Dbt (dihydrolipoamide branched chain transacylase E2) - Rat Genome Database

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Gene: Dbt (dihydrolipoamide branched chain transacylase E2) Rattus norvegicus
Analyze
Symbol: Dbt
Name: dihydrolipoamide branched chain transacylase E2
RGD ID: 68403
Description: Predicted to enable acetyltransferase activity; lipoic acid binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in branched-chain amino acid catabolic process. Predicted to be located in cytosol; microtubule cytoskeleton; and mitochondrial nucleoid. Predicted to be part of mitochondrial alpha-ketoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DBT (dihydrolipoamide branched chain transacylase E2); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82207,166,660 - 207,195,528 (+)NCBIGRCr8
mRatBN7.22204,481,744 - 204,510,612 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2204,481,737 - 204,510,609 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2212,138,239 - 212,167,245 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02210,047,347 - 210,076,203 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02204,864,426 - 204,893,276 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02219,563,783 - 219,592,651 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2219,563,783 - 219,592,650 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02237,625,211 - 237,654,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42212,759,312 - 212,788,180 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12212,731,165 - 212,742,429 (+)NCBI
Celera2196,974,438 - 197,002,611 (+)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (ISO)
chromium trinitrate  (ISO)
clofibrate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydroquinone  (ISO)
isobutanol  (ISO)
isotretinoin  (ISO)
mercury dichloride  (ISO)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
miconazole  (ISO)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
oxycodone  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
streptozocin  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Structure of the gene encoding dihydrolipoyl transacylase (E2) component of human branched chain alpha-keto acid dehydrogenase complex and characterization of an E2 pseudogene. Lau KS, etal., J Biol Chem 1992 Nov 25;267(33):24090-6.
4. Rare etiology of autosomal recessive disease in a child with noncarrier parents. Lebo RV, etal., Am J Hum Genet 2000 Sep;67(3):750-4. Epub 2000 Jul 27.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. cDNA cloning of the chicken branched-chain alpha-keto acid dehydrogenase complex. Chicken-specific residues of the acyltransferase affect the overall activity and the interaction with the dehydrogenase. Ono K, etal., Eur J Biochem 2001 Feb;268(3):727-36.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:14651853   PMID:18063578   PMID:18614015   PMID:19725078   PMID:24625528  


Genomics

Comparative Map Data
Dbt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82207,166,660 - 207,195,528 (+)NCBIGRCr8
mRatBN7.22204,481,744 - 204,510,612 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2204,481,737 - 204,510,609 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2212,138,239 - 212,167,245 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02210,047,347 - 210,076,203 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02204,864,426 - 204,893,276 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02219,563,783 - 219,592,651 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2219,563,783 - 219,592,650 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02237,625,211 - 237,654,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42212,759,312 - 212,788,180 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12212,731,165 - 212,742,429 (+)NCBI
Celera2196,974,438 - 197,002,611 (+)NCBICelera
Cytogenetic Map2q42NCBI
DBT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381100,186,919 - 100,249,834 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1100,186,919 - 100,249,834 (-)EnsemblGRCh38hg38GRCh38
GRCh371100,652,475 - 100,715,390 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361100,425,066 - 100,487,997 (-)NCBINCBI36Build 36hg18NCBI36
Build 341100,371,756 - 100,427,411NCBI
Celera198,909,336 - 98,972,208 (-)NCBICelera
Cytogenetic Map1p21.2NCBI
HuRef198,775,207 - 98,838,837 (-)NCBIHuRef
CHM1_11100,768,800 - 100,831,605 (-)NCBICHM1_1
T2T-CHM13v2.01100,035,014 - 100,097,802 (-)NCBIT2T-CHM13v2.0
Dbt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393116,306,776 - 116,343,630 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3116,306,719 - 116,343,630 (+)EnsemblGRCm39 Ensembl
GRCm383116,513,070 - 116,549,981 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3116,513,070 - 116,549,981 (+)EnsemblGRCm38mm10GRCm38
MGSCv373116,215,997 - 116,252,899 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363116,505,145 - 116,541,403 (+)NCBIMGSCv36mm8
Celera3122,940,011 - 122,977,028 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map350.37NCBI
Dbt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554354,973,830 - 5,017,816 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554354,975,664 - 5,005,126 (-)NCBIChiLan1.0ChiLan1.0
DBT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21126,778,646 - 126,854,613 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11125,936,695 - 126,011,918 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01102,852,585 - 102,907,146 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11101,566,152 - 101,621,850 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1101,567,551 - 101,621,850 (-)Ensemblpanpan1.1panPan2
DBT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1649,753,233 - 49,805,493 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl649,753,323 - 49,805,882 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha652,424,469 - 52,476,285 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0650,100,981 - 50,152,844 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl650,101,072 - 50,153,426 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1649,792,722 - 49,844,579 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0649,771,509 - 49,823,578 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0650,201,398 - 50,255,118 (+)NCBIUU_Cfam_GSD_1.0
Dbt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058110,537,454 - 110,580,910 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936748342,394 - 386,000 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936748342,655 - 386,017 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DBT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4117,875,002 - 117,936,612 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14117,884,657 - 117,924,006 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24129,512,220 - 129,548,961 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DBT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12033,088,452 - 33,157,693 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2033,088,496 - 33,140,403 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603824,899,712 - 24,968,926 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dbt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248573,056,781 - 3,138,396 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248573,056,799 - 3,138,430 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dbt
268 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:428
Count of miRNA genes:241
Interacting mature miRNAs:298
Transcripts:ENSRNOT00000020267
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat

Markers in Region
D2Wox8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22204,499,123 - 204,499,414 (+)MAPPERmRatBN7.2
Rnor_6.02219,581,163 - 219,581,453NCBIRnor6.0
Rnor_5.02237,636,409 - 237,636,701UniSTSRnor5.0
RGSC_v3.42212,776,691 - 212,776,982RGDRGSC3.4
RGSC_v3.42212,776,692 - 212,776,982UniSTSRGSC3.4
RGSC_v3.12212,739,445 - 212,739,736RGD
Celera2196,991,794 - 196,992,084UniSTS
RH 3.4 Map21480.5UniSTS
RH 3.4 Map21480.5RGD
RH 2.0 Map21055.8RGD
Cytogenetic Map2q41UniSTS
RH131391  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q41UniSTS
AI412898  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22204,510,231 - 204,510,324 (+)MAPPERmRatBN7.2
Rnor_6.02219,592,271 - 219,592,363NCBIRnor6.0
Rnor_5.02237,625,499 - 237,625,591UniSTSRnor5.0
RGSC_v3.42212,787,800 - 212,787,892UniSTSRGSC3.4
Celera2197,002,231 - 197,002,323UniSTS
RH 3.4 Map21468.3UniSTS
Cytogenetic Map2q41UniSTS
GDB:4585461  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215,113,078 - 5,113,543 (+)MAPPERmRatBN7.2
mRatBN7.22204,488,197 - 204,489,350 (+)MAPPERmRatBN7.2
Rnor_6.014,808,164 - 4,808,630NCBIRnor6.0
Rnor_6.02219,570,237 - 219,571,389NCBIRnor6.0
Rnor_5.016,469,160 - 6,469,626UniSTSRnor5.0
RGSC_v3.415,373,322 - 5,373,788UniSTSRGSC3.4
RGSC_v3.42212,765,766 - 212,766,918UniSTSRGSC3.4
Celera2196,980,884 - 196,982,036UniSTS
Cytogenetic Map2q41UniSTS
Cytogenetic Map1p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 34 11 8
Low 1 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000020267   ⟹   ENSRNOP00000020267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2204,481,737 - 204,510,609 (+)Ensembl
Rnor_6.0 Ensembl2219,563,783 - 219,592,650 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095859   ⟹   ENSRNOP00000086915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2204,488,637 - 204,510,609 (+)Ensembl
RefSeq Acc Id: NM_053312   ⟹   NP_445764
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82207,166,660 - 207,195,528 (+)NCBI
mRatBN7.22204,481,744 - 204,510,612 (+)NCBI
Rnor_6.02219,563,783 - 219,592,651 (+)NCBI
Rnor_5.02237,625,211 - 237,654,081 (-)NCBI
RGSC_v3.42212,759,312 - 212,788,180 (+)RGD
Celera2196,974,438 - 197,002,611 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445764 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66487 (Get FASTA)   NCBI Sequence Viewer  
  BAB32668 (Get FASTA)   NCBI Sequence Viewer  
  EDL82033 (Get FASTA)   NCBI Sequence Viewer  
  EDL82034 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020267
  ENSRNOP00000020267.4
  ENSRNOP00000086915.1
RefSeq Acc Id: NP_445764   ⟸   NM_053312
- UniProtKB: B2GV15 (UniProtKB/TrEMBL),   F7EMY8 (UniProtKB/TrEMBL),   A0A8I6A4P4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020267   ⟸   ENSRNOT00000020267
RefSeq Acc Id: ENSRNOP00000086915   ⟸   ENSRNOT00000095859
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GV15-F1-model_v2 AlphaFold B2GV15 1-482 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691707
Promoter ID:EPDNEW_R2232
Type:multiple initiation site
Name:Dbt_1
Description:dihydrolipoamide branched chain transacylase E2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02219,563,787 - 219,563,847EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68403 AgrOrtholog
BioCyc Gene G2FUF-51497 BioCyc
Ensembl Genes ENSRNOG00000015029 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020267 ENTREZGENE
  ENSRNOT00000020267.7 UniProtKB/TrEMBL
  ENSRNOT00000095859.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.100 UniProtKB/TrEMBL
  3.30.559.10 UniProtKB/TrEMBL
  4.10.320.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103882 IMAGE-MGC_LOAD
InterPro 2-oxoA_DH_lipoyl-BS UniProtKB/TrEMBL
  2-oxoacid_DH_actylTfrase UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/TrEMBL
  CAT-like_dom_sf UniProtKB/TrEMBL
  E3-bd_dom_sf UniProtKB/TrEMBL
  E3_bd UniProtKB/TrEMBL
  Single_hybrid_motif UniProtKB/TrEMBL
KEGG Report rno:29611 UniProtKB/TrEMBL
MGC_CLONE MGC:187991 IMAGE-MGC_LOAD
NCBI Gene 29611 ENTREZGENE
PANTHER DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX UniProtKB/TrEMBL
  LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam 2-oxoacid_dh UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/TrEMBL
  E3_binding UniProtKB/TrEMBL
PhenoGen Dbt PhenoGen
PROSITE BIOTINYL_LIPOYL UniProtKB/TrEMBL
  LIPOYL UniProtKB/TrEMBL
  PSBD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015029 RatGTEx
Superfamily-SCOP CoA-dependent acyltransferases UniProtKB/TrEMBL
  E3_bd UniProtKB/TrEMBL
  Hybrid_motif UniProtKB/TrEMBL
TIGR TC222156
UniProt A0A8I6A4P4 ENTREZGENE, UniProtKB/TrEMBL
  A6HV98_RAT UniProtKB/TrEMBL
  B2GV15 ENTREZGENE, UniProtKB/TrEMBL
  F7EMY8 ENTREZGENE, UniProtKB/TrEMBL
  Q99PU6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Dbt  dihydrolipoamide branched chain transacylase E2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization mitochondrial inner membrane 68231