Grm3 (glutamate metabotropic receptor 3) - Rat Genome Database

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Gene: Grm3 (glutamate metabotropic receptor 3) Rattus norvegicus
Analyze
Symbol: Grm3
Name: glutamate metabotropic receptor 3
RGD ID: 2744
Description: Enables group II metabotropic glutamate receptor activity and scaffold protein binding activity. Involved in modulation of chemical synaptic transmission. Located in astrocyte projection and axon. Orthologous to human GRM3 (glutamate metabotropic receptor 3); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutamate receptor, metabotropic 3; LOC689121; LOC689135; metabotropic glutamate receptor 3; mGluR3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2424,364,854 - 24,643,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl424,365,115 - 24,609,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx429,383,135 - 29,627,784 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0425,309,367 - 25,554,029 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0423,682,930 - 23,927,592 (+)NCBIRnor_WKY
Rnor_6.0421,316,761 - 21,567,561 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl421,317,695 - 21,560,490 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0421,395,468 - 21,492,672 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4420,745,424 - 22,118,097 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1420,888,668 - 22,118,011 (+)NCBI
Celera419,871,649 - 20,110,051 (+)NCBICelera
Cytogenetic Map4q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors. Lavialle M, etal., Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12915-9. doi: 10.1073/pnas.1100957108. Epub 2011 Jul 13.
4. Modulation of epileptiform burst frequency by the metabotropic glutamate receptor subtype mGluR3. Lea PM 4th and Sarvey JM, Epilepsy Res 2003 Mar;53(3):207-15.
5. [Levels of histamine in the tissues of the stomach and liver of non-pregnant and pregnant guinea pigs, their fetuses, in the blood of pregnant females and in fetal fluids]. Lipovskii SM Fiziol Zh SSSR Im I M Sechenova. 1975 Jan;61(1):90-5.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain. Ritter-Makinson SL, etal., Neuroscience. 2017 Jun 14;353:58-75. doi: 10.1016/j.neuroscience.2017.03.060. Epub 2017 Apr 7.
13. A family of metabotropic glutamate receptors. Tanabe Y, etal., Neuron 1992 Jan;8(1):169-79.
14. Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. Worst TJ, etal., J Neurosci Res 2005 May 15;80(4):529-38.
Additional References at PubMed
PMID:1298935   PMID:7965099   PMID:11591452   PMID:11850456   PMID:11891216   PMID:12074840   PMID:12098644   PMID:12363402   PMID:12746871   PMID:12887692   PMID:14663150   PMID:15030392  
PMID:15494036   PMID:15579147   PMID:15635057   PMID:15799084   PMID:15845577   PMID:15862522   PMID:16000629   PMID:16417588   PMID:16760343   PMID:16793029   PMID:17005860   PMID:17216195  
PMID:17224239   PMID:17401670   PMID:17402968   PMID:17630217   PMID:18021417   PMID:18035348   PMID:18804094   PMID:19255473   PMID:19374778   PMID:19429193   PMID:21198990   PMID:22245498  
PMID:22245662   PMID:22479593   PMID:22531751   PMID:22984605   PMID:24067361   PMID:24291464   PMID:25583490   PMID:26051401   PMID:26071959   PMID:27565411   PMID:28495373   PMID:29024663  
PMID:30005976   PMID:31050077   PMID:31710636  


Genomics

Comparative Map Data
Grm3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2424,364,854 - 24,643,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl424,365,115 - 24,609,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx429,383,135 - 29,627,784 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0425,309,367 - 25,554,029 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0423,682,930 - 23,927,592 (+)NCBIRnor_WKY
Rnor_6.0421,316,761 - 21,567,561 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl421,317,695 - 21,560,490 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0421,395,468 - 21,492,672 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4420,745,424 - 22,118,097 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1420,888,668 - 22,118,011 (+)NCBI
Celera419,871,649 - 20,110,051 (+)NCBICelera
Cytogenetic Map4q12NCBI
GRM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38786,643,909 - 86,864,879 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl786,643,909 - 86,864,879 (+)EnsemblGRCh38hg38GRCh38
GRCh37786,273,225 - 86,494,195 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36786,111,166 - 86,332,128 (+)NCBINCBI36Build 36hg18NCBI36
Build 34785,917,880 - 86,138,843NCBI
Celera780,977,204 - 81,198,167 (+)NCBICelera
Cytogenetic Map7q21.11-q21.12NCBI
HuRef780,884,478 - 81,105,436 (+)NCBIHuRef
CHM1_1786,203,231 - 86,424,248 (+)NCBICHM1_1
T2T-CHM13v2.0787,893,808 - 88,114,781 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2785,604,962 - 85,825,938 (+)NCBI
Grm3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3959,535,235 - 9,776,087 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl59,535,541 - 9,775,170 (-)EnsemblGRCm39 Ensembl
GRCm3859,485,236 - 9,725,352 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl59,485,541 - 9,725,170 (-)EnsemblGRCm38mm10GRCm38
MGSCv3759,485,236 - 9,725,352 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3659,491,242 - 9,731,358 (-)NCBIMGSCv36mm8
Celera59,402,805 - 9,643,075 (-)NCBICelera
Cytogenetic Map5A1NCBI
Grm3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955410104,242 - 184,921 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955410103,774 - 185,062 (-)NCBIChiLan1.0ChiLan1.0
GRM3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1792,279,079 - 92,500,553 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl792,400,728 - 92,500,553 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0778,621,634 - 78,842,532 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GRM3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11412,861,093 - 13,069,829 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1412,980,180 - 13,069,823 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1412,495,006 - 12,703,930 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01412,622,206 - 12,831,301 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11412,827,178 - 13,036,385 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01412,553,520 - 12,762,200 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01412,836,839 - 13,046,196 (+)NCBIUU_Cfam_GSD_1.0
Grm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511867,194,717 - 67,402,093 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936653392,855 - 553,498 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936653345,770 - 553,460 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRM3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl993,731,217 - 93,973,543 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1993,731,210 - 93,974,718 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29103,209,681 - 103,422,774 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRM3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12162,072,271 - 62,296,048 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2162,071,881 - 62,174,231 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604241,760,103 - 41,982,763 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grm3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473934,303,586 - 34,386,306 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473934,192,929 - 34,386,297 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grm3
1183 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:212
Count of miRNA genes:152
Interacting mature miRNAs:177
Transcripts:ENSRNOT00000007572
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat

Markers in Region
D4Got201  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2424,834,009 - 24,834,180 (+)MAPPERmRatBN7.2
Rnor_6.0421,786,139 - 21,786,309NCBIRnor6.0
Rnor_5.0421,717,503 - 21,717,673UniSTSRnor5.0
RGSC_v3.4421,252,921 - 21,253,091UniSTSRGSC3.4
Celera420,331,370 - 20,331,564UniSTS
Cytogenetic Map4q12UniSTS
D4Wox53  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,357,584 - 25,357,782 (+)MAPPERmRatBN7.2
Rnor_6.0422,339,947 - 22,340,144NCBIRnor6.0
Rnor_5.0422,276,508 - 22,276,705UniSTSRnor5.0
RGSC_v3.4421,796,313 - 21,796,510UniSTSRGSC3.4
Celera420,849,693 - 20,849,890UniSTS
Cytogenetic Map4q12UniSTS
D4Got255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2424,370,290 - 24,370,451 (+)MAPPERmRatBN7.2
Rnor_6.0421,322,871 - 21,323,031NCBIRnor6.0
Rnor_5.0421,256,235 - 21,256,395UniSTSRnor5.0
RGSC_v3.4420,750,600 - 20,750,760UniSTSRGSC3.4
Celera419,876,825 - 19,876,985UniSTS
Cytogenetic Map4q12UniSTS
D4Got287  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,020,540 - 25,020,656 (+)MAPPERmRatBN7.2
Rnor_6.0421,972,197 - 21,972,310NCBIRnor6.0
Rnor_5.0421,902,885 - 21,902,998UniSTSRnor5.0
RGSC_v3.4421,440,203 - 21,440,316UniSTSRGSC3.4
Celera420,518,533 - 20,518,646UniSTS
Cytogenetic Map4q12UniSTS
D4Ulb3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2424,882,891 - 24,883,065 (+)MAPPERmRatBN7.2
Rnor_6.0421,834,757 - 21,834,930NCBIRnor6.0
Rnor_5.0421,766,121 - 21,766,294UniSTSRnor5.0
RGSC_v3.4421,301,804 - 21,301,977UniSTSRGSC3.4
Celera420,380,315 - 20,380,488UniSTS
Cytogenetic Map4q12UniSTS
RH70765  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2712,244,100 - 12,244,891 (+)MAPPERmRatBN7.2
Rnor_6.0715,409,622 - 15,410,412NCBIRnor6.0
Rnor_5.0715,580,624 - 15,581,414UniSTSRnor5.0
RGSC_v3.4713,823,096 - 13,823,886UniSTSRGSC3.4
RGSC_v3.4421,694,148 - 21,694,268UniSTSRGSC3.4
Celera710,337,601 - 10,338,391UniSTS
Cytogenetic Map4q12UniSTS
RH139066  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,631,612 - 25,631,808 (+)MAPPERmRatBN7.2
Rnor_6.0422,617,843 - 22,618,038NCBIRnor6.0
Rnor_5.0422,549,391 - 22,549,586UniSTSRnor5.0
RGSC_v3.4421,512,279 - 21,512,474UniSTSRGSC3.4
Celera421,117,395 - 21,117,590UniSTS
RH 3.4 Map4151.9UniSTS
Cytogenetic Map4q12UniSTS
WI-18027  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2424,609,448 - 24,609,573 (+)MAPPERmRatBN7.2
Rnor_6.0421,560,135 - 21,560,259NCBIRnor6.0
Rnor_5.0421,492,317 - 21,492,441UniSTSRnor5.0
RGSC_v3.4422,117,742 - 22,117,866UniSTSRGSC3.4
Celera420,109,696 - 20,109,820UniSTS
Cytogenetic Map4q12UniSTS
RH133796  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,076,110 - 25,076,307 (+)MAPPERmRatBN7.2
mRatBN7.2425,093,692 - 25,093,889 (+)MAPPERmRatBN7.2
Rnor_6.0422,077,121 - 22,077,317NCBIRnor6.0
Rnor_5.0422,013,779 - 22,013,975UniSTSRnor5.0
RGSC_v3.4422,071,316 - 22,071,512UniSTSRGSC3.4
Celera420,571,456 - 20,571,652UniSTS
RH 3.4 Map4144.3UniSTS
Cytogenetic Map4q12UniSTS
RH142432  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,132,724 - 25,132,963 (+)MAPPERmRatBN7.2
Rnor_6.0422,115,881 - 22,116,119NCBIRnor6.0
Rnor_5.0422,052,703 - 22,052,941UniSTSRnor5.0
RGSC_v3.4422,024,059 - 22,024,297UniSTSRGSC3.4
Celera420,625,873 - 20,626,111UniSTS
Cytogenetic Map4q12UniSTS
RH144027  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2424,609,610 - 24,609,741 (+)MAPPERmRatBN7.2
Rnor_6.0421,560,297 - 21,560,427NCBIRnor6.0
Rnor_5.0421,492,479 - 21,492,609UniSTSRnor5.0
RGSC_v3.4422,117,904 - 22,118,034UniSTSRGSC3.4
Celera420,109,858 - 20,109,988UniSTS
RH 3.4 Map4119.6UniSTS
Cytogenetic Map4q12UniSTS
RH137636  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2424,923,422 - 24,923,670 (+)MAPPERmRatBN7.2
Rnor_6.0421,875,437 - 21,875,684NCBIRnor6.0
Rnor_5.0421,806,801 - 21,807,048UniSTSRnor5.0
RGSC_v3.4421,342,329 - 21,342,576UniSTSRGSC3.4
Celera420,420,864 - 20,421,111UniSTS
RH 3.4 Map4136.6UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map4q12-q13UniSTS
RH138123  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2424,932,604 - 24,932,820 (+)MAPPERmRatBN7.2
Rnor_6.0421,884,619 - 21,884,834NCBIRnor6.0
Rnor_5.0421,815,983 - 21,816,198UniSTSRnor5.0
RGSC_v3.4421,351,511 - 21,351,726UniSTSRGSC3.4
Celera420,430,046 - 20,430,261UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map4q12-q13UniSTS
RH139646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2424,951,018 - 24,951,200 (+)MAPPERmRatBN7.2
Rnor_6.0421,903,031 - 21,903,212NCBIRnor6.0
Rnor_5.0421,834,395 - 21,834,576UniSTSRnor5.0
RGSC_v3.4421,369,924 - 21,370,105UniSTSRGSC3.4
Celera420,448,467 - 20,448,648UniSTS
RH 3.4 Map4142.2UniSTS
RH 3.4 Map4144.6UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map4q12-q13UniSTS
RH140325  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,599,222 - 25,599,412 (+)MAPPERmRatBN7.2
Rnor_6.0422,586,439 - 22,586,628NCBIRnor6.0
Rnor_5.0422,518,099 - 22,518,288UniSTSRnor5.0
RGSC_v3.4421,546,224 - 21,546,413UniSTSRGSC3.4
Celera421,085,038 - 21,085,227UniSTS
RH 3.4 Map4151.0UniSTS
Cytogenetic Map4q12UniSTS
RH141561  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2424,925,306 - 24,925,490 (+)MAPPERmRatBN7.2
Rnor_6.0421,877,321 - 21,877,504NCBIRnor6.0
Rnor_5.0421,808,685 - 21,808,868UniSTSRnor5.0
RGSC_v3.4421,344,213 - 21,344,396UniSTSRGSC3.4
Celera420,422,748 - 20,422,931UniSTS
RH 3.4 Map4136.8UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map4q12-q13UniSTS
RH142062  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,607,755 - 25,607,955 (+)MAPPERmRatBN7.2
Rnor_6.0422,594,972 - 22,595,167NCBIRnor6.0
Rnor_5.0422,526,632 - 22,526,827UniSTSRnor5.0
RGSC_v3.4421,537,681 - 21,537,880UniSTSRGSC3.4
Celera421,093,571 - 21,093,770UniSTS
Cytogenetic Map4q12UniSTS
Grm3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2424,365,031 - 24,365,096 (+)MAPPERmRatBN7.2
Rnor_6.0421,317,612 - 21,317,676NCBIRnor6.0
Rnor_5.0421,250,976 - 21,251,040UniSTSRnor5.0
RGSC_v3.4420,745,341 - 20,745,405UniSTSRGSC3.4
Celera419,871,566 - 19,871,630UniSTS
Cytogenetic Map4q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 56 4 4
Low 3 2 2 18 14 27 7
Below cutoff 2 14 23 12 13 12 7 7 12 10 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007572   ⟹   ENSRNOP00000007572
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl424,365,115 - 24,609,804 (+)Ensembl
Rnor_6.0 Ensembl421,317,695 - 21,560,490 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089747   ⟹   ENSRNOP00000069396
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl424,365,115 - 24,609,449 (+)Ensembl
Rnor_6.0 Ensembl421,462,779 - 21,555,154 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109555   ⟹   ENSRNOP00000096683
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl424,365,115 - 24,609,449 (+)Ensembl
RefSeq Acc Id: NM_001105712   ⟹   NP_001099182
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2424,365,115 - 24,609,804 (+)NCBI
Rnor_6.0421,317,695 - 21,560,490 (+)NCBI
Rnor_5.0421,395,468 - 21,492,672 (+)NCBI
RGSC_v3.4420,745,424 - 22,118,097 (+)RGD
Celera419,871,649 - 20,110,051 (+)RGD
Sequence:
RefSeq Acc Id: XM_008762682   ⟹   XP_008760904
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2424,364,854 - 24,609,801 (+)NCBI
Rnor_6.0421,316,761 - 21,567,561 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592440   ⟹   XP_017447929
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2424,499,144 - 24,609,801 (+)NCBI
Rnor_6.0421,456,289 - 21,567,561 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107009   ⟹   XP_038962937
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2424,364,854 - 24,609,801 (+)NCBI
RefSeq Acc Id: XM_039107010   ⟹   XP_038962938
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2424,364,854 - 24,609,801 (+)NCBI
RefSeq Acc Id: XM_039107011   ⟹   XP_038962939
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2424,364,854 - 24,609,801 (+)NCBI
RefSeq Acc Id: XM_039107012   ⟹   XP_038962940
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2424,364,854 - 24,609,801 (+)NCBI
RefSeq Acc Id: XM_039107013   ⟹   XP_038962941
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2424,364,854 - 24,609,345 (+)NCBI
RefSeq Acc Id: XM_039107014   ⟹   XP_038962942
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2424,364,854 - 24,643,972 (+)NCBI
RefSeq Acc Id: XM_039107015   ⟹   XP_038962943
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2424,364,854 - 24,609,770 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001099182   ⟸   NM_001105712
- Peptide Label: precursor
- UniProtKB: P31422 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008760904   ⟸   XM_008762682
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GM70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447929   ⟸   XM_017592440
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GM70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069396   ⟸   ENSRNOT00000089747
RefSeq Acc Id: ENSRNOP00000007572   ⟸   ENSRNOT00000007572
RefSeq Acc Id: XP_038962942   ⟸   XM_039107014
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038962937   ⟸   XM_039107009
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GM70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962938   ⟸   XM_039107010
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GM70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962939   ⟸   XM_039107011
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GM70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962940   ⟸   XM_039107012
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GM70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962943   ⟸   XM_039107015
- Peptide Label: isoform X4
- UniProtKB: P31422 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038962941   ⟸   XM_039107013
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JV93 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000096683   ⟸   ENSRNOT00000109555
Protein Domains
G_PROTEIN_RECEP_F3_4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31422-F1-model_v2 AlphaFold P31422 1-879 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2744 AgrOrtholog
BIND 144396
BioCyc Gene G2FUF-45851 BioCyc
Ensembl Genes ENSRNOG00000005519 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007572 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000069396 ENTREZGENE
  ENSRNOP00000069396.1 UniProtKB/TrEMBL
  ENSRNOP00000096683 ENTREZGENE
  ENSRNOP00000096683.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007572 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000089747 ENTREZGENE
  ENSRNOT00000089747.2 UniProtKB/TrEMBL
  ENSRNOT00000109555 ENTREZGENE
  ENSRNOT00000109555.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24416 UniProtKB/Swiss-Prot
NCBI Gene 24416 ENTREZGENE
Pfam 7tm_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCD3G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grm3 PhenoGen
PRINTS GPCRMGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPC3R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JV93 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GM70 ENTREZGENE, UniProtKB/TrEMBL
  GRM3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Grm3  glutamate metabotropic receptor 3  Grm3  glutamate receptor, metabotropic 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-29 Grm3  glutamate receptor, metabotropic 3  LOC689135  similar to Metabotropic glutamate receptor 3 precursor (mGluR3)  Data Merged 737654 PROVISIONAL
2013-03-29 Grm3  glutamate receptor, metabotropic 3  LOC689121  hypothetical protein LOC689121  Data Merged 737654 PROVISIONAL
2006-11-20 LOC689121  hypothetical protein LOC689121      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC689135  similar to Metabotropic glutamate receptor 3 precursor (mGluR3)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Grm3  glutamate receptor, metabotropic 3    Glutamate receptor, metabotropic 3  Name updated 625702 APPROVED
2002-06-10 Grm3  Glutamate receptor, metabotropic 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript mRNA downregulated in frontal cortex of AA rat strain compared to ANA rat strain 1358772