results in decreased expression of CYP3A4 mRNA; Ketoconazole results in decreased expression of CYP3A4 protein
CYP3A4 protein results in increased susceptibility to Ketoconazole
Ketoconazole results in decreased activity of CYP3A2 protein; Ketoconazole results in decreased activity of CYP3A4 protein
Ketoconazole results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased metabolism of Ketoconazole
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Testosterone; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Triazolam; Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole affects the reaction [CYP3A4 polymorphism affects the metabolism of cabozantinib]; Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of acalabrutinib]; Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of vandetanib]; Ketoconazole binds to and results in decreased activity of CYP3A4 protein; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with NADP] results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of Hydroxytestosterones]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Corticosterone results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Endosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Mefloquine]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased abundance of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of mono-N-demethyladinazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased susceptibility to Docetaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased abundance of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 11,12-epoxy-5,8,14-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 3'-p-hydroxypaclitaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of clozapine N-oxide]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of norclozapine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased glutathionylation of dauricine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Metoprolol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of mono-N-desethylamiodarone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of nefazodone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of 8-epidiosbulbin E acetate]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Arachidonic Acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufalin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufogenin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cabozantinib]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of carbosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cinobufagin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of eldecalcitol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Terfenadine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Triazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 2-oxo-clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of dimemorfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Paclitaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Endosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Ticlopidine]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [U 0126 affects the activity of CYP3A4 protein]; Ketoconazole results in increased expression of and results in decreased activity of CYP3A4 protein

PMID:9600717 PMID:10952769 PMID:10997946 PMID:11377097 PMID:11502731 More...

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions
decreases activity
affects expression

[Strychnine co-treated with Ketoconazole] results in decreased expression of CYP3A23-3A1 protein; Ketoconazole inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline]; Ketoconazole inhibits the reaction [Genistein results in increased expression of CYP3A23-3A1 mRNA]
Ketoconazole results in decreased activity of CYP3A23-3A1 protein
Ketoconazole affects the expression of CYP3A23-3A1 mRNA

PMID:12814958 PMID:15879494 PMID:18355885 PMID:19858067 PMID:32185415 More...

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions
affects response to substance
decreases activity

CYP3A5 gene polymorphism affects the reaction [Ketoconazole results in decreased metabolism of Tacrolimus]; Ketoconazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Budesonide results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A5 protein]; Ketoconazole inhibits the reaction [flunisolide results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Fluticasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA]
CYP3A5 gene polymorphism affects the susceptibility to Ketoconazole
Ketoconazole results in decreased activity of CYP3A5 protein

PMID:15557344 PMID:15731592 PMID:19384264 PMID:24555085 PMID:26302866 More...

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 4, subfamily b, polypeptide 1

increases expression

Ketoconazole results in increased expression of CYP4B1 mRNA

NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348

G

cytochrome P450, family 4, subfamily f, polypeptide 1

decreases activity

Ketoconazole results in decreased activity of CYP4F12 protein

NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046

G

cytochrome P450, family 4, subfamily f, polypeptide 4

affects expression

Ketoconazole affects the expression of CYP4F2 mRNA

NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506

G

cytochrome P450, family 51

decreases activity
increases expression
decreases response to substance
multiple interactions
increases activity

Ketoconazole results in decreased activity of CYP51A1 protein
Ketoconazole results in increased expression of CYP51 mRNA
CYP51A1 gene results in decreased susceptibility to Ketoconazole
[Ketoconazole results in increased activity of CYP51 protein] which results in increased abundance of Lanosterol
CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of Lanosterol]
Ketoconazole results in increased expression of CYP51 mRNA; Ketoconazole results in increased expression of CYP51 protein

PMID:12617470 PMID:16989930 PMID:17966066 PMID:18694951 PMID:28263823 More...

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions
increases expression

[Chenodeoxycholic Acid co-treated with Ketoconazole] results in decreased expression of CYP7A1 mRNA
Ketoconazole results in increased expression of CYP7A1 mRNA

PMID:30985903 PMID:31099283

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

DDB1 and CUL4 associated factor 8

affects expression

Ketoconazole affects the expression of DCAF8 mRNA

NCBI chr13:84,609,838...84,667,025
Ensembl chr13:84,610,248...84,669,726

G

dephospho-CoA kinase domain containing

increases expression

Ketoconazole results in increased expression of DCAKD mRNA

NCBI chr10:87,957,738...87,989,002
Ensembl chr10:87,957,740...87,980,054

G

damage-specific DNA binding protein 1

increases expression

Ketoconazole results in increased expression of DDB1 mRNA

NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676

G

DNA-damage inducible transcript 3

increases expression
affects expression
multiple interactions

Ketoconazole results in increased expression of DDIT3 mRNA
Ketoconazole affects the expression of DDIT3 mRNA
EIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA]

PMID:16330322 PMID:31099283 PMID:36621641

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEPP autophagy regulator 1

decreases expression
increases expression

Ketoconazole results in decreased expression of DEPP1 mRNA
Ketoconazole results in increased expression of DEPP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

desumoylating isopeptidase 2

decreases expression

Ketoconazole results in decreased expression of DESI2 mRNA

NCBI chr13:89,961,767...90,011,255
Ensembl chr13:89,961,934...90,016,416

G

diacylglycerol kinase, alpha

decreases expression

Ketoconazole results in decreased expression of DGKA mRNA

NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110

G

7-dehydrocholesterol reductase

increases expression

Ketoconazole results in increased expression of DHCR7 mRNA

PMID:28263823 PMID:36621641 PMID:36653537

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

dehydrogenase/reductase 3

increases expression

Ketoconazole results in increased expression of DHRS3 mRNA

NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417

G

DExH-box helicase 9

increases expression

Ketoconazole results in increased expression of DHX9 mRNA

NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069

G

dihydrolipoamide S-acetyltransferase

decreases expression

Ketoconazole results in decreased expression of DLAT mRNA

NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479

G

DLC1 Rho GTPase activating protein

decreases expression

Ketoconazole results in decreased expression of DLC1 mRNA

NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439

G

delta like non-canonical Notch ligand 1

decreases expression

Ketoconazole results in decreased expression of DLK1 mRNA

NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522

G

DNA meiotic recombinase 1

increases expression

Ketoconazole results in increased expression of DMC1 mRNA

NCBI chr 7:111,124,888...111,167,465
Ensembl chr 7:111,124,888...111,167,952

G

Dmx-like 1

decreases expression

Ketoconazole results in decreased expression of DMXL1 mRNA

NCBI chr18:42,993,292...43,163,457
Ensembl chr18:42,993,340...43,163,456

G

deoxyribonuclease 1-like 1

decreases expression

Ketoconazole results in decreased expression of DNASE1L1 mRNA

NCBI chr X:152,056,942...152,065,518
Ensembl chr X:152,056,942...152,065,518

G

DNA methyltransferase 3 alpha

increases expression
decreases expression

Ketoconazole results in increased expression of DNMT3A mRNA
Ketoconazole results in decreased expression of DNMT3A mRNA

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

DNA methyltransferase 3 beta

decreases expression

Ketoconazole results in decreased expression of DNMT3B mRNA

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

dedicator of cyto-kinesis 1

decreases expression

Ketoconazole results in decreased expression of DOCK1 mRNA

NCBI chr 1:189,467,143...189,983,777
Ensembl chr 1:189,467,143...189,983,768

G

dedicator of cytokinesis 6

increases expression

Ketoconazole results in increased expression of DOCK6 mRNA

NCBI chr 8:20,342,430...20,394,660
Ensembl chr 8:20,342,089...20,394,552

G

docking protein 7

decreases expression

Ketoconazole results in decreased expression of DOK7 mRNA

NCBI chr14:75,665,444...75,699,413
Ensembl chr14:75,666,744...75,699,386

G

deleted in primary ciliary dyskinesia

increases expression

Ketoconazole results in increased expression of DPCD mRNA

NCBI chr 1:244,408,766...244,426,891
Ensembl chr 1:244,408,785...244,426,888

G

dopamine receptor D4

decreases expression
multiple interactions

Ketoconazole results in decreased expression of DRD4 mRNA
Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of DRD4 mRNA]

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

drosha ribonuclease III

decreases expression

Ketoconazole results in decreased expression of DROSHA mRNA

NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688

G

dual specificity phosphatase 1

increases expression

Ketoconazole results in increased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

endothelin receptor type B

increases expression

Ketoconazole results in increased expression of EDNRB mRNA

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

epidermal growth factor

increases uptake
multiple interactions

Ketoconazole results in increased uptake of EGF protein
Ketoconazole inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions
decreases expression

Ketoconazole inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein]
Ketoconazole results in decreased expression of EGFR mRNA

PMID:23125191 PMID:37077353

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 1

increases expression

Ketoconazole results in increased expression of EGLN1 mRNA

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

egl-9 family hypoxia-inducible factor 3

increases expression

Ketoconazole results in increased expression of EGLN3 mRNA

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

eukaryotic translation initiation factor 1A domain containing

increases expression

Ketoconazole results in increased expression of EIF1AD mRNA

NCBI chr 1:202,674,362...202,679,662
Ensembl chr 1:202,674,185...202,679,658

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Ketoconazole inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

EIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA]; EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA]; EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA]

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 3 subunit E

decreases expression

Ketoconazole results in decreased expression of EIF3E mRNA

NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096

G

eukaryotic translation initiation factor 3, subunit M

increases expression

Ketoconazole results in increased expression of EIF3M mRNA

NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392

G

eukaryotic translation initiation factor 4B

affects expression

Ketoconazole affects the expression of EIF4B mRNA

NCBI chr 7:133,206,637...133,228,436

G

eukaryotic translation initiation factor 4E binding protein 1

increases expression

Ketoconazole results in increased expression of EIF4EBP1 mRNA

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

elaC ribonuclease Z 1

increases expression

Ketoconazole results in increased expression of ELAC1 mRNA

NCBI chr18:67,321,231...67,341,358
Ensembl chr18:67,323,583...67,340,936

G

ELOVL fatty acid elongase 5

decreases expression

Ketoconazole results in decreased expression of ELOVL5 mRNA

NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284

G

ELOVL fatty acid elongase 6

decreases expression

Ketoconazole results in decreased expression of ELOVL6 mRNA

NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186

G

ectonucleotide pyrophosphatase/phosphodiesterase 3

decreases expression

Ketoconazole results in decreased expression of ENPP3 mRNA

NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041

G

endothelial PAS domain protein 1

increases expression

Ketoconazole results in increased expression of EPAS1 mRNA

PMID:36621641 PMID:37077353

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

erythrocyte membrane protein band 4.1-like 3

decreases expression

Ketoconazole results in decreased expression of EPB41L3 mRNA

NCBI chr 9:109,056,178...109,260,607
Ensembl chr 9:109,016,113...109,260,607

G

epoxide hydrolase 1

affects expression
increases expression

Ketoconazole affects the expression of EPHX1 mRNA
Ketoconazole results in increased expression of EPHX1 mRNA

PMID:18355885 PMID:37077353

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

erythropoietin

multiple interactions

Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

epididymal peptidase inhibitor

multiple interactions
decreases expression

Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of EPPIN mRNA]

NCBI chr 3:153,312,396...153,319,310
Ensembl chr 3:153,312,396...153,319,310

G

Era-like 12S mitochondrial rRNA chaperone 1

decreases expression

Ketoconazole results in decreased expression of ERAL1 mRNA

NCBI chr10:62,961,725...62,968,747
Ensembl chr10:62,961,730...62,968,994

G

ELKS/RAB6-interacting/CAST family member 1

decreases expression

Ketoconazole results in decreased expression of ERC1 mRNA

NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639

G

epiregulin

increases expression

Ketoconazole results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

endoplasmic reticulum oxidoreductase 1 alpha

decreases expression

Ketoconazole results in decreased expression of ERO1A mRNA

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

G

endoplasmic reticulum protein 29

affects expression

Ketoconazole affects the expression of ERP29 mRNA

NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376

G

establishment of sister chromatid cohesion N-acetyltransferase 2

decreases expression

Ketoconazole results in decreased expression of ESCO2 mRNA

NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306

G

estrogen receptor 1

decreases expression

Ketoconazole results in decreased expression of ESR1 mRNA

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen related receptor, alpha

increases expression

Ketoconazole results in increased expression of ESRRA mRNA

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

ETS proto-oncogene 1, transcription factor

decreases expression

Ketoconazole results in decreased expression of ETS1 mRNA

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

exocyst complex component 6B

increases expression

Ketoconazole results in increased expression of EXOC6B mRNA

NCBI chr 4:117,094,741...117,550,221
Ensembl chr 4:117,094,741...117,550,180

G

enhancer of zeste 1 polycomb repressive complex 2 subunit

increases expression

Ketoconazole results in increased expression of EZH1 mRNA

NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

decreases expression

Ketoconazole results in decreased expression of EZH2 mRNA

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

coagulation factor III, tissue factor

increases expression

Ketoconazole results in increased expression of F3 protein

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid binding protein 1

increases expression

Ketoconazole results in increased expression of FABP1 mRNA

PMID:15342952 PMID:17175557 PMID:17567588 PMID:36653537

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

fatty acid binding protein 3

increases expression

Ketoconazole results in increased expression of FABP3 mRNA

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

fatty acid binding protein 4

increases expression

Ketoconazole results in increased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid binding protein 5

increases expression

Ketoconazole results in increased expression of FABP5 mRNA

PMID:31099283 PMID:37077353

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

G

Fas associated factor 1

increases expression

Ketoconazole results in increased expression of FAF1 mRNA

NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977

G

FAM20C, golgi associated secretory pathway kinase

increases expression

Ketoconazole results in increased expression of FAM20C mRNA

NCBI chr12:15,826,864...15,885,423
Ensembl chr12:15,826,871...15,884,543

G

Fas cell surface death receptor

increases expression
multiple interactions

Ketoconazole results in increased expression of FAS mRNA
Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]

PMID:15703382 PMID:25808816

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

F-box and leucine-rich repeat protein 14

decreases expression

Ketoconazole results in decreased expression of FBXL14 mRNA

NCBI chr 4:152,662,542...152,666,360
Ensembl chr 4:152,662,542...152,666,360

G

F-box and leucine-rich repeat protein 15

decreases expression

Ketoconazole results in decreased expression of FBXL15 mRNA

NCBI chr 1:245,189,732...245,191,973
Ensembl chr 1:245,189,736...245,192,007

G

F-box protein 21

increases expression

Ketoconazole results in increased expression of FBXO21 mRNA

NCBI chr12:38,570,878...38,605,133
Ensembl chr12:38,571,023...38,605,133

G

F-box and WD repeat domain containing 2

increases expression

Ketoconazole results in increased expression of FBXW2 mRNA

NCBI chr 3:18,088,859...18,114,387
Ensembl chr 3:18,088,865...18,114,381

G

farnesyl diphosphate farnesyl transferase 1

increases expression

Ketoconazole results in increased expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

farnesyl diphosphate synthase

increases expression

Ketoconazole results in increased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

ferredoxin 1

decreases expression

Ketoconazole results in decreased expression of FDX1 mRNA

NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414

G

Fez family zinc finger 1

decreases expression

Ketoconazole results in decreased expression of FEZF1 mRNA

NCBI chr 4:51,762,751...51,766,078
Ensembl chr 4:51,762,751...51,766,078

G

fibroblast growth factor binding protein 3

increases expression

Ketoconazole results in increased expression of FGFBP3 mRNA

NCBI chr 1:234,644,023...234,646,028
Ensembl chr 1:234,644,019...234,646,547

G

flavin adenine dinucleotide synthetase 1

decreases expression

Ketoconazole results in decreased expression of FLAD1 mRNA

NCBI chr 2:174,819,451...174,828,921
Ensembl chr 2:174,819,453...174,828,977

G

fibronectin 1

decreases expression

Ketoconazole results in decreased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

fibronectin type III domain containing 4

increases expression

Ketoconazole results in increased expression of FNDC4 mRNA

PMID:15342952 PMID:17175557 PMID:17567588

NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675

G

FOS like 1, AP-1 transcription factor subunit

decreases expression
increases expression

Ketoconazole results in decreased expression of FOSL1 mRNA
Ketoconazole results in increased expression of FOSL1 mRNA

PMID:25787151 PMID:31099283

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box A2

increases expression

Ketoconazole results in increased expression of FOXA2 mRNA

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326

G

forkhead box L2

increases expression

Ketoconazole results in increased expression of FOXL2 mRNA

NCBI chr 8:99,512,971...99,514,500
Ensembl chr 8:99,513,303...99,514,427

G

forkhead box P2

increases expression

Ketoconazole results in increased expression of FOXP2 mRNA

NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683

G

fascin actin-bundling protein 1

decreases expression

Ketoconazole results in decreased expression of FSCN1 mRNA

NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211

G

follicle stimulating hormone subunit beta

multiple interactions

Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of GPD1 mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of RHOX5 mRNA]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

FYVE and coiled-coil domain autophagy adaptor 1

increases expression
decreases expression

Ketoconazole results in increased expression of FYCO1 mRNA
Ketoconazole results in decreased expression of FYCO1 mRNA

PMID:36621641 PMID:36653537

NCBI chr 8:123,412,105...123,479,315
Ensembl chr 8:123,412,112...123,479,021

G

G0/G1switch 2

decreases expression

Ketoconazole results in decreased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

glucose-6-phosphatase catalytic subunit 1

affects expression

Ketoconazole affects the expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

increases expression

Ketoconazole results in increased expression of G6PD mRNA

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

GABA type A receptor associated protein like 2

increases expression

Ketoconazole results in increased expression of GABARAPL2 mRNA

NCBI chr19:39,910,572...39,921,408
Ensembl chr19:39,910,534...39,924,628
Ensembl chr 8:39,910,534...39,924,628

G

gamma-aminobutyric acid type B receptor subunit 1

increases expression

Ketoconazole results in increased expression of GABBR1 mRNA

NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994

G

gamma-aminobutyric acid type B receptor subunit 2

increases expression

Ketoconazole results in increased expression of GABBR2 mRNA

NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104

G

gamma-aminobutyric acid type A receptor subunit alpha 4

increases expression

Ketoconazole results in increased expression of GABRA4 mRNA

NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844

G

gamma-aminobutyric acid type A receptor subunit alpha 5

decreases expression

Ketoconazole results in decreased expression of GABRA5 mRNA

NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917

G

gamma-aminobutyric acid type A receptor subunit delta

increases expression

Ketoconazole results in increased expression of GABRD mRNA

NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411

G

gamma-aminobutyric acid type A receptor subunit epsilon

decreases expression

Ketoconazole results in decreased expression of GABRE mRNA

NCBI chr X:150,060,035...150,078,773
Ensembl chr X:150,060,040...150,078,693

G

gamma-aminobutyric acid type A receptor subunit theta

decreases expression

Ketoconazole results in decreased expression of GABRQ mRNA

NCBI chr X:150,696,161...150,712,948
Ensembl chr X:150,696,427...150,709,919

G

glutamate decarboxylase 1

decreases expression

Ketoconazole results in decreased expression of GAD1 mRNA

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

growth arrest and DNA-damage-inducible, alpha

increases expression

Ketoconazole results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

Ketoconazole results in increased expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

GATA binding protein 3

increases expression

Ketoconazole results in increased expression of GATA3 mRNA

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

glucokinase

decreases expression

Ketoconazole results in decreased expression of GCK mRNA

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

glucokinase regulator

affects expression

Ketoconazole affects the expression of GCKR mRNA

NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654

G

GDP dissociation inhibitor 2

increases expression

Ketoconazole results in increased expression of GDI2 mRNA

NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366

G

glycerophosphodiester phosphodiesterase domain containing 3

increases expression

Ketoconazole results in increased expression of GDPD3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063

G

GDP-L-fucose synthase

increases expression

Ketoconazole results in increased expression of GFUS mRNA

NCBI chr 7:107,612,087...107,617,005
Ensembl chr 7:107,612,094...107,616,948

G

growth hormone receptor

decreases expression

Ketoconazole results in decreased expression of GHR mRNA

NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735

G

gap junction protein, beta 1

decreases expression

Ketoconazole results in decreased expression of GJB1 mRNA

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

gap junction protein, beta 2

increases expression

Ketoconazole results in increased expression of GJB2 mRNA

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

glutaminase 2

affects expression

Ketoconazole affects the expression of GLS2 mRNA

NCBI chr 7:617,252...633,424
Ensembl chr 7:617,288...633,426

G

G protein subunit alpha i1

increases expression

Ketoconazole results in increased expression of GNAI1 mRNA

NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417

G

G protein subunit gamma 11

decreases expression

Ketoconazole results in decreased expression of GNG11 mRNA

NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442

G

G protein nucleolar 3

decreases expression

Ketoconazole results in decreased expression of GNL3 mRNA

NCBI chr16:6,207,402...6,213,491
Ensembl chr16:6,207,402...6,213,392

G

gonadotropin releasing hormone 1

affects secretion

Ketoconazole affects the secretion of GNRH1 protein

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

golgin A3

decreases expression

Ketoconazole results in decreased expression of GOLGA3 mRNA

NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509

G

golgi membrane protein 1

decreases expression

Ketoconazole results in decreased expression of GOLM1 mRNA

NCBI chr17:4,995,925...5,044,329
Ensembl chr17:4,996,104...5,034,057

G

golgi phosphoprotein 3-like

decreases expression

Ketoconazole results in decreased expression of GOLPH3L mRNA

NCBI chr 2:183,151,941...183,183,094
Ensembl chr 2:183,153,301...183,183,083

G

glutamic-oxaloacetic transaminase 1

increases expression

Ketoconazole results in increased expression of GOT1 protein

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic-oxaloacetic transaminase 2

affects expression

Ketoconazole affects the expression of GOT2 mRNA

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

glycerol-3-phosphate acyltransferase, mitochondrial

decreases expression

Ketoconazole results in decreased expression of GPAM mRNA

NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639

G

G patch domain containing 2

increases expression

Ketoconazole results in increased expression of GPATCH2 mRNA

NCBI chr13:98,784,993...98,925,696
Ensembl chr13:98,784,969...98,925,661

G

glycerol-3-phosphate dehydrogenase 1

multiple interactions
increases expression
decreases expression

Ketoconazole inhibits the reaction [FSHB protein results in increased expression of GPD1 mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of GPD1 mRNA]
Ketoconazole results in increased expression of GPD1 mRNA

PMID:19587329 PMID:37077353

NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529

G

G protein-coupled receptor 12

increases expression

Ketoconazole results in increased expression of GPR12 mRNA

NCBI chr12:8,522,709...8,525,875
Ensembl chr12:8,522,953...8,527,973

G

G protein-coupled receptor 17

decreases expression
increases expression

Ketoconazole results in decreased expression of GPR17 mRNA
Ketoconazole results in increased expression of GPR17 mRNA

NCBI chr18:23,576,232...23,583,153
Ensembl chr18:23,577,242...23,582,966

G

G protein-coupled receptor 37

increases expression

Ketoconazole results in increased expression of GPR37 mRNA

NCBI chr 4:54,138,860...54,160,927
Ensembl chr 4:54,138,870...54,161,001

G

G protein-coupled receptor 6

decreases expression

Ketoconazole results in decreased expression of GPR6 mRNA

NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624

G

glutamic--pyruvic transaminase

multiple interactions
increases expression

Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
Ketoconazole results in increased expression of GPT protein
Ketoconazole inhibits the reaction [columbin results in increased activity of GPT protein]; Ketoconazole promotes the reaction [gelsemine results in increased expression of GPT protein]

PMID:31099283 PMID:31168027 PMID:32162908 PMID:34627953

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 4

increases expression

Ketoconazole results in increased expression of GPX4 mRNA

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

growth factor receptor bound protein 14

affects expression

Ketoconazole affects the expression of GRB14 mRNA

NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889

G

growth regulating estrogen receptor binding 1

increases expression

Ketoconazole results in increased expression of GREB1 mRNA

NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633

G

Grid2 interacting protein

increases expression

Ketoconazole results in increased expression of GRID2IP mRNA

NCBI chr12:11,166,567...11,203,765
Ensembl chr12:11,167,874...11,203,676

G

glutamate ionotropic receptor kainate type subunit 2

decreases expression

Ketoconazole results in decreased expression of GRIK2 mRNA

NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

increases expression

Ketoconazole results in increased expression of GRINA mRNA

NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366

G

glutamate metabotropic receptor 3

increases expression

Ketoconazole results in increased expression of GRM3 mRNA

NCBI chr 4:24,364,854...24,643,972
Ensembl chr 4:24,365,115...24,609,804

G

glutamate metabotropic receptor 4

affects expression

Ketoconazole affects the expression of GRM4 mRNA

NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821

G

glutathione-disulfide reductase

increases expression
multiple interactions

Ketoconazole results in increased expression of GSR mRNA
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 1

multiple interactions
decreases expression

Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of GSTA1 mRNA]
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Genistein results in increased expression of GSTA1 mRNA]
Ketoconazole results in decreased expression of GSTA1 mRNA

PMID:16608920 PMID:31168027 PMID:32185415

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 2

decreases expression

Ketoconazole results in decreased expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase mu 1

increases expression

Ketoconazole results in increased expression of GSTM1 protein

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

affects expression

Ketoconazole affects the expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

multiple interactions

Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

GTP binding protein 8

decreases expression

Ketoconazole results in decreased expression of GTPBP8 mRNA

NCBI chr11:55,945,778...55,955,743
Ensembl chr11:55,945,795...55,955,635

G

GDNF-inducible zinc finger protein 1

increases expression

Ketoconazole results in increased expression of GZF1 mRNA

NCBI chr 3:136,119,004...136,131,223
Ensembl chr 3:136,119,113...136,131,223

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

decreases expression
increases expression

Ketoconazole results in decreased expression of H6PD mRNA
Ketoconazole results in increased expression of H6PD mRNA

PMID:36621641 PMID:37077353

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

increases expression
decreases expression

Ketoconazole results in increased expression of HADHA mRNA
Ketoconazole results in decreased expression of HADHA mRNA

PMID:36621641 PMID:37077353

NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

Ketoconazole results in increased expression of HADHB mRNA

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

histidine ammonia lyase

affects expression

Ketoconazole affects the expression of HAL mRNA

NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701

G

hepcidin antimicrobial peptide

multiple interactions
decreases expression

Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Ketoconazole results in decreased expression of HAMP protein

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

hyaluronan synthase 2

increases expression

Ketoconazole results in increased expression of HAS2 mRNA

NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933

G

hepatitis A virus cellular receptor 1

decreases expression

Ketoconazole results in decreased expression of HAVCR1 mRNA

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

hemoglobin subunit beta

decreases expression

Ketoconazole results in decreased expression of HBB mRNA; Ketoconazole results in decreased expression of HBB-B1 mRNA

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

heme binding protein 1

increases expression

Ketoconazole results in increased expression of HEBP1 mRNA

NCBI chr 4:167,974,316...168,003,854
Ensembl chr 4:167,974,319...168,003,854

G

hes family bHLH transcription factor 6

decreases expression

Ketoconazole results in decreased expression of HES6 mRNA

NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559

G

3-hydroxyisobutyrate dehydrogenase

increases expression

Ketoconazole results in increased expression of HIBADH mRNA

NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617

G

hypoxia inducible factor 1 subunit alpha inhibitor

increases expression

Ketoconazole results in increased expression of HIF1AN mRNA

NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327

G

histone cluster 1 H4 family member B

decreases expression

Ketoconazole results in decreased expression of HIST1H4B mRNA

NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370

G

HIVEP zinc finger 1

increases expression

Ketoconazole results in increased expression of HIVEP1 mRNA

NCBI chr17:22,585,016...22,714,517
Ensembl chr17:22,585,016...22,711,956

G

high mobility group AT-hook 2

increases expression

Ketoconazole results in increased expression of HMGA2 mRNA

NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784

G

high mobility group box 2

affects expression

Ketoconazole affects the expression of HMGB2 mRNA

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases activity
decreases expression
increases expression
decreases activity
multiple interactions

Ketoconazole results in increased activity of HMGCR protein
Ketoconazole results in decreased expression of HMGCR mRNA
Ketoconazole results in increased expression of HMGCR mRNA
Ketoconazole results in decreased activity of HMGCR protein
[Colforsin co-treated with Ketoconazole] results in decreased expression of HMGCR mRNA

PMID:9199277 PMID:12617470 PMID:16935330 PMID:28263823 PMID:37077353

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

Ketoconazole results in increased expression of HMGCS1 mRNA

PMID:28263823 PMID:31099283

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

decreases expression

Ketoconazole results in decreased expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

heme oxygenase 1

affects expression
increases expression
multiple interactions

Ketoconazole affects the expression of HMOX1 mRNA
Ketoconazole results in increased expression of HMOX1 mRNA
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Ketoconazole inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]

PMID:12763371 PMID:18289764 PMID:22659318 PMID:31168027 PMID:37077353

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

HORMA domain containing 1

increases expression

Ketoconazole results in increased expression of HORMAD1 mRNA

NCBI chr 2:183,115,815...183,152,383
Ensembl chr 2:183,116,716...183,152,383

G

homeo box A4

decreases expression

Ketoconazole results in decreased expression of HOXA4 mRNA

NCBI chr 4:81,289,677...81,291,685
Ensembl chr 4:81,289,682...81,291,685

G

hepsin

increases expression

Ketoconazole results in increased expression of HPN mRNA

NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811

G

HRas proto-oncogene, GTPase

decreases expression

Ketoconazole results in decreased expression of HRAS mRNA

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity

Ketoconazole results in decreased activity of HSD11B2 protein

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

hydroxysteroid (17-beta) dehydrogenase 2

multiple interactions

Ketoconazole promotes the reaction [Calcitriol results in increased expression of HSD17B2 mRNA]

NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202

G

hydroxysteroid (17-beta) dehydrogenase 4

multiple interactions
increases expression

Ketoconazole promotes the reaction [Colforsin results in increased expression of HSD17B4 mRNA]
Ketoconazole results in increased expression of HSD17B4 mRNA

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

hydroxysteroid (17-beta) dehydrogenase 7

increases expression

Ketoconazole results in increased expression of HSD17B7 mRNA

NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression

Ketoconazole results in decreased expression of HSD3B1 mRNA

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

multiple interactions
decreases expression

[Colforsin co-treated with Ketoconazole] results in decreased expression of HSD3B2 mRNA
Ketoconazole results in decreased expression of HSD3B2 mRNA

NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852

G

heat shock protein family D (Hsp60) member 1

decreases expression

Ketoconazole results in decreased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

hyaluronidase 2

increases expression

Ketoconazole results in increased expression of HYAL2 mRNA

NCBI chr 8:108,241,895...108,246,853
Ensembl chr 8:108,243,133...108,246,850

G

hyccin PI4KA lipid kinase complex subunit 1

decreases expression

Ketoconazole results in decreased expression of HYCC1 mRNA

NCBI chr 4:11,132,224...11,239,120
Ensembl chr 4:11,132,385...11,239,113

G

integrin-binding sialoprotein

multiple interactions

Ketoconazole inhibits the reaction [Calcifediol results in increased expression of IBSP mRNA]

NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693

G

inhibitor of DNA binding 4

increases expression

Ketoconazole results in increased expression of ID4 mRNA

NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470

G

isopentenyl-diphosphate delta isomerase 1

increases expression
multiple interactions

Ketoconazole results in increased expression of IDI1 mRNA
EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA]

PMID:16330322 PMID:28263823

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

interferon induced with helicase C domain 1

increases expression

Ketoconazole results in increased expression of IFIH1 mRNA

NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456

G

insulin-like growth factor binding protein 1

increases expression

Ketoconazole results in increased expression of IGFBP1 mRNA

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

insulin-like growth factor binding protein 5

increases expression

Ketoconazole results in increased expression of IGFBP5 mRNA

PMID:36653537 PMID:37077353

NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156

G

insulin-like growth factor binding protein 6

increases expression

Ketoconazole results in increased expression of IGFBP6 mRNA

NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966

G

insulin-like growth factor binding protein 7

increases expression

Ketoconazole results in increased expression of IGFBP7 mRNA

NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314

G

immunoglobulin heavy constant epsilon

multiple interactions

Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]

G

immunoglobulin kappa constant

decreases expression

Ketoconazole results in decreased expression of IGKC mRNA

G

immunoglobulin superfamily, member 10

decreases expression

Ketoconazole results in decreased expression of IGSF10 mRNA

NCBI chr 2:143,575,710...143,605,044
Ensembl chr 2:143,576,070...143,604,773

G

Indian hedgehog signaling molecule

increases expression

Ketoconazole results in increased expression of IHH mRNA

NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532

G

interleukin 1 alpha

increases expression

Ketoconazole results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression

Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]; Ketoconazole promotes the reaction [gelsemine results in increased expression of IL1B protein]
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]
Ketoconazole results in increased expression of IL1B mRNA

PMID:17966066 PMID:28138970 PMID:31168027 PMID:32816093 PMID:34627953

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

multiple interactions

Ketoconazole promotes the reaction [Calcitriol results in increased expression of IL1RL1 mRNA]

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 24

increases expression

Ketoconazole results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

interleukin 33

affects expression
increases expression

Ketoconazole affects the expression of IL33 mRNA
Ketoconazole results in increased expression of IL33 mRNA

PMID:18355885 PMID:37077353

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

interleukin 4

multiple interactions
decreases expression
decreases secretion

1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]]; Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Ketoconazole inhibits the reaction [IL4 protein results in increased chemical synthesis of Cyclic AMP]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]; Ketoconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]

PMID:11886533 PMID:12230500 PMID:15284827 PMID:23688403

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

multiple interactions
decreases secretion
decreases expression

1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]

PMID:11886533 PMID:15284827

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

multiple interactions

Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]; Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]

PMID:17966066 PMID:31168027

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibitor of growth family, member 1

decreases expression

Ketoconazole results in decreased expression of ING1 mRNA

NCBI chr16:77,937,276...77,945,320
Ensembl chr16:77,937,279...77,946,264

G

inhibitor of growth family, member 2

decreases expression

Ketoconazole results in decreased expression of ING2 mRNA

NCBI chr16:44,573,592...44,584,180
Ensembl chr16:44,575,597...44,583,482

G

inhibin subunit beta E

increases expression

Ketoconazole results in increased expression of INHBE mRNA

PMID:15342952 PMID:17175557 PMID:17567588

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

INTS3 and NABP interacting protein

increases expression

Ketoconazole results in increased expression of INIP mRNA

NCBI chr 5:74,648,392...74,662,628
Ensembl chr 5:74,648,392...74,662,628

G

insulin induced gene 1

increases expression

Ketoconazole results in increased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

insulin-like 3

decreases expression

Ketoconazole results in decreased expression of INSL3 mRNA

NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560

G

insulin receptor

decreases expression

Ketoconazole results in decreased expression of INSR mRNA

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

importin 5

decreases expression

Ketoconazole results in decreased expression of IPO5 mRNA

NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126

G

importin 7

increases expression

Ketoconazole results in increased expression of IPO7 mRNA

NCBI chr 1:164,062,702...164,102,938
Ensembl chr 1:164,062,702...164,102,938

G

insulin receptor substrate 1

decreases expression

Ketoconazole results in decreased expression of IRS1 mRNA

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

inositol 1,4,5-trisphosphate receptor, type 1

increases expression

Ketoconazole results in increased expression of ITPR1 mRNA

NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491

G

isovaleryl-CoA dehydrogenase

increases expression

Ketoconazole results in increased expression of IVD mRNA

NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575

G

potassium channel modulatory factor 1

increases expression

Ketoconazole results in increased expression of KCMF1 mRNA

NCBI chr 4:104,888,452...104,950,234
Ensembl chr 4:104,889,847...104,950,234

G

potassium voltage-gated channel subfamily A member 5

decreases activity

Ketoconazole results in decreased activity of KCNA5 protein

NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697

G

potassium voltage-gated channel subfamily E regulatory subunit 2

increases expression

Ketoconazole results in increased expression of KCNE2 mRNA

NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043

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potassium voltage-gated channel subfamily H member 1

decreases expression

Ketoconazole results in decreased expression of KCNH1 mRNA

NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740

G

potassium voltage-gated channel subfamily H member 2

affects activity
decreases response to substance
multiple interactions
decreases activity
affects localization

Ketoconazole affects the activity of KCNH2 protein mutant form
KCNH2 protein mutant form results in decreased susceptibility to Ketoconazole
[Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with Loratadine] results in decreased activity of KCNH2 protein; Ketoconazole binds to and results in decreased activity of KCNH2 protein; Terfenadine promotes the reaction [Ketoconazole results in decreased activity of KCNH2 protein]
Ketoconazole results in decreased activity of KCNH2; Ketoconazole results in decreased activity of KCNH2 protein
Ketoconazole affects the localization of KCNH2; Ketoconazole affects the localization of KCNH2 protein mutant form

PMID:9694927 PMID:15272206 PMID:16542653 PMID:17965736 PMID:24052561 More...

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

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potassium channel tetramerization domain containing 12

decreases expression

Ketoconazole results in decreased expression of KCTD12 mRNA

NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282

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potassium channel tetramerisation domain containing 12b

decreases expression

Ketoconazole results in decreased expression of KCTD12B mRNA

NCBI chr X:17,643,707...17,654,820
Ensembl chr X:17,643,615...17,654,820

G

lysine demethylase 2B

affects expression

Ketoconazole affects the expression of KDM2B mRNA

NCBI chr12:33,566,530...33,701,366
Ensembl chr12:33,574,657...33,701,355

G

lysine demethylase 3A

increases expression

Ketoconazole results in increased expression of KDM3A mRNA

NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073

G

Kelch-like ECH-associated protein 1

increases expression

Ketoconazole results in increased expression of KEAP1 mRNA

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

KLF transcription factor 11

decreases expression

Ketoconazole results in decreased expression of KLF11 mRNA

NCBI chr 6:41,285,699...41,297,548
Ensembl chr 6:41,285,842...41,297,550

G

kallikrein 1

increases expression

Ketoconazole results in increased expression of KLK1 mRNA

NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754

G

kallikrein 1-related peptidase C10

multiple interactions

[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of KLK3 protein

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

kallikrein related-peptidase 6

multiple interactions
increases expression

Ketoconazole promotes the reaction [Calcitriol results in increased expression of KLK6 mRNA]
Ketoconazole results in increased expression of KLK6 mRNA

PMID:26485663 PMID:37077353

NCBI chr 1:94,278,863...94,286,136
Ensembl chr 1:94,280,340...94,286,121

G

karyopherin subunit alpha 3

increases expression

Ketoconazole results in increased expression of KPNA3 mRNA

NCBI chr15:35,536,310...35,610,066
Ensembl chr15:35,536,316...35,610,419

G

laminin subunit beta 3

increases expression

Ketoconazole results in increased expression of LAMB3 mRNA

NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405

G

lysosomal protein transmembrane 4 alpha

increases expression

Ketoconazole results in increased expression of LAPTM4A mRNA

NCBI chr 6:31,719,287...31,737,023
Ensembl chr 6:31,718,976...31,737,020

G

lipocalin 2

decreases expression

Ketoconazole results in decreased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

luteinizing hormone subunit beta

multiple interactions

Ketoconazole inhibits the reaction [LHB protein results in increased abundance of Testosterone]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

luteinizing hormone/choriogonadotropin receptor

decreases expression

Ketoconazole results in decreased expression of LHCGR mRNA

NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521

G

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

increases expression

Ketoconazole results in increased expression of LHPP mRNA

NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578

G

LIM homeobox 1

increases expression

Ketoconazole results in increased expression of LHX1 mRNA

NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617

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lamin B1

decreases expression

Ketoconazole results in decreased expression of LMNB1 mRNA

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

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lunapark, ER junction formation factor

increases expression

Ketoconazole results in increased expression of LNPK mRNA

NCBI chr 3:59,418,872...59,487,029
Ensembl chr 3:59,424,286...59,486,518

G

lysyl oxidase

affects expression

Ketoconazole affects the expression of LOX mRNA

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

G

leucine rich repeat containing 17

decreases expression

Ketoconazole results in decreased expression of LRRC17 mRNA

NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:13,501,436...13,531,845

G

leucine rich repeat containing 28

decreases expression

Ketoconazole results in decreased expression of LRRC28 mRNA

NCBI chr 1:121,116,833...121,245,805
Ensembl chr 1:121,127,733...121,245,784

G

leucine rich repeat containing 41

decreases expression

Ketoconazole results in decreased expression of LRRC41 mRNA

NCBI chr 5:129,554,547...129,575,450
Ensembl chr 5:129,554,547...129,575,449

G

leucine rich repeat containing 75A

increases expression

Ketoconazole results in increased expression of LRRC75A mRNA

NCBI chr10:47,298,222...47,343,301
Ensembl chr10:47,297,288...47,343,664

G

LRR binding FLII interacting protein 2

decreases expression

Ketoconazole results in decreased expression of LRRFIP2 mRNA

NCBI chr 8:111,091,453...111,193,947
Ensembl chr 8:111,091,503...111,193,255

G

LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

increases expression

Ketoconazole results in increased expression of LSM5 mRNA

NCBI chr 4:85,951,073...85,954,289
Ensembl chr 6:104,652,477...104,654,165
Ensembl chr 4:104,652,477...104,654,165

G

lanosterol synthase

increases expression

Ketoconazole results in increased expression of LSS mRNA

PMID:15342952 PMID:17175557 PMID:17567588

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

mannose-6-phosphate receptor, cation dependent

decreases expression

Ketoconazole results in decreased expression of M6PR mRNA

NCBI chr 4:155,501,080...155,510,219
Ensembl chr 4:155,500,921...155,510,216

G

macroH2A.1 histone

affects expression

Ketoconazole affects the expression of MACROH2A1 mRNA

NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072

G

mucosal vascular addressin cell adhesion molecule 1

multiple interactions

Ketoconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]

NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703

G

mitochondrial assembly of ribosomal large subunit 1

increases expression

Ketoconazole results in increased expression of MALSU1 mRNA

NCBI chr 4:78,051,090...78,059,913
Ensembl chr 4:78,051,059...78,059,905

G

mannosidase beta

affects expression

Ketoconazole affects the expression of MANBA mRNA

NCBI chr 2:223,910,432...224,002,988
Ensembl chr 2:223,910,432...224,002,983

G

mitogen-activated protein kinase kinase kinase kinase 5

decreases expression

Ketoconazole results in decreased expression of MAP4K5 mRNA

NCBI chr 6:88,284,087...88,377,118
Ensembl chr 6:88,284,094...88,376,799

G

mitogen activated protein kinase 14

decreases expression

Ketoconazole results in decreased expression of MAPK14 mRNA

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen-activated protein kinase 8

increases phosphorylation
increases expression

Ketoconazole results in increased phosphorylation of MAPK8 protein
Ketoconazole results in increased expression of MAPK8 mRNA

PMID:19631732 PMID:25787151

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

muscleblind-like splicing regulator 1

decreases expression

Ketoconazole results in decreased expression of MBNL1 mRNA

NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368

G

melanocortin 3 receptor

decreases expression

Ketoconazole results in decreased expression of MC3R mRNA

NCBI chr 3:161,016,347...161,017,444
Ensembl chr 3:161,016,347...161,017,444

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions

[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

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minichromosome maintenance complex component 7

increases expression

Ketoconazole results in increased expression of MCM7 mRNA

NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063

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malate dehydrogenase 1

increases expression

Ketoconazole results in increased expression of MDH1 mRNA

NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925

G

malic enzyme 1

increases expression

Ketoconazole results in increased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Ketoconazole results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

mitofusin 1

increases expression

Ketoconazole results in increased expression of MFN1 mRNA

NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640

G

monoglyceride lipase

increases expression

Ketoconazole results in increased expression of MGLL mRNA

NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179

G

matrix Gla protein

affects expression

Ketoconazole affects the expression of MGP mRNA

NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667

G

microsomal glutathione S-transferase 1

increases expression

Ketoconazole results in increased expression of MGST1 mRNA

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

microsomal glutathione S-transferase 2

increases expression

Ketoconazole results in increased expression of MGST2 mRNA

NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828

G

MHC class I polypeptide-related sequence B

increases expression

Ketoconazole results in increased expression of MICB mRNA

NCBI chr 1:78,495,779...78,513,030
Ensembl chr 1:78,495,779...78,512,827

G

mitochondrial calcium uptake 1

increases expression

Ketoconazole results in increased expression of MICU1 mRNA

NCBI chr20:27,668,681...27,816,322
Ensembl chr20:27,668,747...27,814,964

G

MHC I like leukocyte 1

increases expression

Ketoconazole results in increased expression of MICA mRNA

NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930

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marker of proliferation Ki-67

increases expression

Ketoconazole results in increased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

makorin, ring finger protein, 3

decreases expression

Ketoconazole results in decreased expression of MKRN3 mRNA

NCBI chr 1:115,926,774...115,929,288
Ensembl chr 1:115,926,776...115,929,283

G

MAX dimerization protein MLX

affects expression

Ketoconazole affects the expression of MLX mRNA

NCBI chr10:86,019,216...86,024,326
Ensembl chr10:86,019,588...86,032,350

G

malonyl-CoA decarboxylase

increases expression

Ketoconazole results in increased expression of MLYCD mRNA

NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793

G

metabolism of cobalamin associated B

increases expression

Ketoconazole results in increased expression of MMAB mRNA

NCBI chr12:42,159,109...42,172,518
Ensembl chr12:42,159,089...42,172,490

G

matrix metallopeptidase 14

decreases expression

Ketoconazole results in decreased expression of MMP14 mRNA

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

myelin protein zero-like 1

decreases expression

Ketoconazole results in decreased expression of MPZL1 mRNA

NCBI chr13:77,852,467...77,889,305
Ensembl chr13:77,852,467...77,896,616

G

melanocortin 2 receptor accessory protein 2

increases expression

Ketoconazole results in increased expression of MRAP2 mRNA

NCBI chr 8:88,088,293...88,144,636
Ensembl chr 8:88,088,272...88,143,886

G

muscle RAS oncogene homolog

increases expression

Ketoconazole results in increased expression of MRAS mRNA

NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408

G

mitochondrial ribosomal protein L11

decreases expression

Ketoconazole results in decreased expression of MRPL11 mRNA

NCBI chr 1:202,264,419...202,267,288
Ensembl chr 1:202,264,471...202,267,756

G

mitochondrial ribosomal protein L18

increases expression

Ketoconazole results in increased expression of MRPL18 mRNA

NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987

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mitochondrial ribosomal protein L32

increases expression

Ketoconazole results in increased expression of MRPL32 mRNA

NCBI chr17:50,565,133...50,568,000
Ensembl chr17:50,565,055...50,568,010

G

mitochondrial ribosomal protein S18B

affects expression

Ketoconazole affects the expression of MRPS18B mRNA

NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260

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mitochondrial ribosomal protein S30

decreases expression

Ketoconazole results in decreased expression of MRPS30 mRNA

NCBI chr 2:50,456,253...50,463,128
Ensembl chr 2:50,456,255...50,463,105

G

mitochondrial ribosomal protein S31

increases expression

Ketoconazole results in increased expression of MRPS31 mRNA

NCBI chr16:69,601,349...69,621,609
Ensembl chr16:69,601,349...69,630,654

G

MRT4 homolog, ribosome maturation factor

increases expression

Ketoconazole results in increased expression of MRTO4 mRNA

NCBI chr 5:151,601,780...151,608,533
Ensembl chr 5:151,601,780...151,608,287

G

methylsterol monooxygenase 1

affects expression
increases expression
multiple interactions

Ketoconazole affects the expression of MSMO1 mRNA
Ketoconazole results in increased expression of MSMO1 mRNA
EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA]

PMID:16330322 PMID:18355885

NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016

G

moesin

increases expression

Ketoconazole results in increased expression of MSN mRNA

NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628

G

metallothionein 1

increases expression

Ketoconazole results in increased expression of MT1A mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

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mitochondrial carrier 2

increases expression

Ketoconazole results in increased expression of MTCH2 mRNA

NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

decreases expression

Ketoconazole results in decreased expression of MTHFD1L mRNA

NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905

G

myotubularin related protein 2

decreases expression

Ketoconazole results in decreased expression of MTMR2 mRNA

NCBI chr 8:10,617,993...10,670,724
Ensembl chr 8:10,617,993...10,668,172

G

mevalonate diphosphate decarboxylase

increases expression

Ketoconazole results in increased expression of MVD mRNA

NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971

G

MYD88, innate immune signal transduction adaptor

increases expression

Ketoconazole results in increased expression of MYD88 mRNA

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

myosin heavy chain 14

increases expression

Ketoconazole results in increased expression of MYH14 mRNA

NCBI chr 1:95,096,266...95,158,861
Ensembl chr 1:95,096,266...95,158,836

G

myosin heavy chain 7

decreases expression

Ketoconazole results in decreased expression of MYH7 mRNA

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

myelin transcription factor 1

increases expression

Ketoconazole results in increased expression of MYT1 mRNA

NCBI chr 3:168,890,466...168,950,341
Ensembl chr 3:168,886,089...168,950,341

G

nuclear autoantigenic sperm protein

increases expression

Ketoconazole results in increased expression of NASP mRNA

NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928

G

NCBP2 antisense 2 (head to head)

increases expression

Ketoconazole results in increased expression of NCBP2AS2 mRNA

NCBI chr11:68,829,950...68,830,715
Ensembl chr11:68,829,983...68,830,708

G

neutrophil cytosolic factor 1

decreases expression
increases expression

Ketoconazole results in decreased expression of NCF1 mRNA
Ketoconazole results in increased expression of NCF1 mRNA

PMID:25787151 PMID:37077353

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

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nuclear receptor coactivator 1

multiple interactions

Ketoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]

PMID:12072427 PMID:16819505 PMID:17438109 PMID:17998298 PMID:23525103 More...

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

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nuclear receptor co-repressor 2

multiple interactions

Ketoconazole inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein]

PMID:12072427 PMID:29356861

NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319

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natural killer cell cytotoxicity receptor 3 ligand 1

increases expression

Ketoconazole results in increased expression of NCR3LG1 mRNA; Ketoconazole results in increased expression of NCR3LG1 protein

NCBI chr 1:96,565,664...96,581,825
Ensembl chr 1:96,574,455...96,580,466

G

N-myc downstream regulated 1

increases expression

Ketoconazole results in increased expression of NDRG1 mRNA

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

NADH:ubiquinone oxidoreductase subunit A5

increases expression

Ketoconazole results in increased expression of NDUFA5 mRNA

NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598

G

nei-like DNA glycosylase 2

increases expression

Ketoconazole results in increased expression of NEIL2 mRNA

NCBI chr15:37,444,676...37,454,863
Ensembl chr15:37,445,381...37,454,863

G

neuroepithelial cell transforming 1

increases expression

Ketoconazole results in increased expression of NET1 mRNA

NCBI chr17:66,341,251...66,370,445
Ensembl chr17:66,340,728...66,370,441

G

neuropilin and tolloid like 1

decreases expression

Ketoconazole results in decreased expression of NETO1 mRNA

NCBI chr18:79,635,633...79,753,913
Ensembl chr18:79,635,633...79,749,030

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

[Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NFE2L2 protein
Ketoconazole results in increased expression of NFE2L2 mRNA; Ketoconazole results in increased expression of NFE2L2 protein

PMID:21753779 PMID:31168027 PMID:37077353

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor receptor

increases expression

Ketoconazole results in increased expression of NGFR mRNA

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

niban apoptosis regulator 1

decreases expression

Ketoconazole results in decreased expression of NIBAN1 mRNA

NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729

G

niban apoptosis regulator 2

decreases expression

Ketoconazole results in decreased expression of NIBAN2 mRNA

NCBI chr 3:16,174,674...16,224,293
Ensembl chr 3:16,174,659...16,224,293

G

ninjurin 1

increases expression

Ketoconazole results in increased expression of NINJ1 mRNA

NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704

G

NLR family, pyrin domain containing 3

increases expression

Ketoconazole results in increased expression of NLRP3 mRNA

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 3

decreases expression

Ketoconazole results in decreased expression of NOS3 mRNA

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

nucleophosmin/nucleoplasmin 2

increases expression

Ketoconazole results in increased expression of NPM2 mRNA

NCBI chr15:45,722,282...45,729,336
Ensembl chr15:45,722,400...45,729,726

G

natriuretic peptide receptor 3

decreases expression

Ketoconazole results in decreased expression of NPR3 mRNA

NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955

G

neuropeptide W

decreases expression

Ketoconazole results in decreased expression of NPW mRNA

NCBI chr10:13,680,275...13,681,618
Ensembl chr10:13,680,321...13,681,586

G

neuropeptide Y receptor Y2

decreases expression

Ketoconazole results in decreased expression of NPY2R mRNA

NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

Ketoconazole results in increased expression of NQO1 mRNA; Ketoconazole results in increased expression of NQO1 protein
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NQO1 mRNA
AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of NQO1 mRNA]

PMID:17923278 PMID:21753779 PMID:31168027

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 0, group B, member 2

increases expression

Ketoconazole results in increased expression of NR0B2 mRNA

PMID:15342952 PMID:17175557

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group D, member 1

increases expression

Ketoconazole results in increased expression of NR1D1 mRNA

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

G

nuclear receptor subfamily 1, group H, member 2

multiple interactions
increases expression

Ketoconazole inhibits the reaction [T0901317 results in increased activity of NR1H2 protein]
Ketoconazole results in increased expression of NR1H2 mRNA

PMID:16819505 PMID:37077353

NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377

G

nuclear receptor subfamily 1, group H, member 3

multiple interactions

Ketoconazole inhibits the reaction [Clofibrate results in increased expression of NR1H3 mRNA]
Ketoconazole inhibits the reaction [T0901317 results in increased activity of NR1H3 protein]

PMID:14690017 PMID:16819505

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

Ketoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
decreases response to substance
decreases expression
increases activity

[Ketoconazole co-treated with Rifampin] results in increased activity of NR1I2 protein; Ketoconazole binds to and results in decreased activity of NR1I2 protein; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein results in decreased uptake of and results in decreased metabolism of Glucose]; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Ketoconazole inhibits the reaction [Rifampin binds to and results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]
NR1I2 protein mutant form results in decreased susceptibility to Ketoconazole
Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein]
Ketoconazole results in decreased expression of NR1I2 mRNA; Ketoconazole results in decreased expression of NR1I2 protein
Ketoconazole results in increased activity of NR1I2 protein

PMID:12072427 PMID:16608920 PMID:16819505 PMID:17438109 PMID:17998298 More...

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions
decreases activity
decreases expression

[Ketoconazole co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Ketoconazole binds to and results in decreased activity of NR1I3 protein alternative form; Ketoconazole inhibits the reaction [Dexamethasone results in increased expression of NR1I3 mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased activity of NR1I3 protein]
Ketoconazole results in decreased activity of NR1I3 protein
Ketoconazole inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein]
Ketoconazole results in decreased expression of NR1I3 mRNA

PMID:16608920 PMID:16819505 PMID:20869355

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 2, group F, member 1

increases expression

Ketoconazole results in increased expression of NR2F1 mRNA

NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123

G

nuclear receptor subfamily 3, group C, member 1

affects binding
multiple interactions
decreases activity

Ketoconazole binds to NR3C1 protein
Ketoconazole inhibits the reaction [Dexamethasone binds to and results in increased activity of NR3C1 protein]
Ketoconazole results in decreased activity of NR3C1 protein

PMID:15755314 PMID:16608920 PMID:25000292

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 5, group A, member 1

decreases expression

Ketoconazole results in decreased expression of NR5A1 mRNA

NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328

G

neuronal regeneration related protein

affects expression

Ketoconazole affects the expression of NREP mRNA

NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591

G

nuclear receptor interacting protein 3

increases expression

Ketoconazole results in increased expression of NRIP3 mRNA

NCBI chr 1:163,789,738...163,815,036
Ensembl chr 1:163,789,738...163,815,600

G

NAD(P) dependent steroid dehydrogenase-like

increases expression

Ketoconazole results in increased expression of NSDHL mRNA

NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142

G

NMDA receptor synaptonuclear signaling and neuronal migration factor

increases expression

Ketoconazole results in increased expression of NSMF mRNA

NCBI chr 3:7,861,846...7,870,615
Ensembl chr 3:7,861,872...7,870,614

G

netrin G1

decreases expression

Ketoconazole results in decreased expression of NTNG1 mRNA

NCBI chr 2:197,462,785...197,827,681
Ensembl chr 2:197,463,945...197,826,997

G

negative regulator of ubiquitin-like proteins 1

increases expression

Ketoconazole results in increased expression of NUB1 mRNA

NCBI chr 4:10,442,917...10,473,689
Ensembl chr 4:10,442,917...10,473,694

G

nudix hydrolase 4

increases expression

Ketoconazole results in increased expression of NUDT4 mRNA

NCBI chr 7:30,188,100...30,204,615
Ensembl chr 7:30,188,100...30,204,615

G

nucleoporin 214

decreases expression

Ketoconazole results in decreased expression of NUP214 mRNA

NCBI chr 3:15,255,111...15,340,568
Ensembl chr 3:15,255,119...15,340,568

G

nucleoporin 62

decreases expression

Ketoconazole results in decreased expression of NUP62 mRNA

NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174

G

nuclear protein 1, transcriptional regulator

increases expression

Ketoconazole results in increased expression of NUPR1 mRNA

PMID:15342952 PMID:17175557 PMID:17567588

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

out at first homolog

affects expression

Ketoconazole affects the expression of OAF mRNA

NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334

G

OCIA domain containing 1

increases expression

Ketoconazole results in increased expression of OCIAD1 mRNA

NCBI chr14:34,897,851...34,915,291
Ensembl chr14:34,897,847...34,915,286

G

ornithine decarboxylase 1

increases expression

Ketoconazole results in increased expression of ODC1 mRNA

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

oxysterol binding protein-like 8

increases expression

Ketoconazole results in increased expression of OSBPL8 mRNA

NCBI chr 7:46,596,944...46,749,888
Ensembl chr 7:46,596,983...46,749,888

G

ovo like transcriptional repressor 1

increases expression

Ketoconazole results in increased expression of OVOL1 mRNA; Ketoconazole results in increased expression of OVOL1 protein

NCBI chr 1:202,855,261...202,868,858
Ensembl chr 1:202,855,265...202,866,831

G

oxytocin/neurophysin I prepropeptide

increases expression

Ketoconazole results in increased expression of OXT mRNA

NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490

G

phosphofurin acidic cluster sorting protein 1

decreases expression

Ketoconazole results in decreased expression of PACS1 mRNA

NCBI chr 1:202,437,503...202,569,473
Ensembl chr 1:202,437,505...202,569,473

G

palladin, cytoskeletal associated protein

decreases expression

Ketoconazole results in decreased expression of PALLD mRNA

NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337

G

poly(A) polymerase gamma

increases expression

Ketoconazole results in increased expression of PAPOLG mRNA

NCBI chr14:97,827,712...97,861,024
Ensembl chr14:97,827,712...97,861,024

G

poly (ADP-ribose) glycohydrolase

increases expression

Ketoconazole results in increased expression of PARG mRNA

NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273

G

poly (ADP-ribose) polymerase 1

increases expression

Ketoconazole results in increased expression of PARP1 mRNA

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pyruvate carboxylase

affects expression
increases expression

Ketoconazole affects the expression of PC mRNA
Ketoconazole results in increased expression of PC mRNA

PMID:18355885 PMID:37077353

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380

G

pterin-4 alpha-carbinolamine dehydratase 1

increases expression

Ketoconazole results in increased expression of PCBD1 mRNA

NCBI chr20:29,037,545...29,044,322
Ensembl chr20:28,953,864...29,044,292
Ensembl chr20:28,953,864...29,044,292

G

protocadherin 9

increases expression

Ketoconazole results in increased expression of PCDH9 mRNA

NCBI chr15:69,340,108...70,237,531
Ensembl chr15:69,340,645...70,237,538

G

proliferating cell nuclear antigen

increases expression

Ketoconazole results in increased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

PEST proteolytic signal containing nuclear protein

decreases expression

Ketoconazole results in decreased expression of PCNP mRNA

NCBI chr11:44,592,766...44,607,372
Ensembl chr11:44,592,742...44,607,348

G

proprotein convertase subtilisin/kexin type 5

increases expression

Ketoconazole results in increased expression of PCSK5 mRNA

NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600

G

proprotein convertase subtilisin/kexin type 9

increases expression

Ketoconazole results in increased expression of PCSK9 mRNA

NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688

G

phosphatidylcholine transfer protein

increases expression

Ketoconazole results in increased expression of PCTP mRNA

NCBI chr10:74,808,887...74,856,260
Ensembl chr10:74,808,887...74,849,867

G

phosphodiesterase 3B

decreases expression

Ketoconazole results in decreased expression of PDE3B mRNA

NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334

G

pyruvate dehydrogenase E1 subunit beta

increases expression

Ketoconazole results in increased expression of PDHB mRNA

NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500

G

PDZ and LIM domain 5

increases expression

Ketoconazole results in increased expression of PDLIM5 mRNA

NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275

G

prodynorphin

decreases expression

Ketoconazole results in decreased expression of PDYN mRNA

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

G

proliferation and apoptosis adaptor protein 15

increases expression

Ketoconazole results in increased expression of PEA15 mRNA

NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499

G

peroxisomal trans-2-enoyl-CoA reductase

affects expression

Ketoconazole affects the expression of PECR mRNA

NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511

G

peptidase D

increases expression

Ketoconazole results in increased expression of PEPD mRNA

NCBI chr 1:87,536,650...87,681,233
Ensembl chr 1:87,536,609...87,681,231

G

period circadian regulator 3

decreases expression

Ketoconazole results in decreased expression of PER3 mRNA

NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607

G

p53 apoptosis effector related to PMP22

decreases expression

Ketoconazole results in decreased expression of PERP mRNA

NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511

G

platelet factor 4

increases expression

Ketoconazole results in increased expression of PF4 mRNA

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

placental growth factor

increases expression

Ketoconazole results in increased expression of PGF mRNA

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

progesterone receptor

increases expression

Ketoconazole results in increased expression of PGR mRNA

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

PHD finger protein 6

increases expression

Ketoconazole results in increased expression of PHF6 mRNA

NCBI chr X:132,656,658...132,699,720
Ensembl chr X:132,656,672...132,699,127

G

PHD finger protein 7

increases expression

Ketoconazole results in increased expression of PHF7 mRNA

NCBI chr16:6,433,535...6,446,314
Ensembl chr16:6,433,537...6,446,911

G

Pim-1 proto-oncogene, serine/threonine kinase

decreases expression

Ketoconazole results in decreased expression of PIM1 mRNA

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

G

phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha

increases expression

Ketoconazole results in increased expression of PIP5K1A mRNA

NCBI chr 2:182,628,299...182,671,584
Ensembl chr 2:182,628,300...182,671,598

G

plakophilin 2

increases expression

Ketoconazole results in increased expression of PKP2 mRNA

NCBI chr11:84,661,783...84,727,730
Ensembl chr11:84,661,783...84,727,730

G

phospholipase A2, group III

increases expression

Ketoconazole results in increased expression of PLA2G3 mRNA

NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913

G

phospholipase A2 group VII

decreases expression

Ketoconazole results in decreased expression of PLA2G7 mRNA

NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476

G

phospholipase A and acyltransferase 3

increases expression

Ketoconazole results in increased expression of PLAAT3 mRNA

NCBI chr 1:204,782,608...204,816,397
Ensembl chr 1:204,782,729...204,817,667

G

PLAG1 zinc finger

decreases expression

Ketoconazole results in decreased expression of PLAG1 mRNA

NCBI chr 5:16,902,057...16,956,727
Ensembl chr 5:16,905,394...16,913,647

G

phosphatidylinositol-specific phospholipase C, X domain containing 2

increases expression

Ketoconazole results in increased expression of PLCXD2 mRNA

NCBI chr11:54,800,977...54,853,348
Ensembl chr11:54,789,477...54,853,344

G

pleckstrin homology domain containing A4

increases expression

Ketoconazole results in increased expression of PLEKHA4 mRNA

NCBI chr 1:96,005,824...96,028,826
Ensembl chr 1:96,006,000...96,028,826

G

perilipin 4

increases expression

Ketoconazole results in increased expression of PLIN4 mRNA

NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056

G

phospholipid scramblase 4

decreases expression

Ketoconazole results in decreased expression of PLSCR4 mRNA

NCBI chr 8:92,987,290...93,026,056
Ensembl chr 8:92,987,381...93,026,049

G

phosphomannomutase 1

increases expression

Ketoconazole results in increased expression of PMM1 mRNA

NCBI chr 7:113,466,632...113,477,004
Ensembl chr 7:113,466,632...113,477,022

G

phosphomevalonate kinase

increases expression

Ketoconazole results in increased expression of PMVK mRNA

PMID:28263823 PMID:37077353

NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364

G

patatin-like phospholipase domain containing 6

decreases expression

Ketoconazole results in decreased expression of PNPLA6 mRNA

NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734

G

RNA polymerase I and III subunit D

decreases expression

Ketoconazole results in decreased expression of POLR1D mRNA

NCBI chr12:7,970,592...8,004,157
Ensembl chr12:7,970,595...8,005,624

G

proopiomelanocortin

decreases expression

Ketoconazole results in decreased expression of POMC protein modified form

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

paraoxonase 2

increases expression

Ketoconazole results in increased expression of PON2 mRNA

NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248

G

cytochrome p450 oxidoreductase

affects expression
decreases expression
increases expression
multiple interactions

Ketoconazole affects the expression of POR mRNA
Ketoconazole results in decreased expression of POR mRNA
Ketoconazole results in increased expression of POR protein
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]

PMID:17966066 PMID:18355885 PMID:24120545 PMID:36653537

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

POU class 2 homeobox 1

decreases expression

Ketoconazole results in decreased expression of POU2F1 mRNA

NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363

G

POU class 5 homeobox 1

decreases expression

Ketoconazole results in decreased expression of POU5F1 mRNA

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator activated receptor alpha

multiple interactions

Ketoconazole inhibits the reaction [Clofibrate results in increased expression of PPARA mRNA]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

increases expression

Ketoconazole results in increased expression of PPARD mRNA

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

PPARG coactivator 1 alpha

decreases expression

Ketoconazole results in decreased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

PPARG coactivator 1 beta

decreases expression

Ketoconazole results in decreased expression of PPARGC1B mRNA

NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194

G

protein phosphatase 2 catalytic subunit beta

decreases expression

Ketoconazole results in decreased expression of PPP2CB mRNA

NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576

G

protein phosphatase 2, regulatory subunit B, beta

increases expression

Ketoconazole results in increased expression of PPP2R2B mRNA

NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025

G

protein phosphatase 2, regulatory subunit B'', alpha

decreases expression

Ketoconazole results in decreased expression of PPP2R3A mRNA

NCBI chr 8:101,703,512...101,841,530
Ensembl chr 8:101,704,778...101,841,502

G

polyglutamine binding protein 1

decreases expression

Ketoconazole results in decreased expression of PQBP1 mRNA

NCBI chr X:14,603,516...14,608,091
Ensembl chr X:14,603,539...14,608,087

G

protein regulator of cytokinesis 1

decreases expression

Ketoconazole results in decreased expression of PRC1 mRNA

NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765

G

proline rich mitotic checkpoint control factor

increases expression

Ketoconazole results in increased expression of PRCC mRNA

NCBI chr 2:173,326,261...173,351,799
Ensembl chr 2:173,326,259...173,351,825

G

PR/SET domain 1

decreases expression

Ketoconazole results in decreased expression of PRDM1 mRNA

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

G

peroxiredoxin 3

decreases expression

Ketoconazole results in decreased expression of PRDX3 mRNA

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

G

protein kinase cAMP-dependent type I regulatory subunit beta

decreases expression

Ketoconazole results in decreased expression of PRKAR1B mRNA

NCBI chr12:15,492,233...15,624,942
Ensembl chr12:15,511,801...15,624,942

G

protein kinase cGMP-dependent 2

increases expression

Ketoconazole results in increased expression of PRKG2 mRNA

NCBI chr14:10,559,882...10,668,479
Ensembl chr14:10,559,882...10,666,888

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions
increases response to substance
increases expression

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN protein]; tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN protein]
PRKN protein results in increased susceptibility to Ketoconazole
Ketoconazole results in increased expression of PRKN mRNA; Ketoconazole results in increased expression of PRKN protein

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

prolactin

decreases expression

Ketoconazole results in decreased expression of PRL mRNA

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

proteasome 20S subunit beta 8

decreases expression

Ketoconazole results in decreased expression of PSMB8 mRNA

NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283

G

proteasome 26S subunit, ATPase 2

decreases expression

Ketoconazole results in decreased expression of PSMC2 mRNA

NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185

G

proteasome 26S subunit, non-ATPase 13

decreases expression

Ketoconazole results in decreased expression of PSMD13 mRNA

NCBI chr 1:195,964,617...195,976,895
Ensembl chr 1:195,964,138...195,976,905

G

proteasome 26S subunit, non-ATPase 5

increases expression

Ketoconazole results in increased expression of PSMD5 mRNA

NCBI chr 3:18,133,715...18,151,000
Ensembl chr 3:18,133,717...18,151,029

G

proteasome assembly chaperone 3

increases expression

Ketoconazole results in increased expression of PSMG3 mRNA

NCBI chr12:14,809,440...14,812,357
Ensembl chr12:14,809,450...14,812,342

G

proteasome assembly chaperone 4

increases expression

Ketoconazole results in increased expression of PSMG4 mRNA

NCBI chr17:30,710,682...30,718,035
Ensembl chr17:30,710,682...30,718,082

G

phosphatase and tensin homolog

decreases expression

Ketoconazole results in decreased expression of PTEN mRNA

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin D2 synthase

decreases expression
increases expression

Ketoconazole results in decreased expression of PTGDS mRNA
Ketoconazole results in increased expression of PTGDS mRNA

PMID:31099283 PMID:36653537

NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833

G

prostaglandin E receptor 2

multiple interactions
increases response to substance

PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
PTGER2 protein results in increased susceptibility to Ketoconazole

NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714

G

prostaglandin E receptor 3

multiple interactions
increases expression
increases response to substance

PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
Ketoconazole results in increased expression of PTGER3 mRNA
PTGER3 protein results in increased susceptibility to Ketoconazole

PMID:16784723 PMID:37077353

NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein]
Ketoconazole results in increased expression of PTGS2 mRNA

PMID:12164941 PMID:32816093

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone

multiple interactions

Ketoconazole inhibits the reaction [25-hydroxyvitamin D results in decreased expression of PTH mRNA]

NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530

G

protein tyrosine phosphatase, non-receptor type 14

increases expression

Ketoconazole results in increased expression of PTPN14 mRNA

NCBI chr13:101,268,258...101,420,508
Ensembl chr13:101,268,416...101,414,088

G

protein tyrosine phosphatase, receptor type, F

decreases expression

Ketoconazole results in decreased expression of PTPRF mRNA

NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023

G

pentraxin 3

affects expression

Ketoconazole affects the expression of PTX3 mRNA

NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323

G

glycogen phosphorylase L

increases expression

Ketoconazole results in increased expression of PYGL mRNA

NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310

G

quiescin sulfhydryl oxidase 1

decreases expression

Ketoconazole results in decreased expression of QSOX1 mRNA

NCBI chr13:67,949,780...67,987,434
Ensembl chr13:67,949,780...67,987,459

G

RAB3B, member RAS oncogene family

increases expression

Ketoconazole results in increased expression of RAB3B mRNA

NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401

G

RAB9A, member RAS oncogene family

increases expression

Ketoconazole results in increased expression of RAB9A mRNA

NCBI chr X:27,955,552...28,009,870
Ensembl chr X:27,952,204...28,001,622

G

ral guanine nucleotide dissociation stimulator like 1

decreases expression

Ketoconazole results in decreased expression of RGL1 mRNA

NCBI chr13:64,634,489...64,904,170
Ensembl chr13:64,635,246...64,904,191

G

Rap guanine nucleotide exchange factor 1

decreases expression

Ketoconazole results in decreased expression of RAPGEF1 mRNA

NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984

G

Rap guanine nucleotide exchange factor 4

decreases expression

Ketoconazole results in decreased expression of RAPGEF4 mRNA

NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316

G

retinoic acid receptor, beta

increases expression
decreases expression

Ketoconazole results in increased expression of RARB mRNA
Ketoconazole results in decreased expression of RARB mRNA

PMID:28263823 PMID:37077353

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

retinoic acid receptor responder 2

increases expression

Ketoconazole results in increased expression of RARRES2 mRNA

NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556

G

RB transcriptional corepressor like 2

affects expression

Ketoconazole affects the expression of RBL2 mRNA

NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572

G

RNA binding motif protein 26

decreases expression

Ketoconazole results in decreased expression of RBM26 mRNA

NCBI chr15:81,884,783...81,964,245
Ensembl chr15:81,887,219...81,964,118

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

renin

decreases expression

Ketoconazole results in decreased expression of REN protein

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

RFT1 homolog

decreases expression

Ketoconazole results in decreased expression of RFT1 mRNA

NCBI chr16:5,827,063...5,861,120
Ensembl chr16:5,827,088...5,861,120

G

regulator of G-protein signaling 16

decreases expression

Ketoconazole results in decreased expression of RGS16 mRNA

NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857

G

RAD9-HUS1-RAD1 interacting nuclear orphan 1

increases expression

Ketoconazole results in increased expression of RHNO1 mRNA

NCBI chr 4:161,634,047...161,639,437
Ensembl chr 4:161,634,048...161,639,371

G

ras homolog family member B

increases expression

Ketoconazole results in increased expression of RHOB mRNA

NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108

G

Rab interacting lysosomal protein-like 1

decreases expression

Ketoconazole results in decreased expression of RILPL1 mRNA

NCBI chr12:32,071,870...32,109,687
Ensembl chr12:32,071,693...32,109,938

G

ribonuclease A family member 4

decreases expression

Ketoconazole results in decreased expression of RNASE4 mRNA

NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117

G

ring finger protein 115

increases expression

Ketoconazole results in increased expression of RNF115 mRNA

NCBI chr 2:184,262,087...184,329,839
Ensembl chr 2:184,262,371...184,329,823

G

ring finger protein 41

increases expression

Ketoconazole results in increased expression of RNF41 mRNA

NCBI chr 7:838,160...876,869
Ensembl chr 7:838,203...865,511

G

ring finger protein 8

decreases expression

Ketoconazole results in decreased expression of RNF8 mRNA

NCBI chr20:7,682,258...7,710,448
Ensembl chr20:7,682,322...7,708,491

G

ribonuclease P and MRP subunit p25

increases expression

Ketoconazole results in increased expression of RPP25 mRNA

NCBI chr 8:57,907,352...57,908,732
Ensembl chr 8:57,907,352...57,908,732

G

ribosomal protein s25

increases expression

Ketoconazole results in increased expression of RPS25 mRNA

NCBI chr 8:44,733,623...44,735,999
Ensembl chr 8:44,733,029...44,737,271

G

ribosomal protein SA

increases expression

Ketoconazole results in increased expression of RPSA mRNA

NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247

G

ribonucleotide reductase regulatory subunit M2

increases expression

Ketoconazole results in increased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

remodeling and spacing factor 1

increases expression

Ketoconazole results in increased expression of RSF1 mRNA

NCBI chr 1:151,892,055...152,015,089
Ensembl chr 1:151,892,434...152,009,051

G

RT1 class II, locus Bb

decreases expression

Ketoconazole results in decreased expression of RT1-BB mRNA

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

RT1 class Ib, locus S3

affects expression

Ketoconazole affects the expression of RT1-S3 mRNA

NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411

G

RUNX family transcription factor 2

multiple interactions
decreases expression

Ketoconazole inhibits the reaction [Calcifediol results in increased expression of RUNX2 mRNA]
Ketoconazole results in decreased expression of RUNX2 mRNA

PMID:21542014 PMID:37077353

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

retinoid X receptor alpha

decreases expression

Ketoconazole results in decreased expression of RXRA mRNA

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

retinoid X receptor gamma

decreases expression

Ketoconazole results in decreased expression of RXRG mRNA

NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167

G

sterile alpha motif domain containing 8

increases expression

Ketoconazole results in increased expression of SAMD8 mRNA

NCBI chr15:2,512,104...2,562,368
Ensembl chr15:2,512,105...2,515,379
Ensembl chr15:2,512,105...2,515,379

G

strawberry notch homolog 1

increases expression

Ketoconazole results in increased expression of SBNO1 mRNA

NCBI chr12:32,175,176...32,234,200
Ensembl chr12:32,185,485...32,230,158

G

sterol-C5-desaturase

increases expression

Ketoconazole results in increased expression of SC5D mRNA

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

scavenger receptor class B, member 1

decreases expression
increases expression

Ketoconazole results in decreased expression of SCARB1 mRNA
Ketoconazole results in increased expression of SCARB1 mRNA

PMID:36621641 PMID:37077353

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

scavenger receptor class B, member 2

decreases expression

Ketoconazole results in decreased expression of SCARB2 mRNA

NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813

G

stearoyl-CoA desaturase

increases expression

Ketoconazole results in increased expression of SCD mRNA; Ketoconazole results in increased expression of SCD1 mRNA
Ketoconazole results in increased expression of SCD mRNA; Ketoconazole results in increased expression of SCD protein

PMID:28263823 PMID:36621641 PMID:37077353

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

secretoglobin, family 1C, member 1

increases expression

Ketoconazole results in increased expression of SCGB1C1 mRNA

NCBI chr 1:195,922,660...195,925,022
Ensembl chr 1:195,923,803...195,925,022

G

sterol carrier protein 2

increases expression

Ketoconazole results in increased expression of SCP2 mRNA

NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287

G

syndecan 1

increases expression

Ketoconazole results in increased expression of SDC1 mRNA

PMID:36621641 PMID:37077353

NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264

G

syndecan 4

increases expression

Ketoconazole results in increased expression of SDC4 mRNA

NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580

G

SECIS binding protein 2

decreases expression

Ketoconazole results in decreased expression of SECISBP2 mRNA

NCBI chr17:13,538,513...13,569,573
Ensembl chr17:13,538,513...13,569,523

G

semaphorin 3A

decreases expression

Ketoconazole results in decreased expression of SEMA3A mRNA

NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432

G

semaphorin 3B

multiple interactions

Ketoconazole promotes the reaction [Calcitriol results in increased expression of SEMA3B mRNA]

NCBI chr 8:108,271,663...108,280,326
Ensembl chr 8:108,271,666...108,282,919

G

semaphorin 3D

affects expression

Ketoconazole affects the expression of SEMA3D mRNA

NCBI chr 4:22,316,769...22,505,930
Ensembl chr 4:22,316,779...22,505,930

G

semaphorin 3E

increases expression

Ketoconazole results in increased expression of SEMA3E mRNA

NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229

G

semaphorin 7A (John Milton Hagen blood group)

increases expression

Ketoconazole results in increased expression of SEMA7A mRNA

NCBI chr 8:58,348,448...58,370,536
Ensembl chr 8:58,348,448...58,370,536

G

serpin family A member 1

increases expression

Ketoconazole results in increased expression of SERPINA1 mRNA

PMID:36653537 PMID:37077353

NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339

G

serpin family A member 3N

increases expression

Ketoconazole results in increased expression of SERPINA3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family B member 1A

multiple interactions

Ketoconazole promotes the reaction [Calcitriol results in increased expression of SERPINB1 mRNA]

NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102

G

serpin family B member 3

multiple interactions

Ketoconazole promotes the reaction [Calcitriol results in decreased expression of SERPINB3 mRNA]

NCBI chr13:23,274,120...23,280,660
Ensembl chr13:23,274,484...23,313,682

G

serpin family H member 1

multiple interactions

Ketoconazole inhibits the reaction [Tunicamycin results in decreased glycosylation of SERPINH1 protein]

NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801

G

SEC14 and spectrin domain containing 1

increases expression

Ketoconazole results in increased expression of SESTD1 mRNA

NCBI chr 3:62,123,590...62,220,759
Ensembl chr 3:62,129,887...62,220,546

G

serum/glucocorticoid regulated kinase 1

increases expression

Ketoconazole results in increased expression of SGK1 mRNA

PMID:36653537 PMID:37077353

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

SH3 domain containing 19

increases expression

Ketoconazole results in increased expression of SH3D19 mRNA

NCBI chr 2:171,356,244...171,516,042
Ensembl chr 2:171,356,251...171,515,561

G

SH3 domain containing GRB2 like 3, endophilin A3

affects expression

Ketoconazole affects the expression of SH3GL3 mRNA

NCBI chr 1:136,124,500...136,255,669
Ensembl chr 1:136,124,499...136,255,584

G

SH3 domain containing ring finger 1

decreases expression

Ketoconazole results in decreased expression of SH3RF1 mRNA

NCBI chr16:28,735,522...28,901,261
Ensembl chr16:28,735,440...28,901,644

G

SHQ1, H/ACA ribonucleoprotein assembly factor

increases expression

Ketoconazole results in increased expression of SHQ1 mRNA

NCBI chr 4:133,213,357...133,305,586
Ensembl chr 4:133,213,361...133,305,586

G

shroom family member 2

increases expression

Ketoconazole results in increased expression of SHROOM2 mRNA

NCBI chr X:21,812,469...21,983,724
Ensembl chr X:21,812,469...21,984,153

G

sirtuin 1

decreases expression

Ketoconazole results in decreased expression of SIRT1 mRNA

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

sirtuin 2

decreases expression

Ketoconazole results in decreased expression of SIRT2 mRNA

NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975

G

src kinase associated phosphoprotein 2

increases expression

Ketoconazole results in increased expression of SKAP2 mRNA

NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891

G

solute carrier family 10 member 1

multiple interactions

[Chenodeoxycholic Acid co-treated with Ketoconazole] results in decreased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 17 member 7

increases expression

Ketoconazole results in increased expression of SLC17A7 mRNA

NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588

G

solute carrier family 18 member A2

multiple interactions

Ketoconazole inhibits the reaction [Maneb results in decreased expression of SLC18A2 protein]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of SLC18A2 protein]

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

G

solute carrier family 25 member 1

increases expression

Ketoconazole results in increased expression of SLC25A1 mRNA

NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781

G

solute carrier family 25 member 20

increases expression

Ketoconazole results in increased expression of SLC25A20 mRNA

NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512

G

solute carrier family 25 member 36

increases expression

Ketoconazole results in increased expression of SLC25A36 mRNA

NCBI chr 8:97,659,848...97,693,735
Ensembl chr 8:97,662,127...97,693,703

G

solute carrier family 25, member 53

decreases expression

Ketoconazole results in decreased expression of SLC25A53 mRNA

NCBI chr X:100,306,917...100,319,662
Ensembl chr X:100,306,915...100,319,863

G

solute carrier family 2 member 1

increases expression

Ketoconazole results in increased expression of SLC2A1 mRNA

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 2 member 3

decreases expression

Ketoconazole results in decreased expression of SLC2A3 mRNA

PMID:15342952 PMID:17567588

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

solute carrier family 38, member 3

decreases expression

Ketoconazole results in decreased expression of SLC38A3 mRNA

NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988

G

solute carrier family 47 member 1

multiple interactions

Ketoconazole inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Ketoconazole inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

solute carrier family 6 member 6

affects expression

Ketoconazole affects the expression of SLC6A6 mRNA

NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875

G

solute carrier family 7 member 11

increases expression

Ketoconazole results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

solute carrier organic anion transporter family, member 1a4

affects expression

Ketoconazole affects the expression of SLCO1A4 mRNA

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

slit guidance ligand 2

increases expression

Ketoconazole results in increased expression of SLIT2 mRNA

NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948

G

secretory leukocyte peptidase inhibitor

decreases expression
increases expression

Ketoconazole results in decreased expression of SLPI mRNA
Ketoconazole results in increased expression of SLPI mRNA

PMID:32816093 PMID:36653537

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1

decreases expression

Ketoconazole results in decreased expression of SMARCC1 mRNA

NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720

G

small integral membrane protein 15

increases expression

Ketoconazole results in increased expression of SMIM15 mRNA

NCBI chr 2:39,528,256...39,533,416
Ensembl chr 2:39,527,425...39,534,237

G

small integral membrane protein 19

decreases expression

Ketoconazole results in decreased expression of SMIM19 mRNA

NCBI chr16:69,551,507...69,564,323
Ensembl chr16:69,553,916...69,567,245

G

single-strand-selective monofunctional uracil-DNA glycosylase 1

decreases expression

Ketoconazole results in decreased expression of SMUG1 mRNA

NCBI chr 7:134,288,565...134,302,179
Ensembl chr 7:134,287,675...134,297,226

G

synuclein, gamma

increases expression

Ketoconazole results in increased expression of SNCG mRNA

NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368

G

sorting nexin 1

increases expression

Ketoconazole results in increased expression of SNX1 mRNA

NCBI chr 8:66,630,086...66,670,418
Ensembl chr 8:66,630,086...66,670,360

G

sorting nexin 18

increases expression

Ketoconazole results in increased expression of SNX18 mRNA

NCBI chr 2:45,232,325...45,258,345
Ensembl chr 2:45,232,325...45,258,345

G

superoxide dismutase 1

increases expression

Ketoconazole results in increased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

SRY-box transcription factor 9

increases expression

Ketoconazole results in increased expression of SOX9 mRNA

NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994

G

Sp1 transcription factor

decreases expression

Ketoconazole results in decreased expression of SP1 mRNA

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

sphingosine kinase 1

increases expression

Ketoconazole results in increased expression of SPHK1 mRNA

NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240

G

spondin 2

decreases expression

Ketoconazole results in decreased expression of SPON2 mRNA

NCBI chr14:77,505,695...77,518,001
Ensembl chr14:77,511,901...77,517,996

G

secreted phosphoprotein 1

increases expression

Ketoconazole results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

spectrin, alpha, non-erythrocytic 1

increases expression

Ketoconazole results in increased expression of SPTAN1 mRNA

NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046

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serine palmitoyltransferase, small subunit A

decreases expression

Ketoconazole results in decreased expression of SPTSSA mRNA

NCBI chr 6:72,144,714...72,156,130
Ensembl chr 6:72,144,714...72,156,214

G

squalene epoxidase

increases expression

Ketoconazole results in increased expression of SQLE mRNA

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618

G

sterol regulatory element binding transcription factor 2

increases expression

Ketoconazole results in increased expression of SREBF2 mRNA

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

signal recognition particle 54A

increases expression

Ketoconazole results in increased expression of SRP54 mRNA

NCBI chr 6:72,587,584...72,626,878
Ensembl chr 6:72,587,605...72,625,189

G

sulfiredoxin 1

decreases expression

Ketoconazole results in decreased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

ST13, Hsp70 interacting protein

affects expression

Ketoconazole affects the expression of ST13 mRNA

NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945

G

steroidogenic acute regulatory protein

increases expression

Ketoconazole results in increased expression of STAR mRNA

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

StAR-related lipid transfer domain containing 4

increases expression

Ketoconazole results in increased expression of STARD4 mRNA

NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024

G

StAR-related lipid transfer domain containing 5

decreases expression

Ketoconazole results in decreased expression of STARD5 mRNA

NCBI chr 1:137,606,151...137,616,017
Ensembl chr 1:137,606,177...137,616,469

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signal transducer and activator of transcription 1

increases expression
multiple interactions

Ketoconazole results in increased expression of STAT1 mRNA
Ketoconazole inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]

PMID:24471457 PMID:25787151

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

decreases expression

Ketoconazole results in decreased expression of STAT3 mRNA

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 5B

decreases expression

Ketoconazole results in decreased expression of STAT5B mRNA

NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668

G

starch binding domain 1

affects expression

Ketoconazole affects the expression of STBD1 mRNA

NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443

G

stanniocalcin 1

affects expression

Ketoconazole affects the expression of STC1 mRNA

NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264

G

stanniocalcin 2

decreases expression

Ketoconazole results in decreased expression of STC2 mRNA

NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973

G

STEAP3 metalloreductase

decreases expression

Ketoconazole results in decreased expression of STEAP3 mRNA

NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519

G

stromal interaction molecule 1

decreases expression

Ketoconazole results in decreased expression of STIM1 mRNA

NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363

G

stathmin 1

affects expression

Ketoconazole affects the expression of STMN1 mRNA

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

G

stathmin 2

decreases expression

Ketoconazole results in decreased expression of STMN2 mRNA

NCBI chr 2:93,204,690...93,252,011
Ensembl chr 2:93,204,692...93,252,011

G

stimulated by retinoic acid 8

increases expression

Ketoconazole results in increased expression of STRA8 mRNA

NCBI chr 4:63,601,443...63,624,777
Ensembl chr 4:63,601,604...63,624,771

G

syntaxin 2

decreases expression

Ketoconazole results in decreased expression of STX2 mRNA

NCBI chr12:27,678,744...27,714,751
Ensembl chr12:27,689,819...27,714,751

G

syntaxin binding protein 5

decreases expression

Ketoconazole results in decreased expression of STXBP5 mRNA

NCBI chr 1:4,182,489...4,335,290
Ensembl chr 1:4,185,529...4,335,101

G

sulfotransferase family 1E member 1

increases expression

Ketoconazole results in increased expression of SULT1E1 mRNA

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

G

SWI5 homologous recombination repair protein

increases expression

Ketoconazole results in increased expression of SWI5 mRNA

NCBI chr 3:15,574,687...15,583,760
Ensembl chr 3:15,564,715...15,583,805

G

synaptonemal complex protein 3

increases expression

Ketoconazole results in increased expression of SYCP3 mRNA

PMID:16574651 PMID:31099283

NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511

G

synaptotagmin 3

decreases expression

Ketoconazole results in decreased expression of SYT3 mRNA

NCBI chr 1:94,880,835...94,895,518
Ensembl chr 1:94,881,247...94,895,246

G

TATA-box binding protein associated factor 5 like 1

affects expression

Ketoconazole affects the expression of TAF5L mRNA

NCBI chr19:51,991,704...52,011,001
Ensembl chr19:51,991,708...52,011,295

G

TATA-box binding protein associated factor 8

increases expression

Ketoconazole results in increased expression of TAF8 mRNA

NCBI chr 9:13,491,892...13,511,713
Ensembl chr 9:13,491,937...13,511,717

G

transgelin

decreases expression
increases expression

Ketoconazole results in decreased expression of TAGLN mRNA
Ketoconazole results in increased expression of TAGLN mRNA

PMID:17175557 PMID:37077353

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

tyrosine aminotransferase

decreases expression

Ketoconazole results in decreased expression of TAT mRNA

PMID:16608920 PMID:25000292

NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031

G

TBC1 domain family member 9

increases expression

Ketoconazole results in increased expression of TBC1D9 mRNA

NCBI chr19:24,842,166...24,951,383
Ensembl chr19:24,842,205...24,943,129

G

tubulin folding cofactor C

increases expression
decreases expression

Ketoconazole results in increased expression of TBCC mRNA
Ketoconazole results in decreased expression of TBCC mRNA

PMID:36621641 PMID:37077353

NCBI chr 9:14,098,855...14,100,043
Ensembl chr 9:14,098,868...14,100,042

G

transforming growth factor beta regulator 1

increases expression

Ketoconazole results in increased expression of TBRG1 mRNA

NCBI chr 8:37,355,274...37,362,933
Ensembl chr 8:37,354,658...37,362,930

G

thromboxane A synthase 1

increases expression

Ketoconazole results in increased expression of TBXAS1 mRNA

NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096

G

transcription factor 4

decreases expression

Ketoconazole results in decreased expression of TCF4 mRNA

NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425

G

tubulin epsilon and delta complex 2

increases expression

Ketoconazole results in increased expression of TEDC2 mRNA

NCBI chr10:13,246,032...13,251,196
Ensembl chr10:13,246,037...13,251,124

G

terminal nucleotidyltransferase 4B

increases expression

Ketoconazole results in increased expression of TENT4B mRNA

NCBI chr19:18,807,616...18,868,969
Ensembl chr19:18,807,525...18,869,537

G

testis expressed 261

affects expression

Ketoconazole affects the expression of TEX261 mRNA

NCBI chr 4:116,253,547...116,260,730
Ensembl chr 4:116,244,600...116,260,253

G

transcription factor Dp-2

decreases expression

Ketoconazole results in decreased expression of TFDP2 mRNA

NCBI chr 8:96,760,459...96,901,466
Ensembl chr 8:96,760,504...96,896,682

G

trefoil factor 1

increases expression

Ketoconazole results in increased expression of TFF1 mRNA

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

transforming growth factor, beta 3

decreases expression

Ketoconazole results in decreased expression of TGFB3 mRNA

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

transforming growth factor, beta receptor 1

decreases expression

Ketoconazole results in decreased expression of TGFBR1 mRNA

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

transforming growth factor, beta receptor 2

decreases expression

Ketoconazole results in decreased expression of TGFBR2 mRNA

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

tyrosine hydroxylase

multiple interactions

Ketoconazole inhibits the reaction [Maneb results in decreased expression of TH protein]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of TH protein]

PMID:19594327 PMID:22334051

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

translocase of inner mitochondrial membrane 10B

affects expression

Ketoconazole affects the expression of TIMM10B mRNA

NCBI chr 1:159,980,525...159,983,371
Ensembl chr 1:159,980,484...159,981,642

G

TIMP metallopeptidase inhibitor 1

decreases expression

Ketoconazole results in decreased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 4

increases expression

Ketoconazole results in increased expression of TIMP4 mRNA

NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558

G

tight junction protein 1

decreases expression

Ketoconazole results in decreased expression of TJP1 mRNA

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

transketolase

increases expression

Ketoconazole results in increased expression of TKT mRNA

NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698

G

transmembrane 7 superfamily member 3

decreases expression

Ketoconazole results in decreased expression of TM7SF3 mRNA

NCBI chr 4:179,518,127...179,550,154
Ensembl chr 4:179,518,130...179,550,154

G

transmembrane protein 106B

decreases expression

Ketoconazole results in decreased expression of TMEM106B mRNA

NCBI chr 4:41,328,125...41,347,315
Ensembl chr 4:41,327,994...41,345,619

G

transmembrane protein 18

decreases expression

Ketoconazole results in decreased expression of TMEM18 mRNA

NCBI chr 6:47,206,845...47,214,294
Ensembl chr 6:47,206,845...47,214,294

G

transmembrane protein 185B

increases expression

Ketoconazole results in increased expression of TMEM185B mRNA

NCBI chr13:30,647,533...30,650,864
Ensembl chr13:30,647,482...30,650,858

G

transmembrane protein 47

increases expression

Ketoconazole results in increased expression of TMEM47 mRNA

NCBI chr X:45,421,405...45,447,900
Ensembl chr X:45,421,405...45,447,900

G

transmembrane protein 54

affects expression

Ketoconazole affects the expression of TMEM54 mRNA

NCBI chr 5:141,449,191...141,455,683
Ensembl chr 5:141,449,191...141,455,682

G

thymosin, beta 10

decreases expression

Ketoconazole results in decreased expression of TMSB10 mRNA

NCBI chr 4:105,009,959...105,011,095
Ensembl chr 4:105,009,212...105,011,028

G

thymosin beta 4, X-linked

decreases expression

Ketoconazole results in decreased expression of TMSB4X mRNA

NCBI chr X:27,144,666...27,146,667
Ensembl chr X:27,128,610...27,146,667

G

transmembrane O-mannosyltransferase targeting cadherins 3

increases expression

Ketoconazole results in increased expression of TMTC3 mRNA

NCBI chr 7:35,264,886...35,310,010
Ensembl chr 7:35,264,892...35,310,385

G

tumor necrosis factor

increases expression
multiple interactions

Ketoconazole results in increased expression of TNF mRNA
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
Ketoconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]
AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Ketoconazole inhibits the reaction [Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNF protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; Ketoconazole promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]

PMID:11135059 PMID:12388057 PMID:15703382 PMID:16784723 PMID:21753779 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

increases expression

Ketoconazole results in increased expression of TNFRSF1A mRNA

PMID:25808816 PMID:36621641

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

increases expression

Ketoconazole results in increased expression of TNFRSF1B mRNA

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

TNF receptor superfamily member 9

decreases expression

Ketoconazole results in decreased expression of TNFRSF9 mRNA

NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000

G

TNF superfamily member 10

multiple interactions

Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNFSF10 protein]]

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

transportin 3

decreases expression

Ketoconazole results in decreased expression of TNPO3 mRNA

NCBI chr 4:58,142,954...58,220,365
Ensembl chr 4:58,143,001...58,220,433

G

tumor protein p63

decreases expression

Ketoconazole results in decreased expression of TRP63 mRNA

NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398

G

tumor protein p73

decreases expression

Ketoconazole results in decreased expression of TP73 mRNA

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128

G

two pore segment channel 1

increases expression

Ketoconazole results in increased expression of TPCN1 mRNA

NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626

G

tropomyosin 2

increases expression

Ketoconazole results in increased expression of TPM2 mRNA

NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992

G

thiopurine S-methyltransferase

decreases expression

Ketoconazole results in decreased expression of TPMT mRNA

NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709

G

tryptase beta 2

increases expression

Ketoconazole results in increased expression of TPSB2 mRNA

NCBI chr10:14,381,779...14,383,571
Ensembl chr10:14,382,013...14,383,569

G

transformer 2 beta

decreases expression

Ketoconazole results in decreased expression of TRA2B mRNA

NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249

G

TNF receptor associated factor 6

decreases expression

Ketoconazole results in decreased expression of TRAF6 mRNA

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

G

trafficking kinesin protein 2

increases expression

Ketoconazole results in increased expression of TRAK2 mRNA

NCBI chr 9:60,348,531...60,414,036
Ensembl chr 9:60,350,012...60,413,996

G

trafficking protein particle complex subunit 4

decreases expression

Ketoconazole results in decreased expression of TRAPPC4 mRNA

NCBI chr 8:44,729,458...44,733,285
Ensembl chr 8:44,725,331...44,733,491

G

transcriptional regulating factor 1

decreases expression

Ketoconazole results in decreased expression of TRERF1 mRNA

NCBI chr 9:13,631,619...13,858,326
Ensembl chr 9:13,634,126...13,857,029

G

tripartite motif-containing 23

affects expression

Ketoconazole affects the expression of TRIM23 mRNA

NCBI chr 2:35,302,405...35,335,746
Ensembl chr 2:35,302,409...35,335,743

G

thyroid stimulating hormone receptor

decreases expression

Ketoconazole results in decreased expression of TSHR mRNA

NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538

G

thymic stromal lymphopoietin

multiple interactions

4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

G

tetraspanin 15

decreases expression

Ketoconazole results in decreased expression of TSPAN15 mRNA

NCBI chr20:30,130,528...30,174,912
Ensembl chr20:30,130,530...30,174,930

G

tetraspanin 8

decreases expression

Ketoconazole results in decreased expression of TSPAN8 mRNA

NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356

G

tetratricopeptide repeat domain 39A

increases expression

Ketoconazole results in increased expression of TTC39A mRNA

NCBI chr 5:124,165,102...124,204,740
Ensembl chr 5:124,151,760...124,204,973

G

transcription termination factor 2

affects expression

Ketoconazole affects the expression of TTF2 mRNA

NCBI chr 2:188,366,321...188,397,750
Ensembl chr 2:188,366,331...188,397,689

G

terminal uridylyl transferase 7

increases expression

Ketoconazole results in increased expression of TUT7 mRNA

NCBI chr17:4,849,287...4,903,542
Ensembl chr17:4,849,283...4,903,169

G

taxilin gamma

increases expression

Ketoconazole results in increased expression of TXLNG mRNA

NCBI chr X:31,864,111...31,912,931
Ensembl chr X:31,864,111...31,912,926

G

ubiquitin A-52 residue ribosomal protein fusion product 1

affects expression

Ketoconazole affects the expression of UBA52 mRNA

NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807

G

ubiquitin-conjugating enzyme E2D 2B

increases expression

Ketoconazole results in increased expression of UBE2D4 mRNA

NCBI chr14:1,915,999...1,917,473
Ensembl chr14:1,916,845...1,917,416

G

UDP glucuronosyltransferase family 1 member A1

affects expression
decreases expression
decreases activity
multiple interactions

Ketoconazole affects the expression of UGT1A1 mRNA
Ketoconazole results in decreased expression of UGT1A1 mRNA
Ketoconazole results in decreased activity of UGT1A1 protein
[Ketoconazole results in decreased activity of UGT1A1 protein] which results in decreased metabolism of irinotecan

PMID:16608920 PMID:18355885 PMID:22447115 PMID:36893891

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member A1

affects expression

Ketoconazole affects the expression of UGT2A1 mRNA

NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531

G

UDP glucuronosyltransferase 2 family, polypeptide B1

affects expression

Ketoconazole affects the expression of UGT2B1 mRNA

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

ubiquitin specific peptidase 40

decreases expression

Ketoconazole results in decreased expression of USP40 mRNA

NCBI chr 9:88,607,920...88,678,940
Ensembl chr 9:88,607,930...88,678,914

G

vesicle-associated membrane protein 5

increases expression

Ketoconazole results in increased expression of VAMP5 mRNA

NCBI chr 4:104,423,813...104,435,059
Ensembl chr 4:104,423,820...104,426,212

G

vesicle-associated membrane protein 8

increases expression

Ketoconazole results in increased expression of VAMP8 mRNA

NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897

G

valosin containing protein lysine methyltransferase

increases expression

Ketoconazole results in increased expression of VCPKMT mRNA

NCBI chr 6:88,036,485...88,042,151
Ensembl chr 6:88,036,494...88,042,000

G

vitamin D receptor

multiple interactions

Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]; Ketoconazole inhibits the reaction [Vitamin D analog results in increased activity of VDR protein]

PMID:16280049 PMID:24792400

NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677

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vascular endothelial growth factor A

multiple interactions
decreases expression

Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]]; Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]
Ketoconazole results in decreased expression of VEGFA mRNA

PMID:21566342 PMID:37077353

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor B

increases expression

Ketoconazole results in increased expression of VEGFB mRNA

NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944

G

vestigial-like family member 3

decreases expression

Ketoconazole results in decreased expression of VGLL3 mRNA

NCBI chr11:3,642,993...3,692,590
Ensembl chr11:3,643,069...3,689,140

G

vestigial-like family member 4

decreases expression

Ketoconazole results in decreased expression of VGLL4 mRNA

NCBI chr 4:147,925,630...148,038,519
Ensembl chr 4:147,927,034...148,038,471

G

vimentin

affects expression

Ketoconazole affects the expression of VIM mRNA

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

very low density lipoprotein receptor

decreases expression

Ketoconazole results in decreased expression of VLDLR mRNA

NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920

G

ischemia related factor vof-16

increases expression

Ketoconazole results in increased expression of VOF16 mRNA

NCBI chr 8:41,953,062...41,955,169

G

WASP family member 3

increases expression

Ketoconazole results in increased expression of WASF3 mRNA

NCBI chr12:8,563,805...8,660,799
Ensembl chr12:8,562,062...8,660,751

G

WD repeat domain 17

increases expression

Ketoconazole results in increased expression of WDR17 mRNA

NCBI chr16:37,059,923...37,191,125
Ensembl chr16:37,059,895...37,191,122

G

WD repeat domain 26

increases expression

Ketoconazole results in increased expression of WDR26 mRNA

NCBI chr13:92,930,282...92,972,061
Ensembl chr13:92,930,285...92,977,295

G

WD repeat domain 43

increases expression

Ketoconazole results in increased expression of WDR43 mRNA

NCBI chr 6:23,845,499...23,884,846
Ensembl chr 6:23,845,499...23,884,846

G

WAS/WASL interacting protein family, member 1

decreases expression

Ketoconazole results in decreased expression of WIPF1 mRNA

NCBI chr 3:58,314,521...58,416,668
Ensembl chr 3:58,314,542...58,372,742

G

WD repeat domain, phosphoinositide interacting 1

increases expression

Ketoconazole results in increased expression of WIPI1 mRNA

PMID:15342952 PMID:17175557

NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846

G

WW domain containing transcription regulator 1

increases expression

Ketoconazole results in increased expression of WWTR1 mRNA

NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968

G

exportin for tRNA

decreases expression

Ketoconazole results in decreased expression of XPOT mRNA

NCBI chr 7:57,111,536...57,152,013
Ensembl chr 7:57,111,536...57,152,099

G

xylosyltransferase 1

decreases expression

Ketoconazole results in decreased expression of XYLT1 mRNA

NCBI chr 1:171,643,925...171,929,774
Ensembl chr 1:171,643,925...171,926,783

G

YEATS domain containing 4

increases expression

Ketoconazole results in increased expression of YEATS4 mRNA

NCBI chr 7:52,858,313...52,865,454
Ensembl chr 7:52,858,305...52,865,635

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

increases expression

Ketoconazole results in increased expression of YWHAE mRNA

NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589

G

zygote arrest 1

decreases expression

Ketoconazole results in decreased expression of ZAR1 mRNA

NCBI chr14:35,193,446...35,197,382
Ensembl chr14:35,193,446...35,197,382

G

zinc finger protein 451

increases expression

Ketoconazole results in increased expression of ZFP451 mRNA

NCBI chr 9:35,985,441...36,040,991
Ensembl chr 9:35,985,443...36,040,652

G

zinc finger protein 518B

increases expression

Ketoconazole results in increased expression of ZNF518B mRNA

NCBI chr14:72,121,085...72,140,479
Ensembl chr14:72,121,112...72,140,481

G

zinc finger protein 703

decreases expression

Ketoconazole results in decreased expression of ZFP703 mRNA

NCBI chr16:65,076,507...65,080,677
Ensembl chr16:65,076,507...65,080,677

G

zinc finger protein 709-like 1

decreases expression

Ketoconazole results in decreased expression of ZFP709L1 mRNA

NCBI chr 7:7,683,807...7,708,257
Ensembl chr 7:7,668,997...7,780,109

G

zinc finger, SWIM-type containing 6

increases expression

Ketoconazole results in increased expression of ZSWIM6 mRNA

NCBI chr 2:39,211,131...39,378,877
Ensembl chr 2:39,212,949...39,378,924

miconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetoacetyl-CoA synthetase

increases expression

Miconazole results in increased expression of AACS mRNA

NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954

G

ATP binding cassette subfamily A member 1

decreases expression

Miconazole results in decreased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

multiple interactions

Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]
Miconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

acetyl-CoA carboxylase alpha

increases expression

Miconazole results in increased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

ATP citrate lyase

increases expression

Miconazole results in increased expression of ACLY mRNA

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

aconitase 1

increases expression

Miconazole results in increased expression of ACO1 mRNA

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

acyl-CoA synthetase bubblegum family member 1

increases expression

Miconazole results in increased expression of ACSBG1 mRNA

NCBI chr 8:54,991,294...55,047,276
Ensembl chr 8:54,991,296...55,047,391

G

acyl-CoA synthetase short-chain family member 2

increases expression

Miconazole results in increased expression of ACSS2 mRNA

NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675

G

ADAM metallopeptidase domain 9

decreases expression
increases expression

Miconazole results in decreased expression of ADAM9 mRNA
Miconazole results in increased expression of ADAM9 mRNA

NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917

G

adenylate cyclase 2

decreases activity

Miconazole results in decreased activity of ADCY2 protein

NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236

G

adenylate cyclase 9

multiple interactions
increases activity

[Isoproterenol co-treated with Miconazole] results in increased activity of ADCY9 protein alternative form; Calcium inhibits the reaction [Miconazole results in increased activity of ADCY9 protein]; Tacrolimus inhibits the reaction [Calcium inhibits the reaction [Miconazole results in increased activity of ADCY9 protein]]
[Colforsin co-treated with Miconazole] results in increased activity of ADCY9 protein
Miconazole results in increased activity of ADCY9 protein; Miconazole results in increased activity of ADCY9 protein alternative form

NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066

G

AKT serine/threonine kinase 1

decreases phosphorylation

Miconazole results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

activated leukocyte cell adhesion molecule

decreases expression

Miconazole results in decreased expression of ALCAM mRNA

NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954

G

aldehyde dehydrogenase 1 family, member A1

increases expression

Miconazole results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

anaphase promoting complex subunit 16

increases expression

Miconazole results in increased expression of ANAPC16 mRNA

NCBI chr20:27,927,334...27,941,644
Ensembl chr20:27,927,334...27,941,984

G

ankyrin repeat domain 10

decreases expression

Miconazole results in decreased expression of ANKRD10 mRNA

NCBI chr16:77,866,489...77,889,745
Ensembl chr16:77,864,261...77,889,745

G

ankyrin repeat domain 12

decreases expression

Miconazole results in decreased expression of ANKRD12 mRNA

NCBI chr 9:105,583,273...105,687,957
Ensembl chr 9:105,584,065...105,687,911

G

anoctamin 8

decreases expression

Miconazole results in decreased expression of ANO8 mRNA

NCBI chr16:18,163,853...18,173,248
Ensembl chr16:18,163,843...18,173,545

G

annexin A1

decreases expression

Miconazole results in decreased expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

APC regulator of WNT signaling pathway

decreases expression

Miconazole results in decreased expression of APC mRNA

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

apurinic/apyrimidinic endodeoxyribonuclease 1

decreases expression

Miconazole results in decreased expression of APEX1 mRNA

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

ADP-ribosylation factor 3

increases expression

Miconazole results in increased expression of ARF3 mRNA

NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002

G

ADP ribosylation factor guanine nucleotide exchange factor 1

decreases expression

Miconazole results in decreased expression of ARFGEF1 mRNA

NCBI chr 5:8,982,061...9,076,326
Ensembl chr 5:8,981,540...9,076,326

G

Rho GTPase activating protein 5

decreases expression

Miconazole results in decreased expression of ARHGAP5 mRNA

NCBI chr 6:69,975,904...70,039,299
Ensembl chr 6:69,976,214...70,037,660

G

arkadia C-terminal like ring finger ubiquitin ligase 2C

decreases expression

Miconazole results in decreased expression of ARK2C mRNA

NCBI chr18:70,984,566...71,100,836
Ensembl chr18:70,989,731...71,100,836

G

ADP-ribosylation factor like GTPase 2 binding protein

decreases expression

Miconazole results in decreased expression of ARL2BP mRNA

NCBI chr19:10,336,921...10,346,555
Ensembl chr19:10,336,921...10,346,564

G

ADP-ribosylation factor like GTPase 5A

decreases expression

Miconazole results in decreased expression of ARL5A mRNA

NCBI chr 3:36,878,461...36,903,362
Ensembl chr 3:36,880,712...36,903,211

G

ADP-ribosylation factor like GTPase 6 interacting protein 1

increases expression

Miconazole results in increased expression of ARL6IP1 mRNA

NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994

G

ASH1 like histone lysine methyltransferase

decreases expression

Miconazole results in decreased expression of ASH1L mRNA

NCBI chr 2:174,346,267...174,483,057
Ensembl chr 2:174,346,150...174,483,055

G

ATPase plasma membrane Ca2+ transporting 1

decreases expression

Miconazole results in decreased expression of ATP2B1 mRNA

NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295

G

ATPase H+ transporting V0 subunit C

increases expression

Miconazole results in increased expression of ATP6V0C mRNA

NCBI chr10:13,196,204...13,202,580
Ensembl chr10:13,196,204...13,201,500

G

ATPase H+ transporting V1 subunit G1

increases expression

Miconazole results in increased expression of ATP6V1G1 mRNA

NCBI chr 5:76,961,462...76,967,642
Ensembl chr 5:76,961,499...76,969,463

G

ATR serine/threonine kinase

decreases expression

Miconazole results in decreased expression of ATR mRNA

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

ATRX, chromatin remodeler

decreases expression

Miconazole results in decreased expression of ATRX mRNA

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

aurora kinase B

increases expression

Miconazole results in increased expression of AURKB mRNA

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

baculoviral IAP repeat-containing 5

increases expression

Miconazole results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein receptor type 2

decreases expression

Miconazole results in decreased expression of BMPR2 mRNA

NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809

G

B-Raf proto-oncogene, serine/threonine kinase

decreases expression

Miconazole results in decreased expression of BRAF mRNA

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

bromodomain containing 9

increases expression

Miconazole results in increased expression of BRD9 mRNA

NCBI chr 1:29,329,981...29,357,285
Ensembl chr 1:29,329,985...29,357,016

G

bromodomain and WD repeat domain containing 3

decreases expression

Miconazole results in decreased expression of BRWD3 mRNA

NCBI chr X:73,768,343...73,861,643
Ensembl chr X:73,774,340...73,861,622

G

bassoon (presynaptic cytomatrix protein)

increases expression

Miconazole results in increased expression of BSN mRNA

NCBI chr 8:108,784,849...108,875,819
Ensembl chr 8:108,788,542...108,875,819

G

BTG anti-proliferation factor 1

decreases expression

Miconazole results in decreased expression of BTG1 mRNA

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

calcitonin receptor like receptor

decreases expression

Miconazole results in decreased expression of CALCRL mRNA

NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910

G

calcium/calmodulin-dependent protein kinase I

decreases expression

Miconazole results in decreased expression of CAMK1 mRNA

NCBI chr 4:146,481,196...146,492,039
Ensembl chr 4:146,481,196...146,492,081

G

caspase 3

multiple interactions

[3-methyladenine co-treated with Miconazole] results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

decreases expression

Miconazole results in decreased expression of CASP6 mRNA

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

catalase

decreases expression

Miconazole results in decreased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cell division cycle and apoptosis regulator 1

decreases expression

Miconazole results in decreased expression of CCAR1 mRNA

NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526

G

coiled coil domain containing 88A

decreases expression

Miconazole results in decreased expression of CCDC88A mRNA

NCBI chr14:103,104,091...103,256,112
Ensembl chr14:103,103,513...103,252,368

G

cyclin G1

decreases expression

Miconazole results in decreased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cyclin L2

decreases expression

Miconazole results in decreased expression of CCNL2 mRNA

NCBI chr 5:166,416,940...166,428,997
Ensembl chr 5:166,417,508...166,436,882

G

cyclin T2

decreases expression

Miconazole results in decreased expression of CCNT2 mRNA

NCBI chr13:39,251,573...39,293,172
Ensembl chr13:39,251,573...39,292,019

G

chaperonin containing TCP1 subunit 3

increases expression

Miconazole results in increased expression of CCT3 mRNA

NCBI chr 2:173,765,701...173,790,353
Ensembl chr 2:173,765,698...173,790,757

G

chaperonin containing TCP1 subunit 5

increases expression

Miconazole results in increased expression of CCT5 mRNA

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

chaperonin containing TCP1 subunit 8

increases expression

Miconazole results in increased expression of CCT8 mRNA

NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079

G

cell division cycle associated 2

increases expression

Miconazole results in increased expression of CDCA2 mRNA

NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611

G

cyclin-dependent kinase 4

increases expression

Miconazole results in increased expression of CDK4 mRNA

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

centromere protein E

decreases expression

Miconazole results in decreased expression of CENPE mRNA

NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669

G

centromere protein F

decreases expression

Miconazole results in decreased expression of CENPF mRNA

NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669

G

cofilin 1

increases expression

Miconazole results in increased expression of CFL1 mRNA

NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587

G

coiled-coil-helix-coiled-coil-helix domain containing 2

increases expression

Miconazole results in increased expression of CHCHD2 mRNA

NCBI chr12:26,828,738...26,834,762
Ensembl chr12:26,828,736...26,834,755

G

chromodomain helicase DNA binding protein 1

decreases expression

Miconazole results in decreased expression of CHD1 mRNA

NCBI chr 1:56,661,743...56,729,119
Ensembl chr 1:56,664,054...56,728,125

G

CHM like Rab escort protein

decreases expression

Miconazole results in decreased expression of CHML mRNA

NCBI chr13:87,609,647...87,619,868
Ensembl chr13:87,589,298...87,619,862

G

charged multivesicular body protein 4B

increases expression

Miconazole results in increased expression of CHMP4B mRNA

NCBI chr 3:143,170,859...143,211,376
Ensembl chr 3:143,170,902...143,210,844

G

choline phosphotransferase 1

decreases expression

Miconazole results in decreased expression of CHPT1 mRNA

NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103

G

chromosome transmission fidelity factor 18

increases expression

Miconazole results in increased expression of CHTF18 mRNA

NCBI chr10:14,743,006...14,751,044
Ensembl chr10:14,742,621...14,751,050

G

CDC-like kinase 1

decreases expression

Miconazole results in decreased expression of CLK1 mRNA

NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000

G

collagen type I alpha 1 chain

decreases expression

Miconazole results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type V alpha 1 chain

decreases expression

Miconazole results in decreased expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

COPI coat complex subunit beta 2

increases expression

Miconazole results in increased expression of COPB2 mRNA

NCBI chr 8:99,161,324...99,183,452
Ensembl chr 8:99,161,350...99,185,197

G

cleavage and polyadenylation specific factor 6

decreases expression

Miconazole results in decreased expression of CPSF6 mRNA

NCBI chr 7:52,956,589...53,001,783
Ensembl chr 7:52,956,589...52,988,122

G

cramped chromatin regulator homolog 1

decreases expression

Miconazole results in decreased expression of CRAMP1 mRNA

NCBI chr10:13,983,781...14,032,409
Ensembl chr10:13,983,866...14,032,392

G

CREB3 regulatory factor

decreases expression

Miconazole results in decreased expression of CREBRF mRNA

NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999

G

cytokine receptor-like factor 1

decreases expression

Miconazole results in decreased expression of CRLF1 mRNA

NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,924,722...18,935,997

G

citrate synthase

increases expression

Miconazole results in increased expression of CS mRNA

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

casein kinase 1, alpha 1

decreases expression

Miconazole results in decreased expression of CSNK1A1 mRNA

NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271

G

cathepsin D

increases expression

Miconazole results in increased expression of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cortactin binding protein 2

decreases expression

Miconazole results in decreased expression of CTTNBP2 mRNA

NCBI chr 4:46,800,975...46,964,681
Ensembl chr 4:46,800,981...46,964,631

G

CWF19 like cell cycle control factor 2

decreases expression

Miconazole results in decreased expression of CWF19L2 mRNA

NCBI chr 6:290,148...356,636
Ensembl chr 6:281,685...356,604

G

C-X-C motif chemokine receptor 4

increases expression

Miconazole results in increased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome b5 type B

increases expression

Miconazole results in increased expression of CYB5B mRNA

NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249

G

cytochrome c, somatic

decreases expression

Miconazole results in decreased expression of CYCS mRNA

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity

Miconazole results in decreased activity of CYP17A1 protein

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

Miconazole results in decreased activity of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases expression

Miconazole results in decreased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

Miconazole results in increased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily a, polypeptide 1

multiple interactions

Miconazole inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

Miconazole results in decreased activity of CYP2C19 protein

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases expression
decreases activity

Miconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Miconazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]
Miconazole results in increased expression of CYP3A4 mRNA
Miconazole results in decreased activity of CYP3A4 protein

PMID:15135088 PMID:15969931 PMID:17998298 PMID:19299527

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

Miconazole results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 51

decreases activity
increases expression
decreases response to substance

Miconazole results in decreased activity of CYP51A1 protein
Miconazole results in increased expression of CYP51 mRNA
CYP51A1 gene results in decreased susceptibility to Miconazole

PMID:16989930 PMID:18694951 PMID:27462272 PMID:29337257

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

dihydrolipoamide branched chain transacylase E2

decreases expression

Miconazole results in decreased expression of DBT mRNA

NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609

G

DDB1 and CUL4 associated factor 7

increases expression

Miconazole results in increased expression of DCAF7 mRNA

NCBI chr10:90,974,095...90,996,275
Ensembl chr10:90,974,095...90,996,275

G

DCC netrin 1 receptor

decreases expression

Miconazole results in decreased expression of DCC mRNA

NCBI chr18:64,868,987...65,972,783
Ensembl chr18:64,873,898...65,972,740

G

deoxycytidine kinase

increases expression

Miconazole results in increased expression of DCK mRNA

NCBI chr14:19,305,218...19,326,247
Ensembl chr14:19,305,218...19,326,247

G

damage-specific DNA binding protein 1

increases expression

Miconazole results in increased expression of DDB1 mRNA

NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676

G

DEAD-box helicase 5

decreases expression

Miconazole results in decreased expression of DDX5 mRNA

NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283

G

DEAD-box helicase 59

increases expression

Miconazole results in increased expression of DDX59 mRNA

NCBI chr13:47,876,258...47,901,214
Ensembl chr13:47,876,261...47,901,214

G

24-dehydrocholesterol reductase

increases expression

Miconazole results in increased expression of DHCR24 mRNA

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

7-dehydrocholesterol reductase

increases expression

Miconazole results in increased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

dehydrogenase/reductase 3

increases expression

Miconazole results in increased expression of DHRS3 mRNA

NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417

G

DEAH-box helicase 36

decreases expression

Miconazole results in decreased expression of DHX36 mRNA

NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572

G

Dmx-like 1

decreases expression

Miconazole results in decreased expression of DMXL1 mRNA

NCBI chr18:42,993,292...43,163,457
Ensembl chr18:42,993,340...43,163,456

G

DnaJ heat shock protein family (Hsp40) member C10

decreases expression

Miconazole results in decreased expression of DNAJC10 mRNA

NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719

G

dedicator of cytokinesis 10

decreases expression

Miconazole results in decreased expression of DOCK10 mRNA

NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525

G

dedicator of cytokinesis 11

decreases expression

Miconazole results in decreased expression of DOCK11 mRNA

NCBI chr X:115,131,720...115,314,854
Ensembl chr X:115,131,909...115,314,854

G

diphthamide biosynthesis 7

increases expression

Miconazole results in increased expression of DPH7 mRNA

NCBI chr 3:7,770,368...7,778,994
Ensembl chr 3:7,770,379...7,778,982

G

dipeptidylpeptidase 8

decreases expression

Miconazole results in decreased expression of DPP8 mRNA

NCBI chr 8:65,550,620...65,605,828
Ensembl chr 8:65,550,677...65,605,825

G

dihydropyrimidinase-like 2

increases expression

Miconazole results in increased expression of DPYSL2 mRNA

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

G

dopamine receptor D5

increases expression

Miconazole results in increased expression of DRD5 mRNA

NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774

G

dual specificity phosphatase 1

increases expression

Miconazole results in increased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dynein cytoplasmic 1 heavy chain 1

increases expression

Miconazole results in increased expression of DYNC1H1 mRNA

NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883

G

dynein light chain Tctex-type 1

increases expression

Miconazole results in increased expression of DYNLT1B mRNA

NCBI chr 1:46,887,017...46,893,956
Ensembl chr 1:46,887,017...46,893,881

G

dynein light chain Tctex-type 3

decreases expression

Miconazole results in decreased expression of DYNLT3 mRNA

NCBI chr X:13,327,933...13,337,139
Ensembl chr X:13,327,892...13,337,139

G

DAZ interacting zinc finger protein 3

decreases expression

Miconazole results in decreased expression of DZIP3 mRNA

NCBI chr11:51,823,235...51,893,353
Ensembl chr11:51,823,231...51,893,353

G

early endosome antigen 1

decreases expression

Miconazole results in decreased expression of EEA1 mRNA

NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487

G

eukaryotic translation elongation factor 1 alpha 1

increases expression

Miconazole results in increased expression of EEF1A1 mRNA

NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839

G

eukaryotic translation elongation factor 1 beta 2

increases expression

Miconazole results in increased expression of EEF1B2 mRNA

NCBI chr 9:64,580,163...64,582,737
Ensembl chr 9:64,579,893...64,582,737

G

early growth response 1

increases expression

Miconazole results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 3, subunit A

decreases expression

Miconazole results in decreased expression of EIF3A mRNA

NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976

G

eukaryotic translation initiation factor 3, subunit C

increases expression

Miconazole results in increased expression of EIF3C mRNA

NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493

G

eukaryotic translation initiation factor 5B

decreases expression

Miconazole results in decreased expression of EIF5B mRNA

NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482

G

ELOVL fatty acid elongase 5

increases expression

Miconazole results in increased expression of ELOVL5 mRNA

NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284

G

elongator acetyltransferase complex subunit 2

increases expression

Miconazole results in increased expression of ELP2 mRNA

NCBI chr18:15,885,940...15,921,564
Ensembl chr18:15,885,934...15,921,599

G

E1A binding protein p300

decreases expression

Miconazole results in decreased expression of EP300 mRNA

PMID:22262564 PMID:27462272

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

EPH receptor A5

decreases expression

Miconazole results in decreased expression of EPHA5 mRNA

NCBI chr14:23,653,393...24,020,129
Ensembl chr14:23,653,393...24,017,317

G

erb-b2 receptor tyrosine kinase 4

increases expression
decreases expression

Miconazole results in increased expression of ERBB4 mRNA
Miconazole results in decreased expression of ERBB4 mRNA

PMID:22262564 PMID:27462272

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

ergosterol biosynthesis 28 homolog

increases expression

Miconazole results in increased expression of ERG28 mRNA

NCBI chr 6:105,474,112...105,483,078
Ensembl chr 6:105,474,113...105,483,078

G

ESF1 nucleolar pre-rRNA processing protein homolog

decreases expression

Miconazole results in decreased expression of ESF1 mRNA

NCBI chr 3:127,454,744...127,507,941
Ensembl chr 3:127,454,811...127,507,817

G

ethanolamine kinase 1

decreases expression

Miconazole results in decreased expression of ETNK1 mRNA

NCBI chr 4:176,126,056...176,170,325
Ensembl chr 4:176,126,180...176,193,770

G

exonuclease 1

increases expression

Miconazole results in increased expression of EXO1 mRNA

NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654

G

exocyst complex component 5

decreases expression

Miconazole results in decreased expression of EXOC5 mRNA

NCBI chr15:22,310,682...22,355,695
Ensembl chr15:22,308,946...22,355,335

G

fatty acid binding protein 7

decreases expression

Miconazole results in decreased expression of FABP7 mRNA

NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880

G

fatty acid desaturase 1

increases expression

Miconazole results in increased expression of FADS1 mRNA

NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734

G

fatty acid desaturase 2

increases expression

Miconazole results in increased expression of FADS2 mRNA

NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789

G

family with sequence similarity 199, X-linked

decreases expression

Miconazole results in decreased expression of FAM199X mRNA

NCBI chr X:100,384,230...100,419,935
Ensembl chr X:100,384,225...100,414,938

G

FA complementation group M

decreases expression

Miconazole results in decreased expression of FANCM mRNA

NCBI chr 6:83,126,903...83,180,455
Ensembl chr 6:83,127,093...83,180,028

G

fatty acyl CoA reductase 1

decreases expression

Miconazole results in decreased expression of FAR1 mRNA

NCBI chr 1:167,644,622...167,705,868
Ensembl chr 1:167,644,677...167,705,730

G

fatty acid synthase

increases expression

Miconazole results in increased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibrillarin

increases expression

Miconazole results in increased expression of FBL mRNA

NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932

G

fibrillin 2

increases expression

Miconazole results in increased expression of FBN2 mRNA

NCBI chr18:51,499,670...51,703,976
Ensembl chr18:51,499,737...51,703,976

G

farnesyl diphosphate farnesyl transferase 1

increases expression

Miconazole results in increased expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

farnesyl diphosphate synthase

increases expression

Miconazole results in increased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

fibroblast growth factor binding protein 3

increases expression

Miconazole results in increased expression of FGFBP3 mRNA

NCBI chr 1:234,644,023...234,646,028
Ensembl chr 1:234,644,019...234,646,547

G

fidgetin-like 2

decreases expression

Miconazole results in decreased expression of FIGNL2 mRNA

NCBI chr 7:132,160,006...132,187,896
Ensembl chr 7:132,162,390...132,164,336

G

FKBP prolyl isomerase 4

increases expression

Miconazole results in increased expression of FKBP4 mRNA

NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833

G

folliculin interacting protein 1

decreases expression

Miconazole results in decreased expression of FNIP1 mRNA

NCBI chr10:38,567,728...38,650,824
Ensembl chr10:38,567,729...38,650,824

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Miconazole results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 1, AP-1 transcription factor subunit

decreases expression

Miconazole results in decreased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box M1

increases expression

Miconazole results in increased expression of FOXM1 mRNA

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

G

ferritin heavy chain 1

increases expression

Miconazole results in increased expression of FTH1 mRNA

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

far upstream element binding protein 1

decreases expression

Miconazole results in decreased expression of FUBP1 mRNA

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G

frizzled class receptor 3

decreases expression

Miconazole results in decreased expression of FZD3 mRNA

NCBI chr15:39,421,366...39,488,369
Ensembl chr15:39,421,355...39,488,369

G

growth arrest and DNA-damage-inducible, gamma

increases expression

Miconazole results in increased expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

galactokinase 1

increases expression

Miconazole results in increased expression of GALK1 mRNA

NCBI chr10:101,243,146...101,247,323
Ensembl chr10:101,235,994...101,247,337

G

gamma-glutamyl cyclotransferase

increases expression

Miconazole results in increased expression of GGCT mRNA

NCBI chr 4:84,122,921...84,129,327
Ensembl chr 4:84,123,118...84,129,277

G

GINS complex subunit 2

increases expression

Miconazole results in increased expression of GINS2 mRNA

NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339

G

GLI family zinc finger 3

increases expression

Miconazole results in increased expression of GLI3 mRNA

NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712

G

glutamate-ammonia ligase

increases expression

Miconazole results in increased expression of GLUL mRNA

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

golgin A7

increases expression

Miconazole results in increased expression of GOLGA7 mRNA

NCBI chr16:68,767,259...68,782,536
Ensembl chr16:68,767,299...68,782,511

G

glycoprotein m6b

decreases expression

Miconazole results in decreased expression of GPM6B mRNA

NCBI chr X:28,057,788...28,204,409
Ensembl chr X:28,059,450...28,204,211

G

glutamate ionotropic receptor AMPA type subunit 2

decreases expression

Miconazole results in decreased expression of GRIA2 mRNA

NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510

G

glutathione S-transferase alpha 2

increases expression

Miconazole results in increased expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

general transcription factor IIF subunit 1

increases expression

Miconazole results in increased expression of GTF2F1 mRNA

NCBI chr 9:1,844,027...1,853,455
Ensembl chr 9:1,843,901...1,853,423

G

H2A.X variant histone

increases expression

Miconazole results in increased expression of H2AX mRNA

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

histone deacetylase 6

increases expression

Miconazole results in increased expression of HDAC6 mRNA

NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441

G

hypoxia inducible factor 1 subunit alpha

decreases expression

Miconazole results in decreased expression of HIF1A mRNA

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

high mobility group box 2

increases expression

Miconazole results in increased expression of HMGB2 mRNA

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression

Miconazole results in increased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

Miconazole results in increased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

high mobility group nucleosome binding domain 1

increases expression

Miconazole results in increased expression of HMGN1 mRNA

NCBI chr11:35,422,328...35,428,247
Ensembl chr11:35,422,328...35,428,254

G

heme oxygenase 2

decreases expression

Miconazole results in decreased expression of HMOX2 mRNA

NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148

G

heterogeneous nuclear ribonucleoprotein A2/B1

decreases expression

Miconazole results in decreased expression of HNRNPA2B1 mRNA

NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249

G

hook microtubule-tethering protein 3

decreases expression

Miconazole results in decreased expression of HOOK3 mRNA

NCBI chr16:65,954,293...66,058,812
Ensembl chr16:65,954,350...66,061,338

G

heat shock factor binding protein 1

increases expression

Miconazole results in increased expression of HSBP1 mRNA

NCBI chr19:47,401,039...47,405,373
Ensembl chr19:47,400,966...47,435,821

G

hydroxysteroid (17-beta) dehydrogenase 7

increases expression

Miconazole results in increased expression of HSD17B7 mRNA

NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017

G

heat shock protein 90 alpha family class B member 1

increases expression

Miconazole results in increased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family D (Hsp60) member 1

decreases expression

Miconazole results in decreased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heparan sulfate proteoglycan 2

decreases expression

Miconazole results in decreased expression of HSPG2 mRNA

NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594

G

isopentenyl-diphosphate delta isomerase 1

increases expression

Miconazole results in increased expression of IDI1 mRNA

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

iduronate 2-sulfatase

decreases expression

Miconazole results in decreased expression of IDS mRNA

NCBI chr X:149,025,976...149,046,641
Ensembl chr X:149,025,976...149,046,663

G

interferon induced transmembrane protein 2

increases expression

Miconazole results in increased expression of IFITM2 mRNA

NCBI chr 1:196,051,539...196,052,719
Ensembl chr 1:196,051,537...196,052,741

G

IgA-inducing protein

decreases expression

Miconazole results in decreased expression of IGIP mRNA

NCBI chr18:27,904,018...27,905,509

G

interleukin 4

multiple interactions
decreases secretion
decreases expression

1-Methyl-3-isobutylxanthine inhibits the reaction [Miconazole results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Miconazole results in decreased secretion of IL4 protein]; Bucladesine inhibits the reaction [Miconazole results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Miconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Miconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Miconazole results in decreased secretion of IL4 protein]

PMID:11886533 PMID:15284827

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

multiple interactions
decreases expression
decreases secretion

1-Methyl-3-isobutylxanthine inhibits the reaction [Miconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Miconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Miconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Miconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Miconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Miconazole results in decreased secretion of IL5 protein]

PMID:11886533 PMID:15284827

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

inosine monophosphate dehydrogenase 2

increases expression

Miconazole results in increased expression of IMPDH2 mRNA

NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359

G

insulin induced gene 1

increases expression

Miconazole results in increased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

insulin receptor

decreases expression

Miconazole results in decreased expression of INSR mRNA

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

integrator complex subunit 6 like

decreases expression

Miconazole results in decreased expression of INTS6L mRNA

NCBI chr X:134,258,117...134,325,706
Ensembl chr X:134,258,125...134,309,617

G

importin 5

increases expression

Miconazole results in increased expression of IPO5 mRNA

NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126

G

iron responsive element binding protein 2

decreases expression

Miconazole results in decreased expression of IREB2 mRNA

NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611

G

Jupiter microtubule associated homolog 2

increases expression

Miconazole results in increased expression of JPT2 mRNA

NCBI chr10:13,963,135...13,983,212
Ensembl chr10:13,963,137...13,983,170

G

JRK-like

decreases expression

Miconazole results in decreased expression of JRKL mRNA

NCBI chr 8:10,224,172...10,227,068
Ensembl chr 8:10,224,172...10,227,068

G

potassium voltage-gated channel subfamily D member 2

decreases expression

Miconazole results in decreased expression of KCND2 mRNA

NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Miconazole results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

KH RNA binding domain containing, signal transduction associated 1

decreases expression

Miconazole results in decreased expression of KHDRBS1 mRNA

NCBI chr 5:142,051,844...142,089,175
Ensembl chr 5:142,063,570...142,089,180

G

KH-type splicing regulatory protein

decreases expression

Miconazole results in decreased expression of KHSRP mRNA

NCBI chr 9:1,862,555...1,872,403
Ensembl chr 9:1,862,899...1,872,451

G

kinesin family member 5B

decreases expression

Miconazole results in decreased expression of KIF5B mRNA

NCBI chr17:51,489,904...51,527,508
Ensembl chr17:51,489,944...51,527,508

G

kelch-like family member 24

decreases expression

Miconazole results in decreased expression of KLHL24 mRNA

NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636

G

lysine methyltransferase 2D

decreases expression

Miconazole results in decreased expression of KMT2D mRNA

NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325

G

kaptin (actin binding protein)

increases expression

Miconazole results in increased expression of KPTN mRNA

NCBI chr 1:76,808,737...76,809,531

G

laminin subunit beta 1

increases expression

Miconazole results in increased expression of LAMB1 mRNA

NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585

G

leucyl-tRNA synthetase 2, mitochondrial

decreases expression

Miconazole results in decreased expression of LARS2 mRNA

NCBI chr 8:123,010,271...123,106,395
Ensembl chr 8:123,010,293...123,106,395

G

LIM and SH3 protein 1

increases expression

Miconazole results in increased expression of LASP1 mRNA

NCBI chr10:82,795,177...82,835,659
Ensembl chr10:82,795,137...82,943,292

G

leukocyte receptor cluster member 8

decreases expression

Miconazole results in decreased expression of LENG8 mRNA

NCBI chr 1:70,040,785...70,052,662
Ensembl chr 1:70,040,785...70,052,488

G

DNA ligase 1

decreases expression

Miconazole results in decreased expression of LIG1 mRNA

NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413

G

DNA ligase 3

increases expression

Miconazole results in increased expression of LIG3 mRNA

NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414

G

lin-7 homolog C, crumbs cell polarity complex component

decreases expression

Miconazole results in decreased expression of LIN7C mRNA

NCBI chr 3:96,406,800...96,417,779
Ensembl chr 3:96,406,813...96,417,728

G

lines homolog 1

decreases expression

Miconazole results in decreased expression of LINS1 mRNA

NCBI chr 1:120,267,586...120,295,013
Ensembl chr 1:120,267,693...120,293,607

G

lemur tyrosine kinase 2

decreases expression

Miconazole results in decreased expression of LMTK2 mRNA

NCBI chr12:10,426,772...10,508,750
Ensembl chr12:10,426,777...10,508,750

G

lysophosphatidic acid receptor 4

decreases expression

Miconazole results in decreased expression of LPAR4 mRNA

NCBI chr X:72,033,486...72,046,978
Ensembl chr X:72,033,486...72,046,977

G

leucine rich repeats and calponin homology domain containing 2

decreases expression

Miconazole results in decreased expression of LRCH2 mRNA

NCBI chr X:111,091,728...111,174,225
Ensembl chr X:111,092,814...111,174,210

G

LDL receptor related protein 1

decreases expression

Miconazole results in decreased expression of LRP1 mRNA

NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910

G

leucine rich repeat containing 58

decreases expression

Miconazole results in decreased expression of LRRC58 mRNA

NCBI chr11:62,850,507...62,862,829
Ensembl chr11:62,847,562...62,862,829

G

leucine rich repeat transmembrane neuronal 2

decreases expression

Miconazole results in decreased expression of LRRTM2 mRNA

NCBI chr18:26,817,816...26,822,864
Ensembl chr18:26,817,816...26,822,864

G

LUC7-like 3 pre-mRNA splicing factor

decreases expression

Miconazole results in decreased expression of LUC7L3 mRNA

NCBI chr10:79,240,050...79,276,555
Ensembl chr10:79,240,563...79,276,538

G

leucine zipper protein 2

decreases expression

Miconazole results in decreased expression of LUZP2 mRNA

NCBI chr 1:105,597,291...105,983,605
Ensembl chr 1:105,597,307...105,981,183

G

mannosidase, endo-alpha

decreases expression

Miconazole results in decreased expression of MANEA mRNA

NCBI chr 5:40,196,373...40,218,540
Ensembl chr 5:40,196,396...40,218,459

G

microtubule-associated protein 1B

decreases expression

Miconazole results in decreased expression of MAP1B mRNA

NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases lipidation

[bafilomycin A1 co-treated with Miconazole] results in increased expression of MAP1LC3B protein; bafilomycin A1 promotes the reaction [Miconazole results in increased lipidation of MAP1LC3B protein]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

microtubule-associated protein 2

decreases expression

Miconazole results in decreased expression of MAP2 mRNA

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase kinase kinase 2

decreases expression

Miconazole results in decreased expression of MAP3K2 mRNA

NCBI chr18:23,807,218...23,879,722
Ensembl chr18:23,807,218...23,871,433

G

mitogen-activated protein kinase 8

increases expression

Miconazole results in increased expression of MAPK8 mRNA

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

muscleblind-like splicing regulator 2

decreases expression

Miconazole results in decreased expression of MBNL2 mRNA

NCBI chr15:97,385,278...97,542,924
Ensembl chr15:97,385,244...97,542,937

G

minichromosome maintenance complex component 3

increases expression

Miconazole results in increased expression of MCM3 mRNA

NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314

G

minichromosome maintenance complex component 7

increases expression

Miconazole results in increased expression of MCM7 mRNA

NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063

G

mediator of DNA damage checkpoint 1

increases expression

Miconazole results in increased expression of MDC1 mRNA

NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240

G

malate dehydrogenase 1

increases expression

Miconazole results in increased expression of MDH1 mRNA

NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925

G

mediator complex subunit 13

decreases expression

Miconazole results in decreased expression of MED13 mRNA

NCBI chr10:71,086,978...71,176,535
Ensembl chr10:71,090,516...71,177,242

G

O-6-methylguanine-DNA methyltransferase

decreases expression

Miconazole results in decreased expression of MGMT mRNA

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

MIA SH3 domain ER export factor 3

decreases expression

Miconazole results in decreased expression of MIA3 mRNA

NCBI chr13:94,970,421...95,012,071
Ensembl chr13:94,970,424...95,011,972

G

MINDY lysine 48 deubiquitinase 2

decreases expression

Miconazole results in decreased expression of MINDY2 mRNA

NCBI chr 8:71,268,274...71,327,698
Ensembl chr 8:71,256,447...71,328,453

G

marker of proliferation Ki-67

decreases expression

Miconazole results in decreased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

malectin

increases expression

Miconazole results in increased expression of MLEC mRNA

NCBI chr12:41,458,234...41,468,710
Ensembl chr12:41,458,231...41,468,708

G

MLLT6, PHD finger containing

decreases expression

Miconazole results in decreased expression of MLLT6 mRNA

NCBI chr10:82,657,258...82,678,899
Ensembl chr10:82,656,872...82,676,073

G

metabolism of cobalamin associated B

increases expression

Miconazole results in increased expression of MMAB mRNA

NCBI chr12:42,159,109...42,172,518
Ensembl chr12:42,159,089...42,172,490

G

modulator of smoothened

decreases expression

Miconazole results in decreased expression of MOSMO mRNA

NCBI chr 1:175,217,680...175,288,521
Ensembl chr 1:175,217,545...175,288,334

G

mannose receptor, C type 2

decreases expression

Miconazole results in decreased expression of MRC2 mRNA

NCBI chr10:90,261,986...90,323,187
Ensembl chr10:90,261,394...90,322,856

G

mitochondrial ribosomal protein S14

decreases expression

Miconazole results in decreased expression of MRPS14 mRNA

NCBI chr13:72,429,168...72,434,915
Ensembl chr13:72,408,558...72,434,915

G

mitochondrial ribosomal protein S16

increases expression

Miconazole results in increased expression of MRPS16 mRNA

NCBI chr15:3,918,621...3,921,024
Ensembl chr15:3,918,615...3,921,656

G

mitochondrial ribosomal protein S27

increases expression

Miconazole results in increased expression of MRPS27 mRNA

NCBI chr 2:30,740,007...30,808,577
Ensembl chr 2:30,740,033...30,808,577

G

methylsterol monooxygenase 1

increases expression

Miconazole results in increased expression of MSMO1 mRNA

PMID:27462272 PMID:29337257

NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016

G

microtubule crosslinking factor 2

increases expression

Miconazole results in increased expression of MTCL2 mRNA

NCBI chr 3:145,669,102...145,741,578
Ensembl chr 3:145,675,443...145,740,871

G

metadherin

decreases expression

Miconazole results in decreased expression of MTDH mRNA

NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

increases expression

Miconazole results in increased expression of MTHFD2 mRNA

NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608

G

myosin, heavy chain 9

increases expression

Miconazole results in increased expression of MYH9 mRNA

NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457

G

myosin light chain 12A

increases expression

Miconazole results in increased expression of MYL12A mRNA

NCBI chr 9:110,891,970...110,899,655
Ensembl chr 9:110,873,959...110,916,580

G

myosin IXA

decreases expression

Miconazole results in decreased expression of MYO9A mRNA

NCBI chr 8:60,149,234...60,352,330
Ensembl chr 8:60,149,234...60,350,514

G

myb-like, SWIRM and MPN domains 1

decreases expression

Miconazole results in decreased expression of MYSM1 mRNA

NCBI chr 5:109,761,345...109,826,652
Ensembl chr 5:109,776,286...109,819,967

G

N(alpha)-acetyltransferase 15, NatA auxiliary subunit

decreases expression

Miconazole results in decreased expression of NAA15 mRNA

NCBI chr 2:135,458,018...135,520,756
Ensembl chr 2:135,457,948...135,520,756

G

nuclear prelamin A recognition factor

increases expression

Miconazole results in increased expression of NARF mRNA

NCBI chr10:106,519,508...106,537,494
Ensembl chr10:106,519,444...106,537,486

G

nuclear autoantigenic sperm protein

decreases expression

Miconazole results in decreased expression of NASP mRNA

NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928

G

non-SMC condensin I complex, subunit D2

increases expression

Miconazole results in increased expression of NCAPD2 mRNA

NCBI chr 4:157,968,814...157,992,314
Ensembl chr 4:157,968,815...157,992,020

G

neutrophil cytosolic factor 1

decreases expression

Miconazole results in decreased expression of NCF1 mRNA

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

NCK-associated protein 5-like

increases expression

Miconazole results in increased expression of NCKAP5L mRNA

NCBI chr 7:130,553,683...130,591,886
Ensembl chr 7:130,555,368...130,591,857

G

nicalin

increases expression

Miconazole results in increased expression of NCLN mRNA

NCBI chr 7:8,211,978...8,221,938
Ensembl chr 7:8,211,996...8,221,934

G

nuclear receptor coactivator 1

multiple interactions

Miconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Miconazole promotes the reaction [Rifampin results in increased expression of NCOA1 mRNA]

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

NADH:ubiquinone oxidoreductase subunit A9

increases expression

Miconazole results in increased expression of NDUFA9 mRNA

NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018

G

NHP2 ribonucleoprotein

increases expression

Miconazole results in increased expression of NHP2 mRNA

NCBI chr10:35,877,057...35,880,399
Ensembl chr10:35,877,054...35,882,545

G

NOP56 ribonucleoprotein

increases expression

Miconazole results in increased expression of NOP56 mRNA

NCBI chr 3:117,476,963...117,481,847
Ensembl chr 3:117,477,053...117,481,841

G

nitric oxide synthase 2

increases expression

Miconazole results in increased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 1

increases expression

Miconazole results in increased expression of NOTCH1 mRNA

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

NOVA alternative splicing regulator 1

decreases expression

Miconazole results in decreased expression of NOVA1 mRNA

NCBI chr 6:63,780,105...63,905,567
Ensembl chr 6:63,783,489...63,906,289

G

NOVA alternative splicing regulator 2

decreases expression

Miconazole results in decreased expression of NOVA2 mRNA

NCBI chr 1:78,572,253...78,613,703
Ensembl chr 1:78,572,279...78,608,021

G

NADPH oxidase 1

decreases expression

Miconazole results in decreased expression of NOX1 mRNA

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

NPC intracellular cholesterol transporter 2

increases expression

Miconazole results in increased expression of NPC2 mRNA

NCBI chr 6:104,397,239...104,418,161
Ensembl chr 6:104,378,644...104,418,155

G

aminopeptidase puromycin sensitive

decreases expression

Miconazole results in decreased expression of NPEPPS mRNA

NCBI chr10:82,191,454...82,273,967
Ensembl chr10:82,191,456...82,273,967

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity
decreases expression
decreases activity

Miconazole binds to and results in increased activity of NR1I2 protein; Miconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; Miconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Miconazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]
Miconazole results in increased activity of NR1I2 protein
Miconazole results in decreased expression of NR1I2 mRNA
Miconazole results in decreased activity of NR1I2 protein

PMID:16608920 PMID:17438109 PMID:17998298 PMID:27732639 PMID:28259787

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

decreases expression
increases activity

Miconazole results in decreased expression of NR1I3 mRNA
Miconazole results in increased activity of NR1I3 protein

PMID:16608920 PMID:27732639

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

Miconazole inhibits the reaction [Dexamethasone binds to and results in increased activity of NR3C1 protein]

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

NAD(P) dependent steroid dehydrogenase-like

increases expression

Miconazole results in increased expression of NSDHL mRNA

NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142

G

nth-like DNA glycosylase 1

increases expression

Miconazole results in increased expression of NTHL1 mRNA

NCBI chr10:13,655,791...13,661,958
Ensembl chr10:13,655,785...13,661,957

G

NUBP iron-sulfur cluster assembly factor 2

increases expression

Miconazole results in increased expression of NUBP2 mRNA

NCBI chr10:13,903,224...13,906,928
Ensembl chr10:13,903,224...13,906,969

G

nuclear distribution C, dynein complex regulator

increases expression

Miconazole results in increased expression of NUDC mRNA

NCBI chr 5:145,758,006...145,771,390
Ensembl chr 5:145,758,002...145,771,425

G

nuclear FMR1 interacting protein 2

decreases expression

Miconazole results in decreased expression of NUFIP2 mRNA

NCBI chr10:62,574,922...62,607,729
Ensembl chr10:62,574,882...62,600,346

G

ornithine decarboxylase 1

increases expression

Miconazole results in increased expression of ODC1 mRNA

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

8-oxoguanine DNA glycosylase

decreases expression

Miconazole results in decreased expression of OGG1 mRNA

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

O-linked N-acetylglucosamine (GlcNAc) transferase

decreases expression

Miconazole results in decreased expression of OGT mRNA

NCBI chr X:66,771,278...66,816,148
Ensembl chr X:66,771,349...66,816,146

G

Opa interacting protein 5

increases expression

Miconazole results in increased expression of OIP5 mRNA

NCBI chr 3:106,593,746...106,603,281
Ensembl chr 3:106,593,760...106,603,250

G

one cut homeobox 2

decreases expression

Miconazole results in decreased expression of ONECUT2 mRNA

NCBI chr18:57,831,647...57,890,884
Ensembl chr18:57,832,111...57,879,629

G

outer mitochondrial membrane lipid metabolism regulator OPA3

increases expression

Miconazole results in increased expression of OPA3 mRNA

NCBI chr 1:78,879,612...78,910,453
Ensembl chr 1:78,880,114...78,901,469
Ensembl chr 1:78,880,114...78,901,469

G

oxidation resistance 1

decreases expression

Miconazole results in decreased expression of OXR1 mRNA

NCBI chr 7:72,528,750...72,965,666
Ensembl chr 7:72,528,786...72,965,666

G

proliferation-associated 2G4

increases expression

Miconazole results in increased expression of PA2G4 mRNA

NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331

G

pantothenate kinase 3

increases expression

Miconazole results in increased expression of PANK3 mRNA

NCBI chr10:20,229,129...20,252,955
Ensembl chr10:20,229,129...20,252,955

G

protocadherin 17

decreases expression

Miconazole results in decreased expression of PCDH17 mRNA

NCBI chr15:60,222,088...60,316,172
Ensembl chr15:60,222,004...60,313,999

G

PCNA clamp associated factor

decreases expression

Miconazole results in decreased expression of PCLAF mRNA

NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994

G

proliferating cell nuclear antigen

increases expression

Miconazole results in increased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

prenylcysteine oxidase 1 like

increases expression

Miconazole results in increased expression of PCYOX1L mRNA

NCBI chr18:55,150,637...55,161,334
Ensembl chr18:55,150,650...55,161,327

G

protein disulfide isomerase family A, member 6

decreases expression

Miconazole results in decreased expression of PDIA6 mRNA

NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613

G

proliferation and apoptosis adaptor protein 15

increases expression

Miconazole results in increased expression of PEA15A mRNA

NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499

G

prefoldin subunit 1

increases expression

Miconazole results in increased expression of PFDN1 mRNA

NCBI chr18:28,014,145...28,067,148
Ensembl chr18:28,014,145...28,067,064

G

phosphoglycerate mutase 1

increases expression

Miconazole results in increased expression of PGAM1 mRNA

NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452

G

post-GPI attachment to proteins inositol deacylase 1

decreases expression

Miconazole results in decreased expression of PGAP1 mRNA

NCBI chr 9:55,975,574...56,044,325
Ensembl chr 9:55,975,667...56,044,464

G

protein geranylgeranyltransferase type I subunit beta

decreases expression

Miconazole results in decreased expression of PGGT1B mRNA

NCBI chr18:38,952,147...38,995,656
Ensembl chr18:38,952,914...38,995,503

G

phosphoglycerate kinase 1

increases expression

Miconazole results in increased expression of PGK1 mRNA

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

phosphoglycolate phosphatase

increases expression

Miconazole results in increased expression of PGP mRNA

NCBI chr10:13,495,232...13,497,858
Ensembl chr10:13,494,291...13,497,858

G

prohibitin 1

increases expression

Miconazole results in increased expression of PHB1 mRNA

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

G

PICALM interacting mitotic regulator

increases expression

Miconazole results in increased expression of PIMREG mRNA

NCBI chr10:56,669,603...56,674,540
Ensembl chr10:56,669,675...56,674,791

G

pyruvate kinase M1/2

increases expression

Miconazole results in increased expression of PKM mRNA

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

protein kinase N2

decreases expression

Miconazole results in decreased expression of PKN2 mRNA

NCBI chr 2:231,793,584...231,898,953
Ensembl chr 2:231,793,584...231,898,953

G

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3

increases expression

Miconazole results in increased expression of PLOD3 mRNA

NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960

G

DNA polymerase delta 1, catalytic subunit

increases expression

Miconazole results in increased expression of POLD1 mRNA

NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465

G

DNA polymerase delta 2, accessory subunit

increases expression

Miconazole results in increased expression of POLD2 mRNA

NCBI chr14:80,748,971...80,755,188
Ensembl chr14:80,748,974...80,755,160

G

DNA polymerase delta 4, accessory subunit

decreases expression

Miconazole results in decreased expression of POLD4 mRNA

NCBI chr 1:201,526,591...201,528,406
Ensembl chr 1:201,526,665...201,528,401

G

RNA polymerase I and III subunit C

increases expression

Miconazole results in increased expression of POLR1C mRNA

NCBI chr 9:14,735,740...14,739,852
Ensembl chr 9:14,735,714...14,739,852

G

RNA polymerase II subunit A

decreases expression

Miconazole results in decreased expression of POLR2A mRNA

NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455

G

paraoxonase 2

decreases expression

Miconazole results in decreased expression of PON2 mRNA

NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248

G

peptidylprolyl isomerase like 1

increases expression

Miconazole results in increased expression of PPIL1 mRNA

NCBI chr20:7,302,292...7,322,349
Ensembl chr20:7,302,621...7,322,354

G

protein phosphatase, Mg2+/Mn2+ dependent, 1G

increases expression

Miconazole results in increased expression of PPM1G mRNA

NCBI chr 6:25,153,556...25,173,763
Ensembl chr 6:25,153,556...25,173,761

G

protein phosphatase 1, regulatory subunit 3C

increases expression

Miconazole results in increased expression of PPP1R3C mRNA

NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961

G

protein phosphatase 2 catalytic subunit beta

decreases expression

Miconazole results in decreased expression of PPP2CB mRNA

NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576

G

protein phosphatase 2 scaffold subunit A alpha

increases expression

Miconazole results in increased expression of PPP2R1A mRNA

NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129

G

protein phosphatase 3, regulatory subunit B, alpha

decreases expression

Miconazole results in decreased expression of PPP3R1 mRNA

NCBI chr14:91,556,743...91,606,391
Ensembl chr14:91,604,121...91,606,907

G

protein phosphatase 4, regulatory subunit 3B

decreases expression

Miconazole results in decreased expression of PPP4R3B mRNA

NCBI chr14:102,917,043...102,965,210
Ensembl chr14:102,917,443...103,068,192

G

peroxiredoxin 3

decreases expression

Miconazole results in decreased expression of PRDX3 mRNA

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

G

parkin RBR E3 ubiquitin protein ligase

increases expression

Miconazole results in increased expression of PRKN mRNA

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

proline and serine rich 1

decreases expression

Miconazole results in decreased expression of PROSER1 mRNA

NCBI chr 2:137,542,378...137,561,767
Ensembl chr 2:137,542,378...137,561,767

G

pre-mRNA processing factor 40 homolog A

decreases expression

Miconazole results in decreased expression of PRPF40A mRNA

NCBI chr 3:37,625,585...37,689,859
Ensembl chr 3:37,627,690...37,690,886

G

pre-mRNA processing factor 8

increases expression

Miconazole results in increased expression of PRPF8 mRNA

NCBI chr10:60,331,494...60,354,606
Ensembl chr10:60,331,494...60,354,606

G

proline rich 12

increases expression

Miconazole results in increased expression of PRR12 mRNA

NCBI chr 1:95,510,015...95,534,002
Ensembl chr 1:95,509,931...95,533,652

G

proline-rich coiled-coil 2C

decreases expression

Miconazole results in decreased expression of PRRC2C mRNA

NCBI chr13:75,003,995...75,073,701
Ensembl chr13:75,004,010...75,073,643

G

serine protease 12

increases expression

Miconazole results in increased expression of PRSS12 mRNA

NCBI chr 2:211,624,134...211,684,126
Ensembl chr 2:211,624,134...211,684,126

G

prune homolog 2 with BCH domain

increases expression

Miconazole results in increased expression of PRUNE2 mRNA

NCBI chr 1:214,352,586...214,624,848
Ensembl chr 1:214,352,955...214,622,650

G

presenilin 1

decreases expression

Miconazole results in decreased expression of PSEN1 mRNA

NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650

G

PC4 and SRSF1 interacting protein 1

decreases expression

Miconazole results in decreased expression of PSIP1 mRNA

NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257

G

proteasome 20S subunit alpha 5

increases expression

Miconazole results in increased expression of PSMA5 mRNA

NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731

G

proteasome 20S subunit beta 4

increases expression

Miconazole results in increased expression of PSMB4 mRNA

NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746

G

proteasome 26S subunit, ATPase 6

decreases expression

Miconazole results in decreased expression of PSMC6 mRNA

NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055

G

proteasome 26S subunit, non-ATPase 7

increases expression

Miconazole results in increased expression of PSMD7 mRNA

NCBI chr19:35,494,317...35,501,605
Ensembl chr19:35,494,316...35,501,588

G

proteasome activator subunit 4

decreases expression

Miconazole results in decreased expression of PSME4 mRNA

NCBI chr14:104,505,716...104,609,410
Ensembl chr14:104,505,716...104,609,408

G

prostaglandin-endoperoxide synthase 1

decreases expression

Miconazole results in decreased expression of PTGS1 mRNA

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

pleiotrophin

increases expression

Miconazole results in increased expression of PTN mRNA

NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456

G

protein tyrosine phosphatase, receptor type, N

decreases expression

Miconazole results in decreased expression of PTPRN mRNA

NCBI chr 9:76,741,010...76,756,704
Ensembl chr 9:76,741,016...76,756,190

G

protein tyrosine phosphatase, receptor type, S

increases expression

Miconazole results in increased expression of PTPRS mRNA

NCBI chr 9:1,245,408...1,307,015
Ensembl chr 9:1,245,410...1,306,947

G

protein tyrosine phosphatase, receptor type Z1

decreases expression

Miconazole results in decreased expression of PTPRZ1 mRNA

NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218

G

purine rich element binding protein B

decreases expression

Miconazole results in decreased expression of PURB mRNA

NCBI chr14:81,342,374...81,344,857
Ensembl chr14:81,336,448...81,351,432

G

quinoid dihydropteridine reductase

increases expression

Miconazole results in increased expression of QDPR mRNA

NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854

G

QKI, KH domain containing RNA binding

decreases expression

Miconazole results in decreased expression of QKI mRNA

NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831

G

glutamine and serine rich 1

decreases expression

Miconazole results in decreased expression of QSER1 mRNA

NCBI chr 3:91,137,516...91,202,426
Ensembl chr 3:91,140,967...91,202,052

G

R3H domain containing 1

decreases expression

Miconazole results in decreased expression of R3HDM1 mRNA

NCBI chr13:39,595,848...39,733,876
Ensembl chr13:39,595,848...39,733,876

G

RAB GTPase activating protein 1-like

decreases expression

Miconazole results in decreased expression of RABGAP1L mRNA

NCBI chr13:72,464,114...73,059,845
Ensembl chr13:72,468,110...73,059,984

G

RAN binding protein 2

decreases expression

Miconazole results in decreased expression of RANBP2 mRNA

NCBI chr20:26,442,156...26,493,481
Ensembl chr20:26,442,217...26,493,481

G

RAS p21 protein activator 1

decreases expression

Miconazole results in decreased expression of RASA1 mRNA

NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854

G

RB transcriptional corepressor 1

decreases expression

Miconazole results in decreased expression of RB1 mRNA

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RB binding protein 4, chromatin remodeling factor

increases expression

Miconazole results in increased expression of RBBP4 mRNA

NCBI chr 5:141,655,863...141,675,157
Ensembl chr 5:141,638,421...141,675,284

G

RB binding protein 6, ubiquitin ligase

decreases expression

Miconazole results in decreased expression of RBBP6 mRNA

NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678

G

ring finger and CCCH-type domains 1

decreases expression

Miconazole results in decreased expression of RC3H1 mRNA

NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839

G

regulator of chromosome condensation 2

increases expression

Miconazole results in increased expression of RCC2 mRNA

NCBI chr 5:152,994,406...153,017,223
Ensembl chr 5:152,993,665...153,017,205

G

arginine-glutamic acid dipeptide repeats

decreases expression

Miconazole results in decreased expression of RERE mRNA

NCBI chr 5:160,765,855...161,097,678
Ensembl chr 5:160,765,934...161,097,677

G

REV3 like, DNA directed polymerase zeta catalytic subunit

decreases expression

Miconazole results in decreased expression of REV3L mRNA

NCBI chr20:43,131,841...43,290,102
Ensembl chr20:43,132,363...43,290,099

G

regulatory factor X, 7

decreases expression

Miconazole results in decreased expression of RFX7 mRNA

NCBI chr 8:73,254,051...73,339,209
Ensembl chr 8:73,254,051...73,339,209

G

ring finger protein 40

increases expression

Miconazole results in increased expression of RNF40 mRNA

NCBI chr 1:182,202,475...182,217,899
Ensembl chr 1:182,202,600...182,217,241

G

ring finger protein 7

increases expression

Miconazole results in increased expression of RNF7 mRNA

NCBI chr 8:97,038,845...97,048,080
Ensembl chr 8:97,038,840...97,047,824

G

Ro60, Y RNA binding protein

decreases expression

Miconazole results in decreased expression of RO60 mRNA

NCBI chr13:55,499,514...55,520,504
Ensembl chr13:55,499,534...55,520,504

G

Rho-associated coiled-coil containing protein kinase 1

decreases expression

Miconazole results in decreased expression of ROCK1 mRNA

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

Rho-associated coiled-coil containing protein kinase 2

decreases expression

Miconazole results in decreased expression of ROCK2 mRNA

NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031

G

ribosomal protein L11

increases expression

Miconazole results in increased expression of RPL11 mRNA

NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599

G

ribosomal protein L14

increases expression

Miconazole results in increased expression of RPL14 mRNA

NCBI chr 8:120,286,035...120,289,160
Ensembl chr 8:120,284,645...120,289,064

G

ribosomal protein L15

increases expression

Miconazole results in increased expression of RPL15 mRNA

NCBI chr15:7,503,883...7,507,166
Ensembl chr15:7,503,883...7,507,165

G

ribosomal protein L17

increases expression

Miconazole results in increased expression of RPL17 mRNA

NCBI chr18:68,581,141...68,584,253
Ensembl chr18:68,581,098...68,584,253

G

ribosomal protein L24

increases expression

Miconazole results in increased expression of RPL24 mRNA

NCBI chr11:44,653,937...44,659,346
Ensembl chr11:44,653,937...44,659,370

G

ribosomal protein L27A

increases expression

Miconazole results in increased expression of RPL27A mRNA

NCBI chr 1:163,539,732...163,542,771

G

ribosomal protein L28

increases expression

Miconazole results in increased expression of RPL28 mRNA

NCBI chr 1:69,052,148...69,054,735
Ensembl chr 1:69,053,203...69,055,032

G

ribosomal protein L37

increases expression

Miconazole results in increased expression of RPL37 mRNA

NCBI chr 2:54,215,469...54,217,429
Ensembl chr 2:54,215,469...54,217,442

G

ribosomal protein L37A

increases expression

Miconazole results in increased expression of RPL37A mRNA

NCBI chr 9:74,298,843...74,300,926

G

ribosomal protein L5

affects expression

Miconazole affects the expression of RPL5 mRNA

NCBI chr14:1,843,856...1,850,301
Ensembl chr14:1,843,770...1,850,290

G

ribosomal protein L6

increases expression

Miconazole results in increased expression of RPL6 mRNA

NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921

G

ribosomal protein L7

increases expression

Miconazole results in increased expression of RPL7 mRNA

NCBI chr 5:3,217,184...3,220,192

G

ribosomal protein lateral stalk subunit P0

increases expression

Miconazole results in increased expression of RPLP0 mRNA

NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632

G

ribophorin I

increases expression

Miconazole results in increased expression of RPN1 mRNA

NCBI chr 4:120,543,667...120,565,069
Ensembl chr 4:120,543,667...120,565,069

G

ribosomal protein S14

increases expression

Miconazole results in increased expression of RPS14 mRNA

NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166

G

ribosomal protein S18

increases expression

Miconazole results in increased expression of RPS18 mRNA

NCBI chr20:4,931,427...4,935,538
Ensembl chr10:101,204,500...101,205,146
Ensembl chr20:101,204,500...101,205,146

G

ribosomal protein S20

increases expression

Miconazole results in increased expression of RPS20 mRNA

NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475

G

ribosomal protein S26

increases expression

Miconazole results in increased expression of RPS26 mRNA

NCBI chr 7:1,057,332...1,058,882

G

ribosomal protein S6

increases expression

Miconazole results in increased expression of RPS6 mRNA

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase B1

decreases expression

Miconazole results in decreased expression of RPS6KB1 mRNA

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

ribosomal protein S7

increases expression

Miconazole results in increased expression of RPS7 mRNA

NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145

G

ribosomal protein S8

increases expression

Miconazole results in increased expression of RPS8 mRNA

NCBI chr 5:130,630,362...130,632,932
Ensembl chr 5:130,629,716...130,633,268

G

ribonucleotide reductase regulatory subunit M2

increases expression

Miconazole results in increased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

remodeling and spacing factor 1

decreases expression

Miconazole results in decreased expression of RSF1 mRNA

NCBI chr 1:151,892,055...152,015,089
Ensembl chr 1:151,892,434...152,009,051

G

ribosomal L24 domain containing 1

increases expression

Miconazole results in increased expression of RSL24D1 mRNA

NCBI chr 8:73,852,991...73,861,996
Ensembl chr 8:73,852,996...73,862,001

G

Sin3A associated protein 18

increases expression

Miconazole results in increased expression of SAP18 mRNA

NCBI chr15:31,943,228...31,947,534
Ensembl chr15:31,943,230...31,950,038
Ensembl chr10:31,943,230...31,950,038

G

stearoyl-CoA desaturase

increases expression

Miconazole results in increased expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

secernin 1

increases expression

Miconazole results in increased expression of SCRN1 mRNA

NCBI chr 4:83,632,125...83,694,225
Ensembl chr 4:83,632,131...83,693,852

G

syndecan 1

decreases expression

Miconazole results in decreased expression of SDC1 mRNA

NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264

G

stromal cell derived factor 2

increases expression

Miconazole results in increased expression of SDF2 mRNA

NCBI chr10:63,140,563...63,151,038
Ensembl chr10:63,140,563...63,201,109

G

succinate dehydrogenase complex flavoprotein subunit A

increases expression

Miconazole results in increased expression of SDHA mRNA

NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535

G

SEC13 homolog, nuclear pore and COPII coat complex component

increases expression

Miconazole results in increased expression of SEC13 mRNA

NCBI chr 4:146,877,739...146,891,130
Ensembl chr 4:146,875,524...146,891,173

G

SEC62 homolog, preprotein translocation factor

decreases expression

Miconazole results in decreased expression of SEC62 mRNA

NCBI chr 2:112,570,810...112,598,198
Ensembl chr 2:112,570,819...112,601,814

G

selenoprotein K

increases expression

Miconazole results in increased expression of SELENOK mRNA

NCBI chr16:5,152,066...5,160,648
Ensembl chr16:5,152,066...5,159,188

G

selenoprotein T

decreases expression

Miconazole results in decreased expression of SELENOT mRNA

NCBI chr 2:142,804,387...142,821,438
Ensembl chr 2:142,804,405...142,821,427

G

semaphorin 3D

decreases expression

Miconazole results in decreased expression of SEMA3D mRNA

NCBI chr 4:22,316,769...22,505,930
Ensembl chr 4:22,316,779...22,505,930

G

serpin family E member 2

increases expression

Miconazole results in increased expression of SERPINE2 mRNA

NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826

G

SET domain containing 2, histone lysine methyltransferase

decreases expression

Miconazole results in decreased expression of SETD2 mRNA

NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489

G

senataxin

decreases expression

Miconazole results in decreased expression of SETX mRNA

NCBI chr 3:12,428,091...12,480,801
Ensembl chr 3:12,427,635...12,480,803

G

splicing factor 3b, subunit 1

decreases expression

Miconazole results in decreased expression of SF3B1 mRNA

NCBI chr 9:56,492,403...56,532,300
Ensembl chr 9:56,492,403...56,532,300

G

splicing factor proline and glutamine rich

decreases expression

Miconazole results in decreased expression of SFPQ mRNA

NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472

G

SWI5-dependent homologous recombination repair protein 1

increases expression

Miconazole results in increased expression of SFR1 mRNA

NCBI chr 1:246,619,235...246,623,250
Ensembl chr 1:246,597,044...246,623,250

G

sideroflexin 2

decreases expression

Miconazole results in decreased expression of SFXN2 mRNA

NCBI chr 1:245,447,014...245,459,312
Ensembl chr 1:245,447,015...245,468,411
Ensembl chr 1:245,447,015...245,468,411

G

SH3 domain binding glutamate rich protein like 1

decreases expression

Miconazole results in decreased expression of SH3BGRL mRNA

NCBI chr X:74,167,029...74,263,783
Ensembl chr X:74,166,871...74,263,783

G

Ski proto-oncogene

decreases expression

Miconazole results in decreased expression of SKI mRNA

NCBI chr 5:165,713,525...165,782,134
Ensembl chr 5:165,714,093...165,782,733

G

solute carrier family 12, member 6

decreases expression

Miconazole results in decreased expression of SLC12A6 mRNA

NCBI chr 3:99,071,577...99,170,266
Ensembl chr 3:99,071,391...99,170,258

G

solute carrier family 22 member 2

multiple interactions

Miconazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 25 member 3

decreases expression

Miconazole results in decreased expression of SLC25A3 mRNA

NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727

G

solute carrier family 25 member 5

increases expression

Miconazole results in increased expression of SLC25A5 mRNA

NCBI chr X:116,031,896...116,034,963
Ensembl chr X:116,031,803...116,034,967

G

solute carrier family 35, member F1

decreases expression

Miconazole results in decreased expression of SLC35F1 mRNA

NCBI chr20:32,030,350...32,418,762
Ensembl chr20:32,030,368...32,418,611

G

solute carrier family 46 member 1

increases expression

Miconazole results in increased expression of SLC46A1 mRNA

NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848

G

solute carrier family 6 member 1

decreases expression

Miconazole results in decreased expression of SLC6A1 mRNA

NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

decreases expression

Miconazole results in decreased expression of SMARCA5 mRNA

NCBI chr19:27,271,918...27,304,594
Ensembl chr19:27,271,148...27,304,594

G

structural maintenance of chromosomes 3

decreases expression

Miconazole results in decreased expression of SMC3 mRNA

NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522

G

structural maintenance of chromosomes flexible hinge domain containing 1

decreases expression

Miconazole results in decreased expression of SMCHD1 mRNA

NCBI chr 9:111,243,445...111,387,272
Ensembl chr 9:111,247,702...111,349,665

G

small integral membrane protein 10 like 1

decreases expression

Miconazole results in decreased expression of SMIM10L1 mRNA

NCBI chr 4:166,341,699...166,345,530
Ensembl chr 4:166,342,328...166,343,410
Ensembl chr 4:166,342,328...166,343,410

G

small nuclear ribonucleoprotein 13

increases expression

Miconazole results in increased expression of SNU13 mRNA

NCBI chr 7:113,565,293...113,570,887
Ensembl chr 7:113,565,295...113,570,872
Ensembl chr 1:113,565,295...113,570,872

G

SON DNA and RNA binding protein

decreases expression

Miconazole results in decreased expression of SON mRNA

NCBI chr11:30,850,890...30,923,167
Ensembl chr11:30,892,005...30,923,167

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

Miconazole results in decreased expression of SOS1 mRNA

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

SRY-box transcription factor 2

increases expression

Miconazole results in increased expression of SOX2 mRNA

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

SPARC like 1

increases expression

Miconazole results in increased expression of SPARCL1 mRNA

NCBI chr14:5,632,816...5,663,866
Ensembl chr14:5,632,569...5,663,865

G

sperm antigen with calponin homology and coiled-coil domains 1

decreases expression

Miconazole results in decreased expression of SPECC1 mRNA

NCBI chr10:46,638,947...46,912,989
Ensembl chr10:46,638,809...46,912,802

G

serine palmitoyltransferase, small subunit A

decreases expression

Miconazole results in decreased expression of SPTSSA mRNA

NCBI chr 6:72,144,714...72,156,130
Ensembl chr 6:72,144,714...72,156,214

G

sequestosome 1

multiple interactions
increases expression

bafilomycin A1 promotes the reaction [Miconazole results in increased expression of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

Snf2-related CREBBP activator protein

increases expression

Miconazole results in increased expression of SRCAP mRNA

NCBI chr 1:182,123,562...182,172,643
Ensembl chr 1:182,118,416...182,176,610

G

splicing regulatory glutamic acid and lysine rich protein 1

decreases expression

Miconazole results in decreased expression of SREK1 mRNA

NCBI chr 2:34,849,548...34,885,120
Ensembl chr 2:34,852,458...34,884,972

G

SRSF protein kinase 2

decreases expression

Miconazole results in decreased expression of SRPK2 mRNA

NCBI chr 4:11,464,684...11,655,993
Ensembl chr 4:11,464,674...11,655,990

G

serine and arginine rich splicing factor 11

decreases expression

Miconazole results in decreased expression of SRSF11 mRNA

NCBI chr 2:247,074,623...247,101,460
Ensembl chr 2:247,074,631...247,101,425

G

single stranded DNA binding protein 4

decreases expression

Miconazole results in decreased expression of SSBP4 mRNA

NCBI chr16:18,828,014...18,838,941
Ensembl chr16:18,828,054...18,838,947

G

StAR-related lipid transfer domain containing 4

increases expression

Miconazole results in increased expression of STARD4 mRNA

NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024

G

stanniocalcin 2

increases expression

Miconazole results in increased expression of STC2 mRNA

NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973

G

SUN domain containing ossification factor

decreases expression

Miconazole results in decreased expression of SUCO mRNA

NCBI chr13:74,192,808...74,257,896
Ensembl chr13:74,193,573...74,257,896

G

TAO kinase 1

decreases expression

Miconazole results in decreased expression of TAOK1 mRNA

NCBI chr10:62,373,072...62,465,295
Ensembl chr10:62,381,404...62,465,766

G

tyrosine aminotransferase

increases expression
decreases expression

Miconazole results in increased expression of TAT mRNA
Miconazole results in decreased expression of TAT mRNA

PMID:16608920 PMID:22262564

NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031

G

Tax1 binding protein 1

decreases expression

Miconazole results in decreased expression of TAX1BP1 mRNA

NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100

G

transcription factor 12

decreases expression

Miconazole results in decreased expression of TCF12 mRNA

NCBI chr 8:72,490,447...72,799,265
Ensembl chr 8:72,492,567...72,799,201

G

thymine-DNA glycosylase

decreases expression

Miconazole results in decreased expression of TDG mRNA

NCBI chr 7:21,077,853...21,097,617
Ensembl chr 7:21,077,853...21,097,567

G

THO complex subunit 2

decreases expression

Miconazole results in decreased expression of THOC2 mRNA

NCBI chr X:120,634,966...120,749,569
Ensembl chr X:120,634,968...120,749,513

G

TIA1 cytotoxic granule-associated RNA binding protein

decreases expression

Miconazole results in decreased expression of TIA1 mRNA

NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586

G

talin 1

increases expression

Miconazole results in increased expression of TLN1 mRNA

NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900

G

transmembrane p24 trafficking protein 5

decreases expression

Miconazole results in decreased expression of TMED5 mRNA

NCBI chr14:1,607,895...1,619,028
Ensembl chr14:1,607,819...1,628,426

G

transmembrane protein 106B

decreases expression

Miconazole results in decreased expression of TMEM106B mRNA

NCBI chr 4:41,328,125...41,347,315
Ensembl chr 4:41,327,994...41,345,619

G

transmembrane protein 167A

decreases expression

Miconazole results in decreased expression of TMEM167 mRNA

NCBI chr 2:21,197,799...21,216,746
Ensembl chr 2:21,197,786...21,212,099

G

transmembrane protein 30A

decreases expression

Miconazole results in decreased expression of TMEM30A mRNA

NCBI chr 8:80,728,749...80,757,197
Ensembl chr 8:80,729,619...80,753,248

G

transmembrane protein 47

decreases expression

Miconazole results in decreased expression of TMEM47 mRNA

NCBI chr X:45,421,405...45,447,900
Ensembl chr X:45,421,405...45,447,900

G

transmembrane protein 97

increases expression

Miconazole results in increased expression of TMEM97 mRNA

NCBI chr10:63,438,228...63,447,311
Ensembl chr10:63,438,222...63,589,730

G

TATA element modulatory factor 1

decreases expression

Miconazole results in decreased expression of TMF1 mRNA

NCBI chr 4:129,759,952...129,785,705
Ensembl chr 4:129,763,114...129,785,629

G

thioredoxin-related transmembrane protein 3

decreases expression

Miconazole results in decreased expression of TMX3 mRNA

NCBI chr18:83,731,777...83,764,719
Ensembl chr18:83,731,868...83,762,263

G

trinucleotide repeat containing 18

decreases expression

Miconazole results in decreased expression of TNRC18 mRNA

NCBI chr12:11,755,394...11,851,717
Ensembl chr12:11,755,392...11,851,384

G

DNA topoisomerase I

decreases expression

Miconazole results in decreased expression of TOP1 mRNA

NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623

G

DNA topoisomerase II beta

decreases expression

Miconazole results in decreased expression of TOP2B mRNA

NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085

G

translocated promoter region, nuclear basket protein

decreases expression

Miconazole results in decreased expression of TPR mRNA

NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496

G

tumor protein, translationally-controlled 1

affects expression

Miconazole affects the expression of TPT1 mRNA

NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625

G

tripartite motif-containing 28

increases expression

Miconazole results in increased expression of TRIM28 mRNA

NCBI chr 1:73,652,441...73,659,388
Ensembl chr 1:73,652,709...73,659,380

G

tripartite motif-containing 35

increases expression

Miconazole results in increased expression of TRIM35 mRNA

NCBI chr15:40,493,697...40,510,246
Ensembl chr15:40,493,755...40,510,240

G

tripartite motif-containing 62

increases expression

Miconazole results in increased expression of TRIM62 mRNA

NCBI chr 5:141,230,830...141,260,629
Ensembl chr 5:141,231,523...141,259,915

G

transient receptor potential cation channel, subfamily M, member 2

multiple interactions

Miconazole inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]

NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181

G

tubulin, alpha 1A

increases expression

Miconazole results in increased expression of TUBA1A mRNA

NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186

G

tubulin, alpha 1B

increases expression

Miconazole results in increased expression of TUBA1B mRNA

NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186

G

tubulin, alpha 1C

increases expression

Miconazole results in increased expression of TUBA1C mRNA

NCBI chr 7:130,192,050...130,199,655
Ensembl chr 7:130,192,016...130,199,647
Ensembl chr X:130,192,016...130,199,647

G

tubulin, beta 5 class I

increases expression

Miconazole results in increased expression of TUBB5 mRNA

NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940

G

thioredoxin-like 1

decreases expression

Miconazole results in decreased expression of TXNL1 mRNA

NCBI chr18:57,125,362...57,155,167
Ensembl chr18:57,125,369...57,165,266

G

thioredoxin reductase 1

decreases expression

Miconazole results in decreased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

ubiquitin-associated protein 2

increases expression

Miconazole results in increased expression of UBAP2 mRNA

NCBI chr 5:56,348,243...56,437,403
Ensembl chr 5:56,348,246...56,437,049

G

ubiquitin protein ligase E3 component n-recognin 4

affects expression

Miconazole affects the expression of UBR4 mRNA

NCBI chr 5:151,635,825...151,743,931
Ensembl chr 5:151,635,868...151,743,784

G

uridine-cytidine kinase 2

increases expression

Miconazole results in increased expression of UCK2 mRNA

NCBI chr13:79,380,807...79,438,121
Ensembl chr13:79,383,846...79,438,352

G

ubiquitin specific peptidase 34

decreases expression

Miconazole results in decreased expression of USP34 mRNA

NCBI chr14:97,285,799...97,476,376
Ensembl chr14:97,286,018...97,476,376

G

ubiquitin specific peptidase 9, X-linked

decreases expression

Miconazole results in decreased expression of USP9X mRNA

NCBI chr X:9,588,825...9,726,993
Ensembl chr X:9,588,825...9,696,711

G

vasohibin 1

increases expression

Miconazole results in increased expression of VASH1 mRNA

NCBI chr 6:106,330,374...106,345,740
Ensembl chr 6:106,329,123...106,345,726

G

valosin containing protein interacting protein 1

decreases expression

Miconazole results in decreased expression of VCPIP1 mRNA

NCBI chr 5:9,534,247...9,560,889
Ensembl chr 5:9,534,129...9,562,040

G

VPS37A subunit of ESCRT-I

decreases expression

Miconazole results in decreased expression of VPS37A mRNA

NCBI chr16:51,736,170...51,775,384
Ensembl chr16:51,737,481...51,775,390

G

WD repeat domain 6

increases expression

Miconazole results in increased expression of WDR6 mRNA

NCBI chr 8:109,268,079...109,274,504
Ensembl chr 8:109,268,079...109,274,499

G

WSC domain containing 1

decreases expression

Miconazole results in decreased expression of WSCD1 mRNA

NCBI chr10:56,385,858...56,426,442
Ensembl chr10:56,395,874...56,424,677

G

WT1 associated protein

decreases expression

Miconazole results in decreased expression of WTAP mRNA

NCBI chr 1:47,665,965...47,691,067
Ensembl chr 1:47,665,965...47,691,065

G

exportin 1

decreases expression

Miconazole results in decreased expression of XPO1 mRNA

NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498

G

Y box binding protein 1

increases expression

Miconazole results in increased expression of YBX1 mRNA

NCBI chr 5:132,882,137...132,898,885
Ensembl chr 5:132,882,145...132,898,862

G

YLP motif containing 1

decreases expression

Miconazole results in decreased expression of YLPM1 mRNA

NCBI chr 6:104,642,615...104,718,508
Ensembl chr 6:104,642,615...104,718,508

G

YME1-like 1 ATPase

decreases expression

Miconazole results in decreased expression of YME1L1 mRNA

NCBI chr17:85,287,607...85,326,068
Ensembl chr17:85,287,554...85,326,335

G

zinc finger, C3H1-type containing

decreases expression

Miconazole results in decreased expression of ZFC3H1 mRNA

NCBI chr 7:51,008,251...51,064,666
Ensembl chr 7:51,007,984...51,064,661

G

zinc finger protein 207

decreases expression

Miconazole results in decreased expression of ZFP207 mRNA

NCBI chr10:65,385,807...65,398,086
Ensembl chr10:65,385,740...65,397,386

G

zinc finger protein 24

decreases expression

Miconazole results in decreased expression of ZFP24 mRNA

NCBI chr18:15,295,687...15,307,319
Ensembl chr18:15,298,290...15,306,799

G

zinc finger protein 260

decreases expression

Miconazole results in decreased expression of ZFP260 mRNA

NCBI chr 1:85,336,567...85,349,896
Ensembl chr 1:85,336,618...85,350,067

G

zinc finger protein 326

decreases expression

Miconazole results in decreased expression of ZFP326 mRNA

NCBI chr14:3,941,210...3,980,419
Ensembl chr14:3,941,958...3,980,384

G

zinc finger protein 329

decreases expression

Miconazole results in decreased expression of ZFP329 mRNA

NCBI chr 1:73,403,067...73,498,349
Ensembl chr 1:73,402,972...73,422,037

G

zinc finger protein 354C

decreases expression

Miconazole results in decreased expression of ZFP354C mRNA

NCBI chr10:35,129,720...35,145,717
Ensembl chr10:35,132,959...35,145,661

G

zinc finger protein 395

decreases expression

Miconazole results in decreased expression of ZFP395 mRNA

NCBI chr15:39,581,603...39,621,911
Ensembl chr15:39,608,080...39,619,950

G

zinc finger protein 397

decreases expression

Miconazole results in decreased expression of ZFP397 mRNA

NCBI chr18:15,241,764...15,253,148
Ensembl chr18:15,242,096...15,300,984

G

zinc finger protein 445

decreases expression

Miconazole results in decreased expression of ZFP445 mRNA

NCBI chr 8:122,453,175...122,473,355
Ensembl chr 8:122,454,328...122,473,286

G

zinc finger protein 638

decreases expression

Miconazole results in decreased expression of ZFP638 mRNA

NCBI chr 4:116,355,934...116,475,051
Ensembl chr 4:116,402,428...116,479,845

G

zinc finger protein 654

decreases expression

Miconazole results in decreased expression of ZFP654 mRNA

NCBI chr11:2,500,892...2,565,552
Ensembl chr11:2,503,508...2,565,637

G

zinc finger protein 711

decreases expression

Miconazole results in decreased expression of ZFP711 mRNA

NCBI chr X:77,646,300...77,679,398
Ensembl chr X:77,646,558...77,678,045

G

zinc finger FYVE-type containing 16

decreases expression

Miconazole results in decreased expression of ZFYVE16 mRNA

NCBI chr 2:23,713,018...23,757,576
Ensembl chr 2:23,713,766...23,756,990

G

ZW10 interacting kinetochore protein

decreases expression

Miconazole results in decreased expression of ZWINT mRNA

NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957

neticonazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

neticonazole affects the localization of and results in increased activity of NR1I3 protein

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

oxiconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

oxiconazole results in decreased activity of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases expression

oxiconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]]; oxiconazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]
oxiconazole results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

glutathione S-transferase pi 1

multiple interactions

oxiconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

potassium voltage-gated channel subfamily H member 2

decreases activity

oxiconazole results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

nuclear receptor coactivator 1

multiple interactions

oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; oxiconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Rifampin inhibits the reaction [oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]]

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
decreases expression
decreases activity

oxiconazole binds to and results in increased activity of NR1I2 protein; oxiconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]]; oxiconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]; oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]; oxiconazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]; oxiconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Rifampin inhibits the reaction [oxiconazole promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Rifampin inhibits the reaction [oxiconazole results in increased expression of NR1I2 mRNA]
oxiconazole results in decreased expression of NR1I2 mRNA
oxiconazole results in decreased activity of NR1I2 protein

PMID:17438109 PMID:17998298

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

solute carrier family 22 member 2

multiple interactions

oxiconazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

sertaconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

sertaconazole results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

sulconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression

sulconazole results in increased expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
multiple interactions

sulconazole results in increased expression of CYP2B6 mRNA
[sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
multiple interactions

sulconazole results in increased expression of CYP3A4 mRNA
[sulconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

fatty acid synthase

decreases expression

sulconazole results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

sulconazole results in decreased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glutathione S-transferase pi 1

multiple interactions

sulconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

mediator complex subunit 1

multiple interactions

sulconazole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]

NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

[sulconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

affects localization
multiple interactions
affects binding

sulconazole affects the localization of NR1I3 protein mutant form
[sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; sulconazole binds to and results in increased activity of NR1I3 protein alternative form; sulconazole inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; sulconazole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]
sulconazole binds to NR1I3 protein

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

phosphoenolpyruvate carboxykinase 1

affects expression

sulconazole affects the expression of PCK1 mRNA

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

stearoyl-CoA desaturase

decreases expression

sulconazole results in decreased expression of SCD mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

solute carrier family 22 member 2

multiple interactions

sulconazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

thyroid hormone responsive

affects expression

sulconazole affects the expression of THRSP mRNA

NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19915
role	19885
application	19727
pharmaceutical	19541
drug	19560
antifungal drug	5953
imidazole antifungal drug	1584
Croconazole	0
Lanoconazole	0
Omoconazole nitrate	0
Sulconazole nitrate	0
arasertaconazole +	1
arasertaconazole nitrate +	0
bifonazole	3
butoconazole +	2
butoconazole nitrate +	0
climbazole	3
clotrimazole	324
eberconazole	0
eberconazole nitrate	0
econazole +	13
econazole nitrate	0
enilconazole	110
fenticonazole	0
fenticonazole nitrate	0
flutrimazole	0
isoconazole	1
isoconazole nitrate	0
ketoconazole	843
miconazole +	489
miconazole nitrate	0
neticonazole	1
neticonazole hydrochloride	0
oxiconazole	7
oxiconazole nitrate	0
sertaconazole	1
sertaconazole nitrate	0
sulconazole	13
tioconazole	0
Path 2
Term	Annotations
CHEBI ontology	19915
subatomic particle	19913
composite particle	19895
hadron	19895
baryon	19913
nucleon	19895
atomic nucleus	19913
atom	19895
main group element atom	19852
p-block element atom	19834
carbon group element atom	19774
carbon atom	19770
organic molecular entity	19770
organic molecule	19722
organic cyclic compound	19529
organic heterocyclic compound	18893
heteroarene	17150
monocyclic heteroarene	14999
azole	14501
diazole	10770
imidazoles	10232
imidazole antifungal agent	2002
imidazole antifungal drug	1584
Croconazole	0
Lanoconazole	0
Omoconazole nitrate	0
Sulconazole nitrate	0
arasertaconazole +	1
arasertaconazole nitrate +	0
bifonazole	3
butoconazole +	2
butoconazole nitrate +	0
climbazole	3
clotrimazole	324
eberconazole	0
eberconazole nitrate	0
econazole +	13
econazole nitrate	0
enilconazole	110
fenticonazole	0
fenticonazole nitrate	0
flutrimazole	0
isoconazole	1
isoconazole nitrate	0
ketoconazole	843
miconazole +	489
miconazole nitrate	0
neticonazole	1
neticonazole hydrochloride	0
oxiconazole	7
oxiconazole nitrate	0
sertaconazole	1
sertaconazole nitrate	0
sulconazole	13
tioconazole	0

paths to the root