Pth (parathyroid hormone) - Rat Genome Database

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Gene: Pth (parathyroid hormone) Mus musculus
Analyze
Symbol: Pth
Name: parathyroid hormone
RGD ID: 11186
MGI Page MGI
Description: Enables hormone activity. Involved in calcium ion homeostasis; magnesium ion homeostasis; and phosphate ion homeostasis. Acts upstream of or within several processes, including negative regulation of apoptotic process in bone marrow cell; positive regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Located in extracellular space. Is expressed in several structures, including branchial arch; foregut gland primordium; gut gland; and thymus. Human ortholog(s) of this gene implicated in several diseases, including chronic kidney disease; diabetes mellitus (multiple); familial isolated hypoparathyroidism; hyperphosphatemia; and secondary hyperparathyroidism. Orthologous to human PTH (parathyroid hormone).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC117651; Pthp
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397112,984,783 - 112,987,879 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7112,984,787 - 112,987,777 (-)EnsemblGRCm39 Ensembl
GRCm387113,385,576 - 113,388,672 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7113,385,580 - 113,388,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv377120,529,090 - 120,532,087 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367113,176,759 - 113,179,753 (-)NCBIMGSCv36mm8
Celera7113,358,705 - 113,361,703 (-)NCBICelera
Cytogenetic Map7F1NCBI
cM Map759.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,25-Dihydroxy-16-ene-vitamin D3  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
24,25-Dihydroxyvitamin D  (ISO)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
8-Br-cAMP  (ISO)
adenine  (ISO)
alfacalcidol  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
cadmium dichloride  (ISO)
calcidiol  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium carbonate  (ISO)
calcium(0)  (ISO)
canagliflozin  (ISO)
captopril  (EXP)
CGP 52608  (ISO)
cinacalcet  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
dexamethasone  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
flavonoids  (ISO)
furosemide  (ISO)
gallium nitrate  (ISO)
hydrogen chloride  (ISO)
ketoconazole  (ISO)
lead diacetate  (ISO)
lithium atom  (ISO)
lithium carbonate  (ISO)
lithium hydride  (ISO)
Maxacalcitol  (ISO)
menaquinone  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
nickel atom  (ISO)
paricalcitol  (ISO)
phenytoin  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
protein kinase inhibitor  (ISO)
raloxifene  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (EXP,ISO)
tamoxifen  (ISO)
Terfenadine  (ISO)
theophylline  (ISO)
Trapidil  (ISO)
trichostatin A  (ISO)
uranium atom  (ISO)
vanadyl sulfate  (ISO)
vinclozolin  (ISO)
vitamin D  (ISO)
vitamin K  (EXP)
warfarin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IDA,ISO)
bone mineralization  (IMP)
calcium ion homeostasis  (IMP)
cell-cell signaling  (IBA,ISO)
homeostasis of number of cells within a tissue  (IGI)
intracellular calcium ion homeostasis  (IDA,ISO)
magnesium ion homeostasis  (IMP)
negative regulation of apoptotic process in bone marrow cell  (IGI)
negative regulation of bone mineralization involved in bone maturation  (ISO)
negative regulation of chondrocyte differentiation  (ISO)
negative regulation of gene expression  (ISO)
phosphate ion homeostasis  (IMP)
positive regulation of bone mineralization  (ISO)
positive regulation of cell proliferation in bone marrow  (IGI)
positive regulation of D-glucose import  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of inositol phosphate biosynthetic process  (ISO)
positive regulation of ossification  (ISO)
positive regulation of osteoclast proliferation  (IGI)
positive regulation of signal transduction  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
regulation of gene expression  (IDA,ISO)
response to cadmium ion  (ISO)
response to ethanol  (ISO)
response to fibroblast growth factor  (ISO)
response to lead ion  (ISO)
response to nutrient levels  (ISO)
response to parathyroid hormone  (ISO)
response to vitamin D  (ISO)
response to xenobiotic stimulus  (ISO)
Rho protein signal transduction  (ISO)
signal transduction  (IMP)
transcription by RNA polymerase II  (IDA)

Cellular Component
extracellular space  (IBA,IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutation of the signal peptide-encoding region of the preproparathyroid hormone gene in familial isolated hypoparathyroidism. Arnold A, etal., J Clin Invest. 1990 Oct;86(4):1084-7.
2. Serum vitamin D levels in children with recurrent otitis media. Cayir A, etal., Eur Arch Otorhinolaryngol. 2013 Mar 30.
3. Impact of frequent nocturnal hemodialysis on myocardial mechanics and cardiomyocyte gene expression. Chan CT, etal., Circ Cardiovasc Imaging. 2012 Jul;5(4):474-80. doi: 10.1161/CIRCIMAGING.111.971606. Epub 2012 May 30.
4. Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis. Chertow GM, etal., N Engl J Med. 2012 Dec 27;367(26):2482-94. doi: 10.1056/NEJMoa1205624. Epub 2012 Nov 3.
5. Effect of a magnesium-based phosphate binder on medial calcification in a rat model of uremia. De Schutter TM, etal., Kidney Int. 2013 Mar 13. doi: 10.1038/ki.2013.34.
6. New potent calcimimetics: II. Discovery of benzothiazole trisubstituted ureas. Deprez P, etal., Bioorg Med Chem Lett. 2013 Apr 15;23(8):2455-9. doi: 10.1016/j.bmcl.2013.01.077. Epub 2013 Feb 8.
7. Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis. Dinour D, etal., J Urol. 2013 Mar 4. pii: S0022-5347(13)03464-2. doi: 10.1016/j.juro.2013.02.3188.
8. Vitamin D Treatment and Mortality in Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Duranton F, etal., Am J Nephrol. 2013 Mar 5;37(3):239-248.
9. The effect of PTH(1-34) on fracture healing during different loading conditions. Ellegaard M, etal., J Bone Miner Res. 2013 Apr 13. doi: 10.1002/jbmr.1957.
10. Dietary phosphate binding and loading alter kidney angiotensin-converting enzyme mRNA and protein content in 5/6 nephrectomized rats. Eraranta A, etal., Am J Nephrol. 2012;35(5):401-8. doi: 10.1159/000337942. Epub 2012 Apr 19.
11. Cardiovascular diseases in older patients with osteoporotic hip fracture: prevalence, disturbances in mineral and bone metabolism, and bidirectional links. Fisher A, etal., Clin Interv Aging. 2013;8:239-56. doi: 10.2147/CIA.S38856. Epub 2013 Feb 25.
12. Parathyroid hormone gene polymorphism and secondary hyperparathyroidism in hemodialysis patients. Gohda T, etal., Am J Kidney Dis. 2002 Jun;39(6):1255-60.
13. Significance of HCG to distinguish parathyroid carcinoma from benign disease and in adding prognostic information: a hospital based study from Nepal. Gupta SP, etal., Asian Pac J Cancer Prev. 2013;14(1):325-7.
14. Sirolimus induced phosphaturia is not caused by inhibition of renal apical sodium phosphate cotransporters. Haller M, etal., PLoS One. 2012;7(7):e39229. doi: 10.1371/journal.pone.0039229. Epub 2012 Jul 30.
15. A prospective randomized pilot study on intermittent post-dialysis dosing of cinacalcet. Haq N, etal., Int Urol Nephrol. 2013 Mar 26.
16. Role of phytoestrogenic oils in alleviating osteoporosis associated with ovariectomy in rats. Hassan HA, etal., Cytotechnology. 2012 Nov 18.
17. Ferric Citrate Hydrate, a New Phosphate Binder, Prevents the Complications of Secondary Hyperparathyroidism and Vascular Calcification. Iida A, etal., Am J Nephrol. 2013 Mar 23;37(4):346-358.
18. Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity. Iida-Klein A, etal., J Biol Chem. 1997 Mar 14;272(11):6882-9.
19. Submaximal suppression of parathyroid hormone ameliorates calcitriol-induced aortic calcification and remodeling and myocardial fibrosis in uremic rats. Jung S, etal., J Hypertens. 2012 Nov;30(11):2182-91. doi: 10.1097/HJH.0b013e328357c049.
20. Vitamin D, parathyroid hormone, and cardiovascular events among older adults. Kestenbaum B, etal., J Am Coll Cardiol. 2011 Sep 27;58(14):1433-41. doi: 10.1016/j.jacc.2011.03.069.
21. Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing. Kim J, etal., Proc Natl Acad Sci U S A 1998 Oct 13;95(21):12364-9.
22. Mapping of glutathione transferase (GST) genes in the rat. Klinga-Levan K, etal., Hereditas 1993;119(3):285-96.
23. Parathyroid hormone signaling in bone and kidney. Lee M and Partridge NC, Curr Opin Nephrol Hypertens. 2009 Jul;18(4):298-302. doi: 10.1097/MNH.0b013e32832c2264.
24. Effect of lanthanum carbonate on phosphate control in continuous ambulatory peritoneal dialysis patients in Korea: a randomized prospective study. Lee YK, etal., Clin Nephrol. 2013 Feb;79(2):136-42. doi: 10.5414/CN107362.
25. Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD. London GM, etal., J Am Soc Nephrol. 2008 Sep;19(9):1827-35. doi: 10.1681/ASN.2007050622. Epub 2008 May 14.
26. The parathyroid hormone receptorsome and the potential for therapeutic intervention. Mahon MJ Curr Drug Targets. 2012 Jan;13(1):116-28.
27. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, etal., Mamm Genome 1996 Jun;7(6):413-6.
28. CHRONIC AUTOIMMUNE ATROPHIC GASTRITIS ASSOCIATED WITH PRIMARY HYPERPARATHYROIDISM: A TRANSVERSAL PROSPECTIVE STUDY. Massironi S, etal., Eur J Endocrinol. 2013 Feb 27.
29. Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats. Matsui I, etal., Am J Physiol Renal Physiol. 2013 Mar;304(6):F751-60. doi: 10.1152/ajprenal.00329.2012. Epub 2013 Jan 23.
30. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
31. MGDs mouse GO annotations MGD data from the GO Consortium
32. MGD IEA MGD IEA
33. The Bone-Protective Effect of Genistein in the Animal Model of Bilateral Ovariectomy: Roles of Phytoestrogens and PTH/PTHR1 Against Post-Menopausal Osteoporosis. Miao Q, etal., Int J Mol Sci. 2012;13(1):56-70. doi: 10.3390/ijms13010056. Epub 2011 Dec 22.
34. The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat. Moe SM, etal., J Bone Miner Res. 2011 Nov;26(11):2672-81. doi: 10.1002/jbmr.485.
35. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
36. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
37. Pro-inflammatory cytokines and bone fractures in CKD patients. An exploratory single centre study. Panuccio V, etal., BMC Nephrol. 2012 Oct 9;13:134. doi: 10.1186/1471-2369-13-134.
38. A donor splice site mutation in the parathyroid hormone gene is associated with autosomal recessive hypoparathyroidism. Parkinson DB and Thakker RV, Nat Genet. 1992 May;1(2):149-52.
39. Mouse chromosomal location of three epithelial sodium channel subunit genes and an apical sodium chloride cotransporter gene. Pathak BG, etal., Genomics 1996 Apr 1;33(1):124-7.
40. Mouse MP Annotation Import Pipeline RGD automated import pipeline
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Calcium deficiency reduces circulating levels of FGF23. Rodriguez-Ortiz ME, etal., J Am Soc Nephrol. 2012 Jul;23(7):1190-7. doi: 10.1681/ASN.2011101006. Epub 2012 May 10.
44. Occurrence of cardiovascular calcifications in normal, aging rats. Roosens B, etal., Exp Gerontol. 2012 Aug;47(8):614-9. doi: 10.1016/j.exger.2012.05.012. Epub 2012 May 24.
45. The association of parathyroid hormone with ESRD and pre-ESRD mortality in the Kidney Early Evaluation Program. Saab G, etal., J Clin Endocrinol Metab. 2012 Dec;97(12):4414-21. doi: 10.1210/jc.2012-2001. Epub 2012 Oct 12.
46. Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice. Santana AC, etal., Nephrol Dial Transplant. 2013 Jan 22.
47. Mineral metabolites and CKD progression in African Americans. Scialla JJ, etal., J Am Soc Nephrol. 2013 Jan;24(1):125-35. doi: 10.1681/ASN.2012070713. Epub 2012 Dec 14.
48. Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development. Segawa H, etal., Am J Physiol Renal Physiol. 2009 Sep;297(3):F671-8. doi: 10.1152/ajprenal.00156.2009. Epub 2009 Jul 1.
49. Phosphorus as an early marker of morbidity and mortality in type 2 chronic kidney disease diabetic patients. Silva AP, etal., J Diabetes Complications. 2013 Mar 22. pii: S1056-8727(13)00053-6. doi: 10.1016/j.jdiacomp.2013.02.007.
50. Relation of vitamin D and parathyroid hormone to cardiac biomarkers and to left ventricular mass (from the Cardiovascular Health Study). van Ballegooijen AJ, etal., Am J Cardiol. 2013 Feb 1;111(3):418-24. doi: 10.1016/j.amjcard.2012.10.021. Epub 2012 Nov 17.
51. Polymorphisms in the vitamin d receptor gene and parathyroid hormone gene in the development and progression of diabetes mellitus and its chronic complications, diabetic nephropathy and non-diabetic renal disease. Vedralova M, etal., Kidney Blood Press Res. 2012;36(1):1-9. doi: 10.1159/000339021. Epub 2012 Jun 18.
52. Osteosarcoma in Sprague-Dawley rats after long-term treatment with teriparatide (human parathyroid hormone (1-34)). Watanabe A, etal., J Toxicol Sci. 2012;37(3):617-29.
53. Two Novel Vitamin D Receptor Modulators with Similar Structures Exhibit Different Hypercalcemic Effects in 5/6 Nephrectomized Uremic Rats. Wu-Wong JR, etal., Am J Nephrol. 2013 Mar 20;37(4):310-319.
54. Mapping the time-dependent effects of paricalcitol on serum calcium, phosphorus and parathyroid hormone levels in 5/6 nephrectomized uremic rats. Wu-Wong JR, etal., Life Sci. 2013 Feb 7;92(2):161-6. doi: 10.1016/j.lfs.2012.11.018. Epub 2012 Dec 19.
55. Cyclooxygenase 2 promotes parathyroid hyperplasia in ESRD. Zhang Q, etal., J Am Soc Nephrol. 2011 Apr;22(4):664-72. Epub 2011 Feb 18.
Additional References at PubMed
PMID:1354597   PMID:1889815   PMID:1981054   PMID:2882956   PMID:3146546   PMID:6321505   PMID:7565446   PMID:8185578   PMID:8661014   PMID:8833147   PMID:8884266   PMID:8938454  
PMID:8995226   PMID:9008714   PMID:9027506   PMID:9275211   PMID:9421232   PMID:9797472   PMID:9988767   PMID:10321731   PMID:10349636   PMID:10843788   PMID:11042159   PMID:11076861  
PMID:11130978   PMID:11217851   PMID:11518254   PMID:11562466   PMID:11606467   PMID:11814673   PMID:11897779   PMID:11956184   PMID:11994406   PMID:12118100   PMID:12370121   PMID:12477932  
PMID:12488435   PMID:14517210   PMID:14610273   PMID:14634012   PMID:14701672   PMID:14969393   PMID:15037532   PMID:15476581   PMID:15601867   PMID:15601870   PMID:15843402   PMID:15910753  
PMID:16084134   PMID:16141072   PMID:16141073   PMID:16339569   PMID:16484320   PMID:16537572   PMID:17078885   PMID:17254773   PMID:17382312   PMID:17522049   PMID:17526947   PMID:17615144  
PMID:18165223   PMID:18358824   PMID:18832101   PMID:19147675   PMID:19164599   PMID:19235715   PMID:19361585   PMID:19474191   PMID:19521566   PMID:19723499   PMID:19786540   PMID:19797241  
PMID:19821778   PMID:19968565   PMID:20058231   PMID:20097749   PMID:20139972   PMID:20142103   PMID:20150282   PMID:20501677   PMID:20621835   PMID:20654714   PMID:21047792   PMID:21048959  
PMID:21203493   PMID:21267068   PMID:21345793   PMID:21542007   PMID:21677750   PMID:21829585   PMID:21862583   PMID:21873635   PMID:21896668   PMID:21908609   PMID:21966280   PMID:22040871  
PMID:22275754   PMID:22338074   PMID:22396765   PMID:22615584   PMID:22927401   PMID:23197743   PMID:23233539   PMID:23344572   PMID:23360827   PMID:23505097   PMID:23545937   PMID:23686616  
PMID:23716486   PMID:24038594   PMID:24058535   PMID:24259513   PMID:25249461   PMID:25502173   PMID:25529455   PMID:25701758   PMID:26052897   PMID:26307011   PMID:26332516   PMID:26348136  
PMID:26427650   PMID:26481310   PMID:26579618   PMID:26643174   PMID:26643857   PMID:26669699   PMID:26968768   PMID:27498418   PMID:27929669   PMID:28894263   PMID:29620150   PMID:29678580  
PMID:29913143   PMID:29993278   PMID:30677043   PMID:30973865   PMID:30979723   PMID:31936261   PMID:31987988   PMID:32169280   PMID:33575337   PMID:34101904   PMID:35071224   PMID:36321253  
PMID:37084721   PMID:37159501   PMID:38316249   PMID:38355793   PMID:38386045  


Genomics

Comparative Map Data
Pth
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397112,984,783 - 112,987,879 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7112,984,787 - 112,987,777 (-)EnsemblGRCm39 Ensembl
GRCm387113,385,576 - 113,388,672 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7113,385,580 - 113,388,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv377120,529,090 - 120,532,087 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367113,176,759 - 113,179,753 (-)NCBIMGSCv36mm8
Celera7113,358,705 - 113,361,703 (-)NCBICelera
Cytogenetic Map7F1NCBI
cM Map759.19NCBI
PTH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381113,492,054 - 13,496,181 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1113,492,054 - 13,496,181 (-)EnsemblGRCh38hg38GRCh38
GRCh371113,513,601 - 13,517,728 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361113,470,177 - 13,474,143 (-)NCBINCBI36Build 36hg18NCBI36
Build 341113,470,177 - 13,474,143NCBI
Celera1113,639,772 - 13,643,738 (-)NCBICelera
Cytogenetic Map11p15.3NCBI
HuRef1113,193,715 - 13,197,681 (-)NCBIHuRef
CHM1_11113,512,571 - 13,516,537 (-)NCBICHM1_1
T2T-CHM13v2.01113,584,795 - 13,588,918 (-)NCBIT2T-CHM13v2.0
Pth
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,942,901 - 176,946,034 (-)NCBIGRCr8
mRatBN7.21167,508,121 - 167,511,530 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1167,508,598 - 167,511,530 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1175,843,980 - 175,846,912 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,030,070 - 183,033,002 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01175,725,437 - 175,728,369 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01178,215,829 - 178,218,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,215,829 - 178,218,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01185,183,456 - 185,186,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41171,240,596 - 171,243,528 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11171,360,529 - 171,363,462 (-)NCBI
Celera1165,378,267 - 165,381,199 (-)NCBICelera
Cytogenetic Map1q33NCBI
Pth
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541428,825,651 - 28,831,117 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541428,828,389 - 28,831,417 (-)NCBIChiLan1.0ChiLan1.0
PTH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2915,932,137 - 15,936,264 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11115,894,484 - 15,898,611 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01113,653,777 - 13,657,901 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11113,347,829 - 13,351,951 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1113,347,838 - 13,351,802 (-)Ensemblpanpan1.1panPan2
PTH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12136,417,062 - 36,419,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2136,417,058 - 36,419,967 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2135,920,892 - 35,923,798 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02137,300,338 - 37,303,244 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2137,300,334 - 37,303,244 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12136,558,731 - 36,561,637 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02136,734,945 - 36,737,853 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02137,024,013 - 37,026,919 (-)NCBIUU_Cfam_GSD_1.0
Pth
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494749,049,606 - 49,050,285 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365285,083,596 - 5,084,030 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365285,081,569 - 5,084,030 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl245,757,398 - 45,760,415 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1245,757,398 - 45,760,433 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2249,290,017 - 49,290,981 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,327,555 - 51,330,810 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038148,907,988 - 148,910,728 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pth
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247665,489,800 - 5,492,871 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247665,489,857 - 5,492,777 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pth
179 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:79
Interacting mature miRNAs:83
Transcripts:ENSMUST00000079793
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787143137119485380Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80551681114551791Mouse
1301647Elpt_melevated leptin (mouse)Not determined786500186120500329Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787043932121044066Mouse
4141056Lskcn2_mLSK cell number 2 (mouse)Not determined108482996118693530Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780551681114551791Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787043932121044066Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
13524524Bodwtq6_mbody wweight QTL 6 (mouse)7107245693113055693Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787043932121044066Mouse
25394557Skmw64_mskeletal muscle weight 64, soleus (mouse)7108715780114592736Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse
35673311Ari6_mantibody response to influenza 6, day 15, IgG2b (mouse)7108699207115099235Mouse

Markers in Region
Pth  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv377120,529,295 - 120,529,753UniSTSGRCm37
Celera7113,358,910 - 113,359,368UniSTS
Cytogenetic Map7FUniSTS
cM Map752.5UniSTS
cM Map752.5UniSTS
Pth  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7FUniSTS
cM Map752.5UniSTS
Pth  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387113,385,781 - 113,386,239UniSTSGRCm38
MGSCv377120,529,295 - 120,529,753UniSTSGRCm37
Celera7113,358,910 - 113,359,368UniSTS
Cytogenetic Map7FUniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000079793   ⟹   ENSMUSP00000078723
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7112,984,787 - 112,987,777 (-)Ensembl
GRCm38.p6 Ensembl7113,385,580 - 113,388,570 (-)Ensembl
RefSeq Acc Id: NM_020623   ⟹   NP_065648
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397112,984,783 - 112,987,780 (-)NCBI
GRCm387113,385,576 - 113,388,573 (-)NCBI
MGSCv377120,529,090 - 120,532,087 (-)RGD
Celera7113,358,705 - 113,361,703 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017322045   ⟹   XP_017177534
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397112,984,783 - 112,987,879 (-)NCBI
GRCm387113,385,576 - 113,388,672 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_065648 (Get FASTA)   NCBI Sequence Viewer  
  XP_017177534 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC99656 (Get FASTA)   NCBI Sequence Viewer  
  AAH99456 (Get FASTA)   NCBI Sequence Viewer  
  BAE23743 (Get FASTA)   NCBI Sequence Viewer  
  EDL17048 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000078723
  ENSMUSP00000078723.6
RefSeq Acc Id: NP_065648   ⟸   NM_020623
- Peptide Label: precursor
- UniProtKB: Q9Z0L6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017177534   ⟸   XM_017322045
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000078723   ⟸   ENSMUST00000079793

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0L6-F1-model_v2 AlphaFold Q9Z0L6 1-115 view protein structure

Promoters
RGD ID:8665273
Promoter ID:EPDNEW_M10668
Type:multiple initiation site
Name:Pth_1
Description:Mus musculus parathyroid hormone , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387113,388,572 - 113,388,632EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97799 AgrOrtholog
Ensembl Genes ENSMUSG00000059077 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000079793 ENTREZGENE
  ENSMUST00000079793.7 UniProtKB/TrEMBL
InterPro PTH UniProtKB/TrEMBL
  PTH/PTH-rel UniProtKB/TrEMBL
KEGG Report mmu:19226 UniProtKB/TrEMBL
MGD MGI:97799 ENTREZGENE
NCBI Gene 19226 ENTREZGENE
PANTHER PARATHYROID HORMONE UniProtKB/TrEMBL
  PTHR10541 UniProtKB/TrEMBL
Pfam Parathyroid UniProtKB/TrEMBL
PhenoGen Pth PhenoGen
PIRSF PTH UniProtKB/TrEMBL
PROSITE PARATHYROID UniProtKB/TrEMBL
SMART PTH UniProtKB/TrEMBL
UniProt Q9Z0L6 ENTREZGENE, UniProtKB/TrEMBL