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Gene: Pth (parathyroid hormone) Rattus norvegicus
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Symbol: Pth
Name: parathyroid hormone
RGD ID: 3440
Description: Exhibits hormone activity; peptide hormone receptor binding activity; and type 1 parathyroid hormone receptor binding activity. Involved in several processes, including intracellular signal transduction; negative regulation of chondrocyte differentiation; and regulation of bone mineralization. Localizes to extracellular space. Used to study several diseases, including chronic kidney disease; hyperphosphatemia; nephrocalcinosis; osteoporosis; and secondary hyperparathyroidism. Biomarker of autosomal dominant hypocalcemia; kidney failure (multiple); osteoporosis; and secondary hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including chronic kidney disease; diabetes mellitus (multiple); familial isolated hypoparathyroidism; hyperphosphatemia; and secondary hyperparathyroidism. Orthologous to human PTH (parathyroid hormone); PARTICIPATES IN parathyroid hormone signaling pathway; INTERACTS WITH 24,25-Dihydroxyvitamin D; 3',5'-cyclic AMP; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: hypothalamic parathyroid hormone; parathyrin; PTH-(1-84); Pth1; Pthr1
Orthologs:
Homo sapiens (human) : PTH (parathyroid hormone)  HGNC  Alliance
Mus musculus (house mouse) : Pth (parathyroid hormone)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pth (parathyroid hormone)
Pan paniscus (bonobo/pygmy chimpanzee) : PTH (parathyroid hormone)
Canis lupus familiaris (dog) : PTH (parathyroid hormone)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pth (parathyroid hormone)
Sus scrofa (pig) : PTH (parathyroid hormone)
Chlorocebus sabaeus (African green monkey) : PTH (parathyroid hormone)
Heterocephalus glaber (naked mole-rat) : Pth (parathyroid hormone)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01178,215,829 - 178,218,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,215,829 - 178,218,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01185,183,456 - 185,186,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41171,240,596 - 171,243,528 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11171,360,529 - 171,363,462 (-)NCBI
Celera1165,378,267 - 165,381,199 (-)NCBICelera
Cytogenetic Map1q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pth
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3440
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.