PTH (parathyroid hormone) - Rat Genome Database

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Gene: PTH (parathyroid hormone) Canis lupus familiaris
Analyze
Symbol: PTH
Name: parathyroid hormone
RGD ID: 12368635
Description: ENCODES a protein that exhibits parathyroid hormone receptor binding (ortholog); peptide hormone receptor binding (ortholog); type 1 parathyroid hormone receptor binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); bone mineralization (ortholog); cell-cell signaling (ortholog); PARTICIPATES IN parathyroid hormone signaling pathway; ASSOCIATED WITH Albuminuria (ortholog); anemia (ortholog); Animal Disease Models (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH masitinib; Maxacalcitol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: parathyrin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12136,417,062 - 36,419,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2136,417,058 - 36,419,967 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2135,920,892 - 35,923,798 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02137,300,338 - 37,303,244 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2137,300,334 - 37,303,244 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12136,558,731 - 36,561,637 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02136,734,945 - 36,737,853 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02137,024,013 - 37,026,919 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
masitinib  (EXP)
Maxacalcitol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
bone mineralization  (IEA,ISO)
calcium ion homeostasis  (IEA)
cell-cell signaling  (IBA,ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA,ISO)
magnesium ion homeostasis  (IEA)
negative regulation of apoptotic process in bone marrow cell  (IEA,ISO)
negative regulation of bone mineralization involved in bone maturation  (ISO)
negative regulation of chondrocyte differentiation  (ISO)
negative regulation of gene expression  (IEA)
phosphate ion homeostasis  (IEA)
positive regulation of bone mineralization  (IEA,ISO)
positive regulation of cell proliferation in bone marrow  (IEA,ISO)
positive regulation of D-glucose import  (IEA,ISS)
positive regulation of gene expression  (ISO)
positive regulation of glycogen biosynthetic process  (IEA,ISS)
positive regulation of inositol phosphate biosynthetic process  (IEA)
positive regulation of ossification  (ISO)
positive regulation of osteoclast proliferation  (IEA,ISO)
positive regulation of signal transduction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
response to cadmium ion  (ISO)
response to ethanol  (ISO)
response to fibroblast growth factor  (ISO)
response to lead ion  (ISO)
response to nutrient levels  (ISO)
response to parathyroid hormone  (ISO)
response to vitamin D  (ISO)
response to xenobiotic stimulus  (ISO)
Rho protein signal transduction  (ISO)
signal transduction  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:7642102   PMID:12929937   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12136,417,062 - 36,419,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2136,417,058 - 36,419,967 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2135,920,892 - 35,923,798 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02137,300,338 - 37,303,244 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2137,300,334 - 37,303,244 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12136,558,731 - 36,561,637 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02136,734,945 - 36,737,853 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02137,024,013 - 37,026,919 (-)NCBIUU_Cfam_GSD_1.0
PTH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381113,492,054 - 13,496,181 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1113,492,054 - 13,496,181 (-)EnsemblGRCh38hg38GRCh38
GRCh371113,513,601 - 13,517,728 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361113,470,177 - 13,474,143 (-)NCBINCBI36Build 36hg18NCBI36
Build 341113,470,177 - 13,474,143NCBI
Celera1113,639,772 - 13,643,738 (-)NCBICelera
Cytogenetic Map11p15.3NCBI
HuRef1113,193,715 - 13,197,681 (-)NCBIHuRef
CHM1_11113,512,571 - 13,516,537 (-)NCBICHM1_1
T2T-CHM13v2.01113,584,795 - 13,588,918 (-)NCBIT2T-CHM13v2.0
Pth
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397112,984,783 - 112,987,879 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7112,984,787 - 112,987,777 (-)EnsemblGRCm39 Ensembl
GRCm387113,385,576 - 113,388,672 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7113,385,580 - 113,388,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv377120,529,090 - 120,532,087 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367113,176,759 - 113,179,753 (-)NCBIMGSCv36mm8
Celera7113,358,705 - 113,361,703 (-)NCBICelera
Cytogenetic Map7F1NCBI
cM Map759.19NCBI
Pth
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,942,901 - 176,946,034 (-)NCBIGRCr8
mRatBN7.21167,508,121 - 167,511,530 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1167,508,598 - 167,511,530 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1175,843,980 - 175,846,912 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,030,070 - 183,033,002 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01175,725,437 - 175,728,369 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01178,215,829 - 178,218,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,215,829 - 178,218,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01185,183,456 - 185,186,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41171,240,596 - 171,243,528 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11171,360,529 - 171,363,462 (-)NCBI
Celera1165,378,267 - 165,381,199 (-)NCBICelera
Cytogenetic Map1q33NCBI
Pth
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541428,825,651 - 28,831,117 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541428,828,389 - 28,831,417 (-)NCBIChiLan1.0ChiLan1.0
PTH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2915,932,137 - 15,936,264 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11115,894,484 - 15,898,611 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01113,653,777 - 13,657,901 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11113,347,829 - 13,351,951 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1113,347,838 - 13,351,802 (-)Ensemblpanpan1.1panPan2
Pth
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494749,049,606 - 49,050,285 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365285,083,596 - 5,084,030 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365285,081,569 - 5,084,030 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl245,757,398 - 45,760,415 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1245,757,398 - 45,760,433 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2249,290,017 - 49,290,981 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,327,555 - 51,330,810 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038148,907,988 - 148,910,728 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pth
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247665,489,800 - 5,492,871 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247665,489,857 - 5,492,777 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTH
47 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 4 5 23 19 13 3 6 3 6 28 21 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000012999   ⟹   ENSCAFP00000012029
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2136,417,062 - 36,419,967 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000088498   ⟹   ENSCAFP00000053878
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2136,417,058 - 36,418,781 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845036754   ⟹   ENSCAFP00845028776
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2137,300,334 - 37,301,146 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845036775   ⟹   ENSCAFP00845028792
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2137,300,338 - 37,303,244 (-)Ensembl
RefSeq Acc Id: NM_001003302   ⟹   NP_001003302
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12136,417,062 - 36,419,967 (-)NCBI
Dog10K_Boxer_Tasha2135,920,892 - 35,923,798 (-)NCBI
ROS_Cfam_1.02137,300,338 - 37,303,244 (-)NCBI
UMICH_Zoey_3.12136,558,731 - 36,561,637 (-)NCBI
UNSW_CanFamBas_1.02136,734,945 - 36,737,853 (-)NCBI
UU_Cfam_GSD_1.02137,024,013 - 37,026,919 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003302 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA82584 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000012029.2
  ENSCAFP00000053878.2
  ENSCAFP00030041845.1
  ENSCAFP00040031486.1
  ENSCAFP00805038357
  ENSCAFP00845028776.1
  ENSCAFP00845028792
  ENSCAFP00845028792.1
GenBank Protein P52212 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001003302   ⟸   NM_001003302
- Peptide Label: precursor
- UniProtKB: P52212 (UniProtKB/Swiss-Prot),   A0A8C0KVY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000053878   ⟸   ENSCAFT00000088498
Ensembl Acc Id: ENSCAFP00000012029   ⟸   ENSCAFT00000012999
Ensembl Acc Id: ENSCAFP00845028776   ⟸   ENSCAFT00845036754
Ensembl Acc Id: ENSCAFP00845028792   ⟸   ENSCAFT00845036775


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008177 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030025903 UniProtKB/Swiss-Prot
  ENSCAFG00040019502 UniProtKB/Swiss-Prot
  ENSCAFG00805027065 UniProtKB/Swiss-Prot
  ENSCAFG00845020842 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012999.3 UniProtKB/Swiss-Prot
  ENSCAFT00000088498.2 UniProtKB/TrEMBL
  ENSCAFT00030047835.1 UniProtKB/Swiss-Prot
  ENSCAFT00040036084.1 UniProtKB/Swiss-Prot
  ENSCAFT00805049021 UniProtKB/Swiss-Prot
  ENSCAFT00845036754.1 UniProtKB/TrEMBL
  ENSCAFT00845036775 ENTREZGENE
  ENSCAFT00845036775.1 UniProtKB/Swiss-Prot
InterPro PTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTH/PTH-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403986 UniProtKB/Swiss-Prot
NCBI Gene PTH ENTREZGENE
PANTHER PARATHYROID HORMONE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10541 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Parathyroid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF PTH UniProtKB/Swiss-Prot
PROSITE PARATHYROID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0KVY2 ENTREZGENE
  A0A8I3S4L5_CANLF UniProtKB/TrEMBL
  A0A8P0P3F5_CANLF UniProtKB/TrEMBL
  P52212 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:45153 ENTREZGENE