Bmp2 (bone morphogenetic protein 2) - Rat Genome Database

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Gene: Bmp2 (bone morphogenetic protein 2) Rattus norvegicus
Symbol: Bmp2
Name: bone morphogenetic protein 2
RGD ID: 2211
Description: Enables growth factor activity; identical protein binding activity; and protein domain specific binding activity. Involved in several processes, including BMP signaling pathway; cellular response to mechanical stimulus; and response to retinoic acid. Acts upstream of or within positive regulation of neurogenesis and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; extracellular space; and vesicle. Part of protein-containing complex. Human ortholog(s) of this gene implicated in bone disease (multiple); hemochromatosis type 1; otosclerosis; prostate cancer; and tooth agenesis. Orthologous to human BMP2 (bone morphogenetic protein 2); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; basal cell carcinoma pathway; Hedgehog signaling pathway; INTERACTS WITH (20S)-ginsenoside Rg3; (R)-mevalonic acid; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BMP-2; BMP-2A; bone morphogenetic protein 2A
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.23120,812,660 - 120,822,579 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3120,812,882 - 120,821,397 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3124,714,198 - 124,722,859 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03133,321,871 - 133,330,571 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03130,970,379 - 130,979,043 (+)NCBIRnor_WKY
Rnor_6.03126,335,963 - 126,346,771 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3126,335,863 - 126,346,318 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03132,822,005 - 132,832,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43121,372,692 - 121,381,236 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13121,278,264 - 121,286,806 (+)NCBI
Celera3119,596,986 - 119,605,358 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(20S)-ginsenoside Rg3  (EXP)
(R)-adrenaline  (ISO)
(R)-mevalonic acid  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxypsoralen  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP)
atorvastatin calcium  (ISO)
aucubin  (ISO)
azadirachtin A  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
beta-D-glucosamine  (EXP)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cerivastatin  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dichromium trioxide  (ISO)
Didecyldimethylammonium  (ISO)
dioxygen  (EXP,ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
farnesyl diphosphate  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
gamma-aminobutyric acid  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
ginsenoside Rb1  (EXP)
glucose  (EXP,ISO)
glycerol 2-phosphate  (EXP,ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (EXP)
hesperidin  (EXP)
icariin  (EXP,ISO)
imperatorin  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP,ISO)
letrozole  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
LY294002  (ISO)
maneb  (ISO)
menaquinone  (EXP)
menaquinone-4  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mevastatin  (ISO)
mitomycin C  (ISO)
Morroniside  (EXP,ISO)
Muraglitazar  (EXP)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (EXP)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naringin  (EXP,ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
octreotide  (ISO)
oxaliplatin  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pasireotide  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phylloquinone  (EXP)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
Rebamipide  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tadalafil  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tripotassium phosphate  (EXP)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vorinostat  (ISO)
warfarin  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ameloblast differentiation  (IEA,ISO)
animal organ morphogenesis  (ISO)
aortic valve development  (IEA,ISO)
astrocyte differentiation  (IEA,ISO)
atrioventricular canal morphogenesis  (IEA,ISO)
atrioventricular valve morphogenesis  (IEA,ISO)
BMP signaling pathway  (IBA,IDA,ISO,ISS)
BMP signaling pathway involved in heart development  (IEA,ISO)
BMP signaling pathway involved in heart induction  (ISO,ISS)
bone development  (IEA,ISO)
bone mineralization  (IEA,ISO)
bone mineralization involved in bone maturation  (ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
cardiac atrium formation  (IEA,ISO)
cardiac epithelial to mesenchymal transition  (IEA,ISO)
cardiac jelly development  (IEA,ISO)
cardiac muscle cell differentiation  (IEA,ISO)
cardiac muscle tissue morphogenesis  (IEA,ISO)
cardiocyte differentiation  (ISO)
cell fate commitment  (IEA,ISO)
cellular response to BMP stimulus  (IEP,ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to organic cyclic compound  (IEA,ISO)
chondrocyte differentiation  (IEA,ISO)
corticotropin hormone secreting cell differentiation  (IEA,ISO)
embryonic heart tube anterior/posterior pattern specification  (IEA,ISO)
endocardial cushion formation  (IEA,ISO)
endocardial cushion morphogenesis  (ISO)
epithelial to mesenchymal transition  (ISO,ISS)
gene expression  (ISO)
heart development  (ISO)
in utero embryonic development  (IEA,ISO)
inflammatory response  (IEA,ISO)
inner ear development  (IEA,ISO)
mesenchymal cell differentiation  (ISO,ISS)
mesenchymal cell proliferation involved in ureteric bud development  (IEA,ISO)
mesenchyme development  (ISO)
negative regulation of aldosterone biosynthetic process  (IEA,ISO)
negative regulation of calcium-independent cell-cell adhesion  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cardiac muscle cell differentiation  (ISO,ISS)
negative regulation of cell cycle  (ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of cortisol biosynthetic process  (IEA,ISO)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of insulin-like growth factor receptor signaling pathway  (IEA,ISO)
negative regulation of MAP kinase activity  (IEA,ISO)
negative regulation of muscle cell differentiation  (ISO)
negative regulation of smooth muscle cell proliferation  (IEA,ISO)
negative regulation of steroid biosynthetic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,ISO,ISS)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
negative regulation of Wnt signaling pathway involved in heart development  (ISO,ISS)
Notch signaling pathway  (IEA,ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
osteoclast differentiation  (IEA,ISO)
ovulation cycle  (IEP)
pathway-restricted SMAD protein phosphorylation  (IEA,ISO)
pericardium development  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of astrocyte differentiation  (IEA,ISO)
positive regulation of bone mineralization  (ISO,ISS)
positive regulation of bone mineralization involved in bone maturation  (ISO,ISS)
positive regulation of cartilage development  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-binding transcription factor activity  (IEA,ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell proliferation  (ISO,ISS)
positive regulation of epithelial cell differentiation  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of extracellular matrix constituent secretion  (IEA,ISO)
positive regulation of fat cell differentiation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of neurogenesis  (IDA)
positive regulation of neuron differentiation  (IEA,ISO)
positive regulation of odontogenesis  (IEA,ISO)
positive regulation of ossification  (ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of osteoblast proliferation  (IEA,ISO)
positive regulation of p38MAPK cascade  (IEA,ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IBA,ISO,ISS)
positive regulation of peroxisome proliferator activated receptor signaling pathway  (IEA,ISO)
positive regulation of phosphatase activity  (IEA,ISO)
positive regulation of protein binding  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of SMAD protein signal transduction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO,ISS)
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus  (IEA,ISO)
positive regulation of Wnt signaling pathway  (ISO)
positive regulation of Wnt signaling pathway by BMP signaling pathway  (IEA,ISO)
protein destabilization  (IEA,ISO)
protein phosphorylation  (ISO)
proteoglycan metabolic process  (IEA,ISO)
regulation of DNA-templated transcription  (ISO)
regulation of odontogenesis of dentin-containing tooth  (IEA,ISO)
response to bacterium  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to mechanical stimulus  (IEP)
response to retinoic acid  (IEP)
SMAD protein signal transduction  (IBA,ISO,ISS)
telencephalon development  (ISO)
telencephalon regionalization  (IEA,ISO)
thyroid-stimulating hormone-secreting cell differentiation  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
Wnt signaling pathway  (IEA,ISO)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Enhancement of bone repair with a helper-dependent adenoviral transfer of bone morphogenetic protein-2. Abe N, etal., Biochem Biophys Res Commun 2002 Sep 27;297(3):523-7.
2. Bone morphogenetic protein-2 and -4 limit the number of enteric neurons but promote development of a TrkC-expressing neurotrophin-3-dependent subset. Chalazonitis A, etal., J Neurosci 2004 Apr 28;24(17):4266-82.
3. Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer. Doak SH, etal., Cancer Genet Cytogenet. 2007 Jul 15;176(2):161-5.
4. Effect of stretching stress on gene transcription related to early-phase differentiation in rat periodontal ligament cells. Enokiya Y, etal., Bull Tokyo Dent Coll. 2010;51(3):129-37.
5. Recombinant bone morphogenetic protein (BMP)-2 regulates costochondral growth plate chondrocytes and induces expression of BMP-2 and BMP-4 in a cell maturation-dependent manner. Erickson DM, etal., J Orthop Res. 1997 May;15(3):371-80.
6. Analysis of spatial and temporal expression patterns of bone morphogenetic protein family members in the rat uterus over the estrous cycle. Erickson GF, etal., J Endocrinol. 2004 Aug;182(2):203-17.
7. Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): comparison of the structures and promoter regions of BMP-2 and BMP-4 genes. Feng JQ, etal., Biochim Biophys Acta 1994 Jun 21;1218(2):221-4.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells. Gazit D, etal., Mol Endocrinol. 1993 Feb;7(2):189-98.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Horvath LG, etal., Prostate. 2004 May 15;59(3):234-42.
12. Fibrodysplasia ossificans progressiva: a clue from the fly? Kaplan FS, etal., Calcif Tissue Int 1990 Aug;47(2):117-25.
13. Synergistic effect of fibroblast growth factor-4 in ectopic bone formation induced by bone morphogenetic protein-2. Kubota K, etal., Bone 2002 Oct;31(4):465-71.
14. BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression. Lee MH, etal., J Biol Chem 2003 Sep 5;278(36):34387-94. Epub 2003 Jun 18.
15. Zhonghua nan ke xue = National journal of andrology Li ZL, etal., Zhonghua Nan Ke Xue. 2006 Feb;12(2):126-8, 132.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Phenotype characterization and sequence analysis of BMP2 and BMP4 variants in two Mexican families with oligodontia. Mu Y, etal., Genet Mol Res. 2012 Nov 28;11(4):4110-20. doi: 10.4238/2012.September.25.5.
18. Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins. Nahar NN, etal., J Bone Miner Metab. 2008;26(5):514-9. Epub 2008 Aug 30.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Expression of bone morphogenic proteins and receptors at the injured growth plate cartilage in young rats. Ngo TQ, etal., J Histochem Cytochem. 2006 Aug;54(8):945-54. Epub 2006 May 1.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord. Sandner B, etal., Stem Cell Res. 2013 Sep;11(2):758-71. doi: 10.1016/j.scr.2013.05.003. Epub 2013 May 16.
28. Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis. Sato M, etal., J Bone Miner Res. 1999 Jul;14(7):1084-95.
29. Association of bone morphogenetic proteins with otosclerosis. Schrauwen I, etal., J Bone Miner Res. 2008 Apr;23(4):507-16.
30. Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Shah NM, etal., Cell. 1996 May 3;85(3):331-43.
31. Localization of bone morphogenetic proteins (BMPs)-2, -4, and -6 within megakaryocytes and platelets. Sipe JB, etal., Bone. 2004 Dec;35(6):1316-22.
32. Matrix Gla protein (MGP) and bone morphogenetic protein-2 in aortic calcified lesions of aging rats. Sweatt A, etal., J Thromb Haemost. 2003 Jan;1(1):178-85.
33. Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Takahashi H, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L450-8. Epub 2005 Dec 16.
34. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
35. Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Valdes AM, etal., Arthritis Rheum. 2004 Aug;50(8):2497-507.
36. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. Xiong DH, etal., J Bone Miner Res. 2006 Nov;21(11):1678-95.
Additional References at PubMed
PMID:1468569   PMID:3201241   PMID:7811286   PMID:7848824   PMID:8653785   PMID:8769660   PMID:8898212   PMID:9187146   PMID:9213002   PMID:9244299   PMID:9463347   PMID:9585504  
PMID:9693150   PMID:9769173   PMID:9786991   PMID:10391928   PMID:10486560   PMID:10684250   PMID:11502704   PMID:11719201   PMID:12151307   PMID:12421925   PMID:12782312   PMID:14623234  
PMID:14627707   PMID:15110716   PMID:15150273   PMID:15175325   PMID:15254224   PMID:15322112   PMID:15358784   PMID:15383550   PMID:15525533   PMID:15565649   PMID:15657444   PMID:15671031  
PMID:15695507   PMID:15820682   PMID:15851600   PMID:15882580   PMID:15886483   PMID:15925496   PMID:15975920   PMID:16049014   PMID:16099986   PMID:16109715   PMID:16194878   PMID:16243309  
PMID:16314491   PMID:16433617   PMID:16604073   PMID:16935278   PMID:16996588   PMID:17001659   PMID:17158861   PMID:17171790   PMID:17202865   PMID:17244894   PMID:17415742   PMID:17472960  
PMID:17473173   PMID:17953369   PMID:17992660   PMID:18070548   PMID:18184661   PMID:18295562   PMID:18313401   PMID:18326817   PMID:18335997   PMID:18380969   PMID:18436533   PMID:18545679  
PMID:18600149   PMID:18832104   PMID:19103752   PMID:19208758   PMID:19213727   PMID:19584291   PMID:19617624   PMID:19664780   PMID:19669850   PMID:19736317   PMID:19852960   PMID:20019778  
PMID:20042692   PMID:20048761   PMID:20065295   PMID:20576608   PMID:20675382   PMID:20843790   PMID:20882582   PMID:20886619   PMID:20890042   PMID:20926379   PMID:20936960   PMID:20939479  
PMID:21043834   PMID:21049555   PMID:21145505   PMID:21157119   PMID:21311046   PMID:21324897   PMID:21350216   PMID:21415150   PMID:21520255   PMID:21590708   PMID:21592969   PMID:21624478  
PMID:21636885   PMID:21737358   PMID:21795542   PMID:21873793   PMID:22227436   PMID:22363399   PMID:22450430   PMID:22508088   PMID:22540193   PMID:22556155   PMID:22579779   PMID:22674456  
PMID:22705305   PMID:22829700   PMID:22861354   PMID:22994418   PMID:23010719   PMID:23012479   PMID:23088504   PMID:23238867   PMID:23359400   PMID:23447035   PMID:23620751   PMID:23632743  
PMID:23821199   PMID:23822814   PMID:24111806   PMID:24167632   PMID:24306516   PMID:24406215   PMID:24416413   PMID:24464097   PMID:24648278   PMID:24682653   PMID:24866243   PMID:25100727  
PMID:25218476   PMID:25446167   PMID:25659106   PMID:25677945   PMID:25725805   PMID:25823394   PMID:25896232   PMID:26308798   PMID:26345843   PMID:26352281   PMID:26404484   PMID:26763079  
PMID:26772960   PMID:26797522   PMID:26931551   PMID:27178636   PMID:27477499   PMID:27771997   PMID:27885436   PMID:28124060   PMID:28256809   PMID:28457943   PMID:28595186   PMID:28642034  
PMID:29785051   PMID:29850574   PMID:30700748   PMID:30937700   PMID:31002144   PMID:31432121   PMID:31694396   PMID:31737960   PMID:31746352   PMID:32131378   PMID:32830897   PMID:34266353  
PMID:35594008   PMID:35981926   PMID:36613483  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.23120,812,660 - 120,822,579 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3120,812,882 - 120,821,397 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3124,714,198 - 124,722,859 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03133,321,871 - 133,330,571 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03130,970,379 - 130,979,043 (+)NCBIRnor_WKY
Rnor_6.03126,335,963 - 126,346,771 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3126,335,863 - 126,346,318 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03132,822,005 - 132,832,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43121,372,692 - 121,381,236 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13121,278,264 - 121,286,806 (+)NCBI
Celera3119,596,986 - 119,605,358 (+)NCBICelera
Cytogenetic Map3q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38206,767,686 - 6,780,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl206,767,686 - 6,780,246 (+)EnsemblGRCh38hg38GRCh38
GRCh37206,748,333 - 6,760,893 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36206,696,745 - 6,708,910 (+)NCBINCBI36Build 36hg18NCBI36
Build 34206,697,206 - 6,707,769NCBI
Celera206,819,903 - 6,832,070 (+)NCBICelera
Cytogenetic Map20p12.3NCBI
HuRef206,705,637 - 6,717,811 (+)NCBIHuRef
CHM1_1206,748,804 - 6,760,970 (+)NCBICHM1_1
T2T-CHM13v2.0206,808,871 - 6,821,444 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392133,394,079 - 133,404,816 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2133,394,079 - 133,404,805 (+)EnsemblGRCm39 Ensembl
GRCm382133,552,159 - 133,562,896 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2133,552,159 - 133,562,885 (+)EnsemblGRCm38mm10GRCm38
MGSCv372133,378,935 - 133,388,621 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362133,244,640 - 133,254,326 (+)NCBIMGSCv36mm8
Celera2134,774,971 - 134,784,597 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map265.21NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541517,048,030 - 17,060,181 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541517,048,374 - 17,058,172 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1206,546,173 - 6,558,627 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl206,546,173 - 6,558,610 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0206,765,161 - 6,777,728 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12415,199,667 - 15,211,509 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2415,200,291 - 15,212,217 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2415,022,880 - 15,034,779 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02415,603,929 - 15,615,829 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2415,603,981 - 15,615,810 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12415,210,353 - 15,222,261 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02415,320,936 - 15,332,831 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02415,650,158 - 15,662,056 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640163,997,168 - 164,008,273 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648512,428,710 - 12,439,454 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493648512,428,765 - 12,439,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1715,749,835 - 15,761,195 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11715,750,487 - 15,762,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21717,052,609 - 17,064,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1231,349,394 - 31,361,227 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl231,348,808 - 31,360,901 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607113,190,629 - 13,202,875 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247417,706,236 - 7,719,484 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247417,706,205 - 7,717,677 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Bmp2
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:85
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000028904, ENSRNOT00000073728
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3115638168135181505Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23120,821,085 - 120,821,279 (+)MAPPERmRatBN7.2
Rnor_6.03126,344,388 - 126,344,581NCBIRnor6.0
Rnor_5.03132,830,406 - 132,830,599UniSTSRnor5.0
RGSC_v3.43121,380,922 - 121,381,115UniSTSRGSC3.4
Celera3119,605,044 - 119,605,237UniSTS
RH 3.4 Map31052.5UniSTS
Cytogenetic Map3q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23120,820,845 - 120,820,970 (+)MAPPERmRatBN7.2
Rnor_6.03126,344,148 - 126,344,272NCBIRnor6.0
Rnor_5.03132,830,166 - 132,830,290UniSTSRnor5.0
RGSC_v3.43121,380,682 - 121,380,806UniSTSRGSC3.4
Celera3119,604,804 - 119,604,928UniSTS
Cytogenetic Map3q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23120,820,783 - 120,821,024 (+)MAPPERmRatBN7.2
Rnor_6.03126,344,086 - 126,344,326NCBIRnor6.0
Rnor_5.03132,830,104 - 132,830,344UniSTSRnor5.0
RGSC_v3.43121,380,620 - 121,380,860UniSTSRGSC3.4
Celera3119,604,742 - 119,604,982UniSTS
Cytogenetic Map3q36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 10 2 2 2 4 10
Low 2 32 49 39 13 39 7 9 74 30 24 11 7
Below cutoff 1 6 6 1 2 1 6 1


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028904   ⟹   ENSRNOP00000028904
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3126,335,863 - 126,346,318 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108290   ⟹   ENSRNOP00000081600
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3120,812,882 - 120,821,397 (+)Ensembl
RefSeq Acc Id: NM_017178   ⟹   NP_058874
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.23120,812,687 - 120,821,400 (+)NCBI
Rnor_6.03126,336,185 - 126,344,702 (+)NCBI
Rnor_5.03132,822,005 - 132,832,789 (+)NCBI
RGSC_v3.43121,372,692 - 121,381,236 (+)RGD
Celera3119,596,986 - 119,605,358 (+)RGD
RefSeq Acc Id: XM_039104435   ⟹   XP_038960363
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23120,812,660 - 120,822,579 (+)NCBI
Protein Sequences
Protein RefSeqs NP_058874 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960363 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA81088 (Get FASTA)   NCBI Sequence Viewer  
  EDL80282 (Get FASTA)   NCBI Sequence Viewer  
  EDL80283 (Get FASTA)   NCBI Sequence Viewer  
  P49001 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058874   ⟸   NM_017178
- Peptide Label: precursor
- UniProtKB: G3V8W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028904   ⟸   ENSRNOT00000028904
RefSeq Acc Id: XP_038960363   ⟸   XM_039104435
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000081600   ⟸   ENSRNOT00000108290
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49001-F1-model_v2 AlphaFold P49001 1-393 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692461
Promoter ID:EPDNEW_R2984
Type:single initiation site
Description:bone morphogenetic protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.03126,335,794 - 126,335,854EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2211 AgrOrtholog
BioCyc Gene G2FUF-47749 BioCyc
Ensembl Genes ENSRNOG00000021276 Ensembl
  ENSRNOG00000071010 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000081600 ENTREZGENE
  ENSRNOP00000081600.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000108290 ENTREZGENE
  ENSRNOT00000108290.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29373 UniProtKB/Swiss-Prot
  PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bmp2 PhenoGen
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217827
UniProt BMP2_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Bmp2  bone morphogenetic protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in spleen 69777
gene_function growth factor 631753
gene_homology has 90% identity to human protein 69777
gene_process induces ectopic bone formation 631753
gene_product member of the transforming growth factor beta superfamily 69777
gene_transcript transcript has 3 exons 69777
gene_transcript 11kb 69777