PTH (parathyroid hormone) - Rat Genome Database

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Gene: PTH (parathyroid hormone) Canis lupus familiaris
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Symbol: PTH
Name: parathyroid hormone
RGD ID: 12368635
Description: ENCODES a protein that exhibits parathyroid hormone receptor binding (ortholog); peptide hormone receptor binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); bone mineralization (ortholog); calcium ion homeostasis (ortholog); PARTICIPATES IN parathyroid hormone signaling pathway; ASSOCIATED WITH Albuminuria (ortholog); anemia (ortholog); Animal Disease Models (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH masitinib; Maxacalcitol
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: parathyrin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12136,417,062 - 36,419,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2136,417,058 - 36,419,967 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2135,920,892 - 35,923,798 (-)NCBI
ROS_Cfam_1.02137,300,338 - 37,303,244 (-)NCBI
UMICH_Zoey_3.12136,558,731 - 36,561,637 (-)NCBI
UNSW_CanFamBas_1.02136,734,945 - 36,737,853 (-)NCBI
UU_Cfam_GSD_1.02137,024,013 - 37,026,919 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
masitinib  (EXP)
Maxacalcitol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of phospholipase C activity  (IEA)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
bone mineralization  (ISO)
calcium ion homeostasis  (ISO)
cell-cell signaling  (IBA,ISO)
cellular calcium ion homeostasis  (IEA,ISO)
cellular macromolecule biosynthetic process  (IEA,ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
magnesium ion homeostasis  (IEA)
negative regulation of apoptotic process in bone marrow cell  (IEA,ISO)
negative regulation of bone mineralization involved in bone maturation  (ISO)
negative regulation of chondrocyte differentiation  (ISO)
negative regulation of gene expression  (IEA)
phosphate ion homeostasis  (IEA)
positive regulation of bone mineralization  (IEA,ISO)
positive regulation of cell proliferation in bone marrow  (IEA,ISO)
positive regulation of glucose import  (ISS)
positive regulation of glycogen biosynthetic process  (ISS)
positive regulation of inositol phosphate biosynthetic process  (IEA)
positive regulation of ossification  (ISO)
positive regulation of osteoclast proliferation  (IEA,ISO)
positive regulation of signal transduction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of gene expression  (ISO)
response to cadmium ion  (ISO)
response to ethanol  (ISO)
response to fibroblast growth factor  (ISO)
response to lead ion  (ISO)
response to nutrient levels  (ISO)
response to parathyroid hormone  (ISO)
response to vitamin D  (ISO)
response to xenobiotic stimulus  (ISO)
Rho protein signal transduction  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:7642102   PMID:12929937  


Genomics

Comparative Map Data
PTH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12136,417,062 - 36,419,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2136,417,058 - 36,419,967 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2135,920,892 - 35,923,798 (-)NCBI
ROS_Cfam_1.02137,300,338 - 37,303,244 (-)NCBI
UMICH_Zoey_3.12136,558,731 - 36,561,637 (-)NCBI
UNSW_CanFamBas_1.02136,734,945 - 36,737,853 (-)NCBI
UU_Cfam_GSD_1.02137,024,013 - 37,026,919 (-)NCBI
PTH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1113,492,054 - 13,496,181 (-)EnsemblGRCh38hg38GRCh38
GRCh381113,492,054 - 13,496,181 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371113,513,601 - 13,517,728 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361113,470,177 - 13,474,143 (-)NCBINCBI36hg18NCBI36
Build 341113,470,177 - 13,474,143NCBI
Celera1113,639,772 - 13,643,738 (-)NCBI
Cytogenetic Map11p15.3NCBI
HuRef1113,193,715 - 13,197,681 (-)NCBIHuRef
CHM1_11113,512,571 - 13,516,537 (-)NCBICHM1_1
Pth
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397112,984,783 - 112,987,879 (-)NCBIGRCm39mm39
GRCm39 Ensembl7112,984,787 - 112,987,777 (-)Ensembl
GRCm387113,385,576 - 113,388,672 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7113,385,580 - 113,388,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv377120,529,090 - 120,532,087 (-)NCBIGRCm37mm9NCBIm37
MGSCv367113,176,759 - 113,179,753 (-)NCBImm8
Celera7113,358,705 - 113,361,703 (-)NCBICelera
Cytogenetic Map7F1NCBI
cM Map759.19NCBI
Pth
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21167,508,121 - 167,511,530 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1167,508,598 - 167,511,530 (-)Ensembl
Rnor_6.01178,215,829 - 178,218,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,215,829 - 178,218,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01185,183,456 - 185,186,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41171,240,596 - 171,243,528 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11171,360,529 - 171,363,462 (-)NCBI
Celera1165,378,267 - 165,381,199 (-)NCBICelera
Cytogenetic Map1q33NCBI
Pth
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541428,825,651 - 28,831,117 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541428,828,389 - 28,831,417 (-)NCBIChiLan1.0ChiLan1.0
PTH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11113,347,829 - 13,351,951 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1113,347,838 - 13,351,802 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01113,653,777 - 13,657,901 (-)NCBIMhudiblu_PPA_v0panPan3
Pth
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494749,049,606 - 49,050,285 (+)NCBI
SpeTri2.0NW_0049365285,081,569 - 5,084,030 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl245,757,398 - 45,760,415 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1245,757,398 - 45,760,433 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2249,290,017 - 49,290,981 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,327,555 - 51,330,810 (+)NCBI
Vero_WHO_p1.0NW_023666038148,907,988 - 148,910,728 (+)NCBI
Pth
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247665,489,857 - 5,492,777 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 1 14 6 6 11 8 9 5
Below cutoff 3 5 5 3 3 5 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000012999   ⟹   ENSCAFP00000012029
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2136,417,062 - 36,419,967 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000088498   ⟹   ENSCAFP00000053878
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2136,417,058 - 36,418,781 (-)Ensembl
RefSeq Acc Id: NM_001003302   ⟹   NP_001003302
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12136,417,062 - 36,419,967 (-)NCBI
Dog10K_Boxer_Tasha2135,920,892 - 35,923,798 (-)NCBI
ROS_Cfam_1.02137,300,338 - 37,303,244 (-)NCBI
UMICH_Zoey_3.12136,558,731 - 36,561,637 (-)NCBI
UNSW_CanFamBas_1.02136,734,945 - 36,737,853 (-)NCBI
UU_Cfam_GSD_1.02137,024,013 - 37,026,919 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003302 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA82584 (Get FASTA)   NCBI Sequence Viewer  
  P52212 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003302   ⟸   NM_001003302
- Peptide Label: precursor
- UniProtKB: P52212 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000053878   ⟸   ENSCAFT00000088498
RefSeq Acc Id: ENSCAFP00000012029   ⟸   ENSCAFT00000012999


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008177 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000012029 ENTREZGENE
Ensembl Transcript ENSCAFT00000012999 ENTREZGENE
NCBI Gene PTH ENTREZGENE
UniProt P52212 ENTREZGENE
VGNC ID VGNC:45153 ENTREZGENE